[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Modena and Reggio Emilia\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":363},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,13,0,[8,52,79,99,123,158,180,204,222,244,284,313,342],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":24,"conditions":25,"keywords":27,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":41,"lastUpdatePostDateStruct":42,"startDateStruct":45,"completionDateStruct":47,"leadSponsor":49,"locationsCount":4},"100624037","open-ipf-observational-prediction-model-for-clinical-outcomes-in-idiopathic-pulmonary-fibrosis-100624037",false,"NCT07404423","OPEN-IPF: Observational Prediction modEl for cliNical Outcomes in Idiopathic Pulmonary Fibrosis","Observational Prediction Model for Clinical Outcomes in Idiopathic Pulmonary Fibrosis: a Multicentre, ML-driven Study (OPEN-IPF)","OPEN-IPF","Inclusion Criteria:\n\n* Age ≥18 years\n* Diagnosis of idiopathic pulmonary fibrosis established according to international guidelines and local multidisciplinary team (MDT) assessment\n* Availability of baseline clinical and functional data\n* Availability of follow-up data for at least 12 months, or until a clinically relevant event (e.g., death, lung transplantation)\n\nExclusion Criteria:\n\n* Interstitial lung disease other than IPF\n* Lung transplantation performed before the baseline (index) date\n* Absence of any follow-up information after baseline","ALL","18 Years","90 Years",{"count":21,"type":22},1000,"ESTIMATED","OBSERVATIONAL","Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with marked inter-individual heterogeneity in trajectories and outcomes. Despite antifibrotic therapies, reliable risk stratification in routine practice remains suboptimal. OPEN-IPF is a multicentre retrospective observational cohort study designed to build a harmonised real-world dataset across Italian IPF referral centres to enable the development and external validation of machine-learning (ML) models predicting clinically relevant outcomes.",[26],"Idiopathic Pulmonary Fibrosis",[28,29,30,31,32,33,34,35,36,37,38,39],"Idiopathic pulmonary fibrosis","IPF","Disease progression","Acute exacerbation","Antifibrotic therapy","Nintedanib","Pirfenidone","Real-world data","Machine learning","Prognostic model","External validation","Multicentre cohort","NOT_YET_RECRUITING","2026-02-04",{"date":43,"type":44},"2026-02-11","ACTUAL",{"date":46,"type":22},"2026-06-01",{"date":48,"type":22},"2027-06-01",{"name":50,"class":51},"University of Modena and Reggio Emilia","OTHER",{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":56,"acronym":57,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":60,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":62,"conditions":63,"keywords":65,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":73,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},"100621643","hoxb7-and-linked-tissue-and-blood-biomarkers-in-the-lungs-of-patients-with-pulmonary-fibrosis-100621643","NCT07373288","HOXB7 and Linked Tissue and Blood Biomarkers in the Lungs of Patients With Pulmonary Fibrosis","HOGWARTS","Inclusion Criteria:\n\n* Adults aged 18 to 80 with clinical suspicion of pulmonary fibrosis\n* Availability of fresh lung tissue from biopsy or lung explant\n* Signed informed consent for research use of biological material and data\n\nExclusion Criteria:\n\n\\- Refusal to sign informed consent","80 Years",{"count":61,"type":22},80,"This pilot, multicenter, interventional study investigates the expression of HOXB7 and its associated molecular pathway in lung tissue and blood-derived exosomes from patients with pulmonary fibrosis (PF), including idiopathic pulmonary fibrosis (IPF). Using RNA sequencing (RNA-Seq) and proteomic analysis via mass spectrometry (MS), the study aims to identify tissue and circulating biomarkers associated with fibrosis progression. The study compares different biopsy techniques (surgical vs. transbronchial cryobiopsy) and also includes a control group of patients undergoing lung resection for non-fibrotic conditions.",[64],"Fibrosis, Pulmonary",[66,67,68,69],"Idiopathic pulmonary fiborsis","Criobiopsy","Lung proteomic","Lung transcriptomic","RECRUITING","2026-02-03",{"date":41,"type":44},{"date":74,"type":44},"2023-07-01",{"date":76,"type":22},"2030-07-01",{"name":50,"class":51},1,{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":84,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":88,"conditions":89,"keywords":90,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":97,"leadSponsor":98,"locationsCount":78},"100463128","inspiratory-effort-assessed-through-nasal-pressure-measurement-in-patients-with-idiopathic-pulmonary-fibrosis-100463128","NCT05310669","Inspiratory