[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Ljubljana\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":327},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,12,0,[8,49,85,120,143,169,188,213,233,265,285,308],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100644142","polarized-aerobic-training-and-vascular-adaptations-in-apparently-healthy-individuals-100644142",false,"NCT07665632","Polarized Aerobic Training and Vascular Adaptations in Apparently Healthy Individuals","Adaptations of Vascular and Cardiorespiratory Function to a 6-week Polarized Aerobic Training Model in Apparently Healthy Individuals","ACT-ON-CHRONIC","Inclusion Criteria:\n\n* Men and women aged 30-50 years\n* Apparently healthy individuals without diagnosed cardiovascular, metabolic, or renal disease\n* Sedentary lifestyle verified using the Global Physical Activity Questionnaire (GPAQ) and current physical activity classification criteria\n* Ambulatory blood pressure values within the normotensive range (\\\u003C140 mmHg systolic and \\\u003C90 mmHg diastolic)\n* Body mass index (BMI) \\\u003C30 kg\u002Fm²\n* No regular participation in structured exercise training\n\nExclusion Criteria:\n\n* Ambulatory blood pressure values ≥140 mmHg systolic and\u002For ≥90 mmHg diastolic\n* Moderate or high physical activity level according to the Global Physical Activity Questionnaire (GPAQ)\n* Diagnosed chronic cardiovascular, metabolic, renal, respiratory, or other systemic disease\n* Use of prescribed medication influencing cardiovascular or metabolic function\n* Musculoskeletal injury of the lower extremities within the previous six months\n* Menopause\n* Absence of a regular menstrual cycle\n* Pregnancy\n* Current smoking or tobacco use",true,"ALL","30 Years","50 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","This randomized controlled trial will investigate the effects of a 6-week polarized aerobic training intervention on vascular and cardiorespiratory function in apparently healthy sedentary adults aged 30-50 years. Polarized training is characterized by a high proportion of low-intensity aerobic exercise combined with a smaller volume of high-intensity interval exercise, potentially providing complementary haemodynamic and physiological stimuli that support vascular adaptations and cardiovascular health. Although polarized training has been extensively studied in athletic populations, its effects on vascular function in sedentary adults remain insufficiently understood.\n\nThirty participants will be randomly assigned in a 1:1 ratio to either a supervised polarized aerobic training group or a non-exercising control group. The intervention will consist of a 6-week supervised cycle ergometer training program performed three times per week and prescribed according to individual ventilatory thresholds obtained during cardiopulmonary exercise testing. Training sessions will combine low-to-moderate-intensity continuous exercise and high-intensity interval exercise. Participants allocated to the control group will maintain their habitual sedentary lifestyle throughout the study period.\n\nThe primary outcome will be endothelial function assessed by brachial artery flow-mediated dilation. Secondary outcomes will include arterial stiffness assessed by pulse wave velocity, central haemodynamics, microvascular function, cardiorespiratory fitness, skeletal muscle function, pulmonary function, respiratory muscle strength, and circulating biomarkers related to vascular health. Outcome measures will be assessed at baseline and after completion of the 6-week intervention period. The findings of this study may improve understanding of vascular and systemic adaptations to polarized aerobic training and help inform future exercise-based strategies for cardiovascular risk reduction in apparently healthy sedentary adults.",[29],"Sedentary Lifestyle",[31,32,33,34,35],"Polarized training","Vascular function","Flow-mediated dilation","Pulse wave velocity","Randomized controlled trial","RECRUITING","2026-06-17",{"date":39,"type":40},"2026-06-24","ACTUAL",{"date":42,"type":23},"2026-05-25",{"date":44,"type":23},"2027-12-20",{"name":46,"class":47},"University of Ljubljana","OTHER",1,{"id":50,"slug":51,"hasResults":11,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":20,"enrollmentInfo":58,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":65,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100611187","peripheral-magnetic-stimulation-of-foot-muscles-effects-on-medial-longitudinal-arch-height-and-foot-muscle-strength-in-adults-with-flat-feet-100611187","NCT07237321","Peripheral Magnetic Stimulation of Foot Muscles: Effects on Medial Longitudinal Arch Height and Foot Muscle Strength in Adults With Flat Feet","Peripheral Magnetic Stimulation of Foot Muscles","rPMS-Foot","Inclusion Criteria:\n\n* Age between 18 and 50 years,\n* functionally flat feet of participants.