[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Liege\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":647},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,28,0,25,[9,40,74,101,125,153,186,206,229,266,294,322,344,371,399,423,451,474,492,516,545,566,583,604,627],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":29,"lastUpdatePostDateStruct":30,"startDateStruct":33,"completionDateStruct":35,"leadSponsor":37,"locationsCount":4},"100618450","effect-of-tdcs-timing-on-motor-recovery-in-acute-stroke-rehabilitation-100618450",false,"NCT07331779","Effect of tDCS Timing on Motor Recovery in Acute Stroke Rehabilitation","Timing Matters: Comparing Pre , Peri , and Post Rehabilitation tDCS in Acute Stroke Recovery","Inclusion Criteria:\n\n* Hospitalization for stroke rehabilitation Hospitalized in a stroke rehabilitation unit at CHU de Liège.\n\nConfirmed acute stroke Diagnosis of acute stroke (ischemic or hemorrhagic) confirmed by neuroimaging, according to local clinical practice.\n\nTime since stroke In the acute\u002Fsubacute phase, as defined in the protocol (e.g., within X days\u002Fweeks after stroke onset) - to be specified exactly as in your protocol.\n\nAge Age ≥ 18 years.\n\nCapacity to consent Able to understand the study information and provide written informed consent.\n\nMotor impairment of the upper limb Presence of motor deficit of the upper limb on the affected side, sufficient to perform the WMFT tasks (according to protocol thresholds, if specified).\n\nMedically stable Clinically stable and judged by the treating physician as able to participate in daily rehabilitation and tDCS sessions.\n\nExclusion Criteria:\n\n* Contraindications to tDCS or cranial stimulation\n\nImplanted electronic devices in the head or neck (e.g., deep brain stimulator, cochlear implant, implanted neurostimulator, pacemaker with leads near the head).\n\nMetal implants in the skull (excluding dental fillings) in the area of stimulation.\n\nLarge skull defect or craniectomy over the stimulation site.\n\nHistory of seizures History of epilepsy or unprovoked seizures not adequately controlled, if considered a contraindication to tDCS by the investigator.\n\nSevere cognitive or communication impairment Severe cognitive impairment, aphasia, or comprehension difficulties preventing understanding of the study or execution of the tasks, as judged by the investigator.\n\nSevere comorbidities Unstable medical conditions (e.g., uncontrolled cardiac, respiratory, metabolic, or systemic disease) that could interfere with participation or increase risk.\n\nSevere psychiatric disorder Current severe psychiatric illness (e.g., psychosis, severe untreated major depression) that may affect cooperation or safety, as judged by the investigator.\n\nSkin conditions at electrode sites Skin lesions, infections, severe dermatitis, or wounds at or near the planned electrode placement sites.\n\nConcurrent participation in another interventional trial Participation in another interventional clinical trial that could interfere with the outcomes or safety of this study.\n\nPregnancy Pregnancy or breastfeeding, if considered a contraindication according to local tDCS safety policy (optional, depending on your protocol stance).\n\nAny other reason Any condition or circumstance that, in the opinion of the investigator, makes the patient unsuitable for the study or unable to comply with the protocol.","ALL","18 Years",{"count":20,"type":21},60,"ESTIMATED","INTERVENTIONAL",[24],"NA","This randomized, double-blind, sham-controlled clinical trial investigates how the timing of transcranial direct current stimulation (tDCS) influences functional recovery during acute stroke rehabilitation. 198 hospitalized patients with confirmed acute stroke will be randomly assigned to one of three groups. Each day, all participants will receive three tDCS sessions: one before, one during, and one after their rehabilitation session. In each group, only one of these three daily stimulations is active, while the other two are sham, allowing a direct comparison of timing effects while maintaining blinding. All participants will complete 2 sets of five consecutive days of conventional rehabilitation combined with the tDCS protocol (2 weeks). Functional, sensory, psychological, and motor outcomes will be assessed at baseline and at the end of the intervention week. The study aims to determine whether the timing of tDCS application influences early post-stroke recovery and to inform the design of future confirmatory trials.",[27],"Acute Stroke","NOT_YET_RECRUITING","2026-06-30",{"date":31,"type":32},"2026-07-02","ACTUAL",{"date":34,"type":21},"2026-09-01",{"date":36,"type":21},"2029-12-31",{"name":38,"class":39},"University of Liege","OTHER",{"id":41,"slug":42,"hasResults":12,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":46,"eligibilityCriteria":47,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":48,"enrollmentInfo":49,"targetDuration":4,"studyType":22,"phases":51,"briefSummary":52,"conditions":53,"keywords":56,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":70,"leadSponsor":72,"locationsCount":73},"100638420","ankle-vs-hip-vs-combined-strengthening-in-chronic-ankle-instability-100638420","NCT07606534","Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle Instability","Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle Instability: A Randomized Controlled Trial","SHAC","Inclusion Criteria:\n\n* Have a history of at least one major ankle sprain that occurred at least 12 months prior to enrolment in the study, was associated with inflammatory symptoms (pain, swelling, etc), created at least one interrupted day of desired physical activity.\n* Have had at least two episodes of feeling like an \"unstable\" ankle in the six months preceding the study.\n* The Cumberland Ankle Instability Tool (CAIT) with a score of less than 24.\n* The Foot and Ankle Ability Measure (FAAM) Sport scale with a score below 80%.\n* Between 18 and 35 years old\n* Must be able to understand the study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Have had a recent injury of less than three months prior to enrolment in the study.\n* A history of surgery on the musculoskeletal structures of the lower limbs.\n* Have a history of fracture of one of the lower limbs requiring realignment.\n* Being diagnosed with a neuromuscular disease.\n* The appearance of swelling or pain in the lower limb during the experiment.","35 Years",{"count":50,"type":21},45,[24],"Chronic ankle instability (CAI) is a common condition that can develop after a lateral ankle sprain. Up to 40% of people who sprain their ankle experience a recurrence within a year, and as many as 30% develop persistent symptoms such as ankle \"giving way,\" weakness, or instability. These symptoms can limit daily activities, sports participation, and increase the risk of future sprains. Muscle weakness in both the ankle and hip has been identified as an important factor contributing to CAI. Strengthening these muscles may therefore help improve stability and function.\n\nThe SHAC study is a randomized controlled trial designed to compare three different strengthening programs in people with chronic ankle instability: (1) an ankle-focused strengthening program, (2) a hip-focused strengthening program, and (3) a combined ankle-hip strengthening program. The goal is to determine which approach leads to the greatest improvement in functional ability, muscle strength, balance, and ankle mobility.\n\nA total of 45 participants aged 18 to 35 years with documented chronic ankle instability will be recruited from local sports clubs and the University of Liège. All participants must have a history of at least one ankle sprain that occurred more than 12 months before entering the study, report episodes of ankle instability in the previous six months, and meet specific questionnaire criteria (CAIT \\\u003C 24 and FAAM Sport \\\u003C 80%). People with recent injuries, previous lower-limb surgery, fractures requiring realignment, neuromuscular conditions, or current pain or swelling will not be able to participate.\n\nAfter the first assessment (T1), participants will be randomly assigned to one of the three groups. Each intervention lasts four weeks and includes three supervised sessions per week. All strengthening exercises are isometric, performed using a handheld dynamometer to measure force accurately. The ankle program includes plantarflexion, dorsiflexion, inversion, and eversion exercises. The hip program includes clamshells, hip external rotation, abduction, and extension. The combined group alternates between hip and ankle exercises. A warm-up and standardized familiarization are performed before each session.\n\nAll participants will attend two additional assessment sessions: one immediately after the four-week program (T2) and one at a later follow-up time point (T3). During each visit, they will complete functional questionnaires, report their sports participation, and undergo several strength and performance tests. These include hip and ankle muscle strength measurements using a dynamometer, the Heel Rise Test, the modified Y-Balance Test, the Side Hop Test, and a dorsiflexion mobility test.\n\nThe study aims to identify whether one of the strengthening approaches leads to better functional outcomes for individuals with chronic ankle instability. Understanding these effects may help clinicians design more effective rehabilitation programs for people recovering from ankle sprains and for those experiencing ongoing instability.