[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Haifa\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":565},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,47,73,106,135,166,195,217,245,276,296,328,360,379,406,435,454,478,508,541],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":4},"100642302","posture-tongue-position-and-pronunciation-100642302",false,"NCT07650734","Posture, Tongue Position and Pronunciation","The Relationship Between Posture, Tongue Position and Hebrew Sibilant Consonants Pronunciation, and the Effect of Muscle Strengthening Program in Children and Teenagers","Inclusion Criteria:\n\n* People with normal hearing\n* with and without pronunciation disorders\n\nExclusion Criteria:\n\n* Children and teenagers who study in special education settings,\n* children and teenagers with phonological disorders at the prosodic or segmental level,\n* children and teenagers whose parents are under the impression that they do not hear well.",true,"ALL","6 Years","15 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Background: The main speech organ that affects the pronunciation of the various vowels is the tongue. The relationships between posture and voice, and between the position of the tongue at rest and posture, have been proven, but the relationship between pronunciation and posture has not yet been proven. The rationale for examining this relationship is that the imbalance and differing loads in poor neck and head posture cause different muscular arrangements of the muscles that support the jaw, tongue, and neck, which will thus affect pronunciation.\n\nObjectives: To examine the relationship between posture, tongue position, and the correct pronunciation in subjects with and without pronunciation disorders. In addition, to examine the effect of a muscle strengthening program on these characteristics.\n\nMethods: The study will include two parts. The first part will be a cross-sectional study using a questionnaire to examine speech therapists' perceptions of the relationship and importance of posture and pronunciation. The second part will include a prospective interventional clinical study to examine the relationship between tongue position at rest and pronunciation, posture, and muscle strength. In addition, the effect of adding muscle-strengthening training to conventional pronunciation therapy on the process of acquiring correct pronunciation will be examined.",[28],"Speech Dysfunction",[30,31,32,33,34],"pronunciation","posture","muscles","strength","tongue","NOT_YET_RECRUITING","2026-06-13",{"date":38,"type":39},"2026-06-16","ACTUAL",{"date":41,"type":22},"2026-07-01",{"date":43,"type":22},"2028-07-01",{"name":45,"class":46},"University of Haifa","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":4},"100643175","achilles-tendon-and-ankle-characterization-in-adults-with-autism-100643175","NCT07634965","Achilles Tendon and Ankle Characterization in Adults With Autism","Inclusion Criteria:\n\n* a diagnosis of ASD, or with another diagnosis that includes features of ASD (such as fragile x),\n* independent in daily activities,\n* live alone,\n* have a moderate-high level of functioning.\n* Ability to understand basic instructions for performing the tests, signing an informed consent form or having a guardian sign an informed consent form\n\nExclusion criteria:\n\n* other neurological diseases (e.g., CP, multiple sclerosis),\n* significant orthopedic injuries to the lower limb in the past year,\n* previous ankle or Achilles tendon surgeries,\n* additional diseases that may affect the structure of the Achilles tendon and ankle,\n* who have not signed an informed consent form or are not interested in participating in the study","18 Years","40 Years",{"count":21,"type":22},"OBSERVATIONAL","This study aims to identify ankle structural and functional profiles associated with sensory responsiveness and toe walking in adults with ASD. Expected outcomes include detecting group differences between adults with ASD and matched controls and identifying associations among sensory responsiveness, toe-walking status, and objective ankle measures.",[59],"Autism Disorder",[61,62,63,64],"ankle","ASD","screening","Achilles tendon","2026-06-09",{"date":67,"type":39},"2026-06-11",{"date":69,"type":22},"2026-08-10",{"date":71,"type":22},"2027-08-01",{"name":45,"class":46},{"id":74,"slug":75,"hasResults":11,"nctId":76,"briefTitle":77,"officialTitle":78,"acronym":79,"eligibilityCriteria":80,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":81,"enrollmentInfo":82,"targetDuration":4,"studyType":23,"phases":84,"briefSummary":85,"conditions":86,"keywords":88,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},"100406727","supportive-expressive-and-emotion-focused-treatment-for-depression-100406727","NCT04576182","Supportive-Expressive and Emotion-Focused Treatment for Depression","Investigating Mechanisms of Change in Supportive-Expressive vs. Emotion-Focused Treatment of Depression Using a Personalized Treatment Approach: The Case of the Theories of Weakness vs. Strength","SETEFT","Inclusion Criteria:\n\n* Meeting major depressive disorder diagnostic criteria using the structured clinical interviews for Diagnostic and Statistical Manual of Mental Disorders-5 and scoring more than 14 on the 17-item Hamilton rating scale for depression at two evaluations (one week apart) (Hamilton, 1967).\n* If on medication, patients' dosage must be stable for at least three months prior to entering the study, and they must be willing to maintain stable dosage for the duration of treatment\n* Age between 18 and 65\n* Hebrew language fluency\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Current risk of suicide or self-harm\n* current substance abuse disorders\n* current or past schizophrenia or psychosis, bipolar disorder, or severe eating disorder requiring medical monitoring\n* history of organic mental disease\n* currently in psychotherapy","65 Years",{"count":83,"type":22},124,[25],"This study will explore the mechanisms of change that are activated when individuals receive a treatment that targets their weakness and the mechanisms activated when the treatment capitalize on their strength. Patients will be assigned to one of two types of psychotherapies in treating people with a major depression disorder, expressive-supportive vs. emotion-focused treatment. Their ability to benefit from treatment based on their pre-treatment levels of insight and emotional processing will be examined. This