\n\nExclusion Criteria:\n\n* Acute leg injuries,\n* diabetes,\n* vascular disorders of the lower limbs,\n* open wounds or skin lesions on the lower leg or foot,\n* participants with metal implants near the stimulation site,\n* cardiac pacemaker,\n* other orthopedic or neurological conditions that could affect the study results or pose a health risk to the participants.","18 Years",{"count":22,"type":23},[26],"This study examines the effects of repetitive peripheral magnetic stimulation (rPMS) on foot invertor muscle strength, morphology, and the height of the medial longitudinal arch (MLA) in individuals with flat feet. The rPMS will be applied non-invasively to the extrinsic and intrinsic foot muscles three times per week for twelve weeks. The experimental group will receive rPMS targeting the invertor muscles of the foot, while the control group will not receive stimulation but will follow the same measurement schedule.\n\nAssessments will be performed at baseline, after 6 weeks, and after 12 weeks of intervention. The primary outcome will be the change in the height of the MLA, evaluated using dynamic navicular drop assessment during gait. Secondary outcomes will include changes in the isometric inversion torque of the foot invertors and morphological adaptations of the tibialis posterior muscle assessed by ultrasound imaging.\n\nThis study seeks to determine whether rPMS can improve the height of the MLA, foot invertor muscle strength and structural stability in adults with flat feet. The findings may contribute to developing new, non-invasive therapeutic approaches for improving foot function and preventing musculoskeletal imbalances related to flat foot deformity.",[62,63,64],"Pes Planus","Flatfoot","Posterior Tibial Tendon Dysfunction",[66,63,67,68,69,70,71,72,73,74,75],"Medial Longitudinal Arch","rPMS","foot invertors","tibialis posterior","repetitive peripheral magnetic stimulation","foot","posterior tibial tendon dysfunction","strength","ultrasound","muscle cross-sectional area","2026-05-30",{"date":78,"type":40},"2026-06-02",{"date":80,"type":40},"2025-12-16",{"date":82,"type":23},"2027-12-31",{"name":46,"class":47},2,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":95,"conditions":96,"keywords":99,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":112,"lastUpdatePostDateStruct":113,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":48},"100567555","evaluation-of-physical-fitness-and-hemodynamics-across-a-diverse-population-100567555","NCT06669715","Evaluation of Physical Fitness and Hemodynamics Across a Diverse Population","Validation of an Interval Test for Monitoring Cardiovascular Function for Individuals With Different Levels of Physical Fitness","ACT-ON-s1","Inclusion Criteria:\n\n* Adults (18 + years of age) without restriction on sex, health status or physical fitness.\n\nExclusion Criteria:\n\n* Inability to walk without assistance\n* Presence of acute injuries and\u002For illnesses that limit maximal exertion during physical fitness testing\n* Lower extremity injury or surgery within the past 2 years (if not fully rehabilitated)",{"count":22,"type":23},"OBSERVATIONAL","In this study, investigators will use the IFT 30-15 test, a six-minute walking test, and a treadmill test to assess the participants' cardiorespiratory fitness. For the treadmill cardiopulmonary exercise test (CPET), we will measure indirect gas exchange using a CPET device (K5). Maximum heart rate (HRmax) will be measured with a Polar heart rate monitor (model H10). The six-minute walking test will follow standardized procedures, and the treadmill test will follow a protocol of gradually increasing speed each minute.