[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Illinois at Urbana-Champaign\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":552},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,48,75,101,137,165,187,212,241,267,290,315,345,373,400,431,459,482,502,530],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100605834","fall-prevention-among-people-with-spinal-cord-injury-and-multiple-sclerosis-who-use-wheelchairs-and-scooters-100605834",false,"NCT07167680","Fall Prevention Among People With Spinal Cord Injury and Multiple Sclerosis Who Use Wheelchairs and Scooters","Development and Validation of a mHealth Fall Management Program - Phase III","Inclusion Criteria:\n\n* 18 years old or older.\n* History of Multiple Sclerosis (MS) or Spinal Cord Injury (SCI).\n* Able to transfer independently or with minimal to moderate assistance.\n* Unable to walk 25 feet or more\n* Have experienced at least 1 fall in the past three years.\n* Have a care partner to assist the participant when practicing physical skills.\n* Have access to a smartphone\u002FiPad.\n* Have a stable internet connection.\n\nExclusion Criteria:\n\n* Multiple sclerosis exacerbation in the past 30 days, or are unable to remain in an upright position for an hour.\n* Impaired cognition (a score of 10 or above on the Short Blessed Test).","ALL","18 Years",{"count":19,"type":20},120,"ESTIMATED","INTERVENTIONAL",[23],"NA","The research team is conducting a study to determine if a fall prevention program designed specifically for people who use wheelchairs and scooters can help people better prevent and manage falls compared to the standard of care.\n\nThis study will compare two groups of participants:\n\n1. One group will use the iROLL-O+ app, which offers personalized fall prevention tools and strategies.\n2. The other group will receive fall prevention information from a well-known program developed by the Centers for Disease Control and Prevention (CDC), called STEADI, which stands for Stopping Elderly Accidents, Deaths, and Injuries.\n\nThis study includes adults living with Spinal Cord Injury (SCI) or Multiple Sclerosis (MS) who use a wheelchair or scooter every day. The research team aims to determine which approach is more effective in reducing falls and improving confidence in performing daily activities.",[26,27],"Spinal Cord Injuries (SCI)","Multiple Sclerosis",[29,30,31,32,33,34],"wheelchair","fall prevention","mobile application","spinal cord injury","multiple sclerosis","education","RECRUITING","2026-05-06",{"date":38,"type":39},"2026-05-11","ACTUAL",{"date":41,"type":39},"2025-09-01",{"date":43,"type":20},"2027-12-01",{"name":45,"class":46},"University of Illinois at Urbana-Champaign","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":21,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":47},"100594537","stable-isotopes--adults-with-obesity-100594537","NCT07020741","Stable Isotopes- Adults With Obesity","Assessing Metabolic Health With Stable Isotope Tracer Techniques in Adults With Obesity","Si-OBA","Inclusion Criteria:\n\n* ages 19-59\n* Obese \\>\u002F= 30 kg\u002Fm\\^2 and \\>\u002F= 102 cm for males and \\>\u002F= 88 cm for females\n* Godin Leisure-time or exercise questionnaire \\\u003C14 units\n\nExclusion Criteria:\n\n1. Pregnant or become pregnant\n2. Any known food allergies\n3. Smoker\n4. Are physically active\n5. Have any known metabolic diseases\n6. Have been weight unstable within the last 6 months (lost or gained \\>10% of body mass)\n7. Non eumenorrheic or on a hormonal birth control",true,"19 Years","59 Years",{"count":60,"type":20},8,[23],"In a crossover design, 8 participants will receive caloric drinks containing stable isotopes. In one arm of the study, participants will consume 6 hourly drinks containing two stable isotopes. Repeated blood, breath, urine, and muscle biopsies will be taken. In the second arm, participants will consume 1 drink containing 75g glucose, labeled with two stable isotopes of glucose. Periodic blood and breath will be taken over three hours.",[64,65,66],"Obese Patients (BMI ≥ 30 kg\u002Fm²)","Glucose Metabolism","Protein Metabolism","2026-04-28",{"date":69,"type":39},"2026-04-29",{"date":71,"type":39},"2025-09-12",{"date":73,"type":20},"2026-12-31",{"name":45,"class":46},{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":56,"sex":16,"minAge":83,"maxAge":4,"enrollmentInfo":84,"targetDuration":4,"studyType":21,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":47},"100629622","exercise-and-protein-efficiency-in-t2d-100629622","NCT07477067","Exercise and Protein Efficiency in T2D","Exercise Impact on Dietary Protein Efficiency in Older Adults With Type 2 Diabetes","ADA","Inclusion Criteria:\n\n* At least 65 years old\n* Body mass index: 25-40 kg\u002Fm\\^2\n* Female: Waist to hip ratio \\>0.8\n* Male: Waist to hip ratio \\>1.0\n* Free from structured exercise during the prior 6 months (mo) weight stable for the prior 6 months\n\nT2D group:\n\n-Diagnosed by a physician with elevated glycosylated hemoglobin (HbA1c) \\>6.5%\n\nControl group:\n\n-Normoglycemic with HbA1c levels not exceeding 5.6% and fasting blood glucose levels below or equal to 99 mg\u002FdL (5.5mmol)\n\nExclusion Criteria:\n\n* Uncontrolled diabetes (evidence of HbA1c \\> 10%, prescription of insulin)\n* Diagnoses of diabetic neuropathy or failing diabetic neuropathy screening\n* Statins\n* Peripheral edema Consumption of ergogenic-levels of dietary supplements that may affect muscle mass (e.g., creatine, HMB), insulin-like substances, or anabolic\u002Fcatabolic pro-hormones (e.g., DHEA) within 6 weeks prior to participation.