[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Health Sciences Balikesir Hospital Eduation and Research\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":112},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,52,86],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100638990","effect-of-lateral-decubitus-position-after-spinal-anesthesia-on-hemodynamic-stability-in-high-risk-geriatric-patients-100638990",false,"NCT07597148","Effect of Lateral Decubitus Position After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients","The Effects of Lateral Decubitus Positioning After Spinal Anesthesia on Hemodynamic Stability in High-Risk Geriatric Patients Undergoing Lower Extremity Orthopedic Surgery: A Prospective Randomized Controlled Trial","Inclusion Criteria:\n\n* Age 65 years or older\n* ASA physical status classification III or IV\n* Scheduled for unilateral lower extremity orthopedic surgery (hip fracture, femur fracture, knee arthroplasty, tibia-fibula fracture, or similar procedures)\n* Eligible for spinal anesthesia\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (coagulopathy, recent anticoagulant or antiplatelet use without adequate washout period, local infection at injection site)\n* Severe neurological disease or pre-existing motor or sensory deficit\n* Significant spinal deformity (severe scoliosis, kyphosis) or history of previous spinal surgery\n* Known allergy to local anesthetics\n* Decompensated heart failure (ejection fraction below 30%)\n* Uncontrolled hypertension (systolic blood pressure above 180 mmHg or diastolic blood pressure above 110 mmHg)\n* Emergency surgery\n* Severe hypovolemia or active bleeding\n* Advanced dementia or inability to communicate\n* Body mass index above 40 kg\u002Fm²\n* Refusal to participate","ALL","65 Years",{"count":19,"type":20},70,"ESTIMATED","INTERVENTIONAL",[23],"NA","Spinal anesthesia is a common and preferred anesthetic technique for lower extremity orthopedic surgery in elderly patients. However, it can cause a significant drop in blood pressure (hypotension), especially in high-risk older patients with multiple medical conditions. This complication can lead to serious consequences such as heart attack, stroke, or death in vulnerable patients.\n\nThis study investigates whether keeping patients in a lateral (side-lying) position for 15 minutes after spinal anesthesia - instead of immediately turning them onto their back (supine position) - can reduce the risk of hypotension. When a patient lies on their side after receiving spinal anesthesia with a heavy (hyperbaric) local anesthetic, the medication tends to stay concentrated on the lower (operative) side, resulting in a more limited nerve block. This may help preserve blood pressure stability.\n\nWe will enroll 70 patients aged 65 years or older with high anesthetic risk (ASA physical status III or IV) scheduled for unilateral lower extremity orthopedic surgery under spinal anesthesia. Patients will be randomly assigned to two groups: one group will be kept in the lateral decubitus position (operative side down) for 15 minutes before being turned supine, and the other group will be turned supine immediately after spinal anesthesia. Blood pressure, heart rate, and oxygen saturation will be monitored continuously. The primary outcome is the incidence of hypotension during the first 15 minutes after spinal anesthesia.",[26,27,28,29],"Hypotension Drug-Induced","Spinal Aneshtesia","Geriatric","Orthopedic Surgery Patients",[31,32,33,34,35,36,37,38,39],"hypotension","spinal anesthesia","lateral decubitus position","geriatric","hyperbaric bupivacaine","unilateral spinal block","hemodynamic stability","orthopedic surgery","ASA III-IV","NOT_YET_RECRUITING","2026-05-12",{"date":43,"type":44},"2026-05-19","ACTUAL",{"date":46,"type":20},"2026-06-01",{"date":48,"type":20},"2026-08-10",{"name":50,"class":51},"University of Health Sciences Balikesir Hospital Eduation and Research","OTHER_GOV",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":59,"sex":16,"minAge":60,"maxAge":17,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100622787","neuroinflammatory-biomarkers-after-general-anesthesia-a-comparison-study-100622787","NCT07388160","Neuroinflammatory Biomarkers After General Anesthesia: A Comparison Study","Evaluation of Preoperative and Postoperative Serum BDNF, IL-1β, and HMGB1 Levels and Cognitive Changes in Patients Undergoing General Anesthesia: Differences Between Patients With No Prior General Anesthesia and Those With Multiple Anesthesia Exposures","Inclusion Criteria:\n\n* Age 18-65 years\n* Scheduled for elective cholecystectomy surgery\n* Either no previous general anesthesia exposure OR at least one or more previous general anesthesia exposures\n* Ability to provide informed consent\n* American Society of Anesthesiologists (ASA) physical status I-II\n\nExclusion Criteria:\n\n* Chronic neurological diseases (Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.)