[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Lausanne Hospitals\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":181},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,41,66,89,123,148],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":40},"100586248","feasibility-study-to-compare-two-ventilatory-modes-for-mechanical-ventilation-weaning-100586248",false,"NCT06912906","Feasibility Study to Compare Two Ventilatory Modes for Mechanical Ventilation Weaning","Comparison of Two Strategies to Allow Mechanical Ventilation Separation Using Biphasic Airway Pressure Ventilation Without Any Synchronization (BIPAP) or Pressure Support Ventilation (PSV): a Randomized Feasibility Trial","BIWEAN","Inclusion Criteria:\n\n* Intubated ICU patient with acute respiratory failure;\n* PaO2-FiO2 ratio of less than 300 mmHg (40 kPa) at least one hour after intubation;\n* control or assist-control ventilation;\n* expected duration of mechanical ventilation of more than 24 hours;\n* clinician in charge considers that the patient can be switched to assisted ventilation (weaning phase start);\n* informed consent obtained by the patient himself \u002F legal representative or authorization received from independent physician\n\nExclusion Criteria:\n\n* less than 18 years old;\n* pregnant women (because of very different respiratory mechanics);\n* severe obesity (BMI \\> 40 kg\u002Fm2);\n* known obstructive pulmonary disease;\n* expected death within one week or very poor prognosis with end-of-life care decision expected\u002Ftreatment withdrawal;\n* neurological disorders heavily influencing breathing pattern, like suspected or proven hypoxic brain injury, spinal injury above C8, severe traumatic brain injury, polyneuropathies (ex. Guillain-Barré, myasthenia gravis);\n* home non-invasive ventilation prior to ICU admission, except CPAP for obstructive sleeping apnoea syndrome;\n* tracheostomised at ICU admission;\n* suspected or proven broncho-pleural fistulas;\n* extracorporeal membrane oxygenation (ECMO) treatment;\n* ICU admission for major burns;\n* enrolment in other trial with competitive outcomes or treatment strategies;\n* Known opposition to research participation if patient is not able to consent (eg patient with refused GC)","ALL","18 Years",{"count":20,"type":21},84,"ESTIMATED","INTERVENTIONAL",[24],"NA","We hypothesize that the ventilatory mode Bilevel Positive Airway Pressure without any synchronization (BIPAPasynchro) may facilitate the weaning process of patients intubated with acute hypoxiemic respiratory failure (AHRF) by obviating the problem of patient-ventilator asynchrony. In order to prove this hypothesis a large randomized controlled study should be perfromed comparing BIPAPasynchro versus pressure support ventilation (PSV), the most widely used ventilatory mode during the weaning process. In order to do so, a feasibility trial to demonstrate the ICU personnel can effectively use a non-standard ventilatory mode should be first performed. The objective of our study is, thus, to demonstrate the feasibility of using BIPAasynchro in the Lausanne Adult ICU.",[27],"Mechanical Ventilation Weaning","NOT_YET_RECRUITING","2025-04-10",{"date":31,"type":32},"2025-04-15","ACTUAL",{"date":34,"type":21},"2025-09-01",{"date":36,"type":21},"2027-04-15",{"name":38,"class":39},"University of Lausanne Hospitals","OTHER",2,{"id":42,"slug":43,"hasResults":11,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":11,"sex":49,"minAge":18,"maxAge":4,"enrollmentInfo":50,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":53,"conditions":54,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100553161","accurate-prostate-cancer-following-using-low-field-mri-low-prism-100553161","NCT06482489","Accurate Prostate Cancer Following Using Low-Field MRI (Low-PRISM)","Comparing Prostate Cancer Screening Between Standardized 3T MRI Screening Protocol and Low-Field MRI in a Prospective Study","Low-PRISM","Inclusion Criteria:\n\nWork Package1 (WP): 0.55T MRI Protocol Development\n\n* Healthy male volunteers aged 18 and above.\n* Agree to be contacted for incidental findings\n* Signed informed consent\n\nWP2: 0.55T Prostate MRI with patients with metallic implant(s)\n\n* Adult men (≥18 y.o) with 3T MRI reported as sub-diagnostic due to metallic implants\n* Signed informed Consent\n\nWP3: 0.55T Prostate MRI with patients with suspicious lesion(s)\n\n* Adult men (≥18 y.o)\n* PI-RADS 4\u002F5 lesions detected on 3T MRI, schedules for targeted biopsy\n* Signed informed consent\n\nExclusion Criteria:\n\nWP1: 0.55T MRI Protocol Development\n\n* Individuals with a history of prostate cancer\n* MR Contraindications as listed in the MR Safety Screening form\n\nWP2: 0.55T Prostate MRI with patients with metallic implant(s)\n\n* Contraindications as per MD instructions\n* Any condition making the patient unsuitable for the study\n* Refusal to be notified in case of incidental finding on the examination\n\nWP3: 0.55T Prostate MRI with patients with suspicious lesion(s)\n\n* Individuals with a history of prostate cancer.