[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Houston\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":462},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,52,86,123,136,161,189,215,242,267,290,315,338,363,391,414,439],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100053274","phase-2-enhancing-smoking-cessation-for-african-american-people-everywhere-100053274",false,"NCT07024992","Enhancing Smoking Cessation for African American People Everywhere","A National Test of a Culturally Tailored Smartphone-based Smoking Cessation and Mental Health Intervention for Black Adults With HIV","ESCAPE","Inclusion Criteria:\n\n* At least 18 years of age\n* Identify as Black\u002FAfrican American\n* Living with HIV\n* Biochemical verification of self-reported smoking status following minimum study specified smoking rate endorsement\n* Motivated to quit smoking\n* Must be ready to quit cigarettes within 14 days of full enrollment\n* Moderate or higher anxiety sensitivity OR elevated anxiety OR depression\n* Must be willing to download a mobile app onto their personal phone\n* Must be willing to use NRT\n* Possess an Android\u002FApple smartphone that is compatible with the mobile app\n* Demonstrate 7th grade level proficiency in English (≥4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form \\[REALM-SF\\])\n* Valid proof of identification (photo of valid US ID)\n\nExclusion Criteria:\n\n* Legal situations which may interfere with study participation\n* Not being fluent in English\n* High blood pressure that is not under control\n* Having experienced a heart attack within the past 2 weeks\n* Pregnant of planning to become pregnant within the next six months","ALL","18 Years",{"count":20,"type":21},300,"ESTIMATED","INTERVENTIONAL",[24],"PHASE2","The present study aims to investigate the efficacy of an mHealth smoking cessation and HIV disease management intervention among a nationally representative sample of African America\u002FBlack (hereafter refer to as Black) persons with HIV\u002FAIDS (PWH) who smoke cigarettes. Participants will be randomized into one of three conditions: (1) the intervention, ESCAPE (Enhancing Smoking Cessation for African American People Everywhere) + Nicotine Replacement Medications (NRT), (2) the National Cancer Institute's (NCI) quitSTART app, the standard mobile smoking cessation treatment + NRT, and (3) an assessment-only control group + NRT.",[27,28,29],"ESCAPE Intervention+NRT","quitSTART Intervention+NRT","CTRL+NRT",[31,32,33,34,35,36,37,38],"HIV","Anxiety Sensitivity","Mobile Health","Smoking","Smoking Cessation","African American","Ecological Momentary Assessments","Just-in-Time Adaptive Intervention","RECRUITING","2026-07-10",{"date":42,"type":43},"2026-07-13","ACTUAL",{"date":45,"type":43},"2026-06-30",{"date":47,"type":21},"2029-06-30",{"name":49,"class":50},"University of Houston","OTHER",1,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":60,"sex":17,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":67,"conditions":68,"keywords":71,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":51},"100633790","early-phase-1-neuro-intermuscular-coordination-enhancement-nice-rehabilitation-through-human-machine-interaction-in-chronic-stroke-100633790","NCT07531264","Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation Through Human-Machine Interaction in Chronic Stroke","Neuro-Intermuscular Coordination Enhancement (NICE) Rehabilitation","NICE","Inclusion criteria for individuals after stroke are:\n\n* Hemiparetic chronic stroke survivors more than 6 months after stroke onset\n* Adults aged 21-80 years, including both female and male participants\n* Individuals with a single unilateral ischemic or hemorrhagic stroke\n* Individuals with Upper Extremity Fugl-Meyer Assessment score between 10 and 59 out of 66\n* Individuals who have not received botulinum toxin injections in the upper extremity within the past 3 months\n* Individuals without severe spasticity, defined as Modified Ashworth Scale score ≤3 at the elbow and shoulder\n\nExclusion criteria for individuals after stroke are:\n\n* Individuals younger than 21 years of age or older than 80 years of age\n* Individuals with an orthopedic disorder involving the upper limbs\n* Individuals unable to produce voluntary upper-extremity muscle EMG activity;\n* Individuals with cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol, assessed using the Montreal Cognitive Assessment or other IRB-approved screening procedures.\n* Individuals whose stroke-affected arm has an intermuscular coordination pattern similarity score \\>0.80 relative to the non-affected arm\n\nInclusion criteria for healthy individuals are:\n\n* Healthy adults aged 21-80 years, including both female and male participants\n* Individuals with no known neurological or orthopedic injuries\n\nExclusion criteria for healthy individuals are:\n\n* Individuals younger than 21 years of age or older than 80 years of age\n* Individuals with known neurological disorders\n* Individuals with orthopedic injuries or conditions affecting upper-extremity movement\n* Individuals unable to provide informed consent",true,"21 Years","80 Years",{"count":64,"type":21},48,[66],"EARLY_PHASE1","The objective of this study is to develop Neuro-Intermuscular Coordination Enhancement (NICE) rehabilitation, a novel neuromuscular control signal-guided strategy that visually guides stroke patients to individually activate motor modules through human-machine interaction. Ultimately, the development will lead to better clinical motor recovery, better quality of life, and lowered healthcare costs associated with the impairment.",[69,70],"Chronic Stroke-related Upper-extremity