[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Hail\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":142},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,43,74,98,120],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100638012","bfr-training-and-knee-osteoarthritis-100638012",false,"NCT07590323","BFR Training and Knee Osteoarthritis","The Impact of Blood-flow-restricted Exercise Training and Pain Education on Pain, Function, Muscle Thickness, and Self-satisfaction in Patients With Knee Osteoarthritis.","Inclusion Criteria:\n\n* Male and female Age ≥ 40years.\n* Clinical and radiographic diagnosis of unilateral knee osteoarthritis KOA (Kellgren-Lawrence grade 2, or 3).\n* Willing to attend 3 supervised sessions\u002Fweek for 8 weeks.\n* Able to provide informed consent.\n\nExclusion Criteria:\n\n* Peripheral vascular disease, active cancer, lower limb infection, open wound\n* history of intra-articular injections within the last 3 months\n* medical condition that may affect their ability to perform exercise (uncontrolled cardiovascular, or neurological disorders)\n* cognitive and psychiatric disorders","ALL","40 Years","70 Years",{"count":20,"type":21},90,"ESTIMATED","INTERVENTIONAL",[24],"NA","Knee osteoarthritis (KOA) is a chronic, progressive degenerative joint disease characterized by cartilage and bone degeneration, synovial inflammation, and structural changes. Clinically, it presents with pain, morning stiffness, swelling, crepitus, and limited range of motion, leading to functional impairment, gait abnormalities, and reduced quality of life. Globally, KOA affects \\~302 million people. In Saudi Arabia, prevalence rises from 30.8% (ages 46-55) to \\>60% (ages 66-75), with higher rates in older, female, and obese individuals. Key risk factors include aging, female sex, obesity, prior knee injury, and genetics. The condition imposes significant health burdens and socioeconomic costs.\n\nThe International Classification of Functioning, Disability, and Health (ICF) identifies KOA as a major cause of physical disability. Pain, restricted motion, and muscle weakness drive quality-of-life decline. While pharmacological treatments exist, physical therapy interventions (education, exercise, weight loss) are crucial, though their success depends on patient behavioral change.\n\nTraditional biomedical education inadequately addresses chronic pain. Pain neuroscience education (PNE) teaches the biology and physiology of pain, supported by a biopsychosocial assessment. PNE is increasingly used by physiotherapists for chronic pain management.\n\nQuadriceps weakness contributes to functional decline in KOA. Conventional high-load resistance training may exacerbate joint pain; thus, low- to moderate-intensity training is recommended. Blood flow restriction training (BFRT) partially restricts arterial inflow and occludes venous outflow during low-load exercise, originally developed as \"kaatsu training\" in Japan. BFRT is used in rehabilitation and performance training across healthy individuals, athletes, older adults, and hypertensive patients. Factors affecting adaptations include occlusion pressure, type (continuous\u002Fintermittent), exercise intensity, and volume. Low-load resistance with BFRT reduces joint pain and increases muscle strength and mass in older adults, including those with KOA risk factors.\n\nA systematic review of six RCTs on BFRT in KOA patients showed significant pain improvement in four studies, but meta-analysis did not confirm a significant difference. Combining exercise therapy and education is recommended for musculoskeletal pain reduction; pain education alone reduced healthcare spending by 45% over three years. However, physical therapists underutilize pain management approaches, and knowledge gaps remain barriers.