\n\nThe study will involve two groups of participants: healthy individuals and pre-hypertensive individuals. While the IFT 30-15 test has been validated on a diverse range of athletes and physically active individuals, it has not yet been validated in individuals with similar characteristics to our participants (BMI \\> 30 and limited cardiovascular function). Additionally, a variety of hemodynamic measures and other physical function measures such as sit-to-stand and push-ups will be assessed for all participants.",[97,98],"Prehypertension (Elevated Blood Pressure) or Hypertension","Obesity and Obesity-related Medical Conditions",[100,101,102,103,104,105,106,107,108,109,110,111],"cardiovascular fitness","CRF","physical fitness testing","vascular function","heamodynamics","blood pressure","prehypertension","aerobic capacity","arterial stiffness","endothelial function","post-occlusive reactive hyperemia","PORH","2026-05-07",{"date":114,"type":40},"2026-05-12",{"date":116,"type":40},"2024-11-04",{"date":118,"type":23},"2027-10-30",{"name":46,"class":47},{"id":121,"slug":122,"hasResults":11,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":128,"enrollmentInfo":129,"targetDuration":4,"studyType":24,"phases":131,"briefSummary":132,"conditions":133,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":48},"100569310","electrolysed-saline-rinse-as-an-adjunct-for-treatment-of-chronic-periodontitis-100569310","NCT06692582","Electrolysed Saline Rinse as an Adjunct for Treatment of Chronic Periodontitis","Influence of Adjunctive Electrolysed Saline Rinse in Stage III Periodontitis Patients","EOSPERIO","Inclusion Criteria:\n\nClinical attachment loss ≥ 5 mm on at least two teeth in two different jaw quadrants; presence of stable occlusion and at least 16 teeth, among which at least 12 teeth are suitable for evaluation (excluding wisdom teeth, teeth with orthodontic wires, bridges, crowns, and implants).\n\nExclusion Criteria:\n\nWe will exclude individuals who: suffer from chronic systemic diseases (diabetes, cancer, HIV infection, metabolic bone diseases, and diseases that interfere with wound healing processes); are undergoing radiation or chemotherapy; are taking immunosuppressants, antiepileptic drugs, calcium antagonists, nonsteroidal anti-inflammatory drugs; have been treated with antibiotics in the past 12 months; have a known allergy to CHX; have undergone scaling and root planing or surgical periodontal treatment in the past year; are pregnant or breastfeeding.","80 Years",{"count":130,"type":23},60,[26],"The study will be conducted as a prospective, double-blind, parallel, randomized, placebo-controlled study at the Dental Clinic of University Medical Centre Ljubljana. It will involve a one-month test period, during which the test subjects will use either placebo, Electrolysed Oxidising Saline (EOS) or chlorhexidine (CHX) in the form of a mouthwash as an adjunct to the non-surgical treatment of chronic periodontitis (i.e. root planing and scaling). The study will include 60 subjects selected from consecutively scheduled patients referred by their personal dentists for periodontal treatment at the Dental Clinic of University Medical Centre Ljubljana.",[134],"Periodontitis","2026-05-05",{"date":137,"type":40},"2026-05-11",{"date":139,"type":40},"2024-06-06",{"date":141,"type":23},"2026-12-06",{"name":46,"class":47},{"id":144,"slug":145,"hasResults":11,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":17,"sex":18,"minAge":151,"maxAge":4,"enrollmentInfo":152,"targetDuration":4,"studyType":24,"phases":154,"briefSummary":155,"conditions":156,"keywords":158,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":48},"100517017","two-piece-zirconia-implants-with-two-various-platforms-100517017","NCT06012071","Two-piece Zirconia Implants With Two Various Platforms","Comparison of Two-piece Zirconia Implants With Tissue-level and Bone-level Platform: Randomized Controlled Clinical Trial","ZircImpl","Inclusion Criteria:\n\n* Single missing maxillary premolar\n* Occlusal stability\n* Good oral hygiene\n* Good general health\n\nExclusion Criteria:\n\n* Oral mucosa pathology\n* Dental caries\n* Active periodontitis (non-treated)\n* Systemic diseases and conditions that affect healing or immune capacity","25 Years",{"count":153,"type":23},24,[26],"24 patients with missing premolar teeth and healed sockets will be recruited. They will be randomized into two groups to supplied with tissue-level (n=12) or bone-level (n=12) 10-mm long 4-mm wide zirconia implants. Primary and secondary stabilities will be measured with International Stability Quotient (ISQ) device. After 3 months, ceramic crowns will be supplied. Implant survival rates and parameters in relation to periimplant soft-tissues and bone health and anatomy will be recorded and evaluated after 1, 3 and 5 years.",[157],"Edentulous Alveolar Ridge",[159,160,161],"dental