[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Mississippi Medical Center\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":370},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,43,72,98,125,150,177,198,233,257,281,306,335],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100284932","phase-2-progesterone-to-enhance-the-efficacy-and-success-of-expectantly-managed-preterm-severesuperimposed-preeclampsia-100284932",false,"NCT02989025","Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe\u002FSuperimposed Preeclampsia","Progesterone to Enhance the Efficacy and Success of Expectantly Managed Preterm Severe\u002FSuperimposed Preeclampsia-The PROGRESS Pilot Study","PROGRESS","Inclusion Criteria:\n\n* UMMC antepartum patients with preterm PE between 23 0\u002F7ths and 34 0\u002F7ths weeks gestation when initially evaluated\n* Willing and able to understand study procedures and to provide informed consent\n\nExclusion Criteria:\n\n* \\>33 weeks gestational age or \\\u003C23 weeks gestation\n* Maternal compromise requiring emergent delivery (ongoing placental abruption, DIC, pulmonary edema).\n* Fetal compromise requiring emergent delivery (fetal bradycardia, recurrent late fetal heart rate decelerations, minimal to absent fetal heart rate variability).\n* Parameters according to current practice guidelines that exclude a patient from expectant management include the following:\n* Preterm premature rupture of membranes (PPROM) \\> 34 weeks gestation;\n* Platelet count \\\u003C 100,000\u002Fmicroliter (thrombocytopenia) with evidence of HELLP syndrome;\n* Persistently abnormal hepatic enzyme concentrations (twice or more upper normal values);\n* Severe fetal growth restriction (ultrasound-estimated fetal weight less than fifth percentile);\n* Severe Oligohydramnios (AFI \\\u003C 5cm)\n* Reversal of end diastolic flow(REDF) in umbilical artery Doppler testing;\n* Recurrent (\\> 2 readings \\> 30 minutes apart) severe hypertension despite antihypertensive therapy;\n* Eclampsia;\n* Pulmonary edema;\n* Abruption placentae;\n* Nonreassuring fetal status during daily testing (biophysical profile \\\u003C4\u002F10 and\u002For recurrent variable or late decelerations);\n* IUFD","FEMALE","18 Years","45 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"PHASE2","The purpose of this study is to learn if giving 17-hydroxyprogesterone caproate (17 OHPC) to mothers with preeclampsia diagnosed before 34 weeks gestation improves mother and baby outcomes.",[28,29],"Pregnancy","Preeclampsia (PE)","RECRUITING","2026-04-27",{"date":33,"type":34},"2026-05-01","ACTUAL",{"date":36,"type":34},"2017-05-22",{"date":38,"type":22},"2027-01-31",{"name":40,"class":41},"University of Mississippi Medical Center","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":47,"acronym":48,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":23,"phases":53,"briefSummary":55,"conditions":56,"keywords":58,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":71,"locationsCount":42},"100628440","evaluation-of-endobronchial-ultrasound-needle-cleaning-techniques-and-their-impact-on-specimen-contamination-100628440","NCT07461662","Evaluation of Endobronchial Ultrasound Needle Cleaning Techniques and Their Impact on Specimen Contamination","EBUS","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Patients undergoing standard-of-care EBUS bronchoscopy for evaluation of suspected lung malignancy\n* Patients undergoing sampling of 2 or more lymph node stations during EBUS bronchoscopy\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* Age less than 18\n* Recent (1 month or less) radiation or procedural manipulation of lymph node stations that may significantly change lymph node architecture","ALL",{"count":52,"type":22},204,[54],"NA","Endobronchial ultrasound (EBUS) bronchoscopy is commonly used to sample lymph nodes in patients with suspected or known lung cancer to determine the stage of the disease. Accurate staging is essential as it directly impacts treatment decisions and prognosis. During EBUS procedures, needles are often reused across multiple lymph node stations and are typically flushed with saline between samples. This raises the concern that residual tumor cells may contaminate the samples and could potentially incorrectly upstage disease.\n\nThis prospective study will evaluate the current technique used during EBUS procedures to determine if more intensive cleaning leads to reduced cellular contamination without affecting diagnostics. Patients undergoing an EBUS procedure for diagnosis with a large mass and a high probability of malignancy will be selected for the study. Rapid On-Site Examination (ROSE) will be used at the bedside to determine the presence of abnormal cells. Following the final pass, before moving to the next station, the needle will be flushed with saline as normal and then flushed again into another container to evaluate the presence of residual cells. The outcome may help EBUS needle handling practices and improve lung cancer staging accuracy.