\n* Untreated hypothyroidism, epilepsy, medications that affect vasoactivity, possibility of pregnancy, and any neurological, cardiovascular, or musculoskeletal disease that precludes exercise testing.","65 Years",{"count":85,"type":20},30,[23],"In this randomized controlled trial, 30 older adults (aged\\> 65 years; 15 with T2D, 15 controls) will participate in a 12-week progressive exercise training program. They will undergo pre- and post-testing that includes body composition measures; oral glucose tolerance testing; cardiovascular fitness and muscle performance testing; dietary protein efficiency assessed using the indicator amino acid oxidation (IAAO) method; and a gut microbiota trial. The dietary protein efficiency trial will include repeated ingestion of crystallized amino acids (drink) containing stable isotopes, urine samples, and breath samples. The gut microbiome trial will consist of a single ingestion of a Mediterranean-based modeled meal enriched with 13C-phenylalanine (in the drink) and repeated blood draws. Participants will also be asked to give a fecal sample after the gut microbiome trial.",[89,90],"Type 2 Diabetes","Control Condition",[89,92,93,66],"Obesity","Exercise Intervention","2026-04-27",{"date":69,"type":39},{"date":97,"type":39},"2026-02-09",{"date":99,"type":20},"2028-07-01",{"name":45,"class":46},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":56,"sex":16,"minAge":57,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":21,"phases":112,"briefSummary":113,"conditions":114,"keywords":120,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":136},"100621225","diet-synergy-in-muscle-protein-synthesis-100621225","NCT07367854","Diet Synergy in Muscle Protein Synthesis","Impact of Food Combinations on the Stimulation of Post-exercise Muscle Protein Synthesis in Healthy Adults","POTATO","Inclusion Criteria:\n\n* Age 19-40 yrs\n* Pre-menopausal\n* Recreationally-active\n* Weight stable for prior 6 months\n\nExclusion Criteria:\n\n* Age outside of range (20 - 35 yrs)\n* Pregnancy\n* Irregular menstrual cycles (i.e., \\~21 day or \\~35 day cycle)\n* Participation in previous research using L-\\[1-13C\\] leucine and L-\\[ring-2H5\\] phenylalanine\n* Participation in other ongoing research that interferes with this study (e.g., conflicting diet, activity interventions, etc.)","40 Years",{"count":111,"type":20},15,[23],"In the present semi-crossover randomized design, 15 recreationally active young adults (19-40 y) will receive stable isotope tracer infusions and perform a single bout of resistance exercise. Immediately after exercise, participants will ingest either 1 medium russet potato with skins and 2 ounce-equivalent lean ground beef combination (274 kcals, 19.3 g protein, 5 g fat, 37 g carbohydrates, and 4 g fiber), 2 slices of white bread and beef combination (262 kcals, 19.8 g protein, 6.8 g fat, 28 g carbohydrates, and 1.8 g fiber) or 2 ounce-equivalent beef (93% lean meat\u002F7% fat; 110 kcals, 14.8 g protein, and 5 g fat). Repeated blood and muscle biopsies will be collected to determine whole body leucine kinetics, amino acid concentrations, anabolic signaling and myofibrillar protein synthesis rates during the trials.",[115,116,117,66,118,119],"Muscle Protein Synthetic Response to Protein","Muscle Protein Synthesis","Muscle Health","Recreational Activities","Isotope Labeling",[121,122,123,124,125,126,127,128],"protein","leucine kinetics","food matrix","protein synthesis","potato","stable isotope tracers","constant infusions","food combinations",{"date":130,"type":39},"2026-05-01",{"date":132,"type":39},"2026-03-01",{"date":134,"type":20},"2028-11-01",{"name":45,"class":46},2,{"id":138,"slug":139,"hasResults":11,"nctId":140,"briefTitle":141,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":56,"sex":16,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":21,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":164},"100488388","intervention-to-prevent-behavioral-health-symptoms-among-pandemic-affected-children-100488388","NCT05639465","Intervention to Prevent Behavioral Health Symptoms Among Pandemic Affected Children","Pragmatic RCT of a Multi-level Mechanistically Informed Community Intervention to Prevent the Onset of Behavioral Health Symptoms Among Socioeconomically Disadvantaged Pandemic Affected Children","Inclusion Criteria:\n\n* child experienced the COVID-19 pandemic and an additional large-scale disaster\n* child score is 5 or above on the Strengths and Difficulties Questionnaire\n* child is in 3- 8th grade at enrollment\n* the parent or guardian must complete informed consent and child assent\n* child must speak English or Spanish.\n\nExclusion Criteria:\n\n* child is currently receiving treatment for a diagnosed mental health condition\n* children who are not able to interact with other students in a group work format, regardless of IEP status","8 Years","14 Years",{"count":147,"type":20},800,[23],"Racial and ethnic minority children who live in socioeconomically disadvantaged communities are disproportionately impacted by pandemic and climate-induced disasters. Although effective interventions have been designed to treat mental health related symptoms in post-disaster settings, accessible, empirically supported prevention interventions are needed to prevent the onset of mental and behavioral health issues among these children. Building on our preliminary findings, the proposed study examines the efficacy and implementation of a COVID-19 adapted disaster focused prevention intervention, Journey of Hope-C19, in preventing behavioral health and interpersonal problems among racial and ethnic minority children who live in low-resource high poverty communities.",[151,152,153,154,155],"Emotional Distress","Prosocial Behavior","Pandemic, COVID-19","Coping Skills","Social Support","2026-01-21",{"date":158,"type":39},"2026-01-23",{"date":160,"type":39},"2022-11-15",{"date":162,"type":20},"2027-05-15",{"name":45,"class":46},9,{"id":166,"slug":167,"hasResults":11,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":21,"phases":174,"briefSummary":175,"conditions":176,"keywords":4,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":4},"100620057","5-verbs-for-couples---pilot-study-100620057","NCT07352670","5 Verbs for Couples - Pilot Study","5 Verbs for Couples: Program Study","Inclusion Criteria:\n\n* A resident of United States\n* 18 years of age or older\n* Married, engaged, or living with your partner for at least 6 months\n* Willing to participate in online relationship-focused programming\n\nExclusion Criteria:\n\n* Severe form(s) of intimate partner violence are occurring in the relationship",{"count":173,"type":20},200,[23],"The current research is designed to