Effort Assessed Through Nasal Pressure Measurement in Patients With Idiopathic Pulmonary Fibrosis","NASA","Inclusion Criteria:\n\nPatients treated in Center for Rare diseases of Azienda Ospedaliero-Universitaria Policlinico di Modena will be considered eligible if satisfying the following inclusion criteria:\n\n* Patient with IPF and UIP pattern\n* Need for radiological evaluation through HRCT\n\nExclusione criteria\n\n* Age below 18\n* Pregnancy\n* Inability to sign informed consent\n* COPD\n* Neuromuscular diseases\n* Evidence of IPF acute exacerbation",{"count":87,"type":22},100,"Idiopathic Pulmonary Fibrosis (IPF) is a fibrosing progressive interstitial lung disease with unknown etiology, with a median survival of 3 years since first diagnosis. The typical radiologic pattern of the disease is usual interstitial pneumonia (UIP) defined by basal and peripheral (subpleural) predominance and a typical cystic degeneration of lung parenchyma (honeycombing), interstitial fibrotic thickening and traction bronchiectasis. Despite the recent introduction of two antifibrotic treatments (Pirfenidone and Nintendanib) which proved to be successful in slowing the decline of pulmonary function in patients with IPF, a benefit of these therapies on average survival remains yet to be demonstrated.\n\nA significant part of patients affected by IPF die due to progressive worsening of respiratory failure, often accelerated by the insurgence of acute events, like acute exacerbations. Processes leading to the development and progression of IPF are not yet completely understood. We might hypothesize a regenerative deficit in the lungs of subjects affected, due to a dysregulation of repair mechanism in response to repeated damage (inflammatory, mechanics, infectious, chemical) to the alveolar and vascular epithelium. Moreover, mechanism of damage caused by aging in tissues, with a dysfunction in resident stem cell, might contribute to progression. Patients with IPF undergo mechanical alterations of respiratory system due to progressive restrictive deficit caused by reduction in total lung capacity. This functional alteration generates an ineffective and superficial ventilation due to the waste of the majority inspiratory effort spent in ventilating dead anatomical space. When physical effort occurs, the increased ventilatory necessity and the inability to compensate due to functional impairment leads to increased inspiratory effort and subsequent increase in negative intrathoracic pressure. Recent studies have demonstrated how exerting a pressure (for example when the patient is mechanically ventilated) on lung tissue of subjects with IPF and UIP pattern can generate damage due to unfavorable mechanism of mechanotransduction caused by the pathological behavior of fibrotic lung (''squishy ball lung''). Studies investigating inspiratory effort during spontaneous breathing and respiratory failure highlighted how negative values of intrathoracic pressure might induce self induced lung injury.\n\nRespiratory effort can be quantified measuring esophageal pressure through a pressure transducer inserted with a nasogastric tube in the inferior third part of the esophagus. Measuring esophageal pressure is a precise and accurate way of quantifying inspiratory effort, however its use in daily clinical practice is limited by invasiveness of the maneuver, high cost and need for specific clinical training. Physiological studies show that nasal pressure measured at the entrance of the nostril might correlate with esophageal pressure and therefore estimate inspiratory effort of the patient in a noninvasive way.\n\nThe goal of our study is to evaluate the role of respiratory effort during spontaneous breathing as a potential source of mechanical damage (hence favoring disease progression) in subjects with IPF and UIP pattern. The study aims to identify patient with an unfavorable mechanical phenotype defined by the simultaneous presence of UIP pattern and elevated inspiratory effort after physical activity.",[64],[91,92,93],"Inspiratory effort","Lung Damage","Fibrosis progression",{"date":95,"type":44},"2026-02-05",{"date":74,"type":44},{"date":76,"type":22},{"name":50,"class":51},{"id":100,"slug":101,"hasResults":11,"nctId":102,"briefTitle":103,"officialTitle":103,"acronym":104,"eligibilityCriteria":105,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":106,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":108,"conditions":109,"keywords":111,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":78},"100592127","coraline---correlation-between-physiological-and-clinical-variables-and-failure-of-non-invasive-respiratory-support-in-patients-with-acute-respiratory-failure-100592127","NCT06989385","CORALINE - Correlation Between Physiological and Clinical Variables and Failure of Non-Invasive Respiratory Support in Patients With Acute Respiratory Failure","CORALINE","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Hospitalization in the Respiratory Medicine Unit at AOU Policlinico di Modena\n* Acute respiratory failure (hypoxemic and\u002For hypercapnic) with PaO₂\u002FFiO₂ \\\u003C 300 mmHg\n* Undergoing treatment with HFNO or NIV\n\nExclusion Criteria:\n\n* Immediate need for invasive ventilation upon admission\n* Known neuromuscular disease\n* Pregnancy\n* Lack of informed consent",{"count":107,"type":22},325,"This observational study aims to evaluate the relationship between clinical and physiological variables and the failure of non-invasive respiratory support (NIRS), including high-flow nasal oxygen (HFNO) and non-invasive ventilation (NIV), in patients with acute respiratory failure (ARF), both hypoxemic and\u002For hypercapnic. The study includes both retrospective and prospective components. Retrospective data will be collected from patient charts, while prospective data will be collected at defined time points during clinical care. The primary outcome is NIRS failure, defined as the need for orotracheal intubation. Secondary outcomes include in-hospital and 90-day mortality, ICU and hospital length of stay, and duration of non-invasive and invasive support.",[110],"Acute Respiratory Failure",[112,113,114,91],"Acute respiratory failure","High flow nasal cannula","Non-invasive ventilation","2026-01-19",{"date":117,"type":44},"2026-01-22",{"date":119,"type":44},"2024-11-01",{"date":121,"type":22},"2030-01-01",{"name":50,"class":51},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":127,"acronym":128,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":130,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":132,"conditions":133,"keywords":136,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":78},"100612265","melanoma-of-the-skin-and-exposure-to-solar-ultraviolet-radiation-at-work-in-modena-territory-a-case-control-study-to-promote-an-active-search-and-prevention-of-occupational-diseases-based-on-recent-inail-criteria-100612265","NCT07251335","Melanoma of the Skin and Exposure to Solar Ultraviolet Radiation at Work in Modena Territory: a Case-control Study to Promote an Active Search and Prevention of Occupational Diseases Based on Recent INAIL Criteria","Mesur","Inclusion Criteria:\n\n* Be a patient of the Dermatology Clinic at the University Hospital of Modena.\n* Be 18 years of age or older.\n* Have undergone a dermatological screening for a suspected skin lesion.\n* Be able to understand and sign an informed consent form in italian language.\n\nExclusion Criteria:\n\n* Be under 18 years of age.\n* Have cognitive impairment that prevents providing reliable answers to the interview or recalling past exposures.",{"count":131,"type":22},300,"The goal of this observational study is to learn about the link between work-related sun exposure and a specific type of skin cancer called melanoma in people living in the Modena area, Italy.\n\nThe main questions it aims to answer are:\n\n* Is there a connection between working outdoors and developing types of melanoma that are linked to long-term sun exposure?\n* Can we use recent criteria from the Italian workers' compensation authority (Istituto Nazionale per l'Assicurazione contro gli Infortuni sul Lavoro, INAIL) to better identify and report these melanomas as occupational diseases?\n\nParticipants in this study will:\n\n* Be patients of the Modena University Hospital Dermatology Clinic who are already undergoing a skin biopsy for a suspected lesion.\n* Take part in a one-time interview with a trained healthcare worker.\n\nAnswer questions about their:\n\n* Job history and specific work locations (to calculate local UVR exposure).\n* Sun exposure habits at work and in their free\u002Fholiday time.\n* Use of sun protection (e.g., sunscreen, protective clothing).\n* Use of tanning beds.\n* Natural skin color and tendency to sunburn (and other elements to determine their specific skin phototype).\n* Other personal and family health factors.\n\nResearchers will compare two groups:\n\n* Cases: 120 participants who are diagnosed with melanoma after the biopsy.