[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Lisbon\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":148},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,53,83,116],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":32,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":52},"100614176","ul-smile-a-mobile-health-application-to-promote-oral-health-in-portuguese-adolescents-100614176",false,"NCT07276191","UL Smile: A Mobile Health Application to Promote Oral Health in Portuguese Adolescents","UL Smile - Mobile Application for Oral Health Promotion: Development and Effectiveness Evaluation in Adolescents Living in Portugal: A Randomized Controlled Field Trial","UL Smile","Inclusion Criteria:\n\n* Be aged between 15 and 18 years at baseline.\n* Be fluent in Portuguese.\n* Have access to a mobile phone or computer\u002Ftablet with internet.\n* Be willing to participate in the study by providing signed assent\u002Fconsent. For participants under 18 years old, consent must be signed by a legal guardian.\n* Use of the app at least twice during the first month of the study.\n\nExclusion Criteria:\n\n* Current or previous use of any oral health-related mobile application.\n* Not being responsible for their own oral hygiene.",true,"ALL","15 Years","19 Years",{"count":22,"type":23},150,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study is part of a doctoral research project in Oral Health Sciences and Technologies, with a specialization in Dental Hygiene, at the Faculty of Dental Medicine, University of Lisbon.\n\nWith the advancement of technology, smartphones and mobile applications (apps) have become an integral part of daily life, especially among adolescents and young adults, who are the main users of these devices. In 2023, global app downloads reached an estimated 257 billion, including a growing number of health-related apps, known as Mobile Health or mHealth, and, more specifically, apps targeting oral health.\n\nOral diseases, such as dental caries and periodontal disease, remain a major public health issue due to their high prevalence and impact on quality of life. Although these conditions are preventable, the adoption and maintenance of healthy behaviors continues to be challenging. Mobile apps may serve as an effective complement to oral health consultations, promoting motivation, adherence to recommendations, and communication with healthcare professionals.\n\nDespite the increasing availability of oral health apps, evidence regarding their effectiveness is still limited. Many of these tools lack scientific rigor and fail to adequately meet users' needs.\n\nIn this context, an original Portuguese-language mobile application for promoting oral health was developed, based on current scientific evidence and preliminary exploratory studies involving adolescents and oral health professionals. These studies aimed to identify the most relevant features for this type of tool. The app was designed using the Behaviour Change Wheel (BCW) model, widely recognized for structuring effective behavior change interventions in health.\n\nThis mobile app was developed by a multidisciplinary team from the University of Lisbon, involving experts from various faculties, including Psychology, Sciences, Dental Medicine, and Fine Arts. As an original tool, it is not yet available on app stores.\n\nThe main aim of this study is to test the effectiveness of this app as a complement to oral health consultations in a population of adolescents living in Portugal, contributing to the advancement of knowledge in this field and to the promotion of more innovative and user-centered clinical practices.\n\nThese are the specific objectives of the study:\n\n1. To assess the effectiveness of the app when used as a complement to dental hygiene consultations in relation to several oral health indicators, namely risk of dental caries, gingival inflammation, dental plaque presence, and oral self-care behaviors.\n2. To analyze the level of satisfaction and usability of the app's features.\n\nThe main hypotheses are:\n\n1. The app will significantly improve oral health indicators, including plaque levels, gingival inflammation, and caries risk, compared to a control group.\n2. The app will increase adherence to recommended oral hygiene behaviors (e.g., brushing frequency, interdental cleaning).\n3. Adolescents using the app will report higher motivation and self-efficacy for oral self-care.