implement and evaluate 5 Verbs for Couples, a new relationship education program that can be completed individually or by both partners together. Involvement will entail completing 3 surveys over a 2-month period. After completing the first survey, a subset of individuals will be randomly assigned to participate in a 3-session online program and answer questions about their experience in the program. The remaining individuals will receive access to the program approximately 2 months later, after completing the third survey.",[177],"Relationships, Marital","NOT_YET_RECRUITING","2026-01-09",{"date":181,"type":39},"2026-01-20",{"date":183,"type":20},"2026-04-01",{"date":185,"type":20},"2028-12",{"name":45,"class":46},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":194,"targetDuration":4,"studyType":21,"phases":196,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":47},"100617841","assessment-of-a-method-to-improve-cochlear-implant-users-speech-perception-in-noisy-environments-while-maintaining-their-ability-to-determine-where-a-sound-originates-from-100617841","NCT07323862","Assessment of a Method to Improve Cochlear Implant Users' Speech Perception in Noisy Environments While Maintaining Their Ability to Determine Where a Sound Originates From","Spatially Transparent Binaural Beamforming for Noise Reduction for Cochlear Implant Processors","Inclusion Criteria:\n\n* Participants must have bilateral cochlear implants from Cochlear or Advanced Bionics\n\nExclusion Criteria:\n\n* Non-native English speakers",{"count":195,"type":20},25,[23],"The goal of this clinical trial is to determine if a new algorithm can improve speech perception for cochlear implant users. The main questions it aims to answer \\[is\u002Fare\\]:\n\n* Does the algorithm improve speech perception in noisy environments?\n* Does the algorithm allow listeners to determine where a sound is coming from?\n\nParticipants will\n\n* Listen to and repeat sentences presented in the presence of noise\n* Indicate the location that sounds originated from",[199],"Cochlear Implant Users",[201,202,203],"Beamforming","Speech perception in noise","Localization","2026-01-06",{"date":206,"type":39},"2026-01-07",{"date":208,"type":20},"2026-01-01",{"date":210,"type":20},"2026-08-31",{"name":45,"class":46},{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":218,"eligibilityCriteria":219,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":220,"enrollmentInfo":221,"targetDuration":4,"studyType":21,"phases":223,"briefSummary":224,"conditions":225,"keywords":230,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":47},"100614927","mindfulness-walking-intervention-to-enhance-resilience-iwalk-100614927","NCT07285954","Mindfulness Walking Intervention to Enhance Resilience (iWalk)","A Randomized Controlled Trial of a Walking Meditation Intervention (iWalk) to Enhance Resilience in Adults","iWalk","Inclusion Criteria:\n\n1. 18 years or older,\n2. clinical diagnosis of a neurodegenerative disease such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, stroke, etc.,\n3. have not practiced meditation regularly (e.g., 10 mins per day) and have never attended any meditation classes or community programs,\n4. never received meditation training via coaching\u002Fcertification\u002Flife coaching,\n5. have internet access,\n6. with no severe cognitive impairment, i.e., have a score of ≥ 21 on Modified Telephonic Interview for Cognitive Status (TICS-M),\n7. be able to walk with or without an assistive device (Patient determined Disease Steps score ranged from 0-6),\n8. are willing to be randomized to an intervention or a control group,\n9. are willing to wear Fitbit (a wrist smart watch) for eight weeks,\n10. are individuals who are right-handed according to the Edinburgh Handedness Questionnaire,\n11. are willing to participate in all assessments, including in-person testing using electroencephalography (EEG) and cognitive tests, online survey\u002Fquestionnaires, and online interviews or focus group discussions,\n12. are willing to wear a Hexoskin t-shirt, which is a heart rate variability monitor, while doing the assessments in person.\n\nExclusion Criteria:\n\nParticipants who cannot speak, read, write, or listen in English.","110 Years",{"count":222,"type":20},90,[23],"This study is a randomized controlled trial of the walking meditation intervention (iWalk) program, a multi-component intervention integrating walking meditation, education, and group sessions designed to enhance resilience in individuals with multiple sclerosis (MS).\n\nThe objectives are to evaluate:\n\n1. Recruitment capability and retention rates,\n2. Acceptability and adherence to the intervention,\n3. Feasibility of assessment procedures, and\n4. Preliminary effects on psychological, physiological, and behavioral outcomes.",[226,227,228,229],"Neurodegenerative Disease","EEG","Mindfulness","Adults",[231,232,227],"Walking meditation","Emotional regulation","2025-12-02",{"date":235,"type":39},"2025-12-16",{"date":237,"type":39},"2025-06-01",{"date":239,"type":20},"2029-12-31",{"name":45,"class":46},{"id":242,"slug":243,"hasResults":11,"nctId":244,"briefTitle":245,"officialTitle":245,"acronym":4,"eligibilityCriteria":246,"healthyVolunteers":56,"sex":16,"minAge":247,"maxAge":248,"enrollmentInfo":249,"targetDuration":4,"studyType":21,"phases":250,"briefSummary":251,"conditions":252,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":136},"100602593","alcohol-and-the-social-brain-an-alcohol-administration-hyperscanning-study-employing-a-within-subject-design-100602593","NCT07125534","Alcohol and the Social Brain: An Alcohol-Administration Hyperscanning Study Employing a Within-Subject Design","Inclusion Criteria:\n\n* Between the ages of 21 and 30\n* Regularly consumes alcohol\n\nExclusion Criteria:\n\n* History of adverse reaction to the amount of beverage employed in the study\n* Have a history of major problems associated with alcohol\n* Take medications that could adversely interact with alcohol\n* Have medical conditions that contraindicate alcohol administration\n* Individuals with a history of skull fractures or who indicate discomfort with EEG procedures used\n* Female participant is pregnant or trying to become pregnant","21 Years","30 Years",{"count":173,"type":20},[23],"The study investigates the effects of alcohol consumption on social and individual behaviors using a within-subject design. Participants, aged 21-30, will attend two laboratory sessions approximately one week apart, participating as part of a dyad (pair). During one session, they will consume an alcoholic beverage, while in the other, they will receive a control beverage, with the order of conditions randomized. This design facilitates direct within-participant comparisons of behaviors and neural activity in intoxicated versus sober states.