[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Nevada, Las Vegas\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":596},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,20,0,[8,45,76,106,136,168,198,225,262,296,320,347,374,409,437,469,496,527,550,570],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100548355","prosthetic-performance-enhancement-trial-100548355",false,"NCT06419920","Prosthetic Performance Enhancement Trial","PROSPER","Inclusion Criteria:\n\n* lower limb amputation at ankle (Symes) level and above\n* age 18+ years\n* fitted with a walking prosthesis and use it regularly for home and\u002For community ambulation\n* good socket fit, assessed by a score of 8-10 on the socket fit comfort scale\n* able to walk for three minutes at a time with or without an assistive device\n\nExclusion Criteria:\n\n* leg\u002Ffoot ulcer or other conditions that cause pain during weight-bearing\n* poor skin integrity that could cause tissue breakdown by walking\n* cardiovascular, respiratory or other critical health conditions that preclude moderate physical activity\n* unilateral or bilateral upper limb absence or loss at the wrist and above that precludes use of handrails bilaterally, or would require asymmetrical adaptation to body posture for use.\n* pregnancy","ALL","18 Years",{"count":19,"type":20},35,"ESTIMATED","INTERVENTIONAL",[23],"NA","The purpose of this research is to determine the feasibility of an uneven terrain walking program for lower limb prosthesis users. The training is designed to induce step-to-step variability during walking within a safe environment, with the aim of improving walking skill and confidence.",[26,27,28,29,30,31],"Amputation","Lower Limb Amputation Below Knee (Injury)","Lower Limb Amputation Above Knee (Injury)","Lower Limb Amputation at Ankle (Injury)","Lower Limb Amputation Knee","Lower Limb Amputation at Hip (Injury)","RECRUITING","2026-06-18",{"date":35,"type":36},"2026-06-23","ACTUAL",{"date":38,"type":36},"2025-06-26",{"date":40,"type":20},"2027-07",{"name":42,"class":43},"University of Nevada, Las Vegas","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":4},"100640875","occupation-based-cognitive-stimulation-with-and-without-motivational-feedback-in-parkinsons-disease-100640875","NCT07630194","Occupation-Based Cognitive Stimulation With and Without Motivational Feedback in Parkinson's Disease","Enjoyable Occupation-Based Cognitive Stimulation With and Without Motivational Feedback in Parkinson's Disease: A Randomized Controlled Trial Protocol","EOBCS","Inclusion Criteria:\n\n* (a) have idiopathic PD diagnosed according to the UK Parkinson's Disease Society Brain Bank criteria; (b) have no history of impulsive-compulsive disorders, confirmed through neurologist-led clinical interviews; (c) are classified as Hoehn and Yahr stages I-IV; (d) are aged 60-80 years; (e) demonstrate mild-to-moderate cognitive impairment, defined as a Montreal Cognitive Assessment (MoCA) score of 21-25; and (f) are able to complete self-report measures.\n\nExclusion Criteria:\n\n* atypical parkinsonian syndromes, coexisting neurological disorders (e.g., stroke, other neurodegenerative diseases), and young-onset PD","60 Years","80 Years",{"count":56,"type":20},90,[23],"Background: Cognitive impairment and psychological symptoms are highly prevalent in Parkinson's disease (PD) and significantly compromise daily functioning and quality of life. Occupation-based cognitive stimulation may enhance ecological validity and engagement, while motivational feedback could further improve adherence and neuroplasticity. However, the combined effects of these approaches have not been systematically examined in PD.\n\nObjective: To evaluate the effects of enjoyable occupation-based cognitive stimulation with and without motivational feedback on cognitive, psychological, and occupational outcomes in older adults with PD and cognitive impairment.\n\nMethods: This single-blind, three-arm randomized controlled trial will enroll 71 community-dwelling older adults with idiopathic PD. Participants will be randomly assigned to: (A) occupation-based cognitive stimulation with motivational feedback, (B) occupation-based cognitive stimulation without motivational feedback, or (C) gold standard of conventional occupational therapy. Interventions will consist of 12 supervised sessions over 6 weeks. The primary outcome is occupational performance measured by the Canadian Occupational Performance Measure (COPM). Secondary outcomes include global and Parkinson's disease-specific cognitive function (Montreal Cognitive Assessment \\[MoCA\\], Parkinson's Disease-Cognitive Rating Scale \\[PD-CRS\\], SCOPA-Cognition, Stroop Test, Clock Drawing Test, Trail Making Test), intrinsic motivation (Intrinsic Motivation Inventory), anxiety and depression (Hospital Anxiety and Depression Scale), apathy (Apathy Evaluation Scale, Lille Apathy Rating Scale, Dimensional Apathy Scale), quality of life (Parkinson's Disease Questionnaire-39), functional mobility (Timed Up and Go under single- and dual-task conditions), fear-related constructs (Tampa Scale of Kinesiophobia, Fear-Avoidance Components Scale, Falls Efficacy Scale-International), and flow experience during activities (Flow Short Scale and related occupational and rehabilitation flow measures). Assessments will be conducted at baseline, post-intervention, and follow-up. Data will be analyzed using linear mixed-effects models under an intention-to-treat framework.\n\nDiscussion: This trial will clarify the additive value of motivational feedback in occupation-based cognitive rehabilitation for PD. Findings may inform client-centered, ecologically valid rehabilitation strategies targeting non-motor symptoms in PD.",[60],"Parkinsons Disease With Mild to Moderate Memory and\u002For Thinking Problems",[62,63,64,65,66],"Cognition","Occupational therapy","Quality of life","Feedback","motivation","NOT_YET_RECRUITING","2026-06-01",{"date":70,"type":36},"2026-06-05",{"date":72,"type":20},"2026-07-01",{"date":74,"type":20},"2028-07-01",{"name":42,"class":43},{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":84,"enrollmentInfo":85,"targetDuration":87,"studyType":88,"phases":4,"briefSummary":89,"conditions":90,"keywords":92,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":100,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":44},"100637363","vascular-function-in-adults-with-down-syndrome-100637363","NCT07630207","Vascular Function in Adults With Down Syndrome","VDS","Inclusion Criteria:\n\n* between 18 and 35 years old\n* generally healthy\n* sedentary (defined as being involved in less than 30 minutes of moderately-intense physical activity per day)\n\nAdditionally, for the participants with Down syndrome:\n\n* diagnosis of Down syndrome trisomy 21\n* normal thyroid function or stable thyroid function (and medications) for at least 6 mo.