[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Oregon\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":346},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,76,107,138,162,194,223,259,281,324],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100594871","adaptation-of-the-family-check-up-online-100594871",false,"NCT07025083","Adaptation of the Family Check-Up Online","Adaptation of Family Check-Up Online in the Latinx Community to Reduce Youth Substance Use","Parent Inclusion Criteria:\n\n* being a self-identified Latinx parent or guardian of a youth age 11-14\n* speaking Spanish\n* cognitively able to complete a brief screener\n* assessments at a 6th grade reading level\n* willing to participate in an online intervention\n* willing for their child to complete confidential assessments\n\nYouth Inclusion Criteria:\n\n* being a middle school student age 11-14\n* reading at the 2nd grade level in English or Spanish\n\nExclusion Criteria:\n\n* having low concerns on the Positive Family Support screener",true,"ALL","11 Years","14 Years",{"count":21,"type":22},108,"ESTIMATED","INTERVENTIONAL",[25],"NA","Latinx people are the largest and fastest growing minority population in the U.S., yet most lack access to community responsive preventative interventions to reduce substance use among youth. Effective implementation of evidence-based interventions that can be delivered online is critical to reduce substance use and problem behaviors among ethnic populations and to scale up for broad dissemination. Adaptation to address community needs has improved parenting practices and youth outcomes beyond the original evidence-based parenting interventions, and adapted parenting programs have the potential to improve cultural socialization, which is associated with improved behavioral outcomes among Latinx youth. However, ongoing tensions in the field highlight the question of whether deep adaptations compared to surface-level adaptations (e.g., translation only) are needed. The FCU is an evidence-based parenting program that has a strong history of reducing substance abuse and externalizing symptoms (e.g., problem behaviors). A community-based participatory approach will be employed to culturally adapt the FCU Online and identify implementation strategies to improve access to and adoption of the intervention, leveraging community and resiliency-promoting assets. Promotores de salud, Spanish-speaking community health workers in an existing community-based research network will deliver the program. To reach the goals of the study, the following aims will guide this research. In Aim 1, a community advisory board of 6 parents and 6 promotores de salud will meet monthly to guide the ecological adaptation of the FCU Online modules and implementation strategies with promotores. In Aim 2, the online version of the intervention will be adapted using iterative Plan-Do-Study-Act cycles to get usability feedback from members of the community advisory board, consistent with best practices designed to adapt interventions in community settings. In Aim 3, using a Hybrid 1, mixed methods design, researchers will assess feasibility, accessibility, adoption, and potential effectiveness of the adapted intervention, FCU-L Online. The team will recruit 108 Latinx families into a 3-arm wait-list randomized control trial: n=36 in the culturally adapted FCU-L Online (e.g., deep adaptation), n=36 in the FCU Online in Spanish without adaptation (e.g., surface level adaptation), and n= 36 in a waitlist control group. Feasibility, accessibility, and adoption will be assessed according to quantitative benchmarks, and qualitative feedback will assess the barriers and facilitators of implementation. Potential effectiveness will be assessed (p \\\u003C .15), including improvement of key intervention mechanisms (parenting practices, parenting efficacy, and cultural socialization) as well as child outcomes (substance use, intentions to use, and externalizing behavior). Findings from this study will inform a Hybrid II randomized controlled implementation trial to test effectiveness while scaling up dissemination of the FCU-L Online. This research could ultimately reduce lifetime risk for substance use among Latinx youth by improving parenting practices and supporting cultural socialization.",[28],"Substance Use (Drugs, Alcohol)",[30,31,32,33,34],"adolescence","parenting","adaptation","family","substance use intent","RECRUITING","2026-06-03",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":39},"2025-12-19",{"date":43,"type":22},"2027-03-31",{"name":45,"class":46},"University of Oregon","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":16,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":75},"100538533","preventing-school-exclusion-and-opioid-misuse-effectiveness-of-the-inclusive-skill-building-learning-approach-isla-100538533","NCT06292078","Preventing School Exclusion and