Motor Impairment","Motor Module-guided Rehabilitation Targeting Impaired Intermuscular Coordination and Motor Recovery",[72,73,74,75,76],"Muscle Synergy","Non-invasive Rehabilitation","Intermuscular Coordination","Stroke","Motor module","NOT_YET_RECRUITING","2026-06-15",{"date":80,"type":43},"2026-06-18",{"date":82,"type":21},"2027-08",{"date":84,"type":21},"2032-08",{"name":49,"class":50},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":60,"sex":94,"minAge":18,"maxAge":95,"enrollmentInfo":96,"targetDuration":4,"studyType":22,"phases":98,"briefSummary":100,"conditions":101,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":51},"100640820","phase-1-hormones-outcomes-and-pain-pathways-in-exercise-study-100640820","NCT07579182","Hormones, Outcomes, and Pain Pathways in Exercise Study","Mechanical and Non-mechanical Contributions to Chronic Neck, Shoulder, Arm, and Back Pain in Full-busted Women","HOPE","Inclusion Criteria:\n\n1. Able to provide informed consent\n2. Age of 18 to 60 years\n3. Assigned female sex at birth\n4. Right-handed by self-declaration\n5. Willing to participate in one online testing session and up to four in-person testing sessions\n6. Bra band size between 32-40\"\n7. International Physical Activity Questionnaire - Short Form (IPAQ-SF) score of 2 or higher\n8. An answer of \"NO\" to any item of the general health questions of the PARQ+\n9. No history of surgery to the: back, neck, or shoulders or joint replacement\n10. No history of implanted pacemakers or other stimulation devices\n11. No history of spinal cord injury (SCI)\n\nExclusion Criteria:\n\n1. Inability to provide informed consent\n2. Age 17 years old or younger or 61 years or older\n3. Assigned male sex at birth\n4. Left-handed by self-declaration\n5. Not willing to participate in one online testing session and up to four in-person testing sessions\n6. Bra band size greater than 40\" or less than 32\"\n7. IPAQ-SF score of 1 or lower\n8. An answer of \"YES\" to any item of the general health questions of the PARQ+\n9. History of limb amputation (upper or lower extremity)\n10. Presence of open pressure sores on the upper or lower extremities\n11. Currently pregnant or lactating\u002Fbreastfeeding\n12. History of surgery to the: back, neck, or shoulders or joint replacement\n13. History of breast cancer and\u002For mastectomy\n14. History of implanted pacemakers or other stimulation devices\n15. History of spinal cord injury (SCI)\n16. History of joint disease including osteoarthritis and\u002For Rheumatoid Arthritis\n17. History of the following neurological diseases: Cerebrovascular accident (CVA, stroke), Alzheimer's Disease (AD), Dementia (of any form), Huntington's Disease, Traumatic Brain Injury (TBI), Spinal cord injury (SCI), Multiple Sclerosis (MS), Parkinson's Disease (PD), Polio, Paraproteinaemic Demyelinating Neuropathy (PDN) and\u002For Monoclonal Gammopathy of Undetermined Significance (MGUS), Myasthenia Gravis, Muscular Dystrophy, Guillain-Barré Syndrome, Scoliosis, Charcot-Marie-Tooth Disorder or other hereditary neuropathies\n\nAdditional Inclusion Criteria for Intervention Group:\n\na. Self-declared breast size of D-I cup (US sizes: D, E, F, G, H)\n\nAdditional Inclusion Criteria for the Control Group:\n\na. Self-declared breast size of A-C cup (US sizes: AA, A, B, C)","FEMALE","60 Years",{"count":97,"type":21},140,[99],"PHASE1","The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the contribution of non-mechanical pathways associated with this type of pain in women. Specifically, the investigators will investigate how sex-hormones, inflammation, and remapping of specific regions of the brain contribute to the manifestation of neck, shoulder, arm, and back pain in full-busted women across the lifespan.",[102,103,104,105,106,107,108,109,110,111,112,113,114],"Breast Pain","Mastalgia","Back Pain","Back Pain, Low","Neck Pain","Chest Pain","Activity, Motor","Healthy Aging","Weight, Body","Inflammation","Gonadal Steroid Hormones","Neuronal Plasticity","Neuromuscular Manifestations","2026-05-28",{"date":117,"type":43},"2026-06-02",{"date":119,"type":43},"2026-05-17",{"date":121,"type":21},"2029-09",{"name":49,"class":50},{"id":124,"slug":4,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":22,"phases":126,"briefSummary":25,"conditions":127,"keywords":128,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":129,"lastUpdatePostDateStruct":130,"startDateStruct":132,"completionDateStruct":134,"leadSponsor":135,"locationsCount":51},"100594864",{"count":20,"type":21},[24],[27,28,29],[31,32,33,34,35,36,37,38],"2026-05-19",{"date":131,"type":43},"2026-05-20",{"date":133,"type":21},"2026-06-01",{"date":47,"type":21},{"name":49,"class":50},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":22,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":51},"100593496","early-phase-1-smart-olfaction-app-to-reduce-relapse-100593496","NCT07007195","Smart Olfaction App to Reduce Relapse","An Innovative Digitally-Delivered Olfactory Method for Reducing Cigarette Cravings and Supporting Smoking Cessation","SOARR","Inclusion Criteria:\n\n* At least 18 years of age\n* Ability to read, understand and speak English\n* Currently smoke at least 5 cigarettes daily for one year or longer\n* Do not currently smoke marijuana or currently smoke marijuana but willing to not smoke during the duration of the study\n* Did not use electronic cigarette or vaping device in the past 90 days\n* Have an active smartphone that is Apple or Android based\n* Have phone service including a data plan\n* Interested in downloading the study app onto their personal phone\n* Motivated to quit smoking\n* English literacy of 7th grade or higher, as