[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Jordan\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":347},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,48,86,108,129,157,187,216,243,268,295,320],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100561262","phase-4-the-effect-of-different-types-of-mouthwash-on-extraction-sockets-healing-100561262",false,"NCT06587880","The Effect of Different Types of Mouthwash on Extraction Sockets' Healing","A Randomized Controlled Trial on the Effect of Different Types of Mouthwash on the Healing of Extraction Sockets","Inclusion Criteria:\n\n* Male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar that is indicated for extraction with bone removal and the presence of an adjacent second molar.\n\nExclusion Criteria:\n\n* Soft tissue impaction that will not need any bone removal.\n* Presence of any acute oral infection including active Pericoronitis.\n* Patients who have undergone radiotherapy in the head and neck region, chemotherapy or systemic long-term corticosteroid treatment.\n* Patients receiving medications known to induce gingival hyperplasia; anticonvulsant (phenytoin), immunosuppressant (cyclosporine A), and various calcium channel blockers (nifedipine, verapamil, diltiazem).\n* Patients who have taken systemic antibiotics less than 3 months prior to baseline.\n* Presence of uncontrolled diabetes, severe nutritional deficiencies and endocrine disturbances.\n* Presence of immune deficiency or any immune disease.\n* Intravenous bisphosphonates or Oral bisphosphonate intake for more than 3 years.\n* Smokers and alcoholics.\n* Pregnant or lactating females.\n* Hypersensitivity to one of the ingredients listed in any of the mouthwashes, especially chlorhexidine as reactions to this has been reported in the literature.","ALL","18 Years",{"count":19,"type":20},100,"ESTIMATED","INTERVENTIONAL",[23],"PHASE4","The goal of this clinical trial is to assess the effect of four different types of mouthwash on socket healing after surgical extractions in male or female patients aged 18 years and older who have a unilateral impacted mandibular third molar indicated for extraction. The main questions it aims to answer are:\n\nThe effect of Bone Bioactive Liquid (BBL) mouthwash, Hyaluronic Acid (HA) mouthwash, the Chlorhexidine digluconate (CHX) mouthwash and Warm Saline Mouth Rinse (WSMR) on socket healing after surgical extractions.\n\nThe effect of BBL mouthwash, HA mouthwash, the CHX mouthwash and WSMR on patient related factors and their quality of life.\n\nRecruited Participants will be randomized into four intervention groups:\n\n1. First group will receive BBL mouthwash.\n2. The second group will receive CHX mouthwash.\n3. The third group will be prescribed HA mouthwash.\n4. The fourth group will receive Warm Saline Mouth Rinse.",[26,27,28],"Extraction Socket Healing","Quality of Life","Postoperative Complications",[30,31,32,33,34],"Clinical trial","Mouthwash","Socket healing","Postoperative complications","Quality of life","RECRUITING","2026-05-03",{"date":38,"type":39},"2026-05-07","ACTUAL",{"date":41,"type":39},"2025-08-10",{"date":43,"type":20},"2026-12",{"name":45,"class":46},"University of Jordan","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":16,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":21,"phases":60,"briefSummary":62,"conditions":63,"keywords":68,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":4},"100636711","patient-reported-outcomes-of-four-intraoral-suture-materials-100636711","NCT07569237","Patient-Reported Outcomes of Four Intraoral Suture Materials","Patient-Reported Outcomes Following Application of Intraoral Sutures: A Split-Mouth Randomized Controlled Trial","Inclusion Criteria:\n\nAdults aged 20-30 years.\n\nSystemically healthy (ASA I-II).\n\nNo history of allergy to study suture materials.\n\nPeriodontally healthy, with no active oral lesions, including carious lesions.\n\nDental Requirements: All maxillary canine, second premolar, and first molar teeth present.\n\nMinimal (≤0.5 mm) open contacts between the pairs of teeth that define the study sites.\n\nIdeally, full maxillary dentition present from first molar to first molar.