\n4. The app will demonstrate high usability and user satisfaction, supporting its potential for broader implementation.",[29,30,31],"Oral Health Care","Oral Health Behavior Change","Oral Health Self-efficacy",[33,34,35,36,37,38,39],"Adolescent","Mobile Applications","Oral Health","Health Promotion","MHealth","Health Behavior","Behavior change techniques","RECRUITING","2026-01-30",{"date":43,"type":44},"2026-02-03","ACTUAL",{"date":46,"type":23},"2026-02-02",{"date":48,"type":23},"2026-12-31",{"name":50,"class":51},"University of Lisbon","OTHER",1,{"id":54,"slug":55,"hasResults":11,"nctId":56,"briefTitle":57,"officialTitle":57,"acronym":58,"eligibilityCriteria":59,"healthyVolunteers":11,"sex":18,"minAge":60,"maxAge":4,"enrollmentInfo":61,"targetDuration":4,"studyType":63,"phases":4,"briefSummary":64,"conditions":65,"keywords":69,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":52},"100616743","regional-versus-general-anesthesia-for-hip-fracture-and-postoperative-oxygenation-100616743","NCT07309575","Regional Versus General Anesthesia for Hip Fracture and Postoperative Oxygenation","REGENERATION","Inclusion Criteria:\n\n* hospital admission for hip fracture;\n* scheduled for hip fracture surgery;\n* age above 65 years, both genders;\n* capable of consent or consent by responsible person;\n\nExclusion Criteria:\n\n* hip fracture during hospitalization (not present upon admission)\n* patient refusal to participate","65 Years",{"count":62,"type":23},102,"OBSERVATIONAL","With this study, the investigators intend to measure oxygen saturation before and after hip surgery in the context of proximal femur fracture, comparing two types of anesthesia (general or spinal). The investigators also intend to study the effects of the two anesthetic techniques on sleep apnea, delirium, respiratory complications, and length of hospital stay.\n\nThis is an observational study, in which oxygen is measured at the fingertip with a sensor and a bracelet, without any intervention, inconvenience, or discomfort for the participant. Data will be collected on: respiratory complications, sleep apnea, delirium, length of hospital stay, and survival.\n\nData will be collected in the operating room and wards of Santa Maria Hospital, Lisbon, Portugal over a period of approximately 24 hours after the participant's operation. Information about participant's health and co-morbidities will be recorded.\n\nThere will be no implication for the participants' clinical care, since the study measurements will not be sent to the health professionals in charge. The operation, recovery, and treatments will not be influenced at any time by participation in the study.",[66,67,68],"Hip-fracture","General Anaesthesia","Regional Anaesthesia",[70,71,72,73,74],"anaesthesia","hip femur fracture","postoperative pulmonary complications","oxygenation","sleep apnea","2025-12-19",{"date":77,"type":44},"2025-12-30",{"date":79,"type":44},"2025-11-27",{"date":81,"type":23},"2026-12",{"name":50,"class":51},{"id":84,"slug":85,"hasResults":11,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":4,"eligibilityCriteria":89,"healthyVolunteers":11,"sex":90,"minAge":91,"maxAge":4,"enrollmentInfo":92,"targetDuration":4,"studyType":24,"phases":94,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":108,"lastUpdatePostDateStruct":109,"startDateStruct":111,"completionDateStruct":113,"leadSponsor":115,"locationsCount":52},"100552386","a-women-focused-cardiovascular-rehabilitation-program-on-adherence-health-related-physical-fitness-and-quality-of-life-100552386","NCT06472414","A Women-Focused Cardiovascular Rehabilitation Program on Adherence, Health Related Physical Fitness, and Quality of Life","Effects of a Women-Focused Maintenance Cardiovascular Rehabilitation Program on Adherence, Health Related Physical Fitness, and Quality of Life: a Randomized Controlled Trial","Inclusion Criteria:\n\n* Documented cardiovascular disease: angiographically documented coronary artery disease in at least one major epicardial vessel; those that had clinical evidence of coronary artery disease in the form of previous myocardial infarction; or coronary revascularization (coronary artery bypass grafting or percutaneous coronary intervention); heart failure, including cardiac transplantation; heart valve surgery or percutaneous implantation of prosthetic valves or clips; left ventricular assist or resynchronization devices, defibrillators or pacemakers; congenital heart disease.\n* After phase II cardiovascular rehabilitation program completion or after 6 months of cardiovascular disease diagnosis if no phase II was performed.\n* Clinically stable and with no contraindications to exercise training.\n\nExclusion Criteria:\n\n* Inability to comply with guidelines for exercise testing\u002Ftraining.\n* Inability to give informed consent.\n* Significant limiting and\u002For unstable co morbidities, such as arthritis, metabolic disorders, visual, cognitive, or serious mental illness.","FEMALE","18 Years",{"count":93,"type":23},82,[26],"Cardiovascular disease (CVD) remains leader of global causes of death worldwide and recent documented trends show a rise in acute myocardial infarction in younger women. Compared to men, women have a higher cardiovascular risk due to hypertension, dyslipidaemia, diabetes mellitus, obesity, physical inactivity, and a sedentary lifestyle. Plus, they have additional sex-specific cardiovascular risk factors such as gestational hypertension\u002Fdiabetes, preterm delivery, premature menopause, and polycystic ovary syndrome.