Opioid Misuse: Effectiveness of the Inclusive Skill-building Learning Approach (ISLA)","ISLA","Teachers: The educator sample will include all educators within each of the schools. All educators that have regular contact with students (e.g., administrators, teachers, instructional assistants, school counselors) will participate in the school-wide ISLA intervention activities. All educators at both treatment and control schools, if they consent, will provide data through an annual survey administered at three time points: in the spring prior to the first year of ISLA implementation (baseline), in the spring of the first year of ISLA implementation (post-intervention), and in the spring of the second year of ISLA implementation (follow-up).\n\n* Inclusion criteria:\n\n  \\* Staff member in either a control or intervention condition school\n* Exclusion criteria:\n\n  * None\n\nCohort Students: The student cohort sample will include all students in Grade 7 during the first year of ISLA implementation, who will be followed into Grade 8 during the second year of ISLA implementation (such that data can be collected from the end of Grade 6 to the end of Grade 8). With an average middle school size of 660 students per school, we project the cohort size to be 220 students per school, for a total of 11,880 to 13,200 students.\n\nSub-cohort Students: A random sample of 50 assenting 6th grade students (at the time of baseline data collection) per cohort per school will be selected to provide additional data, for a total of 2,700 to 3,000 students (consent will be gathered from parents\u002Fguardians). With the help of each school administrator, the research team will conduct the randomization process using each school's enrollment. School administrators will invite all 6th grade students to participate via recruitment emails to their parents\u002Fguardians. A random selection of students will be made from those parents who are consented.\n\n* Inclusion Criteria:\n\n  \\* 6th grade students in either intervention or control schools during first data collection period for each wave\n* Exclusion Criteria:\n\n  * students who cannot complete the online survey independently (e.g., require assistance beyond text-to-speech files to comprehend the items and available responses) specifically:\n  * students who cannot comprehend written or spoken English or written or spoken Spanish, or\n  * students who are eligible for alternate assessment for statewide achievement testing.","8 Years","15 Years",{"count":58,"type":22},5076,[25],"This project will test the effectiveness of the Inclusive Skill-building Learning Approach (ISLA) in reducing the use of exclusionary discipline, improving teacher practice and student outcomes, and decreasing substance misuse using a randomized controlled trial in 60 middle schools across six states.",[62,63,64,65,66],"Middle Schools","School Exclusion","School Community","Teaching Practices","Opioid and Other Substance Misuse","2026-05-19",{"date":69,"type":39},"2026-05-22",{"date":71,"type":39},"2024-04-15",{"date":73,"type":22},"2027-10-01",{"name":45,"class":46},3,{"id":77,"slug":78,"hasResults":11,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":4,"eligibilityCriteria":82,"healthyVolunteers":16,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":83,"targetDuration":4,"studyType":23,"phases":85,"briefSummary":86,"conditions":87,"keywords":93,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":99,"lastUpdatePostDateStruct":100,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":47},"100583432","sbir-sttr-family-check-up-online-100583432","NCT06876246","SBIR\u002F STTR Family Check-up Online","A Digital Health Technology to Prevent Family Violence and Improve Child Mental Health","Inclusion Criteria:\n\n* A caregiver must have a child between the ages of 11 and 14 enrolled at a participating school;\n* the caregiver must be the parent or legal guardian of the youth;\n* the caregiver must have a smartphone with text messaging capability and access to email; and\n* the youth must be identified by school providers as needing or being eligible for Tier 2 or Tier 3 supports or services.\n\nExclusion Criteria:\n\n* the caregiver is unable to read in either English or Spanish; or\n* the family is already participating in another study of the University of Oregon's Prevention Science Institute.",{"count":84,"type":22},1270,[25],"The Family Check-Up Online, a digital health intervention, was designed to improve child mental health through family-centered intervention. The Family Check-Up is grounded in over 25 years of evidence-based research and has been shown to improve child mental health and behavior including depression and conduct problems. The investigators were supported by an SBIR Phase I award (R43MH132191) to evaluate the feasibility and acceptability of the digital health product in schools and to adapt the product based on findings