[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Health Sciences Lahore\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":651},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,38,0,25,[9,50,77,101,131,159,180,204,223,248,281,311,338,359,379,401,421,447,469,498,525,547,574,605,629],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100644080","effects-of-thoracolumbar-fascia-myofascial-release-in-chronic-low-back-pain-100644080",false,"NCT07667062","Effects of Thoracolumbar Fascia Myofascial Release in Chronic Low Back Pain","Effects of Myofascial Release Targeting the Thoracolumbar Fascia on Fascial Morphology, Functional Outcomes, and Pain Self-Efficacy in Adults With Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial","TLF-MFR-LBP","Inclusion Criteria:\n\n* Adults aged 18-60 years\n* Non-specific low back pain duration \\> 12 weeks\n* Average pain intensity NRS ≥ 3 over the past week\n* Able to provide written informed consent\n* Able to attend 18 supervised sessions over 6 weeks (3 sessions\u002Fweek)\n\nExclusion Criteria:\n\n* Specific spinal pathology (fracture, disc herniation with neurological deficit, spinal stenosis, inflammatory arthropathy, malignancy)\n* Previous lumbar surgery\n* Current pregnancy\n* Severe psychiatric disorder or active psychosis\n* Manual therapy or physiotherapy for LBP within the previous 3 months\n* Systemic connective tissue disorder (e.g., Ehlers-Danlos syndrome, Marfan syndrome)\n* Contraindication to ultrasound imaging or manual therapy.","ALL","18 Years","60 Years",{"count":22,"type":23},65,"ESTIMATED","INTERVENTIONAL",[26],"NA","The thoracolumbar fascia (TLF) is thickened and stiffer in individuals with chronic non-specific low back pain (CNSLBP) and may contribute to pain persistence. Myofascial release (MFR) has been shown to reduce TLF stiffness acutely; however, its longer-term effects on fascial morphology and pain self-efficacy remain unclear. This randomized controlled trial will investigate the effects of a standardized 6-week MFR program targeting the thoracolumbar fascia compared with sham MFR in adults with CNSLBP. A total of 65 participants aged 18-60 years with CNSLBP will be randomized in a 1:1 ratio to either standardized MFR or sham MFR. The intervention will consist of 18 treatment sessions delivered over 6 weeks. Primary outcomes include thoracolumbar fascia thickness measured by B-mode ultrasound, thoracolumbar fascia stiffness measured by shear-wave elastography, and pain self-efficacy measured using the Pain Self-Efficacy Questionnaire (PSEQ). Secondary outcomes include pain intensity, functional disability, lumbar flexion range of motion, and patient global impression of change. Outcomes will be assessed at baseline and after completion of the 6-week intervention period.",[29],"Chronic Non-specific Low Back Pain",[31,32,33,34,35,36],"Thoracolumbar fascia","Myofascial release","Chronic low back pain","Fascia thickness","Fascial stiffness","Pain self-efficacy","NOT_YET_RECRUITING","2026-06-23",{"date":40,"type":41},"2026-06-26","ACTUAL",{"date":43,"type":23},"2026-06-20",{"date":45,"type":23},"2026-08",{"name":47,"class":48},"University of Health Sciences Lahore","OTHER",1,{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":57,"sex":18,"minAge":19,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100604746","effect-of-high-intensity-interval-training-on-strength-endurance-and-flexibility-100604746","NCT07153523","Effect of High Intensity Interval Training on Strength, Endurance and Flexibility","Effect of High Intensity Interval Training Versus Conservative Treatment on Strength, Endurance and Flexibility of Undergraduate Physical Therapy Students","Inclusion Criteria:\n\n* Undergraduate physical therapy students aged 18-24 years.\n* Both genders male and female\n* DPT students from 1st to final year\n\nExclusion Criteria:\n\n* Students with musculoskeletal pain and injuries.\n* Any neurological and cardiovascular restrictions.\n* Any trauma like fracture.\n* Surgical limitation of range of motion.\n* Any systemic disease.\n* Malignant or benign Tumor.\n* Students who are athletes or doing regular exercise",true,"24 Years",{"count":60,"type":23},66,[26],"Strength and endurance are essential components for physical fitness of any individual. High intensity interval training provides time efficient benefits for strength and endurance training. Physical Therapy professionals and students need physical fitness for effective clinical performance of patients. There is limited research regarding physical performance of physical therapists itself",[64],"High Intensity Interval Training",[66],"high intensity interval training","RECRUITING","2026-06-14",{"date":70,"type":41},"2026-06-16",{"date":72,"type":41},"2026-03-02",{"date":74,"type":23},"2026-06-15",{"name":47,"class":48},2,{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":84,"targetDuration":4,"studyType":24,"phases":86,"briefSummary":87,"conditions":88,"keywords":90,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":49},"100618119","effect-of-oral-ice-chips-to-prevent-chemotherapy-induced-oral-mucositis-in-patient-with-solid-tumor-treated-with-5-fluorouracil-and-methotrexate-100618119","NCT07327476","Effect of Oral Ice Chips to Prevent Chemotherapy-Induced Oral Mucositis in Patient With Solid Tumor Treated With 5 Fluorouracil and Methotrexate","Effects Of Oral Ice Chips On Prevention of Chemotherapy Induced Oral Mucositis In Patients With Solid Tumors Treated With 5 Fluorouracil and Methotrexate In Tertiary Care Hospital , Lahore: A Randomize Control Trial","Inclusion Criteria\n\n* Adults aged 18-60 years.\n* Patients treated with 5-Fluorouracil and Methotrexate regimens.\n* Patients scheduled for a two-week cycle of chemotherapy.\n* Patients able to tolerate ice and able to communicate effectively.\n\nExclusion Criteria\n\n* Patients with diabetes mellitus, cardiovascular disorders, or any immune- compromised disease.\n* Patients with head and neck surgeries, oral or pharyngeal cancer, or any problems in the oral cavity.\n* Patients currently enrolled in or who have signed consent for any other clinical studies that could interfere with the desired outcomes.",{"count":85,"type":23},102,[26],"The goal of this randomized controlled clinical trial is to determine whether oral cryotherapy using ice chips can prevent and reduce the incidence and severity of chemotherapy-induced oral mucositis in adult cancer patients receiving 5-fluorouracil and methotrexate chemotherapy regimens.\n\nThe main questions it aims to answer are:\n\nDoes the application of oral ice chips reduce the severity of oral mucositis compared to routine mouth care alone?\n\nIs there a significant difference in oral mucositis grades between patients receiving oral cryotherapy and those receiving standard mouthwash care?\n\nResearchers will compare the experimental group receiving oral ice chips during chemotherapy plus routine mouthwash care with the control group receiving routine mouthwash care only to evaluate the effectiveness of oral cryotherapy in reducing oral mucositis severity.\n\nParticipants will:\n\nBe randomly assigned to either the experimental group (n = 51) or control group (n = 51)\n\nReceive chemotherapy with 5-fluorouracil or methotrexate\n\nUse routine mouthwash (normal saline\u002Fsodium bicarbonate\u002Fchlorhexidine) at home\n\nReceive oral ice chips during chemotherapy infusion (experimental group only)\n\nBe assessed for oral mucositis severity using the WHO Oral Mucositis Grading Scale before and after the intervention",[89],"Chemotherapy Induced Oral Mucositis",[91,92,93],"Cryotherapy","Solid tumor","oral mucositis","2026-06-13",{"date":70,"type":41},{"date":97,"type":23},"2026-07-15",{"date":99,"type":23},"2026-11-30",{"name":47,"class":48},{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":24,"phases":111,"briefSummary":112,"conditions":113,"keywords":117,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":123,"lastUpdatePostDateStruct":124,"startDateStruct":126,"completionDateStruct":128,"leadSponsor":130,"locationsCount":49},"100639316","r-officinalis-as-pulpotomy-agent-in-permanent-teeth-with-irreversible-pulpitis-100639316","NCT07610057","R. Officinalis as Pulpotomy Agent in Permanent Teeth With Irreversible Pulpitis","Comparative Clinical and Radiographic Evaluation of Rosmarinus Officinalis Versus Mineral Trioxide Aggregate as Pulpotomy Medicament in Vital Mature Permanent Teeth With Irreversible Pulpitis","Inclusion Criteria\n\n* Healthy patients (ASA classification 1 and 2) of age range of 18-40 of both sexes would be included.\n* Vital mature permanent posterior teeth with deep caries approaching the pulp as seen on periapical x-ray.\n* Pain indicative of irreversible pulpitis (spontaneous pain or pain exacerbated by a cold stimulus which could last from a few seconds to hours), which a cold test could reproduce.\n* Tooth will be selected on the basis of working diagnosis i.e. successful hemostasis within 5 minutes after removal of coronal pulp.\n* Absence of clinical signs or symptoms suggesting a non-vital tooth such as tenderness to percussion or palpation, mobility, presence of abscess, soft tissue swelling or suppurating sinus.