\n\nAt least 2 mm of keratinized tissue width on buccal intervention sites.\n\nWilling and able to provide informed consent.\n\nWilling and able to attend all study follow-up visits and complete study questionnaires.\n\nExclusion Criteria:\n\nAllergy to any study materials (e.g., suture materials or anesthetics) or medications (Paracetamol).\n\nAny systemic disease affecting wound healing (e.g., diabetes, immunosuppression).\n\nUse of any medications.\n\nPregnancy or lactation.\n\nUnwillingness or inability to provide informed consent.\n\nUnwillingness or inability to comply with study protocol and follow-up visits.\n\nExit Criteria:\n\nParticipants may exit the study at any time if they wish to discontinue participation.\n\nNoncompliance with study protocol and visits.\n\nDevelopment of conditions (e.g., infection) that require immediate care or that introduce exclusion criteria.",true,"20 Years","30 Years",{"count":59,"type":20},60,[61],"NA","When patients undergo minor oral surgery, dentists use various types of stitches (sutures) to help the gums heal. These stitches can be made of different materials, and some might feel more comfortable, cause less pain, or interfere less with eating and speaking than others.\n\nThe purpose of this study is to compare four commonly used dental suture materials to see which ones patients prefer. Participants in this study will receive four different types of stitches in different areas of their upper jaw after a routine dental procedure.\n\nPatients will be asked to report their levels of pain, discomfort, and any difficulties with daily activities like eating and talking on Days 3, 7, and 14 after the procedure. A panel of dental specialists will also examine photos of the healing process to see if one material helps the mouth heal better than others. This research will help dentists choose the best materials to improve patient comfort after oral surgery.",[64,65,66,67],"Suture Materials","Wound Healing","Patient Comfort","Oral Health-Related Quality of Life",[69,70,71,72,73,74,75,76],"Split-mouth design","Patient-reported outcome measures (PROMs)","Intraoral sutures","Dental surgery","Visual Analog Scale (VAS)","Periodontology","Oral surgery healing","Braided vs Monofilament sutures","NOT_YET_RECRUITING","2026-04-28",{"date":80,"type":39},"2026-05-06",{"date":82,"type":20},"2026-07",{"date":84,"type":20},"2028-04",{"name":45,"class":46},{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":4,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":21,"phases":95,"briefSummary":96,"conditions":97,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":105,"leadSponsor":107,"locationsCount":47},"100616792","evaluation-of-postoperative-pain-and-success-rate-between-lateral-condensation-and-warm-vertical-obturation-techniques-100616792","NCT07310212","Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques","Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques - A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients requiring endodontic treatment for single-rooted necrotic teeth.\n* Radiographic and clinical diagnosis of asymptomatic apical periodontitis.\n* Ability to understand the study and provide written informed consent.\n\nExclusion Criteria:\n\n* Teeth diagnosed with symptomatic apical periodontitis.\n* Pregnant or lactating women.\n* Patients with systemic diseases affecting pain perception (e.g., uncontrolled diabetes, chronic pain conditions).\n* Teeth that have been previously endodontically treated.\n* Patients taking medications that may influence pain perception (e.g., chronic analgesic or anti-inflammatory drug use).\n* Periodontally compromised teeth with significant bone loss or mobility.",{"count":94,"type":20},80,[61],"Brief Summary\n\nPostoperative pain is a common complication following root canal treatment, particularly in necrotic teeth with asymptomatic apical periodontitis. Although obturation technique has been suggested as a contributing factor to postoperative discomfort, direct clinical comparisons between commonly used methods remain limited. Cold lateral condensation has traditionally been considered the standard obturation technique, while warm vertical obturation systems such as Obtura II have gained popularity due to their potential for improved adaptation of gutta-percha.