[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Medicine and Pharmacy at Ho Chi Minh City\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":662},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,34,0,25,[9,51,77,99,127,157,177,196,229,254,278,301,328,351,373,405,427,456,487,516,538,565,592,614,636],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":21,"enrollmentInfo":22,"targetDuration":4,"studyType":25,"phases":26,"briefSummary":28,"conditions":29,"keywords":32,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":50},"100631132","effects-of-electroacupuncture-at-np82-and-sp15-on-bowel-motility-in-healthy-subjects-100631132",false,"NCT07496697","Effects of Electroacupuncture at NP82 and SP15 on Bowel Motility in Healthy Subjects","Investigation of Bowel Motility Changes Following Electroacupuncture at NP82 (Tongbian) and SP15 (Daheng) Acupoint Pair in Healthy Volunteers","EABM-HV","Inclusion Criteria:\n\n* Healthy volunteers aged 18 years and older.\n* No symptoms related to constipation after comprehensive evaluation based on Rome IV criteria.\n* No gastrointestinal symptoms (abdominal pain, diarrhea, blood in stool, constipation, or bloating) in the 4 weeks prior to study participation.\n* No use of medications that promote or inhibit bowel motility in the 4 weeks prior to participation (including prokinetics, laxatives, antispasmodics, or opioids).\n* Fasting for at least 4 hours before the study session.\n* No mental or intellectual disorders; capable of understanding the acupuncture and assessment procedures.\n* Willingness to participate and signed informed consent form.\n\nExclusion Criteria:\n\n* Participants with severe medical conditions (heart, brain, liver, kidney, hematological system, infectious diseases, cancer, or psychiatric disorders).\n* Metabolic or functional disorders such as irritable bowel syndrome (IBS), thyroid dysfunction, or glucose\u002Flipid metabolism disorders.\n* Use of bowel motility-altering medications within the 4 weeks prior to participation.\n* Participation in other clinical trials within the last 2 months.\n* Received acupuncture treatment within the last month.\n* Skin ulcers, abscesses, or infections at the acupuncture sites.\n* Known metal allergy or severe needle phobia.",true,"ALL","18 Years","30 Years",{"count":23,"type":24},30,"ESTIMATED","INTERVENTIONAL",[27],"NA","This study aims to investigate how a specific combination of electroacupuncture points, Tongbian (NP82) and Daheng (SP15), affects bowel movements in healthy volunteers. Constipation is a significant health issue, especially for post-stroke patients, and current treatments like laxatives often have unwanted side effects. The researchers want to determine if stimulating these two acupuncture points can objectively increase the frequency of bowel activity.\n\nParticipants will undergo a three-stage procedure: a 30-minute period of baseline bowel sound recording, followed by 20 minutes of electroacupuncture stimulation at the specific points, and a final 30-minute recording period after the intervention. Throughout the study, an advanced digital stethoscope (3M™ Littmann® CORE) will be used to record bowel sounds objectively. This data will then be analyzed to measure any significant changes in bowel motility caused by the acupuncture.",[30,31],"Gastrointestinal Motility","Healthy",[33,34,35,36,37],"Electroacupuncture","Bowel Sounds","Tongbian (NP82)","Daheng (SP15)","Digital Stethoscope","RECRUITING","2026-06-22",{"date":41,"type":42},"2026-06-24","ACTUAL",{"date":44,"type":42},"2026-04-30",{"date":46,"type":24},"2026-07-30",{"name":48,"class":49},"University of Medicine and Pharmacy at Ho Chi Minh City","OTHER",1,{"id":52,"slug":53,"hasResults":12,"nctId":54,"briefTitle":55,"officialTitle":56,"acronym":4,"eligibilityCriteria":57,"healthyVolunteers":12,"sex":19,"minAge":58,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":25,"phases":61,"briefSummary":62,"conditions":63,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":4},"100642572","efficacy-of-the-three-needle-dazhui-technique-combined-with-electroacupuncture-for-cervical-spondylosis-with-wind-cold-syndrome-100642572","NCT07640126","Efficacy of the \"Three-Needle Dazhui\" Technique Combined With Electroacupuncture for Cervical Spondylosis With Wind-Cold Syndrome","Evaluation of the Efficacy of the \"Three-Needle Dazhui\" Technique Combined With Electroacupuncture in Managing Pain and Improving Neck Disability in 74 Patients With Cervical Spondylotic Radiculopathy and Wind-Cold Syndrome: A Randomized, Single-Blind, Controlled Trial","Inclusion Criteria:\n\n* Consent: Participants must voluntarily agree to participate and sign a written informed consent form.\n* Age: Individuals aged 18 years or older.\n* Pain Intensity: Patients with a baseline pain score of VAS ≥ 50 mm on the Visual Analog Scale.\n* Modern Medicine Diagnosis (Cervical Spondylotic Radiculopathy - CSR) Patients must meet the diagnostic criteria for CSR due to cervical spondylosis according to Decision 361\u002FQD-BYT, including:\n\n  * Cervical Spine Syndrome: Localized neck pain, restricted range of motion, and tenderness upon palpation of the spinous processes or paravertebral areas.\n\nRadicular Syndrome: Neck pain radiating to the occipital region, shoulder, arm, or hand.\n\n* Physical Examination: At least one positive result from the following tests: Bell-ringer sign, Spurling's test, Shoulder abduction test, or Cervical distraction test.\n* Imaging Criteria: X-ray findings (straight, lateral, or 3\u002F4 oblique views) showing at least one of the following:\n\n  1. Osteophytes (bone spurs) on the vertebral body.\n  2. Intervertebral disc space narrowing ≥ 25%.\n  3. Subchondral bone sclerosis.\n  4. Spondylolisthesis. - Traditional Chinese Medicine (TCM) Diagnosis (Wind-Cold Syndrome) Patients must satisfy at least one primary symptom and reach a total symptom score of ≥ 50% based on the following criteria:\n* Primary Symptoms: Pain in the neck and shoulder radiating to the arm accompanied by numbness; pain is the dominant feature; pain increases with cold and decreases with warmth.\n* Secondary Symptoms: Aversion to cold, aversion to wind, cold extremities, and presence or absence of sweating.\n* Tongue and Pulse: Pale tongue with a thin white coating; floating-tight or slow pulse.\n\nExclusion Criteria:\n\n* History of neck trauma.\n* Diagnosed with specific bone or joint diseases: Rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Down syndrome, cervical spina bifida, or Scheuermann's disease.\n* Severe motor or sensory radicular disorders: Muscle weakness or sensory disturbances such as burning, tingling, or numbness in the shoulder, arm, or hand.\n* Vertebral-basilar artery syndrome: Headache, dizziness, tinnitus, loss of balance, or fatigue.\n* Autonomic nervous system disorders: Pain accompanied by tinnitus, visual disturbances, or vasomotor disorders in the occipital-shoulder region or arms.\n* Central motor neuron lesions: Presence of Hoffmann's sign, Babinski's sign, hyperreflexia, spasticity, urinary\u002Ffecal incontinence, or sexual dysfunction.\n* Symptoms suggesting systemic or malignant disease: Unexplained weight loss, fever, loss of appetite, personal or family history of malignant tumors, or diffuse pain and stiffness.\n* Symptoms suggesting infection: Fever, meningeal signs, or photophobia.\n* Symptoms suggesting serious acute medical conditions: Myocardial infarction (chest pain + sweating + shortness of breath) or arterial dissection (tearing pain sensation + headache + blurred vision).\n* Local or systemic contraindications: Infection or ulceration at the acupuncture site; patients who are exhausted, emaciated, or suffering from severe accompanying internal medical diseases.\n* Substance abuse: Alcohol or drug addiction.\n* Recent medication use (within the past month): Currently using analgesics or anti-inflammatory drugs that may affect results, such as Opioids, NSAIDs, Corticosteroids, Gabapentin, Pregabalin, or tricyclic antidepressants.\n* Other ongoing treatments: Currently undergoing other therapies such as acupressure, massage, or physical therapy for the neck area.","18 Days",{"count":60,"type":24},74,[27],"Cervical spondylosis is a prevalent health issue that significantly impacts quality of life, with Cervical Spondylotic Radiculopathy (CSR) accounting for 60-70% of cases\n\n* While modern medicine offers various treatments, the frequent use of painkillers often leads to undesirable side effects\n* In Traditional Chinese Medicine, electroacupuncture is a safe and effective method recognized by the Ministry of Health for treating this condition\n* The \"Three-Needle Dazhui\" technique is a specialized acupuncture method that simultaneously uses three needles at the Dazhui (GV14) point to strongly activate Yang Qi and dispel cold, making it particularly suitable for the Wind-Cold syndrome. This study aims to evaluate whether the combination of the Three-Needle Dazhui technique and electroacupuncture yields better results in pain reduction and functional improvement compared to electroacupuncture alone in patients with cervical spondylosis and Wind-Cold syndrome.",[64,65,66,67],"Cervical Spondylosis","Wind-Cold Syndrome","Neck Pain","Cervical Spondylotic Radiculopathy","NOT_YET_RECRUITING","2026-06-08",{"date":71,"type":42},"2026-06-10",{"date":73,"type":24},"2026-06-01",{"date":75,"type":24},"2026-09",{"name":48,"class":49},{"id":78,"slug":79,"hasResults":12,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":25,"phases":87,"briefSummary":88,"conditions":89,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":94,"completionDateStruct":96,"leadSponsor":98,"locationsCount":4},"100637239","evaluation-of-the-therapeutic-efficacy-of-auricular-pellets-combined-with-atorvastatin-20mg-in-patients-with-dyslipidemia-and-phlegm-dampness-syndrome-100637239","NCT07624604","Evaluation of the Therapeutic Efficacy of Auricular Pellets Combined With Atorvastatin 20mg in Patients With Dyslipidemia and Phlegm-Dampness Syndrome","The Potential Efficacy of Auricular Pellets Combined With Atorvastatin 20mg in Managing Blood Lipid Levels and Improving Phlegm-Dampness Symptoms in 80 Patients With Dyslipidemia and Phlegm-Dampness Syndrome: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Diagnosis: Dyslipidemia (DL), untreated or discontinued treatment for at least 1 month, and not taking drugs that induce DL.\n* Laboratory Criteria: LDL-c levels between 2.6 and 4.9 mmol\u002FL.\n* TCM Criteria:\n\nDiagnosed with Phlegm-Dampness syndrome in patients with DL according to the \"Guiding Principles for Clinical Research on Combined Traditional Chinese and Western Medicine\":\n\nPrimary symptoms: Obesity, heavy sensation in the head, chest tightness, nausea\u002Fphlegm expectoration, numbness in limbs.\n\nSecondary symptoms: Palpitations, insomnia, bland taste in the mouth, poor appetite.\n\nTongue manifestations: Enlarged\u002Fflabby tongue, greasy\u002Fslippery tongue coating. Pulse: String-taut and slippery pulse (Wiry-Slippery pulse). Diagnostic threshold: Confirmed when presenting \\>= 50% of TCM Phlegm-Dampness syndrome symptoms in patients with DL.\n\nExclusion Criteria:\n\n* Participants are non-compliant with the treatment protocol.\n* Participants decline to continue study participation for any reason (Withdrawal of consent).