[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Lorraine\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":140},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,55,86,112],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100625814","misapsy-childhood-maltreatment-food-insecurity-psychological-distress-and-professional-integration-among-socioeconomically-disadvantaged-young-adults-100625814",false,"NCT07427524","MISAPSY: Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults","Psychosocial Intervention With Precarious Young People: a Comparative Longitudinal Study on Psychological Distress and Food Insecurity","PRESPA","Inclusion Criteria:\n\n* Be aged 18 to 25 years\n* Be supported by a Mission Locale in Paris as part of a social and\u002For professional integration program\n* Voluntarily participate in the study after receiving clear information and signing an informed consent form\n* Experiencing severe food insecurity (positive response to item 8 of the FIES)\n* Experiencing significant psychological distress, defined by: PHQ-9 score \\> 15; GAD-7 score \\> 10\n* Have been exposed to at least one adverse childhood experience, identified via the CTQ-SF (Childhood Trauma Questionnaire - Short Form).\n\nExclusion Criteria:\n\n* Being unable to provide informed consent due to impaired comprehension or communication skills\n* Currently receiving psychiatric care for an acute or chronic mental illness requiring regular specialized treatment\n* Experiencing a social or medical emergency incompatible with the study (e.g., unstable emergency housing, acute suicidal crisis, ongoing hospitalization)\n* Being incarcerated, under guardianship or curatorship without specific legal authorization to participate in research\n* Having previously participated in a similar study or currently being engaged in a structured psychological intervention protocol\n* Having insufficient command of the French language, preventing comprehension of instructions, questionnaires, or interviews.","ALL","18 Years","25 Years",{"count":21,"type":22},70,"ESTIMATED","INTERVENTIONAL",[25],"NA","The MISAPSY study (Childhood Maltreatment, Food Insecurity, Psychological Distress and Professional Integration Among Socioeconomically Disadvantaged Young Adults) aims to model the complex interrelations between child maltreatment, trauma exposure, food insecurity, and psychological distress among precarious young adults enrolled in French youth employment and social integration services (Mission Locale).\n\nAdopting a methodology structured around three complementary components, this study consists of: (1) a cross-sectional survey to identify key associations ; (2) a qualitative study based on semi-structured interviews exploring psychologists' subjective experiences, and (3) a longitudinal comparative interventional study involving two different support programs to assess and compare the impact of these interventions on participants' food insecurity and psychological well-being.\n\nUsing a multi-phase design, MISAPSY seeks to move beyond linear risk-factor models by adopting a systemic and network-based approach to mental health and social vulnerability. The study integrates quantitative analyses, including network analyses, qualitative exploration of professional practices, and comparative longitudinal intervention to inform more holistic, equitable, and transferable models of care for vulnerable young adults.",[28,29,30,31,32,33],"Trauma and Stress-related Disorders","Food Insecurity","Child Maltreatment","Psychological Distress","Depression Symptoms","Anxiety Symptoms",[29,35,36,37,38,39,40,41],"Mental health","young adults","trauma","adverse childhood experience","psychological distress","precarity","mixed-methods","NOT_YET_RECRUITING","2026-04-28",{"date":45,"type":46},"2026-05-05","ACTUAL",{"date":48,"type":22},"2026-07-01",{"date":50,"type":22},"2027-06",{"name":52,"class":53},"University of Lorraine","OTHER",6,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":4,"eligibilityCriteria":61,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":62,"enrollmentInfo":63,"targetDuration":4,"studyType":23,"phases":65,"briefSummary":66,"conditions":67,"keywords":4,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},"100552149","theories-of-working-memory-and-consolidationreconsolidation-in-the-process-of-resorption-of-post-traumatic-symptoms-100552149","NCT06469333","Theories of Working Memory and Consolidation\u002FRECOnsolidation in the Process of Resorption of Post-traumatic Symptoms.","Theories of Working Memory and Consolidation\u002FRECOnsolidation in the Process of Resorption of Certain Post-traumatic Symptoms: Interventional, Randomized Single-center Study","Inclusion Criteria:\n\n* Present symptoms of acute stress (score between 22 and 35 on the Impact Event Scale-Revised, IES-R) and\u002For PTSD (higher score or equal to 36 on the IES-R), but at least present moderate to high psychological distress (score equal to or greater than 8 on the Kessler Abbreviated Psychological Distress Scale, K6);\n* Being in need of psychotherapeutic follow-up but not having started it yet;\n* Be aged between 18 and 65 years inclusive;\n* Speak and write French (be able to understand information and complete questionnaires independently);\n* Have good vision (being able to follow the movement of a white point on a screen);\n* Have good hearing and tactile abilities (being able to perceive auditory and tactile tones);\n* Have a computer equipped with a webcam;\n* Be informed and sign informed consent.