of that work. Findings from that project suggested the model is a good fit for schools, with school providers stating a need for family-centered interventions that target child behavior and mental health, but with few resources or evidence-based programs available. The research team received feedback that suggests the model should be evaluated as both an uncoached version and coached version, delivered with provider support. In the current project, the investigators plan to continue work in schools to develop the model for commercialization, including understanding the process for embedding the FCU Online into current student support systems and implementation factors that lead to maintenance of the model in schools. The investigators plan to conduct a hybrid type 2 effectiveness-implementation trial to evaluate the effectiveness of the FCU Online when delivered by real world providers. Thirty providers (N=600 students\u002Ffamilies) will be randomly assigned to receive training in the FCU Online coached vs. uncoached models. The research team will then evaluate outcomes including family relationships, parenting skills, and child mental health and behavior. The investigators predict that the FCU Online will improve child mental health and behavior, and will test for moderators such as provider training and child baseline risk. Findings will have implications for commercialization of the product in schools and implementation of the model in a range of different school settings.",[88,89,90,91,92],"Mental Health","Parenting Stress","Academic Achievement","Parenting Skills","Behavior Problems",[94,95,96,97,98],"digital health","implementation science","mental health","family intervention","school-based intervention","2026-04-27",{"date":101,"type":39},"2026-04-29",{"date":103,"type":39},"2025-01-20",{"date":105,"type":22},"2027-12-31",{"name":45,"class":46},{"id":108,"slug":109,"hasResults":11,"nctId":110,"briefTitle":111,"officialTitle":112,"acronym":4,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":4,"enrollmentInfo":115,"targetDuration":4,"studyType":23,"phases":117,"briefSummary":118,"conditions":119,"keywords":125,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":47},"100633641","prevent-language-delays-and-disorders-among-children-of-caregivers-with-substance-use-disorders-with-community-groups-and-individualized-services-100633641","NCT07529327","Prevent Language Delays and Disorders Among Children of Caregivers With Substance Use Disorders With Community Groups and Individualized Services","Evidence-based Intervention Enhancements to Reduce Language Delays and Disorders Among Children of Parents With Substance Use Disorders","Inclusion Criteria:\n\n1. Have a:\n\n   1. Self-reported lifetime history of substance use disorder treatment and\u002For\n   2. active substance use in the past year\n2. Be providing care for\u002Fparenting a child at least 10% of the time who is:\n\n   1. between the ages of 12-42 months\n   2. English\u002FSpanish bilingual or monolingual in English or Spanish\n   3. exposed to a third language once a week or less\n   4. not yet combining three or more words regularly\n   5. has less than 150 words in their expressive vocabulary\n3. Be able to provide consent for their target child to participate, or have a legal guardian provide consent for the child to participate\n4. Be able to speak and understand English and\u002For Spanish\n5. Be willing to attend groups once a week for six weeks at a participating site\u002Fgroup time\n6. If assigned additional services, willing to attend Zoom meetings\n7. Be 18 years of age or older\n\nExclusion Criteria:\n\n-Only one caregiver per focal child can participate in the research study. Caregivers whose participating child already has another caregiver enrolled in the research study will not be eligible to participate.","18 Years",{"count":116,"type":22},244,[25],"The goal of this clinical trial is to test ways to improve early language development among young children of parents with substance use disorder (SUD). Children of parents with SUD are at increased risk for language delays, and early supports may help prevent long-term learning challenges. This study will examine whether adding additional supports to group-based parenting intervention improves child language outcomes compared to the group intervention alone.",[120,121,122,123,124],"Language Delay","Substance Use Disorders","Language Disorders in Children","Language Development","Prevention Intervention",[126,127,128,129],"Naturalistic communication intervention","Parenting","Group based intervention","Vocabulary