\n* Controls: 180 participants who screened negative for melanoma but may show another skin condition.\n\nBy comparing these groups, researchers aim at better understanding the role of outdoor work as a risk factor for specific melanoma subtypes. For participants diagnosed with a melanoma that is likely linked to their job, the study team will promote its reporting as an occupational disease.",[134,135],"Skin Melanoma","Cutaneous Melanoma",[137,135,138,139,140,141,142,143,144,145,146,147,148,149],"Skin melanoma","Occupational Exposure","Solar Ultraviolet Radiation","Outdoor Workers","Case-Control Study","Occupational Disease","Skin Cancer","Cumulative Sun Damage","Lentigo Maligna Melanoma","Occupational Health","Dermatology","Italy","Occupational Medicine","2025-12-09",{"date":152,"type":44},"2025-12-18",{"date":154,"type":44},"2025-07-07",{"date":156,"type":22},"2027-11",{"name":50,"class":51},{"id":159,"slug":160,"hasResults":11,"nctId":161,"briefTitle":162,"officialTitle":163,"acronym":4,"eligibilityCriteria":164,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":172,"lastUpdatePostDateStruct":173,"startDateStruct":175,"completionDateStruct":177,"leadSponsor":179,"locationsCount":78},"100614309","reflectance-confocal-microscopy-and-molecular-correlation-in-atypical-melanocytic-lesions-100614309","NCT07277920","Reflectance Confocal Microscopy and Molecular Correlation in Atypical Melanocytic Lesions","Evaluation of Reflectance Confocal Microscopy (RCM) Features in Surgically Excised Atypical Melanocytic Lesions and Their Correlation With Next-Generation Sequencing (NGS) Patterns","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Presence of cutaneous lesions with dermoscopic and reflectance confocal microscopy suspicion of melanocytic neoplasia, already scheduled for surgical excision\n* Written informed consent obtained\n\nExclusion Criteria:\n\n* Age \\\u003C 18 years\n* Lesions not scheduled for excision or with uncertain dermoscopic diagnosis\n* Lack of informed consent",{"count":166,"type":22},200,"This observational, prospective cohort study aims to evaluate the diagnostic relevance of Reflectance Confocal Microscopy (RCM) features in atypical melanocytic lesions scheduled for surgical excision, and to correlate these imaging features with molecular profiles obtained through Next-Generation Sequencing (NGS). Approximately 200 consecutive lesions, including atypical nevi and early-stage melanomas, will be analyzed from patients attending the Videomicroscopy and Confocal Clinic at the Dermatology Department of the University Hospital of Modena.\n\nThe primary objective is to assess the diagnostic significance of RCM features-specifically atypical cells and disarrangement of the dermoepidermal junction (DEJ)-for early detection of melanoma. Secondary objectives include correlating RCM morphological patterns with NGS-derived genetic alterations and identifying molecular signatures that differentiate early-stage melanomas from benign nevi.\n\nAll procedures are performed as part of routine clinical care, including dermoscopic and confocal evaluation, surgical excision, histopathology, and molecular analysis on formalin-fixed, paraffin-embedded blocks. Data will be anonymized, securely stored, and analyzed to determine associations between imaging and genetic variables. This study integrates morphological and molecular data to refine diagnostic workflows and improve early melanoma detection.",[169,170,171],"Melanocytic Nevi","Melanoma (Skin Cancer)","Next Generation Sequencing (NGS)","2025-11-29",{"date":174,"type":44},"2025-12-11",{"date":176,"type":44},"2023-11-01",{"date":178,"type":22},"2026-12-31",{"name":50,"class":51},{"id":181,"slug":182,"hasResults":11,"nctId":183,"briefTitle":184,"officialTitle":184,"acronym":185,"eligibilityCriteria":186,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":187,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":189,"conditions":190,"keywords":192,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":197,"startDateStruct":199,"completionDateStruct":201,"leadSponsor":203,"locationsCount":78},"100460946","quantification-of-inspiratory-effort-through-nasal-pressure-in-patients-undergoing-weaning-from-invasive-mechanical-ventilation-and-correlation-with-clinical-outcomes-100460946","NCT05282238","Quantification of Inspiratory Effort Through Nasal Pressure in Patients Undergoing Weaning From Invasive Mechanical Ventilation and Correlation With Clinical Outcomes","NAIVE","Inclusion Criteria:\n\n\\- candidates for endotracheal tube removal.