[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Hartford\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":90},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,67],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":29,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100627816","the-effects-of-brief-periods-of-exercise-on-blood-pressure-100627816",false,"NCT07453550","The Effects of Brief Periods of Exercise on Blood Pressure","Inclusion Criteria:\n\n* 18-55 yrs.\n* 24 hour average BP \\>110\u002F70 mmHg, but \\\u003C 160 systolic blood pressure\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Currently taking anti-hypertensive medication smokers and alcohol drinkers Inability to undertake exercise intervention (resistance and isometric exercise)\n\nCurrent medical history of any of the following:\n\nhyperaldosteronism Diabetes mellitus (Type 1 or type 2) Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and\u002For peripheral arterial disease If female, pregnancy or currently breast feeding Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel\n\nPrevious medication history of any of the following:\n\nhyperaldosteronism Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and\u002For peripheral arterial disease thromboembolism Infection within limb within 3 months On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel",true,"ALL","18 Years","55 Years",{"count":20,"type":21},45,"ESTIMATED","INTERVENTIONAL",[24],"NA","High blood pressure is a common medical condition that affects the body's arteries. It's also called hypertension. Untreated hypertension increases the risk of heart attack, stroke and other serious health problems. Exercise is a promising tool in hypertension management. Regular participation in exercise improves vascular health, heart and lung function, and multisystem health. However, the direct evidence of the treatment effects of a brief period of exercise on blood pressure in individuals with hypertension is limited. A brief period of exercise refers to an exercise protocol that only lasts for a very short period of time, such as 5-10 minutes.",[27,28],"Hypertension (HTN)","Pre Hypertension",[30],"isometric exericse","RECRUITING","2026-04-27",{"date":34,"type":35},"2026-05-01","ACTUAL",{"date":37,"type":35},"2026-02-01",{"date":39,"type":21},"2027-06",{"name":41,"class":42},"University of Hartford","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":51,"enrollmentInfo":52,"targetDuration":4,"studyType":22,"phases":54,"briefSummary":55,"conditions":56,"keywords":4,"overallStatus":58,"whyStopped":4,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":62,"completionDateStruct":64,"leadSponsor":66,"locationsCount":4},"100627961","continuous-glucose-monitoring-in-prediabetes-100627961","NCT07455435","Continuous Glucose Monitoring in Prediabetes","Continuous Glucose Monitoring as a Tool to Promote Physical Activity in Prediabetes","Inclusion Criteria:\n\nAdults aged 18 years or older Prediabetes confirmed by the recent lab tests (within three month). If not available, it will be confirmed at lab Body mass index (BMI) \\>= 25 kg\u002Fm2 Ability to provide informed consent Ownership of a smartphone compatible with Dexcom G6 application Willing and able to comply with study procedures for 20 days\n\nExclusion Criteria:\n\nDiabetes and Glycemic Management:\n\n* Diagnosed type 1 or type 2 diabetes mellitus\n* Current use of glucose-lowering medications (metformin, sulfonylureas, GLP-1 agonists, SGLT2 inhibitors, insulin, etc.)\n* HbA1c \\>= 6.5% or fasting plasma glucose \\>= 126 mg\u002FdL\n\nCardiovascular Conditions:\n\n* History of cardiovascular disease (myocardial infarction, stroke, heart failure, coronary artery disease)\n* Peripheral artery disease\n* Uncontrolled hypertension (systolic BP \\> 160 mmHg or diastolic BP \\> 100 mmHg)\n* Raynaud phenomenon or other conditions affecting peripheral vascular assessment\n* Atrial fibrillation or other arrhythmias affecting pulse wave velocity measurement\n\nMedications Affecting Vascular Function:\n\n* Current use of vasoactive medications (nitrates, phosphodiesterase inhibitors)\n* Recent changes (\\\u003C 4 weeks) in antihypertensive medications\n* Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs)\n* Systemic corticosteroid use\n\nPhysical Activity Limitations:\n\n* Physical disability or musculoskeletal condition preventing normal ambulation\n* Use of mobility aids (wheelchair, walker, cane)\n* Medical advice to limit physical activity\n\nOther Exclusions:\n\n* Pregnancy or lactation\n* Active cancer or cancer treatment within the past 5 years (excluding non-melanoma skin cancer)\n* Chronic kidney disease (eGFR \\\u003C 60 mL\u002Fmin\u002F1.73m2)\n* Liver disease (ALT or AST \\> 3x upper limit of normal)\n* Thyroid disease (unless stable on treatment for \\> 3 months)\n* Current participation in a weight loss program or clinical trial\n* Skin conditions preventing CGM sensor placement\n* Known allergy to CGM adhesive\n* Shift work or irregular sleep schedule (may affect CGM patterns)\n* Planned travel during study period that would interfere with study visits","65 Years",{"count":53,"type":21},50,[24],"This research explores how wearable glucose monitors might help prevent type 2 diabetes in people at risk of developing the disease. Type 2 diabetes affects more than 1 in 10 Americans and costs the nation $327 billion annually. Even though it's clear that physical activity helps prevent diabetes, and that even small increases in daily movement (like walking or climbing stairs) can significantly lower risk, getting people to be more active remains challenging.