\n* Absence of radiographic changes as; furcation or periapical pathology, internal or external root resorption or calcification in the canals.\n* The tooth structure of selected teeth should be restorable after completion of the treatment\n\nExclusion Criteria:\n\n* Patients with ASA classification 3, 4 ,5 and 6 would be\n* Patients taking antibiotics within last 2 weeks.\n* Teeth with pulp necrosis, cracked tooth, internal or external resorption, calcified canals, acute or chronic apical periodontitis with an associated sinus tract or periapical radiolucency.\n* Periodontally compromised tooth.\n* Uncooperative patients or failure to obtain authorization from patients.","40 Years",{"count":110,"type":23},100,[26],"This study evaluates and compares the clinical and radiographic outcomes of Rosmarinus officinalis and Mineral Trioxide Aggregate (MTA) when used as pulpotomy medicaments in vital mature permanent teeth with irreversible pulpitis. The aim is to determine the effectiveness of both materials in terms of pain reduction and periapical healing. While MTA is considered a gold standard, it has limitations such as high cost, long setting time, and potential discoloration. Therefore, this study investigates Rosmarinus officinalis as a natural, cost-effective alternative with comparable therapeutic potential. This study also provide an alternative to RCT in teeth with irreversible pulpitis",[114,115,116],"Irreversible Pulpitis","Pulpotomy","MTA Vital Tooth Pulpotomy",[118,119,120,121,122],"pulpotomy","rosemarinus officinalis","MTA","permanent teeth with irreversible pulpitis","Vital pulp theray","2026-05-21",{"date":125,"type":41},"2026-05-27",{"date":127,"type":23},"2026-06-01",{"date":129,"type":23},"2026-12-31",{"name":47,"class":48},{"id":132,"slug":133,"hasResults":12,"nctId":134,"briefTitle":135,"officialTitle":136,"acronym":137,"eligibilityCriteria":138,"healthyVolunteers":12,"sex":18,"minAge":139,"maxAge":140,"enrollmentInfo":141,"targetDuration":4,"studyType":24,"phases":143,"briefSummary":144,"conditions":145,"keywords":147,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":151,"lastUpdatePostDateStruct":152,"startDateStruct":154,"completionDateStruct":156,"leadSponsor":158,"locationsCount":49},"100629520","exergaming-for-improving-upper-limb-functions-in-parkinsons-disease-100629520","NCT07475741","Exergaming for Improving Upper Limb Functions in Parkinson's Disease","Exergaming With Physical Objects for Upper Limb Rehabilitation in Parkinson's Disease: Effects on Functional Outcome","Exergaming","Inclusion Criteria:\n\n* Early-stage Parkinson's Disease from I-III of Hoehn and Yahr scale\n* Cognitinve Assessment MMSE \\>= 24 Score\n* Able to communicate and understand the commands\n* Must be on regular use of Levodopa\u002Fcarbidopa\n\nExclusion Criteria:\n\n* Advanced stage IV or V\n* Patients with severe cognitive deficits.\n* History of suffering from other neurological or musculoskeletal conditions affecting hand use for the exercise\n* Not taking any medicine for systemic illness","45 Years","85 Years",{"count":142,"type":23},30,[26],"Parkinson's Disease commonly results in impaired hand dexterity, reducing a patient's ability to perform activities of daily living. While digital exergaming has been used to encourage physical activity and improve motor function, it often lacks real-world tactile engagement. Integrating physical objects into exergaming known as a phygital approach which may enhance sensorimotor learning and functional carryover. However, its impact on upper limb functional outcomes in PD remains underexplored.\n\nObjectives: To assess the effectiveness of exergaming with physical objects on functional outcomes of upper limb rehabilitation in individuals with Parkinson's Disease.\n\nMethodology: This randomized controlled pilot study will include 30 individuals with early-stage Parkinson's Disease, recruited through convenience sampling and randomly assigned to either a phygital exergaming group or a control group. Both groups will receive sessions over three monthd (3 sessions\u002Fweek, 30 minutes each). The phygital group will perform task-based exergaming using both physical objects and digital prompts, while the control group will use digital prompts alone. Functional outcomes will be assessed using the Box and Block Test (BBT), at baseline (day 1) and post intervention 12 weeks.\n\nStatistical Analysis: Data will be analyzed using SPSS version 25. Descriptive statistics like gender, stages of diseases etc. will be summarized and described as bar charts and percentages. Within-group differences will be assessed using paired t-tests or Wilcoxon signed-rank tests based on data normality. Between-group comparisons will be conducted using independent t-tests or Mann-Whitney U tests. A p-value of less than 0.05 will be considered statistically significant.",[146],"Parkinsons Disease (PD)",[137,148,149,150],"Parkinson Disease","Physical Therapy","Upper Limb Rehabilitation","2026-05-14",{"date":153,"type":41},"2026-05-19",{"date":155,"type":41},"2026-02-20",{"date":157,"type":23},"2026-11",{"name":47,"class":48},{"id":160,"slug":161,"hasResults":12,"nctId":162,"briefTitle":163,"officialTitle":164,"acronym":4,"eligibilityCriteria":165,"healthyVolunteers":12,"sex":18,"minAge":166,"maxAge":4,"enrollmentInfo":167,"targetDuration":4,"studyType":24,"phases":169,"briefSummary":170,"conditions":171,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":177,"leadSponsor":179,"locationsCount":4},"100640291","levofloxacin-based-sequential-therapy-versus-bismuth-quadruple-therapy-for-helicobacter-pylori-eradication-100640291","NCT07574983","Levofloxacin-Based Sequential Therapy Versus Bismuth Quadruple Therapy for Helicobacter Pylori Eradication","Levofloxacin-Based Sequential Therapy Compared With Bismuth-Based Quadruple Therapy for Eradication of Helicobacter Pylori Infection: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 20 years and older\n* Confirmed Helicobacter pylori infection by stool antigen testing\n* Willingness to comply with the assigned treatment regimen\n* Ability to provide informed consent\n* Willingness to complete follow-up evaluation\n\nExclusion Criteria:\n\n* Use of antibiotics within 4 weeks prior to enrollment\n* Active gastrointestinal infection other than Helicobacter pylori\n* Previous gastrointestinal tract surgery\n* Pregnant or lactating females\n* Known allergy or intolerance to study medications\n* Psychiatric illness or other condition impairing treatment compliance\n* Severe comorbid illness making participation unsuitable in the investigator's judgment","20 Years",{"count":168,"type":23},90,[26],"This randomized controlled trial aims to compare the efficacy and safety of levofloxacin-based sequential therapy versus bismuth-based quadruple therapy for eradication of Helicobacter pylori infection in adult patients. Helicobacter pylori infection remains highly prevalent in developing countries and is associated with gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma, and gastric cancer. Increasing antibiotic resistance has reduced the effectiveness of conventional treatment regimens, creating a need for alternative first-line therapies with improved eradication rates and acceptable tolerability.\n\nEligible adult patients diagnosed with H. pylori infection by stool antigen testing will be recruited from the Gastroenterology Department of Services Hospital Lahore. Participants will be randomly assigned in a 1:1 ratio to receive either levofloxacin-based sequential therapy or bismuth-based quadruple therapy for 14 days.\n\nThe primary outcome of the study is successful eradication of H. pylori infection, confirmed by stool antigen testing performed 6 weeks after completion of therapy. Secondary outcomes include treatment-related adverse effects, treatment compliance, and overall treatment cost.\n\nThe study aims to identify an effective and affordable treatment strategy for H. pylori eradication in a population with high antibiotic resistance and socioeconomic limitations.",[172],"HELICOBACTER PYLORI INFECTIONS","2026-05-02",{"date":175,"type":41},"2026-05-08",{"date":127,"type":23},{"date":178,"type":23},"2026-12-30",{"name":47,"class":48},{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":12,"sex":18,"minAge":166,"maxAge":20,"enrollmentInfo":187,"targetDuration":4,"studyType":24,"phases":189,"briefSummary":190,"conditions":191,"keywords":193,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":201,"leadSponsor":203,"locationsCount":4},"100617639","effect-of-hands-and-feet-exercises-on-taxane-based-chemotherapy-induced-peripheral-neuropathy-in-patients-with-solid-tumors-100617639","NCT07321236","Effect of Hands and Feet Exercises on Taxane Based Chemotherapy Induced Peripheral Neuropathy in Patients With Solid Tumors","Effect of Hands and Feet Exercises on Severity of Taxane-Based Chemotherapy-Induced Peripheral Neuropathy in Patients With Solid Tumors: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Cancer patients receiving taxane-based chemotherapy on alternate week.