\n\nControlled clinical studies on BFRT in KOA are lacking. This randomized trial aims to evaluate whether BFRT, PNE, and standard treatment improve pain, function, muscle thickness, and patient satisfaction in KOA patients.",[27],"Knee Osteoarthristis",[29],"osteoarthritis; blood flow restrriction; muscles; pain; function","NOT_YET_RECRUITING","2026-05-17",{"date":33,"type":34},"2026-05-20","ACTUAL",{"date":36,"type":21},"2026-06-15",{"date":38,"type":21},"2026-12-30",{"name":40,"class":41},"University of Hail","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":49,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":4,"studyType":22,"phases":55,"briefSummary":56,"conditions":57,"keywords":59,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":42},"100627091","two-leg-rotation-and-sciatica-100627091","NCT07444125","Two-leg Rotation and Sciatica","Effect of Adding Two Leg-rotation to Standard Physical Therapy in the Treatment of Sciatica Secondary to Lumbar Discogenic Lesions.","(MWM)","Inclusion Criteria:\n\n* Both genders.\n\n  * Age between 18 and 50\n  * Have lumbar discogenic lesions.\n  * Having sciatica symptoms extending down to the knee.\n\nExclusion Criteria:\n\n* Surgical operation in the lumbar spine\n* Severe discogenic lesions with bladder or fecal incontinence or progressive muscular weakness.\n* Piriform syndrome.","18 Years","50 Years",{"count":54,"type":21},70,[24],"this study including the application of a specific technique of Mulligan mobilization calles 2 leg rotation on patients having lumbar discogenic lesion with sciatica. this technique is designed to address sciatic pain and proposed to reduce sciatica by opening the intervertebral foramnia. However, there is no systematic evedince supporting its clinical effect",[58],"Sciatica Due to Intervertebral Disc Disorder",[60,61,62,63,64],"Sciatica","lumbar disc lesion","Mulligan concept","function","physiotherapy","RECRUITING","2026-04-30",{"date":68,"type":34},"2026-05-07",{"date":70,"type":34},"2026-03-15",{"date":72,"type":21},"2026-05-30",{"name":40,"class":41},{"id":75,"slug":76,"hasResults":11,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":82,"minAge":51,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":42},"100620194","pelvic-nerve-mobilization-for-primary-dysmenorrhea-100620194","NCT07354451","Pelvic Nerve Mobilization for Primary Dysmenorrhea","Efficacy of Pelvic Nerve Mobilization in Reducing Symptoms of Primary Dysmenorrhea: A Randomized Controlled Trial","PNM-PD","Inclusion Criteria:\n\n* Female university students aged 18-30 years\n* Regular menstrual cycles (24-35 days)\n* Clinically diagnosed primary dysmenorrhea\n* Average menstrual pain intensity ≥ 5 on Visual Analog Scale\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Secondary dysmenorrhea (e.g., endometriosis, fibroids, pelvic inflammatory disease)\n* History of pelvic or spinal surgery\n* Neurological disorders\n* Current pregnancy or lactation\n* Current physiotherapy or manual therapy treatment\n* Contraindications to manual therapy","FEMALE","30 Years",{"count":85,"type":21},60,[24],"Primary dysmenorrhea is a highly prevalent condition among young women and is associated with significant pain, reduced quality of life, and academic absenteeism. Although non-steroidal anti-inflammatory drugs are commonly used, many women seek non-pharmacological alternatives due to limited effectiveness or adverse effects. Emerging evidence suggests that altered pelvic neurodynamics may contribute to dysmenorrheic pain.\n\nThis randomized controlled trial aims to evaluate the effectiveness of external pelvic nerve mobilization in reducing menstrual pain and associated symptoms among university women with primary dysmenorrhea. Participants aged 18-30 years will be randomly allocated to receive either external pelvic nerve mobilization or a sham manual therapy intervention across three consecutive menstrual cycles. Outcomes will include pain intensity, menstrual distress, quality of life, pelvic tenderness, analgesic consumption, and academic absenteeism.",[89],"Primary Dysmenorrhea (PD)","2026-04-27",{"date":92,"type":34},"2026-04-29",{"date":94,"type":34},"2025-10-20",{"date":96,"type":21},"2026-07-30",{"name":40,"class":41},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":16,"minAge":105,"maxAge":17,"enrollmentInfo":106,"targetDuration":4,"studyType":22,"phases":108,"briefSummary":109,"conditions":110,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":42},"100609492","comparative-study-on-snag-from-different-positions-low-back-pain-treatment-100609492","NCT07215286","Comparative