\n* Participants experience health events during the study and do not wish to continue participation.","75 Years",{"count":86,"type":24},80,[27],"Dyslipidemia (DL) is a metabolic disorder characterized by an imbalance of blood lipid components, serving as a leading silent cause of dangerous cardiovascular diseases and increased mortality risk globally. According to the World Health Organization (WHO), cardiovascular diseases account for 32% of all deaths worldwide, with dyslipidemia playing a crucial role in the pathogenesis of 85% of fatalities caused by heart attacks and strokes. Although current management primarily relies on lifestyle modifications and lipid-lowering medications such as statins, fibrates, or niacin, some patients still encounter difficulties due to inadequate treatment response, adverse side effects, or poor long-term compliance. In this context, Traditional Chinese Medicine (TCM) therapies are increasingly being widely applied, either as monotherapy or in combination with Western medicine. Notably, auricular acupuncture-a method focusing on specific acupoints on the ear-has been recognized for its great potential in modulating lipid profiles, particularly demonstrating therapeutic efficacy in patients with Phlegm-Dampness syndrome.\n\nTheoretically and clinically, Phlegm-Dampness syndrome is inextricably linked to the pathogenesis and progression of dyslipidemia (DL); furthermore, clinical research in China indicates that the Phlegm pattern accounts for the highest proportion among the five traditional syndromes of this condition, and a greater severity of Phlegm-Dampness correlates positively with higher levels of TC and LDL-c. In terms of treatment, auricular pellets (a modality of auricular acupuncture) have been demonstrated to improve cardiovascular health by reducing TC, LDL-c, and TGR levels while elevating HDL-c in obese patients with mild-to-moderate DL. In Vietnam, however, studies evaluating the application of auricular pellets in patients with DL remain limited, primarily focusing on individuals with simple overweight or obesity without documented concurrent metabolic disorders. Notably, a study by Nguyen Vu Thien Duyen (2021) reported that a 3-acupoint formula consisting of Hunger (TGR3), Stomach (CO4), and Endocrine (CO18) effectively reduced lipid profiles to a moderate extent in obese individuals.\n\nGiven the limitations in evaluating therapeutic efficacy and the scarcity of published studies discussing the effects of lowering blood lipid profiles and alleviating Phlegm-Dampness symptoms for this specific pattern in Vietnam, the investigators conducted this study to evaluate the degree of lipid profile reduction and the clinical symptom improvement of the Phlegm-Dampness syndrome using auricular acupuncture in patients with dyslipidemia presenting with the Phlegm-Dampness syndrome.",[90],"Phlegm-Dampness Syndrome","2026-05-28",{"date":93,"type":42},"2026-06-03",{"date":95,"type":24},"2026-05-15",{"date":97,"type":24},"2026-10",{"name":48,"class":49},{"id":100,"slug":101,"hasResults":12,"nctId":102,"briefTitle":103,"officialTitle":104,"acronym":4,"eligibilityCriteria":105,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":106,"enrollmentInfo":107,"targetDuration":4,"studyType":25,"phases":109,"briefSummary":110,"conditions":111,"keywords":114,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":120,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":50},"100639109","catgut-embedding-for-lumbar-spondylosis-with-blood-stasis-syndrome-100639109","NCT07590050","Catgut Embedding for Lumbar Spondylosis With Blood Stasis Syndrome","Evaluating the Efficacy of Catgut Embedding Therapy in Pain Relief and Quality of Life Improvement for Lumbar Spondylosis With Blood Stasis Syndrome","Inclusion Criteria:\n\n* Age and Gender: Patients aged 18 to 65 years, regardless of gender.\n* Diagnosis of Chronic Low Back Pain: Confirmed diagnosis of low back pain due to lumbar spondylosis with the following criteria:\n\n  * Clinical: Mechanical spinal pain.\n  * Radiographic (X-ray): Joint space narrowing, subchondral sclerosis, and osteophytes on the vertebral bodies.\n  * Absence of systemic symptoms such as fever, unexplained weight loss, or anemia.\n* Duration: Pain duration exceeding 3 months.\n* Pain Intensity: Visual Analog Scale (VAS) score for low back pain \\> 40 mm.\n* Traditional Medicine Diagnosis: Diagnosed with Low back pain under the \"Blood Stasis\" syndrome according to Decision No. 5013\u002FQD-BYT (2020) by the Ministry of Health: Pain occurs after heavy lifting or sudden movement. Severe localized pain, pain increases with movement\u002Fpressure. Limited range of motion. Tongue: Purple or with stasis points. Pulse: Choppy.\n* Communication: Capable of communicating fluently in Vietnamese to complete survey questionnaires.\n* Consent: Volunteers who agree to participate and sign the Informed Consent Form.\n\nExclusion Criteria:\n\n* Neurological Deficits: Patients with clinical neurological abnormalities in the lower limbs.\n* Surgical Indications: Patients with indications for spinal surgery due to severe neurological deficits.\n* Co-morbidities: Vertebral fractures, spinal inflammation\u002Finfection, malignant tumors, neuromuscular scoliosis, or degenerative neurological diseases.\n* Hypersensitivity: History of hypersensitivity or adverse reactions to electro-acupuncture or catgut embedding treatments.","65 Years",{"count":108,"type":24},66,[27],"The goal of this clinical trial is to learn if catgut embedding works to treat chronic low back pain in adults with lumbar spondylosis and \"Blood Stasis\" syndrome. The main questions it aims to answer are:\n\nDoes catgut embedding lower back pain more effectively than electro-acupuncture?\n\nDoes catgut embedding improve the daily physical activities of participants?\n\nResearchers will compare catgut embedding to electro-acupuncture to see which method works better to reduce pain and improve quality of life. All participants will also receive counseling on lifestyle changes and back exercises.\n\nParticipants will:\n\nBe randomly assigned to receive either catgut embedding (2 sessions over 4 weeks) or electro-acupuncture (20 sessions over 4 weeks).\n\nVisit the clinic for treatments and checkups.\n\nComplete surveys about their pain levels and ability to perform daily tasks at the start, at 2 weeks, and at 4 weeks.",[112,113],"Lumbar Spondylosis","Low Back Pain",[115,116,117,118,119],"Catgut Embedding","Electro-acupuncture","Polydioxanone (PDO)","Traditional Vietnamese Medicine","Blood Stasis Syndrome","2026-05-10",{"date":95,"type":42},{"date":123,"type":42},"2026-03-11",{"date":125,"type":24},"2026-10-30",{"name":48,"class":49},{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":12,"sex":19,"minAge":134,"maxAge":84,"enrollmentInfo":135,"targetDuration":4,"studyType":25,"phases":137,"briefSummary":138,"conditions":139,"keywords":141,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":50},"100635440","thread-embedding-plus-auricular-acupressure-for-non-organic-insomnia-based-on-traditional-medicine-pattern-differentiation-100635440","NCT07552714","Thread Embedding Plus Auricular Acupressure for Non-Organic Insomnia Based on Traditional Medicine Pattern Differentiation","Evaluation of the Efficacy of Thread Embedding Acupuncture Combined With Auricular Acupressure Based on Traditional Chinese Medicine Clinical Syndromes in Patients With Non-Organic Insomnia","Inclusion Criteria:\n\n* Age: 40 to 75 years.\n* Cognitive Function: Mini-Mental State Examination (MMSE) score \\> 24.\n* Stable Comorbidities: Participants with hypertension or diabetes must be well-controlled with medication (Blood Pressure \\\u003C 140\u002F90 mmHg, HbA1c \\\u003C 7%) and have no changes in their medication regimen within the last 3 months.\n* Modern Medical Criteria: Diagnosis of Chronic Insomnia Disorder according to the International Classification of Sleep Disorders, 3rd Edition (ICSD-3).\n* Sleep Quality Scores: A Pittsburgh Sleep Quality Index (PSQI) score \\>= 5 and a total Insomnia Severity Index (ISI) score \\>= 10.\n* TCM Syndrome: Diagnosed with one of the following Traditional Chinese Medicine syndromes: Heart-Spleen Deficiency, Liver Qi Stagnation, or Liver Qi Stagnation with Spleen Deficiency.\n* Informed Consent: Participants must voluntarily sign the informed consent form and agree to comply with study requirements, including stool sample collection.\n\nExclusion Criteria:\n\n* Secondary Insomnia: Sleep disturbances caused by organic conditions (e.g., brain tumor, acute pain, hyperthyroidism, or severe cardiovascular disease).\n* Gastrointestinal Disorders: Current acute or chronic gastrointestinal diseases (e.g., ulcerative colitis, Crohn's disease, or acute diarrhea).\n* Specific Medications and Supplements: \\* Use of antibiotics, corticosteroids, or Probiotic\u002FPrebiotic supplements within 4 weeks prior to the study.\n* Use of Proton Pump Inhibitors (PPIs) such as Omeprazole or Esomeprazole within the last 2 weeks.\n* Regular use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) such as Ibuprofen, Meloxicam, or Diclofenac.\n* Medical Procedures: Enema or colonoscopy performed within 1 month prior to the study.\n* Immune Conditions: Autoimmune diseases or rheumatoid arthritis.\n* Vaccination: Vaccination (e.g., influenza vaccine) within 2 weeks prior to blood collection.\n* Advanced Chronic Diseases: Late-stage chronic conditions including renal failure (eGFR \\\u003C 45), liver failure, or stage III-IV heart failure.\n* Severe Nocturia: Urinating \\>= 3 times per night.\n* Obstructive Sleep Apnea (OSA): Patients with obesity, loud snoring, and excessive daytime sleepiness.\n* Pregnancy and Lactation: Women who are pregnant or breastfeeding.","40 Years",{"count":136,"type":24},70,[27],"Non-organic insomnia is a prevalent disorder that significantly impairs quality of life, characterized by difficulty initiating or maintaining sleep alongside daytime functional decline. This condition is particularly common among adults facing chronic stress, which increases the risk of chronic diseases and dysregulates the Microbiota-Gut-Brain Axis (MGBA)-a bidirectional communication system between the central nervous system and the gut microbiota. Prolonged sleep deprivation and stress can trigger inflammatory responses and gut dysbiosis, which in turn exacerbate emotional and sleep disturbances. While conventional sedative-hypnotics often carry side effects and risks of dependency, traditional medicine interventions are emerging as potential sustainable solutions. This study evaluates the efficacy of thread embedding combined with auricular acupressure based on individualized traditional Chinese medicine syndrome differentiation, while clarifying the relationship between clinical sleep improvement and changes in MGBA-related inflammatory markers, specifically interleukin-6 and calprotectin.\n\nThe goal of this clinical trial is to evaluate the clinical efficacy and preliminarily investigate the mechanisms of action-via the Microbiota-Gut-Brain Axis-of individualized Traditional Chinese Medicine (targeting Heart-Spleen Deficiency and Liver Qi Stagnation syndromes) using thread embedding acupuncture combined with auricular acupressure to improve sleep quality in patients with insomnia, compared to a non-individualized protocol. The main questions it aims to answer are:\n\n* Does the combined method of thread embedding acupuncture and auricular acupressure based on syndrome differentiation improve sleep quality more effectively than the standardized protocol?\n* Is there a significant difference in the change of IL-6 and Calprotectin levels following treatment in the intervention group compared to the control group?\n* Does post-treatment clinical improvement correlate with the reduction of these inflammatory markers?\n\nParticipants will:\n\n* Receive thread embedding acupuncture sessions every 4 weeks and have ear seeds (auricular acupressure) replaced every 2 weeks . Self-massage the ear seeds for 1 to 2 minutes several times each day, especially before bedtime.\n* Complete assessments of sleep quality (PSQI, ISI) and digestive health (GSRS) every 2 weeks through week 8.