\n* Age 20-60 years, both male and female.\n* Patients having Grade I neuropathy by NCI-CTCEA criteria.\n\nExclusion criteria:\n\n* Patients with peripheral neuropathy not caused by chemotherapy.\n\n  * Patient with type-1 and type- 2 diabetes.\n* Patients with neuropsychiatric disorders.\n* Patients having any skin ulcer.\n* Individuals having hand foot fracture and varicose veins.\n* Individuals with paraplegia.\n* Patients receiving radiotherapy.",{"count":188,"type":23},58,[26],"The goal of this clinical trial is to determine whether hand and foot exercises can reduce the severity of Taxane-based chemotherapy-induced peripheral neuropathy (CIPN) in adult cancer patients aged 20-60 years who have Grade 1I neuropathy as defined by the NCI-CTCAE criteria.\n\nThe main questions it aims to answer are:\n\n* Do hand and foot exercises reduce the severity of sensory and motor neuropathic symptoms in patients receiving Taxane based chemotherapy?\n* Is the severity of peripheral neuropathy lower in the exercise group compared to patients receiving standard care alone? Researchers will compare patients receiving standard care (control group) with those receiving standard care plus a structured hand and foot exercise program (experimental group) to see if the exercises lead to greater improvement in neuropathy severity scores.\n\nParticipants will:\n\n* Receive baseline assessment using the EORTC QLQ-CIPN20 questionnaire.\n* In the experimental group, learn and perform a 15-minute hand and foot exercise routine on chemotherapy day and continue it at home using a provided brochure.\n* Participate in telephonic follow-ups to support compliance and monitor symptoms.\n* Undergo a follow-up assessment at alternate week to measure changes in neuropathy severity.",[192],"Peripheral Neuropathy",[194,195,196],"Peripheral neuropathy","Taxane","Chemotherapy","2026-04-29",{"date":199,"type":41},"2026-05-06",{"date":127,"type":23},{"date":202,"type":23},"2026-09-01",{"name":47,"class":48},{"id":205,"slug":206,"hasResults":12,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":4,"eligibilityCriteria":210,"healthyVolunteers":12,"sex":211,"minAge":19,"maxAge":4,"enrollmentInfo":212,"targetDuration":4,"studyType":24,"phases":214,"briefSummary":215,"conditions":216,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":218,"startDateStruct":220,"completionDateStruct":221,"leadSponsor":222,"locationsCount":4},"100617728","effect-of-foot-reflexology-on-chemotherapy-induced-nausea-and-vomiting-in-breast-cancer-patients-100617728","NCT07322393","Effect of Foot Reflexology On Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients","Effect of Foot Reflexology On Chemotherapy Induced Nausea and Vomiting in Breast Cancer Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\nBreast Cancer patients aged \\>18 Patients receiving chemotherapy in curative setting\n\nExclusion Criteria:\n\nPatients with paraplegia. Patients with skin ulcers or wounds. Patients with psychiatric conditions. Patients with foot fractures and varicose veins. Patients with GIT and Liver Cancer","FEMALE",{"count":213,"type":23},50,[26],"This study aims to evaluate the effect of foot reflexology on chemotherapy-induced nausea and vomiting in breast cancer patients. Nausea and vomiting are common side effects of chemotherapy and can negatively affect patients' comfort and quality of life. Foot reflexology is a non-invasive complementary therapy that involves applying pressure to specific points on the feet. The study will compare patients who receive foot reflexology along with standard care to those who receive standard care alone, to determine whether foot reflexology helps reduce the severity of nausea and vomiting during chemotherapy.",[217],"Chemotherapy-induced Nausea and Vomiting",{"date":219,"type":41},"2026-04-30",{"date":127,"type":23},{"date":202,"type":23},{"name":47,"class":48},{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":18,"minAge":108,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":24,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":241,"lastUpdatePostDateStruct":242,"startDateStruct":244,"completionDateStruct":245,"leadSponsor":247,"locationsCount":49},"100630169","effectiveness-of-nurse-led-interventions-on-respiratory-outcomes-in-hospitalized-patients-with-acute-exacerbation-of-chronic-obstructive-pulmonary-disease-100630169","NCT07484178","Effectiveness of Nurse-Led Interventions on Respiratory Outcomes in Hospitalized Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease","Effectiveness of Nurse-Led Interventions on Respiratory Outcomes in Hospitalized Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Randomized Control Trial","Inclusion Criteria:\n\n* Diagnosed cases of COPD admitted for acute exacerbation according to Global Initiative for Chronic Obstructive Lung Disease.\n* Adults aged \\> 40 years (WHO, 2023; GOLD, 2024).\n* Both genders (male \\& female).\n* Hemodynamically stable at the time of enrollment in terms of vital signs (e.g., blood pressure \\> 90\u002F60 mmHg, heart rate between 60-100 bpm) to safely undergo nursing interventions without acute risk (Jarhyan et al., 2021).\n* Dyspnea Grade ≥ 2 on the mMRC Scale (Mahler and Wells, 1988).\n* Blood Oxygen Saturation (SpO₂) ≥ 88% on Room Air or Oxygen Therapy (O'Driscoll, 2017).\n\nExclusion Criteria:\n\n* Dyspnea due to cardio-pulmonary disease or other co-morbidities.\n* Patients on mechanical ventilation and ICU admission.\n* Patients with mental disorders.\n* Patients with upper airway obstruction.",{"count":231,"type":23},68,[26],"The goal of this clinical trial is to evaluate whether respiratory nursing interventions can improve respiratory outcomes in patients hospitalized with acute exacerbation of Chronic Obstructive Pulmonary Disease (COPD). The main questions it aims to answer are:\n\nDo respiratory nursing interventions improve dyspnea levels measured by the Modified Medical Research Council (mMRC) Dyspnea Scale? Do these interventions improve oxygen saturation and pulmonary function (FVC, FEV1, and FEV1\u002FFVC ratio)?\n\nResearchers will compare patients receiving respiratory nursing interventions plus routine hospital care with patients receiving routine hospital care alone to determine whether the interventions improve respiratory outcomes.\n\nParticipants will:\n\nUndergo baseline assessment using the mMRC Dyspnea Scale, pulse oximetry, and pulmonary function tests.\n\nReceive either respiratory nursing interventions (deep breathing exercises, chest percussion, postural drainage, and lukewarm water intake) along with routine care or routine hospital care alone.\n\nBe reassessed after the intervention period using the same respiratory outcome measures.",[235],"Acute Exacerbation Copd",[237,238,239,240],"Nursing Intervention","COPD","Acute Exacerbation","Respiratory outcomes","2026-04-10",{"date":243,"type":41},"2026-04-15",{"date":173,"type":23},{"date":246,"type":23},"2026-10-20",{"name":47,"class":48},{"id":249,"slug":250,"hasResults":12,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":4,"eligibilityCriteria":254,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":255,"enrollmentInfo":256,"targetDuration":4,"studyType":24,"phases":257,"briefSummary":258,"conditions":259,"keywords":266,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":49},"100628855","effectiveness-of-pilates-on-postural-correction-core-strength-and-flexibility-in-younger-individuals-with-non-specific-low-backache-100628855","NCT07467070","Effectiveness of Pilates on Postural Correction, Core Strength and Flexibility in Younger Individuals With Non-specific Low Backache","Effects of Pilates on Postural Correction, Core Strength and Flexibility in Young Individuals With Non-Specific Low Backache","Inclusion Criteria:\n\n* Age 18-25\n* Non-specific low backache of pain severity less than and equal to 5\u002F10 on Brief Pain Inventory Scale\n* Ability to attend complete six-week program\n* Both genders\n\nExclusion Criteria:\n\n* prior history of trauma, fracture, spinal stenosis, severe comorbidities, spinal surgery and neurological disorders\n* Individuals suffering from specific causes of low backache like Infection and pregnancy","25 Years",{"count":213,"type":23},[26],"The aim of this clinical trial is to study the effects of Pilates intervention versus conventional therapy on postural correction, core strength and flexibility in young individuals with complaint of non-specific low backache. The main question is whether the Pilates has better improvement as compared to the conventional therapy on postural correction, core strength and flexibility moreover to compare the effectiveness of two intervention. Participants of age 18-25 years and with complaint of non-specific low backache will be recruited. 