\n\nExclusion Criteria:\n\n* Age under 18\n* Pregnancy\n* Patient unable or unwilling to sign informed consent\n* Neuromuscular diseases\n* Patient with compromised neurological state (Glasgow Coma Scale (GCS) under 14\u002F15)",{"count":188,"type":22},175,"Weaning from invasive mechanical ventilation (MV) constitutes a fundamental procedure in intensive care, covering up to 50% of time spent on ventilation (1). Endotracheal tube (ETT) removal might be an important but delicate step in intensive care setting. Failure and subsequent need for re-intubation can occur in up to 20% of cases leading to a significant increase in mortality rates (24%), longer hospital stay and prolonged need for ventilation. Comorbidities such as obesity, COPD and cardiac related diseases might further increase this risk reaching up to 60% of failure in extubation. In this scenario, accurate predictors of weaning failure are far welcomed. The recurrence of respiratory failure after extubation might considerably raise rates of failure, probably due to increased work of breathing in patients after ETT removal. Most recent guidelines on the use of non-invasive ventilation (NIV) suggest using NIV after ETT removal in subjects with high risk of failure. NIV could contribute to reduce work of breathing hence preventing the onset of respiratory failure after extubation. Therefore, measuring inspiratory effort and its variation in weaned patients might help in identifying patients with significant risk of failing extubation. Esophageal pressure swings (DeltaPES) can be measured through a nasogastric tube with a pressure transducer located in the inferior part of the esophagus. DeltaPES is an extremely precise and accurate method to quantify inspiratory effort, however its use in daily clinical practice is limited due to the invasive nature of the maneuver, elevated costs and need for considerable clinical training of operators. Physiological studies have shown a correlation between nasal pressure measured at nostril entrance and esophageal pressure (which in turn is a measure of respiratory effort .\n\nTherefore, measuring nasal pressure could represent a method to quantify inspiratory effort non-invasively, proving to be useful in daily clinical practice.",[191],"Respiratory Failure",[193,194,195],"Weaning Failure","Inspiratory Effort","Nasal Pressure","2025-04-24",{"date":198,"type":44},"2025-04-25",{"date":200,"type":22},"2027-05-01",{"date":202,"type":22},"2033-12-31",{"name":50,"class":51},{"id":205,"slug":206,"hasResults":11,"nctId":207,"briefTitle":208,"officialTitle":208,"acronym":209,"eligibilityCriteria":210,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":211,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":213,"conditions":214,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":216,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":78},"100446844","end-expiratory-trans-pulmonary-pressure-guided-peep-titration-in-patients-with-pulmonary-fibrosis-and-uip-pattern-undergoing-mechanical-ventilation-100446844","NCT05098717","End-expiratory Trans-pulmonary Pressure Guided PEEP Titration in Patients With Pulmonary Fibrosis and UIP Pattern Undergoing Mechanical Ventilation","ETROPON","Inclusion Criteria:\n\n* pulmonary fibrosis with UIP pattern\n* subjected to endotracheal intubation and controlled mechanical ventilation for acute respiratory failure\n* candidate to a trial of PEEP titration according to positive end expiratory pressure.\n\nExclusion Criteria:\n\n* chest wall deformities\n* chronic obstructive pulmonary disease",{"count":212,"type":22},40,"Patients with pulmonary fibrosis and associated usual interstitial pneumonia that require mechanical ventilation for acute respiratory failure experience poor clinical outcomes. This may be influenced by the unfavorable interaction between the fibrotic lung and the stress and strain stimuli generated during controlled ventilation. Although there is no consensus on how to ventilate these patients, much of the recommendations followed in clinical practice are taken from the experience on patients with acute respiratory distress syndrome. Among these, measuring the esophageal pressures and adjusting positive-end expiatory pressure to make trans-pulmonary pressures positive can decrease atelectasis, derecruitment of lung, and cyclical opening and closing of airways and alveoli, thus optimizing lung mechanics and oxygenation. The effect of this strategy on the fibrotic lung has not yet been documented. With this observational study we aim at documenting the effect of PEEP titration maneuver based on end-expiratory trans-pulmonary pressure on lung mechanics of patients with