[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Luxembourg\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":83},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,50],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":5},"100617404","building-ukraines-strength-in-ptsd-treatment-and-research-100617404",false,"NCT07318181","Building Ukraine's Strength in PTSD Treatment and Research","Fostering Ukraine's Capacity in the Delivery and Research of Innovative Evidence-based PTSD Treatment","Lux4UA","Inclusion Criteria:\n\n1. being adults 18-65 years,\n2. having a diagnosis of PTSD determined by DSM-5-TR or ICD-11 and\u002For\n3. having PTSD symptoms causing clinically significant distress or impact on social, occupational, or other areas of functioning, as defined by the PTSD Checklist PCL-5,\n4. being a resident of Ukraine.\n\nExclusion Criteria:\n\n1. having any other acute comorbid mental health conditions,\n2. receiving any other parallel PTSD treatment,\n3. being unable to provide informed consent, having severe cognitive impairment, or being otherwise unlikely to adhere to study procedures.","ALL","18 Years","65 Years",{"count":21,"type":22},120,"ESTIMATED","INTERVENTIONAL",[25],"NA","The Lux4UA project aims to support mental health treatment in Ukraine, especially for those who have experienced traumatic events due to the ongoing conflict and forced displacement. As rates of Post-Traumatic Stress Disorder (PTSD) rise among civilians, military personnel, and refugees, the need for effective trauma care becomes urgent. PTSD is a mental health condition that can develop after experiencing trauma, leading to flashbacks, nightmares, anxiety, and other symptoms that significantly impact daily life.\n\nThis project introduces an innovative method called the Reconsolidation of Traumatic Memories (RTM) Protocol, which helps individuals reduce distressing memories and trauma-related symptoms. Unlike traditional therapies, the RTM Protocol aims to quickly alleviate PTSD symptoms without requiring patients to relive or discuss in detail their traumatic experiences, which can sometimes be overwhelming. Instead, it employs carefully guided imaginary exercises to help patients reprocess and feel less emotional distress when recalling traumatic memories. This structured approach can lead to significant improvements in just three to five sessions.\n\nThe Lux4UA project brings together mental health professionals and researchers from Ukraine, Luxembourg, and the United States to test how well this treatment works in Ukraine and to understand if it can be easily integrated into the country's mental health system. By studying the RTM Protocol in three main settings-hospital care and outpatient (walk-in) clinics for veterans and therapy practices for civilians-the project will assess the treatment's effectiveness for people with different needs and backgrounds. It will also evaluate how comfortable and satisfied both mental health practitioners and patients are with the treatment.\n\nA key part of the project is training Ukrainian mental health professionals in the RTM Protocol. This training ensures that local mental health professionals are well-prepared to deliver the treatment and support trauma survivors long after the project ends, building a sustainable mental health system in Ukraine. The project will involve careful monitoring of how patients respond to the treatment, paying special attention to their well-being throughout each session.\n\nTo evaluate the treatment's success, the project will measure changes in PTSD symptoms, as well as signs of anxiety and depression that often accompany trauma. The project will also assess the RTM Protocol's adaptability to Ukrainian needs, seeing if any modifications are necessary to better suit the local context.",[28,29,30],"Post Traumatic Stress Disorder","Post Traumatic Stress Disorder PTSD","Post-Traumatic Stress Disorder, PTSD",[28,32,33,34,35,36,37],"RTM","RTM Protocol","PTSD","trauma therapy","traumatic memories","memory reconsolidation","RECRUITING","2026-01-14",{"date":41,"type":42},"2026-01-15","ACTUAL",{"date":44,"type":42},"2026-01-01",{"date":46,"type":22},"2028-05",{"name":48,"class":49},"University of