50 participants will be enrolled. Participants will perform Pilates and conventional therapy for 3 times per week for six weeks. Participants will be randomly allocated to two groups and assessor blinding will be done to take baseline assessment. Assessor blinding is done to minimize biasness. Pre and Post assessments will be taken by the assessor. SPSS will be used for the analysis of the data.",[260,261,262,263,264,265],"Low Back Pain","Postural Control","Core Strength","Flexibility","Pilates","Non-specific Low Back Pain",[264,267,268,269,270,271,272],"core strength","flexibility","postural correction","young individuals","Non-specific low backache","low back pain","2026-03-07",{"date":275,"type":41},"2026-03-12",{"date":277,"type":41},"2026-03-03",{"date":279,"type":23},"2026-04-20",{"name":47,"class":48},{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":57,"sex":211,"minAge":19,"maxAge":255,"enrollmentInfo":288,"targetDuration":4,"studyType":24,"phases":290,"briefSummary":291,"conditions":292,"keywords":296,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":303,"lastUpdatePostDateStruct":304,"startDateStruct":306,"completionDateStruct":308,"leadSponsor":310,"locationsCount":49},"100628443","study-of-15-versus-30-velocity-loss-thresholds-during-bodyweight-squats-and-their-effects-on-strength-and-endurance-in-young-women-100628443","NCT07461701","Study of 15% Versus 30% Velocity Loss Thresholds During Bodyweight Squats and Their Effects on Strength and Endurance in Young Women","Effect of 15% Versus 30% Intra-Set Velocity Loss Thresholds During Bodyweight Squats on Lower-Limb Strength and Muscular Endurance in Non-Athletic Young Female Adults.","Inclusion Criteria:\n\n* Female participants\n* 18-25 Years\n* Body Mass Index less than 30 kg\u002Fm²\n* Low physical activity level\n* Able to perform body weight squats without pain or assistance\n\nExclusion Criteria:\n\n* Recent Cardiovascular Disease\n* Current Patellar Injury\n* Recent Musculoskeletal Injuries\n* Current Pregnancy or Postpartum Period within the last 6 months\n* Participation in resistance or endurance training programs in the past 6 months.",{"count":289,"type":23},52,[26],"The goal of this clinical trial is to learn how two different velocity loss thresholds (15% and 30%) during bodyweight squats affect strength and endurance in non-athletic young women aged 18-25 years.\n\nThe main questions it aims to answer are:\n\nDoes a lower velocity loss threshold (15%) during bodyweight squats improve lower-limb strength? Does a higher velocity loss threshold (30%) during bodyweight squats improve muscular endurance? Researchers will compare the two groups (15% vs. 30% velocity loss) to see if one approach works better for strength and endurance.\n\nParticipants will:\n\nPerform bodyweight squats three times per week for six weeks. Be randomly assigned to either the 15% or 30% velocity loss group. Complete strength and endurance tests before and after the program",[293,294,295],"Lower-Limb Strength","Muscular Endurance","Velocity-Based Resistance Training",[297,298,293,294,299,300,301,302],"Velocity Loss Thresholds","Bodyweight Squats","Non-Athletic Young Women","Resistance Training","Physiotherapy Exercise Prescription","Randomized Controlled Trial","2026-03-04",{"date":305,"type":41},"2026-03-10",{"date":307,"type":41},"2026-02-22",{"date":309,"type":23},"2026-04-19",{"name":47,"class":48},{"id":312,"slug":313,"hasResults":12,"nctId":314,"briefTitle":315,"officialTitle":316,"acronym":4,"eligibilityCriteria":317,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":318,"enrollmentInfo":319,"targetDuration":4,"studyType":24,"phases":321,"briefSummary":322,"conditions":323,"keywords":325,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":332,"lastUpdatePostDateStruct":333,"startDateStruct":334,"completionDateStruct":335,"leadSponsor":337,"locationsCount":76},"100627090","effect-of-myofascial-release-therapy-on-university-students-with-text-neck-syndrome-100627090","NCT07444112","Effect of Myofascial Release Therapy on University Students With Text Neck Syndrome.","Effect of Myofascial Release Therapy on Neck Pain, Perceived Stress and Forward Head Posture in University Students With Text Neck Syndrome.","Inclusion Criteria:\n\n* 1\\. university students from age group of 18-30 2. Both genders 3. Students with Text Neck Syndrome diagnosed via Forward head Posture (through measuring craniovertebral angle) \\\u003C50° 4. Minimum Pain measured by Visual Analog Scale (VAS) ≥ 3\u002F10 5. Pain Intensity measured through Neck Disability Index (NDI \\> 10%) 6. A PSS-10 Score of \\>14 in individuals with daily gadget use and FHP. 7. Usage of handheld digital gadgets including smartphones and tablets ≥ 3 hours\n\nExclusion Criteria:\n\n* 1\\. History of cervical trauma, surgery or any spine deformity which is congenital 2. History of diagnosed cervical disorders i.e cervical spondylosis, cervical spondylolisthesis, disc herniation 3. Any diagnosed neurological condition which affects cognition or any previous cervical spine surgery 4. Any history of diagnosed anxiety and psychiatric conditions 5. Currently receiving any form of physical therapy or using any muscle relaxants or painkillers","30 Years",{"count":320,"type":23},62,[26],"This randomized controlled trial aims to determine the effectiveness of myofascial release therapy in university students with text neck syndrome as prolonged smartphone and digital gadgets use has been associated with neck pain, forward head posture, and increased perceived stress among young adults with screen time more than 3 hours. Participants will be randomly allocated into control group and intervention group and will be treated for 4 weeks. Clinical outcomes including neck pain, neck pain intensity, craniovertebral angle for posture assessment, and perceived stress levels will be measured at baseline and post-intervention. The study seeks to determine whether Myofascial Release Therapy acts as a non-invasive technique in improving musculoskeletal and psychosocial parameters related to text neck.",[324],"Text Neck Syndrome",[326,327,328,329,330,331],"text neck syndrome","neck pain","forward head posture","perceived stress","myofascial release therapy","randomized controlled trial","2026-02-24",{"date":72,"type":41},{"date":307,"type":41},{"date":336,"type":23},"2026-04-05",{"name":47,"class":48},{"id":339,"slug":340,"hasResults":12,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":12,"sex":18,"minAge":345,"maxAge":346,"enrollmentInfo":347,"targetDuration":4,"studyType":24,"phases":349,"briefSummary":350,"conditions":351,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":354,"startDateStruct":356,"completionDateStruct":357,"leadSponsor":358,"locationsCount":4},"100626684","continuous-sedation-vs-daily-sedation-interruption-in-ventilated-children-100626684","NCT07438834","Continuous Sedation vs Daily Sedation Interruption in Ventilated Children","Comparison of Comfort Scores Between Continuous Midazolam Infusion and Daily Sedation Interruption in Mechanically Ventilated Pediatric Patients With Pneumonia: A Randomized Controlled Trial","Inclusion Criteria:\n\nDiagnosed with pneumonia\n\nRequiring mechanical ventilation for at least 48 hours\n\nRequiring sedation with intravenous Midazolam\n\nWritten informed consent obtained from parent or legal guardian\n\nExclusion Criteria:\n\nPre-existing neurological impairment (e.g., traumatic brain injury, stroke, cerebral palsy) that may interfere with comfort assessment\n\nPresence of central nervous system symptoms affecting sedation evaluation\n\nContraindication to Midazolam (e.g., hypersensitivity, severe hypotension, significant hepatic dysfunction)\n\nReceiving multiple sedative agents in addition to Midazolam\n\nRefusal of parental or guardian consent","5 Years","10 Years",{"count":348,"type":23},96,[26],"Sedation is essential for mechanically ventilated pediatric patients to ensure comfort, ventilator synchrony, and prevention of self-extubation. However, excessive sedation may prolong mechanical ventilation and ICU stay, while inadequate sedation may cause agitation and physiological distress. Continuous Sedation Infusion (CSI) and Daily Sedation Interruption (DSI) are two commonly used strategies. Limited data exist comparing their impact on comfort levels in pediatric patients.\n\nThis randomized controlled trial aims to compare comfort scores between continuous Midazolam infusion and daily sedation interruption in mechanically ventilated children aged 5-10 years diagnosed with pneumonia. Comfort will be assessed using the COMFORT-B Scale and Richmond Agitation-Sedation Scale (RASS) every 6 hours for 72 hours.\n\nThe study intends to determine which strategy better maintains optimal sedation and comfort in pediatric intensive care settings.",[352,353],"Pneumonia","Respiration Disorders",{"date":355,"type":41},"2026-02-27",{"date":72,"type":23},{"date":129,"type":23},{"name":47,"class":48},{"id":360,"slug":361,"hasResults":12,"nctId":362,"briefTitle":363,"officialTitle":364,"acronym":4,"eligibilityCriteria":365,"healthyVolunteers":57,"sex":211,"minAge":19,"maxAge":108,"enrollmentInfo":366,"targetDuration":4,"studyType":24,"phases":367,"briefSummary":368,"conditions":369,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":371,"lastUpdatePostDateStruct":372,"startDateStruct":374,"completionDateStruct":376,"leadSponsor":378,"locationsCount":49},"100622380","to-investigate-impact-of-diet-and-physical-activity-based-nurse-led-interventions-on-maternal-outcomes-and-neonatal-outcomes-in-women-with-gestational-diabetes-mellitus-gdm-100622380","NCT07382869","to Investigate Impact of Diet and Physical Activity Based Nurse Led Interventions on Maternal Outcomes and Neonatal Outcomes in Women With Gestational Diabetes Mellitus (GDM)","Impact of Diet and Physical Activity Based Nurse Led Interventions on Maternal Outcome and Neonatal Outcomes in Women With Gestational Diabetes Mellitus (GDM): A Randomized Controlled Trial","Inclusion Criteria:\n\nPregnant women aged 18-40 years\n\n* Diagnosed with GDM in the indexed pregnancy\n* Singleton pregnancy. Pregnant women with gravida 02.