[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Minho\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":213},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,6,0,[8,55,93,126,158,185],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":34,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":43,"lastUpdatePostDateStruct":44,"startDateStruct":47,"completionDateStruct":49,"leadSponsor":51,"locationsCount":54},"100637070","virtual-reality-for-recovery-after-intensive-care-pics-100637070",false,"NCT07585500","Virtual Reality for Recovery After Intensive Care (PICS)","Virtual Reality Intervention for Post-Intensive Care Syndrome (PICS): A Protocol for a Pilot Randomized Controlled Trial for Cognitive, Physical and Psychological Outcomes","VR4ICU","Inclusion Criteria:\n\n* Adult patients, 18 years or older\n* Patients in the Intensive Care Unit\n* Ventilated patients must be in the post-extubation period\n* The patient has a projected remaining hospital stay of at least 4 days (assessed by the clinical team)\n* The patient has RASS score between -1 and +1\n* The patient has the ability to move both arms, even if with difficulties, as assessed by the clinical team, to be able to interact with the software\n* The patient can maintain a stable sitting position (30° to 60°)\n* The patient is able to communicate (speech, gesturing, or writing)\n* The patient can communicate and understand Portuguese\n* The patient or a legal representative provided informed consent\n\nExclusion Criteria:\n\n* Severe cognitive and neurodegenerative diseases: mental illness requiring institutionalization; acquired or congenital intellectual disability; known severe brain injuries (e.g., stroke with significant residual deficits); moderate to severe Traumatic Brain Injury (TBI) (defined by the duration of loss of consciousness\u002Fpost-traumatic amnesia or documented residual deficits); diagnosed neurodegenerative diseases (e.g., Parkinson's disease with severe movement impairment, Huntington's disease, severe Alzheimer's disease, or dementia of any etiology that prevents autonomy in daily life at baseline)\n* The patient uses neuromuscular blocking agents\n* The patient has a positive CAM-ICU result at the time of initial screening\n* The patient has active psychotic disorders or suicidal ideation\n* The patient has documented epilepsy or history of seizures\n* The patient has a \"Do Not Resuscitate\" (DNR) order, is on life support with exclusive focus on comfort, or has an unexpected survival predicted to be less than 24 hours\n* The patient has intoxication by an active substance or withdrawal syndrome requiring ongoing medical management that prevents safe and meaningful participation or accurate cognitive assessment\n* Patients with immobility or severe motor limitations in the upper limbs, fine motor skills, or cervical region\n* The patient has open wounds on the head or face that may affect the comfortable\u002Fsafe use of VR glasses, cause discomfort, or present a hygiene risk\n* The patient has uncorrected blindness or deafness that prevents the safe\u002Feffective use of VR\u002Ftablet devices.\n* Patients are participating in another rehabilitation study with interventions\n* Patients with a scheduled surgery where the ICU stay is expected to be less than 24 hours\n* Patients in need of respiratory support","ALL","18 Years",{"count":20,"type":21},51,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this clinical trial is to learn if virtual reality (VR) helps improve thinking and memory skills in adults who have stayed in the intensive care unit (ICU). The study focuses on people who needed a breathing machine or stayed in the ICU for several days and are at risk for memory or \"brain fog\" issues.\n\nThe main questions it aims to answer are:\n\n* Does using VR improve a participant's memory, attention, and thinking skills after an ICU stay?\n* Does the \"immersive\" feel of a VR headset work better to improve these skills than using a handheld tablet?\n\nResearchers will compare three groups to see how different types of care affect the brain:\n\n* VR-Rehab: Participants use a VR headset to play brain-training games.\n* Tablet-Rehab: Participants use a handheld tablet to play the same brain-training games.\n* Standard Care: Participants receive the usual hospital care without digital brain games.\n\nParticipants will:\n\n* Play brain-training games for 12 minutes every day for up to one week while in the hospital.\n* Complete memory and thinking tests with a researcher at the start of the study and again after two weeks.