\n* Provide blood and stool samples at the start and end of the study to measure inflammation markers.\n* Be monitored for any adverse effects, such as local pain, dizziness, or needle fainting, during the trial period.",[140],"Insomnia, Nonorganic",[142,143,144,145,146,147,148],"non-organic insomnia","thread embedding acupuncture","auricular acupressure","TCM Syndrome","Interleukin 6","Calprotectin","Gut-brain axis","2026-05-05",{"date":151,"type":42},"2026-05-08",{"date":153,"type":24},"2026-05-01",{"date":155,"type":24},"2027-12",{"name":48,"class":49},{"id":158,"slug":159,"hasResults":12,"nctId":160,"briefTitle":161,"officialTitle":162,"acronym":4,"eligibilityCriteria":163,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":164,"enrollmentInfo":165,"targetDuration":4,"studyType":25,"phases":167,"briefSummary":168,"conditions":169,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":175,"leadSponsor":176,"locationsCount":4},"100635945","efficacy-of-jins-three-needle-technique-combined-with-electroacupuncture-in-cervical-spondylosis-with-blood-stasis-syndrome-100635945","NCT07559279","Efficacy Of Jin's Three-Needle Technique Combined With Electroacupuncture In Cervical Spondylosis With Blood Stasis Syndrome","The Potential Efficacy Of Jin's Three-Needle Technique Combined With Electroacupuncture In Managing Pain And Improving Cervical Active Range Of Motion In 104 Patients With Cervical Spondylosis And Blood Stasis Syndrome: A Randomized, Single-Blind, Controlled Trial","Inclusion Criteria:\n\n* Individuals between the ages of 18 and 70 years.\n* Patients diagnosed with cervical spondylosis based on clinical symptoms (mechanical neck pain increasing with movement and decreasing at rest, continuous or episodic pain, restricted cervical movement) and subclinical criteria (at least one imaging evidence from X-ray or MRI showing cervical spondylosis).\n* Patients diagnosed with Blood Stasis syndrome according to the 2002 Guidelines for Clinical Research of New Traditional Chinese Medicines. • Diagnosis requires \\>50% of the symptoms and at least one primary symptom. Primary symptoms include onset after neck trauma, stiff neck pain increasing with movement, and a fixed pain point. Secondary symptoms include limb numbness, pale pink or dark purple tongue with stasis spots, and a string-taut or choppy pulse.\n* Individuals with an average pain score from 3 to less than 8 (3 ≤ VAS \\\u003C 8) on the Visual Analogue Scale.\n* Individuals who volunteered to participate in the study and signed a consent form.\n\nExclusion Criteria:\n\n* Patients diagnosed with acute or chronic neck pain due to specific causes (infection, tumor, osteoporosis, ankylosing spondylitis, fracture, disc herniation) or those having root compression syndrome, spinal cord compression syndrome, or vertebral artery syndrome.\n* Patients with a history of neck trauma, cervical spine fracture or surgery, congenital spinal abnormalities, or systemic bone and joint diseases.\n* Patients who have used medications affecting the study results within 1 week prior, including painkillers (Paracetamol, Tramadol, NSAIDs, Gabapentin, Pregabalin), muscle relaxants (Eperisone, Tolperisone), or traditional medicine for neck pain.\n* Patients with contraindications to electroacupuncture according to the Ministry of Health guidelines, such as cachexia, decreased resistance, pregnancy, skin infection or ulceration at acupoints, prolonged fever, dehydration, blood loss, emergency conditions, heart failure, arrhythmia, or surgical causes of neck pain.\n* Patients with mental illness or who are not fully conscious.\n* Patients with a pacemaker or metal devices such as nails or splints.\n* Patients currently using anticoagulants or having hemophilia.\n* Patients currently participating in another interventional study","70 Years",{"count":166,"type":24},104,[27],"Neck pain is a highly prevalent condition, affecting 30% to 50% of the population, with cervical spondylosis accounting for up to 80% of these cases. The burden of cervical spondylosis continues to increase, leading to chronic mechanical pain, restricted mobility, and a significant socioeconomic impact. Treatment mainly includes non-steroidal anti-inflammatory drugs (NSAIDs), physical therapy, and traditional medicine therapies such as massage and acupuncture.\n\nJin's Three-Needle technique (specifically Cervical Three-Needle targeting Dazhu, Tianzhu, and Bailao acupoints) is a specialized acupuncture method created by Professor Jin Rui, demonstrating therapeutic effectiveness in improving local circulation and relieving neck pain. Recent studies have shown that acupuncture effectively manages pain in cervical spondylosis, especially for the Blood Stasis syndrome. Additionally, combining these specific acupoints with standard electroacupuncture and active movement exercises plays an essential role in alleviating pain and restoring cervical spine function. In practice, many practitioners apply Jin's Three-Needle technique to treat cervical spondylosis with considerable effectiveness, though it has not been thoroughly evidence-based in Vietnam for the Blood Stasis syndrome.\n\nGiven the limitations in evaluating treatment effectiveness and the lack of published research discussing the analgesic effects of Jin's Three-Needle technique for this specific syndrome in Vietnam , the investigators conducted the study to evaluate the pain reduction and range of motion improvement of Jin's Three-Needle technique combined with electroacupuncture in patients with cervical spondylosis with blood stasis syndrome.",[170],"Pain","2026-05-03",{"date":173,"type":42},"2026-05-07",{"date":95,"type":24},{"date":97,"type":24},{"name":48,"class":49},{"id":178,"slug":179,"hasResults":12,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":184,"targetDuration":4,"studyType":25,"phases":185,"briefSummary":186,"conditions":187,"keywords":4,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":191,"startDateStruct":192,"completionDateStruct":193,"leadSponsor":195,"locationsCount":50},"100639595","efficacy-of-auricular-acupressure-combined-with-antihistamines-in-patients-with-wind-heat-type-urticaria-100639595","NCT07575464","Efficacy of Auricular Acupressure Combined With Antihistamines in Patients With Wind-Heat Type Urticaria.","Evaluation of the Efficacy of Auricular Acupressure Combined With Antihistamines in Patients With Wind-Heat Type Urticaria","Inclusion Criteria:\n\n* Diagnosed with urticaria according to the international EAACI\u002FGA²LEN\u002FEuroGuiDerm\u002FAPAAACI 2022 guidelines.\n* Presenting typical clinical symptoms of urticaria.\n* Experiencing persistent itching and wheals, with an Urticaria Activity Score (UAS) indicating an itching and discomfort level of ≥ 1.\n* Diagnosed with the Wind-Heat syndrome according to Traditional Medicine criteria by a certified practitioner. Diagnosis requires the presence of main symptoms (persistent itchy rash, intense itching, bright red wheals) and at least 2 secondary symptoms (restlessness, feverish sensation, aversion to heat, sore throat, symptoms worsening with heat, thin yellow tongue coating, floating rapid pulse).\n* Voluntarily agrees to participate and signs the informed consent form.\n\nExclusion Criteria:\n\n* Having contraindications to auricular acupressure according to the Ministry of Health, including severe physical exhaustion or immunodeficiency.\n* Having skin infections, inflammation, or ulceration at the auricular acupoint areas.\n* Experiencing acute pain suspected to be of surgical origin or in an emergency condition.\n* Pregnant women.\n* Use of stimulants (alcohol, beer, coffee, tobacco) within 24 hours prior to the study intervention.\n* Severe cognitive impairment or inability to understand the study protocol.\n* History of allergy or hypersensitivity to second-generation H1 antihistamines.\n* Currently participating in another interventional clinical study.",{"count":108,"type":24},[27],"The purpose of this clinical trial is to evaluate the efficacy of auricular acupressure combined with an antihistamine (Loratadine) in treating patients diagnosed with Wind-Heat type urticaria. Participants will be randomly assigned to either the intervention group or the control group.\n\nThe purpose of this clinical trial is to evaluate the efficacy of auricular acupressure combined with an antihistamine (Loratadine) in treating patients diagnosed with Wind-Heat type urticaria. Participants will be randomly assigned to either the intervention group or the control group.\n\nThe main questions the study aims to answer are:\n\n* Does true auricular acupressure combined with Loratadine reduce urticaria symptoms (measured by the Urticaria Activity Score - UAS) more effectively than sham acupressure with Loratadine?\n* Does the intervention improve the patients' quality of life (measured by the Dermatology Life Quality Index - DLQI) better than the control treatment?\n* Are there any adverse effects associated with the auricular acupressure treatment during the intervention period?\n\nParticipants will:\n\n* Take a standard daily dose of oral Loratadine (10mg).\n* Visit the clinic once a week for 4 weeks to have Vaccaria seed patches applied to their ear (either true therapeutic points or sham points, depending on their assigned group).\n* Self-stimulate the acupoints by pressing the patches for 1 to 2 minutes, 2 to 3 times a day at home.\n* Record their daily urticaria symptoms (wheals and pruritus) using the Urticaria Activity Score (UAS).\n* Complete the Dermatology Life Quality Index (DLQI) questionnaire at the beginning and at the end of the 4-week study period.",[188,189,190],"Auricular Acupressure","Wind-Heat Urticaria","Traditional Medicine",{"date":151,"type":42},{"date":153,"type":24},{"date":194,"type":24},"2026-07",{"name":48,"class":49},{"id":197,"slug":198,"hasResults":12,"nctId":199,"briefTitle":200,"officialTitle":201,"acronym":4,"eligibilityCriteria":202,"healthyVolunteers":12,"sex":19,"minAge":203,"maxAge":204,"enrollmentInfo":205,"targetDuration":4,"studyType":25,"phases":207,"briefSummary":208,"conditions":209,"keywords":212,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":223,"completionDateStruct":225,"leadSponsor":227,"locationsCount":228},"100635837","healing-efficacy-of-diode-laser-in-lingual-frenectomy-100635837","NCT07557875","Healing Efficacy of Diode Laser in Lingual Frenectomy","Evaluation of the Healing Efficacy of Diode Laser in Lingual Frenectomy","Inclusion Criteria:\n\n* Patients aged between 3 and 6 years.\n* Diagnosed with grade 3 or grade 4 ankyloglossia according to Kotlow's classification (1999).\n* Parents or legal guardians provide informed consent for the child to participate in the study.\n* Patients and guardians agree to follow the follow-up schedule (24 hours, 3 days, 1 week, and 1 month post-surgery).\n\nExclusion Criteria:\n\n* History of allergy to local anesthetics (e.g., Lidocaine, Adrenaline).\n* Patients with systemic diseases or high-risk surgical factors (e.g., cardiovascular disease, bleeding disorders, hemophilia, epilepsy, or uncontrolled asthma).\n* Uncooperative patients who are unable to undergo the procedure under local anesthesia or fail to follow post-operative instructions.\n* Patients who withdraw from the study before completion.","3 Years","6 Years",{"count":206,"type":24},53,[27],"This study aims to compare the wound healing efficacy and postoperative experiences between the 940 nm diode laser technique and the traditional electrosurgery method for treating ankyloglossia (tongue-tie) in children aged 3 to 6 years.