\n\nExclusion Criteria:\n\n* Pre-existing diabetes mellitus (Type 1 or Type 2)\n* Multiple pregnancies (twins, triplets, etc.)\n* Women with history of Pregnancy induced hypertension. (PIH)\n* History of chronic medical conditions (renal disease, cardiac disorders, epilepsy)\n* Psychiatric illness or cognitive impairment that may affect participation",{"count":60,"type":23},[26],"Gestational Diabetes Mellitus (GDM) is a growing maternal health concern associated with adverse neonatal outcomes such as macrosomia and shoulder dystocia, often aggravated by poor dietary habits and physical inactivity during pregnancy. This randomized controlled study aims to evaluate the effectiveness of structured nursing interventions focusing on diet and physical activity in improving maternal glycemic control and reducing neonatal complications. A total of 66 pregnant women diagnosed with GDM will be selected through purposive sampling and randomly allocated into intervention and control groups using the lottery method. The intervention group will receive individualized dietary counselling, pregnancy-appropriate physical activity guidance, and regular nursing follow-up, while the control group will continue with routine antenatal care. Maternal outcomes, including fasting blood glucose and HbA1c levels, will be measured at baseline and follow-up visits. Neonatal outcomes such as macrosomia, mode of delivery, and shoulder dystocia will be documented at birth. Data will be collected using structured tools and analysed using SPSS, with independent t-tests and chi-square tests applied. The study anticipates that structured nursing interventions will significantly improve glycaemic control and reduce adverse neonatal outcomes, supporting the integration of evidence-based nursing care into routine GDM management.",[370],"Gestatiaonl Diabetes Mellitus","2026-02-08",{"date":373,"type":41},"2026-02-11",{"date":375,"type":23},"2026-03-01",{"date":377,"type":23},"2026-09-30",{"name":47,"class":48},{"id":380,"slug":381,"hasResults":12,"nctId":382,"briefTitle":383,"officialTitle":384,"acronym":4,"eligibilityCriteria":385,"healthyVolunteers":12,"sex":18,"minAge":166,"maxAge":386,"enrollmentInfo":387,"targetDuration":4,"studyType":24,"phases":389,"briefSummary":390,"conditions":391,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":394,"startDateStruct":396,"completionDateStruct":398,"leadSponsor":400,"locationsCount":4},"100621646","vinegar-vs-normal-saline-dressing-for-diabetic-foot-ulcers-100621646","NCT07373327","Vinegar vs Normal Saline Dressing for Diabetic Foot Ulcers","A Randomized Clinical Trial to Compare the Efficacy of Vinegar Dressing Versus Normal Saline Dressing in the Treatment of Diabetic Foot Ulcers","Inclusion Criteria:\n\n* Age: 20 to 65 years.\n* Gender: Both male and female participants are included.\n* Condition: Patients with Grade 3 and 4 infected diabetic foot ulcers (DFU) according to the Wagner classification.\n\nExclusion Criteria:\n\n* Wagner Grades 1, 2, 5, and 6 diabetic foot ulcers.\n* History of Radiotherapy.\n* History of Chemotherapy.\n* Use of Steroids.\n* Use of Immunosuppressive drugs.\n* Allergy to vinegar.","65 Years",{"count":388,"type":23},84,[26],"This study is investigating the effectiveness of two different types of wound dressings in treating diabetic foot ulcers (DFUs), a common complication of diabetes that can be difficult to heal. The study will compare the use of vinegar dressings to normal saline (saltwater) dressings to see which one helps heal the wound faster and more effectively.\n\nPeople with diabetic foot ulcers often struggle with infections and slow healing. The goal of this study is to determine if vinegar, a simple and affordable treatment, works better than saline in improving wound healing and reducing infections. The study will measure how quickly the wound heals, how much dead tissue is removed, and whether the bacteria in the wound disappear.\n\nThis study will involve patients with infected diabetic foot ulcers. Participants will be randomly assigned to receive either vinegar or saline dressing. The results will help determine the best and most cost-effective treatment for diabetic foot ulcers, potentially making it easier for patients to access better care.",[392],"Diabetic Foot Ulcer (DFU)","2026-01-19",{"date":395,"type":41},"2026-01-28",{"date":397,"type":23},"2026-02-04",{"date":399,"type":23},"2026-08-01",{"name":47,"class":48},{"id":402,"slug":403,"hasResults":12,"nctId":404,"briefTitle":405,"officialTitle":406,"acronym":4,"eligibilityCriteria":407,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":24,"phases":411,"briefSummary":412,"conditions":413,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":415,"startDateStruct":416,"completionDateStruct":418,"leadSponsor":420,"locationsCount":4},"100621645","modified-vs-conventional-laparoscopic-tapp-for-inguinal-hernia-100621645","NCT07373314","Modified vs. Conventional Laparoscopic TAPP for Inguinal Hernia","A Randomized Controlled Trial Comparing Modified Tumescent vs. Conventional Laparoscopic TAPP for Inguinal Hernia Repair","Inclusion Criteria:\n\n* Age: 18 to 50 years.\n* Gender: Both male and female participants.\n* Condition: Diagnosed with unilateral inguinal hernia (as per operational definition).\n* Health Status: ASA I-III (American Society of Anesthesiologists physical status classification), indicating that the patient is fit for surgery.\n* Consent: Participants must be able to provide informed consent to participate in the study.\n\nExclusion Criteria:\n\n* Femoral Hernias.\n* Incarcerated or Strangulated Hernia.\n* Recurrent Hernias (as per medical record).\n* Serious Systemic Diseases:\n* Conditions such as heart failure or coagulation problems (e.g., PT \\> 15 sec).\n* ASA III-V classification, indicating a higher risk for surgery.\n* Pregnancy (if applicable).\n* Allergy to Anesthesia or the substances used in the tumescent solution (lidocaine, epinephrine, saline).\n* Uncontrolled Diabetes or other medical conditions that might interfere with the healing process.","50 Years",{"count":410,"type":23},60,[26],"This study aims to compare the outcomes of two laparoscopic techniques for repairing inguinal hernias: the modified tumescent technique (MT-TAPP) and the conventional laparoscopic transabdominal preperitoneal technique (CL-TAPP). The primary goal is to determine which technique provides better outcomes in terms of operative time, ease of pre-peritoneal space dissection, postoperative pain, and the formation of seromas. The study will involve 60 patients diagnosed with unilateral inguinal hernias, randomly assigned to either group. Participants in Group A will undergo the MT-TAPP procedure, which involves pre-peritoneal infiltration of a local anesthetic solution to improve dissection and reduce pain. Group B will undergo the standard CL-TAPP procedure. Data will be collected on various outcome measures and analyzed to identify which technique leads to quicker recovery, less postoperative pain, and fewer complications. The results of this study will help guide surgical decisions and improve patient outcomes in inguinal hernia repair.",[414],"Inguinal Hernia Repair",{"date":395,"type":41},{"date":417,"type":23},"2026-02-10",{"date":419,"type":23},"2026-08-30",{"name":47,"class":48},{"id":422,"slug":423,"hasResults":12,"nctId":424,"briefTitle":425,"officialTitle":426,"acronym":4,"eligibilityCriteria":427,"healthyVolunteers":12,"sex":18,"minAge":428,"maxAge":20,"enrollmentInfo":429,"targetDuration":4,"studyType":24,"phases":431,"briefSummary":432,"conditions":433,"keywords":435,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":393,"lastUpdatePostDateStruct":441,"startDateStruct":442,"completionDateStruct":444,"leadSponsor":446,"locationsCount":49},"100621588","pressurized-meter-dose-inhaler-vs-dry-powder-inhaler-100621588","NCT07372573","Pressurized Meter Dose Inhaler V\u002FS Dry Powder Inhaler","Effectivenes of Pressurized Meter Dose Inhaler (PMDI) Versus Dry Powder Inhaler (DPI) in Delivering Inhaled Corticosteroid and Long Acting Beta Agonist Among Patients With Uncontrolled Asthma in a Tertiary Care Hospital.","Inclusion Criteria:\n\nAge 14 to 60 years\n\nBoth genders\n\nAll patients with symptoms of uncontrolled asthma\n\nExclusion Criteria:\n\nPatients with coexistent fungal sensitization (confirmed with peripheral eosinophil count and serum IgE)\n\nPatients