is a four-month protocol, with a 2 year follow up period.",[87],"Major Depressive Disorder",[89,90,91,92,93,94,95],"Psychotherapy","Mechanism of change","supportive-expressive treatment","Emotion-Focused Therapy","Psychodynamic psychotherapy","Insight","emotional processing","RECRUITING","2026-05-03",{"date":99,"type":39},"2026-05-07",{"date":101,"type":39},"2020-11-29",{"date":103,"type":22},"2027-05-31",{"name":45,"class":46},1,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":121,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":105},"100618000","online-radical-acceptance-intervention-for-social-anxiety-disorder-100618000","NCT07325929","Online Radical Acceptance Intervention for Social Anxiety Disorder","Online Radical Acceptance Intervention for Social Anxiety Disorder: a Randomized Controlled Trial","RA-SAD-001","Inclusion Criteria:\n\n* Aged 18-45\n* Score \\> 9 on Mini-SPIN\n* Positive responses in brief phone screening\n* Eligibility confirmed in Zoom interview using ADIS\n* Native Hebrew speakers\n* Having regular access to a computer.\n\nExclusion Criteria:\n\n* Changes in psychiatric medication in the past 3 months\n* Current or past diagnosis of bipolar disorder\n* Current or past diagnosis of schizophrenia\n* Current or past diagnosis of PTSD\n* Current or past diagnosis of substance use disorder\n* History of traumatic brain injury (TBI)\n* Previous experience with Dialectical Behavior Therapy (DBT)\n* Currently receiving psychotherapy specifically targeting social anxiety","45 Years",{"count":116,"type":22},100,[25],"The goal of this clinical trial is to learn if a self-guided online Radical Acceptance program helps reduce symptoms of Social Anxiety Disorder. The study will also compare this program to an online relaxation skills program.\n\nThe main questions are:\n\n* Does the Radical Acceptance program lower symptoms of Social Anxiety Disorder?\n* Is the Radical Acceptance program more helpful than relaxation skills?\n\nAdults with Social Anxiety Disorder will be randomly assigned to one of two online programs. They will complete a baseline learning session and six short home practice sessions over two weeks. Participants will answer surveys about their symptoms and complete brief computer tasks. Researchers will measure changes in social anxiety at several points during the study and again a few weeks and a few months later.",[120],"Social Anxiety Disorder (SAD)",[122,123,124,125,126],"social anxiety disorder","acceptance","emotion regulation","guided self-help","digital intervention","2026-04-30",{"date":129,"type":39},"2026-05-06",{"date":131,"type":39},"2025-12-16",{"date":133,"type":22},"2027-04-01",{"name":45,"class":46},{"id":136,"slug":137,"hasResults":11,"nctId":138,"briefTitle":139,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":17,"minAge":143,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":23,"phases":146,"briefSummary":147,"conditions":148,"keywords":152,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":105},"100621217","testing-the-feasibility-of-a-self-management-support-program-for-patient-with-chronic-diseases-in-israel-100621217","NCT07367750","Testing the Feasibility of a Self-Management Support Program for Patient With Chronic Diseases in Israel","Implementation of a Self-Management Support Program Among People With Kidney Transplant and Cancer Survivors in Israel: Testing Feasibility and Effects","CDSMP-IL","Inclusion Criteria:\n\n* Age 21 years or older\n* Diagnosed with at least one chronic disease (as documented in the medical record)\n* Community-dwelling\n* Fluent in Hebrew\n\nExclusion Criteria:\n\n* Documented cognitive impairment\n* Diagnosis of major depression or other psychiatric disorder (based on self-report or medical records)\n* Hospitalization in the past 3 months","21 Years",{"count":145,"type":22},45,[25],"This study explores an intervention to support people in Israel who are living with chronic health conditions such as cancer or after kidney transplantation. It focuses on a well-known international program called the Chronic Disease Self-Management Program (CDSMP), which was developed at Stanford University. The program helps individuals build confidence and skills to better manage their health, feel more in control, and improve their day-to-day quality of life.\n\nParticipants will take part in a six-week group program, delivered online, where they will learn practical strategies for managing symptoms like fatigue or pain, setting achievable health goals, communicating effectively with healthcare professionals, and staying active and engaged. The sessions are guided by trained facilitators and include support from others facing similar health challenges.\n\nThe study will involve surveys before and after the program, as well as a follow-up six months later, to understand how the program may have helped participants. Some participants will also be invited to share their experiences in small discussion groups.\n\nBy testing this program in Israel, the researchers hope to learn how it can be adapted and offered more widely to help others living with chronic conditions.",[149,150,151],"Chronic Disease","Kidney Transplantation","Cancer Survivorship",[149,153,154,155,156,157],"Self-Management","CDSMP","Kidney","Transplantation","Cancer Survivors","2026-04-28",{"date":160,"type":39},"2026-04-29",{"date":162,"type":39},"2025-02-01",{"date":164,"type":22},"2027-03-28",{"name":45,"class":46},{"id":167,"slug":168,"hasResults":11,"nctId":169,"briefTitle":170,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":180,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":194},"100598140","pain-acceptance-training-in-patients-experiencing-emotional-distress-and-somatic-symptoms-examination-of-dialectical-thinking-as-a-mediating-factor-100598140","NCT07067619","Pain Acceptance Training in Patients Experiencing Emotional Distress and Somatic Symptoms: Examination of Dialectical Thinking as a Mediating Factor","Inclusion Criteria:\n\n1. Men and Women\n2. Aged 18-70\n3. Able to provide a signed informed consent\n4. Experiencing significant pain symptoms that interfere with daily-life functioning\n5. Experiencing significant emotional distress symptoms\n\nExclusion Criteria:\n\nPatients under the age of 18 and\u002For diagnosed with one or more of the following diagnoses will be excluded from participation in the study:\n\n1. Patients rating their average pain in the last week and in the last month as less than 3 in a 0-10 numerical rating scale (i.e. NPS)\n2. Patients rating their emotional distress levels as less than 25 in a 10-50 numerical rating scale (i.e. Kessler Psychological Distress Scale \\[K10\\])\n3. Patients diagnosed with psychotic disorders and\u002For suffering from psychotic symptoms.