\n\nParticipants are randomly assigned to one of two groups: Experimental Group - Patients undergo lingual frenectomy using a 940 nm diode laser and Active Comparator Group - Patients undergo the procedure using conventional high-frequency electrosurgery.\n\nThe study evaluates several key outcomes at multiple intervals (24 hours, 3 days, 1 week, and 1 month post-surgery), including: (1) Wound Healing: Measured by the Early Wound Healing Score (EHS); (2) Pain Levels: Assessed using the Wong-Baker FACES Pain Rating Scale; (3) Bleeding Control: Evaluation of intraoperative bleeding; (4) Tongue Mobility: Measurement of free tongue length according to Kotlow's classification.\n\nThe goal is to determine if the diode laser provides superior healing, less pain, and better bleeding control compared to electrosurgery.",[210,211],"Ankyloglossia","Tongue-tie",[210,211,213,214,215,216,217,218,219,220],"Lingual frenectomy","Diode laser","Electrosurgery","Wound healing","Postoperative pain","Early Wound Healing Score (EHS)","Wong-Baker FACES Pain Rating Scale","Kotlow's classification","2026-04-22",{"date":44,"type":42},{"date":224,"type":42},"2024-10-01",{"date":226,"type":24},"2026-10-01",{"name":48,"class":49},2,{"id":230,"slug":231,"hasResults":12,"nctId":232,"briefTitle":233,"officialTitle":234,"acronym":4,"eligibilityCriteria":235,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":25,"phases":238,"briefSummary":239,"conditions":240,"keywords":241,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":253},"100634776","acupuncture-with-five-shu-points-for-insomnia-in-heart-spleen-deficiency-100634776","NCT07544082","Acupuncture With Five Shu Points for Insomnia in Heart-Spleen Deficiency","Efficacy of Five Shu Point Acupuncture in the Treatment of Insomnia in Patients With Heart-Spleen Deficiency Pattern: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 18 years or older who voluntarily consent to participate in the study.\n* Patients who have never used or have discontinued insomnia medication within 2 weeks prior to study enrollment.\n* Patients meeting the diagnostic criteria for insomnia according to the DSM-V of the American Psychiatric Association, specifically as follows:\n\nA. The patient complains about sleep quantity or quality, including one or more of the following symptoms: difficulty initiating sleep; difficulty maintaining sleep, characterized by frequent awakenings or trouble returning to sleep after awakening; early morning awakening with inability to return to sleep.\n\nB. Sleep difficulty occurs for at least 3 months. C. Sleep disturbance causes significant distress or impairment in social, occupational, educational, academic, behavioral, or other important areas of functioning.\n\nD. Sleep difficulty occurs at least 3 nights per week. E. Sleep difficulty occurs despite adequate opportunity for sleep. F. Insomnia is not better explained by another sleep disorder (e.g., narcolepsy, breathing-related sleep disorder, circadian rhythm sleep disorder).\n\nG. Co-existing mental disorders or medical conditions do not adequately explain the predominant complaint of insomnia.\n\nH. Insomnia is not attributable to the physiological effects of a substance.\n\n* Patients who are able to understand Vietnamese.\n* Patients meeting the diagnostic criteria for Heart-Spleen dual deficiency syndrome according to Jing Lv, requiring the presence of mandatory symptoms + 2 primary symptoms + 2 secondary symptoms + tongue and pulse findings, specifically:\n\nMandatory symptoms\n\n* Sleeplessness throughout the night, or light sleep with frequent awakening; fragmented sleep.\n* Frequent nightmares.\n* Early morning awakening with inability to fall back asleep.\n\nPrimary symptoms\n\nPalpitations, forgetfulness. Mental fatigue, poor appetite. Pale, unhealthy complexion. Secondary symptoms\n\nDizziness, blurred vision. Weakness of limbs. Abdominal distension, loose stools. Tongue and pulse findings\n\nPale tongue with thin white coating. Thin, weak, forceless pulse.\n\nExclusion Criteria:\n\n* Patients diagnosed with other sleep disorders such as sleep apnea syndrome or narcolepsy.\n* Patients previously diagnosed with neurological or psychiatric disorders (e.g., anxiety disorder, autism spectrum disorder, depression, obsessive-compulsive disorder, rapid eye movement sleep behavior disorder) prior to study enrollment.\n* Patients currently using antidepressants or psychiatric medications.\n* Patients participating in other clinical trials involving behavioral, psychological, or complementary medical interventions during the study period.\n* The patient no longer agrees to continue participation.\n* Occurrence of uncomfortable symptoms during the study, such as needle syncope, nausea, headache, dizziness, sweating, etc.\n* Significant worsening of the condition or development of new complications.\n* Non-adherence to the treatment protocol, making continuation impossible.",{"count":237,"type":24},46,[27],"This study was designed as a randomized controlled trial (RCT) with a multicenter, single-blind methodology. Participants diagnosed with insomnia attributable to the Heart-Spleen Deficiency pattern, receiving treatment at the Ho Chi Minh City Hospital of Traditional Medicine and Hospital 1A, were randomly allocated into two groups.",[140],[242,243,244,245],"Five-Shu acupoints","insomnia","acupuncture","Heart-Spleen deficiency","2026-04-19",{"date":221,"type":42},{"date":249,"type":42},"2026-03-01",{"date":251,"type":24},"2026-09-10",{"name":48,"class":49},3,{"id":255,"slug":256,"hasResults":12,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":164,"enrollmentInfo":261,"targetDuration":4,"studyType":25,"phases":263,"briefSummary":264,"conditions":265,"keywords":268,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":272,"lastUpdatePostDateStruct":273,"startDateStruct":274,"completionDateStruct":275,"leadSponsor":277,"locationsCount":228},"100634907","electroacupuncture-and-cupping-for-shoulder-tendinitis-100634907","NCT07545785","Electroacupuncture and Cupping for Shoulder Tendinitis","Effectiveness of Electroacupuncture Combined With Cupping Therapy in Patients With Shoulder Tendinitis and qi Stagnation and Blood Stasis Syndrome","Inclusion Criteria:\n\n* Patients between 18 and 70 years old.\n* Pain intensity score on the Visual Analogue Scale (VAS) between 4 and 7.\n* Diagnosis of rotator cuff and\u002For long head of the biceps tendonitis according to the guidelines issued by the Ministry of Health of Vietnam.\n* Mechanical pain that increases during movements such as abduction or raising the arm.\n* Presence of tender points at the long head of the biceps tendon or supraspinatus tendon .\n* Pain that increases during resisted contraction tests, such as the Jobe test or Palm-up test.\n* Absence of limitation in the passive range of motion of the shoulder.\n* Ultrasound findings showing a hypoechoic tendon or evidence of calcification.\n* Absence of motor weakness or paralysis.\n* Diagnosis of the TCM syndrome \"Qi Stagnation and Blood Stasis\"\n\nExclusion Criteria:\n\n* Patients who do not agree to participate in the study.\n* Diagnosis of pseudo-paralysis, acute calcific periarthritis, or frozen shoulder.\n* Shoulder pain caused by cervical nerve root lesions.\n* Shoulder pain originating from apical lung tumors, coronary artery disease, or myocardial infarction.\n* Specific joint lesions caused by infection, tuberculosis, or rheumatoid arthritis.\n* Bone pathologies including fractures, dislocations, or osteonecrosis of the humeral head.\n* Shoulder dysfunction resulting from stroke or hemiplegia.\n* Women who are pregnant.\n* Patients with mental illness.\n* Contraindications for vacuum cupping, such as acute skin inflammation, open wounds, or alcohol consumption.\n* Contraindications for electroacupuncture, including cardiac pacemakers, heart failure, or local skin ulcers.\n* Current participation in another intervention study.\n* Use of painkillers, muscle relaxants, or within the last week.\n* Use of anticoagulants or a history of hemophilia.",{"count":262,"type":24},54,[27],"This study aims to evaluate the effectiveness of electroacupuncture combined with vacuum cupping therapy in treating simple periarthritis of the shoulder associated with the traditional medicine syndrome of Qi stagnation and blood stasis. Shoulder periarthritis is a common condition that causes pain, stiffness, and limited movement of the shoulder due to injury or inflammation of the muscles, tendons, ligaments, and surrounding soft tissues. It can interfere with daily activities such as dressing, lifting objects, sleeping, and working.\n\nElectroacupuncture is commonly used to relieve shoulder pain and improve shoulder function. Vacuum cupping therapy is another non-drug treatment that may help improve blood circulation, reduce muscle tightness, decrease pain, and improve mobility. However, there is currently limited evidence about whether combining electroacupuncture with vacuum cupping provides better results than electroacupuncture alone in patients with shoulder periarthritis and Qi stagnation-blood stasis syndrome. This study is being conducted to determine whether the combined treatment is more effective and safe.\n\nA total of 54 participants with simple shoulder periarthritis and Qi stagnation-blood stasis syndrome will be enrolled in the study. Participants will be randomly assigned to one of two groups:\n\nGroup 1: treatment with electroacupuncture alone. Group 2: treatment with electroacupuncture combined with vacuum cupping therapy.\n\nAll participants will also receive advice on shoulder exercises, posture, and daily activities to support recovery. Treatments will be performed by licensed traditional medicine practitioners.\n\nEach participant will take part in the study for two weeks. Assessments will be performed before treatment, after one week, and after two weeks. The study will evaluate:\n\nPain intensity using the Visual Analogue Scale (VAS). Shoulder pain and disability using the Shoulder Pain and Disability Index (SPADI).\n\nShoulder range of motion using the McGill-McRomi Range of Motion Index. Any side effects or unwanted events related to treatment. Possible benefits of participating in this study include reduced shoulder pain, improved movement and daily function, and close monitoring by health care professionals. Participants may also benefit from receiving non-drug therapies at no cost during the study period. The findings of this research may help improve future treatment options for patients with shoulder pain.\n\nPossible risks of electroacupuncture include mild pain at the needle site, minor bleeding, bruising, dizziness, or fainting. Possible risks of vacuum cupping include temporary discomfort, skin redness, bruising, or mild pain in the treated area. These side effects are usually mild and temporary. If any unexpected problem occurs, participants will receive prompt medical attention.\n\nParticipation in this study is completely voluntary. Participants may refuse to join or may withdraw from the study at any time without affecting their usual medical care. All personal information collected during the study will remain confidential and will only be used for research purposes.",[266,267],"Shoulder Tendinopathy","Shoulder Tendinitis",[269,270,271,267],"shoulder tendinopathy","Rotator cuff tendinitis","Long head of the biceps tendonitis","2026-04-16",{"date":221,"type":42},{"date":249,"type":42},{"date":276,"type":24},"2026-11-15",{"name":48,"class":49},{"id":279,"slug":280,"hasResults":12,"nctId":281,"briefTitle":282,"officialTitle":283,"acronym":4,"eligibilityCriteria":284,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":285,"enrollmentInfo":286,"targetDuration":4,"studyType":25,"phases":288,"briefSummary":289,"conditions":290,"keywords":292,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":294,"lastUpdatePostDateStruct":295,"startDateStruct":297,"completionDateStruct":299,"leadSponsor":300,"locationsCount":4},"100634265","evaluation-of-the-adjunctive-effects-of-moxibustion-in-the-treatment-of-cold-syndrome-allergic-rhinitis-100634265","NCT07537439","Evaluation of the Adjunctive Effects of Moxibustion in the Treatment of Cold-Syndrome Allergic Rhinitis","Evaluation Of The Adjunctive Effects Of Moxibustion In The Treatment Of Cold-Syndrome Allergic Rhinitis","Inclusion Criteria:\n\n* Adults aged 18 to 60 years.