\n* Contraindications as per MD instructions\n* Any condition making the patient unsuitable for the study\n* Refusal to be notified in case of incidental finding on the examination","MALE",{"count":51,"type":21},74,"OBSERVATIONAL","This study compares the effectiveness of low-field MRI (0.55T) with high-field MRI (3T) in prostate cancer screening and image quality. It consists of three phases: optimizing the low-field MRI protocol with healthy volunteers, evaluating image quality in patients with metallic artifacts (like hip prostheses), and assessing low-field MRI in patients with suspicious prostate lesions found on high-field MRI.",[55],"Prostate Cancer","RECRUITING","2025-03-31",{"date":59,"type":32},"2025-04-03",{"date":61,"type":32},"2024-11-01",{"date":63,"type":21},"2025-07-31",{"name":38,"class":39},1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":73,"targetDuration":4,"studyType":52,"phases":4,"briefSummary":75,"conditions":76,"keywords":4,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":81,"lastUpdatePostDateStruct":82,"startDateStruct":84,"completionDateStruct":86,"leadSponsor":88,"locationsCount":65},"100561988","trends-of-patient-reported-outcome-measures-proms-in-multimorbid-medical-patients-hospitalized-for-an-acute-illness-100561988","NCT06597318","Trends of Patient-reported Outcome Measures (PROMs) in Multimorbid Medical Patients Hospitalized for an Acute Illness","TRADUCE","Inclusion Criteria:\n\n* eligible for the LUCID registry (CER-VD AO\\_2023-00029) \\[Age ≥ 18 years, hospitalized in one of the five participating university hospitals (Geneva, Lausanne, Bern, Zürich, Basel), after 01.01.2014, and admitted to general internal medicine wards\n* Multimorbid patients (2 or more chronic diseases, defined as chronic conditions defined by international classification of diseases, 10th revision, codes with an estimated expected duration of at least 6 months or based on a clinical decision.\n* Acute illness\n* Signature of study specific informed consent\n\nExclusion Criteria:\n\n* Not able to speak French, German or English\n* Foreseen length of stay of less than 4 days (estimated by study collaborators)\n* Prior inclusion in the TRADUCE study\n* Incapacity of discernment, i.e. cognitive impairment which could interfere with the ability to fill in PROMs tools",{"count":74,"type":21},1000,"currently, PROMs and PREMs are not routinely collected and compared among medical inpatients of Swiss university hospitals, nor is a standard set of PROMs and PREMs available for use in Swiss hospitals. The project aims to examine trends in patient-reported outcomes (PROMs), including symptoms, quality of life, and distress, in multimorbid hospitalized patients from admission to 30 days post-discharge. It will also investigate whether PROMs at discharge are linked to the risk of readmission or emergency visits and explore how these outcomes differ in patients who receive low-value care. Additionally, the project will assess the relationship between patient-reported experiences (PREMs) and the provision of low-value care during the hospital stay.",[77,78,79,80],"PROM","PREM","Quality of Care","Internal Medicine","2024-09-12",{"date":83,"type":32},"2024-09-19",{"date":85,"type":32},"2023-07-01",{"date":87,"type":21},"2025-10-01",{"name":38,"class":39},{"id":90,"slug":91,"hasResults":11,"nctId":92,"briefTitle":93,"officialTitle":94,"acronym":95,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":17,"minAge":98,"maxAge":99,"enrollmentInfo":100,"targetDuration":4,"studyType":22,"phases":102,"briefSummary":103,"conditions":104,"keywords":108,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":65},"100558570","caveat-an-open-trial-feasibility-study-100558570","NCT06552832","CAVEAT: An Open-Trial Feasibility Study","Clinician-Assisted Video Feedback Exposure-Approach Therapy (CAVEAT): An Open-Trial of a Brief Psychotherapy for Traumatized Mothers and Their Young Children","CAVEAT-OT","Inclusion Criteria:\n\n* French-speaking, biological child living with mother\n\nExclusion Criteria:\n\n* Physical and\u002For mental handicap that can interfere with participation in play and measures, active psychotic illness or substance abuse",true,"12 Months","50 Years",{"count":101,"type":21},20,[24],"This is an open-clinical trial to study the feasibility of a brief manualized psychotherapy for mothers interpersonal violence-related posttraumatic stress disorder (PTSD) and their very young children ages 1-3 years, entitled: Clinician-Assisted Videofeedback Exposure Approach Therapy (CAVEAT). This project, to be conducted with referred mothers and children to an academic medical center ambulatory care setting, intends to pilot along with the manualized intervention, pre- and post-intervention measures for up to 10 dyads over 2 years.",[105,106,107],"Parent-Child Relations","PTSD","Dissociation",[109,110,111,112,113,114],"Brief Psychotherapy","Videofeedback","Mentalization","Infant Mental Health","Parenting","Interpersonal