\n\nThis randomized controlled clinical trial aims to compare postoperative pain experience and treatment outcomes following cold lateral condensation and warm vertical obturation in single-rooted necrotic teeth. Postoperative pain will be assessed during the early healing period, along with patient-reported outcomes and short-term clinical and radiographic healing. The results of this study are expected to provide clinically relevant evidence to support evidence-based obturation technique selection and improve patient comfort in endodontic practice.",[98,99],"Necrotic Pulp","Asymptomatic Apical Periodontitis","2026-03-27",{"date":102,"type":39},"2026-04-02",{"date":104,"type":39},"2024-10-17",{"date":106,"type":20},"2026-12-01",{"name":45,"class":46},{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":4,"eligibilityCriteria":114,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":115,"enrollmentInfo":116,"targetDuration":4,"studyType":21,"phases":117,"briefSummary":118,"conditions":119,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":124,"completionDateStruct":126,"leadSponsor":128,"locationsCount":47},"100591175","influence-of-occlusal-reduction-on-endodontic-postoperative-pain-100591175","NCT06977009","Influence of Occlusal Reduction on Endodontic Postoperative Pain","Influence of Occlusal Reduction on Endodontic Postoperative Pain: a Randomized Clinical Trial","Inclusion Criteria:\n\n1. Systemically healthy subjects (ASA I\\&II) between the age of 18 and 70 years\n2. Patients diagnosed with necrotic pulp or previously initiated (accessed).\n3. Posterior maxillary or mandibular molar tooth.\n4. Presence of an opposing tooth (or teeth) with normal occlusal contact with the opposing tooth (or teeth).\n5. Tooth needs cuspal coverage.\n\nExclusion Criteria:\n\n1. Pregnant females.\n2. Patients with significant medical conditions (ASA III \\& IV).\n3. Reported bruxism or clenching.\n4. Took analgesics\\\\antibiotics or other drugs that might alter their pain during the last 12 hours preoperatively.\n5. A history of allergic reactions to any of the medications and\u002For materials used.\n6. Patients with a tooth that had no contacts or premature contact, fewer than three teeth on one side of the jaw.\n7. Greater than grade I mobility or pocket depth greater than 5mm.\n8. Non-restorable crowns, severely curved root canals, or post-treatment endodontic disease were, also, excluded.","70 Years",{"count":59,"type":20},[61],"This study aims to assess the impact of occlusal reduction on post-operative pain after single-visit root canal treatment in patients with necrotic pulps or previously initiated (accessed).",[120],"Post Operative Pain Management","2025-05-10",{"date":123,"type":39},"2025-05-16",{"date":125,"type":39},"2025-02-28",{"date":127,"type":20},"2025-07-20",{"name":45,"class":46},{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":134,"acronym":4,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":16,"minAge":136,"maxAge":137,"enrollmentInfo":138,"targetDuration":4,"studyType":21,"phases":140,"briefSummary":142,"conditions":143,"keywords":145,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":47},"100588141","phase-1-use-of-extracellular-vesicles-ev-for-knee-osteoarthrosis-100588141","NCT06937528","Use of Extracellular Vesicles (EV) for Knee Osteoarthrosis","Knee Osteoarthrosis (KOA) in Jordanian Patients: a Phase I Dose-finding Study Using Extracellular Vesicles (EV) for Advanced Stage III and IV KOA","Inclusion Criteria:\n\n* Severe KOA stage III or IV by Laurance \\& Kellgren staging as judged by Posterioranterior (PA) Xray of the knee joint.\n* Willing to participate by signing the informed consent\n\nExclusion Criteria:\n\n* Sublaxation beyond 20 degrees of the bones of the knee joint\n* Oral anticoagulants or heparin therapy\n* Heart failure or arrhythmia\n* Body Mass Index \\> 35\n* Uncontrolled Diabetes Mellitus.\n* Evidence of Infectious Diseases.\n* Active infection\n* Malignancy\n* Pregnancy\n* Anemia less than 11g\u002Fdl or thrombocytopenia less than 100,000 or leucopenia less than 3000.