\n4. Patients diagnosed with Autism Spectrum disorder.\n5. Patients diagnosed with Intellectual disability.\n6. Patients diagnosed with eating disorders.\n7. Patients with Immediate suicidal risk.\n8. Patients who initiated a new drug and\u002For psychotherapy treatment within the last month.\n9. Pregnant women.\n10. Patients currently serving in the IDF.","70 Years",{"count":116,"type":22},[25],"Somatic symptoms, including physical pain, are highly prevalent among mental health patients. Current treatments have limited effectiveness for these symptoms, primarily because of patients' diminished introspective capacity and lack of emotional awareness. The current study proposes pain acceptance training as a new intervention. This intervention relies on the tenets of dialectical thinking, particularly on maintaining a dialectic perspective - at once acknowledging both the desire to end the pain and the ability to accept it as it is. We aim to examine the following: (1) the efficacy of pain acceptance training in the alleviation of somatic pain in patients with somatic symptoms; (2) the role of dialectical thinking as a mediator of pain acceptance training efficacy.",[177,178,179],"Chronic Pain","Somatic Pain","Comorbid Pain and Emotional Difficulties",[181,182,183,184,185,186],"Chronic pain","Somatic pain","Pain Acceptance","Intervention","Training","Experimental pain",{"date":188,"type":39},"2026-05-04",{"date":190,"type":39},"2024-12-01",{"date":192,"type":22},"2026-12",{"name":45,"class":46},2,{"id":196,"slug":197,"hasResults":11,"nctId":198,"briefTitle":199,"officialTitle":199,"acronym":4,"eligibilityCriteria":200,"healthyVolunteers":16,"sex":201,"minAge":202,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":23,"phases":206,"briefSummary":207,"conditions":208,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":210,"lastUpdatePostDateStruct":211,"startDateStruct":213,"completionDateStruct":214,"leadSponsor":216,"locationsCount":105},"100622144","the-musculoskeletal-system-during-puberty-in-dancers-with-scoliosis-and-the-effect-of-an-exercise-program-100622144","NCT07379801","The Musculoskeletal System During Puberty in Dancers With Scoliosis, and the Effect of an Exercise Program","Inclusion Criteria:\n\n* Female dancers aged 11-16 years who dance at least three times per week and whose parents have provided informed consent.\n* Dancers who have participated in at least three weekly hours of classical ballet during the year preceding the study and during the study year.\n* A minimum of two years of experience in classical ballet training.\n* Dancers without underlying medical conditions, not taking medications, and with no history of orthopedic surgery.\n* dancers diagnosed during the study with mild to moderate scoliosis who are not under medical follow-up requiring active orthopedic or surgical treatment.\n\nExclusion criteria:\n\n\\- Dancers who are taking medications, are not in good health, have underlying medical conditions, or have undergone any orthopedic surgery.","FEMALE","11 Years","16 Years",{"count":205,"type":22},140,[25],"assessment of the musculoskeletal system will be performed twice a year, for three years of young dancers",[209],"Development, Adolescent","2026-01-30",{"date":212,"type":39},"2026-02-03",{"date":210,"type":39},{"date":215,"type":22},"2028-08-30",{"name":45,"class":46},{"id":218,"slug":219,"hasResults":11,"nctId":220,"briefTitle":221,"officialTitle":222,"acronym":223,"eligibilityCriteria":224,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":81,"enrollmentInfo":225,"targetDuration":4,"studyType":23,"phases":227,"briefSummary":228,"conditions":229,"keywords":230,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":105},"100573677","an-individual-specific-synchrony-signature-100573677","NCT06749392","An Individual-specific Synchrony Signature","An Individual-specific Understanding of How Synchrony Becomes Curative","SynSig","Inclusion Criteria:\n\n* Current major depressive disorder based on the Diagnostic and Statistical Manual of Mental Disorders-5, and scores above 14 on the 17-item Hamilton rating scale for depression at two consecutive assessments, one week apart.\n* For participants using psychiatric medication, the dosage must be stable for at least three months before the beginning of the study, and they will be asked to maintain stable dosage during the treatment\n* Age between 18 and 65 years\n* Hebrew language proficiency\n* Provision of written informed consent.\n\nExclusion Criteria:\n\n* Current risk of suicide or self-harm\n* Current substance abuse disorders\n* Current or past schizophrenia or psychosis, bipolar disorder, or severe eating disorder requiring medical monitoring\n* History of organic mental disease\n* Currently in psychotherapy",{"count":226,"type":22},78,[25],"This study aims to establish synchrony as an individual-specific mechanism of therapeutic change and offers novel insights into the mechanisms of curative interpersonal processes. The study identifies individual-specific trait-like synchrony signature and investigates the associations between synchrony signature, the individual's trait-like characteristics, and mental health, among participants diagnosed with Major Depressive Disorder. The study further investigates how deterministic the trait-like synchrony signature is by identifying for whom, how, and when changes are anticipated. Additionally, it examines whether synchrony signature transfers to relationships with the therapist, whether and how it changes throughout treatment, and whether such potential changes are associated with improvements in mental health. Synchrony is recognized as a key driver of collaborative, affiliative, and curative relationships. While its potential role in improving mental health through interpersonal relationships has sparked growing interest, particularly in psychotherapy, the field is at a crossroads, with mixed findings challenging the widespread theoretical assumption that \"more synchrony is better.