\n\nExclusion Criteria:\n\n* unresolved congenital heart disease;\n* atherosclerotic or other vascular disease (such as blood clot history or clotting disorders);\n* asthma or other pulmonary disease;\n* hypertension (defined BP \\>140\u002F90 mmHg); blood pressure below 90\u002F60 mmHg;\n* history of pre-syncope or syncope;\n* diabetes (defined as Hba1c of \\>7.5% or use of glucose lowering medication);\n* severe obesity (defined as BMI \\>40);\n* heart medications affecting heart rate, blood pressure or arterial function, including blood thinners; anti-inflammatory medication including NSAIDS;\n* current smoking;\n* currently pregnant or planning to become pregnant during the study period;\n* currently breastfeeding;\n* unable or unwilling to use an acceptable method of contraception during the study timeframe;\n* positive pregnancy test at screening.",true,"35 Years",{"count":86,"type":20},24,"2 Days","OBSERVATIONAL","Adults with Down syndrome (Ds) are often thought to have a lower risk of heart and blood vessel disease because they tend to have lower blood pressure and fewer heart attacks than people without Ds. However, recent research suggests that heart and blood vessel diseases, including stroke, are becoming a more common cause of death in adults with Ds as life expectancy increases. Despite these findings, studies examining heart and blood vessel health in adults with Ds have produced mixed results, making it difficult to determine their true risk and whether preventive strategies are needed. This study will investigate the health of blood vessels in adults with Ds and compare the results with those of adults without Ds. Healthy blood vessels are important because they help deliver blood and oxygen throughout the body. Changes in blood vessel function and stiffness can occur with aging and may increase the risk of heart disease, stroke, kidney disease, and memory problems. The study aims to determine whether adults with Ds experience changes in blood vessel health that may place them at increased cardiovascular risk. Specifically, the study will: (1) Examine how well blood vessels function in adults with Ds; (2) Measure the stiffness of arteries in adults with Ds; (3) Compare two methods used to assess blood vessel function to determine whether a simpler exercise-based test provides results similar to a commonly used standard test.\n\nThe findings may improve understanding of cardiovascular risk in adults with Ds and help guide future strategies to promote healthy aging in this population.",[91],"Down Syndrome (Trisomy 21)",[93,94,95,96,97,98,99],"Down Syndrome","Trisomy 21","Arterial stiffness","Endothelial function","vascular function","ultrasonography","arterial doppler",{"date":70,"type":36},{"date":102,"type":36},"2026-04-09",{"date":104,"type":20},"2026-12-31",{"name":42,"class":43},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":110,"acronym":4,"eligibilityCriteria":111,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":112,"enrollmentInfo":113,"targetDuration":115,"studyType":88,"phases":4,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":44},"100594529","assessment-of-stroke-volume-in-shock-using-echocardiography-versus-bioreactive-impedance-100594529","NCT07020637","Assessment of Stroke Volume in Shock Using Echocardiography Versus Bioreactive Impedance","Inclusion Criteria\n\n* Age ≥ 18 years\n* Clinical diagnosis of shock as determined by the treating ICU physician (e.g., hypotension requiring vasopressors or evidence of end-organ hypoperfusion)\n* Able to obtain informed consent from the patient or a legally authorized representative\n* Enrollment within 24 hours of ICU admission\n\nExclusion Criteria:\n\n* Pregnancy\n* Known severe aortic valve disease or dynamic left ventricular outflow tract obstruction\n* Morbid obesity (BMI \\> 40) that precludes accurate echocardiographic imaging Presence of cardiac arrhythmias (e.g., atrial fibrillation with rapid ventricular response) affecting stroke volume measurements\n* Implanted cardiac assist devices (e.g., LVAD, pacemaker dependency)\n* Imminent death or decision for comfort care only","90 Years",{"count":114,"type":20},30,"1 Day","This study aims to evaluate the correlation between stroke volume measurements obtained by transthoracic echocardiography and bioreactance-based noninvasive cardiac output monitoring. The primary objective is to assess the level of agreement between these two modalities in critically ill patients.",[118,119],"Shock","Critical Illness",[121,122,123,124,125,126,127],"Cheeta NICOM","Bioreactance","Transthoracic Echocardiography","Passive Leg Raising","Stroke Volume","Shock Assssment","Noninvasive Cardiac Output Monitoring","2026-04-13",{"date":130,"type":36},"2026-04-15",{"date":132,"type":36},"2024-10-19",{"date":134,"type":20},"2026-04-30",{"name":42,"class":43},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":140,"acronym":141,"eligibilityCriteria":142,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":143,"targetDuration":4,"studyType":21,"phases":145,"briefSummary":146,"conditions":147,"keywords":152,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":4},"100632798","sleep-optimization-to-aid-in-recovery-digital-program-100632798","NCT07518368","Sleep Optimization to Aid in Recovery Digital Program","SOARPilot","Inclusion Criteria:\n\n* 18 years or older,\n* Initiating treatment for an eating disorder (e.g., currently on a waitlist for eating disorder treatment, scheduled to start treatment, completed an intake, or started treatment within the past two weeks for an eating disorder),\n* Able to access the internet\n\nExclusion Criteria:\n\n* None",{"count":144,"type":20},154,[23],"The purpose of this pilot study is to evaluate the usability and feasibility of SOAR (Sleep Optimization to Aid Recovery), a brief and self-guided digital program designed to share evidence-based sleep hygiene information with individuals seeking treatment for an eating disorder. The SOAR program delivers well-established recommendations promoted by the National Sleep Foundation and other professional sleep health organizations. The purpose of this study is not to test a new treatment or intervention per se, but rather to examine how effectively this existing information can be delivered through a digital platform to people preparing for or engaged in eating disorder treatment. By providing these evidence-based strategies in a user-friendly and accessible format, SOAR aims to support healthy sleep habits that may enhance overall well-being and facilitate recovery.\n\nThe investigators will compare SOAR against a control condition, which would be no intervention (treatment-as-usual). Participants randomized to the control will receive access to SOAR after the follow-up period has ended, if they wish to use it.",[148,149,150,151],"Sleep Health","Binge Eating","Disordered Eating","Sleep Disturbances",[153,154,155,156,157,158,159],"Eating disorders","Disordered eating","Binge eating","Sleep health","Sleep disturbances","waitlist","eating disorder treatment","2026-04-06",{"date":162,"type":36},"2026-04-08",{"date":164,"type":20},"2026-05",{"date":166,"type":20},"2028-03",{"name":42,"class":43},{"id":169,"slug":170,"hasResults":11,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":83,"sex":16,"minAge":175,"maxAge":176,"enrollmentInfo":177,"targetDuration":4,"studyType":21,"phases":179,"briefSummary":180,"conditions":181,"keywords":185,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":44},"100575361","problem-behavior-assessment-and-intervention-in-idea-part-c-services-100575361","NCT06771284","Problem Behavior Assessment and Intervention in IDEA Part C Services","Problem Behavior Assessment and Intervention in IDEA Part C Services: A Single-Case Study","Child Inclusion Criteria:\n\n* age birth to 5 years old\n* has a developmental disability or delay based on caregiver report and\u002For receiving early intervention services\n* has problem behavior, as reported by the caregiver and\u002For early intervention professional\n\nCaregivers (e.g., parent, grandparent) of eligible child participants will participate with their child as the implementer of all procedures.