implants","zirconia","two-piece",{"date":163,"type":40},"2026-05-06",{"date":165,"type":40},"2022-07-03",{"date":167,"type":23},"2027-12-03",{"name":46,"class":47},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":17,"sex":18,"minAge":175,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":179,"conditions":180,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":182,"startDateStruct":183,"completionDateStruct":185,"leadSponsor":187,"locationsCount":48},"100329485","modeling-and-closed-loop-control-of-depth-of-anaesthesia-100329485","NCT03569839","Modeling and Closed-loop Control of Depth of Anaesthesia","Inclusion Criteria:\n\n* patients having vitroretinal surgery in general anaesthesia\n* patients having brain surgery in general anaesthesia\n* patients needing sedation in ICU\n* ASA 1-3\n\nExclusion Criteria:\n\n* ASA \\> 3\n* BMI \\> 35\n* drug addicts\n* patients taking psychotropic medicines\n* patients taking opioid analgesics (including tramadol)\n* severe psychiatric disease\n* central nervous system disease (except the reason for surgery)\n* arrhythmia affecting or preventing the measurements (e.g. chronic atrial fibrillation)\n* patients that received benzodiazepines","20 Years","70 Years",{"count":178,"type":23},50,"The study evaluates the effect of anaesthetic agents to depth of anaesthesia. An improved PK-PD model wil be developed that will provide the basis for understanding the mechanisms, simulating various scenarios and developing algorithms for better and safer administration of anaesthetic agents.",[181],"The Focus is to Develop a Closed-loop Control System for Anaesthesia in Vitroretinal Surgery, Surgery Due to Expansive Processes in Head, and Long-term Sedation",{"date":137,"type":40},{"date":184,"type":40},"2017-09-14",{"date":186,"type":23},"2028-12",{"name":46,"class":47},{"id":189,"slug":190,"hasResults":11,"nctId":191,"briefTitle":192,"officialTitle":193,"acronym":4,"eligibilityCriteria":194,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":195,"enrollmentInfo":196,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":197,"conditions":198,"keywords":200,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":48},"100612333","effects-of-ankle-evertor-fatigue-on-force-sense-and-neuromuscular-activation-in-subjects-with-chronic-ankle-instability-100612333","NCT07252219","Effects of Ankle Evertor Fatigue on Force Sense and Neuromuscular Activation in Subjects With Chronic Ankle Instability","Effects of Ankle Evertor Fatigue on Force Sense and Neuromuscular Activation During Submaximal Isometric Contractions in Individuals With and Without Chronic Ankle Instability","Inclusion criteria for the healthy control group (no CAI):\n\n* Age between 18 and 45 years,\n* No history of injuries or surgical procedures to the lower limbs,\n* No peripheral or central neurological impairments.\n\nInclusion criteria for the chronic ankle instability (CAI) group:\n\n* Age between 18 and 45 years,\n* No history of major surgical procedures on the lower limbs\n* No peripheral or central neurological impairments,\n* Diagnosed chronic ankle instability:\n\n  * First ankle sprain occurred at least one year prior to testing,\n  * At least three months since the most recent ankle sprain,\n  * Subjective feeling of ankle instability - CAIT (Cumberland Ankle Instability Tool) score \\\u003C 24.\n\nExclusion criteria for the CAI group:\n\n\\- Other pathologies of the ankle joint.","45 Years",{"count":178,"type":23},"The goal of this observational study is to investigate whether ankle evertor muscle fatigue impairs force perception and alters neuromuscular activation patterns during submaximal isometric contractions, and whether these effects differ between individuals with chronic ankle instability (CAI) and individuals without CAI.",[199],"Chronic Ankle Instability, CAI",[201,202,203,204],"chronic ankle instability","force sense","muscle fatigue","proprioception","2026-04-28",{"date":207,"type":40},"2026-04-29",{"date":209,"type":40},"2025-05-15",{"date":211,"type":23},"2026-05-04",{"name":46,"class":47},{"id":214,"slug":215,"hasResults":11,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":4,"eligibilityCriteria":219,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":195,"enrollmentInfo":220,"targetDuration":4,"studyType":94,"phases":4,"briefSummary":222,"conditions":223,"keywords":224,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":228,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":232,"locationsCount":48},"100613938","effects-of-ankle-evertor-fatigue-on-perturbed-gait-100613938","NCT07273097","Effects of Ankle Evertor Fatigue on Perturbed Gait","Effects of Ankle Evertor Fatigue on Gait Perturbation Responses in Individuals With and Without Chronic Ankle Instability","Inclusion criteria for the healthy control group (no CAI):\n\n* Age between 18 and 45 years,\n* No history of injuries or surgical procedures to the lower limbs,\n* No peripheral or central neurological impairments.