\n\nNo additional invasive procedures are performed as part of this study; all analyses utilize material obtained during routine EBUS needle flushing, with no added needle sticks or alteration of clinical care.",[57],"Lung Cancer (Locally Advanced or Metastatic)",[59,60,61,62],"Lung Cancer","Endobronchial ultrasound (EBUS) bronchoscopy","Cytologic Contamination","Cancer Staging","NOT_YET_RECRUITING","2026-03-04",{"date":66,"type":34},"2026-03-10",{"date":68,"type":22},"2026-04-01",{"date":70,"type":22},"2027-08-31",{"name":40,"class":41},{"id":73,"slug":74,"hasResults":11,"nctId":75,"briefTitle":76,"officialTitle":77,"acronym":4,"eligibilityCriteria":78,"healthyVolunteers":79,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":80,"targetDuration":4,"studyType":23,"phases":82,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":90,"lastUpdatePostDateStruct":91,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":4},"100626129","a-web-based-text-messaging-for-tobacco-cessation-in-rural-mississippi-100626129","NCT07431619","A Web-Based Text Messaging for Tobacco Cessation in Rural Mississippi","A Randomized Trial of a Web-Based Text Messaging for Tobacco Cessation in Rural Mississippi","Inclusion Criteria:\n\n* ≥18 years-old\n* resident of rural Mississippi (verified by a ZIP code)\n* not planning to move out of Mississippi during the next 6 months\n* own a personal cellphone with an unlimited texting plan\n* having the intention to quit tobacco and having made at least 1 quit attempt in the past 6 months\n* smokes ≥5 cigarettes per day during the past 6 months (for the cigarette smoking condition)\n* uses SLT ≥3 times per day during the past 6 months (for the SLT condition)\n* concurrent use of cigarettes and SLT on ≥15 days monthly during the past 6 months (for the dual use condition).\n\nExclusion Criteria:\n\n* a self-report of being diagnosed with or taking medications for severe mental illness\n* refusal to provide informed consent\n* having no intention to quit tobacco\n* currently using electronic cigarettes or pharmacological medications for tobacco cessation\n* currently participating in another RCT.",true,{"count":81,"type":22},150,[54],"Cigarette smoking prevalence has decreased to \\~12% in 2022; however, over 40 million U.S. adults were current cigarette smokers in the same year. Rural-urban disparities in tobacco use are persistent, with higher tobacco use and lower cessation in rural areas. Less research has been dedicated to addressing rural-urban tobacco use disparities, perhaps due to logistics, difficulty recruiting and following participants from rural areas, and challenges with conducting clinic-based interventions. Mississippi is one of the states with higher rurality, as 79% of Mississippi counties are classified as rural. Additionally, Mississippi has a higher prevalence of tobacco use and lower cessation rates compared with the national average. Moreover, Mississippi is one of the few states that did not expand Medicaid, which covers comprehensive tobacco cessation services. This may add to the persistent disparity in tobacco use and cessation between rural and urban Mississippians. To overcome these challenges, the investigators propose a randomized clinical trial to test the effectiveness of theory-driven text messaging for tobacco cessation in rural Mississippi among users of cigarettes, smokeless tobacco (SLT), and dual users of cigarettes and SLT. Specifically, this proposal has the following specific aims: (1) To conduct a two-arm, randomized, clinical trial (RCT) of a web-based, text messaging approach for tobacco cessation among cigarette smokers, SLT users and dual users from rural Mississippi; (2) To assess the effectiveness of a web-based, text messaging intervention on tobacco cessation among cigarette smokers, SLT users and dual users; and (3) To identify barriers to and facilitators of tobacco cessation using ecological momentary assessment (EMA). To achieve these aims, a sample of 150 tobacco users (50 cigarette smokers, 50 SLT users, 50 dual users) who intend to quit and have made ≥1 quit attempt in the past 6 months will be recruited via a web-based, crowdsourcing platform (ResearchMatch.org). ResearchMatch.org is a large crowdsourcing platform that facilitates recruitment of a desired research sample from an online panel. Eligible participants will be randomized to intervention and control arms and will be asked to set up a quit date within the first 4 weeks post-intervention. Participants in the intervention arm will receive up to 3 motivational text messages daily during the first 4 weeks, and up to 2 daily