\n\nCardiovascular rehabilitation (CR) is a Class I, level A, clinical practice guideline recommendation, multidisciplinary secondary prevention program that has been shown to reduce cardiovascular mortality, rehospitalization, and improve quality of life. Despite all established benefits, CR continues to be under referred to women compared to men, with lower enrolment rates and lower adherence to exercise sessions. The reasons for the underuse of CR by women and the main barriers have been widely studied. Thus, sex-specific implementation strategies have been developed to improve adherence, however, the efficacy claims of these interventions are equivocal, as some studies revealed no significative difference regarding adherence between different exercise delivery modes and mixed-sex programs, whereas others revealed greater preference towards women-only programs.\n\nFew randomized controlled trials (RCT) examined the efficacy of CR programs tailored to women in adherence, enrolment, functional capacity, physical activity, body composition, and quality of life. Importantly, to the investigators knowledge, no RCTs used counselling sessions, women-focused educational sessions, personalized follow-ups and supervised exercise sessions as adherence strategies in maintenance CR community programs.\n\nThe goal of this RCT is to test whether a women-focused maintenance CR community program increases adherence compared to a standard care. Thus, the investigators hypothesized that:\n\n• The women-focused group will have greater adherence to the CR community program (main outcome)\n\nParticipants will:\n\n* Be assessed at baseline, at 3-months and at 6-months\n* Enrol in a supervised community-based maintenance CR program\n* Receive individually prescribed exercise sessions (both groups), a tailored package consisting of individual counselling sessions and educational sessions (women-focused group)",[97],"Cardiovascular Diseases",[99,100,101,102,103,104,105,106,107],"Secondary Prevention","Phase III","Personalized","Physical activity counselling","Supervised","Exercise training","Women","Goal-oriented","Long Term","2025-01-24",{"date":110,"type":44},"2025-01-28",{"date":112,"type":44},"2024-10-08",{"date":114,"type":23},"2027-04",{"name":50,"class":51},{"id":117,"slug":118,"hasResults":11,"nctId":119,"briefTitle":120,"officialTitle":120,"acronym":121,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":18,"minAge":123,"maxAge":91,"enrollmentInfo":124,"targetDuration":4,"studyType":24,"phases":126,"briefSummary":127,"conditions":128,"keywords":135,"overallStatus":139,"whyStopped":4,"lastUpdateSubmitDate":140,"lastUpdatePostDateStruct":141,"startDateStruct":143,"completionDateStruct":145,"leadSponsor":147,"locationsCount":4},"100556108","treatment-and-handling-severe-obesity-related-comorbidities-in-adolescents-through-exercise-100556108","NCT06520800","Treatment and Handling Severe Obesity-Related Comorbidities in Adolescents Through Exercise","THOR-X","Inclusion Criteria:\n\n* adolescents aged 13 to 18 years;\n* of any gender (including transgender adolescents);\n* with severe obesity (≥3.0 BMI z-score) \\[24\\];\n* with any obesity-related comorbidity (e.g., hypertension, IR or DMT2, dyslipidemia, eating disorders, depression\u002Fanxiety);\n* at least 6 months of follow-up at the Pediatric Obesity Clinic (HSM, CHULN) at the time of recruitment;\n* living in Lisbon area;\n* informed consent\u002Fassent signature.\n\nExclusion Criteria:\n\n* major or unstable clinical conditions (other than obesity or its related comorbidities);\n* inability to perform regular PA;\n* pregnancy;\n* mental disorders;\n* smoking habits;\n* being involved in another weight loss program.","13 Years",{"count":125,"type":23},24,[26],"The main objective of this project is to analyze the effect of a tailor-made, one-to-one, exercise program (aiming to treat and handle obesity-related comorbidities in adolescents with severe obesity at high risk of cardiovascular disease development) on BMI z-score, specific comorbidities, and other health-related indicators.\n\nThis project will further allow to analyze the long-term impact of the exercise program not only on clinical parameters, but also on the interaction with drug-treatment, health-related behaviors, and quality of life, further contributing to the understanding of the individual characteristics associated with a positive exercise response and frequency.\n\nThe secondary objective of the THOR-X project is to build an educational toolkit, based on project results and relevant literature, addressed to health and exercise professionals, in order to improve management of adolescents with obesity, in particular those with severe obesity.",[129,130,131,132,133,134],"Adolescent Obesity","Hypertension,Essential","Non-Alcoholic Fatty Liver Disease","Dyslipidemias","Metabolic Disease","Metabolic Syndrome",[129,136,137,138],"Obesity treatment","Physical activity","Exercise","NOT_YET_RECRUITING","2024-07-25",{"date":142,"type":44},"2024-07-29",{"date":144,"type":23},"2025-01",{"date":146,"type":23},"2028-12",{"name":50,"class":51},""]