Study on SNAG From Different Positions Low Back Pain Treatment","Comparative Study on SNAG From Loaded and Unloaded Position in the Treatment of Low Back Pain","Inclusion Criteria:\n\n* Chronic non specific low back pain for 6 weeks or more\n* Who scored between three and six on a visual analogue scale (VAS)\n* Restriction of the movement was only in flexion ROM\n\nExclusion Criteria:\n\n* Pregnancy,\n* Obese,\n* Infectious conditions of the spine,\n* Autoimmune disorders,\n* Malignancy\n* Any contraindication to physiotherapy and manual therapy\n* Any patient received physical therapy sessions last 6 months","20 Years",{"count":107,"type":21},34,[24],"Background: Low back pain (LBP) is a leading cause of disability worldwide. Mulligan's Sustained Natural Apophyseal Glides (SNAGs) are manual therapy techniques shown to reduce pain and improve function in LBP. However, whether applying SNAGs in loaded (weight-bearing) versus unloaded (non-weight-bearing) positions yields superior clinical outcomes remains unclear.\n\nObjective: To compare the effects of lumbar SNAGs applied in loaded versus unloaded positions on pain, disability, and function in individuals with chronic non-specific LBP.\n\nMethods: A randomized, single-blind, parallel-group clinical trial will recruit 34 participants with chronic LBP. Participants will be allocated to receive SNAGs in either loaded or unloaded positions, combined with a standardized exercise program, for 6 sessions over 1 week. The primary outcome is pain intensity (Numeric Pain Rating Scale) and lumbar flexion range of motion. Secondary outcomes include disability (Oswestry Disability Index). Outcomes will be measured at baseline and immediately post-treatment. Data will be analyzed using linear mixed models on an intention-to-treat basis.\n\nConclusion: This trial will determine whether a loaded SNAG application provides superior benefits compared to unloaded SNAG in the treatment of chronic LBP. Findings may guide clinical decision-making and optimize manual therapy application.",[111],"Non Specific Chronic Low Back Pain","2025-10-02",{"date":114,"type":34},"2025-10-10",{"date":116,"type":21},"2025-10-15",{"date":118,"type":21},"2026-01-15",{"name":40,"class":41},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":4,"eligibilityCriteria":126,"healthyVolunteers":11,"sex":16,"minAge":127,"maxAge":52,"enrollmentInfo":128,"targetDuration":4,"studyType":22,"phases":130,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":65,"whyStopped":4,"lastUpdateSubmitDate":134,"lastUpdatePostDateStruct":135,"startDateStruct":137,"completionDateStruct":138,"leadSponsor":140,"locationsCount":141},"100548411","controlled-active-motion-vs-early-passive-mobilization-for-flexor-tendons-repair-100548411","NCT06420648","Controlled Active Motion vs Early Passive Mobilization for Flexor Tendons Repair","A Randomized Controlled Trial Comparing Controlled Active Motion and Early Passive Mobilization Protocols for Rehabilitation of Repaired Flexor Tendons in Zone II","Inclusion Criteria:\n\n* males or females\n* between 25-50 years\n* Post-surgical repair of the flexor digitorum profundus (FDP) and superficialis (FDS) tendons of a single-digit\n* the case should be recent (2-3 days post-surgical)\n\nExclusion Criteria:\n\n* age below 25 or above 50\n* a systemic disease affecting hand joints such as rheumatic arthritis\n* thumb flexor tendon repair will be excluded\n* chronic cases\n* concurrent injuries such as phalangeal fractures, joint injuries, or significant skin loss","25 Years",{"count":129,"type":21},50,[24],"a randomized controlled trial tends to compare 2 rehabilitation approaches - early passive mobilization (EPM) and controlled active motion (CAM) - that are commonly used in the treatment of post-surgical flexor tendon repair of the hand",[133],"Flexor Tendon Rupture","2024-06-04",{"date":136,"type":34},"2024-06-06",{"date":134,"type":34},{"date":139,"type":21},"2024-12-30",{"name":40,"class":41},2,""]