during the last 2 weeks. The same frequency will be followed for the control group, but they will receive non-specific text messages. Participants will also receive a daily, midday text message during weeks 1-10 post-intervention to document the barriers and facilitators of tobacco cessation using EMA approach. After week 10 and to the end of 6 months post-intervention, the frequency of EMA texts will be reduced to once per week. Two-way text messaging will be facilitated via a web-based service called Mosio. The investigators will assess prolonged and 7-day point prevalence abstinence at 6 weeks, 3 months, and 6 months post-intervention. This project represents an attempt to test a simple and innovative approach to reducing rural-urban tobacco use disparities and overall tobacco-related morbidity and mortality. The findings can facilitate applying for extramural funding for a larger trial.",[85],"Tobacco Cessation",[87,88,89],"Rural","Text messaging","Smokeless tobacco","2026-02-18",{"date":92,"type":34},"2026-02-24",{"date":94,"type":22},"2026-12-01",{"date":96,"type":22},"2027-11-30",{"name":40,"class":41},{"id":99,"slug":100,"hasResults":11,"nctId":101,"briefTitle":102,"officialTitle":103,"acronym":4,"eligibilityCriteria":104,"healthyVolunteers":11,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":105,"targetDuration":4,"studyType":23,"phases":107,"briefSummary":108,"conditions":109,"keywords":112,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":116,"lastUpdatePostDateStruct":117,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},"100607484","weight-bearing-after-pelvis-and-acetabulum-fracture-fixation-100607484","NCT07189156","Weight Bearing After Pelvis and Acetabulum Fracture Fixation","Immediate Versus Delayed Weight Bearing After Fixation of Pelvis and Acetabulum Fractures: A Multicenter Feasibility Randomized Controlled Trial","Inclusion Criteria:\n\n1. Adults 18 years old and above\n2. Patients with surgically treated pelvis or acetabulum fractures\n\nExclusion Criteria:\n\n1. Presence of fractures to the ipsilateral or contralateral lower extremity that would preclude WBAT on the surgically repaired pelvis\u002Facetabulum fracture\n2. Presence of upper extremity injury that would limit weight bearing using an assistive device such as a walker or crutches\n3. Severe injuries to other body systems that would prevent patient from being able to comply with weight bearing protocol\n4. Presence of significant psychiatric or cognitive disorder or disability that would prevent patient from being able to comply with weight bearing protocol\n5. Pre-injury non-ambulatory status\n6. Suspected issues with follow-up\n7. Language barriers precluding obtaining adequate informed consent",{"count":106,"type":22},200,[54],"The goal of this study to determine if a randomized clinical trial of immediate versus delayed weight bearing after undergoing surgical fixation of a pelvis or acetabulum fracture is feasible. The main questions it aims to answer are:\n\nAre surgeons willing to allow inclusion of their patients into such a trial? Are patients willing to participate in such a trial? Will patients be compliant with assigned weight bearing status in such a trial? Can good patient follow-up be obtained in such a trial? Is participation in such a trial safe?\n\nPatients from 7 medical centers will be enrolled, and randomized to immediate weight bearing as tolerated (WBAT) versus delayed WBAT (for 6-12 weeks). Feasibility metrics revolving around enrollment, follow-up, and documentation will be monitored, as well as medical and surgical complications. This pilot study will help inform feasibility and design of a larger definitive multicenter randomized controlled trial (RCT) on this topic.",[110,111],"Pelvis Fractures","Acetabulum Fractures",[113,110,111,114,115],"Weight Bearing","Immediate Weight Bearing","Early Weight Bearing","2025-09-16",{"date":118,"type":34},"2025-09-23",{"date":120,"type":22},"2025-10",{"date":122,"type":22},"2028-12",{"name":40,"class":41},7,{"id":126,"slug":127,"hasResults":11,"nctId":128,"briefTitle":129,"officialTitle":129,"acronym":4,"eligibilityCriteria":130,"healthyVolunteers":11,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":131,"targetDuration":4,"studyType":23,"phases":133,"briefSummary":134,"conditions":135,"keywords":137,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":42},"100590916","evaluation-of-home-based-telerehabilitation-platform-to-augment-orthopedic-rehabilitation-100590916","NCT06973642","Evaluation of Home-based Telerehabilitation Platform to Augment Orthopedic Rehabilitation","Inclusion Criteria:\n\n* Patients that are candidates for anterior cruciate ligament reconstruction.