\n* Diagnosed with allergic rhinitis according to ARIA guidelines.\n* Presence of typical nasal symptoms such as sneezing, rhinorrhea, nasal obstruction, or nasal itching.\n* Classified as cold-related syndrome according to traditional medicine assessment.\n* Indicated for treatment with intranasal corticosteroids.\n* Willing and able to provide written informed consent.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding individuals.\n* Severe nasal structural abnormalities or nasal polyps.\n* History of asthma or other significant chronic respiratory diseases.\n* Known allergy or intolerance to moxibustion smoke or study medications.\n* Severe comorbid medical conditions that may interfere with study participation.\n* Inability to comply with study procedures.","60 Years",{"count":287,"type":24},60,[27],"Allergic rhinitis (AR) is an inflammatory disease of the nasal mucosa characterized by one or more of the following symptoms: nasal obstruction, rhinorrhea, sneezing, and nasal itching. It is an IgE-mediated immune disorder that typically occurs after exposure to allergens such as pollen, house dust mites, and animal dander. The reported prevalence of rhinitis in adults ranges widely from 1% to over 60%, largely depending on diagnostic definitions and geographic regions. Allergic rhinitis is estimated to affect approximately 10% to 30% of the global population and imposes a substantial burden on sleep quality, quality of life, cognitive function, and work productivity.\n\nDue to its chronic course, frequent recurrence, and complex pathophysiology, allergic rhinitis not only adversely affects patients' physical and mental health and overall quality of life but also results in significant socioeconomic burden. Current standard management strategies include allergen avoidance and pharmacological treatments such as oral and intranasal antihistamines, leukotriene receptor antagonists, and intranasal glucocorticoids. However, despite stepwise treatment approaches, a considerable proportion of patients continue to experience persistent symptoms and impaired quality of life, and may suffer from medication-related adverse effects, including drowsiness, dryness of the nasal or ocular mucosa, and nasal irritation.\n\nAllergen-specific immunotherapy is currently regarded as the only disease-modifying treatment for allergic rhinitis. Nevertheless, its long treatment duration, high cost, requirement for medical supervision, and variable patient response substantially limit accessibility and long-term adherence, particularly in low- and middle-income countries. In this context, there is an increasing need to identify adjunctive therapeutic approaches that are safe, effective, cost-efficient, and culturally acceptable.\n\nTraditional medicine has been widely applied in the management of allergic rhinitis in many countries, including Vietnam. Therapeutic modalities such as acupuncture, moxibustion, thread embedding therapy, and herbal medicine have been reported to alleviate symptoms, reduce recurrence rates, improve quality of life, and decrease reliance on pharmacological treatments.\n\nMoxibustion is a traditional therapeutic technique that applies heat generated by burning moxa sticks or moxa cones to specific acupuncture points, with the aim of regulating Qi and blood, strengthening vital energy, and enhancing the body's resistance to disease. This method is generally considered safe, easy to administer, low-cost, and suitable for implementation in community settings and primary health-care facilities. Several clinical studies worldwide have demonstrated that moxibustion can significantly improve symptoms of allergic rhinitis with a low incidence of adverse effects.\n\nHowever, high-quality scientific evidence regarding the efficacy and safety of moxibustion in the treatment of allergic rhinitis remains limited. In particular, there is a lack of well-designed and standardized randomized controlled trials. In Vietnam, although moxibustion is commonly used in traditional medicine practice, no clinical studies to date have systematically evaluated its effectiveness and safety in patients with allergic rhinitis. This gap in evidence highlights the need for rigorously designed clinical studies to strengthen the scientific basis, standardize treatment protocols, support the integration of moxibustion into clinical practice, and guide the development of integrative treatment models combining conventional medicine and traditional medicine in the management of allergic rhinitis.\n\nBased on these considerations, the present study is conducted to evaluate the efficacy and safety of moxibustion in the treatment of allergic rhinitis, with the aim of providing additional clinical evidence, improving treatment quality, and optimizing disease management for patients.",[291],"Allergic Rhinitis (AR)",[293],"Allergic rhinitis; Moxibustion; Mild moxibustion; Traditional medicine; Complementary therapy; Cold syndrome","2026-04-12",{"date":296,"type":42},"2026-04-17",{"date":298,"type":24},"2026-04-13",{"date":226,"type":24},{"name":48,"class":49},{"id":302,"slug":303,"hasResults":12,"nctId":304,"briefTitle":305,"officialTitle":306,"acronym":4,"eligibilityCriteria":307,"healthyVolunteers":12,"sex":308,"minAge":20,"maxAge":285,"enrollmentInfo":309,"targetDuration":4,"studyType":311,"phases":4,"briefSummary":312,"conditions":313,"keywords":315,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":320,"lastUpdatePostDateStruct":321,"startDateStruct":323,"completionDateStruct":325,"leadSponsor":327,"locationsCount":50},"100633638","evaluating-traditional-medicine-syndromes-in-male-infertility-with-oligoasthenoteratozoospermia-100633638","NCT07529288","Evaluating Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia","Characterization of Traditional Medicine Syndromes in Male Infertility With Oligoasthenoteratozoospermia Via Latent Tree Models","Inclusion Criteria:\n\n* Male patients aged between 18 and 60 years.\n* Diagnosed with male infertility by an andrology specialist according to World Health Organization (WHO) standards.\n* Semen analysis results meet the diagnostic criteria for Oligoasthenoteratozoospermia (OAT) syndrome.\n* Voluntary agreement to participate in the research and signed Informed Consent Form.\n\nExclusion Criteria:\n\n* Infertility caused by genetic or chromosomal abnormalities, including but not limited to: Klinefelter syndrome, Sandberg mosaic syndrome (46 XY\u002F47 XXY), or XYY syndrome.\n* Presence of structural abnormalities of the reproductive organs.\n* Patients with Azoospermia (absence of sperm in the ejaculate) as defined by WHO 2021 standards.\n* Use of medications affecting spermatogenesis within the last 3 months, including: cannabinoids, hydantoins, valproate, anabolic steroids, cimetidine, colchicine, spironolactone, nitrofurantoin, sulfasalazine, or calcium channel blockers.\n* Inability to understand or answer survey questions due to physical or mental limitations (e.g., mutism, deafness, intellectual disability, coma, or being on a ventilator in the ICU).\n* Lack of cooperation during the clinical examination and interview process.","MALE",{"count":310,"type":24},300,"OBSERVATIONAL","The goal of this observational study is to identify and evaluate the characteristics of Traditional Medicine (TM) syndromes in men aged 18 to 60 with male infertility and oligoasthenoteratozoospermia (OAT) syndrome. The main questions it aims to answer are:\n\n* What are the common Traditional Medicine syndromes and symptoms associated with male infertility based on Traditional Medicine literature?\n* What are the specific Traditional Medicine syndromes and symptoms found in men with OAT syndrome at Binh Dan Hospital when analyzed using Latent Tree Models?\n\nThe research will be conducted in two phases:\n\n* Phase 1 (Literature Review): Researchers will collect and analyze Traditional Medicine texts to list the symptoms and syndromes related to male infertility. This phase will help create a standardized clinical survey.\n* Phase 2 (Clinical Survey): Researchers will recruit 300 male participants with OAT syndrome.\n\n  * Participants will answer a survey questionnaire about their Traditional Medicine symptoms.\n  * Researchers will apply Latent Tree Models (a mathematical approach) to the collected data to objectively classify the TM syndromes.",[314],"Male Infertility With OAT",[316,317,318,319],"Traditional Medicine Pattern","OAT","Male Infertility","Oligoasthenoteratozoospermia","2026-04-09",{"date":322,"type":42},"2026-04-14",{"date":324,"type":42},"2026-01-14",{"date":326,"type":24},"2026-09-30",{"name":48,"class":49},{"id":329,"slug":330,"hasResults":12,"nctId":331,"briefTitle":332,"officialTitle":333,"acronym":4,"eligibilityCriteria":334,"healthyVolunteers":12,"sex":19,"minAge":134,"maxAge":164,"enrollmentInfo":335,"targetDuration":4,"studyType":25,"phases":337,"briefSummary":338,"conditions":339,"keywords":341,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":343,"lastUpdatePostDateStruct":344,"startDateStruct":346,"completionDateStruct":348,"leadSponsor":350,"locationsCount":50},"100633696","efficacy-of-electroacupuncture-combined-with-auricular-acupressure-for-chronic-low-back-pain-100633696","NCT07530042","Efficacy of Electroacupuncture Combined With Auricular Acupressure for Chronic Low Back Pain.","Efficacy of Electroacupuncture Combined With Auricular Acupressure in Patients With Chronic Low Back Pain Due to Lumbar Spondylosis With Kidney Yin Deficiency Syndrome: A Randomized Controlled Trial.","Inclusion Criteria:\n\n* Age between 40 and 70 years.\n* Low back pain persisting for ≥ 12 weeks.\n* Pain intensity: 30 ≤ VAS ≤ 70.\n* Disability index: ODI ≥ 10%.\n* Diagnosed with Lumbar Spondylosis by a physician, supported by clinical signs (mechanical pain) and imaging (X-ray or MRI showing degeneration).\n* Diagnosed with Kidney Yin deficiency syndrome by a certified TCM physician, exhibiting symptoms such as: lower back\u002Fknee soreness, afternoon fever\u002Fhot flashes, night sweats, tinnitus, dry mouth, red tongue, or rapid\u002Ffine pulse.\n* Voluntary consent to participate.\n\nExclusion Criteria:\n\n* Contraindications to auricular acupressure (e.g., ear skin infection) or electroacupuncture (e.g., pregnancy, severe heart failure, surgical indications, pacemakers, metal implants).\n* Specific causes of low back pain (e.g., infection, tumor, osteoporosis, ankylosing spondylitis, fracture).\n* Disc herniation with surgical indications (e.g., muscle atrophy, severe limb weakness, or sphincter dysfunction).\n* Currently participating in other interventional studies.