\n\nTo achieve these aims, the study employs EEG technology to explore intra-brain and inter-brain dynamics during social interactions. Additionally, validated self-report questionnaires will capture data on mood, social bonding, and other psychological variables. The findings are expected to enhance understanding of alcohol's role in social reward processes and contribute to developing evidence-based prevention and intervention strategies for alcohol use disorder.",[253,254,255,256,257,258],"Alcohol Drinking","Alcohol Use Disorder (AUD)","Alcohol Intoxication","Alcohol; Harmful Use","Alcoholism","Binge Drinking","2025-08-22",{"date":261,"type":39},"2025-08-29",{"date":263,"type":39},"2025-08-09",{"date":265,"type":20},"2028-05",{"name":45,"class":46},{"id":268,"slug":269,"hasResults":11,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":21,"phases":277,"briefSummary":278,"conditions":279,"keywords":280,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":283,"lastUpdatePostDateStruct":284,"startDateStruct":286,"completionDateStruct":288,"leadSponsor":289,"locationsCount":47},"100448833","an-individualized-health-elibrary-app-for-people-with-multiple-sclerosis-100448833","NCT05124600","An Individualized-health eLibrary App for People With Multiple Sclerosis","An Individualized-health eLibrary App for People With Multiple Sclerosis: Testing Feasibility and Effectiveness of a Brief Education Intervention","SavvyHealth","Inclusion Criteria:\n\n* diagnosed with MS;\n* 18 years or older;\n* one comorbidity evaluated by a validated comorbidity questionnaire for people with MS;\n* willing to take a survey;\n* willing to use the app for 21 days;\n* willing to be assigned to either the intervention or control group.\n\nExclusion Criteria:\n\n\\-",{"count":276,"type":20},60,[23],"The purpose of this study is to assess the effectiveness after using a new individualized-health e-library app named SavvyHealth among people with multiple sclerosis.",[27],[281,282],"eHealth","mHealth","2025-08-18",{"date":285,"type":39},"2025-08-24",{"date":287,"type":39},"2021-10-25",{"date":73,"type":20},{"name":45,"class":46},{"id":291,"slug":292,"hasResults":11,"nctId":293,"briefTitle":294,"officialTitle":294,"acronym":4,"eligibilityCriteria":295,"healthyVolunteers":56,"sex":16,"minAge":247,"maxAge":4,"enrollmentInfo":296,"targetDuration":4,"studyType":298,"phases":4,"briefSummary":299,"conditions":300,"keywords":301,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":307,"lastUpdatePostDateStruct":308,"startDateStruct":310,"completionDateStruct":312,"leadSponsor":314,"locationsCount":47},"100492491","towards-a-wearable-alcohol-biosensor-examining-the-accuracy-of-bac-estimates-from-new-generation-transdermal-technology-using-large-scale-human-testing-and-machine-learning-algorithms-100492491","NCT05692830","Towards a Wearable Alcohol Biosensor: Examining the Accuracy of BAC Estimates From New-Generation Transdermal Technology Using Large-Scale Human Testing and Machine Learning Algorithms","Inclusion Criteria:\n\n* 21 years or older\n* drink alcohol at least 2x weekly\n\nExclusion Criteria:\n\n* psychological or medical conditions that might contraindicate alcohol-administration\n* history of adverse reaction to type and amount of beverage used in the study\n* currently seeking treatment for alcohol use disorder\n* does not drink alcohol regularly\n* taking drugs or medications for which alcohol consumption would be contraindicated\n* women who are pregnant or are attempting to become pregnant",{"count":297,"type":20},240,"OBSERVATIONAL","The study will employ a combined laboratory-ambulatory design. Participants will engage in ambulatory assessment over the course of 14 days, wearing biosensors assessing transdermal alcohol concentration (TAC) and providing breathalyzer readings in real-world contexts. Also during this period, participants will attend three laboratory alcohol-administration sessions scheduled at one-week intervals, with alcohol dose and rate of consumption manipulated within and between participants, respectively. Laboratory visits will also double as ambulatory orientation, check-in, and close-out sessions.",[253,255],[302,303,304,305,306],"transdermal alcohol content","ambulatory","transdermal biosensor","machine learning algorithms","breath alcohol content","2025-08-02",{"date":309,"type":39},"2025-08-06",{"date":311,"type":39},"2022-10-22",{"date":313,"type":20},"2027-09-01",{"name":45,"class":46},{"id":316,"slug":317,"hasResults":11,"nctId":318,"briefTitle":319,"officialTitle":319,"acronym":320,"eligibilityCriteria":321,"healthyVolunteers":56,"sex":16,"minAge":322,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":21,"phases":324,"briefSummary":325,"conditions":326,"keywords":330,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":342,"leadSponsor":344,"locationsCount":4},"100584066","lets-increase-fuerza-strength-through-exercise-and-diet-100584066","NCT06884501","Let's Increase Fuerza (Strength) Through Exercise and Diet","LIFTED","Inclusion Criteria:\n\n1\\) self-identify as a Latino\u002FHispanic, 2) age 50+, 3) documented cardiovascular disease (CVD) or at least one CVD risk factor (i.e., hypertension, hyperlipidemia, diabetes, obesity, current smoker, or family history of CVD), 3) participate in \\<3 days or \\<90 minutes of moderate-to-vigorous PA per week, 4) able to understand Spanish, 5) Wi-Fi Access, 6) score of greater than 21 on the TICS-M\n\nExclusion Criteria:\n\n1. uncontrolled illness including diabetes (e.g., participant reports high glucose levels despite treatment efforts), hypertension (e.g., participant is hypertensive while on medication or not adhering to medication), or thyroid disease (e.g., patient reports experiencing hyperthyroidism).