with coexistent Allergic Bronchopulmonary Aspergillosis (ABPA) (confirmed with HRCT and serum IgE)\n\nPatients with coexistent COPD (confirmed on spirometry)\n\nPatients with Hypersensitivity Pneumonitis\n\nPatients with coexistent Interstitial Lung Disease (ILD) (confirmed on spirometry)\n\nPatients with coexistent cardiac asthma secondary to heart failure (diagnosed on echocardiography)","14 Years",{"count":430,"type":23},210,[26],"This study compares two commonly used inhalation devices in asthma management. It focuses on evaluating how effectively PMDIs and DPIs deliver the same combination of inhaled corticosteroids and long-acting beta agonists in patients whose asthma remains poorly controlled despite treatment. The study is conducted in a tertiary care hospital setting, emphasizing real-world clinical practice and aiming to determine whether device choice influences asthma control outcomes.",[434],"Asthma (Diagnosis)",[436,437,438,439,440],"Asthma","Pressrized Meter Dose inhaler","Dry powder Inhaler","long acting beta Agonist","inhaled corticosteroid",{"date":395,"type":41},{"date":443,"type":23},"2026-02-01",{"date":445,"type":23},"2026-07-31",{"name":47,"class":48},{"id":448,"slug":449,"hasResults":12,"nctId":450,"briefTitle":451,"officialTitle":452,"acronym":4,"eligibilityCriteria":453,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":108,"enrollmentInfo":454,"targetDuration":4,"studyType":24,"phases":456,"briefSummary":457,"conditions":458,"keywords":4,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":49},"100619950","the-effect-of-platelet-rich-fibrin-on-sensitivity-and-periodontal-pockets-distal-to-second-molar-after-surgical-extraction-of-impacted-third-molar-100619950","NCT07351279","The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar","\" The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar \"","Inclusion Criteria:\n\n* Impacted third molar (as per Operational Definition) with fully erupted second molars bilaterally.\n* Impacted Third molar with Class 2 and Level B according to Pell and Gregory's classification (Annexure B) with mesioangular or horizontal angulation of impaction\n* Periodontal pocket depth \\> 4mm and Clinical attachment loss \\> 1mm at distal side of second molar\n* Age 18-40 years, both genders.\n* Patients who give informed consent.\n\nExclusion Criteria:\n\n* Any Systemic Disease i.e. Uncontrolled Diabetes mellitus, Uncontrolled hypertension, Ischemic heart disease, bleeding disorders, Autoimmune diseases or immunocompromised patients\n* Decayed or recommended for extraction second molars on either side.\n* Allergic to Amoxicillin to standardize Antibiotic therapy protocol.\n* Untreated periodontal condition.\n* Inability to follow up.",{"count":455,"type":23},56,[26],"Surgical extraction of impacted third molar is the most common surgical procedure performed in oral and maxillofacial surgery. The immediate post operative complications after 3rd molar surgery are pain, swelling and trismus while delayed post operative complications are mostly seen on the distal surface of second molar due to distal bone loss which include prolonged sensitivity due to increased periodontal pocket depth, gingival recession and root exposure.\n\nWhen PRF clot is given in wound, it causes alterations of the cellular ratios in the wound blood clot, leading to replacement of blood cells with Platelets and growth factors stimulating all phases of healing which will improve the immidiate and delayed post operative complications The purpose of present study is to compare the clinical outcomes in the treatment of senstivity and periodontal pockets at the distal aspect of second molar following surgical extraction of impacted third molar using PRF or Blood clot alone.",[459,460],"Third Molar Impaction","Surgical Extraction of Impacted Third Molars","2026-01-11",{"date":463,"type":41},"2026-01-20",{"date":465,"type":23},"2026-02",{"date":467,"type":23},"2028-02",{"name":47,"class":48},{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":24,"phases":478,"briefSummary":479,"conditions":480,"keywords":484,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":491,"startDateStruct":493,"completionDateStruct":495,"leadSponsor":497,"locationsCount":49},"100618930","the-buzdar-technique-100618930","NCT07338019","The Buzdar Technique","The Buzdar Technique for Pulmonary Parenchymal Chest Tube Removal: Prospective Evaluation of a Novel Minimally Invasive Protocol","Inclusion Criteria:\n\n* Patients ≥18 years with confirmed intraparenchymal chest tube placement on chest CT or X-ray.\n* Hemodynamically stable patients suitable for conservative staged removal.\n* Patients providing informed consent.\n\nExclusion Criteria:\n\n* Patients requiring immediate thoracotomy due to massive bleeding or large bronchopleural fistula.\n* Patients with uncorrectable coagulopathy or unstable cardiopulmonary status.\n* Patients refusing participation or lost to follow-up.",{"count":477,"type":23},300,[26],"Chest tube thoracostomy remains a lifesaving intervention in trauma and thoracic surgery, used for the management of pneumothorax, hemothorax, empyema, and pleural effusions. Despite being one of the most frequently performed procedures worldwide, complication rates remain high, ranging from 20% to 40% \\[1\\]. Among these, pulmonary parenchymal chest tube (PPcT) insertion represents a rare but potentially devastating event, leading to hemorrhage, air leak, bronchopleural fistula, or infection. In Pakistan, where chest trauma and pneumothorax constitute major thoracic morbidities, PPcT cases are encountered with increasing frequency but remain underreported. Current literature describes only invasive surgical approaches-such as thoracotomy or video-assisted thoracic surgery (VATS)-for PPcT removal \\[9,10\\], with no established minimally invasive alternatives.\n\nIn response to this clinical challenge, the Department of Thoracic Surgery at (Hospital Name), Punjab, Pakistan, has developed and implemented a novel, minimally invasive three-stage removal technique, termed the Buzdar Technique, designed to ensure safe extraction of intraparenchymal chest tubes without surgical intervention. The technique follows a standardized protocol involving:\n\nHealing phase: Tube left in situ for approximately two weeks to allow localized fibrosis and stabilization of the lung parenchyma.\n\nInitial retraction: Gradual 2-cm withdrawal with optional 360° rotation under radiologic and clinical supervision, followed by 24-hour observation and chest imaging.\n\nSequential retractions: Weekly staged retractions of 2 cm until the last fenestration exits the pleural cavity, enabling safe final removal.\n\nThis prospective cohort study, conducted from July 2025 to June 2026, aims to evaluate the safety, effectiveness, and clinical outcomes of the Buzdar Technique in managing iatrogenic PPcT. Data will include patient demographics, procedural details, complications, radiologic recovery, and overall outcomes. Success will be defined as complete tube removal without pneumothorax, air leak, bleeding, or need for surgical intervention.\n\nPreliminary institutional experience over the past decade has shown excellent results, with minimal morbidity, no requirement for thoracotomy or VATS, and full radiologic recovery in the majority of patients. The expected outcomes of this prospective evaluation are to validate these findings, establish the Buzdar Technique as a reproducible, evidence-based approach, and contribute to the global literature on non-surgical management of PPcT.\n\nIf proven effective, this technique could represent a paradigm shift in the management of intraparenchymal chest tubes-offering a safe, staged, and minimally invasive alternative to surgical removal, particularly beneficial for centers in low- and middle-income countries where advanced surgical options may not always be available.",[481,482,483],"Chest Tube Management","Chest Tube Withdrawal","Iatrogenic Injury",[485,486,487,488,489],"Pulmonary parenchymal chest tube (PPcT)","chest tube malposition","tube thoracostomy complication","Buzdar technique","staged withdrawal","2026-01-03",{"date":492,"type":41},"2026-01-13",{"date":494,"type":41},"2025-07-01",{"date":496,"type":23},"2027-09-30",{"name":47,"class":48},{"id":499,"slug":500,"hasResults":12,"nctId":501,"briefTitle":502,"officialTitle":503,"acronym":4,"eligibilityCriteria":504,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":505,"targetDuration":4,"studyType":24,"phases":506,"briefSummary":507,"conditions":508,"keywords":512,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":519,"startDateStruct":520,"completionDateStruct":522,"leadSponsor":524,"locationsCount":49},"100618929","chest-wall-reconstruction-cohort-100618929","NCT07338006","Chest Wall Reconstruction Cohort","Comparative Outcomes of Chest Wall Reconstruction Using Twisted Steel Wires Versus Bone Cement: A Cohort Study","Inclusion Criteria:\n\n* Patients aged ≥18 years undergoing partial or full-thickness chest wall resection.\n* Defects requiring rigid or semi-rigid reconstruction involving two or more ribs or the sternum.