\n\nA device called a continuous glucose monitor (CGM) might offer a solution. This small wearable sensor tracks blood sugar levels throughout the day and sends the information to a phone or watch. While these devices are already helping people who have diabetes manage their condition better, the investigators want to study if wearing a CGM may encourage at-risk people to become more physically active. The investigators are particularly interested in seeing whether real-time blood sugar data plus education can be an effective tool to promote lifestyle changes, such as walk more steps every day.\n\nThe study also aims to examine whether using a CGM helps stabilize blood sugar levels in prediabetes. The researchers believe that even short-term use of these monitors could lead to increased physical activity and more stable blood sugar levels, potentially helping prevent diabetes development.",[57],"Prediabetes","NOT_YET_RECRUITING","2026-03-02",{"date":61,"type":35},"2026-03-06",{"date":63,"type":21},"2026-03-21",{"date":65,"type":21},"2027-05-01",{"name":41,"class":42},{"id":68,"slug":69,"hasResults":11,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":75,"enrollmentInfo":76,"targetDuration":4,"studyType":22,"phases":78,"briefSummary":79,"conditions":80,"keywords":4,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":43},"100501717","transcutaneous-electrical-nerve-stimulation-tens-and-low-back-pain-100501717","NCT05812885","Transcutaneous Electrical Nerve Stimulation (TENS) and Low Back Pain","Transcutaneous Electrical Nerve Stimulation (TENS) and Chronic Low-Back Pain: A Randomized Crossover Trial","TENS and LBP","Inclusion Criteria:\n\n* people who have experienced back pain for at least 3 months\n* and have reported a minimal pain level of 3 on the 0-10 Pain Numerical Rating Scale (NRS)\n* age from 18-60\n* TENS naive or have not used TENS for 5 years.\n* Both men and women may participate in the study\n\nExclusion Criteria:\n\n* Serious spinal disorders, such as fractures, tumors, or inflammatory arthritis disease\n* nerve root disorders confirmed by neurological tests;\n* neurological diseases\n* severe cardiorespiratory disease\n* pregnancy\n* skin infection or lesions or change in sensation at the TENS application site\n* cancer\n* cardiac pacemaker\n* allergy to electrodes\n* use of opioids.","60 Years",{"count":77,"type":21},34,[24],"Low back pain is a significant public health problem, is very prevalent, and is often characterized by the persistence of symptoms. Unfortunately, substantial improvements in people with chronic low back pain are rare, causing most people to live with the pain. People with chronic low back pain may have an exaggerated pain response to nociceptive input into tissues that may also cause symptoms distant from the site of the primary symptoms. Historically, these symptoms were thought to be related to pathoanatomic changes to the muscles, ligaments, or joints. However, the severity of these structural changes weakly correlates with the clinical presentation and, in most cases, is not directly related to diagnostic image findings. Patients with chronic musculoskeletal pain, in general, show signs of local\u002Fcentral sensitization. The central sensitization may appear to be directly correlated with the intensity and duration of pain. Therefore, it is essential to reduce pain intensity and minimize the duration of pain to prevent this from happening.\n\nPain relief for chronic low back pain patients should be aimed at treatments that reduce central excitability and increase central inhibition. Research into chronic low back pain treatment has demonstrated strong evidence that different types of exercise decrease pain and improve quality of life. However, exercise itself may be painful, preventing a person from exercising. Thus, treatments aimed at decreasing pain will improve a person's ability to exercise and participate in activities of daily living.\n\nOne treatment aimed at reducing central excitability and increasing central inhibition is transcutaneous electrical nerve stimulation (TENS). TENS is a \"non-pharmacological\" treatment for pain that is inexpensive, safe, and easy to use. Prior studies show that TENS utilizes opioid receptors both spinally and supraspinally to inhibit nociceptive dorsal horn neurons, reduce excitatory neurotransmitter release, and reduce hyperalgesia. Thus, TENS may be particularly useful in people with chronic low back pain because it can activate descending inhibitory pathways (reduced in chronic low back pain patients) and inhibit central excitability (increased in chronic low back pain patients).\n\nPrevious studies that have investigated the effects of TENS on pain in low back pain patients have failed to use proper intensities of current, and the assessment of pain was not performed during the peak of the analgesic response. Previous studies show inadequate intensities do not reduce pain or increase pressure pain thresholds. Further, TENS typically does not affect resting pain, while changes in pressure pain thresholds and pain with movement are reduced. Thus, the current study proposes to assess the effects of TENS on measures of pain, function, and descending inhibition using the maximal tolerable intensity of TENS applied to a large area of the trunk.",[81],"Chronic Low-back Pain","2024-12-03",{"date":84,"type":35},"2024-12-04",{"date":86,"type":35},"2023-11-15",{"date":88,"type":21},"2025-07",{"name":41,"class":42},""]