\n\nInclusion criteria for the chronic ankle instability (CAI) group:\n\n* Age between 18 and 45 years,\n* No history of major surgical procedures on the lower limbs\n* No peripheral or central neurological impairments,\n* Diagnosed chronic ankle instability:\n\n  * First ankle sprain occurred at least one year prior to testing,\n  * At least three months since the most recent ankle sprain,\n  * Subjective feeling of ankle instability - CAIT (Cumberland Ankle Instability Tool) score \\\u003C 24.\n\nExclusion criteria for the CAI group:\n\n* Other pathologies of the ankle joint.\n* Acute pain",{"count":221,"type":23},40,"This study will investigate the effects of ankle evertor muscle fatigue on gait stability during treadmill walking with mechanical perturbations. Participants will walk at two speeds (0.4 m\u002Fs and 1.0 m\u002Fs) while random medial and lateral perturbations (\\\u003C10% body weight) are applied to the pelvis. Surface EMG from ankle muscles and center of pressure (COP)-based gait parameters (e.g., step length, step width, single support duration, COP trajectory) will be analyzed before and immediately after an isotonic fatigue protocol of the ankle evertors.",[199],[225,226,227],"perturbed walking","fatigue","treadmill",{"date":207,"type":40},{"date":230,"type":40},"2025-05-05",{"date":163,"type":23},{"name":46,"class":47},{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":239,"eligibilityCriteria":240,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":241,"enrollmentInfo":242,"targetDuration":4,"studyType":24,"phases":243,"briefSummary":244,"conditions":245,"keywords":248,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":258,"startDateStruct":260,"completionDateStruct":262,"leadSponsor":264,"locationsCount":48},"100625667","cervical-movement-control-before-and-after-anterior-cervical-discectomy-and-fusion-100625667","NCT07425613","Cervical Movement Control Before and After Anterior Cervical Discectomy and Fusion","Early Changes in Dynamic Cervical Movement Control Following Anterior Cervical Discectomy and Fusion: A Prospective Controlled Longitudinal Study","MOVE-ACDF","Inclusion Criteria\n\nSurgical group:\n\n* Age 18 to 65 years\n* Clinical diagnosis of cervical disc pathology at one segment level (e.g., cervical disc herniation or degenerative disc disease)\n* Scheduled to undergo anterior cervical discectomy and fusion (ACDF) as part of standard clinical care\n* Ability to understand study procedures and provide written informed consent\n\nNon-Surgical neck pain group:\n\n* Age 18 to 65 years\n* Clinical diagnosis of neck pain associated with cervical disc pathology\n* Not undergoing surgical treatment during the study period\n* Ability to understand study procedures and provide written informed consent\n\nExclusion Criteria:\n\n* Prior cervical spine surgery\n* Diagnosed neurological disorders unrelated to cervical disc pathology (e.g., multiple sclerosis, Parkinson's disease, stroke)\n* Known vestibular disorders affecting balance\n* Severe uncorrected visual impairment\n* Acute musculoskeletal injury of the neck or upper limb unrelated to the primary cervical condition\n* Inability to perform the head-tracking task\n* Cognitive impairment preventing informed consent","65 Years",{"count":22,"type":23},[26],"Degenerative cervical disc disease can cause neck pain, nerve symptoms, dizziness, and problems with balance and head movement control. The neck contains many sensory receptors that provide information about head position and movement to the brain. When cervical discs degenerate or compress nearby structures, this sensory communication may be disrupted. As a result, patients may experience reduced accuracy and coordination of head movements.\n\nAnterior cervical discectomy and fusion (ACDF) is a standard surgical procedure used to relieve nerve or spinal cord compression caused by cervical disc disease. The procedure is effective in reducing pain and neurological symptoms. However, it is not well understood whether ACDF also improves the way the neck and nervous system work together to control head movement.