\n\nExclusion Criteria:\n\n* Patients with small defects managed by primary closure or soft tissue-only reconstruction.\n* Patients with concurrent major intrathoracic resections (e.g., pneumonectomy) may confound postoperative respiratory assessment.\n* Recurrent disease requiring revision reconstruction.\n* Patients unwilling or unable to provide consent or comply with follow-up.",{"count":213,"type":23},[26],"Chest wall reconstruction following tumor or infection-related resections remains a challenging aspect of thoracic surgery, requiring restoration of structural stability and preservation of respiratory mechanics. While polymethyl methacrylate (PMMA) bone cement has long been used for rigid reconstruction, its limitations-including high cost, rigidity, infection risk, and interference with normal respiratory motion-pose challenges in resource-constrained settings. Twisted stainless steel wires offer a low-cost, flexible alternative that allows dynamic chest wall movement and easier adaptability in low- and middle-income countries such as Pakistan.\n\nTo compare postoperative outcomes, complications, and cost-effectiveness of chest wall reconstruction using twisted stainless steel wires versus PMMA bone cement over a two-year period (January 2025 - December 2026).\n\nThis prospective cohort study was conducted in the Department of Thoracic Surgery, Services Hospital, Lahore, a high-volume tertiary care and referral center. Patients undergoing chest wall reconstruction following resection for tumors, infections, or trauma were enrolled and divided into two groups based on the reconstruction technique used: Group A (twisted steel wires) and Group B (PMMA bone cement). Parameters assessed included postoperative pain (VAS scores), respiratory function, chest wall stability, complications (infection, wound dehiscence, prosthesis exposure), duration of hospital stay, readmission rate, and cost of reconstruction. Data were analyzed to compare clinical and functional outcomes between both cohorts.",[509,510,511],"Chest Wall Tumor","Reconstructive Surgical Procedure","Malignancy",[513,514,515,516,517,518],"Chest wall reconstruction","Bone cement","Stainless steel wire","Thoracic surgery","Postoperative pain","Functional outcomes",{"date":492,"type":41},{"date":521,"type":41},"2021-01-01",{"date":523,"type":23},"2027-03-31",{"name":47,"class":48},{"id":526,"slug":527,"hasResults":12,"nctId":528,"briefTitle":529,"officialTitle":530,"acronym":4,"eligibilityCriteria":531,"healthyVolunteers":12,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":532,"targetDuration":4,"studyType":24,"phases":533,"briefSummary":534,"conditions":535,"keywords":539,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":543,"startDateStruct":544,"completionDateStruct":545,"leadSponsor":546,"locationsCount":49},"100618928","fungal-empyema-thoracis-100618928","NCT07337993","Fungal Empyema Thoracis","Efficacy of Pleural Lavage With Antifungals in the Management of Fungal Empyema Thoracis: A Prospective Cohort Study","Inclusion Criteria:\n\n* All age patients with confirmed fungal empyema thoracis.\n* Patients with adequate pleural drainage through an intercostal chest tube.\n* Patients receiving systemic antifungal therapy.\n* Patients either:\n\n  1. scheduled for surgical decortication but undergoing lavage as a preoperative adjunct, or\n  2. considered unfit for surgery and managed conservatively.\n\nExclusion Criteria:\n\n* Bacterial empyema without fungal growth.\n* Known hypersensitivity to anti-fungals.\n* Severe hepatic impairment (Child-Pugh class C) contraindicating voriconazole.\n* Pregnancy or lactation.\n* Refusal to participate.",{"count":213,"type":23},[26],"Background:\n\nFungal empyema thoracis is a rare but life-threatening pleural infection caused by fungal organisms such as Aspergillus and Candida species. It typically occurs in immunocompromised or debilitated patients and carries a high mortality rate. Conventional management involves systemic antifungal therapy and surgical decortication; however, many patients are unfit for surgery due to poor clinical status or multiple comorbidities. The use of local intrapleural antifungal therapy remains poorly studied.\n\nObjective:\n\nThis study aims to evaluate the efficacy and safety of pleural lavage with voriconazole in patients with fungal empyema thoracis, both as a pre-surgical adjunct and as a palliative measure for patients who cannot undergo surgery.\n\nMethods:\n\nA prospective cohort study will be conducted at the Department of Thoracic Surgery, Services Hospital, Lahore. Patients diagnosed with fungal empyema confirmed by pleural fluid culture or cytology will be included. Through an indwelling chest tube, voriconazole (200 mg in 100 mL normal saline) will be instilled into the pleural cavity once daily for three consecutive days. Patients will be assessed for improvement in clinical symptoms, radiological clearance, reduction in fungal load, and the need for surgical intervention. Data will be statistically analyzed to determine treatment response and safety outcomes.\n\nConclusion:\n\nPleural lavage with voriconazole offers a promising, minimally invasive approach for managing fungal empyema thoracis. If proven effective, this method could serve as a valuable addition to current antifungal strategies, improving outcomes for critically ill patients who are not candidates for surgery.",[536,537,538],"Pyothorax","Fungal Infection Lungs","Pleural Empyema",[540,541,542],"Fungal Pyothorax","pleural lavage","anti-fungals",{"date":492,"type":41},{"date":494,"type":41},{"date":523,"type":23},{"name":47,"class":48},{"id":548,"slug":549,"hasResults":12,"nctId":550,"briefTitle":551,"officialTitle":551,"acronym":4,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":18,"minAge":553,"maxAge":4,"enrollmentInfo":554,"targetDuration":4,"studyType":24,"phases":556,"briefSummary":557,"conditions":558,"keywords":563,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":490,"lastUpdatePostDateStruct":568,"startDateStruct":570,"completionDateStruct":571,"leadSponsor":573,"locationsCount":49},"100605858","comparison-of-talc-slurry-versus-talc-insufflation-a-study-on-effectiveness-safety-and-hospital-outcomes-in-pleurodesis-100605858","NCT07167992","Comparison of Talc Slurry Versus Talc Insufflation: A Study on Effectiveness, Safety, and Hospital Outcomes in Pleurodesis","Inclusion Criteria:\n\n* patients aged 12 years and older.\n* Diagnosed with malignant pleural effusions or pneumothoraces.\n* ECOG performance status of 0-2.\n* Life expectancy of at least 3 months.\n* Ability to provide informed consent.\n* No contraindications to general anesthesia or conscious sedation.\n\nExclusion Criteria:\n\n* Patients younger than 12 years old\n* Female patients who are pregnant or lactating\n* Patients with encysted or septated pleural effusions and pneumothoraces\n* Patients presenting with respiratory failure\n* Patients complaining of dyspnea in spite of complete evacuation of pleural effusion or pneumothorax.\n* Patients with evident chest infection with clinical or laboratory signs suggestive of parapneumonic effusions.","12 Years",{"count":555,"type":23},160,[26],"Pleural effusion is characterized by the accumulation of fluid in the pleural space, which typically contains about 10-20 mL of pleural fluid that is crucial for the movement of the lungs against the chest wall. This fluid closely resembles plasma but has a lower protein concentration, usually less than 1.5 gm\u002FdL. It primarily originates from pleural capillaries and the interstitial spaces of the lung, and is reabsorbed through the lymphatic vessels in the parietal pleura, either via small openings known as stomas or through a process called transcytosis (1, 2). When the balance between fluid production and reabsorption is disrupted-often due to various pathogenic mechanisms-it can lead to pleural effusion. In such cases, effective management is essential. This study aims to conduct a thorough comparison of the two talc administration methods-TS and TI-using sterilized, large-particle, asbestos-free talc powder. By examining key outcome measures such as pleurodesis success rates, procedural morbidity, and length of hospital stay, the goal is to provide clinicians with evidence-based guidance to facilitate informed decision-making in the management of pleural effusions.",[559,560,561,562],"Pneumothorax Spontaneous Primary","Pneumothorax Spontaneous Secondary","Pleural Effusion, Malignant","Pleurodesis",[564,565,562,566,567],"Talc slurry","Talc Insufflation","malignant pleural effusions","recurrent pneumothorax",{"date":569,"type":41},"2026-01-06",{"date":443,"type":23},{"date":572,"type":23},"2027-03-30",{"name":47,"class":48},{"id":575,"slug":576,"hasResults":12,"nctId":577,"briefTitle":578,"officialTitle":579,"acronym":4,"eligibilityCriteria":580,"healthyVolunteers":57,"sex":18,"minAge":581,"maxAge":139,"enrollmentInfo":582,"targetDuration":4,"studyType":24,"phases":583,"briefSummary":585,"conditions":586,"keywords":589,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":599,"lastUpdatePostDateStruct":600,"startDateStruct":601,"completionDateStruct":602,"leadSponsor":604,"locationsCount":4},"100615235","phase-3-comparative-evaluation-of-clinical-and-radiographic-treatment-outcomes-of-garlic-gel-and-calcium-hydroxide-as-an-intracanal-medicament-in-nonsurgical-root-canal-treatment-of-permanent-teeth-100615235","NCT07289971","Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth.","Comparative Evaluation of Clinical and Radiographic Treatment Outcomes of Garlic Gel and Calcium Hydroxide as an Intracanal Medicament in Nonsurgical Root Canal Treatment of Permanent Teeth: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Patients with the physical status of ASA I and ASA II according to ASA classification.