\n* Currently taking medications that may affect study outcomes (painkillers, muscle relaxants, antidepressants, TCM drugs).",{"count":336,"type":24},76,[27],"Chronic low back pain (CLBP) due to lumbar spondylosis is a leading cause of disability, significantly impacting the quality of life in middle-aged and elderly populations. While electroacupuncture (EA) and auricular acupressure (AA) are recognized as safe, non-pharmacological therapies, high-quality clinical evidence specifically evaluating their combined effects on CLBP patients with TCM \"Kidney Yin deficiency\" syndrome remains limited.This randomized controlled trial aims to evaluate the efficacy and safety of combining EA with AA (utilizing Vaccaria segetalis seeds) compared to EA combined with sham AA. The study will focus on 76 eligible patients at Le Van Thinh Hospital. Primary objectives are to measure changes in pain intensity (VAS) and functional improvement (ODI) at three intervals: baseline (T0), after 7 days (T1), and upon completion of the 14-day intervention (T2). The findings are expected to provide an evidence-based foundation for an integrated treatment approach to manage chronic lumbar pain effectively.",[340,112],"Chronic Low Back Pain (CLBP)",[33,188,342],"Kidney Yin Deficiency","2026-04-08",{"date":345,"type":42},"2026-04-15",{"date":347,"type":24},"2026-04-20",{"date":349,"type":24},"2026-12-31",{"name":48,"class":49},{"id":352,"slug":353,"hasResults":12,"nctId":354,"briefTitle":355,"officialTitle":356,"acronym":4,"eligibilityCriteria":357,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":358,"targetDuration":4,"studyType":25,"phases":359,"briefSummary":360,"conditions":361,"keywords":363,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":366,"lastUpdatePostDateStruct":367,"startDateStruct":368,"completionDateStruct":370,"leadSponsor":372,"locationsCount":50},"100632929","xuong-tan-lac-than-exercise-for-range-of-motion-and-muscle-endurance-100632929","NCT07520071","\"Xuong Tan Lac Than\" Exercise for Range of Motion and Muscle Endurance","Assessment of Changes in Range of Motion and Muscle Endurance After Practicing the \"Xuong Tan Lac Than\" Exercise in Healthy Volunteers","INCLUSION CRITERIA\n\n* Aged 18 years or older\n* Voluntarily agree to participate in the study\n* Vital signs within normal limits,\n\nEXCLUSION CRITERIA\n\n* Participants with concomitant internal or surgical medical conditions\n* Refusal to participate in the study at any time\n* Inability to perform or complete the assessment procedures\n* Engaging in vigorous physical activity within 2 days prior to the study participation",{"count":5,"type":24},[27],"The goal of this clinical trial is to learn the effects of the \"Xuong tan lac than\" exercise on range of motion and muscle endurance in healthy volunteers. The main questions it aims to answer are:\n\n* Does practicing the \"Xuong tan lac than\" exercise improve joint range of motion (cervical spine, lumbar spine, shoulder, elbow, wrist, knee, and ankle)?\n* Does the exercise improve muscle endurance around these joints?\n\nParticipants will:\n\n* Perform the \"Xuong tan lac than\" exercise for 12 weeks (5 days per week, once daily).\n* Be trained to perform the exercise correctly before starting the intervention.\n* Undergo assessments of joint range of motion and muscle endurance at baseline and after 2, 4, 8, and 12 weeks.",[31,362],"Physical Fitness",[364,365],"Traditional Vietnamese exercise","Xuong tan lac than","2026-04-06",{"date":320,"type":42},{"date":369,"type":42},"2026-01-15",{"date":371,"type":24},"2026-09-01",{"name":48,"class":49},{"id":374,"slug":375,"hasResults":12,"nctId":376,"briefTitle":377,"officialTitle":378,"acronym":4,"eligibilityCriteria":379,"healthyVolunteers":12,"sex":19,"minAge":380,"maxAge":381,"enrollmentInfo":382,"targetDuration":4,"studyType":25,"phases":384,"briefSummary":385,"conditions":386,"keywords":389,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":400,"completionDateStruct":402,"leadSponsor":404,"locationsCount":50},"100631487","recombinant-tropomyosin--and-hemocyanin-specific-ige-in-children-with-suspected-shrimp-allergy-100631487","NCT07501325","Recombinant Tropomyosin- and Hemocyanin-Specific IgE in Children With Suspected Shrimp Allergy","Diagnostic Value of Recombinant Tropomyosin- and Hemocyanin-Specific IgE for the Diagnosis of IgE-Mediated Shrimp Allergy in Children in Vietnam","Inclusion Criteria:\n\n* Children aged 1 to 16 years.\n* Evaluated at the Allergy Unit of Children's Hospital 1.\n* Clinical history suggestive of IgE-mediated shrimp allergy based on EAACI 2023 criteria, including at least 1 typical allergic symptom (urticaria, angioedema, vomiting, abdominal pain, diarrhea, cough, wheezing, dyspnea, or hypotension), symptom onset within 2 hours after shrimp ingestion, and recurrence on at least 2 separate exposures.\n* Parent or legal guardian able to provide written informed consent; child assent obtained when appropriate.\n\nExclusion Criteria:\n\n* Acute illness at the time of enrollment or challenge, including acute respiratory infection, acute gastrointestinal infection, or acute asthma exacerbation.\n* Severe chronic disease, including malignancy, severe liver or kidney disease, primary immunodeficiency, or significant heart disease affecting hemodynamic status.\n* Mental or behavioral disorder that prevents completion of study procedures.\n* Use of immunosuppressive medication (oral corticosteroids, cytotoxic drugs, or biologic agents) within 4 weeks before enrollment, or intravenous immunoglobulin within the previous 3 months.\n\nExclusion Criteria:\n\n* Acute illness at the time of enrollment or challenge, including acute respiratory infection, acute gastrointestinal infection, or acute asthma exacerbation; participants may be rescheduled after recovery.\n* Severe chronic disease, including malignancy, severe liver or kidney disease, primary immunodeficiency, or significant heart disease affecting hemodynamic status.\n* Mental or behavioral disorder that prevents completion of study procedures.\n* Use of immunosuppressive medication (oral corticosteroids, cytotoxic drugs, or biologic agents) within 4 weeks before enrollment, or intravenous immunoglobulin within the previous 3 months.","1 Year","16 Years",{"count":383,"type":24},129,[27],"This study will evaluate whether blood tests that measure IgE antibodies to two shrimp proteins, tropomyosin and hemocyanin, can help diagnose shrimp allergy in children. Children with suspected IgE-mediated shrimp allergy will undergo oral food challenge, skin prick testing, and blood sampling. Oral food challenge results will be used as the reference standard to determine whether these tests can accurately identify true shrimp allergy and help improve diagnosis in clinical practice.",[387,388],"Food Hypersensitivity","Shellfish Allergy",[390,391,392,393,394,395,388,396,387,397],"Oral Food Challenge","Skin Prick Test","Tropomyosin","Hemocyanin","Specific IgE","Recombinant Allergen","Children","Shrimp Allergy","2026-03-31",{"date":366,"type":42},{"date":401,"type":24},"2026-04",{"date":403,"type":24},"2028-04",{"name":48,"class":49},{"id":406,"slug":407,"hasResults":12,"nctId":408,"briefTitle":409,"officialTitle":410,"acronym":4,"eligibilityCriteria":411,"healthyVolunteers":12,"sex":308,"minAge":20,"maxAge":4,"enrollmentInfo":412,"targetDuration":414,"studyType":311,"phases":4,"briefSummary":415,"conditions":416,"keywords":418,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":420,"lastUpdatePostDateStruct":421,"startDateStruct":423,"completionDateStruct":424,"leadSponsor":426,"locationsCount":50},"100630400","a-survey-of-traditional-medicine-pattern-identification-in-patients-with-erectile-dysfunction-100630400","NCT07487181","A Survey of Traditional Medicine Pattern Identification in Patients With Erectile Dysfunction","Traditional Medicine Pattern Distribution in Patients With Erectile Dysfunction: A Cross-sectional Study","Inclusion Criteria:\n\n* Individuals aged 18 years or older who were diagnosed with erectile dysfunction by a clinical physician at Binh Dan Hospital between January 2026 and August 2026.\n* Willing to participate in the study and provide informed consent.\n\nExclusion Criteria:\n\n* Unable to understand the questionnaire.\n* Unable to complete all the study questions.\n* Patients who do not wish to continue participating in the study.",{"count":413,"type":24},375,"1 Day","Erectile dysfunction (ED) is a common condition that significantly affects quality of life, psychological well-being, and interpersonal relationships. In Traditional Medicine, ED is classified into different syndrome patterns, which are essential for guiding individualized treatment; however, evidence on their distribution and associated factors in Vietnam remains limited. This cross-sectional study aims to determine the distribution of Traditional Medicine syndrome patterns in patients with ED and to evaluate their associations with demographic characteristics, clinical features, psychological status, and lifestyle factors, thereby providing evidence to support improved diagnosis and integrative treatment approaches.",[417],"Erectile Dysfunctions",[316,417,419],"IIEF-5","2026-03-17",{"date":422,"type":42},"2026-03-23",{"date":324,"type":42},{"date":425,"type":24},"2026-08-31",{"name":48,"class":49},{"id":428,"slug":429,"hasResults":12,"nctId":430,"briefTitle":431,"officialTitle":432,"acronym":433,"eligibilityCriteria":434,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":435,"targetDuration":4,"studyType":25,"phases":437,"briefSummary":438,"conditions":439,"keywords":442,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":448,"lastUpdatePostDateStruct":449,"startDateStruct":451,"completionDateStruct":453,"leadSponsor":455,"locationsCount":50},"100628318","immediate-implant-placement-with-autogenous-maxillary-tuberosity-graft-in-the-esthetic-zone-100628318","NCT07460076","Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone","Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series","TUBERO-IMPLANT","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients requiring single implant placement in the maxillary esthetic zone\n* Indication for immediate implant placement following tooth extraction\n* Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft\n* Adequate oral hygiene and ability to maintain postoperative care\n* Willingness to participate in the study and provide informed consent\n\nExclusion Criteria:\n\n* Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases\n* History of radiotherapy in the head and neck region\n* Active periodontal disease or untreated oral infection\n* Heavy smoking (more than 10 cigarettes per day)\n* Pregnancy or lactation\n* Severe parafunctional habits\n* Insufficient bone volume preventing implant placement with the planned protocol\n* Patients unable to attend follow-up visits",{"count":436,"type":24},15,[27],"Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.\n\nThis prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.",[440,441],"Alveolar Bone Loss","Esthetic Zone Implant Rehabilitation",[443,444,445,446,447],"Immediate Implant Placement","Maxillary Tuberosity Graft","Autogenous Bone Graft","Dental Implant","Pink Esthetic Score","2026-03-04",{"date":450,"type":42},"2026-03-10",{"date":452,"type":42},"2026-01-01",{"date":454,"type":24},"2026-11",{"name":48,"class":49},{"id":457,"slug":458,"hasResults":12,"nctId":459,"briefTitle":460,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":463,"targetDuration":4,"studyType":25,"phases":465,"briefSummary":466,"conditions":467,"keywords":469,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":479,"lastUpdatePostDateStruct":480,"startDateStruct":482,"completionDateStruct":484,"leadSponsor":486,"locationsCount":4},"100627214","cyanoacrylate-adhesive-in-impacted-mandibular-third-molars-surgery-100627214","NCT07445724","Cyanoacrylate Adhesive in Impacted Mandibular Third Molars Surgery","Evaluation of Soft Tissue Healing and Microbiological Status in Patients Undergoing Surgical Extraction of Impacted Mandibular Third Molars Using Cyanoacrylate Adhesive","Inclusion Criteria:\n\n* Patients aged 18 years or older.\n* Patients presenting with bilateral mandibular third molars indicated for extraction, with the same level of surgical difficulty according to the Pell-Gregory classification, and an angulation difference between the two teeth not exceeding 15° according to the Winter classification on panoramic radiographs.