[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Massachusetts, Boston\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":153},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,46,72,104,126],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":34,"lastUpdatePostDateStruct":35,"startDateStruct":38,"completionDateStruct":40,"leadSponsor":42,"locationsCount":45},"100361091","neural-control-of-kidney-blood-flow-during-exercise-in-african-american-adults-100361091",false,"NCT03981640","Neural Control of Kidney Blood Flow During Exercise in African American Adults","Neurovascular Control of Renal Blood Flow During Exercise in African American Adults","Inclusion Criteria:\n\n* Self-report as either African American or White racial identity\n* Born in United States\n* Both biological parents identify as same racial identity as participant\n* Recreationally active (participating in physical activity for at least 20 minutes per day, at least three times per week, but not training for competitive events)\n* Fluent in English\n\nExclusion Criteria:\n\n* Hispanic or Latino\n* Females who are pregnant or lactating\n* Cardiovascular or renal disease\n* Hypertension (blood pressure of more than or equal to 130\u002F80 mmHg)\n* Diabetes\n* Obesity (body mass index of more than or equal to 30 kg\u002Fm2)\n* Smoker\u002FTobacco user\n* Acute medical conditions\n* Taking prescribed cardiovascular, antihypertensive, or renal medications",true,"ALL","18 Years","35 Years",{"count":21,"type":22},32,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this clinical trials is to learn if healthy young African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are:\n\n* Do healthy young AA adults have a larger decrease in kidney blood flow during exercise compared to W adults?\n* Do healthy young AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults?\n\nDuring two visits in the research lab, participants will:\n\n* Perform a fitness test\n* Perform cycling exercise while lying down\n* Undergo a cold hand test\n* Perform a mental math test\n\nCompleting this clinical trial will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.",[28],"Healthy",[30,31,32],"Exercise","Cold stress","Mental stress","RECRUITING","2026-06-23",{"date":36,"type":37},"2026-06-26","ACTUAL",{"date":39,"type":37},"2024-09-30",{"date":41,"type":22},"2026-08",{"name":43,"class":44},"University of Massachusetts, Boston","OTHER",1,{"id":47,"slug":48,"hasResults":11,"nctId":49,"briefTitle":50,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":11,"sex":17,"minAge":52,"maxAge":4,"enrollmentInfo":53,"targetDuration":4,"studyType":23,"phases":55,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":4},"100339906","tai-chi-intervention-for-geriatric-pain-syndrome-100339906","NCT03705598","Tai Chi Intervention for Geriatric Pain Syndrome","Inclusion Criteria:\n\n1. be 65 years or older\n2. report chronic multisite (≥2 sites) musculoskeletal pain\n3. have had 1 or more falls in the past year or current use of an assistive device (a cane or walker)\n4. be able to walk 20 feet without help\n5. be able to communicate in English\n\nExclusion Criteria:\n\n1. actively engage in moderate to vigorous exercise for more than 40 min\u002Fweek\n2. practiced Tai Chi or other mind-body exercise within the past year, or practiced Tai Chi or other mind-body exercise regularly for at least 3 months within the past 5 years\n3. have cognitive impairment consistent with dementia (Montreal Cognitive Assessment (MOCA) score \\\u003C 18 after corrections),\n4. have a diagnosis of a disease\u002Fcondition that would interfere with their study participation (e.g., rheumatoid arthritis, stroke, Parkinson's disease, degenerative neuromuscular disease, unstable cardiac disease, Alzheimer's disease or other dementia, terminal disease)","65 Years",{"count":54,"type":22},266,[25],"Accumulating evidence supports that more pain, whether measured by number of pain sites or pain severity, is associated with poorer cognitive function and mobility, and fall risk in older persons. Tai Chi which holistically integrates physical and cognitive functions offers the possibility not only of alleviating pain but also improving attention and mobility in the many older adults who have chronic multisite pain. This proposed full-size randomized controlled Tai Chi trial is a direct extension of the investigators' previous work examining chronic pain, attention demands, mobility and falls in the older population, and is built on the investigators' National Institute on Aging-supported Tai Chi feasibility and acceptability pilot studies among older adults with multisite pain and risk for falls. The goal of this single-blinded randomized controlled trial is to examine the effects of a 24-week Tai Chi intervention on chronic pain, cognition, mobility, fear of falling, and fall rate in older adults with multisite pain and at risk for falls. The results of this study will provide a foundation to establish the clinical