\n* Answer follow-up questions about their memory and thinking skills for 6 months after leaving the hospital.",[27,28,29,30,31,32,33],"Post-Intensive Care Syndrome (PICS)","Critical Illness Recovery","Rehabilitation After Critical Illness","Rehabilitation Exercise of ICU Patients","Cognitive Impairment","Critical Illness","Intensive Care Unit (ICU)",[27,31,32,35,36,37,33,38,39,40,41],"Virtual Reality (VR)","Digital Health","Rehabilitation","Critical Care","ICU Survivors","Pilot Study","Randomized Controlled Trial","RECRUITING","2026-05-08",{"date":45,"type":46},"2026-05-13","ACTUAL",{"date":48,"type":46},"2025-12-06",{"date":50,"type":21},"2026-06",{"name":52,"class":53},"University of Minho","OTHER",1,{"id":56,"slug":57,"hasResults":11,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":61,"eligibilityCriteria":62,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":63,"targetDuration":4,"studyType":22,"phases":65,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":54},"100620329","between-paws-and-affections---impact-of-dog-assisted-therapy-in-fibromyalgia-patients-100620329","NCT07356206","Between Paws and Affections - Impact of Dog-Assisted Therapy in Fibromyalgia Patients","Between Paws and Affections: Impact of Dog Assisted Therapy on Pain, Emotional Symptoms, and Functioning in Fibromyalgia","IDAT26","Inclusion Criteria:\n\n* Age 18 years or older\n* Confirmed diagnosis of fibromyalgia\n* Being followed at ULS Alto Ave by the Multidisciplinary Pain Unit, Internal Medicine (Auto immune diseases), Physical and Rehabilitation Medicine or Neurology\n* Ability to read and write Portuguese and to understand the study procedures\n* Willingness and ability to participate voluntarily in the 10 session program and all scheduled assessments (T1-T4)\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Allergy to dogs or marked fear of dogs\n* History of aggression towards animals\n* History of oncological disease\n* Concomitant systemic or rheumatologic disease that may confound pain and functional assessment\n* Decompensated psychiatric disorder or severe cognitive impairment that may compromise comprehension of the protocol or adherence to the intervention\n* Refusal to participate or withdrawal of consent at any point",{"count":64,"type":21},60,[24],"The purpose of this study is to evaluate the effectiveness and medium-term maintenance of a structured dog-assisted therapy (DAT) protocol, \"Entre Patas e Afetos\" (Between Paws and Affections), in reducing pain, anxiety and depressive symptoms and in improving functional status and quality of life in Portuguese patients with fibromyalgia (FM) followed at ULS Alto Ave, with systematic outcome assessment in the immediate post intervention phase (T2), 6-month follow-up (T3) and 12-month follow-up (T4).",[68],"Fibromyalgia (FM)",[70,71,72,73,74,75,76,77,78,79,80,81,82,83,84],"Fibromyalgia","Dog-Assisted Therapy","Pain","Anxiety","Depression","Psychoeducation and Relaxation","Fuctional Impact","Catastrophizing","follow-up evaluations","Hospital Anxiety and Depression Scale (HADS)","Pain Catastrophizing Scale","Portuguese Fibromyalgia Impact Questionnaire (FIQ P)","Numerical Rating Scale (NRS)","adapted Wong Baker Faces Pain Scale","Portuguese Brief Pain Inventory - Short Form","2026-04-28",{"date":87,"type":46},"2026-05-05",{"date":89,"type":46},"2026-01-22",{"date":91,"type":21},"2029-06-30",{"name":52,"class":53},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":98,"acronym":4,"eligibilityCriteria":99,"healthyVolunteers":100,"sex":17,"minAge":18,"maxAge":101,"enrollmentInfo":102,"targetDuration":4,"studyType":22,"phases":104,"briefSummary":106,"conditions":107,"keywords":109,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":118,"lastUpdatePostDateStruct":119,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":54},"100511948","phase-2-the-brain-the-bug-and-the-binge-the-interplay-between-binge-drinking-gut-microbiota-and-brain-functioning-100511948","NCT05946083","The Brain, the Bug, and the Binge: the Interplay Between Binge Drinking, Gut Microbiota, and Brain Functioning","The Brain, the Bug, and the Binge: a Double-blind, Randomized Controlled Trial Investigating the Interplay Between Binge Drinking, Gut Microbiota and Brain Functioning","Inclusion Criteria:\n\n* College students whose native language is Portuguese;\n* Age 18-23 years;\n* Binge Drinkers: report (i) drinking 4 (for women)\u002F5 (for men) or more drinks on one occasion at least once a month, (ii) drinking at a speed of at least two drinks per hour during these episodes (which brings blood alcohol concentration to 0.08 g\u002FdL or above), and (iii) having an AUDIT score \\\u003C 20.\n* Non\u002FLow-Drinkers: report (i) never drinking 4\u002F5 or more drinks on one occasion and (ii) having an AUDIT score ≤ 4.\n\nExclusion Criteria:\n\n* Use of illicit drugs as determined by the Drug Use Disorders Identification Test (DUDIT);\n* Alcohol abuse (i.e., AUDIT ≥ 20);\n* Personal history of psychopathological disorders (according to DSM-V criteria);\n* History of traumatic brain injury or neurological disorder;\n* Family history (mother\u002Ffather) of alcoholism diagnosis of substance abuse;\n* Occurrence of one or more episodes of loss of consciousness for more than 30 minutes;\n* Non-corrected sensory deficits;\n* Diagnosis of any gut disease\u002Fproblems or other medical conditions: inflammatory bowel disease, irritable bowel syndrome, Crohn's Disease, celiac disease, lactose intolerance, autoimmune disease;\n* Consumption of medical drugs with psychoactive effects (e.g., antidepressants, anxiolytics or benzodiazepines) during the 4 weeks prior to the experiment;\n* Use of any of the following drugs in the last 4 weeks: laxatives, antibiotics, anticoagulants, non-steroidal anti-inflammatory drugs, analgesics, corticosteroids;\n* No type of metal object implanted in the body, especially in the head (orthodontic appliances are not excluded).",true,"23 Years",{"count":103,"type":21},82,[105],"PHASE2","Adolescence and youth are periods of significant maturational changes which seems to involve greater susceptibility to disruptive events in the brain such as binge drinking (BD). This prevalent pattern of consumption -characterized by repeated alcohol intoxications- is of special concern, as it has been associated with major neurocognitive impairments in the young brain.