\n* Unreliable patients\n* Non-resident in Jordan","42 Years","75 Years",{"count":139,"type":20},50,[141],"PHASE1","Extracellular vesicles (EV) will be injected in patients diagnosed with Knee osteoarthrosis",[144],"Knee Osteoarthrosis",[146,147,148],"osteoarthrosis","Knee","Extracellular vesicles","2025-04-13",{"date":151,"type":39},"2025-04-22",{"date":153,"type":39},"2024-01-01",{"date":155,"type":20},"2027-01-30",{"name":45,"class":46},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":21,"phases":167,"briefSummary":168,"conditions":169,"keywords":175,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":186,"locationsCount":47},"100586172","the-effect-of-time-restricted-eating-on-glycemic-and-proinflammatory-biomarkers-among-prediabetic-obese-jordanian-adults-aged-18-40-years-old-100586172","NCT06911918","The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old","The Effect of Time Restricted Eating on Glycemic and Proinflammatory Biomarkers Among Prediabetic Obese Jordanian Adults Aged 18-40 Years Old: A Randomized Control Study","Inclusion Criteria:\n\n* IR individuals diagnosed with IR by the physicians as indicated by HOMA-IR score\n* female and male, BMI ≥ 30 to 39.9 kg\u002Fm2\n* age between 18 and 40 years\n* stable weight for 3 months before the beginning of the study\n* sedentary lifestyle\n\nExclusion Criteria:\n\n* previous weight loss surgery\n* pregnancy or intent to become pregnant\n* breastfeeding\n* chronic diseases\n* drug therapies that could interfere with the effectiveness of the dietary intervention (e.g., use of corticosteroids, and anti-diabetic drugs)\n* diabetic type 1 and 2 individuals\n* anyone physically active to reduce the influence of confounding covariates","40 Years",{"count":166,"type":20},120,[61],"Obesity, a global epidemic, significantly contributes to prediabetes, cardiovascular diseases, and other chronic diseases due to its pro-inflammatory nature. This studyl investigates the effects of time-restricted eating (TRE) with calorie restriction (CR), TRE without CR, and CR without TRE on glycemic control and pro-inflammatory biomarkers among prediabetic obese Jordanian adults aged 18-40 years. The study assesses changes in pro-inflammatory biomarkers (IL-1β, TNF-α, IL-6), insulin resistance (HOMA-IR), and body composition over 12 weeks.\n\nParticipants (n=120) will be randomized into four intervention arms: (1) TRE with CR, (2) TRE without CR, (3) CR without TRE, and (4) a control group with no dietary restrictions and no TRE. Biweekly anthropometric assessments will evaluate pro-inflammatory biomarkers and biochemical measures at baseline and the end of the study. The findings will provide insights into the comparative effectiveness of TRE and CR, potentially offering a safe, cost-effective intervention to prevent obesity-induced inflammation, prediabetes, and progression to type 2 diabetes mellitus.",[170,171,172,173,174],"Insulin Resistance","Inflammation Biomarkers","Time Restricted Eating","Caloric Restriction","Obesity (Disorder)",[176,170,177,173,178],"Time restricted eating","Obesity","Inflammation cytokines","2025-03-27",{"date":181,"type":39},"2025-04-04",{"date":183,"type":20},"2025-04-05",{"date":185,"type":20},"2025-11",{"name":45,"class":46},{"id":188,"slug":189,"hasResults":11,"nctId":190,"briefTitle":191,"officialTitle":192,"acronym":4,"eligibilityCriteria":193,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":21,"phases":197,"briefSummary":198,"conditions":199,"keywords":202,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":208,"lastUpdatePostDateStruct":209,"startDateStruct":211,"completionDateStruct":213,"leadSponsor":215,"locationsCount":47},"100548179","prosthetic-outcomes-and-clinical-performance-of-implant-supported-zirconia-crowns-100548179","NCT06417632","Prosthetic Outcomes and Clinical Performance of Implant Supported Zirconia Crowns","Prosthetic Outcomes and Clinical Performance of Two Types of Monolithic Zirconia-based Screw-retained Crowns. A Randomized Clinical Trial","Inclusion Criteria:\n\n* Partially edentulous area with suitable restorative space more than 5.5 mm\n* At least 18 years of age\n* Opposing natural teeth or fixed restorations supported by teeth or implants.