significance of Tai Chi in the management of chronic multisite pain and to explore the mechanisms through which Tai Chi improves chronic pain symptoms and lowers fall rate in at-risk older adults.",[58,59],"Chronic Pain","Falls",[61,58,59,62],"Tai Chi","Older Adults","NOT_YET_RECRUITING","2026-06-11",{"date":66,"type":37},"2026-06-15",{"date":68,"type":22},"2026-08-01",{"date":70,"type":22},"2030-07-31",{"name":43,"class":44},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":52,"enrollmentInfo":79,"targetDuration":4,"studyType":23,"phases":81,"briefSummary":83,"conditions":84,"keywords":90,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":95,"lastUpdatePostDateStruct":96,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},"100583416","phase-2-low-cost-screening-and-image-guided-photodynamic-therapy-pdt-of-premalignant-and-malignant-oral-lesions-100583416","NCT06876038","Low-cost Screening and Image-guided Photodynamic Therapy (PDT) of Premalignant and Malignant Oral Lesions","A Comprehensive Platform for Low-cost Screening and Image-guided Photodynamic Therapy (PDT) Treatment of Pre-malignant and Malignant Oral Lesions in Low-resource Setting","Subject Inclusion Criteria\n\n1. One grossly visible OPML, with histopathologically confirmed diagnosis of moderate, severe, and carcinoma in situ measuring ≥ 10 mm in diameter.\n2. Willing and available for follow-up for at least one year and at prerequisite time intervals.\n3. All patients above the age of 18 years and willing to voluntarily give a signed informed consent.\n4. Karnofsky Performance Score above 80 or ECOG 0 or 1.\n5. The subjects meeting the following laboratory eligibility criteria during a time not older than 2 months before accrual\n\n   * Hemoglobin level above or equal to 10%\n   * WBC \\>3000\u002Fmm3\n   * Platelets count \\>100000\u002Fmm3\n   * Total bilirubin, AST (SGOT), ALT (SGPT) \\\u003C 1.5 times the Upper Limit Normal\n   * eGFR \\> 60 ml\u002Fmin\n   * Serum Creatine less than 2 times the Upper Limit of laboratory normal\n   * INR\u002F PT and PTT within laboratory normal limits\n\nExclusion criteria:\n\n1. Hypersensitivity against active substances and porphyrins.\n2. Known diagnosis of porphyria.\n3. Simultaneous use of other potentially phototoxic substances (eg; tetracyclines, sulphonamides, fluoroquinolones, hypericin extracts).\n4. Uncontrolled concurrent illness, including but not limited to ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, uncontrolled cardiac and renal diseases or psychiatric illness.\n5. Subjects with inherited or acquired bleeding and clotting disorders\n6. Women who are breastfeeding\u002F have a positive urine pregnancy test or are planning their family.\n7. Patients who have taken supplements of retinol, beta carotene, vitamin E, Selenium, or other chemo-preventive therapy at least one month prior to the baseline visit.\n8. Patients with histological evidence of no dysplasia, mild dysplasia, invasive carcinoma, and any active malignant disease.\n9. Patients with behavioral and cognitive impairment.\n10. Patients who are concurrently diagnosed and undergoing treatment for other head and neck cancers.\n11. Patients with large lesions, which, in the investigator's opinion, may require reconstructive surgery after excision.\n12. The subjects, in the opinion of the Institutional Principal Investigator, are not an appropriate candidate for study participation due to alcoholism and abstinence.\n13. Patient who was in a clinical trial for 4 weeks before participation in the present trial.",{"count":80,"type":22},65,[82],"PHASE2","The primary goal of this study is to see if photodynamic therapy (PDT) is effective for treatment of lesions in the oral cavity which have high risk of becoming oral cancer. PDT treatment uses a drug, called a photosensitizer, which makes the diseased cells become light-sensitive such that they are destroyed when laser light is delivered to the target lesion. In this study a new handheld device, called SITOS (a \"Screen, Image and Treat Optical System), is used. The ability of this device to simultaneously visualize the inside of the mouth and deliver laser light to the target site will be evaluated. The main questions this study seeks to answer are:\n\n* Can this treatment completely cure oral potentially malignant lesions (OPML) without need for surgery?\n* Do lesions recur after PDT treatment?