[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Iceland\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":247},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,49,79,111,140,161,194,222],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100628708","multimodal-prehabilitation-of-frail-patients-undergoing-elective-knee-or-hip-replacement-100628708",false,"NCT07465159","Multimodal Prehabilitation of Frail Patients Undergoing Elective Knee or Hip Replacement","Multimodal Prehabilitation of Frail Patients 70 Years and Older Undergoing Elective Knee or Hip Replacement: A Pilot Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 70 years or older assigned to undergo hip\u002Fknee replacement at Landspítali University Hospital.\n* Inclusion will be offered to patients who have previously presented at the outpatient orthopedic department and been scheduled for an elective (with a waiting period ≥2 months before surgery) hip\u002Fknee replacement.\n* Patients who are willing to participate and sign informed consent and are willing to be randomized to the control or intervention arm.\n\nExclusion Criteria:\n\n* Patients who screen negative for all frailty tools will be excluded from the study.\n* Patients who are already in active physiotherapy, meeting with a physiotherapist \\>1 every month, will also be excluded.\n* In addition, those who do not undergo planned surgery, are undergoing redo hip\u002Fknee prosthesis replacement will be excluded","ALL","70 Years",{"count":19,"type":20},50,"ESTIMATED","INTERVENTIONAL",[23],"NA","Background: Frailty is a geriatric syndrome of reduced physiologic reserve that increases surgical risk and is common among older adults undergoing hip or knee replacement. While prehabilitation has shown promise in enhancing outcomes, evidence from randomized controlled trials (RCTs) in frail orthopedic patients is limited.\n\nObjective: This study aims to evaluate the feasibility and preliminary data on the effectiveness of a multimodal prehabilitation program for frail patients undergoing elective hip or knee arthroplasty.\n\nMethods: A pilot RCT will be conducted at Landspítali-University Hospital. Patients ≥70 years scheduled for surgery with ≥2 months waiting time will be screened for frailty using PRISMA-7, the Clock Drawing Test, and Timed Up \\& Go. Patients screening positive for any of the three screening tools will be randomized to multimodal prehabilitation or standard of care. The intervention includes comprehensive geriatric assessment, medication review, tailored physiotherapy using the Otago Exercise Programme, and nutritional counseling if at risk of malnutrition. We will conduct an external pilot for feasibility measures (overall enrollment, recruitment, retention, adherence). Secondary outcomes include physical performance, postoperative complications, patient-reported health status (WOMAC scale) and quality of life (EQ-5D-5L ), length of primary hospital stay, discharge location, falls postoperatively, 180-day readmission and 180-day mortality.\n\nSignificance: This trial may aid in the design of larger RCT study and provide a signal of the role of multimodal prehabilitation on outcomes, including quality of life and health status among frail arthroplasty patients.",[26,27,28,29],"Frailty Syndrome","Prehabilitation","Arthroplasties, Knee Replacement","Arthroplasties, Hip Replacement",[31,32,27,33,34,35],"Frailty","Arthroplasty","Multimodal prehabilitation","Knee replacement","Hip replacement","RECRUITING","2026-04-01",{"date":39,"type":40},"2026-04-07","ACTUAL",{"date":42,"type":40},"2026-03-20",{"date":44,"type":20},"2027-12-31",{"name":46,"class":47},"University of Iceland","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":48},"100628723","ocd-summer-treatment-program-for-adolescents-in-iceland-100628723","NCT07465354","OCD Summer Treatment Program for Adolescents in Iceland","Intensive OCD Summer Treatment Program for 12-18-year-old Adolescents in Iceland","OCDtreatment","Inclusion Criteria:\n\n* OCD diagnosis\n* Adolescents are fluent in Icelandic\n* Parents are fluent in Icelandic or English\n\nExclusion Criteria:\n\n* Intellectual disability\n* Severe suicidal ideation\n* Acute psychiatric disorders requiring immediate intervention, e.g. schizophrenia\n* Severely impairing levels of autism prohibiting group participation","12 Years","18 Years",{"count":60,"type":20},70,[23],"The aim of the study is to examine the effectiveness of OCD treatment delivered in a group format for adolescents during a two week intensive summer treatment program.",[64],"Obsessive-Compulsive Disorder (OCD)",[66,67,68,69],"Obsessive-compulsive