\" This study introduces a personalized framework that emphasizes individual-specific synchrony signatures, shifting from generalized assumptions to tailored understanding and interventions. The study explores how synchrony can transform relationships into curative ones by leveraging individual-tailored changes in synchrony signatures in psychotherapy. The potential impact is vast. Tailoring synchrony to individual-specific signatures represents a paradigm shift from a one-size-fits-all approach to personalized interventions. This personalized framework could revolutionize mental health care by facilitating the development of targeted strategies that enhance treatment outcomes.",[87],[231,232,233,234,235,236],"Synchrony","Therapeutic relationship","Trait-like","State-like","Multi-modal","Mechanisms of change","2025-11-21",{"date":239,"type":39},"2025-11-24",{"date":241,"type":39},"2025-11-22",{"date":243,"type":22},"2030-03-30",{"name":45,"class":46},{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":250,"acronym":4,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":254,"briefSummary":255,"conditions":256,"keywords":258,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":267,"lastUpdatePostDateStruct":268,"startDateStruct":270,"completionDateStruct":272,"leadSponsor":274,"locationsCount":275},"100603666","preventing-chronification-of-phantom-limb-pain-through-mirror-therapy-in-conjunction-with-tdcs-100603666","NCT07139483","Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With tDCS","Preventing Chronification of Phantom Limb Pain Through Mirror Therapy in Conjunction With Transcranial Direct Current Stimulation","Inclusion Criteria:\n\n* Adults (age ≥18);\n* Amputation of a single limb ≤12 weeks ago; during this period of time, 80% of amputees develop PLP. Both upper and lower limb amputees are included to increase feasibility;\n* Acute PLP stage (2 weeks since first report), with intensity ≥3 on a 0-10 VAS;\n* No change in medication in past week, excluding pro re nata analgesics;\n* Can understand the study's purpose and instructions;\n* Agrees to participate and to provide written informed consent.\n\nExclusion Criteria:\n\n* Stump wound not healed;\n* Other psychological, psychiatric, or neurological conditions;\n* Contraindications for tDCS or magnetic resonance imaging (MRI) (MRI data will not be analyzed in the proposed PhD project), including previous seizure, loss of consciousness due to head injury, metal in the head, implanted devices, claustrophobia, a skin condition or an unhealed wound on the scalp, and possibility of being pregnant;\n* Inability to provide informed consent or understand or carry out the experiment.",{"count":253,"type":22},108,[25],"Background: Most amputees experience phantom limb pain (PLP), for years after amputation. Virtually all PLP research to date has focused on the mechanisms of chronic PLP, ignoring the mechanisms of chronification. This research project will focus on combined neuromodulatory interventions of mirror therapy (MT) and trans direct-cranial stimulation (tDCS), applied for the first time at the acute state of PLP, with an aim to prevent its chronification and chronicity. In PLP, maladaptive plasticity associated with sensory deafferentation following an amputation is one of the contributors for excessive pain.\n\nMT is a well-accepted yet limited option, which is thought to counterbalance abnormal plasticity. tDCS is an emerging approach believed to affect the membrane potential and activity threshold of cortical neurons. tDCS analgesic effectiveness, however, is mild and short, rendering it a noneffective stand-alone treatment. The researchers' objectives are to investigate whether the combined therapy of MT and tDCS will prevent chronic PLP and improve its related clinical characteristics. In addition, the researchers will investigate the behavioral manifestations effects of the combined treatment. The investigators expect that the combined treatment applied at the acute stage of PLP will have synergistic effects on PLP intensity and thus avert its chronification. In addition, it will reduce phantom sensations, and negative affect, and will improve the sense of body ownership and agency and endogenous inhibition efficiency.\n\nResearch design: This randomized-controlled double-blinded study will be held at Israel's 3 largest rehabilitation centers. The study consists of 3 randomized patient arms (36 in each): (1) no-intervention, natural-course group; (2) MT + sham tDCS; (3) MT + real tDCS.\n\nMT and tDCS neuromodulatory interferences will be self-administered and consist of 20 sessions, completed during 4 weeks. The researchers outcome measures include: primary outcome: pain intensity, network-related behavioral markers, and amputation-related clinical characteristics. The data gathered will be collected at 5 timepoints.\n\nResearch novelty and innovation: The researchers proposed model will provide insights on the prevention of PLP and, potentially, other neurological pathologies involving the dysfunction of sensory systems and integration and body perception.",[257],"Phantom Limb Pain After Amputation",[259,260,261,262,263,264,265,266],"PLP","Phantom sensation","telescoping","amputation","tDCS","MT","Maladaptive plasticity","Phantom Limb Pain","2025-09-01",{"date":269,"type":39},"2025-09-08",{"date":271,"type":39},"2025-03-25",{"date":273,"type":22},"2029-03",{"name":45,"class":46},3,{"id":277,"slug":278,"hasResults":11,"nctId":279,"briefTitle":280,"officialTitle":281,"acronym":4,"eligibilityCriteria":282,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":283,"enrollmentInfo":284,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":286,"conditions":287,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":289,"lastUpdatePostDateStruct":290,"startDateStruct":292,"completionDateStruct":294,"leadSponsor":295,"locationsCount":105},"100603868","exploring-physical-therapists-and-wounded-soldiers-perceptions-toward-integrating-emotional-elements-into-rehabilitation-100603868","NCT07142109","Exploring Physical Therapists and Wounded Soldiers' Perceptions Toward Integrating Emotional Elements Into Rehabilitation","Physical Therapist and Patient Perspectives on Emotional Support in Physical Therapy Rehabilitation for Injured Soldiers: An Empirical Investigation of Needs, Facilitators, and Barriers in Providing Body-Mind Support","Inclusion Criteria:\n\n* physical therapists who currently work with, or have worked with, injured servicemen in public or private rehabilitation settings.\n* Injured servicemen between the ages of 18-35.\n\nExclusion Criteria:\n\n* Physical therapists with more than one year of professional experience.