[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Hull\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":102},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,46,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100537350","early-phase-1-exercise-for-improving-long-course-chemoradiotherapy-efficacy-in-people-with-locally-advanced-rectal-cancer-100537350",false,"NCT06276686","Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer","A Single Arm Feasibility Study of Exercise for Improving Long-course Chemoradiotherapy Efficacy in People With Locally Advanced Rectal Cancer","Inclusion Criteria:\n\n* 18 years or older\n* Have been diagnosed with locally advanced rectal cancer using MRI (Magnetic Resonance Imaging) and histological finding\n* Have been offered long-course neoadjuvant chemoradiotherapy in the Queens Centre, Castle Hill Hospital\n* Willing and able to comply with all study requirements\n* Able and willing to voluntarily give informed consent to take part.\n\nExclusion Criteria:\n\n* Inability to understand basic written and spoken English, as research materials will all be written in English.\n* Any movement deficiencies limiting ability to engage in exercise.\n* Impaired cognition and\u002For capacity limiting ability to provide informed consent.\n* Cardiovascular and\u002For cardiopulmonary conditions that will impede ability to safely perform exercise.\n* Severe psychiatric disorders.\n* With any other health condition which oncologists and research team agrees will impede ability to safely perform exercises.\n* Presence of metastatic cancer.","ALL","18 Years",{"count":19,"type":20},30,"ESTIMATED","INTERVENTIONAL",[23],"EARLY_PHASE1","This is a single arm feasibility study of exercise for improving long- course neoadjuvant chemoradiotherapy (NACRT) efficacy in people diagnosed with locally advanced rectal cancer. The study aims to recruit up to 30 patients from the Queen's Centre for Oncology and Haematology of Castle Hill Hospital, Cottingham, diagnosed with locally advanced rectal cancer. Consenting patients will be provided with an 11-week course of structured aerobic exercises and resistance training in the periods before, during and after their chemoradiotherapy treatment. The patients will be followed up for 6 months post long course neoadjuvant chemoradiotherapy (NACRT), with a total of 3 assessment periods.",[26],"Locally Advanced Rectal Carcinoma",[28,29,30,31,32],"Exercise","chemoradiotherapy","Treatment efficacy","Locally advanced rectal cancer","Vigorous intensity aerobic interval exercise","RECRUITING","2025-01-30",{"date":36,"type":37},"2025-02-04","ACTUAL",{"date":39,"type":37},"2024-12-10",{"date":41,"type":20},"2026-02-28",{"name":43,"class":44},"University of Hull","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":17,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":56,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":66,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100561834","exercise-for-ameliorating-chemotherapy-cardiotoxicity-100561834","NCT06595316","Exercise for Ameliorating Chemotherapy Cardiotoxicity","A Randomized Controlled Feasibility Trial of a Vigorous Intensity Aerobic Exercise and Resistance Training Intervention for Mitigating Chemotherapy Cardiotoxicity in Breast Cancer Patients","Inclusion Criteria:\n\n* Females between 18 to 75 years old.\n* Confirmed early stage (I-III) ER+ HER2 - breast cancer diagnosis\n* Undergoing adjuvant and neoadjuvant chemotherapy, consisting of epirubicin and cyclophosphamide (EC) followed by Docetaxel.\n* No contraindications to engage in physical activity.\n* Capable of giving informed consent.\n* Patients able to understand and communicate in English language\n\nExclusion Criteria:\n\n* Participants with cognitive disorders\n* Cancer metastases\n* Uncontrolled or serious illnesses that might hamper patients' capacity of exercising","FEMALE","75 Years",{"count":19,"type":20},[57],"NA","Chemotherapy is a common treatment for breast cancer but can damage the heart and blood vessels. Exercise, such as cycling, may stop chemotherapy from damaging the heart and blood vessels. Before the effects of exercise on the heart and blood vessels can be fully determined in a large trial, a small trial must first be carried out to assess if exercise can be included safely and practically during chemotherapy treatment.\n\nThis study is designed so that a group of breast cancer patients will exercise during their chemotherapy treatment, whilst another group does not exercise. Participants will be breast cancer patients from the Queen's Centre for Oncology and Haematology at Castle Hill Hospital. Suitable patients will be identified and approached by their Consultant Clinical Oncologist. If patients decide to take part, they will be randomly placed into groups ('exercise' or 'usual care') before starting chemotherapy. The exercise group will exercise for 50-60 minutes 2days\u002Fweek in the Cardiac Rehabilitation Gym at Castle Hill Hospital during their chemotherapy treatment. Exercise will be supervised, consisting of repeated 5-minute bouts of high intensity cycling plus strength training. The usual care group will be given their normal chemotherapy only (no exercise). Both groups will take part in tests before they begin chemotherapy treatment. Tests assess heart and blood vessel health, fitness, strength, fatigue, and quality of life. The same tests will happen again during the intervention, after the intervention and 3-months later. Participants will also have to complete questionnaires to give their opinion of the study. The main point of the study is to determine if the exercise and tests are received well by patients, if recruitment is good, and if patients comply\u002Fadhere. This will inform a larger study which will assess if exercise maintains heart and vessel health during chemotherapy treatment.",[60],"Cardiotoxicity",[62,63,64,65],"exercise","cardiotoxicity","exercise oncology","breast cancer","NOT_YET_RECRUITING","2024-09-10",{"date":69,"type":37},"2024-09-19",{"date":71,"type":20},"2024-10-15",{"date":73,"type":20},"2025-12-01",{"name":43,"class":44},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":54,"enrollmentInfo":83,"targetDuration":4,"studyType":21,"phases":85,"briefSummary":86,"conditions":87,"keywords":89,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":45},"100542365","bonefit-multimodal-prehabilitation-for-people-preparing-for-orthopaedic-surgery-100542365","NCT06341920","BoneFit: Multimodal Prehabilitation for People Preparing for Orthopaedic Surgery","BoneFit: A Student-led Multimodal Prehabilitation Service for Orthopaedic Surgical Patients in Hull","BoneFit","Inclusion Criteria:\n\n* Waiting for unilateral total hip or knee replacement surgery for a minimum of 6 months;\n* Able to provide informed consent;\n\nExclusion Criteria:\n\n* Previous hip or knee surgery;\n* Any medical conditions for which moderate to vigorous exercise is contraindicated;\n* Patellar or hip joint instability;\n* Any other disease\u002Fcondition which severely effects functional performance e.g. stroke or Parkinson's disease;\n* Chronic depression or significant psychiatric disorder;\n* Enrolled in a clinical trial (or recently completed one);\n* Cognitive impairment which would affect compliance to BoneFIt service;\n* Patients unable or unwilling to commit to required study follow-ups\n* Pregnancy;",{"count":84,"type":20},50,[57],"To conduct a pilot feasibility study to determine the effect of a student-led prehabilitation service in people awaiting total hip or knee replacement surgery.",[88],"Orthopedic Disorder",[90,91,92,93],"prehabilitation","optimisation","surgery","surgical preparation","2024-06-11",{"date":96,"type":37},"2024-06-12",{"date":98,"type":37},"2024-05-16",{"date":100,"type":20},"2027-12-01",{"name":43,"class":44},""]