\n\nParticipant data will be kept confidential and stored securely in anonymized form for 20 years. Participation is voluntary, and individuals may withdraw at any time without consequences. Results will be presented anonymously in scientific publications and conferences.",[54,55],"Chronic Ankle Instability, CAI","Ankle Sprain",[57,58,59,60,61,62,63],"chronic ankle instability","Ankle strengthening","Hip strengthening","Isometric exercise","Physiotherapy","Rehabilitation","Randomized controlled trial","RECRUITING","2026-05-18",{"date":67,"type":32},"2026-05-26",{"date":69,"type":32},"2026-03-02",{"date":71,"type":21},"2027-09",{"name":38,"class":39},1,{"id":75,"slug":76,"hasResults":12,"nctId":77,"briefTitle":78,"officialTitle":79,"acronym":80,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":83,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":86,"conditions":87,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":4},"100639984","plasma-kinetics-of-levobupivacaine-after-transversus-abdominis-plane-tap-block-in-abdominal-surgery-100639984","NCT07581275","Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery","Plasma Kinetics of Levobupivacaine After Transversus Abdominis Plane (TAP) Block in Abdominal Surgery: A Prospective Study and Definition of a Safety Window for Intravenous Lidocaine Administration","LEVO-TAP-PK","Inclusion Criteria:\n\n* Age ≥18 years\n* Scheduled elective abdominal surgery under general anesthesia\n* Planned ultrasound-guided TAP block as part of standard perioperative analgesic care\n* Able to understand and speak French sufficiently to understand the study information and consent form\n* Able and willing to provide written informed consent\n\nExclusion Criteria:\n\n* Refusal or inability to provide informed consent\n* Known allergy or hypersensitivity to amide local anesthetics\n* Severe hepatic impairment\n* Renal impairment (estimated glomerular filtration rate \\\u003C50 mL\u002Fmin\u002F1.73 m²)\n* Contraindication to repeated blood sampling or inability to complete the sampling schedule\n* Participation in another clinical study that could affect absorption, distribution, metabolism, or elimination of local anesthetics\n* Pregnancy\n* Emergency surgery or life-threatening urgent condition\n* Immediate postoperative instability requiring intensive care transfer (e.g., hemodynamic instability)\n* Inability to understand French sufficiently for study information and consent\n* Persons requiring special legal protection for consent (e.g., minors, guardianship, incapacity to consent)","75 Years",{"count":84,"type":21},26,"OBSERVATIONAL","This prospective single-center observational pharmacokinetic study will evaluate plasma levobupivacaine concentrations after ultrasound-guided transversus abdominis plane (TAP) block in adult patients undergoing elective abdominal surgery under general anesthesia at CHU Liège. Participants receiving TAP block as part of standard clinical care (levobupivacaine 0.375%, total volume 40 mL, maximum dose 150 mg) will undergo serial blood sampling at 3, 7, 15, 30, 60, 120, and 180 minutes after block completion. Plasma levobupivacaine concentrations will be measured using validated LC-MS\u002FMS methods. The primary objectives are to estimate maximum plasma concentration (Cmax) and time to maximum concentration (Tmax). Secondary objectives include characterization of the concentration-time profile, AUC0-180, interindividual variability, and exploratory associations with clinical factors (age, sex, BMI, type of surgery). The study also aims to inform a pragmatic safety window for subsequent intravenous lidocaine infusion used in multimodal analgesia protocols. Approximately 26 participants will be enrolled. No modification of routine anesthesia or analgesic care is required apart from study-related blood sampling.",[88,89,90,91,92],"Abdominal Surgery Patients","Transversus Abdominis Plane (TAP) Block","Pharmacokinetic Analysis","Levobupivacaine","Local Anaesthetic Systemic Toxicity","2026-05-06",{"date":95,"type":32},"2026-05-12",{"date":97,"type":21},"2026-07-01",{"date":99,"type":21},"2026-12-15",{"name":38,"class":39},{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":108,"targetDuration":4,"studyType":22,"phases":110,"briefSummary":111,"conditions":112,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":120,"completionDateStruct":122,"leadSponsor":124,"locationsCount":73},"100590197","iliopsoas-ipb-and-pericapsular-nerve-group-peng-blocks-comparison-on-analgesia-and-recovery-after-total-hip-arthroplasty-100590197","NCT06964282","Iliopsoas (IPB) and Pericapsular Nerve Group (PENG) Blocks Comparison on Analgesia and Recovery After Total Hip Arthroplasty","Comparison Between Iliopsoas Block (IPB) and Pericapsular Nerve Group (PENG) Block on Postoperative Analgesia and Functional Recovery After Total Hip Arthroplasty Surgery: a Double-blinded Randomized Clinical Trial","Inclusion Criteria:\n\nAdult patients (age \\>18 years) ASA physical status classification I-III Scheduled for elective posterior approach total hip arthroplasty (THA) under spinal anesthesia\n\nExclusion Criteria:\n\nPregnancy (confirmed by beta-HCG test if applicable) Known peripheral neuropathy or major neurological disease Chronic pain syndromes or long-term opioid use (\\>20 mg oral morphine equivalents\u002Fday) Severe hepatic or renal insufficiency Allergy to local anesthetics Major coagulopathies Vulnerable patients (e.g., minors, legally protected individuals)",{"count":109,"type":21},118,[24],"Background:\n\nIn recent years, regional anesthesia has become more popular because it can reduce pain and the need for strong pain medications like morphine. For hip surgery, the PENG block is already known to be effective. A newer method, called the iliopsoas plane block (IPB), is very similar and has also shown good results in hip arthroscopy. However, these two techniques have never been directly compared in patients undergoing hip replacement surgery using the posterior approach.\n\nGoal:\n\nThis study aims to see if the IPB is just as effective as the PENG block for controlling pain and helping patients recover well after hip replacement surgery.\n\nMethod:\n\n118 adult patients scheduled for hip replacement under spinal anesthesia will be randomly assigned to receive either: IPB: 7 ml of Ropivacaine 7.5 mg\u002Fml PENG: 14 ml of Ropivacaine 3.75 mg\u002Fml Both injections are given under ultrasound guidance 30 minutes before spinal anesthesia. Neither the patient, the surgeon, nor the data collector will know which technique was used.\n\nPost-Surgery Care:\n\nAll patients will receive standard pain relief, including:\n\nParacetamol every 6 hours Etoricoxib once a day Morphine via a patient-controlled pump for 48 hours\n\nMain Outcome Measured:\n\nThe primary goal is to compare pain during movement 6 hours after surgery, using a pain scale from 0 (no pain) to 10 (worst pain). The study will consider the two blocks equivalent if the difference in average pain scores is less than 1 point.\n\nOther Outcomes:\n\nTotal morphine used in 48 hours Pain scores at rest and during movement at various time points Walking ability (2- and 6-minute walk tests, and timed-up-and-go test) Quality of recovery (using the QoR-15 questionnaire) Side effects of morphine Patient satisfaction Length of hospital stay\n\nSafety:\n\nBoth techniques are safe and already used in clinical practice. Ultrasound guidance minimizes risks like nerve injury, bleeding, or infection.\n\nConclusion:\n\nIf the IPB is shown to be as effective as the PENG block, both can be considered reliable options for pain control and early recovery after hip replacement surgery.",[113,114,115,116,117],"Total Hip Arthroplasty (THA)","Postoperative Pain Management","Peripheral Nerve Blocks","PENG Block","Iliopsoas Nerve Block","2026-04-29",{"date":93,"type":32},{"date":121,"type":32},"2025-10-01",{"date":123,"type":21},"2026-10-10",{"name":38,"class":39},{"id":126,"slug":127,"hasResults":12,"nctId":128,"briefTitle":129,"officialTitle":130,"acronym":4,"eligibilityCriteria":131,"healthyVolunteers":132,"sex":17,"minAge":18,"maxAge":133,"enrollmentInfo":134,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":135,"conditions":136,"keywords":139,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":73},"100629263","mobility-strength-and-functional-outcomes-before-surgery-at-3-months-and-at-6-months-after-hip-arthroscopy-for-femoroacetabular-impingement-syndrome-100629263","NCT07472400","Mobility, Strength, and Functional Outcomes Before Surgery, at 3 Months, and at 6 Months After Hip Arthroscopy for Femoroacetabular Impingement Syndrome","Mobility, Strength, and Functional Outcomes Before Surgery, at 3 Months, and at 6 Months","Inclusion Criteria:\n\n* Subjects with femoroacetabular impingement syndrome, with corresponding clinical symptoms and signs, as well as validation by imaging\n* Subjects who have already consulted a surgeon specializing in hip arthroscopic surgery and whose surgery is planned to treat femoroacetabular impingement syndrome\n* Subjects aged between 18 and 40\n\nExclusion Criteria:\n\n* History of rheumatic disease, dysplasia or pediatric disease affecting the hip (Legg-Calvé; superior femoral epiphysiolysis)\n* Subject who has already undergone surgery on the hip joint\n* Subjects with a history of injury to the muscles involved in the assessments within the last year",true,"40 Years",{"count":20,"type":21},"The aim of this study is to identify the factors associated with successful rehabilitation following hip arthroscopy for femoroacetabular impingement syndrome and to highlight any persistent functional deficits at different key stages of rehabilitation. This is a controlled multi-observational study. The pathological hip of patients will be compared to their second healthy hip as well as to a healthy control group.