\n\nThe purpose of this study is to evaluate early changes in cervical movement control after ACDF. Patients scheduled for ACDF will be assessed before surgery and again one week after surgery. A group of healthy participants without neck pain will be assessed at the same time interval for comparison.\n\nCervical movement control will be measured using a computer-based head-tracking task. During this task, participants follow a moving target on a screen using controlled head movements. The system records measures of tracking accuracy and timing.\n\nThe primary research question is whether ACDF results in measurable short-term improvements in objective cervical movement control compared with healthy individuals over the same time period.\n\nIt is hypothesized that patients undergoing ACDF will demonstrate improvement in specific movement-control measures after surgery. However, broader patterns of movement-control impairment may not fully normalize in the early postoperative period.\n\nThe results of this study may improve understanding of how cervical spine surgery affects sensorimotor function and may help inform postoperative rehabilitation strategies.",[246,247],"Cervical Vertebral Disc Degeneration","Intervertebral Disc Displacement",[249,250,251,252,253,254,255,256],"Anterior Cervical Discectomy and Fusion","Cervical Sensorimotor Control","Cervicocephalic Kinaesthesia","Head and neck movement control test","Postoperative Recovery","Cervical Spine Surgery","Movement Control","Neck Proprioception","2026-02-13",{"date":259,"type":40},"2026-02-23",{"date":261,"type":23},"2026-02-20",{"date":263,"type":23},"2026-03-30",{"name":46,"class":47},{"id":266,"slug":267,"hasResults":11,"nctId":268,"briefTitle":269,"officialTitle":270,"acronym":4,"eligibilityCriteria":271,"healthyVolunteers":11,"sex":18,"minAge":57,"maxAge":241,"enrollmentInfo":272,"targetDuration":4,"studyType":24,"phases":274,"briefSummary":275,"conditions":276,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":257,"lastUpdatePostDateStruct":278,"startDateStruct":280,"completionDateStruct":282,"leadSponsor":284,"locationsCount":48},"100625130","kinematic-training-in-patients-with-neck-pain-based-on-machine-learning-classification-approach-100625130","NCT07418632","Kinematic Training in Patients With Neck Pain Based on Machine Learning Classification Approach","What is the Ability of Datamining Approaches to Cluster Patients With Idiopathic Neck Pain and Can Machine Learning Algorithms Provide More Efficient Rehabilitation and Less Recurrence Based on Kinaesthetic Training Protocols","Inclusion Criteria:\n\n* presence of neck pain\n* pain level minimum 3 of 10 on VAS\n* did not receive conventional physiotherapy in last 6 months\n\nExclusion Criteria:\n\n* any upper extremity pain within last 2 years\n* any neurological or vestibular dissorders\n* type 2 diabetes\n* diagnosed psychiatric dissorders\n* medication or alcohol consumptin in last 30 hours",{"count":273,"type":23},38,[26],"The goal of this clinical trial is to study if kinematic training based on novel kinematic assessment clasification approach can decrease chronic neck pain and prevent its reoccurance better than conventional kinematic training in adults. The main question\\[s\\] it aims to answer \\[is\u002Fare\\]:\n\nDoes clustering patients with neck pain based on head and neck movement characteristics lead to more efficient kinematic rehabilitation training and improved clinical outcomes\n\nResearchers will compare effects of cluster specific kinematic training to see if it effects pain levels and its reoccurance.\n\nParticipants will \\[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\\].",[277],"Chronic Neck Pain",{"date":279,"type":40},"2026-02-18",{"date":281,"type":23},"2026-03-18",{"date":283,"type":23},"2026-09-20",{"name":46,"class":47},{"id":286,"slug":287,"hasResults":11,"nctId":288,"briefTitle":289,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":17,"sex":18,"minAge":57,"maxAge":20,"enrollmentInfo":292,"targetDuration":4,"studyType":24,"phases":294,"briefSummary":295,"conditions":296,"keywords":298,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":300,"lastUpdatePostDateStruct":301,"startDateStruct":303,"completionDateStruct":305,"leadSponsor":307,"locationsCount":48},"100596672","difference-in-acute-responses-of-vascular-function-to-moderate-intensity-and-high-intensity-interval-training-in-healthy-and-prehypertensive-individuals-100596672","NCT07048509","Difference