\n* Generally good health (ASA I, ASA II)\n* Participant complies with good oral hygiene practices (BOP and PI less than 20%)\n* Healthy integrated implant\u002Fs without signs of periimplantitis in the posterior site planned for single tooth replacement (in premolar or molar areas)\n* Patients received bone-level implants, RC Straumann Implants.\n\nExclusion Criteria:\n\n* Inability to provide consent.\n* Temporomandibular disorders\n* Smoking of more than 10 cigarettes per day\n* Untreated caries or periodontal disease of remaining dentition","60 Years",{"count":196,"type":20},40,[61],"To compare biological, technical, radiographic, and patient-reported outcomes of two types of monolithic zirconia crowns screw-retained to implant.\n\nTo assess whether the new form of multilayered zirconia crowns will show similar survival and success rate to conventional monolithic Zirconia screw-retained to implants in molar and premolar regions.\n\nFirst Null Hypothesis: Multilayered monolithic zirconia crowns would have similar survival, success rate compared to conventional monolithic zirconia implant supported crowns.\n\nSecond Null hypothesis: There would be no difference in clinical and patients related outcomes between multilayered and conventional monolithic zirconia implant supported crowns.",[200,201],"Dental Restoration","Dental Implant",[203,204,205,206,207],"implant-supported","patient-reported outcome,","technical, biological outcomes","survival\u002Fsuccess rate","single-tooth restorations","2025-03-26",{"date":210,"type":39},"2025-04-01",{"date":212,"type":20},"2025-08",{"date":214,"type":20},"2026-11",{"name":45,"class":46},{"id":217,"slug":218,"hasResults":11,"nctId":219,"briefTitle":220,"officialTitle":221,"acronym":4,"eligibilityCriteria":222,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":115,"enrollmentInfo":223,"targetDuration":4,"studyType":21,"phases":224,"briefSummary":226,"conditions":227,"keywords":230,"overallStatus":77,"whyStopped":4,"lastUpdateSubmitDate":236,"lastUpdatePostDateStruct":237,"startDateStruct":238,"completionDateStruct":240,"leadSponsor":242,"locationsCount":4},"100584800","early-phase-1-intracanal-dexamethasone-extrusion-and-postoperative-endodontic-pain-100584800","NCT06894069","Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain","Effect of Intentional Extrusion of an Intracanal Corticosteroid Solution on Post Endodontic Treatment Pain: a Randomized Clinical Trial","Inclusion Criteria:\n\n* A diagnosis of irreversible pulpits with symptomatic apical periodontitis\n* Adult patients (aged 18 - 70)\n* Healthy patients or those with a well-controlled disease (ASA I \\& II)\n\nExclusion Criteria:\n\n* A diagnosis of necrotic pulp, or normal apical tissues\n* Patients with a severe systemic disease (ASA III or higher)\n* Patients who received analgesics12 hours before presentation\n* Previously treated\u002Finitiated Endodontics treatment on the same tooth\n* Unopposed teeth\n* Third molar teeth\n* Non-restorable teeth\n* Periodontally compromised teeth\n* Pregnant or lactating patients",{"count":94,"type":20},[225],"EARLY_PHASE1","The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic irreversible pulpitis and symptomatic apical periodontitis (SIP\u002FSAP). The main question it aims to answer: Is there an analgesic effect of extruding an intracanal solution of DXA into the periapical tissues in patients diagnosed with SIP\u002FSAP? Researchers will compare dexamethasone to a placebo to see if the extrusion dexamethasone works in reducing post-endodontic treatment pain.",[228,229],"Post Operative Pain Control","Endodontic Treatment",[231,232,233,234,235],"Root canal treatment","Post-operative pain","Corticosteroids","Dexamethasone","Randomised controlled trial","2025-03-25",{"date":208,"type":39},{"date":239,"type":20},"2025-03",{"date":241,"type":20},"2025-05",{"name":45,"class":46},{"id":244,"slug":245,"hasResults":11,"nctId":246,"briefTitle":247,"officialTitle":247,"acronym":4,"eligibilityCriteria":248,"healthyVolunteers":11,"sex":16,"minAge":249,"maxAge":250,"enrollmentInfo":251,"targetDuration":4,"studyType":21,"phases":253,"briefSummary":254,"conditions":255,"keywords":257,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":260,"lastUpdatePostDateStruct":261,"startDateStruct":263,"completionDateStruct":265,"leadSponsor":267,"locationsCount":47},"100538677","phase-1-allogeneic-wharton-jelly-mesenchymal-stromal-cell-wjmsc-for-treatment-of-autism-100538677","NCT06293950","Allogeneic Wharton Jelly Mesenchymal Stromal Cell (WJMSC) for Treatment of Autism","Inclusion Criteria:\n\n* 14 subjects, 4-14 years of age, will be enrolled into this study, who meet the criteria for (ASD\n\nExclusion Criteria:\n\n* Age \\> 14 years.