\n\nAn early intervention professional will participate with each caregiver-child dyad to coach the caregiver, in addition to the researcher.","0 Months","5 Years",{"count":178,"type":20},9,[23],"The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services. The investigators will conduct a single-case study to evaluate the efficacy of the intervention.",[182,183,184],"Problem Behavior","Developmental Delay","Developmental Disability",[186,187,188,189],"Early childhood","Problem behavior","Home-based services","IDEA Part C services","2026-01-20",{"date":192,"type":36},"2026-01-22",{"date":194,"type":36},"2025-09-30",{"date":196,"type":20},"2027-05",{"name":42,"class":43},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":204,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":206,"minAge":17,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":21,"phases":209,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":221,"leadSponsor":223,"locationsCount":224},"100515310","phase-1-mitigating-ptsd-cud-after-sexual-assault-100515310","NCT05989841","Mitigating PTSD-CUD After Sexual Assault","Mitigating PTSD-CUD Among Women Presenting to Emergency Care After Sexual Assault: Testing a Digital Therapeutic Targeting Anxiety Sensitivity","RISE-C","Inclusion Criteria:\n\n1. Women sexual assault survivors presenting for emergency care \\\u003C72 hours post-assault at 1 of our 4 emergency care sites\n2. English speakers\n3. 18+ years of age\n4. Able to provide informed consent\n5. Have a smartphone with continuous service \\>1 year\n6. Report \\>1x\u002Fweekly cannabis use on a substance use screener\n7. Report elevated AS (\\>17 on the Anxiety Sensitivity Index-3)\n\nExclusion Criteria:\n\n1. Inability to provide informed consent (e.g., serious injury preventing the ability to hear, speak, or see to consent and participate, or other causes (e.g., diagnosed cognitive deficits, diagnosed dementia, asleep at time of screening)).\n2. Prisoner\n3. Currently pregnant\n4. Lives with assailant and plans to continue to do so\n5. Admitted patient\n6. No mailing address\n7. Previously enrolled\n8. No sexual assault nurse examiner (SANE) examination\n9. Reporting current plan and intent for suicide or homicide\n10. Does not understand written and spoken English","FEMALE",{"count":208,"type":20},68,[210,211],"PHASE1","PHASE2","683,000 women are sexually assaulted annually in the United States, half of whom develop chronic posttraumatic stress disorder (PTSD) and thus have markedly increased risk for cannabis use disorder (CUD). The current proposal will test the acceptability, initial efficacy, and mechanisms underlying a novel digital therapeutic targeting risk for PTSD-CUD, which could address the critical need for PTSD-CUD prevention for the 100,000 women who annually present for emergency care after sexual assault. In this research context, the applicant will receive key training in multisite, emergency-care based randomized clinical trials (RCTs), advanced statistical analyses for RCTs and ecological momentary assessment data, biobehavioral mechanisms underlying PTSD-CUD prevention, and professional development, launching her independent research career focused on reducing the public health burden of PTSD-CUD among sexual assault survivors by leveraging digital therapeutics.",[214,215],"Posttraumatic Stress Disorder","Cannabis Use Disorder","2026-01-14",{"date":218,"type":36},"2026-01-16",{"date":220,"type":36},"2024-03-14",{"date":222,"type":20},"2028-02-29",{"name":42,"class":43},6,{"id":226,"slug":227,"hasResults":11,"nctId":228,"briefTitle":229,"officialTitle":230,"acronym":231,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":233,"enrollmentInfo":234,"targetDuration":4,"studyType":21,"phases":235,"briefSummary":236,"conditions":237,"keywords":249,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":255,"lastUpdatePostDateStruct":256,"startDateStruct":258,"completionDateStruct":260,"leadSponsor":261,"locationsCount":44},"100599273","feasibility-and-potential-efficacy-of-herbs-and-spices-for-improving-dietary-quality-in-college-students-a-pilot-study-100599273","NCT07082348","Feasibility and Potential Efficacy of Herbs and Spices for Improving Dietary Quality in College Students: A Pilot Study","Assessing the Feasibility and Potential Efficacy of Herbs and Spices for Improving Dietary Quality and Adherence to the Dietary Guidelines for Americans in College Students With Poor Dietary Quality: A Pilot Study","HerbSpicesDiet","Inclusion Criteria:\n\n* College students (undergraduate and graduate)\n* Ages 18-39 years\n* BMI 18.5-40 kg\u002Fm\n* Having poor dietary quality (a Rapid Prime Diet Quality Score of 12 or below),\n* Maintain current lifestyle habits (e.g., medications\u002F supplement use, exercise, and sleep), and avoid taking new supplements or medications throughout the study.\n\nExclusion Criteria:\n\n* Individuals diagnosed with myocardial infarction within the past 6 months\n* Uncontrolled hypertension\n* BMIs \\\u003C18.5 or \\>40 kg\u002Fm2\n* Autoimmune disease or immune compromised\n* A recent diagnosis of cancer or under current treatment for cancer\n* A history of kidney stones\n* Having pacemaker\n* Participating in a weight loss program\n* Having a history of any significant GI disease\n* Insulin use\n* Currently on dialysis\n* Currently consuming pro-\u002Fpre-biotics or antiobiotics\n* Diagnosed with unstable chronic metabolic disease\n* Have allergies to any herbs and spices\n* Are pregnant\u002Fnursing\n* Participating in another investigational study\n* Unable or unwilling to give consent","39 Years",{"count":114,"type":20},[23],"The goal of this single-arm feasibility, pilot study is to assess the feasibility, acceptability, and potential effectiveness of the Herbs and Spices Nutrition Education Program (HSNP-focusing on incorporating herbs and spices into the diet for adherence to the DGA's) for determining the scalability of implementing this intervention for a larger scale, more comprehensive study The main questions it aims to answer are:\n\n* What is the feasibility and acceptability of incorporating herbs and spices into the diet along with DGA-focused nutrition education through the HSNP in college students with poor dietary quality?\n* What are the preliminary effects of the HSNP on dietary intake\u002Fquality, cardiometabolic, and gut health in college students with poor dietary quality?\n* What are the barriers associated with HSNP implementation in college students with poor dietary quality?\n\nParticipants will:\n\n* Be asked to come to the study site initially for a Screening Study Visit to confirm eligibility.\n* Be asked to come the clinical study site for a Pre-HSNP and Post-HSNP Study Visit (one week prior starting the HSNP and after week 6 of completing the HSNP) for assessments of cardiometabolic and gut health.