pulmonary fibrosis and UIP pattern,",[26,215],"Mechanical Ventilation Pressure High",{"date":198,"type":44},{"date":218,"type":44},"2023-02-08",{"date":220,"type":22},"2027-01-01",{"name":50,"class":51},{"id":223,"slug":224,"hasResults":11,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":59,"enrollmentInfo":230,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":231,"conditions":232,"keywords":234,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":196,"lastUpdatePostDateStruct":238,"startDateStruct":239,"completionDateStruct":241,"leadSponsor":243,"locationsCount":78},"100413642","inspiratory-effort-in-covid-19-100413642","NCT04666246","Inspiratory Effort in COVID-19","Inspiratory Effort Assessment in Patients With COVID-19 Pneumonia Undergoing Non Invasive Respiratory Support","PERSIA","Inclusion Criteria:\n\n* COVID-19\n* Acute respiratory failure undergoing non-invasive respiratory support\n\nExclusion Criteria:\n\n* Need for immediate endotracheal intubation\n* Chronic respiratory diseases",{"count":212,"type":22},"This study aims at assessing esophageal pressure in patients with acute respiratory failure due to COVID-19 undergoing non invasive respiratory support.",[110,233],"Covid19",[112,235,236,237],"Esophageal pressure","Non invasive respiratory support","COVID-19",{"date":198,"type":44},{"date":240,"type":44},"2020-03-01",{"date":242,"type":22},"2030-02-01",{"name":50,"class":51},{"id":245,"slug":246,"hasResults":11,"nctId":247,"briefTitle":248,"officialTitle":249,"acronym":250,"eligibilityCriteria":251,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":252,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":254,"conditions":255,"keywords":264,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":78},"100534249","the-unmet-needs-of-cancer-survivors-in-ausl-irccs-reggio-emilia-100534249","NCT06236373","The Unmet Needs of Cancer Survivors in Ausl IRCCS Reggio Emilia","The Unmet Needs of Cancer Survivors in Ausl IRCCS Reggio Emilia Reality: a Qualitative Study and Framework Analysis","Survivorship","Inclusion Criteria:\n\n* Adult aged18 years or over.\n* Individuals who have a history of breast, prostate, thyroid, colorectal, multiple myeloma or lymphoma cancer within the past years who have completed the acute phase of treatment, and are in follow-up or are receiving maintenance treatment;\n* Caregivers for an individual who meets the above criteria, who are aged 18 years or over.\n* Stakeholders for individual who meets the above criteria, who are aged 18 years or over.\n\nExclusion Criteria:\n\n* Individuals who do not wish to participate\n* Individuals who do not understand and\u002For speak Italian\n* Individuals with significant cognitive impairment, learning difficulty, or communication difficulty such that understanding the nature of the study, the interview questions, or participating in a focus group or an on-line or in-presence interview would not be practical.",{"count":253,"type":22},45,"This qualitative study seeks to explore the unmet needs of individuals who have recently undergone a cancer diagnosis and completed the acute phase of treatment. The primary objective is to utilize the experiences of patients, caregivers, and stakeholders to enhance the aftercare provided to cancer survivors. By delving into patient perceptions regarding unmet needs in cancer aftercare, the study aims to identify areas for redesigning and improving services to minimize these needs and ultimately enhance patient outcomes. Importantly, the investigation incorporates insights from patients, their caregivers, and stakeholders.\n\nThe research will employ qualitative methods, specifically focus groups and interviews, to gather comprehensive perspectives from individuals in the Ausl IRCCS Reggio Emilia district who have completed treatment for breast, prostate, colorectal, thyroid, and multiple myeloma cancers. Including patients with diverse cancer types is crucial for capturing a broad spectrum of experiences.\n\nDuring data collection, both focus group discussions and interviews will be recorded in audio format and transcribed verbatim. This meticulous approach ensures an accurate representation of participants' voices and experiences. The subsequent analysis will employ a combination of framework and thematic analysis to extract meaningful insights and synthesize the data effectively.