disorder","Adolescents","intensive cognitive-behavioral treatment","Exposure and response prevention","NOT_YET_RECRUITING","2026-03-17",{"date":73,"type":40},"2026-03-18",{"date":75,"type":20},"2026-05-01",{"date":77,"type":20},"2033-09-01",{"name":46,"class":47},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":86,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":87,"targetDuration":89,"studyType":90,"phases":4,"briefSummary":91,"conditions":92,"keywords":97,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":106,"completionDateStruct":108,"leadSponsor":110,"locationsCount":48},"100627717","modified-essential-frailty-toolset-in-older-adults-undergoing-major-elective-surgery-100627717","NCT07452263","Modified Essential Frailty Toolset in Older Adults Undergoing Major Elective Surgery","Modified Essential Frailty Toolset for Predicting Postoperative Complications and Readmission in Older Adults Undergoing Major Elective Surgery","Inclusion Criteria:\n\n* Patients ≥ 70 years who present for preoperative work-up at the admissions department at Landspitali and undergo frailty screening.\n* Patients assigned to undergo major surgery\n\nExclusion Criteria:\n\n* Cardiac surgery\n* Not undergoing planned surgery",true,{"count":88,"type":20},250,"6 Months","OBSERVATIONAL","Frailty is a common geriatric syndrome associated with reduced physiological reserve and increased vulnerability to surgical stress. As the population ages, more older adults undergo major elective surgery, yet frailty is often insufficiently assessed in routine practice and no universally accepted screening tool exists.\n\nThe Essential Frailty Toolset (EFT) is a simple validated frailty assessments and has demonstrated strong predictive value for mortality and major postoperative complications, particularly in cardiac surgery populations. EFT incorporates four key domains of cognition, anemia, serum albumin, and physical function capturing both physical and cognitive vulnerability. A modified version (mEFT) has been developed to improve feasibility and applicability in broader surgical settings, requiring minimal training and only a few minutes to administer. Despite its promise, mEFT has not been evaluated in elderly patients undergoing major elective non-cardiac surgery, representing an important gap in the current literature and motivating the present study.\n\nWe therefore propose a modified and simplified frailty screening tool tailored for elderly patients undergoing major elective non-cardiac surgery at our institution. The modified Essential Frailty Toolset (mEFT) is a multi-dimensional assessment designed to address this gap by evaluating physical function, cognition, nutrition, and anemia in just a few minutes. In this version, the tool assigns points based on specific clinical markers: the Timed Up and Go (TUG) test provides one point for a time ≥11.0 seconds and two points for ≥15.0 seconds; the Clock Drawing Test (CDT) provides one point for a score of ≤2 on a 3-point scale; nutritional risk is captured with one point for a BMI \\\u003C22.0 or unintentional weight loss of 5% over the last six months; and anemia provides one point based on hemoglobin levels (below 130g\u002FL for men and 120 g\u002FL for women). These modifications were made to enhance feasibility and clinical relevance in our population. Low serum albumin was rare in our cohort and therefore demonstrated limited discriminatory value as a screening marker. In contrast, low BMI and recent weight loss are well-established risk factors for malnutrition and sarcopenia and are readily obtainable in routine preoperative assessment. Similarly, both the TUG and CDT are quick, inexpensive, and require minimal training, making them well suited for large-scale screening in preoperative clinics.Importantly, the proposed components have been evaluated in a pilot study conducted in our institution.\n\nThis study will evaluate whether a high mEFT score (≥3) is associated with increased postoperative complications and 90-day readmissions among patients aged ≥70 years undergoing major elective surgery. Patients presenting for admission will be included. If mEFT accurately identifies high-risk patients, it may improve preoperative risk stratification, inform shared decision-making, and help identify individuals who could benefit from targeted prehabilitation, supporting broader implementation of frailty screening in surgical care.",[93,26,94,95,96],"Frailty in Adult Surgery","Elective Surgeries","Readmission Rates","Postoperative Complication",[31,98,99,100,101,102],"Postoperative Outcomes","Major elective surgery","Surgical