\n* Injured servicemen exclude those who suffered traumatic brain injury","35 Years",{"count":285,"type":22},120,"This study aims to examine the perceptions, attitudes, and knowledge of physical therapists regarding the integration of emotional support into the rehabilitation of wounded soldiers. It further aims to determine the patients perceptions of their own rehabilitation needs, what motivates them and what acts as barriers to their motivation. Lastly, it aims to explore the physical therapists perceptions as to what enhances or hinders patients motivation for rehabilitation success.",[288],"Rehabilitation Programs","2025-08-18",{"date":291,"type":39},"2025-08-26",{"date":293,"type":39},"2024-11-05",{"date":71,"type":22},{"name":45,"class":46},{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":16,"sex":17,"minAge":303,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":307,"conditions":308,"keywords":310,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":105},"100587768","perception-of-affordances-and-obstacle-crossing-in-people-with-parkinsons-disease-and-healthy-adults-100587768","NCT06932679","Perception of Affordances and Obstacle Crossing in People With Parkinson's Disease and Healthy Adults","Affordances and Impairments: A Paradigm for Understanding Obstacle Crossing in Parkinson's Disease","Inclusion Criteria:\n\n* Participants aged 20 to 80 years.\n* Ability to walk independently outdoors without assistive devices.\n* For Parkinson's Disease (PD) group: Diagnosis of PD confirmed by medical records.\n* For healthy control groups: No neurological or orthopedic conditions affecting gait.\n\nExclusion Criteria:\n\n* Feezing of gait (for PD group only), based on a score greater than 0 on the Freezing of Gait Questionnaire.\n* Severe visual impairment that cannot be corrected with glasses or lenses.\n* Cognitive impairment, defined as a score below 18 on the telephone-based Mini-Mental State Examination (MMSE).\n* Any orthopedic condition, pain, or other medical condition that may affect walking, based on self-report.","20 Years","80 Years",{"count":306,"type":22},180,"This study aims to explore how young adults, older adults and people with Parkinson's disease (PwP), perceive their abilty to cross obstacles while walking, and how this perception is related to their actual performance of obstacle crossing and disease-related motor and cognitive impairments. The study will explore this percepeption and the actual performance in different walking environments(floor, synthetic grass turf). Understanding how people perceive obstacles may help improve rehabilitation methods and reduce the risk of falls. The study will take place at the Motor Performance Laboratory, University of Haifa, and will include walking tasks, eye-tracking measurements, and motor and cognitive assessments.",[309],"Parkinson's Disease (PD)",[311,312,313,314,315,316,317,318,319],"Parkinson's Disease","Obstacle Crossing","Gait","Affordances","Motor Control","Balance","Fall Risk","Visual Exploration","Gaze Behavior","2025-07-17",{"date":322,"type":39},"2025-07-22",{"date":324,"type":39},"2025-04-24",{"date":326,"type":22},"2028-06-24",{"name":45,"class":46},{"id":329,"slug":330,"hasResults":11,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":16,"sex":17,"minAge":303,"maxAge":335,"enrollmentInfo":336,"targetDuration":4,"studyType":23,"phases":338,"briefSummary":340,"conditions":341,"keywords":343,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":352,"lastUpdatePostDateStruct":353,"startDateStruct":355,"completionDateStruct":357,"leadSponsor":359,"locationsCount":275},"100449540","phase-2-efficacy-of-reboxetine-and-methylphenidate-treatment-on-attentional-sensory-and-emotional-dysregulation-in-adults-with-ptsd-100449540","NCT05133804","Efficacy of Reboxetine and Methylphenidate Treatment on Attentional, Sensory and Emotional Dysregulation in Adults With PTSD","The Relation Between Attentional, Sensory and Emotional Dysregulation in Adults With Posttraumatic Stress Disorder: a Double-blind, Placebo-controlled Randomized Controlled Trial of the Combined Treatment With Reboxetine and Methylphenidate","Inclusion Criteria:\n\n* diagnosed with PTSD according to DSM-IV or DSM-5 criteria\n* current treatment at the outpatient facilities of Lev HaSharon Netanya Adult Clin\n* age between 20 and 60 years\n* PTSD diagnosis at least one month prior to study inclusion\n* no present-day re-exposure to the traumatic event\n* any psychotropic drug therapy that is being administered must be at a fixed dose for at least one month prior to the study conductance\n\nExclusion Criteria:\n\n1. comorbid major psychiatric disorder, e.g. psychotic disorder, unipolar or bipolar disorder, borderline personality disorder, or active suicidal ideation,\n2. ADHD diagnosis,\n3. significant or severe systematic disease that limits normal activity, e.g. autoimmune disease, AIDS or renal failure,\n4. cardiovascular disease, e.g. hypertension, atrioventricular (AV) block, bradycardia, or conduction disorder,\n5. severe disease that is a threat to life, e.g. acute myocardial infarction, respiratory failure, or cancer,\n6. nervous system impairment, e.g. multiple sclerosis, Alzheimer's disease, Parkinson's disease, epilepsy, or stroke,\n7. previous or current severe traumatic brain injury,\n8. glaucoma,\n9. impaired hearing,\n10. pregnancy or breastfeeding during study inclusion,\n11. active substance dependency including regular use of medical cannabis,\n12. use of steroid medication in the two months prior to study conductance,\n13. use of medication that may affect the function of the central nervous system,\n14. failure to complete all research steps","60 Years",{"count":337,"type":22},53,[339],"PHASE2","Up-to-date, no studies have examined the attentional, sensory and emotional processing (difficulties) among patients diagnosed with Posttraumatic Stress Disorder (PTSD). In addition, the efficiency of drug treatments that focus on the noradrenergic and dopaminergic, and thus influence attention processing and PTSD symptoms through these pathways, have only briefly been investigated. There is well-established and long-standing evidence for the involvement of dopamine and noradrenaline in attentional function. This previously led to an investigation by the investigator's research lab in which the investigators hypothesized the involvement of an attentional disorder would influence PTSD symptoms in a rat model. Based on these results, the current