\n* Be asked to come to the Nutrition Center for weeks 0 and 3 of the HSNP, where they will receive education on the Dietary Guidelines for Americans and the health benefits of herbs and spices, have a sensory evaluation of foods, be provided budget-friendly recipes and resources, and given take-home herbs, spices, and supporting materials\n* Be asked to complete 3-Day Food Records throughout the 6 week study period for assessment of dietary quality (4 total)",[238,239,240,241,242,243,244,245,246,247,248],"Dietary Quality","Feasibility Studies","College Student","Dietary Guidelines for Americans","Gut Microbiome","Lipid Profiles","Herbs and Spices","Acceptability","Inflammation Biomarkers","Body Composition","Anthropometrics",[250,251,252,253,254],"dietary quality","dietary guidelines for americans","college students","cardiometabolic health","gut microbiome","2025-11-18",{"date":257,"type":36},"2025-11-24",{"date":259,"type":36},"2025-07-03",{"date":104,"type":20},{"name":42,"class":43},{"id":263,"slug":264,"hasResults":11,"nctId":265,"briefTitle":266,"officialTitle":267,"acronym":268,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":16,"minAge":270,"maxAge":54,"enrollmentInfo":271,"targetDuration":4,"studyType":21,"phases":273,"briefSummary":274,"conditions":275,"keywords":284,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":294,"locationsCount":295},"100578896","how-a-mediterranean-diet-with-potatoes-impacts-heart-and-metabolic-health-in-adults-with-pre-diabetes-100578896","NCT06817252","How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-Diabetes","Effects of a Mediterranean Dietary Pattern With White Potato on Cardiometabolic Health in Adults With Pre-Diabetes","MEDPOT-PREDM","Inclusion Criteria:\n\n* Men and postmenopausal women within the Las Vegas\u002FHenderson NV area\n* Ages 45-80 years\n* BMI between 25-40 kg\u002Fm2\n* HbA1c between 5.7-6.4%\n* Individuals from different demographic backgrounds (i.e., American Indian or Alaska Native, Caucasians, Asian, Black or African-American, Native Hawaiian, Hispanic, Latino or Pacific Islander)\n* Individuals who are considered \"non-frequent\" white potato consumers (\\\u003C2 servings of baked potatoes\u002Fweek)\n* Individuals from all races, genders, sexual identities, and religions will be included\n* Individuals must follow certain guidelines, including avoiding new medications during the study or significant changes to lifestyle factors (e.g. beginning to smoke or exercise more or less than usual)\n\nExclusion Criteria:\n\n* Individuals with uncontrolled hypertension (≥160\u002F100mmHg), active cancer, asthma, thyroid, kidney, liver, or pancreatic diseases\n* Individuals who are currently using insulin, on dialysis, changing\u002Fadding hypoglycemic, anti-hypertensive, and hypocholesterolemic medication within ≤3 months (or throughout the study)\n* Individuals participating in weight loss programs or another clinical trial\n* Individuals who start smoking\n* Individuals who have unstable metabolic or chronic diseases\n* Individuals who may have allergies to potatoes\n* Woman who are currently pregnant, think they may be pregnant, or who is nursing cannot participate (women must be postmenopausal)","45 Years",{"count":272,"type":20},60,[23],"The goal of this clinical trial is to is to determine the effects of baked potato with the skin (BP) + nutrition education focused on adherence for a Mediterranean Dietary Pattern (MEDNE) on glycemic control, cardiometabolic health, and dietary quality in individuals with pre-diabetes from different demographic backgrounds. The main questions it aims to answer are:\n\n* Does BP+MEDNE contribute to improvements in indices of glycemic control, vascular function, blood lipids, inflammation\u002Foxidative stress, and body composition?\n* Does BP+MEDNE contribute to improvements to overall dietary intake and quality?\n\nResearchers will compare BP+MEDNE to MEDNE alone to see if BP+MEDNE can improve glycemic control, cardiometabolic health, and dietary quality in individuals with pre-diabetes from different demographic backgrounds.\n\nParticipants will:\n\n* Be asked to come to the study site initially for a Screening Study Visit to confirm eligibility.\n* Be asked to come the study site for a Pre-Baseline and Pre-12-Week Study Visit (one week prior to Baseline and 12-Week Study Visits) for placement of placement of a continuous glucose monitor and wearable devices to be removed at Baseline and 12-Week Study Visits.\n* Be asked to come to the study site for Baseline, 6- and 12-Week Study Visits for assessments of glycemic control and cardiometabolic health.\n* Be asked to complete 3-Day Food Records throughout the 12 week study period for assessment of dietary quality (5 total)\n* Receive pre-recorded MEDNE ( which can be accessed via computer device\u002Fipad\u002Fsmartphone) after Baseline and 6-Week Study Visits.\n* If randomized to the BP+MEDNE group, participants will receive pre-prepared baked potatoes with the skin for the 12-week study period (every 3 weeks) at Baseline and 6-Week Study Visits and asked to come to the study site for picking up the pre-prepared baked potatoes at weeks 3 and 9 of the study period.",[276,277,278,279,280,246,238,281,282,283],"Prediabetes","Lipid Profile","Hypertension","Glycemic Control","Arterial Stiffness, Blood Pressure","Body Composition Measurement","Waist Circumference","Anthropometrics: Height and Weight",[285,276,286,287,238],"White Potato","Mediterranean Diet","Cardiometabolic Health","2025-11-17",{"date":290,"type":36},"2025-11-20",{"date":292,"type":36},"2025-04-24",{"date":104,"type":20},{"name":42,"class":43},2,{"id":297,"slug":298,"hasResults":11,"nctId":299,"briefTitle":300,"officialTitle":301,"acronym":4,"eligibilityCriteria":302,"healthyVolunteers":11,"sex":16,"minAge":303,"maxAge":304,"enrollmentInfo":305,"targetDuration":4,"studyType":21,"phases":307,"briefSummary":308,"conditions":309,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":313,"lastUpdatePostDateStruct":314,"startDateStruct":316,"completionDateStruct":318,"leadSponsor":319,"locationsCount":44},"100579735","dietary-wild-blueberries-and-joint-health-100579735","NCT06828159","Dietary Wild Blueberries and Joint Health","Effects of Dietary Wild Blueberries on Gut Health and Inflammation and Joint Pain","Inclusion Criteria:\n\n* Adults with documented multi-joint\u002Fknee arthritis\n\nExclusion Criteria:\n\n* inability to give informed consent\n* pregnancy or lactation\n* planned knee replacement surgery\n* allergy or contraindication to berries\n* recent trauma of the knee responsible of the symptomatic knee\n* intra-articular injection in the target knee\u002Fhip in the last 3 months\n* oral corticosteroid therapy ≥ 5 mg\u002Fday (prednisone equivalent) at baseline\n* use of berry extracts in the last 3 months\n* special diets\n* cancer treatment\n* bone diseases","40 Years","75 Years",{"count":306,"type":20},50,[23],"The goal of this proposed study is to examine the effects of dietary wild blueberries on gut microbiome, serum markers of inflammation, and joint function in adults. Each participant will consume 25g freeze-dried blueberries or matched placebo powder for 12 weeks, with a 2-week washout phase between.",[310,246,311,312],"Gut -Microbiota","Pain Assessment","Joint Pain","2025-11-03",{"date":315,"type":36},"2025-11-05",{"date":317,"type":36},"2025-09-01",{"date":166,"type":20},{"name":42,"class":43},{"id":321,"slug":322,"hasResults":11,"nctId":323,"briefTitle":324,"officialTitle":325,"acronym":4,"eligibilityCriteria":326,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":327,"enrollmentInfo":328,"targetDuration":4,"studyType":21,"phases":330,"briefSummary":331,"conditions":332,"keywords":334,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":339,"lastUpdatePostDateStruct":340,"startDateStruct":342,"completionDateStruct":344,"leadSponsor":346,"locationsCount":44},"100600939","smoking-cessation-intervention-for-young-adults-using-mtm-a-randomized-controlled-trial-100600939","NCT07104006","Smoking Cessation Intervention for Young Adults Using MTM: A Randomized Controlled Trial","Development and Testing of a Smoking Cessation Intervention Using Multi-Theory Model (MTM) Among Young Adults: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Aged 18-29 years\n* Current smoker (defined as having smoked at least one cigarette daily over the past 7 days)\n* Resident of the United States\n* Able to read and understand English\n\nExclusion Criteria:\n\n* Use of non-cigarette tobacco products (e.g., vaping, smokeless tobacco)\n* Participation in any other smoking cessation program\n* Pregnant or planning to become pregnant during the study period\n* Dual or poly-substance users, including alcohol or illicit drugs.","29 Years",{"count":329,"type":20},144,[23],"The goal of this clinical trial is to evaluate whether a Multi-Theory Model (MTM)-based behavioral intervention can effectively promote smoking cessation and support behavior change in young adult cigarette smokers aged 18 to 29 in the United States. This trial focuses on whether applying theory-driven strategies such as emotional transformation, behavioral confidence, and participatory dialogue can lead to higher smoking abstinence rates and improved psychosocial outcomes compared to a standard knowledge-based smoking education control group.