\n2. history of musculoskeletal, cardiorespiratory, or neurological diseases that preclude the participation in moderate intensity exercise","50 Years",{"count":222,"type":20},[23],"The purpose of the study is to conduct a 6-month randomized controlled trial among Latinos ages 50+ at risk for cognitive decline and compare the efficacy of a remote-delivered, culturally tailored Latin dance program and strength training coupled with a Mediterranean-Dash Intervention for Neurodegenerative Delay (MIND) diet (IG) compared to a Latin dance and MIND diet program (CG) on cognitive performance, CVD risk factors, MIND diet adherence, physical activity, biomarkers, and psychosocial outcomes.\n\nParticipants will:\n\n* Randomly be placed in the intervention (IG) or control group (CG)\n* Have 2 pre and post intervention testing visits\n* Have weekly sessions during the 6-month trial",[327,328,329],"Older Adults (50-90 Years)","Cognition","Physical Activity",[331,332,333,334,335,336,337],"strength training","Latinos","Latin dance","physical activity","cognition","brain health","dietary pattern","2025-07-01",{"date":340,"type":39},"2025-07-04",{"date":41,"type":20},{"date":343,"type":20},"2026-09-01",{"name":45,"class":46},{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":349,"acronym":350,"eligibilityCriteria":351,"healthyVolunteers":56,"sex":16,"minAge":352,"maxAge":353,"enrollmentInfo":354,"targetDuration":4,"studyType":21,"phases":356,"briefSummary":357,"conditions":358,"keywords":363,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":365,"lastUpdatePostDateStruct":366,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":47},"100593835","integrated-childhood-activity-and-nutrition-ican-study-100593835","NCT07011602","INTEGRATED CHILDHOOD ACTIVITY AND NUTRITION (ICAN) STUDY","ICAN","Inclusion Criteria:\n\n* Parental\u002Fguardian consent\n* Child assent\n* Child participant is between the chronological age of 6-11 years.\n* Child participant is considered economically or educationally disadvantaged (e.g., eligible for Supplemental Nutritional Assistance Program \\[SNAP\\] and\u002For qualifies for free-and-reduced lunch.\n* Child participant must have 20\u002F20 or corrected 20\u002F20 vision.\n* Child participant absent of cognitive or neurological disorder (e.g., autism spectrum disorder)\n\nExclusion Criteria:\n\n* Parental\u002Fguardian does not provide consent\n* Child non-assent\n* Child participant chronological age when enrolling into the iCANS program falls below 6 or above 11 years of age\n* Child participant is not eligible for SNAP or does not qualify for free-and-reduced lunch.\n* Child participant does not have 20\u002F20 or corrected 20\u002F20 vision.\n* Presence of cognitive or neurological disorder (e.g., autism spectrum disorder)","6 Years","11 Years",{"count":355,"type":20},100,[23],"This study is a multi-functional integrated research and education project to prevent losses in academic achievement, cognitive function, and behavioral health among at-risk youth. The study tests the effects of a 8-week nutrition and physical activity-based program (Integrated Childhood Activity and Nutrition \\[ICAN\\]) to prevent summer learning loss. Outcomes include standardized academic achievement as well as executive function among 6-10-year-olds affected by poverty. The nutrition component of the intervention involves daily consumption of a snack containing the carotenoid lutein, typically found in high quantities in green leafy vegetables. The physical activity components will involve group games or activities.",[359,360,328,361,362],"Achievement","Weight Change","Fitness","Nutrition Status",[364],"brain, exercise, carotenoids, body composition","2025-06-05",{"date":367,"type":39},"2025-06-09",{"date":369,"type":39},"2025-06-04",{"date":371,"type":20},"2027-07-31",{"name":45,"class":46},{"id":374,"slug":375,"hasResults":11,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":379,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":16,"minAge":247,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":298,"phases":4,"briefSummary":384,"conditions":385,"keywords":387,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":392,"lastUpdatePostDateStruct":393,"startDateStruct":395,"completionDateStruct":397,"leadSponsor":399,"locationsCount":47},"100535895","alcohol-after-bariatric-surgery-2-100535895","NCT06257771","Alcohol After Bariatric Surgery 2","Pharmacokinetics and Responses to Alcohol After Bariatric Surgery","ABS2","Inclusion Criteria:\n\n* Surgery groups:\n\n  * Male and female, 21-64 yrs. of age\n  * Drink at least 1 standard drink per month but no more than 7 per week (women or \\> 14 for men)\n  * Underwent SG surgery 1-5 years ago\n\nNon-surgery control group\n\n* Male and female who did not undergo bariatric surgery\n* Age , BMI, race , and alcohol pattern of consumption equivalent to participants in the SG surgery groups\n\nExclusion Criteria:\n\n* For all groups (surgery and non-surgery groups)\n\n  * Smoking or having quit smoking less than 2 months ago\n  * Pregnant or breastfeeding\n  * Taking any medications that might affect alcohol metabolism\n  * Anemia\n  * Gastritis, colitis, Crohn's Disease, malabsorptive diseases, inflammatory diseases, liver disease, kidney disease, cancer less than five years ago, stroke, or severe organ dysfunction\n  * Body weight \\>450 pounds (because of a limit on body composition machine)\n  * Alcohol use disorder\n  * Regular use of drugs with addiction potential or regular misuse of substances\n  * Abnormality on EKG as determined by a study physician to present a safety risk","64 Years",{"count":383,"type":20},88,"The goal of this observational study is to learn how the body processes ingested alcohol and how alcohol affects mood and blood sugar in both men and women after undergoing sleeve gastrectomy. The main question\\[s\\]it aims to answer are:\n\n* Are there differences in the way that ingested alcohol is handled in men versus women after sleeve gastrectomy?