[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Ljubljana, Faculty of Medicine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":86},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,47],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":15,"sex":16,"minAge":4,"maxAge":4,"enrollmentInfo":17,"targetDuration":4,"studyType":20,"phases":21,"briefSummary":23,"conditions":24,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100415769","effect-of-nano-structured-alumina-coating-on-the-bond-strength-of-zirconia-resin-bonded-fixed-dental-prostheses-100415769",false,"NCT04693949","Effect of Nano-structured Alumina Coating on the Bond Strength of Zirconia Resin-bonded Fixed Dental Prostheses","Inclusion Criteria:\n\n1\\. Patients with missing central or lateral incisor\n\nExclusion Criteria:\n\n1. inadequate edentulous space for the pontic\n2. signs of bruxism\n3. abutment tooth with active periodontal or periapical disease\n4. inadequate enamel bonding surface of the abutment tooth\n5. inadequate interocclusal space for a retainer wing and a proximal connector\n6. pontic guidance\n7. physical or psychological disease likely to interfere with normal conduct of the study",true,"ALL",{"count":18,"type":19},80,"ESTIMATED","INTERVENTIONAL",[22],"NA","The purpose of this study is to evaluate the clinical outcome of resin-bonded fixed dental prostheses (RBFDPs) pretreated with nanostructured alumina coating (NAC).\n\nThe study adopts a prospective, randomized, controlled, double-blind design contrasting the use of NAC to air-borne particle abrasion (APA) (control) as a surface pretreatment method of zirconia RBFDPs used for replacing missing central or lateral incisors. The primary outcome evaluated is the retention\u002Fsurvival of the zirconia RBFDPs pretreated with APA and NAC.",[25,26,27,28,29],"Missing Incisors","Zirconia Surface Pretreatment","Children","Adults","Debonding",[31,32,33],"Airborne particle abrasion","Nanostructured alumina coating","Resin-bonded fixed dental prostheses","RECRUITING","2026-06-18",{"date":37,"type":38},"2026-06-23","ACTUAL",{"date":40,"type":38},"2018-01-03",{"date":42,"type":19},"2030-01-01",{"name":44,"class":45},"University of Ljubljana, Faculty of Medicine","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":15,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":68,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":5},"100498100","self-harm-behaviour-among-the-most-at-risk-adolescents-100498100","NCT05765864","Self-harm Behaviour Among the Most At-risk Adolescents","Influences on and Prevention of Self-harm Behaviour Among the Most At-risk Adolescents","SH-MARA","CLINICAL GROUP:\n\nInclusion Criteria:\n\n* Suicidality\n* Self-harming with no intention to die\n\nExclusion Criteria:\n\n* Confirmed acute psychotic disorder\n* Intellectual disability\n* Severe physical illness (e.g. cardiovascular or renal disease)\n* Disease of the central nervous system (e.g. encephalitis, brain injury or haemorrhage, epilepsy)\n* Acute poisoning (including with psychoactive substances)\n\nCONTROL GROUP:\n\nInclusion Criteria:\n\n\\- Age 13-19\n\nExclusion criteria:\n\n* Suicidality\n* Self-harming with no intention to die\n* Known mental disorder (e.g. depression, bipolar disorder, schizophrenia, intellectual disability)\n* Severe physical illness (e.g. cardiovascular or renal disease)\n* Disease of the central nervous system (e.g. encephalitis, brain injury or haemorrhage, epilepsy)\n* Acute poisoning (including with psychoactive substances)\n* Mental disorder, history of suicidality or self-injurious behaviour in a first-degree relative (a parent or a sibling).","13 Years","18 Years",{"count":58,"type":19},400,"OBSERVATIONAL","In the proposed study, three objectives will be pursued:\n\n1. To develop a method to identify more effectively the acute and long-term risk of adolescents with the most threatening self-harm behaviours.\n2. To identify the factors that influence the risk of self-harm behaviours and the success of treatment\u002Ftreatment of these behaviours in the most at-risk adolescents (changes in these factors).\n3. Develop guidelines for more effective treatment of the most at-risk adolescents.\n\nFor this purpose, a sample of approximately 200 young people who will be hospitalised for suicide risk (the most at risk in Slovenia) and an approximately equal number of healthy adolescents will be included. At inclusion, the presence of several factors will be assessed by reviewing demographic data, clinical diagnosis, self-assessment questionnaires and clinical psychological tests (CSSRS, B-NSSI-AT, ISAS, LPFS-BF2.0, BPFSC-11, TSCC, PAI, ECR-RS, DASA-YV, ASHRS), social assessment, and blood sampling for genetic analyses (DNA isolation, sequencing, nucleotide sequence recognition, quantification and evaluation of short tandem repeats, identification of methylation sites). Longitudinal tracking of autoaggressive events and heteroaggressive events during hospitalisation will be performed and recorded on an ongoing basis. The risk and protective factors of the adolescents most at risk will be compared with a control group of adolescents. The same factors will be reassessed in the most at-risk adolescents after 6 and 18 months of treatment as usual. The data will be collected in a data entry and storage system that will ensure the privacy of the data entered in accordance with the GDPR.\n\nThis will allow the investigators to identify young people at particular risk of severe self-harm behaviour more reliably, to target them for more intensive and effective treatment, and thus to improve their safety, quality of life and prognosis in the short and long term.",[62,63,64,65,66,67],"Self-harm","Personality Disorder, Borderline","Epigenetic Disorder","Non-Suicidal Self Injury","Change; Mental","Difference, Individual",[69,70,71,72,73,74,75,76,77],"adolescent","deliberate self-harm","risk and protective factors","suicidal behavior","non-suicidal self-injury","risk assessment","attachment","genetics","epigenetics","2025-03-26",{"date":80,"type":38},"2025-03-28",{"date":82,"type":38},"2023-03-23",{"date":84,"type":19},"2025-10",{"name":44,"class":45},""]