indicated by a score of ≥ 4 on the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-SF)\n* Biochemical verification of smoking status\n* Proof of smoking status at enrollment via photo of cigarettes\n* Presents a photo ID that matches the information on screener survey\n* Willing and able to complete study procedures\n* Willing to use NRT and quit smoking for 14 days (Phase I) or willing to use NRT and quit smoking for 13 weeks (Phase II)\n\nExclusion Criteria:\n\n* Olfactory dysfunction including inability to smell, a very weak or distorted sense of smell, or sensitivity to odors\n* Report any allergies or negative reactions to odors\u002Ffragranced products\n* Being pregnant, breastfeeding, or planning to become pregnant within the next month\n* Report hypertension that is not under control\n* Have had a heart attack within the past two weeks\n* Those who participated in Phase I will not be eligible to participate in Phase II\n* Have a smartphone that is not compatible with the Insight mHealth platform\n* Report using electronic cigarette or vaping device in the past 90 days\n* Cognitive impairment, verified via a score of ≥ 8 on the Six-Item Cognitive Impairment Test (6-CIT)",{"count":145,"type":21},132,[66],"The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based smoking cessation application. The specific aims of this study are: (1) refine the design and methodology of our olfactory stimulation delivery system (OSDS) and (2) compare, in a pilot randomized controlled trial (RCT), the effects of a smartphone based app for smoking cessation (Smart-T) with and without the OSDS on smoking cessation outcomes.",[149],"Nicotine Dependence",[151,35,152,149],"Substance-Related Disorders","Smartphone-Based Smoking Cessation","2026-04-29",{"date":155,"type":43},"2026-05-01",{"date":157,"type":43},"2026-04-22",{"date":159,"type":21},"2027-08-31",{"name":49,"class":50},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":60,"sex":17,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":172,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":51},"100586703","reducing-obesity-through-play-among-toddlers-tiny-steps-to-health-tshs-study-100586703","NCT06918821","Reducing Obesity Through Play Among Toddlers: Tiny Steps to Health (TSHS) Study","Reducing Obesity Through Play: A Randomized Control Trial","TSHS","Inclusion criteria:\n\n* Parents: Primary custodian (i.e., legal guardian) of a toddler, \\>18 years, have regular and frequent access to internet, fluent in English.\n* Toddlers: \\>\u002F=18 and \\\u003C\u002F=36 months of age, and walking.\n\nExclusion criteria include:\n\n* Parents or toddlers who have mental or physical conditions that would prevent engagement in nutrition, physical activity, play, or instructional activities in a group setting or families unwilling to commit to the whole program (e.g., planning to move) will be excluded because participants may be randomly assigned to group interventions where engagement in these activities will be expected.\n\n  * Parents who are not fluent in English will be excluded because this study was developed, and pilot tested on an English-speaking population. All study materials are in English, the interventions will be offered in English, and most of the surveys are not available or have been validated for non-English speaking audiences.\n  * Parents who are not willing or able to participate in parent-toddler interaction assessments via Zoom will be excluded. This assessment is an important study variable.\n* Parents who are not willing to be recorded will be excluded because all Families Understanding Nutrition and Physically Active LIfestyles (FUNPALs) Playgroup sessions will be recorded for facilitator supervision purposes, and the parent-toddler interaction assessments will be recorded for later coding.\n* Only one toddler and one parent per family will be eligible, but all children and siblings within a household will be able to attend playgroups or childcare while parents are in Healthy Toddler Parent Group (HTPG) classes.\n* Parents and toddlers who received 1 or more sessions of the FUNPALs Playgroup or the HTPG. This study will be running 1 cohort per quarter for 4 years, so it is possible that families may drop out and want to re-enroll in a later cohort or enroll when younger siblings are eligible. They will not be eligible. Also, families from the community will be invited to participate in practice sessions of FUNPALs or HTPG to train the facilitators. These families will not be eligible to participate in the study.","18 Months","36 Months",{"count":20,"type":21},[173],"NA","The purpose of this study is to test various ways to help toddlers develop healthy eating and activity behaviors. Parents and toddlers, who participate in this research will be randomly assigned to either 1) continue their lifestyle behaviors for 10-weeks and then receive a health club membership for 1-month, 2) attend a health promotion playgroup together for 10 weeks, or 3) to attend an educational class for parents while toddlers are in childcare for 10-weeks. Physical measures of toddlers (height, weight, dietary intake, activity) will be collected. Parent-report surveys with questions about parenting, toddler diet, toddler temperament, food security status, demographic qualities, and satisfaction with group assignment will be collected. Last, the interactions between parents and toddlers will be observed and assessed during short play tasks via Zoom. All measures will be collected immediately upon signing up for the study (week 0), 10-weeks later (post), and 24-weeks after signing up for the study.",[176],"Childhood Obesity",[178,179,180,181],"toddlers","diet","physical