[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Karachi\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":161},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,76,108,139],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100631086","effects-of-post-isometric-relaxation-and-myofascial-release-on-low-back-pain-with-lower-cross-syndrome-100631086",false,"NCT07496099","Effects of Post-Isometric Relaxation and Myofascial Release on Low Back Pain With Lower Cross Syndrome","Combined Effects of Post-Isometric Relaxation and Myofascial Release in Patients With Low Back Pain and Lower Cross Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n1. Participants aged 18-45 years old\n2. having low back pain persisting for at least 4 weeks\n3. with clinical diagnosis of LCS, and hamstring tightness (AKE \\>15°)\n\nExclusion Criteria:\n\n1. Participants with the history of spinal surgery active neurological conditions\n2. systemic disease affecting connective tissue (Rheumatoid arthritis, Systemic lupus erythematosus)\n3. recent lower limb or spinal injury (within 6 months)\n4. pregnancy or inability to lie prone for treatment.","ALL","18 Years","45 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized controlled trial aims to evaluate the combined effects of post-isometric relaxation and myofascial release on pain, flexibility, and functional disability in individuals with low back pain associated with lower cross syndrome. Eligible participants aged 18 to 45 years will be randomly allocated into two parallel intervention groups. One group will receive post-isometric relaxation combined with myofascial release, while the comparison group will receive conventional stretching combined with Therapeutic modalities. Outcomes will be assessed at baseline and after completion of the intervention period. The results of this study are expected to contribute to evidence-based physiotherapy management of low back pain associated with postural imbalance.",[27,28,29],"Low Back Pain, Mechanical","Lower Cross Syndrome","Hamstring Muscle Tightness",[31,32,33],"Hamstring Tightness","Post-Isometric Relaxation with Myofascial Release","low back pain with lower cross syndrome","NOT_YET_RECRUITING","2026-03-22",{"date":37,"type":38},"2026-03-27","ACTUAL",{"date":40,"type":21},"2026-03-25",{"date":42,"type":21},"2026-10-20",{"name":44,"class":45},"University of Karachi","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":51,"acronym":4,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":57,"conditions":58,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":46},"100618532","symmetrical-scapula-pelvis-proprioceptive-neuromuscular-facilitation-and-superficial-back-line-in-chronic-neck-pain-with-hamstring-tightness-100618532","NCT07332845","Symmetrical Scapula-pelvis Proprioceptive Neuromuscular Facilitation and Superficial Back Line in Chronic Neck Pain With Hamstring Tightness","Inclusion Criteria:\n\n* Individual with both male and female gender\n* Individuals with chronic neck pain (pain for \\> 3 month) with hamstring tightness\n\nExclusion Criteria:\n\n* Any history related to spinal surgery\n* Previous administration of epidural injections\n* Neck pain due to specific pathology\n* Patients with radiculopathy or myelopathy\n* Traumatic spinal cord injury\n* Neck pain associated with progressive neurological deficit or loss of strength","40 Years",{"count":55,"type":21},156,[24],"A research study will be conducted at Physiotherapy department of the Sindh Institute of Physical Medicine and Rehabilitation, Karachi, Pakistan. Overall 156 patients with 18-40 years old individuals with neck pain will be eligible and they will be included through non-probability, purposive sampling technique. The written informed consent will be taken from all the patients. They will be divided through Simple random sampling (computer generated software) method into two groups, 78 in each group. Group A (experimental group) will receive PNF Symmetrical Scapula-Pelvis Patterns (PNF-SSPP), group B (control group) will receive sub occipital muscle inhibition technique (SMI) and static stretching (SS) of hamstring muscle. All participants will be assessed using assessment form. Outcome measures will be Pain, disability, disability, neck range of motions, hamstring tightness, head posture, and levator scapulae index. An independent assessor blinded to the treatment will assess all the patients for treatment outcome assessment at baseline, after first session and post treatment. Treatment sessions will be given thrice a week for 6 weeks.",[59,29,60],"Chronic Neck Pain","Neck Pain",[62,63,64,65,66],"neck ache","Exercise","Muscle Stretching","Muscle Inhibition","PNF","RECRUITING","2026-03-08",{"date":70,"type":38},"2026-03-10",{"date":72,"type":38},"2026-01-16",{"date":74,"type":21},"2026-11-26",{"name":44,"class":45},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":22,"phases":85,"briefSummary":86,"conditions":87,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":103,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},"100623407","effects-of-diagonal-proprioceptive-neuromuscular-facilitation-patterns-on-pain-and-functional-outcomes-in-patients-with-knee-osteoarthritis-100623407","NCT07396233","Effects of Diagonal Proprioceptive Neuromuscular Facilitation Patterns on Pain and Functional Outcomes in Patients With Knee Osteoarthritis","Inclusion Criteria:\n\n* Both male and females with an age range between 40-60 years.\n* Patients diagnosed with unilateral or bilateral Knee OA.\n* Grade-II or grade-III on kellgren and Lawrence classification.\n* Patients having pain intensity more than 3.4 cm on VAS as minimum cut off value.\n* Duration of knee OA more than 3 months (chronic).\n\nExclusion Criteria:\n\n* Patients with any neurological disorder.\n* History of lower limb arthroplasty or any other knee surgery.\n* Septic knee arthritis.\n* Inflammatory rheumatic disease such as rheumatoid arthritis and gout.\n* Cancer or any other malignancy such as bone tumor.\n* Knee deformities such as contracture, genu valgum and genu varum.