Luxembourg","OTHER",{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":58,"enrollmentInfo":59,"targetDuration":4,"studyType":23,"phases":61,"briefSummary":62,"conditions":63,"keywords":66,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":74,"lastUpdatePostDateStruct":75,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":82},"100556257","periodic-fasting-for-treatment-of-long-covid-in-adults-a-pilot-study-100556257","NCT06522750","Periodic Fasting for Treatment of Long Covid in Adults: a Pilot Study","Pilot Study on the Feasibility of an RCT: Evaluating Periodic Fasting as a Treatment Strategy for Long Covid in Adults","FASTCOV-P","Inclusion Criteria:\n\n* Age 18-64\n* Diagnosis Long Covid Syndrome (post-acute COVID-19 symptoms persisting ≥12 weeks)\n* Normal body Mass Index (18.5 to 25 kg\u002Fm2)\n* Marginal Iron status ( PF\\\u003C 25 ng\u002Fml)\n* Able to communicate in and comprehend English and\u002For German and\u002For French language\n* Present written \u002F signed declaration of consent\n* Ability to understand the patient information and willingness to sign the consent form\n* Consent to specimen collection and specimen use\n\nExclusion Criteria:\n\n* Current underweight condition (body mass index less than 18.5 kg\u002Fm2) or weight loss exceeding 3 kg within the last month or 5 kg within the last three months.\n* Existing \u002F current eating disorder within the past five years (e.g., anorexia, bulimia).\n* Psychiatric condition that limits understanding of the examination protocol (unable to consent)\n* Severe internal disease (e.g. kidney deficiency with creatinine \\> 2mg\u002Fdl), chronic inflammatory illness other than LCS\n* Participation in another intervention study.\n* Existing vegan diet or fasting during the last six months\n* Pregnancy or breastfeeding status.\n* Presence or suspicion of pre-existing ME\u002FCFS or early autonomous dysfunction\n* Diagnosis of chronic inflammatory bowel diseases, celiac disease or colorectal cancer according to the guidelines of the German Society of Gastroenterology\n* Use of anti-psychotic drugs\n* Antibiotic use during the previous 12 months\n* Start of novel drug therapy\n* Contraindication for additional blood draws (e.g. hemoglobin \\\u003C10)","64 Years",{"count":60,"type":22},20,[25],"Background:\n\nLong COVID, characterized by persistent symptoms following acute COVID-19 infection, has emerged as a significant public health concern. Symptoms range from fatigue, cognitive impairments, to respiratory difficulties, affecting patients\\' quality of life. Dietary interventions, particularly fasting, have historically been used to modulate immune responses and improve health outcomes in various conditions. The Buchinger-Wilhelmi method represents a structured and medically supervised fasting approach. Given the inflammatory nature of long COVID, fasting may offer therapeutic benefits by modulating the immune response, enhancing cellular repair mechanisms, and resetting metabolic processes.\n\nObjectives:\n\nThis clinical trial aims to assess the feasibility of a 7-day ambulatory fasting intervention using the Buchinger-Wilhelmi method on long COVID patients as primary objective. As secondary objectives, the study will investigate the potential beneficial impact of fasting on clinical, biological, and psychological parameters over a period of 4 weeks, offering insights into potential therapeutic avenues for long COVID management.\n\nStudy timeline:\n\nThe research will span a period of 4 weeks\n\nStudy population:\n\nThis study aims to recruit around 20 participants, who will all receive a fasting intervention using the Buchinger-Wilhelmi method.\n\nBiological sample and data collection:\n\nParticipants will undergo various data and sample collection procedures, including blood draws of up to 90 42 ml per visit, collection of peripheral mononuclear cells, stool samples, and completion of questionnaires in a smartphone-based Application (MyCap).\n\nSample analysis:\n\nThe collected samples will be subjected to a range of analyses, including the assessment of serological markers for routine blood chemistry, evaluation of inflammation markers, and examination of stool samples.",[64,65],"Long Covid","Chronic Inflammation",[67,68,69,70,71,72,73],"long covid","fasting","caloric restriction","chronic inflammation","dysbiosis","mitochondrial dysfunction","thrombosis","2025-03-25",{"date":76,"type":42},"2025-03-30",{"date":78,"type":42},"2025-02-19",{"date":80,"type":22},"2025-09-30",{"name":48,"class":49},1,""]