study aims to characterize attentional deficits in patients with PTSD, as well as the correlation between attention, emotional regulation and sensory processing. The investigators do this partially by conducting a case-control study and through a subsequent double-blind RCT (with only the cases). The patients will be either treated with reboxetine + methylphenidate or placebo.",[342],"Posttraumatic Stress Disorder",[342,344,345,346,347,348,349,350,351],"Attention Deficit","Sensory Processing","Emotion Regulation","Methylphenidate","Reboxetine","Randomized Controlled Trial","Electroencephalogram","Functional near-infrared spectroscopy","2025-03-26",{"date":354,"type":39},"2025-03-27",{"date":356,"type":39},"2022-06-01",{"date":358,"type":22},"2025-12-01",{"name":45,"class":46},{"id":361,"slug":362,"hasResults":11,"nctId":363,"briefTitle":364,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":366,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":368,"conditions":369,"keywords":4,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":105},"100554725","preferences-of-israeli-new-physiotherapists-in-choosing-their-future-workplace-100554725","NCT06502821","Preferences of Israeli New Physiotherapists in Choosing Their Future Workplace","Inclusion Criteria:\n\n* physiotherapists\n\nExclusion Criteria:\n\n\\-",{"count":367,"type":22},500,"This study aim to create a multidimensional body of knowledge on the factors influencing physiotherapy graduates in Israel in choosing a workplace, satisfaction with the chosen framework, and intergenerational differences in these factors. In addition, to examine the relationship between the factors for choosing a professional career in physiotherapy and choosing a workplace",[370],"Workplace","2024-12-05",{"date":373,"type":39},"2024-12-06",{"date":375,"type":39},"2024-09-15",{"date":377,"type":22},"2025-07-15",{"name":45,"class":46},{"id":380,"slug":381,"hasResults":11,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":172,"enrollmentInfo":386,"targetDuration":4,"studyType":23,"phases":387,"briefSummary":388,"conditions":389,"keywords":393,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":375,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":105},"100561629","home-within-the-heart-a-playful-journey-to-strengthen-family-resilience-100561629","NCT06592651","Home Within the Heart: a Playful Journey to Strengthen Family Resilience","Home Within the Heart","Inclusion Criteria:\n\nA parent who have been evacuated from war zones in the northern and southern regions of the country, and has a child of ages 3-6.\n\nExclusion Criteria:\n\n* A parent under the age of 18.\n* A parent who have not been evacuated from war zones.\n* A parent who has a child under 3 years of age, or above 6 years of age.",{"count":367,"type":22},[25],"The primary aim of this clinical trial is to enhance open and secure communication within the family, strengthen the parent-child bond, and reinforce feelings of safety and stability, and strengthen family resilience.\n\nIn addition,the investigators want to assess the effectiveness of a short-term therapeutic workshop in enhancing reflective functioning, beliefs about the malleability of emotions, the reported use of effective emotional regulation strategies, and the perceived parental self-efficacy and child behavior.",[390,391,392],"Family Resilience","Short-term Therapy","The Integration of Narrative Therapy and Play Therapy",[394,390,395,396,397,398],"Play therapy","Reflective function","Situational anxiety","Children's mental well-being","Parental mental well-being",{"date":400,"type":39},"2024-09-19",{"date":402,"type":39},"2024-02-02",{"date":404,"type":22},"2027-02",{"name":45,"class":46},{"id":407,"slug":408,"hasResults":11,"nctId":409,"briefTitle":410,"officialTitle":411,"acronym":4,"eligibilityCriteria":412,"healthyVolunteers":11,"sex":17,"minAge":413,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":23,"phases":417,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":96,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":429,"startDateStruct":431,"completionDateStruct":433,"leadSponsor":434,"locationsCount":105},"100557720","dyadic-creative-arts-therapies-based-intervention-for-children-with-intellectual-and-developmental-disabilities-100557720","NCT06541782","Dyadic Creative Arts Therapies-based Intervention for Children With Intellectual and Developmental Disabilities","Effectiveness of Dyadic Creative Arts Therapies (CAT)-Based Intervention for Improvement of Mother-Child Relationship in Children With Intellectual and Developmental Disabilities: A Mixed Methods RCT","Inclusion Criteria:\n\n* Children between the age of 3-7\n* Children with a prior diagnosis of IDD, or studying in special education nursery schools for children with developmental delays\n* The children's mothers\n\nExclusion Criteria:\n\n* Children with additional primary diagnosis of autism spectrum disorder or cerebral palsy\n* Children with additional diagnosis of severe physical disability or serious movement limitations\n* Children with additional diagnosis of sensory disorders such as blindness or deafness","3 Years","7 Years",{"count":416,"type":22},60,[25],"Background: Interactions between parents and children with intellectual and developmental disabilities (IDD) tend to be directive and didactic lacking in playfulness and enjoyment. Recent research has shown that parents of children with IDD who engage in more playful, creative, and enjoyable interactions tend to foster more positive relationships with their children. Early interventions have been shown to enhance parent-child interactions and promote cognitive and socio-emotional development in children with IDD.\n\nObjectives: This mixed-methods randomized controlled trial (RCT) study aims to develop a manualized dyadic Creative-Art-Therapies (CAT)-based intervention for children with IDD and their mothers and assess and explore its effects on the quality of the mother-child interaction and relationship.