\n* History of ligamentous injury and meniscal tear.","60 Years",{"count":84,"type":21},150,[24],"A randomized controlled trial will be conducted at the Department of Physiotherapy, Dr. Ziauddin Hospital and Al-Rayaz Hospital, Karachi, Pakistan. A total of 150 patients diagnosed with knee osteoarthritis, aged between 40-60 years, will be recruited through a non-probability purposive sampling technique. Written informed consent will be obtained from all eligible participants prior to enrollment. The participants will be randomly allocated by the help of computer generated randomization sheet, into two groups i.e. experimental and the control group, with 75 participants in each group. Group A (experimental group) will receive diagonal proprioceptive neuromuscular facilitation (PNF) pattern exercises, while Group B (control group) will receive conventional strength training exercises. Heat therapy will be administered to both groups. All participants will be assessed using a standardized assessment form. Outcome measures will include pain intensity, knee range of motion, functional disability, hamstring flexibility, dynamic balance, and fatigue level. A single blinded assessor will assess all participants at baseline and at post intervention. Treatment sessions will be given thrice a week on alternate days for 6 weeks.",[88,89,90],"Knee Osteoarthristis","Osteearthritis","Knee Pain Arthritis",[92,93,94,95,96,97,98,99],"Knee Osteoarthritis","Functional Disability","Knee Pain","Conventional Training","Osteoarthritis","Arthritis","Musculoskeletal Disease","Joint Disease","2026-02-07",{"date":102,"type":38},"2026-02-11",{"date":100,"type":38},{"date":105,"type":21},"2027-02-22",{"name":44,"class":45},2,{"id":109,"slug":110,"hasResults":11,"nctId":111,"briefTitle":112,"officialTitle":113,"acronym":114,"eligibilityCriteria":115,"healthyVolunteers":11,"sex":116,"minAge":117,"maxAge":118,"enrollmentInfo":119,"targetDuration":4,"studyType":22,"phases":121,"briefSummary":122,"conditions":123,"keywords":125,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":46},"100608706","walking-for-hypothyroidism-trial-wht-100608706","NCT07205042","Walking for Hypothyroidism Trial (WHT)","A Randomized Controlled Trial of a 12-Week Walking Program on Metabolic and Psychophysiological Outcomes in Women With Hypothyroidism","WHT","Inclusion Criteria:\n\n* Female, aged 35-55 years\n* Primary hypothyroidism with documented prior TSH \\>4.5 mIU\u002FL\n* Stable levothyroxine dose for at least 6 months\n* Sedentary lifestyle (\\\u003C150 minutes of moderate-vigorous activity per week)\n* BMI between 20-35 kg\u002Fm²\n* Able to walk unaided\n* Willing and able to provide written informed consent\n\nExclusion Criteria:\n\n* Pregnant or lactating, or planning pregnancy during the study period\n* Use of beta-blockers, systemic corticosteroids, or medications significantly affecting heart rate, HRV, or metabolism\n* Uncontrolled hypertension, insulin-dependent diabetes, symptomatic cardiovascular disease, or orthopedic conditions limiting walking\n* Major psychiatric hospitalization in the past 12 months\n* Participation in another interventional trial within the past 30 days","FEMALE","35 Years","55 Years",{"count":120,"type":21},120,[24],"Women with hypothyroidism often report persistent fatigue, weight gain, autonomic dysregulation, and stress despite stable levothyroxine therapy. This single-center, parallel-group RCT will test whether a structured, supervised 12-week walking program improves basal metabolic rate (BMR) and psychophysiological outcomes compared with usual activity. One hundred twenty women aged 35-55 with stable primary hypothyroidism will be randomized 1:1 to intervention or control.",[124],"Hypothyroidism",[126,127,128,129,130],"Walking","Aerobic Exercise","Basal Metabolic Rate","Heart Rate Variability","Salivary Cortisol","2025-09-30",{"date":133,"type":38},"2025-10-03",{"date":135,"type":21},"2025-11-01",{"date":137,"type":21},"2026-06-30",{"name":44,"class":45},{"id":140,"slug":141,"hasResults":11,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":4,"eligibilityCriteria":145,"healthyVolunteers":11,"sex":16,"minAge":82,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":4,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":153,"lastUpdatePostDateStruct":154,"startDateStruct":156,"completionDateStruct":158,"leadSponsor":160,"locationsCount":46},"100589893","wearable-biofeedback-devices-for-remote-physiotherapy-and-rehabilitation-100589893","NCT06960330","Wearable Biofeedback Devices for Remote Physiotherapy and Rehabilitation","Wearable Biofeedback Devices for Remote Physiotherapy and Rehabilitation for Elderly Patients Suffering From Arthritis and Fibromyalgia","Inclusion Criteria:\n\nElderly adults aged 60-80 years diagnosed with arthritis or fibromyalgia.\n\nExperiencing moderate to severe pain and mobility limitations.\n\nNo recent surgical interventions or contraindications for physiotherapy.\n\nAccess to smartphones and internet connectivity for remote monitoring.\n\nExclusion Criteria:\n\nPatients with severe cognitive impairments affecting adherence to rehabilitation.\n\nPresence of comorbidities that contraindicate physiotherapy (e.g., severe cardiac conditions).\n\nLack of access to digital devices required for remote monitoring.","80 Years",{"count":120,"type":21},[24],"This study evaluates the effectiveness of wearable biofeedback devices in improving pain, mobility, and rehabilitation outcomes in elderly patients with arthritis and fibromyalgia in Karachi, Pakistan. In a randomized controlled trial involving 120 participants, one group will use biofeedback-integrated devices with guided exercises and virtual consultations, while the control group receives standard physiotherapy. The results will inform the potential of digital health solutions to improve accessibility and outcomes in remote rehabilitation for chronic pain management.",[97,151,152],"Fibromyalgia","Chronic Pain","2025-04-28",{"date":155,"type":38},"2025-05-07",{"date":157,"type":21},"2025-05-06",{"date":159,"type":21},"2028-02-01",{"name":44,"class":45},""]