\n\nExclusion Criteria:\n\n* Visual impairment greater than 20\u002F200 with the use of corrective lenses\n* Does not own or have consistent access to a phone with data capabilities\n* Has been informed by their healthcare provider that they should not participate in physical therapy services\n* Participants can be excluded from the study at any time if the physical therapist determines the patient is not an appropriate candidate for telehealth therapy.",{"count":132,"type":22},15,[54],"The goal of this study is to assess the feasibility of utilizing a telehealth rehabilitation platform to increase patient access for individuals who have undergone orthopedic surgery.\n\nPatient participants will be seen via telehealth until they are able to be seen by an in-person physical therapist of their choice.\n\nProvider participants will be the physical therapist who are providing physical therapy services through the telehealth application.\n\nData collection:\n\nPatient and provider post surveys Home program and scheduled visit compliance rate Healthcare information in keeping with Stand of care physical therapy practices\n\nFeasibility criteria will be assessed to determine whether this modality improves physical therapy access for patients living in rural areas.",[136],"Anterior Cruciate Ligament Reconstruction Rehabilitation",[138,139,140,141],"telerehabilitation","telehealth","physical therapy","Anterior Cruciate Ligament Rehabilitation","2025-07-22",{"date":144,"type":34},"2025-07-24",{"date":146,"type":34},"2025-06-01",{"date":148,"type":22},"2026-12-31",{"name":40,"class":41},{"id":151,"slug":152,"hasResults":11,"nctId":153,"briefTitle":154,"officialTitle":154,"acronym":155,"eligibilityCriteria":156,"healthyVolunteers":79,"sex":50,"minAge":18,"maxAge":157,"enrollmentInfo":158,"targetDuration":4,"studyType":23,"phases":160,"briefSummary":161,"conditions":162,"keywords":164,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":176},"100598405","mississippi-community-engagement-alliance-ms-ceal-fostering-community-solutions-100598405","NCT07071064","Mississippi Community Engagement Alliance (MS CEAL): Fostering Community Solutions","MS CEAL","Inclusion Criteria:\n\n* Self-identify as Black\u002FAfrican American, Latinx, or Choctaw\n* Age between 18-75\n\nExclusion Criteria:\n\n* Cognitive impairment\n* Pregnant or plans to become pregnant within 12 months\n* Currently enrolled in a food box delivery program or nutrition education program\n* Food allergies that will be exacerbated with food box distribution","75 Years",{"count":159,"type":22},400,[54],"The Mississippi Community Engagement Alliance (MS CEAL) Team proposes to address the complexities of Mississippi's health issues and social determinants of health through its Fostering Community Solutions (FOCUS) Project, with two objectives: (1) advance the health and wellbeing of Mississippi's populations experiencing differing health outcomes; and (2) enhance the resilience and power within communities to disseminate and implement evidence-based interventions. This study's specific aims include: (1) examine whether the inclusion of a nutrition education program increases fruit and vegetable consumption in a food box distribution program and (2) recruit and train community nutrition liaisons to implement sustainable community strategies to longitudinally support nutrition security. The primary outcome for the first specific aim will be fruit and vegetable consumption. Secondary outcome measures will include changes in perceptions and knowledge related to food consumption and dietary intake. Clinical outcomes will include changes in blood pressure, blood sugar, and cholesterol. For Specific Aim 2, outcomes will include the ability to recruit community nutrition liaisons at each site, the number of trainings, pre\u002Fpost training assessments, and outreach metrics.",[163],"Nutrition Security",[163,165,166,167],"Health Literacy","Health Promotion","Community Engaged Research","2025-07-15",{"date":170,"type":34},"2025-07-17",{"date":172,"type":34},"2025-05-17",{"date":174,"type":22},"2027-03-31",{"name":40,"class":41},4,{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":79,"sex":50,"minAge":18,"maxAge":157,"enrollmentInfo":183,"targetDuration":4,"studyType":184,"phases":4,"briefSummary":185,"conditions":186,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":42},"100596981","the-epidemiology-and-pathophysiology-of-kidney-disease-in-hfpef-with-obesity-100596981","NCT07052539","The Epidemiology and Pathophysiology of Kidney Disease in HFpEF With Obesity","Criteria for Cohort 1: Healthy Participants\n\nInclusion Criteria:\n\n* Adults 18-75 years old\n* Normal kidney function\n* No heart failure\n* BMI 25-30kg\u002Fm2\n\nExclusion Criteria:\n\n* Diagnosis of chronic illness\n* eGFR\\\u003C60mL\u002Fmin\u002F1.73m2\n* Pregnancy or breast feeding\n* History of cutaneous or allergic reaction to iodine-based products of contrast