\n* Psychiatric illness requiring medication\n* Metabolic syndrome (diabetes mellitus, hypertension, cardiac disease)\n* Chronic inflammatory diseases (rheumatoid arthritis, systemic lupus erythematosus, etc.)\n* Corticosteroid or immunosuppressive therapy within the last 6 months\n* Patients requiring intensive care admission\n* Pregnancy or breastfeeding\n* Known allergy to anesthetic agents\n* Inability to provide informed consent",true,"18 Years",{"count":62,"type":20},160,"OBSERVATIONAL","This prospective, observational study investigates the impact of repeated general anesthesia exposure on neuroinflammatory biomarkers and neurotrophic factors. The study will enroll 160 adult patients (aged 18-65 years) scheduled for elective cholecystectomy surgery, divided into two groups: patients with no previous general anesthesia exposure (n=80) and patients with at least one or more previous general anesthesia exposures (n=80).\n\nSerum levels of Brain-Derived Neurotrophic Factor (BDNF), Interleukin-1 beta (IL-1β), and High Mobility Group Box 1 (HMGB1) will be measured using ELISA method at two time points: preoperatively (baseline) and 24 hours postoperatively. Cognitive function will also be assessed at both time points.\n\nThe primary objective is to evaluate whether multiple exposures to general anesthesia lead to significant differences in serum BDNF, IL-1β, and HMGB1 levels, reflecting changes in neurotrophic balance and neuroinflammatory response. This study aims to provide insights into the potential biochemical mechanisms underlying anesthesia-related cognitive changes and contribute original clinical data to the current literature on general anesthesia safety and neurobiological effects.",[66,67,68],"Anesthesia","Neuroinflammation","Cognitive Disorders",[70,71,72,67,73,74,75,76,77],"Brain Derived Neurotrophic Factor","Interleukin-1 beta","General Anesthesia","Cognitive Dysfunction","Biomarkers","Sevofluran","Inflammatory Cytokines","Anesthesia Neurotoxicity","2026-01-30",{"date":80,"type":44},"2026-02-04",{"date":82,"type":20},"2026-01-25",{"date":84,"type":20},"2026-09-25",{"name":50,"class":51},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":90,"acronym":4,"eligibilityCriteria":91,"healthyVolunteers":11,"sex":16,"minAge":60,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":96,"conditions":97,"keywords":102,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100621913","effect-of-patient-position-on-bupivacaine-dose-requirement-and-hemodynamic-stability-in-spinal-anesthesia-100621913","NCT07376798","Effect of Patient Position on Bupivacaine Dose Requirement and Hemodynamic Stability in Spinal Anesthesia","Inclusion Criteria:\n\n* Age 18-70 years\n* American Society of Anesthesiologists (ASA) physical status classification I-II\n* Scheduled for elective urogenital surgery\n* Suitable candidate for spinal anesthesia\n* Able to read, understand, and provide written informed consent\n* Body Mass Index (BMI) less than 35 kg\u002Fm²\n* Willing to participate in the study\n\nExclusion Criteria:\n\n* Contraindications to spinal anesthesia (coagulopathy, infection at injection site, patient refusal)\n* History of neurological disease\n* Spinal deformity or previous spinal surgery\n* History of allergic reaction to local anesthetics (amide-type)\n* ASA physical status classification III or higher\n* Emergency surgery\n* Pregnancy\n* Psychiatric illness preventing effective communication\n* Refusal to participate in the study\n* Unable to understand or provide informed consent","70 Years",{"count":94,"type":20},100,[23],"This study compares different combinations of local anesthetic doses and patient positions during spinal anesthesia for urogenital surgery. Spinal anesthesia is a common and safe technique where medication is injected into the lower back to numb the body during surgery.\n\nThe study will test two different doses of bupivacaine (a numbing medication): a lower dose (8 mg) and a standard dose (12 mg). It will also test two different patient positions after the spinal injection: lying flat (neutral position) and lying with the head slightly lower than the feet (Trendelenburg position).\n\nParticipants will be randomly assigned to one of four groups:\n\n* Group 1: Lower dose + lying flat\n* Group 2: Lower dose + head-down position\n* Group 3: Standard dose + lying flat\n* Group 4: Standard dose + head-down position\n\nThe study will measure how well the anesthesia works, how high the numbness spreads in the body, and how it affects blood pressure and heart rate. The goal is to find the best combination of dose and position that provides good anesthesia while keeping blood pressure stable.\n\nThis research may help doctors choose the safest and most effective anesthesia approach for each patient based on their individual needs.",[98,99,100,101],"Spinal Anesthesia","Hemodynamic Changes","Patient Positions","Bupivacaine",[98,101,103,104],"Patient Positioning","hemodynamic changes","2026-01-21",{"date":107,"type":44},"2026-01-29",{"date":78,"type":20},{"date":110,"type":20},"2026-06-30",{"name":50,"class":51},""]