\n\nThe study's ultimate goal is to leverage the findings to optimize aftercare services for cancer survivors within the local context of Ausl IRCCS Reggio Emilia. By incorporating the perspectives of patients, caregivers, and stakeholders, the research aims to contribute valuable insights that can inform the redesign and improvement of aftercare services, ultimately benefitting cancer survivors in the region.",[256,257,258,259,260,261,262,263],"Cancer","Breast Cancer","Prostate Cancer","Thyroid Cancer","Colorectal Cancer","Lymphoma","Multiple Myeloma","Neoplasms",[265,266,267,256,268,269,270,271,272,273,274,275],"Unmet needs","Quality of Life","Survivorship care","Survivors","Care givers","Stakeholder","Breast","Prostate","Thyroid","Colorectal","Myeloma","2024-12-04",{"date":278,"type":44},"2024-12-09",{"date":280,"type":44},"2023-04-20",{"date":282,"type":22},"2025-10",{"name":50,"class":51},{"id":285,"slug":286,"hasResults":11,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":292,"sex":293,"minAge":18,"maxAge":294,"enrollmentInfo":295,"targetDuration":4,"studyType":297,"phases":298,"briefSummary":300,"conditions":301,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":306,"startDateStruct":307,"completionDateStruct":309,"leadSponsor":311,"locationsCount":312},"100442620","fetal-growth-abnormality-detection-trial-100442620","NCT05043753","\"Fetal gRowth AbnorMality dEtection Trial\"","Department of Obstetrics and Gynecology Modena Policlinico Hospital Vial Del Pozzo 71, 41125 Modena","FRAME","Inclusion Criteria:\n\n* Maternal age ≥ 18 years and ability to give informed consent.\n* Singleton gestation\n* Ultrasound examination that confirms or revises the EDD before 14 weeks of gestational age\n* Gestational age ≥ 35 weeks' gestation\n* Normal aneuploidy screening (1st trimester screening, 2nd trimester screening, integrated screening, NIPT) when performed\n* Spontaneously conceived pregnancy (i.e the current pregnancy is not the result of in vitro fertilization)\n\nExclusion Criteria:\n\n* Fetal chromosomal or genetic abnormalities if invasive prenatal diagnosis is performed\n* Fetal malformations or soft markers identified on fetal anatomy survey\n* Episodes of uterine bleeding after 24 weeks gestation. Unobserved self-reported bleeding with confirmed intact pregnancy on ultrasound after the bleeding episode is not an exclusion criteria.\n* Uterine\u002Fplacental abnormalities including uterine malformations (i.e bicornuate uterus, didelpus uterus), abnormal placentation (placenta previa, accreta, percreta), uterine fibroids.\n* Cerclage in the current pregnancy\n* History of intrauterine fetal demise\n* History of fetal growth restriction or birth weight \\> 4Kg in a previous pregnancy\n* Fetal isoimmunization or alloimmunization\n* Fetal demise in previous pregnancies\n* Cancer (including melanoma but excluding other skin cancers). Dysplastic or pre-neoplatic conditions such as cervical intraepithelial neoplasia are admissible.\n* Endocrine disease including thyroid disease (recently diagnosed or whose medication dose is not stable), adrenal disease, diabetes mellitus (pregestational and gestational).\n* Renal disease with altered renal function (creatinine \\> 0.9, proteinuria \\> 300 mg\u002F24 hour)\n* Epilepsy or other seizure disorder\n* Any collagen disease (lupus erythematosus, scleroderma, etc.)\n* Active liver disease (acute hepatitis, chronic active hepatitis, persistently abnormal liver enzymes). Liver disorders accounting for cholestasis (including cholestasis of pregnancy) if diagnosed prior to enrollment.\n* Hematological disorder including alloimmune and isoimmune thrombocytopenia but excluding mild iron deficiency anemia (Hb \\> 9 gm\u002Fdl). Patients with sickle cell disease are excluded.\n* Chronic pulmonary disease including asthma requiring regular use of medication and active TB. An asthma inhaler used on an as needed basis for a cold or an asthma attack is not considered regular use.\n* Heart disease except mitral value prolapse not requiring medication\n* Cardiovascular disorders: chronic hypertension, gestational hypertension or preeclampsia diagnosed prior to enrollment\n* Infectious diseases: HIV, CMV, toxoplasmosis, parvovirus B19, HBV, HCV\n* Chronic treatments with medications such as aspirin, steroids, anti-hypertensive agents, immunosuppressants, antineoplastic drugs.\n* Prior laparoscopic or open uterine surgeries where the uterine cavity was entered (such as myomectomies)\n* Resectoscopic myomectomies (prior resectoscopic polypectomies are not contraindications)\n* Prior classical cesarean deliveries.",true,"FEMALE","45 Years",{"count":296,"type":22},1566,"INTERVENTIONAL",[299],"NA","The present trial intends to assess the diagnostic accuracy of symphysis fundal height (SFH) as opposed to SFH combined with point of care ultrasound to measure the fetal abdominal circumference (POC-US-AC) in identifying small and large for gestational age infants (SGA and LGA infants) among low-risk pregnant women cared for by midwives after 35 weeks' gestation.