\n\nMethods: This mixed-methods RCT will investigate and compare two conditions: experimental dyadic CAT-based intervention for children with IDD and their mothers and control psycho-educational counseling intended for mothers only. The sample will consist of sixty dyads of children with IDD between the ages of 3-7 and their mothers, who will be randomly assigned either to experimental or control condition. The experimental group (n=30) will receive 8 weekly individual dyadic CAT-based intervention meetings at their homes and involve both the child and the mother, and the control group (n=30) will receive 8 weekly individual psycho-educational counseling meetings online via Zoom and involve the mother only.",[420],"Intellectual Disabilities Global Developmental Delay",[422,423,424,425,426,427],"Music and Play Intervention","Dyadic Intervention","Children with Intellectual and Developmental Disabilities","Playfulness","Parental Playfulness","Mother-Child Relationship","2024-08-06",{"date":430,"type":39},"2024-08-07",{"date":432,"type":39},"2024-02-22",{"date":192,"type":22},{"name":45,"class":46},{"id":436,"slug":437,"hasResults":11,"nctId":438,"briefTitle":439,"officialTitle":439,"acronym":4,"eligibilityCriteria":440,"healthyVolunteers":11,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":441,"targetDuration":4,"studyType":23,"phases":443,"briefSummary":444,"conditions":445,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":428,"lastUpdatePostDateStruct":447,"startDateStruct":449,"completionDateStruct":451,"leadSponsor":453,"locationsCount":105},"100446845","strategy-training-and-pets-to-promote-stroke-survivors-cognitive-performance-and-community-participation-100446845","NCT05098730","Strategy Training and Pets to Promote Stroke Survivor's Cognitive Performance and Community Participation","Stroke survivors with pets\n\nInclusion Criteria:\n\n1. Primary diagnosis of acute stroke\n2. At least 3 months after the stroke onset\n3. Living in a community residence with a pet\n4. Cognitive impairment as indicated by an Executive Interview score of 3 or higher\n5. Participation restrictions as indicated by an Activity Card Sort (\\\u003C80% of pre-stroke activities)\n6. Willing to participate in a 6-week program with 2 intervention sessions per week at home\n\nExclusion Criteria:\n\n1. Dementia as indicated by Montreal Cognitive Assessment score of 18 or lower\n2. Severe aphasia as indicated by the Boston Diagnostic Aphasia Examination Severity Score of 0 or 1\n3. Self-report of a central nervous system disorder other than stroke\n4. Recent drug or alcohol addiction\u002Fabuse within 3 months prior to the Mini-Neuropsychiatric Interview\n5. Severe mental illness as indicated by the PRIME-MD\n6. Prior exposure to strategy training\n7. Currently participate in rehabilitation therapy programs\n\nStroke survivors without pets\n\nInclusion Criteria:\n\n1. Primary diagnosis of acute stroke\n2. At least 3 months after the stroke onset\n3. Living in a community residence\n4. Cognitive impairment as indicated by an Executive Interview score of 3 or higher\n5. Participation restrictions as indicated by an Activity Card Sort (\\\u003C80% of pre-stroke activities)\n6. Willing to participate in a 6-week program with 2 intervention sessions per week at home\n\nExclusion Criteria:\n\n1. Dementia as indicated by Montreal Cognitive Assessment score of 18 or lower\n2. Severe aphasia as indicated by the Boston Diagnostic Aphasia Examination Severity Score of 0 or 1\n3. Self-report of a central nervous system disorder other than stroke\n4. Recent drug or alcohol addiction\u002Fabuse within 3 months prior to the Mini-Neuropsychiatric Interview\n5. Severe mental illness as indicated by the PRIME-MD\n6. Prior exposure to strategy training\n7. Currently participate in rehabilitation therapy programs",{"count":442,"type":22},50,[25],"The study will administer an intervention called strategy training to adult stroke survivors living in the community who do and do not have pets, and will examine the role of a pet in promoting cognitive performance and community participation outcomes.",[446],"Stroke",{"date":448,"type":39},"2024-08-09",{"date":450,"type":22},"2024-10-01",{"date":452,"type":22},"2026-06-30",{"name":45,"class":46},{"id":455,"slug":456,"hasResults":11,"nctId":457,"briefTitle":458,"officialTitle":459,"acronym":4,"eligibilityCriteria":460,"healthyVolunteers":11,"sex":461,"minAge":462,"maxAge":463,"enrollmentInfo":464,"targetDuration":4,"studyType":23,"phases":466,"briefSummary":467,"conditions":468,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":471,"lastUpdatePostDateStruct":472,"startDateStruct":473,"completionDateStruct":475,"leadSponsor":477,"locationsCount":4},"100557611","applying-the-pathways-and-resources-for-engagement-and-participation-protocol-among-people-with-muscles-dystrophies-100557611","NCT06540365","Applying the Pathways and Resources for Engagement and Participation Protocol Among People With Muscles Dystrophies","Feasibility and Effectiveness of the Pathways and Resources for Engagement and Participation Protocol Among Youth and Young Adults With Duchenne and Becker Muscle Dystrophies- A Pilot Study","Inclusion Criteria:\n\n* diagnosed with DBMD\n* aged 14-30 years\n* from any sector of Israeli society.\n\nExclusion Criteria:\n\n* have previously received the PREP intervention","MALE","14 Years","30 Years",{"count":465,"type":22},6,[25],"Taking part in community activities is essential for health and well-being. Yet, it is highly restricted for young people with Duchenne and Becker Muscular Dystrophies (DBMD), especially as they grow into adulthood. The Participation Pathways and Resources for Engagement and Participation (PREP) intervention is designed to help remove barriers in the environment.\n\nThis study aims to see if the PREP intervention is useful and practical for youth and young adults with DBMD. The main question is: How useful is the PREP intervention for improving participation in community-based activities chosen by the participants? Participants will start the study at different times (4, 5, or 6 weeks) and work one-on-one with an occupational therapist on a leisure activity of their choice. They will have eight sessions over 12 to 18 weeks to work on this activity.