\n\nAssessments of mobility, strength, functional tests, and questionnaire submissions will take place before the intervention and 3 and 6 months after the intervention.",[137,138],"Femoroacetabular Impingement Syndrome","Healthy Participants",[140,141,142,143,144],"Femoroacetabular impingement syndrome","Physical impairments","Questionnaires","Strength","mobility","2026-04-28",{"date":147,"type":32},"2026-05-05",{"date":149,"type":32},"2026-03-01",{"date":151,"type":21},"2027-06-30",{"name":38,"class":39},{"id":154,"slug":155,"hasResults":12,"nctId":156,"briefTitle":157,"officialTitle":158,"acronym":159,"eligibilityCriteria":160,"healthyVolunteers":132,"sex":161,"minAge":162,"maxAge":163,"enrollmentInfo":164,"targetDuration":4,"studyType":22,"phases":166,"briefSummary":167,"conditions":168,"keywords":170,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":180,"startDateStruct":182,"completionDateStruct":184,"leadSponsor":185,"locationsCount":73},"100633168","effects-of-a-targeted-prevention-program-on-change-of-direction-biomechanics-and-performance-in-elite-female-soccer-players-100633168","NCT07523178","Effects of a Targeted Prevention Program on Change-of-Direction Biomechanics and Performance in Elite Female Soccer Players","Impact of a Targeted Prevention Program on Biomechanics and Performance During Change-of-Direction Tasks in Elite Female Soccer Players: An Interventional Study","PREV-COD-FF","Inclusion Criteria:\n\n* Female soccer players aged 13 to 16 years\n* Female soccer players training at least 3 times per week\n* Ability to provide informed consent (parental consent required for minors)\n\nExclusion Criteria:\n\n* Previous lower-limb surgery\n* Current musculoskeletal injury\n* Refusal to participate or withdrawal of consent","FEMALE","13 Years","16 Years",{"count":165,"type":21},51,[24],"Anterior cruciate ligament (ACL) injuries are common in female soccer and frequently occur during change-of-direction (COD) movements without contact. Biomechanical deficits during these movements are considered important risk factors.\n\nThis study aims to evaluate the effects of a targeted injury-prevention program on biomechanical movement quality and performance during change-of-direction tasks in female soccer players.\n\nParticipants will perform a 90° cutting task during which biomechanical movement quality will be assessed using the Cutting Movement Assessment Score (CMAS), while performance will be evaluated using cutting time measured with photoelectric timing gates. Participants will also perform the 505 Agility Test to assess additional change-of-direction performance.\n\nIn addition, subjective perceptions of functional confidence and performance will be collected using Likert-scale questionnaires.\n\nThe study will assess whether a structured prevention program integrated into regular training can improve biomechanical movement patterns and change-of-direction performance.",[169],"Anterior Cruciate Ligament Injury",[171,172,173,174,175,176,177,178],"Injury Prevention","ACL Injury Prevention","Female soccer","Change of Direction","Cutting Task","CMAS","505 Agility Test","Neuromuscular Training","2026-04-13",{"date":181,"type":32},"2026-04-17",{"date":183,"type":21},"2026-03-30",{"date":65,"type":21},{"name":38,"class":39},{"id":187,"slug":188,"hasResults":12,"nctId":189,"briefTitle":190,"officialTitle":190,"acronym":4,"eligibilityCriteria":191,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":192,"enrollmentInfo":193,"targetDuration":4,"studyType":22,"phases":195,"briefSummary":196,"conditions":197,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":179,"lastUpdatePostDateStruct":199,"startDateStruct":201,"completionDateStruct":203,"leadSponsor":205,"locationsCount":73},"100392893","samba-trial-towards-a-paradigm-shift-in-severe-asthma-management-deep-analysis-of-the-effect-of-submaximal-aerobic-training-100392893","NCT04395937","SAMBA Trial: Towards a Paradigm Shift in Severe Asthma Management: Deep Analysis of the Effect of suBmaximal Aerobic Training","Inclusion Criteria:\n\n* asthmatic patient\n* aged 18- 65 years\n* ACQ \\> 1.5\n* stable background treatment comprising at least one inhaled corticosteroid or an anti-leukotriene\n\nExclusion Criteria:\n\n* IMC \\> 35\n* severe osteoarthritis of the knees and hips\n* unstable angor\n* Severe uncontrolled hypertension","65 Years",{"count":194,"type":21},100,[24],"The effects of regular exercise on asthma control has not yet been well demonstrated.\n\nThe aim of this study is to investigate the impact of submaximal aerobic training on exercise tolerance (VO2max - primary outcome) and a set of secondary outcomes: quality of life, asthma symptoms control, bronchial and systemic inflammatory markers, lung function, bronchial hyperresponsiveness, anxiety and depression and body composition in patients with persistant asthma.",[198],"Chronic Asthma",{"date":200,"type":32},"2026-04-14",{"date":202,"type":32},"2020-09-01",{"date":204,"type":21},"2028-09-01",{"name":38,"class":39},{"id":207,"slug":208,"hasResults":12,"nctId":209,"briefTitle":210,"officialTitle":211,"acronym":212,"eligibilityCriteria":213,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":214,"targetDuration":4,"studyType":22,"phases":216,"briefSummary":217,"conditions":218,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":73},"100632446","the-impact-of-a-3d-imaging-tool-on-reducing-gum-recession-during-orthodontic-treatment-with-aligners-100632446","NCT07513792","The Impact of a 3D Imaging Tool on Reducing Gum Recession During Orthodontic Treatment With Aligners","The Impact of a 3D Imaging Visualization Tool for Orthodontic Treatment With Aligners in Reducing Periodontal Recession Occurrence","GOPRO","Inclusion Criteria:\n\n* more than 18years old\n* requesting an orthodontic treatment with aligners\n* dental class I or slight class II or III\n* presence of black corridors\n\nExclusion Criteria:\n\n* agenesis or extraction except for the 3rd molars\n* need of extraction for the orthodontic treatment-need for orthognathic surgery\n* generalized unilateral, bilateral, or anterior crossbite\n* active periodontal disease\n* presence of severe recession (≥2mm)\n* furcation involvement\n* absence of keratinized tissues\n* smoker \\> 10c\u002Fday-auto-immune disease or immunocompromised patients\n* uncontrolled diabetes\n* use of steroids or biphosphonates-local or systemic infection (medical treatment needed prior to entrance to the study)\n* pregnancy\n* alcoholism or chronically drug abuse",{"count":215,"type":21},40,[24],"This study investigates whether using 3D imaging technology (Cone Beam Computed Tomography or CBCT) for orthodontic treatment planning with aligners can reduce the risk of gingival recession in adult patients seeking dental arch expansion. Many aligner treatments involve expanding the dental arches to address issues like crowding and \"black corridors,\" but this can sometimes lead to gum recession.\n\nThe research compares two groups of patients: one group will have their treatment planned using CBCT, which allows for detailed 3D visualization of the teeth and bone structure, while the other group will follow a conventional 2D treatment plan. The goal is to see if the 3D tool helps prevent gum recession and other periodontal problems like bone thinning, as well as to assess the impact on other factors like upper airway dimensions.\n\nThe study is a randomized controlled trial with 40 participants. It will track changes in gum health, bone structure, and airway volume over the course of treatment. The researchers aim to find out if the advanced imaging tool provides significant benefits compared to traditional planning methods.",[219,220,221],"Orthodontic","Gingival Recession","Cone-Beam Computed Tomography",{"date":223,"type":32},"2026-04-07",{"date":225,"type":32},"2025-09-04",{"date":227,"type":21},"2027-06-01",{"name":38,"class":39},{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":132,"sex":17,"minAge":236,"maxAge":237,"enrollmentInfo":238,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":247,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":258,"lastUpdatePostDateStruct":259,"startDateStruct":261,"completionDateStruct":263,"leadSponsor":265,"locationsCount":73},"100623124","virtual-reality-as-a-tool-for-training-public-speaking-skills-in-higher-education-students-100623124","NCT07392554","Virtual Reality as a Tool for Training Public Speaking Skills in Higher Education Students","Virtual Reality as a Tool for Training Public Speaking Skills in Higher Education Students: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Higher education student\n* Speaking french fluently\n\nExclusion Criteria:\n\n* Hearing impairment\n* Voice or fluency disorder at the time of the study","20 Years","30 Years",{"count":239,"type":21},80,[24],"According to the scientific literature, public speaking (PS) is an important skill for students to master. However, a large proportion of students do not feel comfortable speaking in public. PS anxiety impacts oral communication (i.e., voice and fluency). These changes can affect speaker's academic and professional success, as well as his credibility. Performing a high-quality PPP with confidence is therefore rarely an innate skill, but fortunately it can be trained and improved. Therefore, training PS skills in representative settings is crucial but often challenging for PS professionals (e.g., speech therapists, vocologists, coaches).