dyes\n* Hemoglobin levels \\\u003C7mg\u002FdL\n* Acute illness or hospitalization event within 3 months\n* Unable to stop NSAIDs\n* Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism\n* Current use of nicotine or recreational drugs, chronic drinker\n\nCriteria for Cohort 2: Obese Participants without HFpEF\n\nInclusion Criteria:\n\n* Adults 18-75 years old\n* eGFR \\>= 60 mL\u002Fmin\u002F1.73m2\n* BMI \\> 35 kg\u002Fm2\n\nExclusion Criteria:\n\n* Diagnosis of Heart Failure\n* Diagnosis of chronic illness\n* eGFR\\\u003C60mL\u002Fmin\u002F1.73m2\n* Pregnancy or breast feeding\n* History of cutaneous or allergic reaction to iodine-based products of contrast dyes\n* Hemoglobin levels \\\u003C7mg\u002FdL\n* Acute illness or hospitalization event within 3 months\n* Unable to stop NSAIDs\n* Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism\n* Current use of nicotine or recreational drugs, chronic drinker\n\nCriteria for Cohort 3: HFpEF and Obese Participants\n\nInclusion Criteria:\n\n* Adults 18-75 years old\n* eGFR \\>= 60 mL\u002Fmin\u002F1.73m2\n* BMI \\> 35 kg\u002Fm2\n* Diagnosis of HFpEF (chart diagnosis, LVEF \\> 55% on echo, H2FPEF score 6-9 or HFA-PEFF score 5 or 6\n\nExclusion Criteria:\n\n* NYHA class III\u002FIV\n* Urinary retention screen +\n* Mobility issues\n* History of RRT or kidney transplant\n* Acute illness\u002Fhospitalization in the past 3 months\n* History of cancer, chemo, or XRT\n* Pregnant\u002Fbreastfeeding\n* History of allergies to contrast\n* Hemoglobin \\\u003C 7\n* Comorbid conditions: MM, amyloidosis, pheochromocytoma, SCD, metastatic brain lesions, advanced kidney disease, liver dysfunction, endotoxemia, hyperthyroidism\n* Unable to stop NSAIDs\n* Current use of nicotine or recreational drugs, chronic drinker",{"count":21,"type":22},"OBSERVATIONAL","This research study wants to learn about Chronic Kidney Disease (CKD) with Obesity, and Heart Failure with preserved Ejection Fraction (HFpEF) and better ways to evaluate these diseases. HFpEF means that the heart is not able to fill properly with blood while it is resting so the amount of blood pumped out to the body is less than it would be if it was filling properly. The study is being done to describe the differences in how the kidneys handle protein and salt in participants with HFpEF and obesity compared to healthy persons.",[187,188,189],"Chronic Kidney Disease","Heart Failure With Preserved Ejection Fraction (HFPEF)","Obesity (Disorder)","2025-06-26",{"date":192,"type":34},"2025-07-04",{"date":194,"type":34},"2022-07-22",{"date":196,"type":22},"2026-07-31",{"name":40,"class":41},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":79,"sex":17,"minAge":205,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":23,"phases":209,"briefSummary":210,"conditions":211,"keywords":216,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":224,"lastUpdatePostDateStruct":225,"startDateStruct":227,"completionDateStruct":229,"leadSponsor":231,"locationsCount":232},"100504101","teen-mom-study-feasibility-trial-100504101","NCT05843903","Teen Mom Study Feasibility Trial","Teen Mom Study Feasibility Trial: A Multicomponent Digital Health Intervention to Improve Cardiometabolic Health in Pregnant Black Adolescents","Inclusion criteria:\n\n* 15- to 19-years\n* Black or African American\n* \\\u003C20 weeks' gestation\n* Enrolled in WIC\n* Residing in 1 of 8 Mississippi Delta Counties\n* English speaking\n* Own or have personal use of a mobile smart phone\n* Singleton pregnancy\n* Plan to carry the fetus to term and keep the infant after birth\n* No history of chronic medical conditions in the past year that could influence weight loss or gain\n\nExclusion Criteria:\n\n* Restrictions on physical activity or exercise","15 Years","19 Years",{"count":208,"type":22},20,[54],"The proposed multicomponent digital health intervention has the potential to significantly impact the trajectory of maternal health in a rural, pregnant, Black adolescent population with the highest risks for cardiometabolic diseases worldwide. The proposed implementation strategy leverages mobile technologies which are ubiquitous across the socioeconomic gradient and proposes to train young adult WIC moms to deliver peer health coaching in a telehealth setting to address social barriers and support behavior change in pregnant, Black adolescent WIC clients in the Mississippi Delta - a rural region where the population is more than two-thirds percent Black and the teen birth rate is the highest in the United States. This is a scalable and sustainable approach to enhance WIC services and improve WIC's impact on population health and cardiometabolic health disparities in Black women.",[212,213,214,215],"Physical Activity","Sedentary Behavior","Gestational Weight Gain","Social Determinants of Health",[217,218,219,220,221,222,223],"implementation