\n\nExclusion Criteria:\n\n* Be an adult protected under guardianship or curatorship;\n* Be a person subject to a judicial safeguard measure;\n* Present a lack of autonomy implying an impossibility in terms of administering questionnaires and filling out questionnaires;\n* Have a vision defect implying an impossibility of visual tracking of a white dot;\n* Present a hearing defect and\u002For tactile abilities implying an impossibility of perception;\n* Have a neurological condition constituting measurement biases (muscular dysfunctions, perceptual dysfunctions, etc.);\n* Suffer from psychotraumatic and dissociative disorders of complex type (respectively evaluated with regard to the anamestistic data of the patients and with a score greater than 25 on the dissociative experiences scale (Dissociative Experiences Scale, DES);\n* Do not present psychological distress (score less than 8 on the Kessler Abbreviated Psychological Distress Scale, K6) ;\n* Have a drug or alcohol dependence;\n* Benefit from ongoing psychotherapeutic monitoring;\n* Have already benefited from psychotherapeutic follow-up or have participated in studies in the last 6 months, both involving EMDR therapy.","65 Years",{"count":64,"type":22},150,[25],"EMDR is a psychotherapeutic approach recommended by the World Health Organization (WHO) for the treatment of disorders such as post-traumatic stress disorder, anxiety, depression and, more generally, psychological distress. In all these disorders, intrusions are one of the symptoms leading to intense emotional distress. EMDR therapy, by making intrusions less emotional and less present in the mind (i.e. less vivid), would reduce psychological distress. This symptomatological reduction would be made possible by the therapist's application of alternating bilateral visual (rapid eye movements following a point from left to right), auditory (tones emitted alternately in the right ear and then in the left ear) and\u002For tactile (tapping with fingers on the left and right shoulders alternately) stimulations administered while the patient concentrates on his or her intrusive thoughts. Accordingly, the aim of this research is to investigate the efficacy of self-administration of Alternating Bilateral Stimulations (ABS), on the emotional intensity (emotionality) associated with negative intrusive thoughts (or intrusions).",[68,69,70,71,72,73,74,75],"Working Memory","Consolidation\u002FRecconsolidation Memory","Eye Movement Desensitization and Reprocessing","Alterning Bilateral Stimulation","Stress Disorders, Post-Traumatic","Intrusive Memories","Vividness","Emotivity","RECRUITING","2025-11-20",{"date":79,"type":46},"2025-11-26",{"date":81,"type":46},"2024-09-06",{"date":83,"type":22},"2026-06",{"name":52,"class":53},1,{"id":87,"slug":88,"hasResults":11,"nctId":89,"briefTitle":90,"officialTitle":91,"acronym":92,"eligibilityCriteria":93,"healthyVolunteers":94,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":95,"targetDuration":4,"studyType":23,"phases":97,"briefSummary":98,"conditions":99,"keywords":101,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":4},"100611884","evaluation-of-a-customizable-antibiotic-stewardship-program-tailored-to-french-nursing-homes-100611884","NCT07246382","Evaluation of a Customizable Antibiotic Stewardship Program Tailored to French Nursing Homes","Evaluation of A Customizable Antibiotic Stewardship Program Based on a Comprehensive Assessment of Organizations and Health Professionals' Attitudes, and Tailored to French Nursing Homes' Needs","ORANEAT","Nursing homes\n\nInclusion criteria:\n\n• Nursing home located in one of the geographical areas participating in the study in two French regions (i.e., geographical areas covered by experts in antibiotic stewardship and\u002For in infection prevention and control who agreed to participate in the study)\n\nExclusion criteria:\n\n* Nursing home with a pharmacy for internal use\n* Participation to the pilot study\n* Data from the Health Insurance reimbursement database (Système national des données de santé) not available on the study period\n* Refusal of the nursing director to participate in the study (for Arm 1 only)\n\nResidents (Outcomes 1 to 4 and outcome 12)\n\nInclusion criteria:\n\n• Resident aged 18 or more who had lived in one of the participating nursing homes during the study period.\n\nExclusion criteria:\n\n\u002F\n\nHealthcare professionals (Outcomes 11, 13 and 15)\n\nInclusion criteria:\n\n• Healthcare professionals aged 18 or more working in one of the participating nursing homes from Arm 1 (including healthcare professionals who provide services to or collaborate with the nursing home even if they are not on-site, e.g., private general practitioners, community pharmacists, microbiologists, and professionals responsible for the implementation support).