\n\nThis project examines how oral communication skills training including simulations in virtual reality (VR) supports the acquisition of effective oral PS skills. Using acoustic analyses, outcomes from participants in the intervention group (N = 40) will be compared with those of a wait-list control group (N = 40) to determine whether significant differences emerge in filled pauses, speech rate, and vocal intonation during PS. Changes in PS self-efficacy will also be assessed. Regarding secondary outcomes, the study will evaluate changes in self-reported and physiological PS anxiety, as well as self-reported confidence as a speaker. Finally, self-perceived vocal effort during PS will be examined.",[243,244,245,246],"Voice","Speech","Virtual Reality Simulation","Healthy Adult",[248,249,243,250,251,252,253,254,255,256,257],"Public Speaking","Oral Communication","Speech Fluency","Speech Therapy","Virtual Reality","Students","Training","Glossophobia","Anxiety","Verbal Behavior","2026-01-30",{"date":260,"type":32},"2026-02-06",{"date":262,"type":21},"2026-03",{"date":264,"type":21},"2026-12",{"name":38,"class":39},{"id":267,"slug":268,"hasResults":12,"nctId":269,"briefTitle":270,"officialTitle":271,"acronym":4,"eligibilityCriteria":272,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":82,"enrollmentInfo":273,"targetDuration":4,"studyType":22,"phases":274,"briefSummary":275,"conditions":276,"keywords":280,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":293,"locationsCount":73},"100617295","eccentric-cycling-in-multiple-sclerosis-rehabilitation-100617295","NCT07316764","Eccentric Cycling in Multiple Sclerosis Rehabilitation","Eccentric Cycling : a New Training Modality in Multiple Sclerosis Rehabilitation","Inclusion Criteria:\n\n* Diagnosis of multiple sclerosis\n* Multiple sclerosis: EDSS score \\\u003C 7\n* Age under 75 years\n* Stable disease state\n* Written medical clearance authorizing participation\n* Legal adult status\n* Written informed consent, with demonstrated understanding of the consent form (via a few specific questions)\n* Ability to mobilize independently (e.g., transfers, walking)\n\nExclusion Criteria:\n\n* One or more contraindications to physical activity\n* Significant comorbidities\n* Current hospitalization or undergoing changes in medication\n* Active flare-up",{"count":20,"type":21},[24],"The project aims to optimise functional rehabilitation programmes for people with multiple sclerosis.\n\nInvestigators are proposing eccentric cycling as a new exercise modality for treating these patients.\n\nBased on previous results in healthy subjects, investigators will attempt to define the optimal parameters of this new modality (in terms of duration, intensity, frequency, etc.).\n\nInvestigators also aim to demonstrate the effectiveness of this training (compared to conventional training) in improving muscle function, functional capacity, perception of chronic fatigue, quality of life, physical condition, and neurological and cognitive function.",[277,62,278,279],"Multiple Sclerosis","Neuro-Degenerative Disease","Neurorehabilitation",[281,282,283,284,285,286],"eccentric cycling","multiple sclerosis","eccentric training","neurorehabilitation","physical therapy","neuro-degenerative disease","2025-12-23",{"date":289,"type":32},"2026-01-05",{"date":291,"type":21},"2026-01",{"date":264,"type":21},{"name":38,"class":39},{"id":295,"slug":296,"hasResults":12,"nctId":297,"briefTitle":298,"officialTitle":299,"acronym":300,"eligibilityCriteria":301,"healthyVolunteers":132,"sex":17,"minAge":133,"maxAge":192,"enrollmentInfo":302,"targetDuration":4,"studyType":22,"phases":304,"briefSummary":305,"conditions":306,"keywords":308,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":320,"locationsCount":321},"100611231","impact-of-a-physical-activity-intervention-on-cardiometabolic-health-mental-health-and-lifestyle-factors-100611231","NCT07237893","Impact of a Physical Activity Intervention on Cardiometabolic Health, Mental Health, and Lifestyle Factors.","Cardiometabolic Health, Mental Health, and Lifestyle Factors in the Meuse-Rhine Region and the Impact of a Physical Activity Intervention: the Interreg Meuse-Rhine Blue Zone Project.","IMR-BZ","Inclusion Criteria:\n\n* Aged between 40 and 65 years\n* Resident of Belgian Limburg, Liège, Netherlands Limburg or Aachen, with the intention to remain there for at least one year\n* Able to wear a wrist-worn wearable for at least 10 hours per day during waking hours\n* Own a smartphone and have a valid email address\n* Adequate proficiency in Dutch or English, defined as the ability to read, understand, and ask questions\n\nExclusion Criteria:\n\n\\- Pregnant and plans to become pregnant within the next year.",{"count":303,"type":21},1000,[24],"The first objective of this study is to compare cardiometabolic and mental health across the four interregion Meuse-rhine (IMR). The second objective is to compare six key lifestyle pillars, as defined by the American College of Lifestyle Medicine: physical activity, diet, stress management, sleep quality, social connection, and substance use. Physical activity will be objectively and continuously monitored using a wearable device, while the other five lifestyle factors will be assessed through validated questionnaires at pre- and postintervention. Finally, we will evaluate the effects of a physical activity intervention on cardiometabolic health, mental health, and the six lifestyle pillars. By addressing these objectives, this study aims to generate valuable insights to inform policymakers and support region-specific interventions for improving health and lifestyle across the IMR.\n\nThis multicentric interventional study will be conducted at four sites: Hasselt University, Liège University, Maastricht University, and Aachen University. The study includes a pre- and post-intervention visit, with a three-month intervention period followed by a three-month follow-up. Participants will be recruited via a subscription link, where they will provide demographic information after giving informed consent. Based on the inclusion criteria, 1000 participants will be included in total (250 participants per site). Ethical approval documents for the two sites in Belgium will be submitted simultaneously. Documents for Maastricht University and Aachen University will be submitted afterward, and the ethical approvals will be sent to the Belgian ethical committees.\n\nA quota for educational level will be implemented, limiting highly educated participants to a maximum of 25% per region to reflect the educational distribution of the IMR population. This ensures a more representative sample, as highly educated individuals are often overrepresented in research.\n\nTo minimise seasonal effects on physical activity, participant inclusion will be divided into four groups and spread throughout the year. At each site, approximately 65 participants will start in September 2025, another group in December '25\u002FJanuary '26, a third group in March\u002FApril '26, and a final group in June\u002FJuly '26.\n\nParticipants will be recruited through online and paper advertisements, including a subscription link to the screening questionnaire. Selected participants will receive detailed study information via phone or email, based on their indicated preference. Data from unselected participants will be deleted after recruitment is completed. Those who agree to participate will be invited for a first study visit, where they will provide written informed consent. Selected participants may withdraw at any time for any reason. In such cases, previously collected research data will be retained, but contact details will be deleted, and their name will be removed from the subject identification list.\n\nDuring the first study visit, all study procedures and outcome measures will be explained, and participants will provide written informed consent. Next, they will complete questionnaires on their sociodemographic factors, mental health and lifestyle factors using an iPad or computer. These questionnaires will be accessed via a secured link sent by the EDC Castor system to a fictitious email address created in advance for each participant. A member of the research team will prepare the questionnaires for each participant and verify their correct submission afterward. Following this, blood pressure and anthropometric measurements will be taken, and a venous blood sample will be drawn by a certified nurse or doctor. Participants will then receive their wearable along with assistance for installation and connection to their smartphone. Additionally, a subsample of participants (n = 75 per site) will be asked to install M-Path on their smartphone for ecological momentary assessment of mental health. Technical support will be provided as needed.\n\nThe same measurements will be repeated during the post-intervention study visit. For sociodemographic factors, participants will be asked if any changes have occurred and, if so, to specify them. In addition, participants will have to answer four questions on intervention adherence and possible barriers they experienced. Statistical analysis will be performed using IBM SPSS Statistics (version 28.0.1.1, IBM Corp., Armonk, NY, USA).",[307],"Healthy",[309,310,311,312],"Physical activity","preventive medicine","lifestyle","health litteracy","2025-11-14",{"date":315,"type":32},"2025-11-20",{"date":317,"type":21},"2025-11-24",{"date":319,"type":21},"2027-01-01",{"name":38,"class":39},4,{"id":323,"slug":324,"hasResults":12,"nctId":325,"briefTitle":326,"officialTitle":327,"acronym":328,"eligibilityCriteria":329,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":330,"targetDuration":4,"studyType":22,"phases":332,"briefSummary":333,"conditions":334,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":336,"lastUpdatePostDateStruct":337,"startDateStruct":339,"completionDateStruct":341,"leadSponsor":343,"locationsCount":73},"100593327","paratracheal-vs-cricoid-pressure-on-glittic-deformation-paraglide-100593327","NCT07004998","PARAtracheal vs CRIcoid Pressure on GLIttic DEformation (PARAGLIDE)","Comparison of Left Paratracheal Versus Cricoid Pressure on Glottic Visualization During Videolaryngoscopy: A Randomized Crossover Study","PARAGLIDE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Scheduled for elective surgery under general anesthesia requiring endotracheal intubation\n* ASA physical status I or II\n* Normal airway anatomy as assessed