\n* Patient weighing \\\u003C 10 kg.\n* History of severe Allergy\n* History of severe head trauma, defined by loss of consciousness or hospitalization, skull fracture, or stroke.\n* Seizure within the last year before enrollment, or the need for seizure medications either at present or in the past.\n* Evidence or history of severe, moderate, or uncontrolled systemic disease.\n* Inability to follow the prescribed dosing and follow-up schedule.\n* Use of any stimulant or non-stimulant medication or medications given for attention deficit hyperactivity disorder (ADHD) must be discontinued 7 days before the initial randomized study period.\n* Subjects taking a selective serotonin reuptake inhibitor (SSRI) must be on a stable dose for a minimum of 30 days before entering the study.\n* History of premature birth \\\u003C35 weeks' gestation.\n* Prior history of stroke in utero or other in utero insult.","4 Years","14 Years",{"count":252,"type":20},14,[141],"Autism spectrum disorders (ASDs) are characterized by core domains: persistent deficits in social communication and interaction; restricted, repetitive patterns of behavior, interests, or activities.",[256],"Autism",[258,259],"autism","WJMSC","2025-01-23",{"date":262,"type":39},"2025-01-24",{"date":264,"type":39},"2022-03-09",{"date":266,"type":20},"2027-12",{"name":45,"class":46},{"id":269,"slug":270,"hasResults":11,"nctId":271,"briefTitle":272,"officialTitle":273,"acronym":4,"eligibilityCriteria":274,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":275,"targetDuration":4,"studyType":21,"phases":277,"briefSummary":278,"conditions":279,"keywords":280,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":47},"100571090","comparison-of-abutments-engagement-configurations-in-implant-supported-fixed-partial-dentures-100571090","NCT06715722","Comparison of Abutments Engagement Configurations in Implant Supported Fixed Partial Dentures","Comparison of Abutments Engagement Configurations in Implant Supported Fixed Partial Dentures: a Randomized Clinical Trial","Inclusion Criteria:\n\n* Adult patients with edentulous span in the posterior mandible of 3 missing teeth.\n* Candidates for an implant supported FDP in the posterior mandible.\n* Teeth in area of interest extracted at least 3 months prior.\n* Bone grafting not needed or only minor GBR needed.\n* Controlled oral hygiene.\n* Sufficient bone volume.\n\nExclusion Criteria:\n\n* Patients with edentulous span of less than 3 missing teeth (not eligible to receive a 3 unit 2 implant supported FDP)\n* Patients with healing period of extraction sites less than 3 months.\n* Extensive bone grafting required prior to or during implant placement.\n* Active Bruxism.\n* Heavy smoker (\\> 10 cigarettes).\n* Systemic diseases that might affect bone healing.\n* Patients who are not willing or unable to give consent.",{"count":276,"type":20},24,[61],"This study focuses on the comparison of different implant abutment connections configurations in implant supported screw retained fixed dental prostheses assessing their clinical and radiographic outcomes and to evaluate which implant abutment connection configuration have less biological and technical complications.",[201],[281,282,283,284,285,286],"Implant abutment connection","Dental implant","Fixed dental prosthesis","Engaging abutment","Non-engaging abutment","Conical