\n* What is the consequence of drinking alcohol on an empty stomach versus after a meal on blood sugar control after undergoing sleeve gastrectomy?\n\nParticipants will participate in two types of alcohol tests (alcohol given orally or administered intravenously) after not eating anything overnight or after having a meal.\n\nResearchers will compare men and women who underwent sleeve gastrectomy with men and women who had no surgery, are of similar age and body composition, and have similar alcohol intake patterns.",[386],"Sleeve Gastrectomy",[388,389,390,391],"Alcohol metabolism","Bariatric surgery","Hypoglycemia","Metabolic surgery","2025-03-07",{"date":394,"type":39},"2025-03-11",{"date":396,"type":39},"2024-07-31",{"date":398,"type":20},"2028-08",{"name":45,"class":46},{"id":401,"slug":402,"hasResults":11,"nctId":403,"briefTitle":404,"officialTitle":405,"acronym":406,"eligibilityCriteria":407,"healthyVolunteers":56,"sex":16,"minAge":109,"maxAge":408,"enrollmentInfo":409,"targetDuration":4,"studyType":21,"phases":411,"briefSummary":412,"conditions":413,"keywords":415,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":423,"lastUpdatePostDateStruct":424,"startDateStruct":426,"completionDateStruct":428,"leadSponsor":430,"locationsCount":47},"100534760","breaking-sitting-with-high-intensity-interval-training-for-brain-health-100534760","NCT06243016","Breaking Sitting with High-intensity Interval Training for Brain Health","Breaking Prolonged Sitting with High-intensity Interval Training to Improve Cognitive and Brain Health in Older Adults: a Pilot Feasibility Trial.","HIIT2SITLess","Inclusion Criteria:\n\n1. Age 40-75 years\n2. BMI \\\u003C40 kg\u002Fm2\n3. Sedentary (≥ 6 h\u002Fday sitting by a survey question)\n4. Physically inactive adults based on the CSEP-PATH: Physical Activity and Sedentayr Behaviour Questionnaire (PASB-Q) Adult (low or medium physical activity range equivalent to less than 300 min of moderate intensity physical activity per week)\n5. Capable of exercising vigorously based on the Physical Activity Readiness Questionnaire (PARQ+)\n6. Has a medical clearance for maximal exercise and HIIT from a physician\n7. Normotensive or participant's blood pressure is controlled\n8. Intelligence quotient (IQ) ≥85\n9. Fasting plasma glucose \\\u003C126 mg\u002FdL\n10. Good or corrected vision and hearing\n11. Right-handed\n12. No significant abnormalities on the ECG during the maximal exercise test\n13. No signs and symptoms that suggest an underlying cardiovascular disease as recorded during the maximal exercise test by a study physician.\n14. No indications to prematurely stop the maximal exercise test as outlined by the ACSM's Guidelines for Exercise Testing and Prescription\n15. Concussion if more than 12 months before the study screening.\n16. History of cancer but in full remission for at least 12 months and no history of chemotherapy, signed off by the physician or an oncologist\n\nExclusion Criteria:\n\n1. Physical disability or musculoskeletal disease prohibitive to vigorous exercise\n2. Learning disabilities\n3. Cognitive impairment (MoCA \\\u003C26)\n4. Type 1 or 2 diabetes\n5. Neurological condition (e.g., Multiple Sclerosis, Parkinson, Dementia, Mild Cognitive Impairment)\n6. Color blindness\n7. Brain injury (e.g., traumatic brain injury, stroke, concussion)\n8. Migraine headaches\n9. Presence of other health conditions that may be exacerbated by exercise\n10. History of heart disease\n11. High cholesterol not controlled by medication\n12. Signs and symptoms indicative of underlying cardiovascular disease\n13. A chronic pulmonary disease\n14. Emphysema\n15. Pulmonary embolus\n16. Asthma\n17. History of renal disease\n18. History of seizures\n19. A neuropsychiatric disorder\n20. Osteoporosis if it interferes with an individual's ability to exercise\n21. Severe back problems\n22. Severe arthritis if it interferes with an individual's ability to exercise\n23. Thyroid disorder not controlled by medication\n24. Polyneuropathy\n25. Sleep disorders\n26. Acquired immunodeficiency syndrome (AIDS)\n27. Hepatitis C\n28. History of long Coronavirus Disease 2019 (COVID-19)\n29. History of cancer if not in full remission for at least 12 months and if a participant had the history of chemotherapy\n30. Current or past smoking \\\u003C12 months\n31. Corticosteroid intake \\\u003C 31 days before screening\n32. Opioids taken \\\u003C 6 months from screening\n33. Anabolic androgens taken \\\u003C 31 days before screening\n34. A serious illness or hospitalization in the last six months\n35. Currently taking medications that can affect the central nervous system (except for anxiolytics)\n36. Current participation in an ongoing trial likely to influence exercise ability or cognitive function","75 Years",{"count":410,"type":20},54,[23],"This trial will examine whether interrupting 3.5 hours of sitting every 30 min with 6 min high intensity interval training (HIIT) breaks compared to light intensity interval training (LIIT) will improve brain health in cognitively normal older adults. This trial will test the feasibility of HIIT breaks to sitting. It will also address several important but unanswered questions: (1) Does interrupting sitting with short HIIT breaks improve frontoparietal function? (2) Can interrupting sitting with HIIT breaks improve cognitive functions?",[414],"Aging",[416,417,418,419,420,421,422],"High-intensity interval training","Sitting","Executive functions","Inhibitory control","Episodic memory","Event-related potentials","Functional connectivity","2025-02-04",{"date":425,"type":39},"2025-02-07",{"date":427,"type":39},"2024-05-07",{"date":429,"type":20},"2025-07-31",{"name":45,"class":46},{"id":432,"slug":433,"hasResults":11,"nctId":434,"briefTitle":435,"officialTitle":436,"acronym":4,"eligibilityCriteria":437,"healthyVolunteers":56,"sex":16,"minAge":438,"maxAge":381,"enrollmentInfo":439,"targetDuration":4,"studyType":21,"phases":441,"briefSummary":442,"conditions":443,"keywords":447,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":451,"lastUpdatePostDateStruct":452,"startDateStruct":454,"completionDateStruct":456,"leadSponsor":458,"locationsCount":47},"100562648","optimized-tailored-interventions-in-metabolic-and-lifestyle-outcomes-optimal-100562648","NCT06605898","Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes (OPTIMAL)","Optimized Tailored Interventions in Metabolic and Lifestyle Outcomes: Examining the Effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay(MIND) on Cognitive Performance, Metabolic Health and Lifestyle Outcomes Using Advanced Machine Learning Strategies","Inclusion Criteria:\n\n* 45-64 years of age\n* 20\u002F20 or corrected vision\n* No food allergies or intolerances\n* Not pregnant, lactating, or have given birth in the past 12 months\n* Do not smoke, use tobacco, or abuse drugs\n* Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer\n* Not currently taking oral hypoglycemic agents, or insulin\n* No history of malabsorptive or bariatric surgery\n* Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Able to consume the study meals\n* Not enrolled in another dietary, exercise, or medication study during the study.\n\nExclusion Criteria:\n\n* Non-consent of participant\n* Above 64 or below 45 years of age\n* Vision not 20\u002F20 or corrected\n* Food allergies or intolerances\n* Pregnant, lactating, or have given birth in the past 12 months\n* Smoke, use tobacco, or abuse drugs\n* Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer\n* Currently taking oral hypoglycemic agents or insulin\n* History of malabsorptive or bariatric surgery\n* Cognitively impaired and\u002For prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Unable to consume the study meals\n* Concurrent enrollment in another dietary, exercise, or medication study","45 Years",{"count":440,"type":20},72,[23],"The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults. Our research team will evaluate three different groups: the first group will be chosen using a predictive analytics model that predicts who will benefit most from the MIND diet, the second group will follow the MIND diet without being pre-selected, and the third group will eat a standard healthy diet to serve as a comparison.\n\nThe main questions it aims to answer are:\n\nDoes the MIND diet improve cognitive performance and heart health relative to a control diet? How does the health impact of the MIND diet in participants pre-identified through predictive analytics compare to those without such pre-selection? Which of the three groups - predictive analytics selected MIND diet group, standard MIND diet group, or healthy control - demonstrate the most significant improvements in cognitive and cardiovascular health over the course of the trial?\n\nParticipants will:\n\nConsume one meal that follows the MIND diet or a control meal every day for 3 months. Visit the lab before and after the 3 months of meals for tests. Keep a record of the food they eat during the study.",[444,445,446],"Cognitive Change","Diet, Healthy","Metabolic Syndrome, Protection Against",[448,449,450],"Executive function","MIND","Dietary Pattern","2024-09-18",{"date":453,"type":39},"2024-09-20",{"date":455,"type":39},"2024-07-03",{"date":457,"type":20},"2027-12-31",{"name":45,"class":46},{"id":460,"slug":461,"hasResults":11,"nctId":462,"briefTitle":463,"officialTitle":463,"acronym":464,"eligibilityCriteria":465,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":381,"enrollmentInfo":466,"targetDuration":4,"studyType":21,"phases":468,"briefSummary":469,"conditions":470,"keywords":472,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":475,"lastUpdatePostDateStruct":476,"startDateStruct":478,"completionDateStruct":480,"leadSponsor":481,"locationsCount":47},"100550738","remote-evaluation-of-mind-diet-100550738","NCT06450977","Remote Evaluation of MIND Diet","REMIND","Inclusion Criteria:\n\n1. Individuals aged 18-64 years old\n2. Self-reported diagnosis of Multiple sclerosis (MS)\n3. 20\u002F20 or corrected vision\n4. No other neurodegenerative disease diagnosis\n5. Stable disease-modifying therapy (DMT) within 6 months\n6. Not Pregnant or lactating\n7. No food allergies or intolerances\n8. Able to consume study meals\n9. Not enrolled in another dietary, exercise, or medication study during the study\n10. Access to a computer\u002Flaptop with internet\n\nExclusion Criteria:\n\n1. Individuals younger than 18 or older than 64 years old\n2. No self-reported diagnosis of Multiple sclerosis (MS)\n3. Not 20\u002F20 or uncorrected vision\n4. Other neurodegenerative disease diagnosis\n5. Disease modifying therapy (DMT) less than 6 months\n6. Pregnant or lactating\n7. Food allergies or intolerances\n8. Not able to consume study meals\n9. Enrolled in another dietary, exercise, or medication study during the study\n10. No access to a computer\u002Flaptop with internet",{"count":467,"type":20},40,[23],"The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is:\n\nDoes the MIND diet improve cognitive performance relative to a control diet in persons with MS?\n\nParticipants will:\n\nConsume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.",[27,444,471],"Nutrition, Healthy",[473,449,450,474],"Executive Function","Telehealth","2024-06-25",{"date":477,"type":39},"2024-06-27",{"date":479,"type":39},"2024-06-07",{"date":73,"type":20},{"name":45,"class":46},{"id":483,"slug":484,"hasResults":11,"nctId":485,"briefTitle":486,"officialTitle":487,"acronym":4,"eligibilityCriteria":488,"healthyVolunteers":56,"sex":16,"minAge":438,"maxAge":381,"enrollmentInfo":489,"targetDuration":4,"studyType":21,"phases":490,"briefSummary":491,"conditions":492,"keywords":493,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":495,"lastUpdatePostDateStruct":496,"startDateStruct":498,"completionDateStruct":500,"leadSponsor":501,"locationsCount":4},"100549732","nutritional-intervention-for-sustaining-health-nurish-trial-100549732","NCT06437860","Nutritional Intervention for Sustaining Health (NURISH) Trial","Nutritional Intervention for Sustaining Health (NURISH) Trial: Examining the Effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) on Cognitive Performance, Metabolic Health, and Nutrient Status.","Inclusion