by the anesthesiologist (Mallampati I-II, no known or anticipated difficult airway)\n* Written informed consent obtained prior to inclusion\n\nExclusion Criteria:\n\n* History of difficult intubation or anticipated difficult airway\n* Known upper airway anatomical abnormalities (e.g., tumors, tracheal deviation, cervical spine instability)\n* BMI \\> 35 kg\u002Fm²\n* Gastroesophageal reflux disease or increased aspiration risk\n* Pregnancy\n* Emergency surgery\n* Allergy or contraindication to any anesthetic drugs used\n* Inability to provide informed consent",{"count":331,"type":21},50,[24],"This randomized crossover study evaluates the effects of left paratracheal pressure, cricoid pressure, and no pressure on glottic visualization during videolaryngoscopy in adult surgical patients. The primary endpoint is the Percentage of Glottic Opening (POGO) score assessed by blinded video review. Secondary endpoints include anatomical measures (glottic surface area, vertical and horizontal displacement of the glottic plane) and clinical outcomes (first-pass success, first-pass success without desaturation \\\u003C90%, intubation time, Intubation Difficulty Scale, hypoxemia, hemodynamic events, airway trauma, and postoperative sore throat or dysphonia). All outcomes are collected from routine anesthetic practice and video analysis, with no additional procedures.",[335],"Airway Management","2025-09-15",{"date":338,"type":32},"2025-09-19",{"date":340,"type":21},"2025-09",{"date":342,"type":21},"2025-12",{"name":38,"class":39},{"id":345,"slug":346,"hasResults":12,"nctId":347,"briefTitle":348,"officialTitle":349,"acronym":350,"eligibilityCriteria":351,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":352,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":354,"conditions":355,"keywords":360,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":366,"completionDateStruct":368,"leadSponsor":370,"locationsCount":73},"100596705","episodes-of-disconnected-consciousness-in-icu-survivors-100596705","NCT07048951","Episodes of (Dis)Connected Consciousness in ICU Survivors","Episodes of (Dis)Connected Consciousness Among Patients Who Survived a Critical Illness","CONSCIOUS-ICU","Inclusion Criteria:\n\n* Adult patients who survived a ≥7 days stay in the intensive care unit\n* Experienced a pharmacological or non-pharmacological episode of loss of consciousness\n* French speaking\n\nExclusion Criteria:\n\n* Refusal\n* Chronic disorder of consciousness\n* Confusion or delirium\n* Deafness\n* Blindness\n* Aphasia",{"count":353,"type":21},200,"This single-center observational study aims to describe the incidence of episodes of connected consciousness and disconnected consciousness (including near-death experience (NDE) and out-of-body experiences) in patients who survived a prolonged stay of at least 7 days in the intensive care unit (ICU) and who had at least one episode of pharmacological or non-pharmacological coma. The investigators are also investigating the risk factors related to these episodes of consciousness. A follow-up at six months aims to explore the long-term psychological implications of these episodes.",[356,357,358,359],"Consciousness","Near Death Experience","ICU","Critical Illness",[361,362],"near-death experience","out-of-body experience","2025-06-24",{"date":365,"type":32},"2025-07-03",{"date":367,"type":32},"2025-04-01",{"date":369,"type":21},"2027-04",{"name":38,"class":39},{"id":372,"slug":373,"hasResults":12,"nctId":374,"briefTitle":375,"officialTitle":376,"acronym":377,"eligibilityCriteria":378,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":192,"enrollmentInfo":379,"targetDuration":4,"studyType":22,"phases":381,"briefSummary":382,"conditions":383,"keywords":385,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":391,"lastUpdatePostDateStruct":392,"startDateStruct":394,"completionDateStruct":396,"leadSponsor":398,"locationsCount":73},"100594270","transcutaneous-auricular-vagus-nerve-stimulation-for-persistent-post-concussion-symptoms-100594270","NCT07017257","Transcutaneous Auricular Vagus Nerve Stimulation for Persistent Post-concussion Symptoms","Effects of Transcutaneous Auricular Vagus Nerve Stimulation in Patients With Persistent Post-concussion Symptoms: a Randomized Double-blind Controlled Trial","taVNS-PPCS","Inclusion Criteria:\n\n* Age between 18 and 65;\n* Between 4 weeks and 1-year post-diagnosis of a concussion;\n* Score equal or above 16 on the Rivermead Post-Concussion Questionnaire;\n* Intact skin at the electrode site.\n\nExclusion Criteria:\n\n* History of chronic neurological or psychological disorders (still untreated 6 months preceding inclusion);\n* Pregnancy or breastfeeding;\n* Presence of an active implant (e.g., pacemaker, cochlear implant);\n* History of myocardial infarction or cardiac arrhythmia;\n* Excessive alcohol consumption (\\> 14 drinks per week) and\u002For drug (\\> 1x\u002Fweek) use within the past 6 months.",{"count":380,"type":21},48,[24],"Persistent post-concussive symptoms (PPCS) affect a significant proportion of individuals following a concussion, leading to debilitating impacts on their quality of life and work capacity. Currently, effective treatments for PPCS are limited, despite their lasting and debilitating impact. Transcutaneous auricular vagus nerve stimulation (taVNS), a non-invasive neuromodulation technique, holds promise as a therapeutic option by leveraging the bottom-up modulation of brain activity via the auricular branch of the vagus nerve. This study aims to evaluate the neurophysiological and clinical effects of taVNS on brain activity and symptomatology in patients with PPCS through a randomized, controlled, double-blind trial.",[384],"Persistent Post-concussive Symptoms",[386,387,388,389,390],"Vagus nerve stimulation","Transcutaneous electrical nerve stimulation","Non-invasive brain stimulation","Persistent post-concussive symptoms","High-density EEG","2025-06-03",{"date":393,"type":32},"2025-06-12",{"date":395,"type":32},"2025-05-28",{"date":397,"type":21},"2027-06",{"name":38,"class":39},{"id":400,"slug":401,"hasResults":12,"nctId":402,"briefTitle":403,"officialTitle":404,"acronym":4,"eligibilityCriteria":405,"healthyVolunteers":12,"sex":161,"minAge":18,"maxAge":4,"enrollmentInfo":406,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":408,"conditions":409,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":422},"100587395","frequency-of-occurrence-and-risk-factors-of-postoperative-nausea-and-vomiting-during-elective-c-section-under-spinal-anesthesia-with-preventive-medication-100587395","NCT06927830","Frequency of Occurrence and Risk Factors of Postoperative Nausea and Vomiting During Elective C-section Under Spinal Anesthesia With Preventive Medication","Incidence and Risk Factors of Postoperative Nausea and Vomiting (PONV) During Elective C-Section Under Spinal Anesthesia With Multimodal Antiemetic Prophylaxis","Inclusion Criteria:\n\nAny patient requiring elective caesarean section under spinal anesthesia, at a gestational age \\>37 weeks of amenorrhea in the context of a single-fetal pregnancy.\n\nExclusion Criteria:\n\nFailure to understand the French language; Contraindication to locoregional anesthesia; Nausea and\u002For vomiting in the 24 hours preceding the procedure; Type 1 or type 2 insulin-requiring non-gestational diabetes; Allergy or contraindication to one of the products used in the usual management protocol; Severe preeclampsia; Height \\\u003C150 cm",{"count":407,"type":21},400,"The aim of this study is to learn about the incidence and risk factors of nausea and vomiting during planned caesarean section under spinal anesthesia.\n\nThe main question it aims to answer is : What are the incidence and risks factors of postoperative nausea and vomiting (NV) during planned caesarean section under spinal anesthesia with administration of intrathecal morphine and multimodal antiemetic prophylaxis ?\n\nPatients who will be managed according to the standard protocol in use in the department will have to answer specific questions about NV in the post-interventional recovery room and on 2 further visits in the first 24 hours post-caesarean section.",[410,411,412,413],"Nausea and Vomiting, Postoperative","Cesarean Delivery","Spinal Anesthesia","Antiemetic Therapy","2025-04-14",{"date":416,"type":32},"2025-04-15",{"date":418,"type":32},"2025-03-19",{"date":420,"type":21},"2026-04",{"name":38,"class":39},2,{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":431,"enrollmentInfo":432,"targetDuration":4,"studyType":22,"phases":433,"briefSummary":436,"conditions":437,"keywords":439,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":321},"100455638","phase-2-apomorphine-in-severe-brain-injured-patients-100455638","NCT05213169","Apomorphine in Severe Brain-injured Patients","Randomized Controlled Trial of Apomorphine in Severe Brain-injured Patients: a Double-blind Behavioral and Neuroimaging Study","APODoC","Inclusion Criteria:\n\n* 18-80 years old.\n* Clinically stable, not dependent on medical ventilators for respiration.\n* Diagnosed as in an unresponsive wakefulness syndrome or minimally conscious state according to the international criteria and based on at least 2 consistent CRS-R in the last 14 days (one CRS-R in the last 7 days).\n* More than 4 weeks post-insult.\n* No serious neurological impairments others than related to their acquired brain injury.\n* No neurological medications other than anti-epileptic or anti-spasticity drugs within the last two weeks.\n* No use of dopaminergic medications other than apomorphine within the last two weeks.\n* Informed consent from legal representative of the patient (if patients recover, their consent will also be obtained).