\n\nThe main questions it aims to answer are:\n\n* Does the intervention lead to a greater reduction in nicotine dependence scores (measured by the Fagerström Test for Nicotine Dependence \\[FTND\\]) and an increase in quit rate among young adult smokers from baseline to 12-week follow-up?\n* Does the MTM-based intervention significantly improve 7-day point prevalence abstinence (PPA) at 12 weeks compared to a knowledge-based control group?\n* Does the intervention result in significant positive changes in MTM constructs such as participatory dialogue, behavioral confidence, emotional transformation, practice for change, and changes in the physical and social environment from baseline to 12-week follow-up? Researchers will compare the MTM-based intervention group (experimental arm) to a knowledge-based smoking education control group to determine whether the theory-driven program is more effective in supporting smoking cessation and behavior change among young adult smokers.\n\nParticipants will:\n\n* Complete surveys at three time points: baseline (Week 0), post-intervention (Week 5), and follow-up (Week 12), covering demographics, smoking history, nicotine dependence (FTND), MTM constructs (via a validated 48-item scale), and self-reported quit rates.\n* Be randomly assigned to one of two groups:\n\n  o MTM-Based Intervention Group: Attend four weekly 90-minute virtual group sessions covering: Week 1: Participatory dialogue, behavioral confidence, and process evaluation Week 2: Emotional transformation, environmental restructuring, and process evaluation Week 3: Practice for change, relapse prevention, and process evaluation Week 4: Social support, reward systems, and process evaluation\n\n  o Knowledge-Based Control Group: Attend four weekly 90-minute didactic virtual sessions focused on: Smoking-related health risks Overview of FDA-approved smoking cessation tools\n* Undergo process evaluations using the RQFSM model (Reach, Quality, Fidelity, Satisfaction, and Management) at the end of the intervention to assess how well each program was delivered and perceived.\n* Have the optional opportunity for biochemical verification of smoking abstinence using exhaled carbon monoxide (CO) testing.\n\nThis trial will be conducted entirely online and follows a randomized controlled trial (RCT) design with a 1:1 group allocation ratio. A total of 144 participants (approximately 72 per group) will be recruited, accounting for an expected attrition rate of up to 50%. This sample size was chosen to ensure sufficient power to detect statistically significant differences between the two groups (effect size f = 0.25, α = 0.05, power = 0.80).\n\nAlthough the intervention will be delivered virtually, the study is affiliated with the University of Nevada, Las Vegas (UNLV), which provides IRB approval, secure data storage infrastructure, and institutional oversight (IRB Protocol #2024-453). Informed consent will be obtained electronically, and all participant data will be securely stored using encrypted Qualtrics surveys and password-protected UNLV or Google Drive servers with limited access, ensuring full confidentiality and ethical compliance.\n\nThis trial addresses a pressing public health challenge: the persistent difficulty young adults face in quitting smoking despite decades of tobacco control efforts. Young adults remain a high-risk population for relapse and are frequently underserved by conventional cessation programs. This MTM-based intervention seeks to fill this gap by targeting both behavioral and environmental barriers through structured, evidence-based strategies designed to build self-efficacy, emotional readiness, and environmental support.\n\nThe use of MTM constructs such as emotional transformation, behavioral confidence, and restructuring the physical\u002Fsocial environment is a key innovation that may enhance long-term cessation outcomes. Moreover, delivering the program virtually increases its potential for scalability and real-world application, making it a promising model for public health programs nationwide.\n\nThe findings of this clinical trial will be disseminated through peer-reviewed journal articles, national public health conferences (APHA, SOPHE etc.), and shared with stakeholders like the CDC's Office on Smoking and Health. The results may help shape future funding priorities, guide the development of policy, and inform the design of tailored interventions for smoking cessation among young adults.",[333],"Tobacco Use Disorder\u002FCigarette Smoking",[335,336,337,338],"Smoking cessation intervention","Multi-Theory Model (MTM) of Behavior Change","Young adults","Randomized controlled trial (RCT)","2025-08-05",{"date":341,"type":36},"2025-08-11",{"date":343,"type":20},"2025-11-01",{"date":345,"type":20},"2026-03-01",{"name":42,"class":43},{"id":348,"slug":349,"hasResults":11,"nctId":350,"briefTitle":351,"officialTitle":352,"acronym":4,"eligibilityCriteria":353,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":354,"targetDuration":4,"studyType":21,"phases":356,"briefSummary":358,"conditions":359,"keywords":363,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":371,"leadSponsor":373,"locationsCount":44},"100539863","phase-4-ostomy-primary-closure-with-01-betainepolyhexanide-wound-irrigation-compared-to-pursestring-closure-100539863","NCT06309368","Ostomy Primary Closure With 0.1% Betaine\u002FPolyhexanide Wound Irrigation Compared to Pursestring Closure","To Close or Not to Close: Surgical Site Infection Rates in Ostomy Primary Closure With 0.1% Betaine\u002FPolyhexanide Wound Irrigation Compared to Conventional Ostomy Closure by Secondary Intention","Inclusion Criteria:\n\n* All patients 18 years or older with an diverting loop ileostomy reversal indication will be enrolled\n* Signed consent\n\nExclusion Criteria:\n\n* Under 18 years old, unable to provide consent, has a parastomal hernia requiring mesh repair, or has an end ileostomy",{"count":355,"type":20},84,[357],"PHASE4","The goal of this clinical trial is to compare two types of closure in patients with ostomies that are ready for closure. The main questions it aims to answer are:\n\n1. Surgical site infection rates\n2. Patient quality of life\n3. Time to wound healing\n\nParticipants will undergo either complete ostomy wound closure after washing out the wound with Prontosan, or their ostomy wound will be closed using the Pursestring method, where the wound will be left partially open and allowed to heal from the inside out. Researchers will compare these two groups' outcomes (questions to be answered) as listed above.",[360,361,362],"Surgical Site Infection","Wound Surgical","Colorectal Disorders",[364,360,365,366],"Ostomy","Primary Closure","Secondary