connections","2024-11-28",{"date":289,"type":39},"2024-12-04",{"date":291,"type":39},"2024-11-11",{"date":293,"type":20},"2025-11-10",{"name":45,"class":46},{"id":296,"slug":297,"hasResults":11,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":55,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":302,"targetDuration":4,"studyType":21,"phases":303,"briefSummary":304,"conditions":305,"keywords":306,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":312,"lastUpdatePostDateStruct":313,"startDateStruct":315,"completionDateStruct":317,"leadSponsor":319,"locationsCount":47},"100569365","immediate-versus-conventional-loading-of-early-placed-dental-implant-supporting-single-crowns-100569365","NCT06693297","Immediate Versus Conventional Loading of Early Placed Dental Implant Supporting Single Crowns","Immediate Versus Conventional Loading of Early Placed Dental Implant Supporting Single Crowns: a Randomized Controlled Trial","Inclusion Criteria:\n\n1. aged 18 years or older\n2. requiring single tooth replacement with dental implants in presence of four bone walls (mandible or maxilla)\n3. having adequate bone volume\n4. controlled oral hygiene\n5. having agreed to take part in the study and willing to comply with the study protocol and follow-up visits\n\nExclusion Criteria:\n\n1. Any systemic condition that might jeopardize implant surgery\n2. history of radiation therapy to the head and neck region\n3. history of bisphosphonate therapy or other medications that may affect bone metabolism\n4. smoking more than 10 cigarettes\u002Fday\n5. history of bruxism or parafunctional habits\n6. localized\u002Fgeneralized periodontitis\n7. patients in need of bone grafting\n8. any known allergy or hypersensitivity to implant materials",{"count":196,"type":20},[61],"This study focuses on examining the efficacy and clinical performance of immediate loading of early placed single implants.\n\nThe aim of the randomized controlled trial is to compare between two loading protocols (immediate versus conventional) of early placed implants (Type 2-3A) in terms of clinical, radiographic, and patient-reported outcomes.\n\nNull hypothesis: There will be no significant differences in implant survival\u002Fsuccess, stability, radiographic marginal bone level, and patient reported outcomes between immediately or conventionally loaded and early placed implants.",[201],[307,308,309,310,311],"dental implant","thread design","immediate loading","conventional loading","early placement","2024-11-14",{"date":314,"type":39},"2024-11-18",{"date":316,"type":39},"2024-09-25",{"date":318,"type":20},"2026-09",{"name":45,"class":46},{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":326,"eligibilityCriteria":327,"healthyVolunteers":11,"sex":16,"minAge":328,"maxAge":329,"enrollmentInfo":330,"targetDuration":4,"studyType":21,"phases":331,"briefSummary":332,"conditions":333,"keywords":335,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":340,"lastUpdatePostDateStruct":341,"startDateStruct":343,"completionDateStruct":345,"leadSponsor":346,"locationsCount":47},"100553207","effect-of-animated-education-on-anxiety-and-vascular-complications-100553207","NCT06483087","Effect of Animated Education on Anxiety and Vascular Complications","The Effect of Animated Education Program on Anxiety, Vascular Complications, And Flat Time Among Children Undergoing Cardiac Catheterization","VAEdA","Inclusion Criteria:\n\n* aged between 6-12 years\n* admitted for their first scheduled cardiac catheterization non-emergency CC procedure.\n\nExclusion Criteria:\n\n* children with developmental delay\n* emergency CC because\n* having major hearing or visual difficulties\n* children have deteriorated health conditions before CC and need to be admitted for intensive care before undergoing CC\n* children who have bleeding disorders","6 Years","12 Years",{"count":19,"type":20},[61],"An animated education program about cardiac catheterization will be presented 24 hours to children in the intervention group before undergoing cardiac catheterization. While children in the control group will receive routine care. Dependent variables are (Anxiety 2 hours before undergoing cardiac catheterization, hematoma and bleeding at the catheterization site 2 hours post sheath removal, flat time post cardiac catheterization).",[334],"Cardiac Catheterization",[336,337,338,339],"Cardiac catheterization","Anxiety","bleeding","flat time","2024-06-30",{"date":342,"type":39},"2024-07-01",{"date":344,"type":39},"2024-03-01",{"date":210,"type":20},{"name":45,"class":46},""]