science","pragmatic clinical trial","telemedicine","health disparity, minority and vulnerable populations","behavior and behavior mechanisms","adolescent pregnancy","black maternal health","2025-05-13",{"date":226,"type":34},"2025-05-15",{"date":228,"type":34},"2025-04-07",{"date":230,"type":22},"2026-06-01",{"name":40,"class":41},2,{"id":234,"slug":235,"hasResults":11,"nctId":236,"briefTitle":237,"officialTitle":238,"acronym":4,"eligibilityCriteria":239,"healthyVolunteers":11,"sex":17,"minAge":205,"maxAge":206,"enrollmentInfo":240,"targetDuration":4,"studyType":23,"phases":242,"briefSummary":243,"conditions":244,"keywords":246,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":249,"lastUpdatePostDateStruct":250,"startDateStruct":252,"completionDateStruct":254,"leadSponsor":256,"locationsCount":4},"100532754","teen-mom-study-a-confirmatory-pragmatic-cluster-rct-100532754","NCT06216925","Teen Mom Study: A Confirmatory Pragmatic Cluster RCT","Teen Mom Study: A Confirmatory Pragmatic Cluster Randomized Controlled Trial","Inclusion Criteria:\n\n* Less than 16 weeks pregnant\n* Black or African-American\n* Between 15 and 19 years of age (inclusive)\n* Enrolled in WIC\n* Residing in 1 of 12 counties constituting the Mississippi Delta region\n* Singleton pregnancy\n* Planning to carry the fetus to term\n* English speaking\n* Possession of a mobile device\n\nExclusion Criteria:\n\n* Individuals with physical activity restrictions",{"count":241,"type":22},144,[54],"The goal of this clinical trial is to test the effectiveness of #BabyLetsMove - a 24-week mobile Health and peer health coaching intervention paired with the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) - to increase physical activity and reduce sedentary behavior in pregnant, Black teens in the Mississippi Delta. The main questions it aims to answer are:\n\n* Does #BabyLetsMove increase objective moderate-to-vigorous physical activity and decrease sedentary behavior from ≤16 to 26- and 36-gestational weeks compared to usual WIC care alone?\n* Does # BabyLetsMove decrease the rate of gestational weight gain and mean arterial pressure from ≤16 to 26- and 36-gestational weeks compared to usual WIC care alone?\n* Is #BabyLetsMove a feasible and acceptable intervention according to the RE-AIM framework?\n* Using the Practical, Robust Implementation and Sustainability Model and the Consolidated Framework for Implementation Research, what are the barriers to organizational uptake and how can strategies be improved for future testing?\n\nParticipants will be given three empirically supported behavior goals including (1) watching ≤2 hours of TV or other screen time per day, and (2) walking ≥10,000 steps per day - or - (3) engaging in ≥20 minutes of organized exercise per day.\n\nResearchers will compare the #BabyLetsMove groups to the WIC care only groups to see if the #BabyLetsMove intervention improves traditional WIC care for bettering health outcomes ( amongst pregnant, Black teens in the Mississippi Delta.",[213,212,214,245],"Arterial Pressure",[28,247,248],"Adolescent","Mobile Health","2025-04-23",{"date":251,"type":34},"2025-04-27",{"date":253,"type":22},"2025-08-01",{"date":255,"type":22},"2026-06-30",{"name":40,"class":41},{"id":258,"slug":259,"hasResults":11,"nctId":260,"briefTitle":261,"officialTitle":262,"acronym":263,"eligibilityCriteria":264,"healthyVolunteers":11,"sex":17,"minAge":265,"maxAge":206,"enrollmentInfo":266,"targetDuration":4,"studyType":23,"phases":268,"briefSummary":269,"conditions":270,"keywords":272,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":274,"lastUpdatePostDateStruct":275,"startDateStruct":277,"completionDateStruct":278,"leadSponsor":280,"locationsCount":4},"100569737","knowledge-and-habits-of-pregnant-teens-100569737","NCT06698133","Knowledge and Habits of Pregnant Teens","Knowledge and Habits of Pregnant Teens: Analyzing Nutritional Status, Weight and Infant Birth Weight","KnowTeens","Inclusion Criteria:\n\n* Maternal age 13 - 19 yrs at enrollment\n* \\\u003C 19.6 gestational weeks\n* Ability to understand English\n* Access to a smartphone or internet\n* Willingness to follow study procedures\n* Plan to deliver at UMMC\n* Singleton pregnancy\n\nExclusion Criteria:\n\n* Does not meet the inclusion criteria\n* History of diabetes\n* Current record of substance abuse\n* Mental impairment\n* Eating disorder","13 Years",{"count":267,"type":22},50,[54],"This study examines the link between health literacy, gestational weight gain, and infant birthweight in pregnant teenagers. A randomized trial of 50 participants will be conducted at the University of Mississippi Medical Center. Consent will be obtained from all participants. Both control and intervention groups will complete a 20 questions health literacy assessment at baseline and