Closure","2025-05-27",{"date":369,"type":36},"2025-06-02",{"date":220,"type":36},{"date":372,"type":20},"2029-12",{"name":42,"class":43},{"id":375,"slug":376,"hasResults":11,"nctId":377,"briefTitle":378,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":83,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":381,"targetDuration":4,"studyType":21,"phases":383,"briefSummary":384,"conditions":385,"keywords":387,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":401,"lastUpdatePostDateStruct":402,"startDateStruct":404,"completionDateStruct":406,"leadSponsor":408,"locationsCount":44},"100576152","ergonomic-protocol-for-competitive-e-sport-athletes-100576152","NCT06781580","Ergonomic Protocol for Competitive E-Sport Athletes","The Effectiveness of an Ergonomic Protocol in Reducing Ergonomic Risk and Improving Performance for Competitive E-Sport Athletes","Inclusion Criteria:\n\n* 18+ years old\n* Primarily participates in PC games(s) using mouse and keyboard for at least a year\n* Plays at least 10 hours a week\n* Must be affiliated with an established Esports team or organization\n* Must have transportation\n\nExclusion Criteria:\n\n* Individuals currently receiving treatment for self-reported pain related to prolonged gaming\n* Those with a history of surgical procedures in the upper extremities\n* Individuals with cognitive impairments\n* Individuals with a history of a neck, shoulder, wrist, and\u002For back injury",{"count":382,"type":20},12,[23],"The goal of this clinical trial is to learn if this ergonomic protocol can improve performance and reduce ergonomic risk in esports athletes. It will also learn about the insight of esports athletes and their experience in implementing this new protocol. The main questions it aims to answer are:\n\nDoes this ergonomic protocol improve performance? Does this ergonomic protocol reduce ergonomic risk?\n\nResearchers will assign the protocol to esports athletes who meet inclusion criteria and express interest in participating in the study. A pre-post design will be conducted to note any differences.\n\nParticipants will:\n\n* Participate in a 6-week study with 4 in-person visits\n* Volunteers will be requested to participate in a focus group during Week 6.\n* Implement the strengthening protocol 3x a week and a warm up\u002Fcool down protocol before and after each gaming session.\n* Attend one educational session about gaming ergonomics during Week 1\n* Complete the Rapid Entire Body Assessment, Kovaaks Asessment, and a Questionnaire during Week Zero, Week 3, and Week 6.",[386],"No Disease or Condition is Being Studied",[388,389,390,391,392,393,394,395,396,397,398,399,400],"Ergonomics","Esports athletes","Gamers","Gaming","Ergonomic protocol","Musculoskeletal disorders","Ergonomic risk","Performance","Repetitive strain injuries","Accuracy","Aim","Postural rehabilitation","Esports","2025-02-26",{"date":403,"type":36},"2025-02-27",{"date":405,"type":36},"2025-02-01",{"date":407,"type":20},"2025-04",{"name":42,"class":43},{"id":410,"slug":411,"hasResults":11,"nctId":412,"briefTitle":413,"officialTitle":414,"acronym":4,"eligibilityCriteria":415,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":416,"targetDuration":4,"studyType":21,"phases":417,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":429,"lastUpdatePostDateStruct":430,"startDateStruct":432,"completionDateStruct":434,"leadSponsor":436,"locationsCount":44},"100574267","efficacy-of-red-kinesiology-tape-on-carpal-tunnel-like-symptoms-and-performance-in-esports-gamers-100574267","NCT06757062","Efficacy of Red Kinesiology Tape on Carpal Tunnel-Like Symptoms and Performance in Esports Gamers","Less Pain, More Game: Efficacy of Red Kinesiology Tape on Carpal Tunnel-Like Symptoms and Performance in Esports Gamers","Inclusion Criteria:\n\n* over 18 years old\n* can see color vision\n* reports having numbness, tingling, weakness, or pain in the hands, wrist, or fingers\n* has a positive Phalen's test result\n* passes Ishihara Color Vision Test with a score of at least 12\n* provides written consent\n* reports to play video games over 5 hours a week on average\n\nExclusion Criteria:\n\n* cognitively impaired\n* pregnant\n* has history of skin conditions\n* has history of hand conditions other than carpal tunnel syndrome\n* has history of surgery to the wrist, hand, or fingers\n* is currently receiving other forms of physiotherapy\n* has open wounds on the kinesiology tape application site",{"count":114,"type":20},[23],"The goal of this clinical trial is to learn if dorsally applied kinesiology tape is an effective conservative treatment for symptoms of carpal tunnel syndrome and assess the potential performance effect of the tape color in first-person shooter esports games in esports gamers who exhibit symptoms that resemble carpal tunnel syndrome. The main questions it aims to answer are:\n\nIs dorsally applied kinesiology tape able to manage carpal tunnel syndrome-like symptoms in esports gamers? Does red kinesiology tape hinder or improve performance in first-person shooter esports games in esports gamers?\n\nResearchers will compare red kinesiology tape to skin tone kinesiology tape. Both will be applied on the dorsal aspect of the hand and wrist of the dominant upper extremity.\n\nParticipants will visit the site 2 times to get kinesiology tape applied and complete a pre and post-test for pain and performance. Depending on randomization a participant will receive a random sequence of the study arm (ex: red then skin tone or skin tone then red tape)",[420],"Carpal Tunnel Syndrome",[400,390,422,395,423,424,425,426,427,428],"Carapl Tunnel Syndrome","First Person Shooter","Red","Color Theory","Kinesio Tape","Kinesiology Tape","Dorsal Application","2024-12-30",{"date":431,"type":36},"2025-01-03",{"date":433,"type":20},"2025-01-01",{"date":435,"type":20},"2025-04-30",{"name":42,"class":43},{"id":438,"slug":439,"hasResults":11,"nctId":440,"briefTitle":441,"officialTitle":442,"acronym":4,"eligibilityCriteria":443,"healthyVolunteers":83,"sex":16,"minAge":444,"maxAge":4,"enrollmentInfo":445,"targetDuration":4,"studyType":21,"phases":446,"briefSummary":447,"conditions":448,"keywords":453,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":462,"lastUpdatePostDateStruct":463,"startDateStruct":465,"completionDateStruct":467,"leadSponsor":468,"locationsCount":4},"100565436","theory-based-intervention-for-promoting-responsible-gambling-among-college-students-100565436","NCT06642155","Theory-based Intervention for Promoting Responsible Gambling Among College Students","Testing the Efficacy of ResponsiblePlay©: MTM-Based Intervention for Responsible Gambling for College Students","Inclusion Criteria:\n\n* Must be at least 21 years old.\n* Must be a enrolled UNLV student.\n* Must engage in gambling activities.\n* Must have a score of 3 or higher on the Problem Gambling Severity Index (PGSI), indicating at-risk or problem gambling behavior.\n\nExclusion Criteria:\n\n* Participants currently receiving treatment for gambling disorders.\n* Individuals with cognitive impairments that would affect their ability to provide consent or participate in the intervention.\n* Individuals who are not fluent in English (since the intervention materials and assessments will be conducted in English).","21 Years",{"count":272,"type":20},[23],"The goal of this clinical trial is to learn if the RESPONSIBLEPLAY© intervention helps promote responsible gambling behaviors in University of Nevada, Las Vegas (UNLV) students aged 21 and older who have a Problem Gambling Severity Index (PGSI) score of 3 or higher. The main questions it aims to answer are:\n\nDoes the intervention reduce harmful gambling behaviors? Does the intervention increase responsible gambling practices? Researchers will compare participants receiving the RESPONSIBLEPLAY© intervention with those receiving a knowledge-based intervention to see if the RESPONSIBLEPLAY© intervention is more effective.