\n\nThey will use the Canadian Occupational Performance Measure (COPM) every week to track their performance and satisfaction with the chosen activity before, during, and after the intervention. The findings of this study can guide clinicians, families, and policymakers to select effective approaches that promote the participation of youth and young adults with DBMD in 'real world' activities they choose. It can also increase motivation and compliance and reduce the burden on the healthcare system, families, and people with DBMD themselves.",[469,470],"Duchenne Muscular Dystrophy","Becker Muscular Dystrophy","2024-08-05",{"date":428,"type":39},{"date":474,"type":22},"2024-08",{"date":476,"type":22},"2025-02",{"name":45,"class":46},{"id":479,"slug":480,"hasResults":11,"nctId":481,"briefTitle":482,"officialTitle":483,"acronym":4,"eligibilityCriteria":484,"healthyVolunteers":16,"sex":201,"minAge":53,"maxAge":4,"enrollmentInfo":485,"targetDuration":4,"studyType":23,"phases":487,"briefSummary":488,"conditions":489,"keywords":492,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":500,"lastUpdatePostDateStruct":501,"startDateStruct":503,"completionDateStruct":505,"leadSponsor":507,"locationsCount":105},"100552710","maternal-reflective-functioning-during-the-transition-to-motherhood-100552710","NCT06476626","Maternal Reflective Functioning During the Transition to Motherhood","Maternal Reflective Functioning During the Transition to Motherhood as a Protective Factor in the Relationship Between Personal and Environmental Characteristics and the Mental Health of Both the Mother and the Infant","Inclusion Criteria:\n\n* pregnant women in 27-30 weeks pregnant in enrollment\n* speak read and understand Hebrew\n* Has a connection to internet and ZOOM platform.\n* Ready to participate in a group workshop\n\nExclusion Criteria:\n\n* Women who can\\'t participate in a online workshop due to physical or mental health difficulties.",{"count":486,"type":22},200,[25],"The goal of this clinical trial is to learn about Maternal Reflective Function (MRF) during the transition to motherhood. The main questions it aims to answer are:\n\nDoes MRF mediates the connection between risk factors for mental health difficulties during first pregnancy and motherhood (the transition to motherhood) and outcomes related to the mother, the infant, and their relationship.\n\nParticipants will:\n\nAnswer questionnaires and clinical interviews during pregnancy and after birth of the first child (twice at third trimester, 1 and 3 months after birth).\n\nintervention group will participate in an online short intervention to enhance MRF.",[490,491],"Pregnancy","Primiparous Women",[493,494,495,496,497,498,499],"pregnancy","primiparous women","anxiety","depression","stress","mentalization","reflective function","2024-07-08",{"date":502,"type":39},"2024-07-09",{"date":504,"type":22},"2024-07-15",{"date":506,"type":22},"2027-08-30",{"name":45,"class":46},{"id":509,"slug":510,"hasResults":11,"nctId":511,"briefTitle":512,"officialTitle":513,"acronym":514,"eligibilityCriteria":515,"healthyVolunteers":16,"sex":17,"minAge":54,"maxAge":4,"enrollmentInfo":516,"targetDuration":4,"studyType":56,"phases":4,"briefSummary":518,"conditions":519,"keywords":529,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":534,"lastUpdatePostDateStruct":535,"startDateStruct":537,"completionDateStruct":538,"leadSponsor":540,"locationsCount":4},"100548075","risk-and-clinical-consequences-of-low-count-monoclonal-b-cell-lymphocytosis-lc-mbl-100548075","NCT06416267","Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)","Immune Biomarkers, Genetic Risk, and the Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)","MBL RiskConseq","Inclusion Criteria:\n\n* Individuals over the age pf 40\n\nExclusion Criteria:\n\n* Individuals with lymphoproliferative disorder",{"count":517,"type":22},1500,"The aim of this proposal is to identify immune biomarkers, genetic risk, and the clinical consequences of low count monoclonal B-cell lymphocytosis (LC MBL), a common premalignant condition affecting up to 17% of European adults age\\>40. LC MBL is a precursor to chronic lymphocytic leukemia (CLL), characterized by a circulating population of clonal B-cells. It is relatively understudied, despite emerging evidence of clinical consequences such as increased risk for life-threatening infections and lymphoid malignancies. Studies reported that male sex, age, family history of CLL, and CLL-susceptibility genetic loci were associated with LC MBL risk. These findings were reported in European ancestry individuals and have not been generalized to other thnicities. This study will provide this missing knowledge using a unique multi-ethnic Israeli population of Jews and Arabs that have one of the highest and lowest age-standardized incidence rates of CLL in the world, respectively, and characterized with different genetic backgrounds.",[520,521,522,523,524,525,526,527,528],"Monoclonal B-Cell Lymphocytosis","Chronic Lymphocytic Leukemia","Infections","Cancers","Cardiovascular Diseases","Alzheimer Disease","Dementia","Autoimmune Diseases","Parkinson Disease",[530,531,532,522,523,533],"Monoclonal B cell Lymphocytosis","Genetic Risk","Outcomes","CLL","2024-05-10",{"date":536,"type":39},"2024-05-16",{"date":474,"type":22},{"date":539,"type":22},"2040-12",{"name":45,"class":46},{"id":542,"slug":543,"hasResults":11,"nctId":544,"briefTitle":545,"officialTitle":546,"acronym":547,"eligibilityCriteria":548,"healthyVolunteers":16,"sex":17,"minAge":53,"maxAge":4,"enrollmentInfo":549,"targetDuration":19,"studyType":56,"phases":4,"briefSummary":551,"conditions":552,"keywords":555,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":558,"lastUpdatePostDateStruct":559,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":564,"locationsCount":4},"100494500","familial-b-cell-lymphoproliferative-disorders-100494500","NCT05718986","Familial B-cell Lymphoproliferative Disorders","Epidemiology of Familial B-cell Lymphoproliferative Disorders","Familial_LPD","Inclusion Criteria:\n\n* Patient inclusion criteria:\n\nPatients must have LPD and must have a family history of LPD. LPD patients who signed an informed consent to participate in the study.\n\nCriteria for the inclusion of relatives of patients:\n\nRelatives must be related by blood to LPD patients or unrelated (for control group).\n\nRelatives who signed an informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Pregnant women, special populations and those lacking judgment will not be included",{"count":550,"type":22},1000,"This study investigates families with at least two cases of B-cell lymphoproliferative disorders (LPD), and evaluates the prevalence of LPD in families, the relationship between medical history, genetic factors, and the risk of familial LPD, and various clinical outcomes for these families in a multiethnic population of Jews and Arabs in Israel.",[553,554,520,521],"Lymphoproliferative Disorders","Premalignant",[556,521,557],"lymphoproliferative disorders","Monoclonal B-cell Lymphocytosis","2024-05-07",{"date":560,"type":39},"2024-05-08",{"date":562,"type":22},"2024-06",{"date":539,"type":22},{"name":45,"class":46},""]