\n* No use of local or systemic antibiotics within 2 weeks prior to surgery.\n* Absence of serious systemic diseases such as coagulation disorders or uncontrolled diabetes, and no acute infection at the extraction site.\n* Patients who agree to participate in the study after receiving clear explanation and counseling.\n\nExclusion Criteria:\n\n* Patients who are uncooperative in providing necessary information or who decline to continue participation in the study.\n* A difference in surgical duration between the two sides exceeding 12 minutes, or the occurrence of intraoperative complications.\n* Patients with known hypersensitivity or allergy to any materials used in the study, such as lidocaine local anesthetic, cyanoacrylate adhesive, or suture materials.",{"count":464,"type":24},23,[27],"The goal of this randomized clinical trial is to evaluate whether cyanoacrylate tissue adhesive can improve postoperative outcomes compared with conventional silk sutures in patients undergoing surgical removal of impacted mandibular third molars.\n\nThe main questions it aims to answer is: Is there a difference in wound healing support, soft-tissue conditions, and microbiological outcomes at the surgical site of impacted mandibular third molar extraction between closure with conventional sutures and cyanoacrylate tissue adhesive? Researchers will compare cyanoacrylate tissue adhesive with conventional silk sutures to determine whether the adhesive provides superior postoperative recovery and periodontal outcomes.\n\nParticipants will:\n\n* Undergo surgical extraction of an impacted mandibular third molar.\n* Receive wound closure using either cyanoacrylate tissue adhesive or conventional silk sutures.\n* Be followed postoperatively for assessment of pain, swelling, trismus, soft-tissue healing, and periodontal measurements at specified time points.",[468],"Impacted Mandibular Third Molar",[470,471,472,473,217,474,475,476,477,478],"impacted mandibular third molar","Cyanoacrylate tissue adhesive","Silk suture","Wound closure","Soft-tissue healing","Periodontal healing","Oral microbiota","Randomized controlled trial","Oral surgery","2026-02-25",{"date":481,"type":42},"2026-03-03",{"date":483,"type":24},"2026-03",{"date":485,"type":24},"2026-12",{"name":48,"class":49},{"id":488,"slug":489,"hasResults":12,"nctId":490,"briefTitle":491,"officialTitle":492,"acronym":4,"eligibilityCriteria":493,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":494,"enrollmentInfo":495,"targetDuration":4,"studyType":25,"phases":497,"briefSummary":498,"conditions":499,"keywords":501,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":509,"lastUpdatePostDateStruct":510,"startDateStruct":512,"completionDateStruct":514,"leadSponsor":515,"locationsCount":50},"100622649","wound-healing-and-bacterial-adherence-with-triclosan-coated-sutures-after-mandibular-impacted-third-molar-surgery-100622649","NCT07386366","Wound Healing and Bacterial Adherence With Triclosan-Coated Sutures After Mandibular Impacted Third Molar Surgery","Evaluation of Soft Tissue Healing and Antibacterial Effectiveness of Triclosan-Coated Polyglactin 910 Sutures After Impacted Mandibular Third Molar Surgery: A Randomized Double-Blind Split-Mouth Clinical Trial","Inclusion Criteria:\n\n* Adults aged 18 to 35 years.\n* American Society of Anesthesiologists (ASA) physical status I or II.\n* Presence of two symmetric impacted mandibular third molars with the same level of difficulty according to the Pell-Gregory and Winter classification; the difference in angulation between the two third molars is no more than 15 degrees.\n* No use of topical or systemic antibiotics for at least 4 weeks before surgery.\n* Able and willing to provide written informed consent.\n* No active infection associated with the mandibular third molar at the time of enrollment.\n\nExclusion Criteria:\n\n* Pregnant or breastfeeding.\n* Allergy to local anesthetic (2% lidocaine with 1:100,000 epinephrine) or any medications used in the study.\n* Radiographic findings suggestive of a tumor or cyst associated with the impacted mandibular third molar.\n* Participant withdraws consent or does not agree to continue participation.\n* Unable to attend scheduled follow-up visits.\n* Difference in surgical extraction time between the two procedures is 12 minutes or more.\n* Suture loss\u002Floosening before completion of the final assessment time point.","35 Years",{"count":496,"type":24},14,[27],"The goal of this clinical trial is to learn if triclosan-coated absorbable stitches (polyglactin 910 sutures coated with triclosan, an antibacterial agent) help soft tissue heal better and have fewer bacteria stuck to the stitches after lower impacted wisdom tooth surgery in adults aged 18 to 35 years.\n\nThe main questions it aims to answer are:\n\n1. Does triclosan-coated polyglactin 910 suture lead to better soft-tissue wound healing than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n2. Does triclosan-coated polyglactin 910 suture result in a lower oral bacterial load adhered to the suture material than non-coated polyglactin 910 suture on postoperative days 3, 5, and 7 after mandibular impacted third molar surgery?\n\nParticipants will:\n\n* Have surgery to remove two similar lower impacted wisdom teeth (one on each side)\n* Receive triclosan-coated stitches on one side and standard stitches on the other side, with the side assignment chosen at random\n* Return for follow-up visits on day three, day five, and day seven after surgery for healing checks, simple ratings of pain and swelling, and collection of a small stitch sample for bacterial testing.",[468,500],"Postoperative Wound Healing",[502,503,504,505,478,506,507,508],"Triclosan-coated suture","Polyglactin 910","Impacted third molar surgery","Mandibular third molar","Postoperative wound healing","Bacterial adhesion","Antibacterial suture","2026-01-27",{"date":511,"type":42},"2026-02-04",{"date":513,"type":42},"2025-10-07",{"date":194,"type":24},{"name":48,"class":49},{"id":517,"slug":518,"hasResults":12,"nctId":519,"briefTitle":520,"officialTitle":520,"acronym":4,"eligibilityCriteria":521,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":522,"targetDuration":4,"studyType":25,"phases":524,"briefSummary":525,"conditions":526,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":530,"lastUpdatePostDateStruct":531,"startDateStruct":533,"completionDateStruct":535,"leadSponsor":537,"locationsCount":50},"100607622","effects-of-low-level-laser-therapy-on-soft-and-hard-tissue-healing-after-impacted-mandibular-third-molar-extraction-100607622","NCT07190950","Effects of Low-level Laser Therapy on Soft and Hard Tissue Healing After Impacted Mandibular Third Molar Extraction","Inclusion Criteria:\n\n* Healthy patients (at least 18 years of age) have both jaws lower impacted third molars indicated to be extracted. Both teeth are the same of\n\nExclusion Criteria:\n\n\\-",{"count":523,"type":24},22,[27],"Impacted lower third molar extraction is one of the most commonly performed dental procedures in daily practice. However, this is considered a relatively invasive procedure. During the surgery, dental surgeon must reflect a full-thickness flap, remove bone to expose the tooth, section and deliver the tooth. As a result, after surgery, patients often experience many complications, from swelling, pain, jaw tightness, etc. to alveolar bone loss, periodontal problems distal to the second molar, etc.\n\nTherefore, clinicians are always looking for additional therapies to minimize complications, helping patients have a more comfortable experience after wisdom tooth surgery.\n\nTo date, placing grafting materials such as bone or other biological materials (growth factors, platelet-rich plasma, platelet-rich fibrin) into the tooth socket has been shown to be able to preserve the alveolar crest after extraction. However, these materials require preparation time, are costly, and have the risk of infection related to bone grafts.\n\nMeanwhile, low-level laser therapy (LLLT) is known as a safe, non-invasive therapy that can affect cell metabolism without causing tissue damage. This therapy has been widely applied in many fields of medicine in general and in dentistry in particular. Low-level lasers have been studied to help reduce swelling, pain, and jaw tightness after impacted lower wisdom teeth surgery. In vitro or in vivo studies evaluating the healing effect of low-level lasers have given very positive results. However, there is still a lack of scientific evidence to prove the healing effect of low-level lasers on human tooth extraction sockets.\n\nThe study we conducted is a scientific study, in the field of Dentistry. This study aimed to evaluate the effectiveness of low-level laser on soft tissue and bone healing after surgical extraction of impacted lower third molars in a group of Vietnamese population.",[527,528,529],"Third Molars Extraction","Low Level Laser Therapy","Bone Healing","2025-11-26",{"date":532,"type":42},"2025-11-28",{"date":534,"type":42},"2024-08-30",{"date":536,"type":24},"2025-12-31",{"name":48,"class":49},{"id":539,"slug":540,"hasResults":12,"nctId":541,"briefTitle":542,"officialTitle":542,"acronym":4,"eligibilityCriteria":543,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":544,"targetDuration":4,"studyType":25,"phases":546,"briefSummary":547,"conditions":548,"keywords":553,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":557,"lastUpdatePostDateStruct":558,"startDateStruct":560,"completionDateStruct":562,"leadSponsor":564,"locationsCount":50},"100607725","using-platelet-rich-fibrin-in-regenerative-endodontic-treatment-in-mature-permanent-teeth-100607725","NCT07192289","Using Platelet-rich Fibrin in Regenerative Endodontic Treatment in Mature Permanent Teeth","Inclusion Criteria:\n\nParticipants had a single-rooted tooth with necrotic pulp (negative response to electric pulp testing), with or without periapical pathology (acute apical periodontitis of pulpal origin, chronic periapical periodontitis, periapical abscess with sinus, periapical abscess without sinus), and gave their consent to participate in the study.\n\nExclusion Criteria: Study samples will be excluded if any of the following criteria are met:\n\n* The tooth has had previous endodontic treatment.\n* The root apex is not fully developed, or there is root resorption\u002Fcracking\u002Ffracture.\n* The tooth has severe tooth loss and is indicated for extraction, or is indicated for restoration with a post or cast core after endodontic treatment.\n* The root canal is calcified.\n* The root canal curvature is greater than 25º.\n* The tooth has a periapical cyst or is associated with a jawbone cyst.\n* The tooth has a periodontal pocket deeper than 4 mm.\n* The tooth has no occlusal contact.\n* The patient is pregnant.