\n\nParticipants will:\n\nAttend three face-to-face sessions on responsible gambling over three weeks. Complete surveys before, after, and eight weeks after the intervention to track their progress.",[449,450,451,452],"Problem Gambling","Pathological Gambling","Behavioral Addiction","Gambling Disorder",[454,455,449,450,456,457,458,459,460,461],"Responsible Gambling","College Students","Behavioral Interventions","Health Behavior Change","Multi-theory Model (MTM)","Randomized Controlled Trial (RCT)","Public Health Intervention","Gambling Disorder Prevention","2024-10-16",{"date":464,"type":36},"2024-10-18",{"date":466,"type":20},"2024-11",{"date":407,"type":20},{"name":42,"class":43},{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":21,"phases":477,"briefSummary":478,"conditions":479,"keywords":480,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":44},"100565172","enhancing-motor-function-in-individuals-with-lower-limb-amputation-100565172","NCT06638723","Enhancing Motor Function in Individuals with Lower Limb Amputation","Enhancing Motor Function in Individuals with Lower Limb Amputation Through Peer-Based Balance and Fall Recovery Skill Training","Inclusion Criteria:\n\n* 1\\) have unilateral lower limb amputation,\n* 2\\) age \\>18 years,\n* 3\\) are properly fitted with a walking prosthesis and use it regularly with at least moderate proficiency (K-2 level or above, further defined as scoring greater than 50 percentile on the Prosthetic Limb Users Survey of Mobility),\n* 4\\) able to stand for at least 5 minutes without using an assistive device or experiencing excessive fatigue,\n* 5\\) willing to travel to UNLV 6 times for training and testing.\n\nExclusion Criteria:\n\n* 1\\) have other concurrent central nervous system diseases that influence motor function and balance,\n* 2\\) have leg\u002Ffoot ulcer or other conditions that cause pain during weight-bearing,\n* 3\\) have cardiovascular, respiratory or other critical health conditions that preclude moderate physical activity.",{"count":5,"type":20},[23],"The overall goal of this research project is to investigate the effectiveness and the science of peer-based prosthetic skill training in individuals with leg amputation. Our belief is that amputee learners will show improved skill learning when observing demonstrations from other amputees, as opposed to observing nonamputee models. The investigators will accomplish the objective by answering the following two questions:\n\nQuestion 1: Does peer-based observation training works better for learning motor tasks for individuals with lower limb amputation (LLA)?\n\nQuestion 2: Are there differences in visual focus, behavior, and brain activation patterns when observing motor task demonstrations from amputee peers vs. non-amputees?\n\nParticipants of this study will be asked to learn a balance and a fall recovery task by observing video demonstrations by amputee peers vs. non-amputees. The investigators will compare which setting produce better learning.",[26],[481,482,483,484,485,486,487],"limb loss","peer support","motor learning","EEG","falls","balance","prosthetics","2024-10-10",{"date":490,"type":36},"2024-10-15",{"date":492,"type":36},"2023-06-30",{"date":494,"type":20},"2025-12-31",{"name":42,"class":43},{"id":497,"slug":498,"hasResults":11,"nctId":499,"briefTitle":500,"officialTitle":501,"acronym":502,"eligibilityCriteria":503,"healthyVolunteers":11,"sex":16,"minAge":504,"maxAge":505,"enrollmentInfo":506,"targetDuration":4,"studyType":21,"phases":507,"briefSummary":508,"conditions":509,"keywords":511,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":519,"lastUpdatePostDateStruct":520,"startDateStruct":522,"completionDateStruct":524,"leadSponsor":526,"locationsCount":44},"100562593","10000-step-club-community-walking-program-for-people-with-parkinsons-disease-100562593","NCT06605183","10,000 Step Club: Community Walking Program for People with Parkinson's Disease","10,000 STEP CLUB: Community Walking Program to Decrease Sedentary Behavior, Fear of Falling Avoidance Behavior, Loneliness, and Social Isolation in Parkinson's Disease","(10KSC)","Inclusion Criteria:\n\n* 30-85 years old\n* Neurologist-diagnosed Parkinson\\'s disease\n* Able to walk independently with or without a walking aid (e.g., cane, walker)\n* Willing to participate in a 6-month study\n\nExclusion Criteria:\n\n* Health diagnosis that would limit exercise participation (e.g., heart problems, uncontrolled blood pressure, exercise-induced asthma).\n* Dementia. This will be determined by completing the Montreal Cognitive Assessment\n* Participants with poor walking ability (determined using the Timed Up and Go Test during initial testing).","30 Years","85 Years",{"count":272,"type":20},[23],"The 10,000 Step Club (10KSTC) is a 6-month community walking program for people with Parkinson's disease (PwP) and their caregivers in Las Vegas, Nevada (LV). This program will consist of several weekly, organized walking groups in local parks throughout the LV Valley. Participants in the program will use Nordic walking poles during the walks. Each walking group will meet once per week at a local park and will be supervised by walking group leaders from the University of Nevada, Las Vegas. There will be three walking programs throughout the Las Vegas valley. Participants will be given a step watch to wear step counts will be tracked in real-time. The program is designed to get PwP out of their homes, cultivate a culture of connection with others with Parkinson's disease (PD), and to be collectively accountable for a common goal toward 10,000 steps per day.",[510],"Parkinson Disease",[512,513,514,515,516,517,518],"Exercise","Nordic walking","physical activity","social isolation","loneliness","fear of falling","walking","2024-09-17",{"date":521,"type":36},"2024-09-20",{"date":523,"type":36},"2024-09-11",{"date":525,"type":20},"2025-12-20",{"name":42,"class":43},{"id":528,"slug":529,"hasResults":11,"nctId":530,"briefTitle":531,"officialTitle":532,"acronym":533,"eligibilityCriteria":534,"healthyVolunteers":83,"sex":16,"minAge":504,"maxAge":505,"enrollmentInfo":535,"targetDuration":4,"studyType":21,"phases":536,"briefSummary":537,"conditions":538,"keywords":539,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":543,"lastUpdatePostDateStruct":544,"startDateStruct":546,"completionDateStruct":547,"leadSponsor":549,"locationsCount":44},"100504914","exercise-neuroprotection-in-parkinsons-disease-100504914","NCT05854524","Exercise Neuroprotection in Parkinson's Disease","Exploring the Biological Basis for Exercise Neuroprotection in Parkinson's Disease","PDex","Inclusion criteria for PwP:\n\n* 30-85 years old\n* Neurologist-diagnosed PD\n* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.\n\nInclusion criteria for controls:\n\n* 30-85 years old\n* No major medical diagnoses\n* Able to participate in 30 minutes of continuous moderate aerobic exercise with 2-3 short breaks per self-report.\n\nExclusion Criteria for both PD group and controls:\n\n* Diagnoses, identified by self-report, that would preclude exercise participation (e.g., heart arrhythmias, uncontrolled blood pressure, exercise-induced asthma).