Violence","2024-08-09",{"date":117,"type":32},"2024-08-14",{"date":119,"type":32},"2024-07-01",{"date":121,"type":21},"2026-07-31",{"name":38,"class":39},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":129,"eligibilityCriteria":130,"healthyVolunteers":97,"sex":131,"minAge":18,"maxAge":99,"enrollmentInfo":132,"targetDuration":4,"studyType":22,"phases":134,"briefSummary":135,"conditions":136,"keywords":138,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":142,"startDateStruct":144,"completionDateStruct":145,"leadSponsor":147,"locationsCount":65},"100510506","clinician-assisted-videofeedback-exposure-approach-therapy-caveat-trial-100510506","NCT05927324","Clinician-Assisted Videofeedback Exposure-Approach Therapy (CAVEAT) Trial","Can Clinician Assisted Videofeedback Exposure Approach Therapy (CAVEAT) Help Post-traumatically Stressed Mothers Change Their Mind About Their Toddlers?","CAVEAT","Inclusion Criteria:\n\n* Biological mothers of infants and young children ages 12-54 months\n* Mothers and infants have lived together most of the child's life from the time of birth\n\nExclusion Criteria:\n\n* Actively psychotic or substance-abusing mothers;\n* Mothers and\u002For children who are physically or mentally handicapped so as to prevent adequate participation in required research tasks","FEMALE",{"count":133,"type":21},24,[24],"The first study proposed is a small (n= 10 to 12 maximum) open feasibility trial of CAVEAT which is a 16-session manualized brief psychotherapy prototcol that is designed to help mothers of infants and young children, whereby the mothers have been exposed to interpersonal violence (i.e. childhood maltreatment and family violence, intimate and non-intimate partner violence, interpersonal combat and or other forms of terrorism or political violence including physical and sexual assault) and who have developed related post-traumatic stress. The treatment uses an integration and extension of evidence-based techniques: Modified Interaction Guidance, Prolonged Exposure Therapy for PTSD, Child-Parent Psychotherapy, and Minding the Baby, in order to help mothers with post-traumatic dysregulation and difficulty in their maintaining sensitivity during challenging parent-child interactions (i.e. when mothers are confronted with child helpless states, emotion dysregulation, negative affect and child aggression). Outcome measures will initially include: maternal attributions towards her child (i.e. perception of child's personality), maternal-child behavior, and maternal-child symptoms of attachment disturbance and PTSD. This feasibility study is meant to perfect the manual and to prepare for an initial open trial with a larger clinical sample including analysis of pre- and post-intervention measures before further randomized control study can be done.",[137],"Post-traumatic Stress Disorder",[114,106,139,140,141],"Women","Infants and Children","Attachment",{"date":143,"type":32},"2024-08-13",{"date":119,"type":32},{"date":146,"type":21},"2025-12-31",{"name":38,"class":39},{"id":149,"slug":150,"hasResults":11,"nctId":151,"briefTitle":152,"officialTitle":153,"acronym":4,"eligibilityCriteria":154,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":155,"enrollmentInfo":156,"targetDuration":4,"studyType":22,"phases":157,"briefSummary":160,"conditions":161,"keywords":165,"overallStatus":56,"whyStopped":4,"lastUpdateSubmitDate":173,"lastUpdatePostDateStruct":174,"startDateStruct":176,"completionDateStruct":178,"leadSponsor":180,"locationsCount":65},"100179308","phase-1-multimodal-imaging-assessment-of-the-inflammatory-atheromatous-plaque-100179308","NCT01608516","Multimodal Imaging Assessment of the Inflammatory Atheromatous Plaque","Multimodal Assessment of the Inflammatory Atheromatous Plaque : Comparison Between 68Ga-NODAGA-RGD PET\u002FCT, 18F-FDG PET\u002FCT, MRI AND US","Inclusion Criteria:\n\n* age \\\u003C= 85 years\n* Karnofsky \\>= 80%\n* patient with indication ofr carotid endarterectomy\n* signed consent form\n\nExclusion Criteria:\n\n* indication for surgery other than endarterectomy \\\u003C14 days\n* contraindication to surgery\n* contraindication to MRI\n* contraindication to gadolinium injection (stage 4\u002F5 kidney insufficiency, GFR\\\u003C30ml\u002Fmin\u002F1.73m2)\n* pregnancy, breastfeeding\n* lack of discernment","85 Years",{"count":101,"type":21},[158,159],"PHASE1","PHASE2","The present study aims at assessing the ability of 68Ga-NODAGA-RGD PET\u002FCT for the detection of inflammatory atheromatous plaques in the carotid arteries, compared to 18F-FDG PET\u002FCT, MRI and US and to determine the contribution of each imaging technique. Current gold standard for inflammation is histopathology.\n\nHypothesis : 68Ga-NODAGA-RGD might give a better initial evaluation of patients with atheromatous plaques in the carotid artery eligible for endarterectomy.",[162,163,164],"Inflammation","Atheromatous Plaques","Carotid Artery Diseases",[166,167,168,169,170,171,172],"PET\u002FCT","68Ga-NODAGA-RGD","18F-FDG","MRI","US ultrasound","inflammatory atheromatous plaque","endarterectomy","2024-06-17",{"date":175,"type":32},"2024-06-20",{"date":177,"type":32},"2012-04",{"date":179,"type":21},"2024-12",{"name":38,"class":39},""]