activity","parenting",{"date":183,"type":43},"2026-05-05",{"date":185,"type":43},"2025-05-17",{"date":187,"type":21},"2029-02-28",{"name":49,"class":50},{"id":190,"slug":191,"hasResults":11,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":58,"eligibilityCriteria":195,"healthyVolunteers":60,"sex":17,"minAge":196,"maxAge":197,"enrollmentInfo":198,"targetDuration":4,"studyType":22,"phases":200,"briefSummary":201,"conditions":202,"keywords":203,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":207,"lastUpdatePostDateStruct":208,"startDateStruct":210,"completionDateStruct":212,"leadSponsor":214,"locationsCount":51},"100556302","increasing-the-repertoire-of-intermuscular-co-ordination-post-stroke-through-emg-guided-human-machine-interaction-100556302","NCT06523335","Increasing the Repertoire of Intermuscular Co-ordination Post Stroke Through EMG-Guided Human-Machine Interaction","Intermuscular Coordination as a Novel Clinical Target for Stroke Neurorehabilitation","Inclusion criteria for aged matched healthy group\n\n* Male or female whose age range between 40 and 75\n* no known neurological injuries\n\nExclusion criteria for aged matched healthy group\n\n* have an orthopedic disorder involving upper limbs;\n* have a history of any neurologic disease;\n* have any history of epilepsy of the potential participants and\u002For their family members;\n* are unable to consent;\n* are pregnant.\n\nInclusion criteria for stroke group\n\n* male or female hemiparetic chronic stroke survivors;\n* age ranging between 40-75 year;\n* with single unilateral ischemic or hemorrhagic middle cerebral artery stroke;\n* neurologically stable for \\>6 months;\n* have an expectation that current medication will be maintained without changes for at least 3 months. Stable use of anti-spasticity medication (e.g., baclofen, diazepam, tizanidine) is accepted;\n* without severe spasticity (Modified Ashworth (MA) \\\u003C4);\n* have not received botulinum toxin on the impaired arm within 3 months.\n\nExclusion criteria for stroke group\n\n* have an orthopedic disorder involving upper limbs;\n* cognitive impairment sufficient to interfere with informed consent or successful completion of the protocol (Montreal Cognitive Assessment (MoCA) score \\\u003C 26);\n* a history of another neurologic disease;\n* anesthesia of joint position sense in upper limbs;\n* are pregnant or have a chance that they might be (self-reported);","40 Years","75 Years",{"count":199,"type":21},74,[173],"The purposes of this study include:\n\n1. \\- To identify whether features of aberrant intermuscular coordination patterns can be used to predict motor impairment after stroke.\n2. \\- To test whether muscle synergies are malleable to a non-invasive EMG-guided exercise that induces changes in intermuscular coordination of upper extremity muscles after stroke.",[75],[204,74,205,206,75],"Muscle synergy","Electromyogram-guided exercise","Motor neurorehabilitation","2026-04-28",{"date":209,"type":43},"2026-05-04",{"date":211,"type":43},"2024-10-01",{"date":213,"type":21},"2029-09-01",{"name":49,"class":50},{"id":216,"slug":217,"hasResults":11,"nctId":218,"briefTitle":219,"officialTitle":220,"acronym":221,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":223,"targetDuration":4,"studyType":22,"phases":224,"briefSummary":225,"conditions":226,"keywords":230,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":237,"completionDateStruct":239,"leadSponsor":241,"locationsCount":51},"100594924","shaping-habitual-impulses-for-a-tobacco-free-style-100594924","NCT07025772","Shaping Habitual Impulses For a Tobacco-free Style","Approach Bias Retraining to Augment Long-Term Smoking Cessation Among a Diverse Sample","SHIFTS","Inclusion Criteria:\n\n* At least 18 years of age\n* Ability to speak English fluently\n* Ability to read English fluently\n* Ability to write in English fluently\n* Biochemical verification of self-reported smoking status following minimum study specified smoking rate endorsement\n* Motivated to quit smoking\n* Willing to attend in-person visits\n* Provide written informed consent, accepting study inclusion criteria and the randomized group assignment\n* English literacy of 7th grade or higher, as indicated by a score of 4 or greater on the Rapid Estimate of Adult Literacy in Medicine-Short Form (REALM-SF)\n\nExclusion Criteria:\n\n* Having used an e-cigarette in the past 3 months\n* Having initiated any mental health therapy or pharmacotherapy within the past 3 months\n* Being currently in therapy for substance abuse (including nicotine dependence)\n* Being currently enrolled in any other studies at the RESTORE lab to help quit smoking\n* Currently using any NRT or psychotherapy products for nicotine cessation\n* Currently using Bupropion as a smoking cessation aid and antidepressant\n* Currently pregnant or planning to become pregnant\n* Having high blood pressure that is not under control\n* Having a heart attack within the past 2 weeks\n* Having Visual impairments\n* Hand-motoric impairments\n* Currently suicidal or high suicide risk or current or past psychotic disorders of any type, bipolar disorder, schizophrenia or schizoaffective disorder, anorexia, bulimia assessed using the Mini Neuropsychiatric Interview\n* Cognitive impairment, verified via a score of ≥8 on the Six-Item Cognitive Impairment Test (6-CIT)",{"count":20,"type":21},[173],"The present investigation aims to assess the efficacy of an innovative and novel smoking cessation intervention that integrates approach bias retraining (ABR) and standard smoking cessation treatment (ST). Participants will be randomized to either: (1) standard smoking cessation treatment and approach bias retraining (ST+ABR); (2) ST+Sham; or (3) ST-only.",[227,228,229],"ST+ABR","ST+SHAM","ST-only",[231,232,233],"Approach bias retraining","smoking cessation","cognitive retraining","2026-04-15",{"date":236,"type":43},"2026-04-17",{"date":238,"type":43},"2026-03-24",{"date":240,"type":21},"2029-02-01",{"name":49,"class":50},{"id":243,"slug":244,"hasResults":11,"nctId":245,"briefTitle":246,"officialTitle":246,"acronym":4,"eligibilityCriteria":247,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":248,"targetDuration":4,"studyType":22,"phases":250,"briefSummary":251,"conditions":252,"keywords":255,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":51},"100606282","low-level-light-therapy--skin-pigmentation-100606282","NCT07173530","Low Level Light Therapy & Skin Pigmentation","Inclusion Criteria:\n\n* Ability to read and understand the study informed consent in English\n* Age 18 years or older at enrollment\n* Individuals with MGD based on one or more of the following clinical signs\u002Fsymptoms, e.g., meibum quality score of 1-3 (Bron et al.), meibography score of 1, 2, or 3 on the Pult Meiboscale, non-invasive 1st tear break up time of 10 seconds or less, or an Ocular Surface Disease Index (OSDI) score greater than 12 points.\n\nExclusion Criteria:\n\n* Active anterior segment pathology (e.g., bacterial conjunctivitis, microbial keratitis)\n* History of systemic disease associated with aqueous-deficient dry eye disease (e.g., Sjogren's syndrome)\n* History of corneal surgery, refractive surgery, or eyelid surgery within 6 months\n* History of corneal ectasia (e.g. keratoconus, Pellucid marginal degeneration)\n* History of ocular trauma within 6 months\n* History of LipiFlow, iLux, Meiboflow, IPL or LLLT within the last 12 months\n* Habitual use of photosensitizing medications within the last 30 days\n* Pregnant and\u002For lactating females, by self-report\n* Pigmented lesions, tattoos, or skin cancer in the periocular region\n* Unwilling to have eyes photographed or video recorded",{"count":249,"type":21},40,[173],"The goal of this clinical trial is to determine if there is a difference in eyelid temperature after low-level light therapy (LLLT) in individuals with different amounts of skin pigmentation and dry eye\u002Fmeibomian gland disease. Participants will have 3 fifteen minute in office LLLT therapy sessions over a period of approximately 7 to 14 days.",[253,254],"Dry Eye","Meibomian Gland Dysfunction (Disorder)",[253,256,257,258],"Meibomian Gland","LLLT","Low-level light therapy","2025-09-08",{"date":261,"type":43},"2025-09-15",{"date":263,"type":43},"2025-06-11",{"date":265,"type":21},"2026-08",{"name":49,"class":50},{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":4,"eligibilityCriteria":273,"healthyVolunteers":60,"sex":17,"minAge":274,"maxAge":275,"enrollmentInfo":276,"targetDuration":4,"studyType":22,"phases":277,"briefSummary":278,"conditions":279,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":51},"100582662","emergent-bilinguals-child-language-proficiency-and-language-of-treatment-100582662","NCT06866223","Emergent Bilinguals: Child Language Proficiency and Language of Treatment","Emergent Bilinguals: the Relationship Between Child Language Proficiency and Language of Treatment on the Outcomes Children with Developmental Language Disorder","Inclusion Criteria:\n\n1. parent concerns and\u002For a history of receiving services in the public schools\n2. age-specific cutoffs for the morphosyntax subtests for their best language (English or Spanish) on the Bilingual English Spanish Assessment. The cut-off score for best language for 4-year-olds is 84, for 5-year-olds is 85, and for 6-year-olds is 81.\n\n   Using the best-language approach, these scores have a sensitivity over 90% and specificity over 80% for children between 4;0 and 6;11 years of age , which is considered acceptable for studies of diagnostic accuracy.\n3. nonverbal IQ, as measured by the Kaufman Brief Intelligence Test-2, matrices subtest, will be at or above a standard score of 70.\n4. pass a hearing screening test\n5. participants must be emergent bilingual, that is children must be producing at least simple sentences in spontaneous speech in either Spanish or English and be exposed to both langauges\n6. participants must be able to benefit from treatment for both conditional adverbial clauses and complement clauses, as evidenced by accuracy below 40% on 10-item elicited production probes in both languages\n\nExclusion Criteria:\n\n1\\) children with significant sensory-motor concerns or psychiatric disorders per parent report will not be enrolled.","4 Years","6 Years",{"count":249,"type":21},[173],"Of the 12 million children in the USA growing up bilingual, about 1 million experience Developmental Language Disorder (DLD), a disorder in language learning and use. Currently there is no guidance for speech language pathologists (SLPs) as to the language of intervention for emergent Spanish-English bilingual children with DLD. This project will examine the relationship between language proficiency and the language of intervention, considering monolingual intervention (Spanish or English) and interleaved Spanish-English intervention with the goal of improving language outcomes and thereby strengthening long-term academic achievement",[280,281],"Developmental Language Disorder","Language Impairment","2025-03-04",{"date":284,"type":43},"2025-03-10",{"date":286,"type":43},"2024-11-11",{"date":288,"type":21},"2028-07-01",{"name":49,"class":50},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":60,"sex":17,"minAge":274,"maxAge":275,"enrollmentInfo":296,"targetDuration":4,"studyType":22,"phases":298,"briefSummary":299,"conditions":300,"keywords":301,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":51},"100522644","the-relationship-between-child-language-proficiency-and-language-of-treatment-on-the-outcomes-of-bilingual-children-with-developmental-language-disorder-100522644","NCT06085300","The