Frailty","Readmission","Complications","2026-03-06",{"date":105,"type":40},"2026-03-10",{"date":107,"type":40},"2025-01-20",{"date":109,"type":20},"2026-12-31",{"name":46,"class":47},{"id":112,"slug":113,"hasResults":11,"nctId":114,"briefTitle":115,"officialTitle":116,"acronym":117,"eligibilityCriteria":118,"healthyVolunteers":11,"sex":16,"minAge":119,"maxAge":57,"enrollmentInfo":120,"targetDuration":4,"studyType":21,"phases":122,"briefSummary":123,"conditions":124,"keywords":126,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":4},"100622110","the-adhd-kids-study-for-children-9-12-years-of-age-100622110","NCT07379359","The ADHD Kids´ Study for Children 9-12 Years of Age","The ADHD Kids´ Study: Randomized Clinical Trial on the OutSMARTers Program and Individual Counseling for Children Aged 9-12 With ADHD","OutSmarters","Inclusion Criteria:\n\n* age: 9-12\n* have an ADHD diagnosis confirmed by a school psychologist\n* children need to be fluent in Icelandic\n* Parents need to be fluent in Icelandic or English\n\nExclusion Criteria:\n\n* Children need to have an IQ of 70 or higher (WISC-IV test or WPSSI-R test)","9 Years",{"count":121,"type":20},100,[23],"The aim of the study is to compare the efficacy of The OutSMARTers program- an ADHD skills training group program for children aged 9-12 to customized individual counseling provided by a professional, The Kid Counseling Program. Approximately 100 children will be randomly assigned to either intervention or a small wait-list group who will after a five-week-waiting period receive either intervention. Following the intervention, parents, children, and teachers will evaluate the effects on communication skills, well-being, and emotional regulation.",[125],"Attention-Deficit\u002FHyperactivity Disorder (ADHD)",[127,128,129,130,131],"Intervention program for ADHD","Children","OutSMARTers Program","Skill building","Cognitive-behavioral therapy","2026-01-26",{"date":134,"type":40},"2026-01-30",{"date":136,"type":20},"2026-01-02",{"date":138,"type":20},"2029-10-01",{"name":46,"class":47},{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":4,"eligibilityCriteria":146,"healthyVolunteers":86,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":147,"targetDuration":149,"studyType":90,"phases":4,"briefSummary":150,"conditions":151,"keywords":153,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":157,"completionDateStruct":158,"leadSponsor":160,"locationsCount":48},"100621223","validity-of-frailty-screening-tools-as-a-measure-for-postoperative-outcomes-100621223","NCT07367828","Validity of Frailty Screening Tools as a Measure for Postoperative Outcomes","Feasibility and Validity of Frailty Screening Tools as a Measure of Postoperative Outcomes in Older Patients Undergoing Elective Surgery","Inclusion Criteria:\n\n* Patients ≥ 70 years who present for preoperative work-up at the anesthesia department at Landspitali.\n* Patients assigned to undergo intermediate\u002Fmajor surgery\n\nExclusion Criteria:\n\n* Not undergoing planned surgery",{"count":148,"type":20},350,"1 Year","Frailty is a common geriatric syndrome defined as a clinical state of decreased physiologic reserve resulting in increased vulnerability to stressors. It is associated with several unfavorable postoperative complications independent of age such as readmission, length of hospital stay and mortality. To address these concerns, medical societies have acknowledged a need for routine screening to identify elderly patients who are at high risk for major complications before undergoing surgery.\n\nIn the absence of a golden standard for frailty assessment, there are multiple assessment tools available. However, the challenge with many frailty tools is that they can be time-consuming, and require expertise and clinical training.This poses a challenge for screening a large elderly population before surgery. Some frailty assessment tools, such as PRISMA7 (The Program of Research to Integrate Services for the Maintenance of Autonomy), timed up and go (TUG) and the clock drawing test (CDT), have been demonstrated to be quick, simple and easy to use with minimal training.\n\nThe PRISMA-7 is a frailty screening questionnaire that consists of seven dichotomous items considering age, gender, health problems that affect activities of daily living (ADLs), assistance from others with ADLs, having to count on someone if needed, and the use of mobility aids.\n\nThe TUG test is used for assessing fall risk and frailty in older patients. It is measured by the time it takes an individual to stand up from a seated position, walk three meters and return back to a seated position. There is no standard cut-off for TUG, however, a cut-off of \\> 10 seconds has been used to identify frailty.