\n\nLow risk pregnancies will be evaluated at 35-38, 40, 41, and 41+ weeks' gestation by midwives trained in SFH measurement and POC-US. Formal obstetric US performed by a perinatologist (i.e high risk obstetrician) will be performed in case SFH and\u002For POC-US suspect fetal growth or amniotic fluid abnormalities. Prenatal evaluations will be compared to actual birthweights.",[302,303,304,305],"Small for Gestational Age Infant","Large for Gestational Age Infant","Oligohydramnios","Polyhydramnios",{"date":278,"type":44},{"date":308,"type":44},"2024-01-20",{"date":310,"type":22},"2025-12-21",{"name":50,"class":51},3,{"id":314,"slug":315,"hasResults":11,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":319,"eligibilityCriteria":320,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":323,"conditions":324,"keywords":328,"overallStatus":40,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":78},"100555000","rehabilitation-needs-for-hematologic-cancer-candidate-for-hematopoietic-stem-cell-transplantation-or-car-t-cell-therapy-100555000","NCT06506396","Rehabilitation Needs for Hematologic Cancer Candidate for Hematopoietic Stem Cell Transplantation or CAR T-Cell Therapy","Outcomes and Rehabilitation Needs of Patients With Hematologic Cancer Candidate for Hematopoietic Stem Cell Transplantation or CAR T-Cell Therapy: a Prospective Observational Study","HEMATOneeds","Inclusion Criteria:\n\n* Patients with hematologic cancer scheduled to undergo HSCT or CAR T-cell therapy;\n* Age ≥18 years\n* Able to provide informed consent to participate in the study\n* Able to understand and participate in the study\n* Able to understand and communicate in the Italian language\n\nExclusion Criteria:\n\n• Patients who are unable to perform physical tests or have contraindications to movement",{"count":322,"type":22},20,"Hematopoietic Stem Cell Transplantation (HSCT) and CAR T-cell therapy are effective treatments for blood cancers, extending patients lives. However, these treatments can cause side effects like muscle weakness and fatigue. Recent findings suggest these issues can significantly affect patient quality of life during CAR T-cell therapy.\n\nPatients undergoing HSCT and CAR T-cell therapy often face frequent infections and strong immune responses, requiring long periods of rest. This worsens their physical condition and impacts their quality of life, muscle strength, and fatigue levels. Minimizing these side effects is crucial to improve the well-being of patients undergoing these advanced treatments.\n\nThis study aims to assess the physical abilities (main goal) of patients preparing for HSCT or CAR T-cell therapy. It also aims to examine their quality of life and describe the symptoms and complications they may experience. The results will help identify rehabilitation needs for these patients.",[325,326,327],"Stem Cell Transplantation","Immunotherapy","CAR T-Cell Therapy",[329,330,331,332,333],"Functional Status","Quality of life","Needs Assesment","Physical Conditioning, Human","Hematologic Neoplasms","2024-07-17",{"date":336,"type":44},"2024-07-19",{"date":338,"type":22},"2024-08",{"date":340,"type":22},"2025-05",{"name":50,"class":51},{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":346,"acronym":347,"eligibilityCriteria":348,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":23,"phases":4,"briefSummary":350,"conditions":351,"keywords":352,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":360,"leadSponsor":362,"locationsCount":78},"100349206","correlation-between-trans-esophageal-pressure-and-non-invasive-respiratory-support-failure-in-patients-with-acute-hypoxic-respiratory-failure-100349206","NCT03826797","Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure","TEMPO","Inclusion Criteria:\n\n* Age \\>18 years\n* Acute hypoxic respiratory failure (P\u002FF \\\u003C 200)\n\nExclusion Criteria:\n\n* Acute pulmonary edema\n* Chest wall deformities\n* Immediate need for Mechanical Ventilation\n* Pregnancy\n* Hypercapnic RF",{"count":131,"type":22},"This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute hypoxic respiratory failure of different etiology (including COVID-19).",[110],[353,235,354],"Non invasive ventilation","Transpulmonary pressure","2023-03-22",{"date":357,"type":44},"2023-03-23",{"date":359,"type":44},"2016-10-16",{"date":361,"type":22},"2027-12-31",{"name":50,"class":51},""]