\n\nRecent studies indicate that alcohol may disrupt the gut microbiota (GM) and that these disruptions may lead to impairments in brain and behavior. Also, interventions with psychobiotics have been shown to result in reductions in alcohol-induced damage and in improvements on cognitive and brain functioning.\n\nThus, the present proposal will explore the effects of BD on GM. Additionally, a GM intervention with psychobiotics both in-vivo and in-vitro, will determine whether improvements in GM composition\u002Ffunction may lead to reductions of alcohol-induced brain damage in BD-population, a barely unexplored research field with major clinical applications.",[108],"Binge Drinking",[110,111,112,108,113,114,115,116,117,41],"Adolescence","Young Adulthood","Alcohol","Gut Microbiome","Microbiota-Gut-Brain Axis","Magnetic Resonance Imaging","Pro-inflammatory cytokines","Psychobiotics","2025-07-10",{"date":120,"type":46},"2025-07-16",{"date":122,"type":46},"2023-02-24",{"date":124,"type":21},"2025-11-30",{"name":52,"class":53},{"id":127,"slug":128,"hasResults":11,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":11,"sex":17,"minAge":134,"maxAge":135,"enrollmentInfo":136,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":138,"conditions":139,"keywords":142,"overallStatus":42,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":54},"100476960","psychological-intervention-for-child-mental-health-based-on-parental-reflective-functioning-to-enhance-positive-parenting-100476960","NCT05490745","Psychological Intervention for Child Mental Health Based on Parental Reflective Functioning to Enhance Positive Parenting","A Psychological Intervention for Children's Mental Health Problems or Disorders Based on Parental Reflective Functioning to Enhance Positive Parenting During Adverse Situations","SK4Parenting+","Inclusion Criteria:\n\n* Age between 3 and 6 years old, inclusive\n* Signaling in the screening (≥16 in the SDQ total scale)\n* CBCL (i.e., ≥60 on the Internalizing and\u002For Externalizing Scale) OR Parents report a high pandemic impact\n* Parental informed consent and commitment to the planned psychological intervention.\n* Parent is the child's legal guardian\n\nExclusion Criteria:\n\n* Already receiving psychological intervention\n* Presence of psychological problems not related to an adverse situation or not likely to be monitored within the scope of the proposed intervention (for example, autism spectrum or intellectual development disorders or, domestic violence, neglect or abuse prior to the adverse situation);\n* Do not speak or understand Portuguese","3 Years","6 Years",{"count":64,"type":21},[24],"In this study we aim to verify the effectiveness of a psychological intervention for preschool children, 3 to 6 years of age, with psychological problems or disorders, arising from adversity, Skills4Parenting+.\n\nSkills4Parenting+, with 6 to 8 weekly sessions, aims to treat the child's psychological problems or disorders, based on parental reflective functioning, to activate and develop parents' positive parenting skills, in response to situations of adversity.\n\nTo assess the effectiveness, we plan to conduct an a simple two-arm RCT study, where children are randomly allocated to an immediate intervention group (IIG) or a delayed intervention group (DIG).\n\nThe IIG will be assessed at 3 time-points: Time 0 (pre-test: before the 1st session); Time 1 (post-test: after the last session) and Time 2 (follow-up: 8 weeks after the last session). The DIG will be assessed at 4 time-points: Time 0 (pre-test 1: before the 1st session); Time 0+ (pre-test 2: 8 weeks after the 1st session); Time 1 (post-test: after the last session) and Time 2 (follow up: 8 weeks after the last session). A time period of 8 weeks will be maintained between each time point.