after eight weeks, along with the ASA24 dietary recall tool twice weekly. The intervention group will join a private social media group created solely for study purposes. This will be a private account, accessible only to participants who are added or invited by the study team.",[271],"Teen Pregnancy",[214,273,165],"Infant Birth Weight","2025-03-26",{"date":276,"type":34},"2025-04-01",{"date":276,"type":22},{"date":279,"type":22},"2025-12",{"name":40,"class":41},{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":285,"acronym":286,"eligibilityCriteria":287,"healthyVolunteers":79,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":288,"targetDuration":4,"studyType":23,"phases":290,"briefSummary":291,"conditions":292,"keywords":295,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":298,"lastUpdatePostDateStruct":299,"startDateStruct":301,"completionDateStruct":303,"leadSponsor":305,"locationsCount":4},"100576850","text-based-motivational-interviewing-intervention-to-promote-exclusive-breastfeeding-rates-100576850","NCT06790654","Text-based Motivational Interviewing Intervention to Promote Exclusive Breastfeeding Rates","Text-MI","Inclusion Criteria:\n\n* Mothers who have given birth to a healthy full-term infant, intend to breastfeed, and possess a mobile device capable of receiving texts\n\nExclusion Criteria:\n\n* Exclusion criteria include age \\\u003C 18, contraindications to breastfeeding, substance use, or multiple gestation.",{"count":289,"type":22},30,[54],"The goal of this clinical trial is to evaluate whether a text-based motivational interviewing (MI) intervention can increase exclusive breastfeeding rates and breastfeeding self-efficacy in mothers of healthy full-term infants. This study focuses on addressing breastfeeding barriers, particularly among mothers in underserved and rural populations.\n\nThe main questions it aims to answer are:\n\n* Does a text-based MI intervention improve exclusive breastfeeding rates at two, four, and six weeks postpartum?\n* Does the intervention increase maternal breastfeeding self-efficacy during the same period?\n\nResearchers will compare the outcomes of mothers receiving the text-based MI intervention to standard breastfeeding support to assess its feasibility, acceptability, and initial effectiveness.\n\nParticipants will:\n\n* Receive weekly personalized motivational text messages for six weeks postpartum.\n* Engage in interactive exchanges with MI-trained interviewers addressing breastfeeding challenges.\n* Complete surveys at baseline, mid-intervention, and post-intervention to assess breastfeeding behaviors and self-efficacy.",[293,294],"Breastfeeding Rate","Breastfeeding Self-Efficacy",[296,297],"breastfeeding","motivational interviewing","2025-01-17",{"date":300,"type":34},"2025-01-24",{"date":302,"type":22},"2025-03",{"date":304,"type":22},"2025-11",{"name":40,"class":41},{"id":307,"slug":308,"hasResults":11,"nctId":309,"briefTitle":310,"officialTitle":311,"acronym":312,"eligibilityCriteria":313,"healthyVolunteers":11,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":314,"targetDuration":4,"studyType":23,"phases":316,"briefSummary":317,"conditions":318,"keywords":320,"overallStatus":63,"whyStopped":4,"lastUpdateSubmitDate":327,"lastUpdatePostDateStruct":328,"startDateStruct":330,"completionDateStruct":332,"leadSponsor":334,"locationsCount":42},"100572704","mississippi-violence-injury-prevention-vip-program-100572704","NCT06736730","Mississippi Violence Injury Prevention (VIP) Program","A Proposal to Establish the Mississippi Violence Injury Prevention (VIP) Program","MS-VIP","Inclusion Criteria:\n\n* Age 18 years or older\n* Firearm injury within the last 24 hours prior to their arrival at the University of Mississippi Medical Center\n* Residency\u002Fhome address within one of the designated clusters.\n* Be approached by the research team within 72 hours of arrival.\n* Ability to understand the clinical trial, sign the consent form, and commit to follow-ups.\n* Ability and willingness to engage in all aspects of the intervention arm (must agree to Operation Good, Survey Participation, and Unrestricted Cash Assistance, these interventions\u002Fevaluations cannot be separated)\n\nExclusion Criteria:\n\n* Self-inflicted gunshot wounds\n* Less than 18 years of age\n* Patients who are incarcerated or in-custody\n* Patients who are unable to understand the clinical trial or sign consent (whether from intoxication, injury, or other cause)\n* Patients unable to commit to follow-up or be contacted through routine means",{"count":315,"type":22},500,[54],"This clinical trial is designed to evaluate the effectiveness of three interventions aimed at preventing violence and supporting those affected by it. Over next three years, the impact of these interventions on key areas will be measured, including