in Acute Responses of Vascular Function to Moderate-intensity and High-intensity Interval Training in Healthy and Prehypertensive Individuals","ACT-ON-ACUTE","Inclusion Criteria:\n\nNormotensive participants inclusion criteria:\n\n* 18 - 50 years of age, BMI \\\u003C 30, blood pressure (BP) within the optimal range according to the latest ESH guidelines (\\\u003C 120 mmHg systolic and\u002For \\\u003C 80 mmHg diastolic BP)\n* Sedentary or low active according to the Global Physical Activity Questionnaire (GPAQ) (Armstrong \\& Bull, 2006; Lim et al., 2012)\n* No prescribed medication and absence of chronic diseases\n\nInclusion criteria for prehypertensive individuals:\n\n* 18 - 50 years of age, BMI \\\u003C 30\n* Diagnosed prehypertension by a clinican from the Hypertension clinic, University clinical centre of Ljubljana using established criteria\n* Sedentary or low or moderately active according to the Global Physical Activity Questionnaire (GPAQ)\n* No prescribed medication and absence of chronic diseases\n\nExclusion Criteria:\n\n* Blood pressure out of the optimal range (normotensives)\n* High level of phyisical activity (moderate or high active according to GPAQ)\n* Hypotension\n* Chronic diseases\n* Prescribed medication\n* Lower extremity injury in the last six months\n* Menopause\n* Absence of normal menstrual cycle\n* Pregnancy\n* Smoking",{"count":293,"type":23},45,[26],"In this study, the investigators will evaluate acute changes in vascular function measures after moderate-intensity continuous and high-intensity interval exercise in healthy and prehypertensive individuals. Participants will be subjected to three separate visits: control condition (30 min rest), moderate-intensity continuous exercise, and high-intensity interval exercise. The investigators will measure aerobic capacity using a cardiopulmonary exercise test (CPET) using indirect gas-exchange to derive subsequent exercise intensity and maximal oxygen uptake. The investigators will evaluate different measures of vascular function (Pulse-wave velocity, Flow-mediated slowing, microvascular function) before and after each condition.\n\nThe study will involve two groups of participants: healthy individuals and prehypertensive individuals. The investigators aim to establish the reliability and validity of less-established methods of vascular function assessment (flow-mediated slowing and microvascular function) against established measures (pulse-wave velocity). The acute response of vascular function to different exercise intensities has not yet been thoroughly researched using the aforementioned measures in individuals with similar characteristics to the proposed study cohort.",[97,297],"Healthy",[299,103,106],"aerobic exercise","2025-12-15",{"date":302,"type":40},"2025-12-22",{"date":304,"type":40},"2025-06-24",{"date":306,"type":23},"2026-06",{"name":46,"class":47},{"id":309,"slug":310,"hasResults":11,"nctId":311,"briefTitle":312,"officialTitle":313,"acronym":4,"eligibilityCriteria":314,"healthyVolunteers":17,"sex":18,"minAge":151,"maxAge":176,"enrollmentInfo":315,"targetDuration":4,"studyType":24,"phases":316,"briefSummary":317,"conditions":318,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":48},"100508956","low-laser-therapy-and-hyaluronic-acid-as-an-adjunct-to-non-surgical-periodontal-therapy-100508956","NCT05907161","Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy","The Effect of Low Laser Therapy and Hyaluronic Acid as an Adjunct to Non-surgical Periodontal Therapy in Patients With Periodontitis","Inclusion Criteria:\n\n* systemically healthy\n* nonsmokers\n* untreated periodontal disease (stage 3, grade B or C)\n* plaque index will not exceed 20%\n* at least 20 teeth in oral cavity\n\nExclusion Criteria:\n\n* systemic diseases with impact on periodontal health\n* medication with impact on periodontal health\n* smokers\n* pregnant and lactating women\n* patients treated with antibiotics in the last 12 months\n* patients who had undergone periodontal treatment in the last year",{"count":293,"type":23},[26],"Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket.\n\nIn the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects.\n\nHyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.",[134],"2025-09-15",{"date":321,"type":40},"2025-09-19",{"date":323,"type":40},"2023-06-09",{"date":325,"type":23},"2026-02",{"name":46,"class":47},""]