[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Huelva\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":82},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100577334","early-phase-1-deprescription-of-antidepressants-in-primary-care-dapricare-100577334",false,"NCT06796946","Deprescription of Antidepressants in Primary Care (DAPriCare)","Intervention for Antidepressant Deprescription in Primary Care: a Randomized Community Clinical Trial","DAPriCare","Inclusion Criteria:\n\n* be of legal age (≥18 years),\n* have received at least one antidepressant prescription in the year before the start of the study,\n* and have the physical capacity to go to the health center and the mental capacity to give informed consent\n\nExclusion Criteria:\n\n* minors,\n* have changed health centers,\n* have physical or mental disabilities (including advanced dementia, severe cognitive deficit, advanced Alzheimer's disease, and disability \\>70%), or,\n* are hospitalized at the time of selection",true,"ALL","18 Years",{"count":21,"type":22},325,"ESTIMATED","INTERVENTIONAL",[25],"EARLY_PHASE1","Introduction The consumption of antidepressants has increased considerably worldwide, including in Spain. Despite their effectiveness in cases of moderate to severe depression, their long-term use in mild cases is questioned. This study aims to evaluate the effectiveness of a deprescribing intervention in primary care, to reduce the unnecessary consumption of these drugs and improve patients' quality of life.\n\nMaterial and Methods A community-based clinical trial will be carried out before and after in an adult population of residents of an urban area of Cadiz (Spain) who have been prescribed antidepressants in the last year. Participants will be randomly selected and followed up for a predetermined period after consensus.\n\nThe intervention will consist of a comprehensive evaluation of antidepressant treatment by a team of health professionals. Factors such as indication, dose, and response to treatment will be evaluated, and the Hamilton scale for anxiety and the Beck Inventory for depression will be used. In those cases where it is considered appropriate, a gradual reduction or suspension of the drug will be proposed, always under medical supervision.\n\nConclusions This research will contribute to generating scientific evidence on the safety and efficacy of deprescribing in primary care, promoting a more rational use of antidepressants, and improving the quality of life of patients. The results obtained could have important implications for clinical practice and for the development of clinical practice guidelines.",[28,29],"Deprescription","Antidepressants",[31,32,33,34,35,36],"Deprescribing","antidepressants","primary care","clinical trials","mental health","adverse effects","NOT_YET_RECRUITING","2026-04-28",{"date":40,"type":41},"2026-05-04","ACTUAL",{"date":43,"type":22},"2026-06",{"date":45,"type":22},"2027-03",{"name":47,"class":48},"University of Huelva","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":18,"minAge":19,"maxAge":4,"enrollmentInfo":58,"targetDuration":60,"studyType":61,"phases":4,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":73,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":49},"100552254","ema-for-predicting-treatment-outcomes-in-patients-with-sud-100552254","NCT06470698","EMA for Predicting Treatment Outcomes in Patients With SUD","Neuropsychological Assessment in Real Time of the Implicit Cognition in the Prediction of Relapse of Patients With Substance Use Disorder","TEMPTATION","Inclusion Criteria:\n\n1. Patients initiating treatment for addiction to cocaine or alcohol as the primary substance.\n2. Patients with a diagnosis of Substance Use Disorder of mild, moderate, or severe severity, according to the 5th Edition of the DSM (Diagnostic and Statistical Manual of Mental Disorders).\n3. Maintaining residency in the province of Huelva during the study\\'s follow-up period.\n4. Willingness to participate in the study by providing informed consent.\n5. Possessing a mobile device that meets the necessary technical requirements for the installation and operation of the application.\n\nExclusion Criteria:\n\n1. Patients with severe, unstable mental disorders, as assessed by the clinical team at the treatment centers.\n2. Patients with physical or mental disorders that hinder the execution of the tests and assessments included in the study.\n3. Patients under the age of 18.\n4. Patients with opioid consumption.",{"count":59,"type":22},130,"1 Year","OBSERVATIONAL","This longitudinal repeated measures study will evaluate participants at the beginning of treatment through an assessment of psychological measures and craving. They will be trained to use a mobile platform, which will be available for 12 days. The assessment will be conducted via Ecological Momentary Assessment (EMA), with scheduled daily access and during situations of consumption risk. Each access will include questions on substance use, depression, anxiety, triggering situations, attitude towards drugs, and a cognitive bias test. The platform will alternate between two tests (Drug Stroop Task and WAT-DUD). Participants will follow a treatment program supervised by professionals.\n\nThe study aims to recruit 130 participants (65 for alcohol, 65 for cocaine) from the Provincial Service for Drug Dependence and Addictions in Huelva (SPDA). Participants, selected via stratified random sampling, must reside in Huelva, sign informed consent, have a compatible mobile device, and be over 18. Anonymity will be ensured through alphanumeric codes.\n\nUpon treatment admission, selected patients will be informed of their participation in the study. Interviews, conducted by psychologists, will outline the study objectives and duration. Patients agreeing to participate will sign informed consent and receive an identification code. Baseline assessment data will be integrated into a database for subsequent statistical analysis. The assessment encompasses the collection of four blocks of information:\n\nBlock 1. Patients medical history initiated during treatment admission. Block 2. Neuropsychological battery developed by the research team for the baseline evaluation.\n\nBlock 3. Neuropsychological battery developed by the research team for the web platform measured through Ecological Momentary Assessment (EMA).\n\nBlock 4. Follow-up information at three and six months provided by SPDA professionals through the patients medical history.\n\nTo ensure compliance with participant follow-up, a mixed monitoring protocol has been developed, which includes phone calls and WhatsApp messages. This protocol is designed according to social exchange theory so that participants perceive the benefits of their participation as outweighing the costs.\n\nThe statistical analysis involves identifying outliers and trimming distributions. Data will be averaged per test per person, considering different conditions. Repeated measures ANOVA will analyze factors such as gender and substance type to address study objectives, examining interactions and conducting planned contrasts for specific comparisons.",[64,65],"Substance Use Disorders","Substance Use",[67,68,69,70,71,72],"Ecological Momentary Assessment","Substance Use Disorder","Cocaine","Alcohol","Treatment","Gender","RECRUITING","2024-06-18",{"date":76,"type":41},"2024-06-24",{"date":78,"type":41},"2023-07-21",{"date":80,"type":22},"2025-08",{"name":47,"class":48},""]