Relationship Between Child Language Proficiency and Language of Treatment on the Outcomes of Bilingual Children with Developmental Language Disorder","Inclusion Criteria:\n\n1. parent concerns and\u002For a history of receiving services in the public schools\n2. age-specific cutoffs for the morphosyntax subtests for their best language (English or Spanish) on the Bilingual English Spanish Assessment. The cut-off score for best language for 4-year-olds is 84, for 5-year-olds is 85, and for 6-year-olds is 81. Using the best-language approach, these scores have a sensitivity over 90% and specificity over 80% for children between 4;0 and 6;11 years of age , which is considered acceptable for studies of diagnostic accuracy.\n3. nonverbal IQ, as measured by the Kaufman Brief Intelligence Test-2, matrices subtest, will be at or above a standard score of 70.\n4. pass a hearing screening test\n5. participants must be bilingual, that is children must be producing at least simple sentences in spontaneous speech in both Spanish and English, or understand English and Spanish.\n6. participants must be able to benefit from treatment for both conditional adverbial clauses and complement clauses, as evidenced by accuracy below 40% on 10-item elicited production probes in both languages\n\nExclusion Criteria:\n\n* 1\\) children with significant sensory-motor concerns or psychiatric disorders per parent report will not be enrolled.",{"count":297,"type":21},120,[173],"Of the 12 million children in the USA growing up bilingual, about 1 million experience Developmental Language Disorder (DLD), a disorder in language learning and use. Currently there is no guidance for speech language pathologists (SLPs) as to the language of intervention for bilingual children with DLD with differing degrees of proficiency with English or Spanish. This project will examine the relationship between relative language proficiency and the language of intervention, considering monolingual intervention in English and Spanish and bilingual intervention presented by alternating English and Spanish treatment sessions with the goal of improving language outcomes and thereby strengthening long-term academic achievement.",[280,281],[302,303,304,305,306],"developmental language disorder","bilingual children","sentence recast","Bilingual proficiency","Language transfer","2025-01-12",{"date":309,"type":43},"2025-01-14",{"date":311,"type":43},"2023-08-08",{"date":313,"type":21},"2028-05-01",{"name":49,"class":50},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":60,"sex":17,"minAge":322,"maxAge":323,"enrollmentInfo":324,"targetDuration":4,"studyType":22,"phases":325,"briefSummary":326,"conditions":327,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":331,"startDateStruct":333,"completionDateStruct":335,"leadSponsor":337,"locationsCount":51},"100512144","misc-ipv-a-community-based-intervention-for-children-traumatized-by-intimate-partner-violence-100512144","NCT05948631","MISC-IPV: a Community-Based Intervention for Children Traumatized by Intimate Partner Violence","MISC-IPV","Mother inclusion criteria:\n\n1. Enrolled in Harris County Domestic Violence rehousing program\n2. Fluency in English\n\nMother exclusion criteria:\n\n1. Active suicidality\n2. Intellectual disability\n3. Active psychotic disorder\n\nChild inclusion criteria:\n\n1. Exposure to domestic violence\n2. 7-11 years old in a family\n\nChild exclusion criteria:\n\n1. Intelligence quotient below 75,\n2. Active psychosis\n3. Severe autism\n4. Below age 7 or above age 11","7 Years","65 Years",{"count":145,"type":21},[173],"This study adapts and evaluates preliminary outcomes of the Mediational Intervention for Sensitizing Caregivers (MISC) for women and children of color who have survived domestic violence.",[328,329],"MISC Intervention","Treatment As Usual","2024-12-04",{"date":332,"type":43},"2024-12-09",{"date":334,"type":43},"2023-02-14",{"date":336,"type":21},"2025-04-30",{"name":49,"class":50},{"id":339,"slug":340,"hasResults":11,"nctId":341,"briefTitle":342,"officialTitle":343,"acronym":4,"eligibilityCriteria":344,"healthyVolunteers":60,"sex":17,"minAge":322,"maxAge":345,"enrollmentInfo":346,"targetDuration":4,"studyType":22,"phases":348,"briefSummary":349,"conditions":350,"keywords":352,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":330,"lastUpdatePostDateStruct":357,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":51},"100511722","misc-cbo-to-improve-the-mental-health-of-ovc-in-south-africa-100511722","NCT05943132","MISC-CBO to Improve the Mental Health of OVC in South Africa","MISC-CBO: a Cluster Randomized Control Trial to Improve the Mental Health of OVC in South Africa","Inclusion Criteria:\n\n1. Status as OVC.\n2. Children will be 7-11 years old\n3. Resident in the CBO catchment area\n4. Child has a legal guardian\n\nExclusion Criteria:\n\n1. Children with a medical history of serious birth complications\n2. Children with a medical history severe malnutrition\n3. Children with a neurological disability","11 Years",{"count":347,"type":21},792,[173],"The goal of this cluster randomized control clinical trial is to evaluate the effectiveness of the Mediational Intervention for Sensitizing Caregivers for Community-based Organizations (MISC-CBO) in reducing mental health problems in orphan and vulnerable children in South Africa.