\n\nExclusion criteria:\n\n• Refusal to complete the self-administered questionnaires or to participate in qualitative investigations.",true,{"count":96,"type":22},66,[25],"To tackle antimicrobial resistance (AMR), i.e., one of the top 10 global health threats, antimicrobial stewardship (AMS) programs, i.e., coherent sets of actions promoting responsible use of antimicrobials, have been developed. Despite growing evidence about their effectiveness, their implementation remains suboptimal. Qualifying as complex interventions, these programs are prone to interactions with context, potentially compromising their successful transfer to other settings. AMR remains critical in French nursing homes (NHs). AMS programs have proven effective in reducing antimicrobial resistance in hospitals and in NHs. However, the evidence is inconsistent across studies in NHs and mostly based on North American and North European AMS programs and studies, raising concerns about transferability that might occur while implementing such AMS programs in French NHs. For instance, health systems and NH funding and organization vary considerably across countries, resulting in potential key determinants driving antibiotic use in such facilities in some countries that might remain untargeted by AMS programs developed in other countries. In addition, inconsistent effectiveness of AMS programs in NHs might also result from implementation issues, raising concerns about the strategies used to implement such programs. Based on extensive logic models linking psychosocial and organizational determinants driving antibiotic use in NHs of diverse countries, we developed and pilot-tested a customizable AMS program (i.e., the ORANEAT program) suited to French NHs, including three major components: (i) a contextual diagnostic regarding AMS in the targeted NH; (ii) based on the results of the contextual diagnostic, a bundle of tools selected from an AMS-toolkit including actions and tools suited to French NH setting; and (iii) implementation support relying on French structures involved in tackling AMR (i.e., CRAtb and CPias).\n\nThis study aims to assess the effectiveness, the sustainability, the implementation, and the transferability of the ORANEAT program in French NHs, using a mixed-method approach (quantitative and qualitative data). A cluster randomized controlled trial with two arms (ORANEAT program vs. no specific intervention) will be conducted; the cluster being the NH. The primary outcome to measure the effectiveness is total antibiotic use expressed in defined daily doses\u002F1000 resident-days\u002Fmonth.",[100],"Antibacterial Agents",[102,103],"Antimicrobial Stewardship","Nursing Homes","2025-11-17",{"date":106,"type":46},"2025-11-24",{"date":108,"type":22},"2025-12-15",{"date":110,"type":22},"2028-01-30",{"name":52,"class":53},{"id":113,"slug":114,"hasResults":11,"nctId":115,"briefTitle":116,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":94,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":120,"targetDuration":4,"studyType":122,"phases":4,"briefSummary":123,"conditions":124,"keywords":127,"overallStatus":76,"whyStopped":4,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":139},"100587002","protocol-study-on-addiction-trauma-and-immigration-among-vulnerable-young-adults-in-grand-est-100587002","NCT06922721","Protocol Study on Addiction, Trauma and Immigration Among Vulnerable Young Adults in Grand Est","ATICC: A Mixed-Methods Study on Addiction, Trauma, and Immigration Among Vulnerable Young Adults in the Grand Est Youth Network","ATICC","Inclusion Criteria:\n\n* Resident in a Housing center, speak and read french, adult participants who are not under guardianship or curatorship, any cultural background.\n\nExclusion Criteria:\n\n* minors, don't speak and read french, adults under guardianship and curatorship.",{"count":121,"type":22},182,"OBSERVATIONAL","The ATICC study (Addiction, Trauma, and Immigration, Prevention and Cross-Cultural Support for Care) investigates the complex relationships between trauma, substance use, migration experiences, and mental health perceptions among vulnerable young adults in Transitional Housing (Foyers de Jeunes Travailleurs) in France. Using a tripartite methodology, the study includes: (1) a cross-sectional survey to identify risk factors, (2) qualitative interviews to explore individual experiences, and (3) a longitudinal intervention using focus groups to assess psychological well-being and attitudes toward care. The findings will contribute to developing culturally adapted prevention and support programs.",[28,125,126],"Substance Use Disorder (SUD)","Substance Use Risk",[128,37,129,35,36,130],"addiction","Immigration","Substance use","2025-04-03",{"date":133,"type":46},"2025-04-10",{"date":135,"type":46},"2025-01-06",{"date":137,"type":22},"2025-12",{"name":52,"class":53},7,""]