\n\nExclusion Criteria:\n\n* Use of dopamine agonists or antagonists (e.g. amantadine, bromocriptine, l-dopa, pramipexole, ropinirole, amphetamine, bupropion, methylphenidate \u002F risperidone, haloperidol, chlorpromazine, flupentixol, clozapine, olanzapine, quetiapine) in the last 4 weeks or 4 half-lives of the drug.\n* Use of drugs with known significant prolongation of the QT interval (e.g. class 1 antiarrythmics, sotalol, macrolides, quinolones, antipsychotic drugs, tricyclic antidepressants. Methadone, chloroquine, quinine)\n* A corrected QT interval over 480ms (calculated using Bazett's formula on a standard 12-lead ECG recorded in the last 14 days) or other risk factors for arrhythmia (congestive cardiac failure, severe hepatic impairment or significant electrolyte disturbance).\n* A history of previous neurological functional impairment.\n* Contraindication to MRI, EEG, or PET (e.g., electronic implanted devices, active epilepsy, external ventricular drain).\n* Use of nitrates or other vasodilators, central nervous system acting agents such as barbiturates, morphine and related drugs (relative exclusion criterion)","80 Years",{"count":380,"type":21},[434,435],"PHASE2","PHASE3","Background:\n\nPatients who survive severe brain injury may develop chronic disorders of consciousness (DoC). Treating these patients to improve recovery is extremely challenging because of scarce and inefficient therapeutical options. Among pharmacological treatments, apomorphine, a potent direct dopamine agonist, has exhibited promising behavioral effects, but its true efficacy and its mechanism remains unknown. This randomized controlled study aims to verify the effects of apomorphine subcutaneous infusion in patients with disorders of consciousness and investigate the neural networks targeted by this treatment.\n\nMethods\u002Fdesign:\n\nThe double-blind randomized controlled trial will include 48 patients: 24 patients will be randomly assigned to the apomorphine and 24 to the placebo group. Investigators and the patients will be unaware of the nature of the treatment rendered.\n\nPrimary outcome will be determined as behavioral response to treatment as measured by changes of diagnosis using the Coma Recovery Scale - Revised (CRS-R), while secondary outcome measures will include the Nociception Coma Scale - Revised (NCS-R), Disability Rating Scale (DRS), Wessex Head Injury Matrix (WHIM), circadian rhythm using actimetry, electroencephalography (EEG), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). The Glasgow Outcome Scale - Extended (GOS-E) and a phone-adapted version of the CRS-R will be used for long-term follow-up.\n\nStatistical analyses will focus on the detection of changes induced by apomorphine treatment at the individual level (comparing data before and after treatment) and at the group level (comparing responders with non-responders). Response to treatment will be measured at four different levels: 1. behavioral response (CRS-R, NCS-R, DRS, WHIM, GOS-E, phone CRS-R), 2. brain metabolism (PET), 3. network connectivity (resting-state fMRI, clinical EEG and high-density EEG) and 4. Circadian rhythm changes (actimetry, body temperature, 24h-EEG).\n\nDiscussion:\n\nApomorphine is a promising and safe strategy for the treatment of DoC but efficacy, profile of the responding population and underlying mechanism remain to be determined. This trial will provide unprecedented data that will allow to investigate the response to apomorphine using multimodal methods and shed new light on the brain networks targeted by this drug in terms of behavioral response, functional connectivity and metabolism.",[438],"Disorder of Consciousness",[440,441,442,443],"unresponsive wakefulness syndrome","minimally conscious state","apomorphine","treatment","2025-04-10",{"date":416,"type":32},{"date":447,"type":32},"2021-06-18",{"date":449,"type":21},"2026-12-31",{"name":38,"class":39},{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":17,"minAge":457,"maxAge":458,"enrollmentInfo":459,"targetDuration":4,"studyType":22,"phases":460,"briefSummary":461,"conditions":462,"keywords":466,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":468,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":473,"locationsCount":73},"100586878","assessment-of-the-effectiveness-of-virtual-reality-as-a-learning-tool-for-relaxation-techniques-in-reducing-pediatric-migraines-and-tension-type-headache-100586878","NCT06921109","Assessment of the Effectiveness of Virtual Reality as a Learning Tool for Relaxation Techniques in Reducing Pediatric Migraines and Tension Type Headache","Inclusion Criteria:\n\n* Having a history of headaches for at least 6 months, or having been diagnosed with migraines and\u002For chronic tension-type headaches according to the criteria of the International Headache Society (IHS) by a pediatric neurologist.\n\nExclusion Criteria:\n\n* having an epilepsy disorder","8 Years","15 Years",{"count":20,"type":21},[24],"The goal of this interventional study is to assess the efficacy of a therapeutic intervention aimed at diminishing pediatric chronic headache. This intervention is based on the development of relaxation skills, particularly the practice of deep breathing, using virtual reality in conjunction with a biofeedback device. Specifically, it aims to assess the relevance of this tool both in learning relaxation techniques and in changing cognitions involved in pain adjustment, such as self-efficacy and pain catastrophizing.\n\nThe main hypothesis is that the intervention using virtual reality will lead to greater daily use of the relaxation techniques learned, as well as an increase in the associated self-efficacy, resulting in a reduction in headaches (in terms of frequency and intensity) both immediately after the intervention and two months later.\n\nA secondary hypothesis is that this intervention will contribute to a decrease in negative pain perceptions, pain catastrophizing, and functional disability.\n\nA tertiary hypothesis is that the intervention will lead to an improvement in the child's quality of life.\n\nThe effects of this intervention will be compared to those of a similar intervention without the use of virtual reality, as well as to a control condition in which only psychoeducation is provided.",[463,464,465],"Chronic Headache","Migraine","Tension Type Headache",[252],"2025-04-07",{"date":444,"type":32},{"date":470,"type":32},"2024-12-13",{"date":472,"type":21},"2027-12-31",{"name":38,"class":39},{"id":475,"slug":476,"hasResults":12,"nctId":477,"briefTitle":478,"officialTitle":479,"acronym":4,"eligibilityCriteria":480,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":481,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":482,"conditions":483,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":467,"lastUpdatePostDateStruct":486,"startDateStruct":487,"completionDateStruct":489,"leadSponsor":491,"locationsCount":73},"100580334","impact-of-anesthesia-positive-pressure-ventilation-and-modality-of-imaging-on-the-echocardiographic-assessment-of-the-severity-of-aortic-regurgitation-100580334","NCT06835946","Impact of Anesthesia, Positive Pressure Ventilation and Modality of Imaging on the Echocardiographic Assessment of the Severity of Aortic Regurgitation","Prospective Single-center Observational Trial Aimed at Investigating the Effect of General Anesthesia, Positive Pressure Ventilation and Change of Imaging Modality From Transthoracic Echo to Transesophageal Echo on the Grading of the Severity of Aortic Regurgitation.","Inclusion Criteria:\n\n* Known aortic regurgitation of any grade\n* Scheduled for a cardiac surgery procedure during which a trans-esophageal echo is planned.\n\nExclusion Criteria:\n\n* Non sinus rhythm\n* Mitral regurgitation more than mild.\n* Pre-operative critical state (according to the definition of the EuroSCORE II)\n* Presence of a prosthetic aortic valve\n* Contra-indication to trans-esophageal echo",{"count":194,"type":21},"The goal of this observational study is to assess the impact of imaging modality (trans-thoracic echo (TTE) vs trans-esophageal echo (TEE)), anesthesia and positive pressure ventilation on the grading of aortic insufficiency.\n\nPatients scheduled for cardiac surgery and in whom a TEE is going to be performed intra-operatively will be enrolled. The grading of the aortic insufficiency will be compared between a TTE performed immediately before the induction of general anesthesia end the TEE performed after induction of general anesthesia.",[484,485],"Aortic Regurgitation Disease","Aortic Insufficiency",{"date":444,"type":32},{"date":488,"type":32},"2025-03-01",{"date":490,"type":21},"2027-04-01",{"name":38,"class":39},{"id":493,"slug":494,"hasResults":12,"nctId":495,"briefTitle":496,"officialTitle":497,"acronym":4,"eligibilityCriteria":498,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":499,"targetDuration":4,"studyType":22,"phases":500,"briefSummary":501,"conditions":502,"keywords":505,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":515,"locationsCount":73},"100416388","added-value-of-18-fdg-pet-scanner-in-diagnosis-and-management-of-subclinical-rejection-in-kidney-transplant-patients-100416388","NCT04702022","Added Value of 18 FDG Pet-scanner in Diagnosis and Management of Subclinical Rejection in Kidney Transplant Patients","Non-invasive Diagnosis and Management of Subclinical Rejection in Kidney Transplant Patients Using 18F-fluorodeoxy Glucose Positron Emission Tomography (18FDG-PET\u002FCT)","Inclusion Criteria:\n\n* Kidney recipients aged over 18 and of all sexes\n\nExclusion Criteria:\n\n* Pregnant patients\n* Polyomavirus nephropathy\n* Highly sensitised patients (historical or at 3 months Donor specific antibodies)\n* No corticosteroids withdrawal allowed (second kidney transplantation or primary disease)",{"count":331,"type":21},[24],"The renal biopsy (RB) represents the gold-standard for the diagnosis of acute renal transplant rejection (AR), and allows early verification of a so-called \"subclinical\" rejection, ie without any clinical or biological abnormality detectable in a stable kidney transplant patient. The RB also makes it possible to certify a strictly normal renal histology and thus to motivate the withdrawal of corticosteroid therapy. It is this 3-month post-transplant protocol RB protocol that has been effective since 2007 at the CHU Liège.