\n\nAim 1 will evaluate the direct effects of MISC-CBO on video-coded CBO caseworker caregiving quality (affiliation and attachment) and children's mental health outcomes over a 24 month period. 24 CBOs (360 children and 72 caseworkers) will be recruited using existing Non-Governmental Organization (NGO) partner (Childline) in two districts in the Free State, South Africa (SA). CBOs will be randomly assigned to receive either one year of bi-weekly MISC-CBO or Treatment as Usual (TAU). The investigators hypothesize that MISC-CBO will be associated with comparative increases in caseworker caregiving quality and reductions in mental health problems in Orphans and Vulnerable Children (OVC).\n\nAim 2a,will test the hypothesis that caregiving quality at end-of-intervention (12 months) accounts for intervention effects on child mental health at 18 and 24 months. Aim 2b will evaluate the moderating effects of orphan status and the quality of the home environment, expecting that OVC who are maternal and double orphans, and from impoverished home environments will show reduced response to intervention compared to children without these risk factors.\n\nAim 3a will use World Health Organization metrics to test the hypothesis that MISC-CBO is cost-effective in terms of disability-adjusted life years (DALYs) averted. Aim 3b will use qualitative methodology to test the hypothesis that community stakeholders deem the climate favorable and ready for the implementation of MISC-CBO, and that additional barriers and facilitators for scale-up and implementation will be identified.\n\nThe proposed work extends the investigators' formative work to now fully test the real-world effectiveness, mechanisms of action, cost-effectiveness and implementation readiness of MISC-CBO during the critical developmental window of at-risk children aging into adolescence, consistent with National Institute of Mental Health's strategic objectives.",[351],"Mental Disorder, Child",[353,354,355,356],"mental health problems","Mediational Intervention for Sensitizing Caregivers","mentalizing","caregivers",{"date":332,"type":43},{"date":359,"type":43},"2023-06-12",{"date":361,"type":21},"2026-07-01",{"name":49,"class":50},{"id":364,"slug":365,"hasResults":11,"nctId":366,"briefTitle":367,"officialTitle":368,"acronym":369,"eligibilityCriteria":370,"healthyVolunteers":60,"sex":17,"minAge":18,"maxAge":197,"enrollmentInfo":371,"targetDuration":4,"studyType":22,"phases":373,"briefSummary":374,"conditions":375,"keywords":377,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":382,"lastUpdatePostDateStruct":383,"startDateStruct":385,"completionDateStruct":387,"leadSponsor":389,"locationsCount":390},"100217940","human-machine-system-for-the-h2-lower-limb-exoskeleton-100217940","NCT02114450","Human-Machine System for the H2 Lower Limb Exoskeleton","Human Machine Interface System With the H2 Lower Limb Exoskeleton for Rehabilitation","H2-NeuroExo","Inclusion Criteria:\n\n* Sub-acute or chronic stroke i.e., interval of at least 3 months or interval of at least 6 months from stroke to time of enrollment, respectively;\n* Cognitive ability to assimilate and participate actively in the treatment protocol (Mini Mental State Examination score \\> 24 points, out of a total 30 indicating normal cognitive ability);\n* Modified Rankin scale scores 2-4 (Mild-Moderate functional disability post-stroke);\n* Modified Ashworth Scale of Spasticity score \\\u003C= 2 (ranges from 0-4 with 4 reflecting maximum spasticity);\n* Have no skin integrity issues;\n* Sufficient passive range of motion at the hip (at least 90 deg flexion, 15-20 deg extension), knee (90 deg flexion, complete extension) and ankle (15 deg dorsiflexion, 15 deg plantarflexion);\n* Have no contraindications to standing or walking; able to stand with assistive device for at least 5 minutes, and able to walk with assistive device for 10 m.\n\nExclusion Criteria:\n\n* Severe cognitive and\u002For visual deficit;\n* Hemineglect (determined based on medical record or initial clinical assessment);\n* Severe sensory deficit;\n* Joint contractures of any extremity that limits normal range of motion during ambulation with assistive devices;\n* Skin lesions that may hinder or prevent the application of exoskeleton;\n* Uncontrolled angina;\n* Severe chronic obstructive pulmonary disease;\n* Other medical contraindications; any medical co-morbidities that would prevent standard rehabilitation.\n\nInclusion criteria for healthy, able-bodied participants:\n\n* Able to understand and sign the consent form\n* Age 18-75 years\n\nExclusion criteria for healthy, able-bodied participants:\n\n\\- History of neurological, neuromuscular or physical disability.",{"count":372,"type":21},60,[173],"This research study will investigate the use of smart lower limb robotic exoskeleton (developed by the CSIC, Spain) in rehabilitation after stroke. It will compare robotic-assisted rehabilitation with supervised motor practice. Additionally, it will also examine the use of noninvasive scalp electroencephalography (EEG) to learn specific brain wave patterns associated with learning to walk on the powered lower limb exoskeleton. The findings will be used to understand human-robot interaction and to design smart orthotic devices that can be controlled by thought activity and assist those that have lost all or part of their walking abilities.",[75,376],"Hemiparesis",[75,378,379,380,381],"Paresis","Gait rehabilitation","Human-Machine Interaction","Wearable Robotic