\n\nCognitive impairment in older surgical patients may predispose patients to executive dysfunction that many elderly patients experience postoperatively and has shown to be a risk factor for surgical complications. Some studies suggest a strong relationship between cognitive impairment and physical frailty resulting in cognitive frailty when evaluating older adults.The CDT has shown to be a valuable screening tool for cognitive concerns. When administering the CDT, a patient receives instructions to draw a clock. Performing the test requires auditory comprehension, planning, sustained attention, visual-spatial skills and executive skills.\n\nThe prevalence of surgical frailty in Iceland has not been researched thoroughly enough to provide an accurate estimate. This is important to reveal the number of senior surgical patients at high risk of adverse postoperative outcomes who could benefit from a preoperative intervention. However, there is a lack of consensus on an optimal frailty assessment to screen patients for identifying frail patients prior to surgery, and more research is needed to evaluate which group of patients would benefit the most from prehabilitation.\n\nThe scientific value of this study is to elucidate the extent of frailty risk and its associated postoperative outcomes in older surgical patients undergoing elective surgery. We opt to find a convenient screening routine prior to surgery to identify patients at risk of frailty. Therefore, the study aims to validate three frailty screening methods and to assess a positive screening result as an independent risk factor for adverse postoperative outcomes in a cohort of elderly surgical patients undergoing elective surgery. We hypothesize that elderly patients at risk of frailty have a higher rate of surgical complications than patients not at risk of frailty.\n\nPatients aged ≥ 70 years who undergo elective surgery will be prospectively examined at the Department of Anesthesiology and Critical Care of Landspítali. The screening assessments to be evaluated are the Program of Research to Integrate Services for the Maintenance of Autonomy (PRISMA-7), a combination of Timed Up \\& Go (TUG), Clock Drawing Test (CDT) and the FRAIL questionnaire, and a combination of PRISMA-7, TUG and CDT. Additional clinical data and outcomes will be obtained from the electronic medical records of Landspítali. The postoperative outcomes measured will be 180-day mortality, surgical complications, 90-day readmission, delirium, non-home discharge and length of hospital stay.\n\nPatients who screen positive on the CDT (≤ 2\u002F3 points) and TUG (≥ 11 seconds) will be considered frail. Those who do not screen positive on both of these tests will be part of the control group (non-frail).",[93,26,152],"Elective Surgery",[31,98,99,100,154],"Intermediate elective surgery","2026-01-19",{"date":132,"type":40},{"date":107,"type":40},{"date":159,"type":20},"2026-12-21",{"name":46,"class":47},{"id":162,"slug":163,"hasResults":11,"nctId":164,"briefTitle":165,"officialTitle":166,"acronym":167,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":16,"minAge":169,"maxAge":170,"enrollmentInfo":171,"targetDuration":4,"studyType":21,"phases":173,"briefSummary":174,"conditions":175,"keywords":183,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":48},"100562203","effect-of-educational-intervention-on-childrens-anxiety-100562203","NCT06600113","Effect of Educational Intervention on Children's Anxiety","Evaluating Effectiveness of Different Educational Methods on the Anxiety of Children Undergoing Anaesthesia - a Randomized Controlled Trial","MINA","Inclusion Criteria:\n\n* Undergoing anesthesia for medical procedure\n\nExclusion Criteria:\n\n* Does not understand Icelandic\u002FFinnish","4 Years","8 Years",{"count":172,"type":20},150,[23],"The aim of this randomized controlled trial is to evaluate the effectiveness of an educational health game intervention for children undergoing anesthesia from the perspective of children's anxiety. Participants are divided into three groups: one plays an educational game, another gets similar educational material (story) on a website and the third receives usual care. Anxiety will be evaluated with a standard assessment tool at the medical centre and parents answer questionnaires about themselves and their child. The study is an important step into innovation in the field of patient education where computer games are used to disseminate information, teach salvation and promote faith in the child's own ability and courage. The study will provide important information