\n\nIn this study, we expect the (1) psychological intervention to significantly diminish the child's psychological problems or disorders (from pretest to posttest); (2) parental reflective functioning will mediate the effect of the psychological intervention on child's psychological problems or disorders; (3) the children from IIG will demonstrate a significant improvement in their mental health, in comparison to the children from the DIG; and (4) for the effects of the psychological intervention (i.e., improvement in the child's mental health) to be maintained in the medium-term (from posttest to follow-up).",[140,141],"Externalizing Problems","Internalizing Problems",[143,144,145,146,147,148,149],"Positive Parenting","Pre-school Children","Parents","Adversity","Psychological Problems","Parental Reflective Functioning","Psychological Disorders","2025-04-04",{"date":152,"type":46},"2025-04-08",{"date":154,"type":46},"2021-02-04",{"date":156,"type":21},"2025-12-31",{"name":52,"class":53},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":164,"eligibilityCriteria":165,"healthyVolunteers":100,"sex":17,"minAge":18,"maxAge":166,"enrollmentInfo":167,"targetDuration":4,"studyType":22,"phases":168,"briefSummary":169,"conditions":170,"keywords":172,"overallStatus":176,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":180,"completionDateStruct":182,"leadSponsor":184,"locationsCount":4},"100540508","can-exercise-rewire-the-brain-addiction-circuitry-100540508","NCT06317753","Can Exercise Rewire the Brain Addiction Circuitry?","Can Exercise Rewire the Brain Addiction Circuitry? A Randomized Trial of Exercise and Binge Drinking","REWIRED","Inclusion Criteria:\n\n* binge drinking \\> or = 5 ; \\> or =4 for women alcoholic drinks\n* in the same time window (±2h)\n* at least once per month\n* \\\u003C150 minutes of physical activity per week\n\nExclusion Criteria:\n\n* Major and\u002For unstable medical conditions\n* Physical limitations that may constraint the practice of exercise\n* Cardiovascular and respiratory insufficiency\n* History of traumatic brain injury or neurological disorder\n* Non-corrected sensory deficits\n* Personal history of psychopathological disorders\n* Family history of alcoholism or substance abuse in first degree relatives\n* Consumption of medical drugs with psychoactive effects (e.g., sedatives or anxiolytics) during the month previous to the assessment\n* Use of illegal drugs and AUDIT scores \\>20\n* MRI contraindications\n* Current or previous (past year) participation in a physical exercise program","24 Years",{"count":64,"type":21},[24],"The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers. This proposal will advance knowledge on how exercise may modulate the neurocircuitry of addiction. Uncovering the neurobiological mechanisms underlying the interactive neural effects of exercise and alcohol intake may provide additional scientific insights for the development of preventive and intervention programs for youth BD and AUD.",[171],"Physical Exercise",[173,174,175],"Addiction circuitry","Binge drinking","Neuroimaging","NOT_YET_RECRUITING","2025-03-31",{"date":179,"type":46},"2025-04-03",{"date":181,"type":21},"2026-01",{"date":183,"type":21},"2027-12",{"name":52,"class":53},{"id":186,"slug":187,"hasResults":11,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":100,"sex":17,"minAge":193,"maxAge":194,"enrollmentInfo":195,"targetDuration":4,"studyType":22,"phases":197,"briefSummary":198,"conditions":199,"keywords":201,"overallStatus":176,"whyStopped":4,"lastUpdateSubmitDate":205,"lastUpdatePostDateStruct":206,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":4},"100475535","promoting-inclusive-education-through-executive-functions-100475535","NCT05472194","Promoting Inclusive Education Through Executive Functions","Promoting Inclusive Education Through Executive Functions - Study Protocol of a Randomized Control Trial","EduFun","Inclusion Criteria:\n\n* Typically developed children of 5, 6, and 7 years old attending the regular curriculum at public educational services -kindergarten and elementary school.\n\nExclusion Criteria:\n\n* Presence or history of cognitive deficits, neurological or psychiatric condition.","5 Years","7 Years",{"count":196,"type":21},470,[24],"Background: Recently governments worldwide have been doing enormous efforts to ensuring egalitarian educational opportunities for all children. However, the number of children that remain out of the school or lack proficiency in academic performance is still very worrying. One of the factors that seems to contribute to such inequalities is socioeconomic status (SES). SES strongly impacts the developmental trajectory of both the brain and cognitive abilities as off early childhood, further affecting learning and academic success.\n\nDespite the great interest in building inclusive societies and the promising results of executive functions' training programs for leveling the SES-achievement disparities, only a few studies have actually included schools from low-SES settings and lack a comprehensive, evidence-based background underlying the intervention protocols. Thus, with a preventive emphasis, the current project aims to implementing and evaluating a cost-effective game-based training protocol to promote and boost the development of executive functions in preschool and elementary school-aged children from disadvantaged contexts, ultimately contributing to prevent school dropout and reduce academic inequalities.",[200],"Cognitive Training",[202,203,204],"Inclusive Education","Executive Functions","Cognitive Tools","2024-12-04",{"date":207,"type":46},"2024-12-06",{"date":209,"type":21},"2025-09",{"date":211,"type":21},"2027-12-09",{"name":52,"class":53},""]