Devices","2024-10-26",{"date":384,"type":43},"2024-10-30",{"date":386,"type":43},"2015-11-20",{"date":388,"type":21},"2029-12",{"name":49,"class":50},2,{"id":392,"slug":393,"hasResults":11,"nctId":394,"briefTitle":395,"officialTitle":396,"acronym":4,"eligibilityCriteria":397,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":398,"targetDuration":4,"studyType":22,"phases":400,"briefSummary":401,"conditions":402,"keywords":403,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":406,"lastUpdatePostDateStruct":407,"startDateStruct":409,"completionDateStruct":411,"leadSponsor":413,"locationsCount":4},"100561121","mobile-smoking-treatment-for-hispanic-individuals-who-smoke-100561121","NCT06586034","Mobile Smoking Treatment for Hispanic Individuals Who Smoke","Culturally-Adapted Smoking Cessation Mobile App for Hispanic Individuals Who Smoke","Inclusion Criteria:\n\n* 1\\) being Hispanic, 2) at least 18 years of age, 2) currently smoking (i.e., at least 5 cigarettes\u002Fday) biochemically verified by a CO \\> 7, 3), meeting criteria for high AS (cut-off score of 5 on the Short Scale Anxiety Sensitivity Index), 4) motivation to quit \\> 5 on a 10 pt. scale, 5) able to provide informed consent, 6) has daily access to their own iPhone or Android smartphone, and 7) is a fluent English or Spanish speaker.\n\nExclusion Criteria:\n\n* 1\\) current participation in substance abuse treatment, 2) in psychotherapy for anxiety or depression, 3) concurrent use of medication for anxiety or depression, 4) active suicidality (ideation, intent, and\u002For plan), or 5) current psychosis.",{"count":399,"type":21},56,[173],"The specific aims of the project are to develop and test a mobile application for smoking cessation for Hispanic individuals who smoke called Impacto.",[35],[404,35,405],"Mobile App","Hispanic\u002FLatino","2024-09-03",{"date":408,"type":43},"2024-09-19",{"date":410,"type":21},"2025-04",{"date":412,"type":21},"2026-03",{"name":49,"class":50},{"id":415,"slug":416,"hasResults":11,"nctId":417,"briefTitle":418,"officialTitle":419,"acronym":4,"eligibilityCriteria":420,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":4,"enrollmentInfo":421,"targetDuration":4,"studyType":22,"phases":423,"briefSummary":424,"conditions":425,"keywords":428,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":431,"lastUpdatePostDateStruct":432,"startDateStruct":434,"completionDateStruct":436,"leadSponsor":438,"locationsCount":51},"100548059","a-mobile-intervention-for-black-individuals-who-engage-in-hazardous-drinking-100548059","NCT06416059","A Mobile Intervention for Black Individuals Who Engage in Hazardous Drinking","A Mobile-Delivered Personalized Feedback Intervention for Black Individuals Who Engage in Hazardous Drinking","Inclusion Criteria:\n\n* Being 21 years of age or older\n* Self-identifying as Black or African American\n* Meeting criteria for current hazardous drinking pattern\n* Meeting criteria for clinical anxiety\n* Being able to provide written, informed consent\n* Owning a smartphone.\n\nExclusion Criteria:\n\n* Current participation in alcohol or other substance abuse treatment\n* Engaged in psychotherapy for anxiety or depression\n* Concurrent use of medication for anxiety or depression\n* Being pregnant by self-report\n* Residence outside of the United States confirmed via survey geolocation\n* Inability to provide a valid United States-issued driver's license or identification card to verify identity.",{"count":422,"type":21},50,[173],"The purpose of this study is to develop and examine a culturally adapted, mobile health application for the Android and iOS platform. The application uses a personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Black hazardous drinkers with clinical anxiety.",[426,427],"Alcohol Abuse","Anxiety",[36,429,430],"Black","Personalized Feedback Intervention","2024-06-12",{"date":433,"type":43},"2024-06-17",{"date":435,"type":43},"2023-05-15",{"date":437,"type":21},"2024-08-31",{"name":49,"class":50},{"id":440,"slug":441,"hasResults":11,"nctId":442,"briefTitle":443,"officialTitle":444,"acronym":4,"eligibilityCriteria":445,"healthyVolunteers":11,"sex":17,"minAge":61,"maxAge":197,"enrollmentInfo":446,"targetDuration":4,"studyType":22,"phases":448,"briefSummary":449,"conditions":450,"keywords":451,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":454,"lastUpdatePostDateStruct":455,"startDateStruct":457,"completionDateStruct":459,"leadSponsor":461,"locationsCount":51},"100458175","personalized-feedback-intervention-for-latinx-drinkers-with-anxiety-100458175","NCT05246202","Personalized Feedback Intervention for Latinx Drinkers With Anxiety","Latinx Hazardous Drinkers With Clinical Anxiety: Effectiveness Trial of a Personalized Normative Feedback Intervention","Inclusion Criteria:\n\n* Being between the age of 21 to 75 years of age\n* Being self-identified as Latinx or Hispanic\n* Fluent in Spanish\n* Meeting criteria for current hazardous drinking pattern\n* Meeting criteria for clinical anxiety\n* Being able to provide written, informed consent\n\nExclusion Criteria:\n\n* Being involved in alcohol or other substance use program\n* Currently pregnant\n* Current engagement in psychotherapy for anxiety",{"count":447,"type":21},250,[173],"The purpose of this study is to develop, evaluate the acceptability\u002Ffeasibility (Phase IA), and test (Phase IB) the effectiveness of a brief, integrated, single-session, computer-based, culturally adapted personalized feedback intervention (PFI) designed to enhance knowledge regarding adverse anxiety-alcohol interrelations, increase motivation and intention to reduce hazardous drinking, and reduce positive attitudes and intention regarding anxiety-related alcohol use among Latinx hazardous drinkers with anxiety.",[426,427],[452,453,430],"Latinx","Hispanic","2024-06-06",{"date":456,"type":43},"2024-06-07",{"date":458,"type":43},"2022-09-30",{"date":460,"type":21},"2026-05-31",{"name":49,"class":50},""]