Criteria:\n\n* 45-64 years of age\n* 20\u002F20 or corrected vision\n* No food allergies or intolerances\n* Not pregnant, lactating, or have given birth in the past 12 months\n* Do not smoke, use tobacco, or abuse drugs\n* Absence of liver or gastrointestinal diseases (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, and cancer\n* Not currently taking oral hypoglycemic agents, or insulin\n* No history of malabsorptive or bariatric surgery\n* Cognitively intact with no prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Able to consume the study meals\n* Not enrolled in another dietary, exercise, or medication study during the study\n\nExclusion Criteria:\n\n* Non-consent of participant\n* Above 64 or below 45 years of age\n* Vision not 20\u002F20 or corrected\n* Food allergies or intolerances\n* Pregnant, lactating, or have given birth in the past 12 months\n* Smoke, use tobacco, or abuse drugs\n* Prior diagnosis of liver or gastrointestinal disease (i.e., primary biliary cirrhosis or gallbladder disease, chronic constipation, diarrhea, Crohn's disease, celiac disease, ulcerative colitis, irritable bowel syndrome, diverticulosis, stomach or duodenal ulcers), hepatitis, HIV, or cancer\n* Currently taking oral hypoglycemic agents or insulin\n* History of malabsorptive or bariatric surgery\n* Cognitively impaired and\u002For prior diagnosis of neurological disease (i.e., mild cognitive impairment, Alzheimer's disease, vascular dementia, and\u002For Asperger's syndrome)\n* Unable to consume the study meals\n* Concurrent enrollment in another dietary, exercise, or medication study",{"count":440,"type":20},[23],"The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves brain and heart health relative to a healthy control diet in middle-aged adults.The main questions it aims to answer are:\n\nDoes the MIND diet improve cognitive performance and heart health relative to a control diet?\n\nResearchers will compare the MIND diet group to a control (a healthy diet that does not match the MIND diet) to see if the MIND provides more benefit to health.\n\nParticipants will:\n\nConsume one meal that follows the MIND diet or a control meal every day for 3 months Visit the lab before and after the 3 months of meals for tests. Keep a record of the food they eat during the study.",[444,446,445],[448,449,494],"Dietary pattern","2024-05-24",{"date":497,"type":39},"2024-05-31",{"date":499,"type":20},"2024-06-03",{"date":457,"type":20},{"name":45,"class":46},{"id":503,"slug":504,"hasResults":11,"nctId":505,"briefTitle":506,"officialTitle":507,"acronym":508,"eligibilityCriteria":509,"healthyVolunteers":56,"sex":16,"minAge":144,"maxAge":353,"enrollmentInfo":510,"targetDuration":4,"studyType":21,"phases":512,"briefSummary":513,"conditions":514,"keywords":516,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":522,"lastUpdatePostDateStruct":523,"startDateStruct":525,"completionDateStruct":527,"leadSponsor":529,"locationsCount":47},"100537330","plants-optimizing-development-study-pods-100537330","NCT06276426","Plants Optimizing Development Study (PODS)","Plants Optimizing Development Study","PODS","Inclusion Criteria:\n\n* Child assent and parent\u002Fguardian consent\n* Free of any food allergy\n* 8-11 years of age\n* Tanner scale score of ≤ 2\n* 20\u002F20 or corrected vision\n* No antibiotic usage in the past 3 months\n* ≤1 serving\u002Fd of soy food habitual consumption\n\nExclusion Criteria:\n\n* Non-assent or consent by child assent and\u002For parent\u002Fguardian\n* Presence of any food allergy\n* Younger than 8 years or older than 11 years\n* Presence of specific neurological and genetic disorders (i.e., Autism, Cerebral Palsy, Multiple Sclerosis, Down syndrome)\n* Presence of endocrine, metabolic, and gastrointestinal disease e.g., hypertension, diabetes, celiac disease\n* Tanner scale score of \\> 2\n* Not 20\u002F20 or uncorrected vision\n* Antibiotic usage in the past 3 months\n* \\>1 serving\u002Fd of soy food habitual consumption",{"count":511,"type":20},96,[23],"This study aims to conduct a randomized clinical trial to measure the effects of a 3-month daily mixed-soy food intervention vs. a control group receiving isocaloric foods on reproductive hormones, body composition, metabolic risk, fecal microbiota, and cognition among 8-11-year-old children. Additionally, this study will assess soy food intake immediately following participation in the clinical trial to determine changes in soy food acceptance in children.",[515],"Healthy Children",[517,518,335,519,520,521],"soy","isoflavones","body composition","fecal microbiota","metabolic risk","2024-04-16",{"date":524,"type":39},"2024-04-17",{"date":526,"type":39},"2024-03-18",{"date":528,"type":20},"2026-09-30",{"name":45,"class":46},{"id":531,"slug":532,"hasResults":11,"nctId":533,"briefTitle":534,"officialTitle":535,"acronym":4,"eligibilityCriteria":536,"healthyVolunteers":56,"sex":16,"minAge":17,"maxAge":537,"enrollmentInfo":538,"targetDuration":4,"studyType":21,"phases":540,"briefSummary":541,"conditions":542,"keywords":4,"overallStatus":178,"whyStopped":4,"lastUpdateSubmitDate":544,"lastUpdatePostDateStruct":545,"startDateStruct":547,"completionDateStruct":549,"leadSponsor":551,"locationsCount":47},"100484684","strong-couples-project-disseminating-evidence-based-relationship-education-100484684","NCT05591261","Strong Couples Project: Disseminating Evidence-based Relationship Education","Strong Couples Project: ePREP Nationwide Dissemination","Inclusion Criteria:\n\n* Resident of Illinois\n* Married, engaged, or living with their partner for at least 6 months\n* Both partners willing to participate in online relationship-focused programming\n\nExclusion Criteria:\n\n* One or both partners reports sever forms of intimate partner violence occurring in the relationship","120 Years",{"count":539,"type":20},500,[23],"The current research is designed to implement and evaluate the ePREP relationship intervention with couples via the Cooperative Extension system.",[177,543],"Relational Problems","2022-10-19",{"date":546,"type":39},"2022-10-24",{"date":548,"type":20},"2022-10",{"date":550,"type":20},"2027-09",{"name":45,"class":46},""]