[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Greifswald\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":52},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,1,0,[8],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100438987","a-comparison-of-two-psychotherapy-programs-in-persistently-depressed-treatment-resistant-inpatients-100438987",false,"NCT04996433","A Comparison of Two Psychotherapy Programs in Persistently Depressed Treatment-Resistant Inpatients","Cognitive Behavioral Analysis System of Psychotherapy (CBASP) vs. Behavioral Activation (BA) in Persistently Depressed Treatment-resistant Inpatients: Efficacy, Moderators, and Mediators of Change","ChangePDD","Inclusion Criteria:\n\n* Primary DSM-5 diagnosis of PDD (300.4, 296.2x, 296.3x)\n* Total Hamilton Depression Rating Scale (HDRS-24) Score ≥ 20\n* Treatment-resistance (TR) (defined by the ATHF-SF or medication intolerance or one psychotherapy at least 25 sessions by a certified therapist in the current episode)\n* Sufficient knowledge of the German language\n* Written informed consent\n\nExclusion Criteria:\n\n* Bipolar I or II disorder\n* Active substance use disorders (abstinence shorter than 6 months)\n* Schizophrenia spectrum and other psychotic disorders\n* Antisocial personality disorder\n* Acute suicidality (HRSD item 3 \\> 2 or agreement with C-SSRS item 4 and\u002For item 5)\n* Previous CBASP or BA treatment within the last year\n* Inability to tolerate CBASP or BA (e.g., organic brain disorders, severe cognitive deficits)\n* Inability to participate in dayclinic or outpatient continuation treatment\n* Participation in another (psycho)therapeutic study of an interventional nature","ALL","18 Years","75 Years",{"count":21,"type":22},396,"ESTIMATED","INTERVENTIONAL",[25],"NA","The purpose of this study is to compare the Cognitive Behavioral Analysis System of Psychotherapy (CBASP) conducted over 16 weeks (acute and continuation treatment) with Behavioral Activation (BA; same dose and duration) in persistently depressed treatment-resistant inpatients regarding efficacy, moderators and mediators of change.",[28,29],"Persistent Depressive Disorder","Treatment-resistant Depression",[31,32,33,34,35,36,37,38],"Psychotherapy","Depression","Inpatient Treatment","Child Maltreatment","Epigenetic","Moderator","Mediator","Efficacy","RECRUITING","2026-05-20",{"date":42,"type":43},"2026-05-26","ACTUAL",{"date":45,"type":43},"2021-12-01",{"date":47,"type":22},"2028-04",{"name":49,"class":50},"University of Greifswald","OTHER",8,""]