\n* Patients aged from 15-45 years.\n* Mature permanent single-rooted teeth with closed apices.\n* Patients with clinical signs of symptomatic apical periodontitis (pain, tenderness to palpation, and percussion).\n* Patients having radiographic evidence of periapical radiolucency of endodontic origin.\n* Patients who have not taken antibiotics for the past 14 days.\n* Cooperative patients who show good compliance.\n\nExclusion Criteria:\n\n* Patients with physical status of ASA III, IV, and V according to ASA classification.\n* Teeth with a calcified pulp chamber in periapical radiography.\n* Patients who have undergone previous endodontic treatment failure and those with the presence of sinus tract on clinical examination.\n* Teeth having advanced periodontal disease, with the basic periodontal examination (BPE) of 3 and 4.\n* Presence of internal and external resorption of the root as viewed on the periapical radiograph.\n* Presence of vertical root fracture and perforation as viewed on the periapical radiograph","15 Years",{"count":348,"type":23},[584],"PHASE3","Researchers want to check how well garlic works inside permanent teeth as a medicament during root canal treatments. Garlic has shown to possess many helpful properties, like reducing inflammation, helping wounds heal, and antimicrobial characteristics. Because conventional medicaments can be expensive or have potential side effects, researchers are actively exploring natural options like garlic. Some lab studies have already shown that garlic gel can kill the microbes inside the teeth. However, no real-life clinical or X-ray studies have been done on using garlic in permanent teeth. This study may help scientists find a much safer and effective new material for dental treatments in the future.",[587,588],"Apical Periodontitis","Periapical Radiolucency",[590,591,592,593,594,595,596,597,598],"Intracanal Medicament","Allium Sativum","Calcium hydroxide","Root canal treatment","Periapical Index","Resolution of Periapical Radiolucency","Visual Analogue Scale","Palpation","Percussion","2026-01-01",{"date":569,"type":41},{"date":463,"type":23},{"date":603,"type":23},"2026-05",{"name":47,"class":48},{"id":606,"slug":607,"hasResults":12,"nctId":608,"briefTitle":609,"officialTitle":609,"acronym":610,"eligibilityCriteria":611,"healthyVolunteers":12,"sex":18,"minAge":581,"maxAge":108,"enrollmentInfo":612,"targetDuration":4,"studyType":24,"phases":614,"briefSummary":615,"conditions":616,"keywords":619,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":622,"lastUpdatePostDateStruct":623,"startDateStruct":624,"completionDateStruct":626,"leadSponsor":628,"locationsCount":49},"100617517","efficacy-of-platelet-rich-fibrin-prf-in-neurosensory-disturbance-among-patients-with-mandibular-body-fractures-100617517","NCT07319650","Efficacy Of Platelet Rich Fibrin (PRF) In Neurosensory Disturbance Among Patients With Mandibular Body Fractures","PRF NSD","Inclusion Criteria:\n\n* Patients having neurosensory disturbance following mandibular body fracture involving mental foramen and pre-operative TPD discrimination score '0' or '1' will be selected in this study ( as per operational definition). TPD discrimination will be recorded; Preoperatively Immediately post operatively After 6 months\n\nAge 15-40years, Both Gender ASA\\_1\n\nExclusion Criteria:\n\n* Comminuted mandibular fractures Previously treated cases of fractures Patients with history of neurological disorders Comorbid patients",{"count":613,"type":23},40,[26],"Mandibular body fractures frequently result in inferior alveolar nerve (IAN) and mental nerve injuries which ultimately leads to paresthesia of chin and lower lip area. The objective of this study is to evaluate the efficacy of platelet rich fibrin (PRF) application to mental nerve during open reduction and internal fixation (ORIF) of patients having neurosensory disturbance (NSD) following mandibular body fracture involving mental foramen. The PRF application to mental nerve in mandibular body fractures will not only aid in hard and soft tissue healing but also prove to be a game changer for a holistic healing of a patient rather than separate surgical procedures for nerve repair such as microsurgery, grafting, tissue glues, laser.\n\nAlternate Hypothesis HA= The application of PRF to the mental nerve during open reduction and internal fixation of mandibular body fractures involving the mental foramen significantly improves neurosensory recovery compared to cases where PRF is not applied.\n\nNull Hypothesis HO= The application of PRF to the mental nerve during open reduction and internal fixation of mandibular body fractures involving the mental foramen does not significantly improve neurosensory recovery compared to cases where PRF is not applied.",[617,618],"Neurosensory Disturbance","Mandibular Body Fractures",[617,620,621],"Platelet Rich Fibrin","Mandibular body fractures","2025-12-20",{"date":569,"type":41},{"date":625,"type":23},"2026-01",{"date":627,"type":23},"2027-02",{"name":47,"class":48},{"id":630,"slug":631,"hasResults":12,"nctId":632,"briefTitle":633,"officialTitle":633,"acronym":4,"eligibilityCriteria":634,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":635,"targetDuration":4,"studyType":24,"phases":637,"briefSummary":638,"conditions":639,"keywords":4,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":643,"lastUpdatePostDateStruct":644,"startDateStruct":646,"completionDateStruct":648,"leadSponsor":650,"locationsCount":49},"100608248","comparative-efficacy-and-safety-of-acetazolamide-versus-metolazone-as-an-adjunct-to-standard-therapy-in-patients-with-acute-decompensated-heart-failure-100608248","NCT07199088","Comparative Efficacy and Safety of Acetazolamide Versus Metolazone as an Adjunct to Standard Therapy in Patients With Acute Decompensated Heart Failure","Inclusion Criteria:\n\n* Aged 18 years or older.\n* Diagnosed with Acute Decompensated Heart Failure (ADHF), with either preserved or reduced ejection fraction (EF).\n* At least one clinical sign of volume overload, such as:\n* Pleural effusion (confirmed by chest X-ray or ultrasound).\n* Oedema or ascites (verified by abdominal ultrasonography).\n* Plasma NT-proBNP level \\> 1000 pg\u002FmL or BNP level \\> 250 ng\u002FmL at screening.\n* Receiving at least 40 mg of furosemide as oral maintenance therapy for at least one month prior to the study initiation.\n\nExclusion Criteria:\n\n* Previous use of acetazolamide or metolazone prior to the study period.\n* Known hypersensitivity or allergies to the study drugs (acetazolamide or metolazone) or their components.\n* Patients with electrolyte disturbances, especially hypokalemia.\n* End-stage renal disease requiring dialysis or GFR \\\u003C 20 mL\u002Fmin\u002F1.73 m².\n* Pregnant or breastfeeding women.\n* Severe hypotension (systolic blood pressure \\\u003C 90 mmHg) or other significant comorbidities like congenital cardiac illness requiring surgery.\n* Patients requiring renal replacement therapy during the hospitalization.\n* History of significant electrolyte imbalances or acid-base disturbances.",{"count":636,"type":23},320,[26],"This clinical trial aims to compare the efficacy and safety of acetazolamide versus metolazone as adjunctive treatments to standard therapy in patients with acute decompensated heart failure (ADHF). ADHF is a life-threatening condition, and current treatments often involve loop diuretics to alleviate volume overload. This study will assess the added benefit of acetazolamide and metolazone in improving decongestion, reducing hospital stays, and preventing complications such as renal dysfunction or electrolyte imbalances. Participants will be randomized to receive either acetazolamide or metolazone in addition to standard diuretic therapy. The trial will evaluate primary outcomes including successful decongestion, in-hospital mortality, and length of hospital stay, with secondary outcomes focusing on renal function, electrolyte disturbances, and overall safety. The study is conducted at Bahawal Victoria Hospital, Bahawalpur, and aims to provide valuable insights into the management of ADHF, especially in the Pakistani population.",[640,641,642],"Acute Decompensated Heart Failure","Heart Failure, Diastolic","Heart Failure, Systolic","2025-09-29",{"date":645,"type":41},"2025-10-03",{"date":647,"type":23},"2025-10-11",{"date":649,"type":23},"2026-10-30",{"name":47,"class":48},""]