\n\nHowever, RB is an invasive procedure, contraindicated in patients taking anticoagulants, and carrying a significant risk of complications. The potential complications associated with RB motivate the identification and validation of other diagnostic means. In the present project, the investigators propose to study the relevance of positron emission tomography (PET), coupled with conventional tomography (CT), after intravenous injection of 18-fluoro-deoxy-glucose (18FDG) in the overall protocol of the renal transplant patient at 3 months post-transplant to:\n\n(i) allow protocol renal biopsy only in patients with suspicion of an acute rejection (ii) be a decision maker for withdrawal from corticosteroids in the absence of rejection\n\nIn practice, the investigators suggest performing 18FDG PET \u002F CT imaging on the day of the surveillance biopsy, which is systematically performed in all kidney transplant patients at University Hospital of Liège 3 months after transplant. The investigators are considering 3 scenarios:\n\n* Scenario 1. The renal biopsy shows signs of humoral rejection: the patient is excluded from the study and is treated \"as usual\" on the basis of the histological results.\n* Scenario 2. The renal biopsy does not show signs of humoral rejection but the 18FDG PET \u002F CT shows a high metabolic activity of the graft (\\> 2.4): the patient is treated \"as usual\" on the basis of histological findings.\n* Scenario 3. The renal biopsy does not show signs of humoral rejection and the 18FDG PET \u002F CT shows a weak metabolic activity of the graft (\\\u003C2.4): the immunosuppressive treatment is gradually weaned off corticosteroids.\n\nThis clinical research project is interested in a major health problem in the follow-up of renal transplant patients, and could make it possible to improve the management of a subclinical rejection of the renal transplant and to increase the withdrawal of corticosteroids including side effects are well known.",[503,504],"Kidney Transplant Rejection","Kidney Transplant; Complications",[506,507,508],"PET\u002FCT imaging","Corticoids withdrawal","SubClinical Rejection","2025-04-06",{"date":511,"type":32},"2025-04-09",{"date":513,"type":32},"2021-01-04",{"date":319,"type":21},{"name":38,"class":39},{"id":517,"slug":518,"hasResults":12,"nctId":519,"briefTitle":520,"officialTitle":521,"acronym":4,"eligibilityCriteria":522,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":523,"targetDuration":4,"studyType":22,"phases":525,"briefSummary":526,"conditions":527,"keywords":531,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":538,"lastUpdatePostDateStruct":539,"startDateStruct":541,"completionDateStruct":543,"leadSponsor":544,"locationsCount":73},"100505944","psychoneurological-symptom-cluster-in-oncology-100505944","NCT05867966","Psychoneurological Symptom Cluster in Oncology","Evolution and Management of a Psychoneurological Symptom Cluster in Patients Who Had a Breast Cancer or a Digestive Cancer","Inclusion critera for WP1:\n\n* Diagnosis of non-metastatic breast cancer, or digestive cancer (i.e., anal, colorectal, gastric, esophageal, liver, pancreatic cancers).\n* ≥ 18 years old.\n* No history of cancer, and not currently in relapse.\n* Having completed the active treatments (i.e., surgery, chemotherapy, radiotherapy) for 5 years maximum, based on the methodology and recommendations of studies on symptom clusters in oncology\n\nAdditional inclusion criteria for WP2:\n\n* No history of severe psychiatric disorders (e.g., schizophrenia, dissociative episodes) or substance abuse (to avoid severe dissociation during hypnosis).\n* Score ≥ 4 for the core symptom selected to design the intervention, as suggest by previous interventional studies, and measured on a visual analogue scale from 0 to 10.",{"count":524,"type":21},500,[24],"A psychoneurological symptom cluster is increasingly documented in oncology. It is composed of cancer-related fatigue, sleep difficulties, pain, emotional distress, and cognitive difficulties. These symptoms are linked by strong but complex relationships, and reinforce each other, negatively impacting patients' quality of life and survival. The configuration of this cluster (i.e., the relationships between the symptoms) seems different according to the cancer diagnosis or moment in the cancer journey. It has however been very little studied. Network analysis is an innovative method that allows a deeper understanding of the interactions between these symptoms. It also allows to compare patterns of clustering between distinct populations or measurement times. Finally, it allows to determine one core symptom in a cluster (i.e., the one with the strongest associations with the other symptoms), which could represent a target of choice for interventions aiming to improve the whole symptom cluster. This innovative project has then two main goals. First, the investigators will assess the evolution of the psychoneurological symptom cluster in two populations of patients with cancer: women with breast cancer, and patients with digestive cancer, over two years. Second, the investigators will test the feasibility and preliminary benefits of a new mind-body group intervention specifically designed to address the core symptom of the cluster, determined with network analysis in each population. As suggested by many authors, the proposed intervention will be based on the common-sense model of self-regulation developed by Leventhal and focus on cognitive-behavioral, self-care and mind-body (i.e., hypnosis) empowering strategies. The aim is to assess the satisfaction of the participants regarding the intervention, as well as its impact on the symptoms involved in the cluster.",[528,529,530],"Cancer","Breast Cancer","Digestive Cancer",[532,533,534,535,536,537],"cancer","oncology","symptoms","quality of life","hypnosis","self-care","2025-03-18",{"date":540,"type":32},"2025-03-21",{"date":542,"type":32},"2024-01-16",{"date":472,"type":21},{"name":38,"class":39},{"id":546,"slug":547,"hasResults":12,"nctId":548,"briefTitle":549,"officialTitle":550,"acronym":551,"eligibilityCriteria":552,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":553,"enrollmentInfo":554,"targetDuration":4,"studyType":22,"phases":556,"briefSummary":557,"conditions":558,"keywords":4,"overallStatus":28,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":561,"completionDateStruct":563,"leadSponsor":565,"locationsCount":422},"100584011","effects-of-virtual-reality-hypnosis-on-anxiety-pain-and-comfort-in-oncology-patients-during-a-port-catheter-placement-procedure-100584011","NCT06883786","Effects of Virtual Reality Hypnosis on Anxiety, Pain and Comfort in Oncology Patients During a Port-catheter Placement Procedure","Interest of Virtual Reality Hypnosis to Decrease Anxiety, Pain, and Discomfort of Patients With Cancer Having to Undergo an Invasive Intervention","VRH-PAC","Inclusion Criteria:\n\n* Low auditory and\u002For visual acuity precludes the use of the device.\n* Head or face wounds precluding the use of the device.\n* Schizophrenia, dissociative disorder or any other psychiatric disorder.\n* Non-proficiency in French (Research language).\n* Patient under 18 years old.\n* Phobia of deep water.\n* Dizziness.","90 Years",{"count":555,"type":21},102,[24],"The port-catheter (PAC) is a longterm venous access device, frequently used in oncology patients. The PAC is an invasive technique, consisting of a reservoir surgically implanted in the chest wall or upper arm, and arm and a catheter. Patients can experience pain in the incision area after implantation, as well as anxiety before, during and after implantation. Virtual reality hypnosis (VRH) is an innovative technique delivering clinical hypnosis to patients through virtual reality (VR). The clinical applications of VRH are still little known. We will assess the anxiety, comofrt, pain perception and pain unpleasantness of 102 cancer patients scheduled to receive a PAC. The patients will be randomly divided into two groups. Thefirst group will benefit from the usual care for the placement of the PAC (i.e., local anaesthesia), while the second will benefit from the VRH in addition to the usual care. Pain perception, pain unpleasantness, anxiety, satisfaction, absorption, dissociation will be evaluated before and after the intervention.",[528],"2025-03-12",{"date":418,"type":32},{"date":562,"type":21},"2025-04",{"date":564,"type":21},"2027-02",{"name":38,"class":39},{"id":567,"slug":568,"hasResults":12,"nctId":569,"briefTitle":570,"officialTitle":571,"acronym":4,"eligibilityCriteria":572,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":573,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":574,"conditions":575,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":470,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":580,"leadSponsor":582,"locationsCount":73},"100417291","bone-density-and-vascular-calcifications-evolution-after-renal-transplant-100417291","NCT04713774","Bone Density and Vascular Calcifications Evolution After Renal Transplant","Evolution of Bone Density, Bone Micro-architecture and Vascular Calcifications in Patients After Kidney Transplantation","Inclusion Criteria:\n\n* At least 18 years old\n* Recent kidney transplant patients (\\\u003C3 months)\n* Medical history available\n* Biological parameters of the past year available\n\nExclusion Criteria:\n\n* Treatment with bisphosphonate, RANKL inhibitor