\n* Is the SITOS device easy to use for the doctor and comfortable for the patient, both as an oral imaging device and as a treatment device?",[85,86,87,88,89],"Oral Cancer","Oral Cavity Cancer","Oral Leukoplakia","Oral Lichen Planus","Oral Squamous Cell Carcinoma",[91,92,93,94],"High grade dysplasia (HGD)","Severe\u002FModerate dysplasia","Carcinoma-in-situ (CIS)","Oral potentially malignant lesion (OPML)","2026-03-16",{"date":97,"type":37},"2026-03-19",{"date":99,"type":22},"2026-09",{"date":101,"type":22},"2028-12",{"name":43,"class":44},2,{"id":105,"slug":106,"hasResults":11,"nctId":107,"briefTitle":108,"officialTitle":109,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":110,"maxAge":111,"enrollmentInfo":112,"targetDuration":4,"studyType":23,"phases":114,"briefSummary":115,"conditions":116,"keywords":117,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":45},"100595185","kidney-blood-flow-during-exercise-in-older-african-american-adults-100595185","NCT07029165","Kidney Blood Flow During Exercise in Older African American Adults","Neurovascular Control of Renal Blood Flow During Exercise in Older African American Adults","55 Years","79 Years",{"count":113,"type":22},12,[25],"The goal of this preliminary study is to learn if healthy older African American (AA) adults have a larger change in their kidney blood flow during exercise compared to White (W) adults. The main questions that this study aims to answer are:\n\n* Do healthy older AA adults have a larger decrease in kidney blood flow during exercise compared to W adults?\n* Do healthy older AA adults have a larger decrease in kidney blood flow during other types of stress compared to W adults?\n\nDuring one visit in the research lab, participants will:\n\n* Perform cycling exercise while lying down\n* Undergo a cold hand test\n* Perform a mental math test\n\nCompleting this preliminary study will help researchers to understand more about why many AA adults have heart and kidney problems, so future research can study ways to reduce the number of AA adults who have these health issues.",[28],[30,31,32],"2025-12-22",{"date":120,"type":37},"2025-12-23",{"date":122,"type":37},"2024-12-04",{"date":124,"type":22},"2026-06",{"name":43,"class":44},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":133,"targetDuration":4,"studyType":23,"phases":135,"briefSummary":136,"conditions":137,"keywords":140,"overallStatus":33,"whyStopped":4,"lastUpdateSubmitDate":145,"lastUpdatePostDateStruct":146,"startDateStruct":148,"completionDateStruct":150,"leadSponsor":152,"locationsCount":45},"100558685","vascular-mechanisms-functional-outcomes--exercise-among-persons-with-multiple-sclerosis-with-hypertension-100558685","NCT06554340","Vascular Mechanisms, Functional Outcomes, & Exercise Among Persons With Multiple Sclerosis With Hypertension","Targeting Vascular Mechanisms of Functional Outcomes Via Home-based Exercise Training Among Persons With Multiple Sclerosis Who Have Hypertension","Inclusion Criteria:\n\n* Persons with confirmed multiple sclerosis diagnosis with Expanded Disability Status Scale scores of 4-6.5, characteristic of 2nd stage of multiple sclerosis;\n* Hypertension defined as elevated, or Stage 1 or 2, as per the 2017 American Heart Association guidelines (brachial systolic blood pressure \\> 120 mmHg or brachial diastolic blood pressure \\> 80 mmHg)\n* Persons who are physically inactive (less than 60 min\u002Fwk of physical activity);\n* Persons with body mass index \\\u003C 40 kg\u002Fm2;\n* Persons who are not confined to a wheel chair;\n* Multiple sclerosis relapse in the past 30 days;\n* People with stable pharmacotherapy.\n\nExclusion Criteria:\n\n* People with additional cardiovascular comorbidities;\n* People with type 1 diabetes mellitus;\n* Physician disapproval to participating in the study;\n* Space constraints to fit a cycle ergometer at the home of prospective participants.",{"count":134,"type":22},80,[25],"The goal of this study is to determine if 12 weeks of cycling exercise training at home will improve three parameters: 1) blood pressure, 2) cognition, and 3) walking ability among persons with multiple sclerosis who have high blood pressure, when compared to a group that engages in a 12-week home-based stretching program.\n\nThe main questions this study aims to answer are:\n\n1. Can home-based cycling exercise training improve blood pressure by increasing blood vessel dilation in people with multiple sclerosis?\n2. Can cycling exercise training improve cognition and walking mobility in people with multiple sclerosis by improving blood pressure?\n\nThe investigators will compare home-based cycling training to stretching to see if cycling training improves cognition, walking mobility, blood pressure, and fitness in people with multiple sclerosis.\n\nParticipation in this study will take 13-14 weeks, with participants being randomized (like flipping a coin, a 50-50 chance of being in either group) to the home-based cycling training or the stretching group.\n\nAll participants will be asked to\n\n* Visit the laboratory two times, one before the beginning of the intervention (home-base training and stretching group) and one at the end of the intervention.\n* During visits, participants will complete tests related to cognition, walking mobility, blood pressure and fitness.",[138,139],"Multiple Sclerosis","Hypertension",[141,142,143,144],"exercise","blood pressure","mobility","cognition","2025-08-15",{"date":147,"type":37},"2025-08-22",{"date":149,"type":37},"2025-04-15",{"date":151,"type":22},"2027-08",{"name":43,"class":44},""]