on children's anxiety for anaesthesia and what the effects of the computer game are compared to other educational methods.",[176,177,178,179,180,181,182],"Health Literacy","Anesthesia","Anxiety","Fear","Attitude","Child Behavior","Health Knowledge, Attitudes, Practice",[128,184,177,185],"Game","Health literacy","2024-09-12",{"date":188,"type":40},"2024-09-19",{"date":190,"type":40},"2022-11-21",{"date":192,"type":20},"2025-05-01",{"name":46,"class":47},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":16,"minAge":202,"maxAge":203,"enrollmentInfo":204,"targetDuration":4,"studyType":90,"phases":4,"briefSummary":206,"conditions":207,"keywords":209,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":221,"locationsCount":4},"100387896","meals-microbiota--mental-health-of-children--adolescents-100387896","NCT04330703","Meals, Microbiota & Mental Health of Children & Adolescents","Meals, Microbiota & Mental Health of Children & Adolescents. An Observational, Longitudinal Case-control Study.","MMM","Inclusion Criteria:\n\nChildren and adolescents (both genders; 5-15y) referred for their first visit to the outpatient clinic at the Child and Adolescent Psychiatry Department (BUGL)\n\nExclusion Criteria:\n\n* A diagnosis of mental health disorder (ICD10)\n* Antibiotics use for the last six months","5 Years","15 Years",{"count":205,"type":20},30,"Recent studies indicate that the interplay between diet, intestinal microbiota composition, and intestinal permeability might impact mental health. The aim of thisl study is to compare diet, intestinal microbiota, intestinal permeability, and related metabolic factors among children and adolescents diagnosed with mental health disorders and control groups and identify potential relationship patterns. All children and adolescents referred to the outpatient clinic at the Child and Adolescent Psychiatry Department at The National University Hospital in Reykjavik Iceland will be offered to participate (n=15) (age 5-15 years). Two control groups will be used; the same parent siblings close in age (n=x) as well as age and sex-matched children from the same postal area (n=15). A three-day food diary, rating scales for mental health and multiple questionnaires will be completed as well as faecal sample, buccal swab, urine, saliva and blood samples will be collected. This is a novel approach as more multidimensional transdisciplinary studies including longitudinal observational data have been called for as a basis for lifestyle treatment options for improving mental health and wellness.",[208],"Mental Disorder",[210,211,212,213,214],"Microbiota","Microbiome","Intestinal permeability","Children & adolescents","Mental health","2024-02-07",{"date":217,"type":40},"2024-02-08",{"date":219,"type":20},"2024-03-15",{"date":109,"type":20},{"name":46,"class":47},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":4,"eligibilityCriteria":228,"healthyVolunteers":86,"sex":16,"minAge":229,"maxAge":57,"enrollmentInfo":230,"targetDuration":4,"studyType":21,"phases":232,"briefSummary":233,"conditions":234,"keywords":236,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":48},"100531069","emotion-regulation-as-a-moderator-of-two-different-treatments-for-children-with-odd-100531069","NCT06194994","Emotion Regulation as a Moderator of Two Different Treatments for Children With ODD","Emotion Regulation as a Moderator of Two Different Treatments for Children With Oppositional Defiant Disorder: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Diagnosed with Oppositional Defiant Disorder\n* Icelandic speaking (child and parent\u002Fguardian)\n\nExclusion Criteria:\n\n* IQ below 70 (full scale score)","6 Years",{"count":231,"type":20},196,[23],"The goal of this randomized controlled trial is to is to test emotion regulation as a moderator of two different treatments for children with Oppositional Defiant Disorder (ODD). The main question it aims to answer is whether treatment gains be increased when children with ODD receive a treatment congruent with their emotion regulation skill problems. Participants will be divided into two groups based on their response patterns; a high emotion dysregulation group and a low emotion dysregulation group. Within each group, children will then be randomly assigned to either a behavioral parent training intervention or a child directed treatment involving problem solving and emotion regulation skills.",[235],"Oppositional Defiant Disorder",[235,237,238],"Emotion Regulation","Child Psychopathology","2024-01-05",{"date":241,"type":40},"2024-01-08",{"date":243,"type":40},"2024-01-04",{"date":245,"type":20},"2029-12",{"name":46,"class":47},""]