or SERM with bone action in the last 3 months before the transplant\n* Multiple organ transplant patients",{"count":331,"type":21},"The investigators project is based on:\n\n* Assessment of bone architecture by high resolution peripheral scanner (HRpQCT) and bone densitometry (DEXA);\n* The non-invasive detection of vascular calcifications (by abdominal CT scanner) and bone abnormalities associated with kidney transplantation, as well as the analysis of evolution over time;\n* Longitudinal evaluation of nephrological clinical parameters (glomerular filtration rate, number and type of rejections, immunosuppressive medications) as well as biological and urinary parameters of mineral metabolism (parathormone, sclerostin, bone alkaline phosphatase) depending on the type and severity of bone abnormalities;\n* The evaluation of these nephrological clinical parameters and of the biological parameters of mineral metabolism depending on the extent and evolution of vascular calcifications but also on bone morphology;\n* The study of possible relationships between bone mass and muscle mass (and functioning)",[504,576],"Bone Loss",{"date":578,"type":32},"2024-12-18",{"date":202,"type":32},{"date":581,"type":21},"2026-12-13",{"name":38,"class":39},{"id":584,"slug":585,"hasResults":12,"nctId":586,"briefTitle":587,"officialTitle":588,"acronym":589,"eligibilityCriteria":590,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":591,"targetDuration":4,"studyType":22,"phases":592,"briefSummary":594,"conditions":595,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":597,"lastUpdatePostDateStruct":598,"startDateStruct":600,"completionDateStruct":602,"leadSponsor":603,"locationsCount":73},"100354923","phase-1-msc-intratissular-injection-in-crohn-disease-patients-100354923","NCT03901235","MSC Intratissular Injection in Crohn Disease Patients","Treatment of Refractory Crohn's Disease Lesions by Local Injection of Mesenchymal Stem Cells","MSC","Inclusion Criteria:\n\n* Patients ≥ 18 years of age\n* Signing the informed consent\n* Diagnosis of Crohn Disease for more than 6 months\n* Presence of at least one Crohn Disease lesion refractory to conventional therapies (azathioprine, 6-mercaptopurine or methotrexate) and to biologic treatments (anti-Tumor Necrosis Factor therapies, vedolizumab, or ustekinumab).\n* Refractory lesion defined by (1) a stricture with a length of 2 to 5cm of the colon or the ileum accessible by ileocolonoscopy (i.e. a lesion identified during a colonoscopy with a lumen narrowing non passable by the colonoscope), (2) unhealed deep ulcer of the colon or the ileum accessible to ileocolonoscopy, or (3) actively draining perianal fistula(s).\n* Twenty patients with stricture(s), 20 patients with unhealed deep ulcer(s), and 20 patients with an actively draining perianal fistula(s) will be included\n\nExclusion Criteria:\n\n* Indication for immediate luminal surgery\n* Intestinal obstruction\n* Intra-abdominal fistulas or abscess\n* Intestinal\u002Fcolonic stricture or deep unhealed ulcer not accessible to ileocolonoscopy\n* Undrained peri-anal abscess\n* Pregnant women or planning pregnancy within one year\n* Positive stool culture\u002Ftoxin for clostridium difficile pathogen or other pathogens\n* Renal failure (anuria, serious fluid overload, Glomerular Filtration Rate \\\u003C 30 ml\u002Fmin, dialysis) or hepatic failure (Fulminant liver failure, cirrhosis of the liver with evidence of portal hypertension, alcoholic hepatitis, esophageal varices, a history of bleeding esophageal varices, hepatic encephalopathy, uncorrectable hepatic synthetic dysfunction evinced by prolongation of the prothrombin time, ascites related to portal hypertension, bacterial or fungal liver abscess, biliary obstruction, chronic viral hepatitis with total serum bilirubin \\>3 mg\u002FdL)\n* documented human immunodeficiency virus infection; active hepatitis B, C, or tuberculosis\n* an opportunistic infection within 6 months before screening or a serious infection in the previous 3 months\n* malignancy within the past 5 years; or a history of lymphoproliferative disease",{"count":20,"type":21},[593,434],"PHASE1","The main objective is to assess the efficacy of local injection of MSC on the healing of refractory intestinal and perianal lesions in crohn disease. The second co-primary endpoint is safety.",[596],"Efficacy and Safety","2024-12-06",{"date":599,"type":32},"2024-12-12",{"date":601,"type":32},"2018-01-15",{"date":449,"type":21},{"name":38,"class":39},{"id":605,"slug":606,"hasResults":12,"nctId":607,"briefTitle":608,"officialTitle":608,"acronym":4,"eligibilityCriteria":609,"healthyVolunteers":132,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":610,"targetDuration":4,"studyType":85,"phases":4,"briefSummary":611,"conditions":612,"keywords":617,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":619,"lastUpdatePostDateStruct":620,"startDateStruct":622,"completionDateStruct":624,"leadSponsor":626,"locationsCount":73},"100543949","incidence-of-episodes-of-disconnected-consciousness-among-emergency-patients-admitted-in-the-resuscitation-room-100543949","NCT06362525","Incidence of Episodes of (Dis)Connected Consciousness Among Emergency Patients Admitted in the Resuscitation Room","Inclusion Criteria:\n\n* patients admitted in the resuscitation room of our university hospital\n* French speaking\n\nExclusion Criteria:\n\n* Refusal\n* Chronic disorder of consciousness\n* Deafness\n* Blindness\n* Dementia\n* Hemineglect\n* Aphasia",{"count":194,"type":21},"This observational study aims to describe the incidence of episodes of disconnected consciousness (including near-death experience (NDE)) and episodes of connected consciousness in patients admitted to the resuscitation room, who survived a critical condition and who meet at least one of these criteria during their stay in the resuscitation room: (1) deep sedation, (2) intubation, (3) cardiopulmonary resuscitation, or (4) (non-drug-induced) Glasgow Coma Scale score = 3. We also investigate the potential (neuro)physiological markers and biomarkers. In order to help determine the potential risk factors of such episodes, cognitive factors such as dissociative propensity are also investigated. Unexpected visual and auditory stimuli will be displayed. In addition, we assess the evolution of memory, as well as short- and long-term consequences on quality of life, anxiety, and attitudes towards care.\n\nMemory of patients who did not meet the above-mentioned criteria are also investigated. A group of 15 healthy participants will be invited to test the stimuli display.\n\nFinally, (neuro)physiological parameters of a subsample of dying patients are also investigated.",[359,613,614,615,616],"Near-Death Experience","Consciousness, Loss of","Quality of Life","Emergencies",[618],"Dream","2024-04-08",{"date":621,"type":32},"2024-04-12",{"date":623,"type":32},"2023-10-09",{"date":625,"type":21},"2027-09-30",{"name":38,"class":39},{"id":628,"slug":629,"hasResults":12,"nctId":630,"briefTitle":631,"officialTitle":631,"acronym":4,"eligibilityCriteria":632,"healthyVolunteers":132,"sex":17,"minAge":457,"maxAge":4,"enrollmentInfo":633,"targetDuration":4,"studyType":22,"phases":635,"briefSummary":636,"conditions":637,"keywords":4,"overallStatus":64,"whyStopped":4,"lastUpdateSubmitDate":639,"lastUpdatePostDateStruct":640,"startDateStruct":642,"completionDateStruct":644,"leadSponsor":646,"locationsCount":73},"100319152","a-hypnosis-based-group-intervention-to-improve-quality-of-life-in-children-with-cancer-and-their-parents-100319152","NCT03435042","A Hypnosis-based Group Intervention to Improve Quality of Life in Children With Cancer and Their Parents.","Inclusion Criteria:\n\n* Children and their siblings:\n\n  * To be 8 to 18 year-old\n  * To suffer from cancer (all localisations, stage and treatments accepted) or to have a sibling who suffer from cancer\n  * To speak french\n* Parents:\n\n  * To have a child who suffer from cancer\n  * To speak french\n\nExclusion Criteria:\n\n* \u002F",{"count":634,"type":21},30,[24],"Background: A lot of children with cancer suffer from emotional distress, fatigue and relational difficulties. Their parents are also impacted by the disease: their responsibilities increase and they can feel more distressed and tired. Different psychological interventions designed for ill children and their parents seem to be efficient to improve their social functioning, coping strategies and well-being. However, more research is needed in this field. Hypnosis is often used in paediatric oncology, mostly to decrease procedure-related pain and distress. It has been used efficiently to improve the well-being of adults with cancer. This paper describes a pilot study designed to assess the feasibility and interest of a group intervention combining self-care and hypnosis for children with cancer and their parents, and a quasi-experimental protocol aimed at assessing the efficacy of this group intervention to improve the quality of life of children and their parents.\n\nMethods: Our pilot study showed that our intervention was feasible and positive for the participants. To test the efficacy of the intervention, two groups will be set up: one with children with cancer and their interested siblings, and one with their parents. Data will be collected for each group before and after the intervention by questionnaires and a semi-structured interview.\n\nDiscussion: There is a growing interest in hypnosis in oncology settings. The results of this study should improve knowledge about the efficacy of a group intervention combining self-care and hypnosis to improve quality of life of children with cancer and their family.",[638],"Pediatric Cancer","2023-06-29",{"date":641,"type":32},"2023-07-03",{"date":643,"type":32},"2018-01-25",{"date":645,"type":21},"2028-12-31",{"name":38,"class":39},""]