\n* The patient has diabetes or HIV or other immunocompromised conditions.",{"count":545,"type":24},57,[27],"This study aims to evaluate the antibacterial effects of injectable platelet-rich fibrin (i-PRF) in vitro, and to assess the clinical and radiographic outcomes of using advanced platelet-rich fibrin (A-PRF+) and i-PRF in regenerative endodontic treatment of mature permanent teeth with necrotic pulp. The study will compare the effectiveness of PRF-based treatment with conventional blood clot-based regenerative endodontics.",[549,550,551,552],"Chronic Apical Periodontitis","Necrosis of Pulp","Acute Apical Periodontitis of Pulpal Origin","Periapical Abscess",[554,555,556],"PRF","regenerative endodontic treatment","mature permanent treatment","2025-09-21",{"date":559,"type":42},"2025-09-25",{"date":561,"type":24},"2025-09-15",{"date":563,"type":24},"2027-08-31",{"name":48,"class":49},{"id":566,"slug":567,"hasResults":12,"nctId":568,"briefTitle":569,"officialTitle":570,"acronym":4,"eligibilityCriteria":571,"healthyVolunteers":12,"sex":19,"minAge":134,"maxAge":4,"enrollmentInfo":572,"targetDuration":4,"studyType":25,"phases":574,"briefSummary":575,"conditions":576,"keywords":578,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":589,"leadSponsor":591,"locationsCount":50},"100589264","comparison-of-phaco-surgery-with-goniosynechialysis-versus-trabeculectomy-in-glaucoma-treatment-100589264","NCT06952153","Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment","Comparison of Phaco Surgery and Goniosynechialysis Versus Trabeculectomy Outcomes in Glaucoma Patients","Inclusion Criteria:\n\n* Age ≥ 40 years\n* Peripheral anterior synechiae (PAS) \\>180°\n* Glaucomatous optic neuropathy with visual field loss\n* Intraocular pressure (IOP) \\> 21 mmHg despite medication\n* Ability to consent and comply with follow-up\n* Cataract grade 1 to 3 according to LOCS III\n* Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20\u002F40 Snellen or worse)\n\nExclusion Criteria:\n\n* Very advanced glaucoma (only light perception vision)\n* Secondary angle-closure etiologies\n* Prior ocular surgeries or laser peripheral iridotomy (PI)\n* Allergy to 5-fluorouracil (5-FU), if used postoperatively\n* Irreversible corneal disease\n* Chronic corticosteroid use\n* Poor follow-up compliance\n* Cataract grade 4 or 5 (LOCS III)\n* Phacomorphic, phacolytic, or subluxated cataracts",{"count":573,"type":24},82,[27],"The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma.\n\nThe main questions it aims to answer are:\n\n* Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy?\n* What are the rates of postoperative complications or adverse events between the two surgical approaches?\n* How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications?\n\nResearchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma.\n\nParticipants will:\n\nBe randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks",[577],"Primary Angle Closure Glaucoma",[579,580,581,582,583],"PACG","Phaco-GSL","trabeculectomy","RCT","Ophthalmic surgery","2025-09-04",{"date":586,"type":42},"2025-09-11",{"date":588,"type":42},"2025-06-01",{"date":590,"type":24},"2027-09-10",{"name":48,"class":49},{"id":593,"slug":594,"hasResults":12,"nctId":595,"briefTitle":596,"officialTitle":597,"acronym":4,"eligibilityCriteria":598,"healthyVolunteers":12,"sex":19,"minAge":599,"maxAge":4,"enrollmentInfo":600,"targetDuration":4,"studyType":25,"phases":602,"briefSummary":603,"conditions":604,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":606,"lastUpdatePostDateStruct":607,"startDateStruct":609,"completionDateStruct":611,"leadSponsor":613,"locationsCount":50},"100601748","effect-of-collagen-membranes-on-distal-periodontal-healing-of-second-molars-after-impacted-mandibular-third-molar-surgery-100601748","NCT07114523","Effect of Collagen Membranes on Distal Periodontal Healing of Second Molars After Impacted Mandibular Third Molar Surgery.","Effect of Collagen Membranes on Distal Periodontal Healing of Second Molars After Impacted Mandibular Third Molar Surgery: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Patients aged 25 years or older.\n* Patients with mesioangular or horizontally impacted mandibular third molars. The highest point of mandibular third molars are lower than the occlusal surface of adjacent second molars (classified B, C according to Pell - Gregory's category).\n* Patients with symmetrical lower third molars on both sides with same classification according to Pell - Gregory's category. The difference of third molars inclination on both side is not more than 15°.\n* Patients with lower second molars on both sides have no cavities or fillings that affect the determination of the cemento-enamel junction.\n* Patients are explained, counseled clearly and sign their consent to participate in the study.\n\nExclusion Criteria:\n\n* Patients with coagulation or immune disorders.\n* Patients allergic to local anesthetics (Lidocaine 2% with Adrenaline 1:100,000) or any drugs used in the study.\n* Patients allergic to products or food derived from pigs.\n* Pregnant or breastfeeding patients.\n* Patients who smoke.\n* Patients with systemic conditions that contraindicate surgical procedures.\n* Patients with clinical or radiographic signs suggestive of tumors (benign or malignant) associated with or in proximity to the mandibular third molar.\n* Patients with missing mandibular second molars.","25 Years",{"count":601,"type":24},20,[27],"Impacted mandibular third molars can cause various complications to the adjacent second molars, such as dental caries, periodontitis, or root resorption. These complications often progress silently and asymptomatically. A typical scenario involves a mesioangularly impacted third molar exerting pressure on the distal alveolar bone of the second molar, resulting in persistent food impaction that is difficult for patients to clean. Furthermore, the surgical removal of deeply impacted or severely angulated mandibular third molars often requires bone removal in the area adjacent to the second molar. These factors may exacerbate distal periodontal defects of the second molar, especially in individuals over the age of 25. This research focuses on evaluating the effectiveness of a new-generation collagen membrane in promoting healing after the extraction of impacted mandibular third molars in patients at risk of distal periodontal tissue damage to the second molars",[605],"Periodontal Defect","2025-08-06",{"date":608,"type":42},"2025-08-11",{"date":610,"type":42},"2024-12-01",{"date":612,"type":24},"2027-03-31",{"name":48,"class":49},{"id":615,"slug":616,"hasResults":12,"nctId":617,"briefTitle":618,"officialTitle":619,"acronym":4,"eligibilityCriteria":620,"healthyVolunteers":12,"sex":19,"minAge":621,"maxAge":285,"enrollmentInfo":622,"targetDuration":4,"studyType":25,"phases":623,"briefSummary":624,"conditions":625,"keywords":626,"overallStatus":68,"whyStopped":4,"lastUpdateSubmitDate":629,"lastUpdatePostDateStruct":630,"startDateStruct":632,"completionDateStruct":633,"leadSponsor":635,"locationsCount":4},"100584732","cupping-therapy-for-neck-pain-in-cervical-spondylosis-100584732","NCT06893185","Cupping Therapy for Neck Pain in Cervical Spondylosis","Effectiveness of Cupping Therapy in Managing Neck Pain and Improving Cervical Mobility in Cervical Spondylosis Patients: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Individuals between the ages of 20 and 60 years, outpatient treatment.\n* Individuals diagnosed with cervical spondylosis.\n* Individuals report pain intensity between 3 and 8 according to on the Visual Analogue Scale (VAS) on the screening visit day.\n* Experiencing neck pain for no longer than four weeks.\n* Individuals who volunteered to participate in the study and signed a consent form.\n\nExclusion Criteria:\n\n* Patients diagnosed with acute or chronic neck pain due to specific causes or with root compression syndrome, spinal cord compression syndrome, or vertebral artery syndrome.\n* Patients loss of normal cervical curvature or deformity.\n* Individuals with a history of neck trauma, cervical vertebra fracture, or cervical spine surgery, congenital spinal abnormalities, systemic bone and joint diseases.\n* Patients have undergone cupping therapy, plastering, or drug inhalation within one week prior to participating in the study.\n* Patients used of medications that could affect research outcomes within one week: Pain relievers, muscle relaxants, traditional medicines for treating neck pain.\n* Patients suffer from a mental illness or lacks consciousness.\n* Patients have a pacemaker, or any metal devices such as screws or plates.\n* Patients currently using anticoagulant medications or has a bleeding disorder.","20 Years",{"count":573,"type":24},[27],"Cervical spondylosis is one of the common causes of chronic neck pain. It can significantly affect the quality of life, lead to disabilities, and increase the economic burden on patients. Treatment mainly includes pain relievers, non-steroidal anti-inflammatory drugs (NSAIDs), muscle relaxants or physical therapy. The condition tends to recur frequently; therefore, long-term use of medication can lead to unwanted effects on the digestive system, kidneys, and cardiovascular system.\n\nDry cupping therapy is a non-pharmacological method that has been shown to be effective in pain management. Cupping therapy has the advantage of being applicable to patients who are afraid of needles and has a wide area of effect.\n\nGiven the limitations in evaluating treatment effectiveness and safety, along with the lack of published research discussing the analgesic effects of dry cupping for neck pain caused by cervical spondylosis, the investigators conducted the study on pain reduction and safety of cupping therapy in patients with neck pain caused by cervical spondylosis.",[66,64],[66,627,628],"Cupping therapy","Cervical spondylosis","2025-05-23",{"date":631,"type":42},"2025-05-29",{"date":588,"type":24},{"date":634,"type":24},"2025-08-31",{"name":48,"class":49},{"id":637,"slug":638,"hasResults":12,"nctId":639,"briefTitle":640,"officialTitle":641,"acronym":4,"eligibilityCriteria":642,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":643,"targetDuration":4,"studyType":25,"phases":644,"briefSummary":645,"conditions":646,"keywords":649,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":654,"lastUpdatePostDateStruct":655,"startDateStruct":657,"completionDateStruct":659,"leadSponsor":661,"locationsCount":50},"100590963","morphological-characteristics-of-anterior-maxillary-bone-and-dynamic-navigation-in-full-arch-implant-placement-100590963","NCT06974253","Morphological Characteristics of Anterior Maxillary Bone and Dynamic Navigation in Full-Arch Implant Placement","Morphological Characteristics of Anterior Maxillary Anchorage Sites and Application of Dynamic Navigation in Full-Arch Dental Implant Placement","Inclusion Criteria:\n\n* Aged 18 years or older\n* Good overall health (Class 1 and 2 according to the American Society of Anesthesiologists classification system)\n* Clinical diagnosis of complete edentulism of the upper arch classified as Class IV to VI according to Cawood and Howell\n\nExclusion Criteria:\n\n* Systemic or local conditions that may affect surgery, wound healing, or bone integration, such as cardiovascular diseases, diabetes, bone-related diseases, or medication affecting bone metabolism\n* Smoking more than 10 cigarettes per day\n* Presence of acute infections in the planned implant site\n* Limited mouth opening of less than 40mm",{"count":601,"type":24},[27],"The goal of this clinical trial is to evaluate the effectiveness of dynamic navigation in full-arch dental implant placement in patients with complete maxillary edentulism. The main questions it aims to answer are:\n\n* the accuracy of nasopalatine implants, trans-sinus implants, and trans-nasal implants placement in the anterior maxillary bone with dynamic navigation\n* the clinical effectiveness of nasopalatine implants, trans-sinus implants, and trans-nasal implants in full-arch rehabilitation\n* the correlation between the anatomical features of the nasal cavity and the anterior sinus wall on CBCT images and their influence on nasopalatine implants, trans-sinus implants, and trans-nasal implants position",[647,648],"Atrophy of Edentulous Maxillary Alveolar Ridge","Alveolar Bone Atrophy",[650,651,652,653],"Nasopalatine Implant","Trans-sinus Implant","Trans-nasal Implant","Piriform Rim Implant","2025-05-08",{"date":656,"type":42},"2025-05-15",{"date":658,"type":24},"2025-05-30",{"date":660,"type":24},"2028-02",{"name":48,"class":49},""]