the incidence of firearm injuries, the recovery of victims, the occurrence of retaliation and re-injury, and health economics. The interventions are developed based on data collected from a comprehensive needs assessment, community summit, retrospective medical chart reviews, and focus group sessions. The defined interventions are as follows:\n\nIntervention A - Integration of an existing community-based intervention program with Hospital services intervention B - Unrestricted Cash Assistance Intervention C - Mobile Community Support Services\n\nAdditionally, the investigators will implement a detailed violence-focused survey for firearm survivors at the time of study enrollment. Follow-up is planned at 3,6 and 12 months. The results of this trial (including analyses of firearm injury rates, recovery outcomes, retaliation\u002Fre-injury occurrences, and economic data) will be shared with the affected communities and stakeholders to promote ongoing improvement and support.",[319],"Gun Shot Wound",[321,322,323,324,325,326],"Violence prevention","Community-based interventions","Health economics of violence","Clinical trial on violence prevention","Firearm injury prevention","Retaliation and reinjury","2025-01-13",{"date":329,"type":34},"2025-01-16",{"date":331,"type":22},"2025-03-01",{"date":333,"type":22},"2028-06-30",{"name":40,"class":41},{"id":336,"slug":337,"hasResults":11,"nctId":338,"briefTitle":339,"officialTitle":340,"acronym":4,"eligibilityCriteria":341,"healthyVolunteers":11,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":342,"targetDuration":4,"studyType":23,"phases":344,"briefSummary":346,"conditions":347,"keywords":352,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":232},"100537145","early-phase-1-neuromodulation-to-reduce-muscle-stiffness-following-spinal-cord-injury-100537145","NCT06274021","Neuromodulation to Reduce Muscle Stiffness Following Spinal Cord Injury","Shared and Distinct Antispastic Effects of Electrical and Pharmacological Neuromodulation","Inclusion criteria:\n\n* Age 18 years or older\n* History of spinal cord injury\n* Time since diagnosis longer than six months\n* Presence of spasticity in the lower limbs (≥ 3 on the Numerical Rating Scale of Spasticity Severity \\[range from 0 to 10\\])\n* If needed, agreement to reduce antispastic medication\n\nExclusion criteria:\n\n* Neurological level of spinal cord injury below T11\n* Ventilatory-dependent\n* Change in neurological status over the past 2 months\n* Rigidity, contraction, or passive range of motion of less than 40 deg in both knee joints\n* Botulinum toxin injections in lower extremities in the previous 3 months before enrollment\n* Systolic blood pressure at rest lower than 90 mm Hg\n* Implanted active devices (e.g., intrathecal baclofen pumps)\n* Passive implants (plates, screws) between T11 and L2 vertebras\n* Skin conditions precluding placement of electrodes\n* Pressure ulcers stage 2 or higher on the gluteal area or lower extremities\n* Receiving antibiotics for infections\n* Pregnancy\n* Difficulty following instructions\n* Participation in another study with investigational drugs or devices within the 30 days preceding and during the present study\n* Other medical risks\u002Fcontraindications as determined by the study physicians",{"count":343,"type":22},16,[345],"EARLY_PHASE1","People with spinal cord injuries may experience muscle tightness or uncontrollable spasms. This study is being conducted to investigate whether transcutaneous spinal stimulation can improve these symptoms. Transcutaneous spinal stimulation is a non-surgical intervention by applying electrical currents using skin electrodes over the lower back and belly.\n\nThe investigators want to see how well the intervention of transcutaneous spinal stimulation performs by testing different levels of stimulation pulse rates. Also, transcutaneous spinal stimulation is compared to muscle relaxants such as baclofen and tizanidine, commonly given to people with spinal cord injuries, to reduce muscle stiffness and spasms. By doing this, the investigators hope to discover if transcutaneous spinal stimulation similarly reduces muscle spasms and stiffness or if combining both methods works best. This could help improve treatment options for people with spinal cord injuries in the future.",[348,349,350,351],"Spinal Cord Injuries","Spinal Cord Injury","Spinal Cord Injury Cervical","Spinal Cord Injury Thoracic",[349,353,354,355,356,357,358,359,360,361],"Neuromodulation","Electrical Stimulation","Spinal Cord Stimulation","Spasticity","Transcutaneous Spinal Stimulation","Lower extremity","Transcutaneous spinal cord stimulation","Paralysis","Spinal reflex","2024-06-28",{"date":364,"type":34},"2024-07-01",{"date":366,"type":34},"2024-03-01",{"date":368,"type":22},"2025-12-31",{"name":40,"class":41},""]