\n* Those not deemed ready for exercise participation. Participants will be screened for exercise participation using the Physical Activities Readiness Questionnaire + which is used as a screening tool for all ages to identify risk factors that would clear someone for participation in moderate physical exercise.\n* Those with dementia will be excluded because there are self-report questionnaires in this study. This will be identified using the Montreal Cognitive Assessment and a score at or below a 21. Participants with mild cognitive impairment and no impairment will be included.",{"count":56,"type":20},[23],"The purpose of this study is to explore the relationships of exercise on inflammation in the body of older adults and people with Parkinson's disease (PD). This is important research for older adults but is especially important for people with PD because neuroinflammation is the main pathological mechanism that is responsible for neuron cell death in this neurodegenerative disease. As PD is a progressive disease, halting or slowing the degeneration is an important research target. Halting or slowing the disease progress is known as neuroprotection. Exercise is an attractive therapeutic treatment for people with PD as it has a lot of multi-systemic benefits, but also there is a lot of evidence to suggest that it helps improve symptoms and slow the progression of the disease. Exercise has been theorized to decrease inflammation and, therefore, has a lot of promise as a neuroprotective agent in slowing or halting the degeneration in PD. Unfortunately, there is not a lot of research that has looked into the effect of exercise on the biological processes of inflammation. Thus, the purpose of this study is to investigate the biological evidence that underlies the positive effect of exercise in people with PD.",[510],[512,540,541,542],"Inflammation","Physical activity","Neuroprotection","2024-08-29",{"date":545,"type":36},"2024-09-03",{"date":543,"type":36},{"date":548,"type":20},"2026-12-30",{"name":42,"class":43},{"id":551,"slug":552,"hasResults":11,"nctId":553,"briefTitle":554,"officialTitle":555,"acronym":4,"eligibilityCriteria":556,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":270,"enrollmentInfo":557,"targetDuration":4,"studyType":21,"phases":558,"briefSummary":559,"conditions":560,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":562,"lastUpdatePostDateStruct":563,"startDateStruct":565,"completionDateStruct":567,"leadSponsor":569,"locationsCount":44},"100559545","modulating-cortical-excitability-to-improve-functional-movements-in-individuals-with-patellofemoral-pain-100559545","NCT06565520","Modulating Cortical Excitability to Improve Functional Movements in Individuals With Patellofemoral Pain","Modulating Cortical Excitability to Improve Functional Movements in Individuals With Patellofemoral Pain: a Randomized Control Trial","Inclusion Criteria:\n\n1. are between 18 and 45 years old\n2. have had patellofemoral pain (PFP; kneecap pain) on one side for at least 3 months, and 3) the knee does cave in when performing functional movements.\n\nExclusion Criteria:\n\n1. do not have pain coming from the kneecap during screening;\n2. have a history of knee injury or surgery,\n3. have a history of seizures and\u002For taking anti-seizure medication,\n4. have an implanted device that interacts with electric current,\n5. have a history of balance disorder,\n6. currently are pregnant or think they may be pregnant.",{"count":306,"type":20},[23],"This study sought to investigate whether modulation of cortical excitability of the gluteal musculature, via tDCS paired with exercise, will reduce the amount the knee caves in during functional tasks in individuals with PFP. The objective is the explore if having tDCS target the area of the brain controlling hip muscles, when paired with exercise, will be more effective in reducing the amount the knee caves in for individuals with PFP versus those who receive exercise alone as their treatment. The aim is to contribute our findings to the growing knowledge in this area in order to help establish the possibility, and feasibility, of its use in clinical settings to strengthen traditional treatments for this patient population.",[561],"Patellofemoral Pain Syndrome","2024-08-19",{"date":564,"type":36},"2024-08-22",{"date":566,"type":36},"2024-04-24",{"date":568,"type":20},"2025-04-21",{"name":42,"class":43},{"id":571,"slug":572,"hasResults":11,"nctId":573,"briefTitle":574,"officialTitle":575,"acronym":4,"eligibilityCriteria":576,"healthyVolunteers":11,"sex":16,"minAge":53,"maxAge":4,"enrollmentInfo":577,"targetDuration":4,"studyType":21,"phases":578,"briefSummary":579,"conditions":580,"keywords":585,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":588,"lastUpdatePostDateStruct":589,"startDateStruct":591,"completionDateStruct":593,"leadSponsor":595,"locationsCount":44},"100466659","engage-for-late-life-depression-and-comorbid-executive-dysfunction-100466659","NCT05356611","Engage for Late-Life Depression and Comorbid Executive Dysfunction","Engage: A Treatment for Late-Life Depression and Comorbid Executive\u002FCognitive Dysfunction","Inclusion Criteria:\n\n* Age 60 or older\n* Ability to read, write, and speak English\n* Located in Las Vegas or surrounding area\n* Ability to travel to UNLV campus by self or possible caregiver for regular study visits\n* Clinically significant symptoms of depression as evidenced by: 1) Scores \\> 5 on the Geriatric Depression Scale-Short Form (GDS-SF)\n* Mild cognitive impairment as evidenced by: 1) Scores \\> 18 and \\\u003C 25 on the Montreal Cognitive Assessment (MoCA)\n\nExclusion Criteria:\n\n* Active suicidal ideation\n* History of suicide attempt(s)\n* Current symptoms of: 1) Psychosis; 2) Active substance use disorder\n* Reported history of: 1) Bipolar disorder (\"manic depression\"); 2) Intellectual disability\n* Currently in or scheduled to initiate individual psychotherapy to avoid treatment interference\n* Psychotropic medication permitted if dose was stable over the past 2 weeks\n* Currently living in an institutional setting (e.g., assisted living, inpatient, skilled nursing)\n* Presence of notable memory-specific cognitive deficits as evidenced by: scores \\\u003C 9 on the MoCA memory subscale (rendering it difficult to participate in and track\u002Frecall events for weekly psychotherapy)",{"count":5,"type":20},[23],"Although there are an increasing number of mental health treatment adaptations for older adults, there are still a number of factors to consider when making these adaptations. Cognitive decline is one such factor that places significant burden on older adults and can interfere with traditional mental health therapies. Engage is a behavioral treatment approach that has shown to be effective in treating late life depression. The investigators are testing the feasibility of Engage as a treatment method for late life depression in older adults with cognitive decline. The objective is to corroborate Engage as an alternative late life depression treatment method for a sub-population of older adults with cognitive decline. Cognitive decline poses a unique mental health treatment barrier that is often over looked in younger populations. With a relatively higher prevalence of cognitive decline in older adulthood, it is imperative that a feasible mental health treatment program that can be effective in the presence of cognitive decline.",[581,582,583,584],"Depression in Old Age","Psychotherapy","Mild Cognitive Impairment","Executive Dysfunction",[586,587],"Older Adults","Late-Life Depression","2024-08-04",{"date":590,"type":36},"2024-08-06",{"date":592,"type":36},"2023-09-24",{"date":594,"type":20},"2025-05",{"name":42,"class":43},""]