Acquisition","2026-04-14",{"date":132,"type":39},"2026-04-20",{"date":134,"type":39},"2026-03-10",{"date":136,"type":22},"2029-11-30",{"name":45,"class":46},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":143,"eligibilityCriteria":144,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":145,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":151,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":156,"startDateStruct":157,"completionDateStruct":159,"leadSponsor":161,"locationsCount":47},"100629204","piloting-a-learning-collaborative-for-school-based-bilingual-providers-delivering-evidence-based-interventions-100629204","NCT07471633","Piloting a Learning Collaborative for School-Based Bilingual Providers Delivering Evidence-Based Interventions","SABER","Inclusion Criteria:\n\nSchool Leader Eligibility:\n\n* (a) over 18 years old;\n* (b) district-level or school-level staff who manage and oversee operations and may have some decision-making power; district examples are superintendents and directors, and school examples are principals, vice principals, and directors.\n\nSchool Providers Eligibility:\n\n* (a) over 18 years old;\n* (b) mental health clinicians or school staff who regularly interact with newcomer students;\n* (c) bilingual in Spanish\u002FEnglish. It is important to note that at least one mental health clinician must facilitate STRONG but the co-facilitator can either be another clinician or a school staff who regularly interacts with newcomer students; example of such a school staff include English Language Development Teachers, interpreters, and equity coordinators\n\nStudent Eligibility:\n\n* (a) newcomer status (students who have migrated to a new country)\n* (b) 6th-12th grade\n* c) speaks Spanish\u002FEnglish\u002FMam\n* (d) elevated levels of mental health symptoms and\u002For functional impairment\n\nCaregiver Eligibility:\n\n* (a) over 18 years old;\n* (b) primary caregiver (e.g., biological parent; older sibling) of a newcomer student aged 10-17 who is participating in STRONG;\n* (c) able to speak in English, Spanish or Mam.\n\nExclusion Criteria:\n\n\\- For Students: Born in mainland United States",{"count":146,"type":22},70,[25],"This pilot feasibility trial is designed to evaluate an adapted Learning Collaborative (LC) as an implementation strategy to support delivery of the Supporting Transition Resilience of Newcomer Groups (STRONG) intervention in school settings serving newcomer youth. The LC will support bilingual school-based mental health providers delivering STRONG, a group-based, school-delivered behavioral intervention targeting stress, anxiety, depressive symptoms, and externalizing behaviors among newcomer middle school students. STRONG will be facilitated by bilingual providers with participating students and their caregivers completing pre- and post-intervention surveys assessing youth emotional and behavioral well-being. The primary aim is to assess the feasibility, acceptability, and appropriateness of the LC for supporting school-based implementation of STRONG, with feasibility measured by participation in LC activities and completion of implementation supports, and acceptability and appropriateness assessed through provider and leader feedback. Secondary aims include examining whether provider and school leader engagement in LC activities is associated with STRONG implementation fidelity and youth outcomes, and exploring potential mechanisms linking LC engagement to fidelity, including provider self-efficacy, leadership support, and team psychological safety. School-based providers and school leaders (e.g., principals and superintendents) will participate in LC activities focused on shared learning, collaboration, and implementation problem-solving, along with ongoing supports such as structured team support calls, Plan-Do-Study-Act (PDSA) cycles, and feedback forms during STRONG implementation cycles.",[150,88],"Acculturative Stress",[152,153,154],"implementation strategies","youth mental health","schools","NOT_YET_RECRUITING",{"date":132,"type":39},{"date":158,"type":22},"2026-06-01",{"date":160,"type":22},"2027-01-31",{"name":45,"class":46},{"id":163,"slug":164,"hasResults":11,"nctId":165,"briefTitle":166,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":169,"enrollmentInfo":170,"targetDuration":4,"studyType":23,"phases":172,"briefSummary":173,"conditions":174,"keywords":176,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":186,"lastUpdatePostDateStruct":187,"startDateStruct":189,"completionDateStruct":191,"leadSponsor":193,"locationsCount":47},"100605094","repeated-far-infrared-sauna-bathing-in-adults-with-obesity-100605094","NCT07158047","Repeated Far Infrared Sauna Bathing in Adults With Obesity","Targeting Hypertension and Insulin Resistance With Heat Therapy","Inclusion Criteria:\n\n* BMI between 30-45 kg\u002Fm2\n\nExclusion Criteria:\n\n* Diagnosed diabetes\n* Greater than stage 2 hypertension\n* Coagulopathies\n* Allergies to lidocaine\n* Medications affecting blood pressure\n* Blood clotting, and blood sugars\n* Smoker\n* Pregnant\n* Desiring to become pregnant in the near future\n* Breastfeeding\n* BMI less than 30\n* BMI greater than 45 kg\u002Fm2\n* Exercising \\> 120 min\u002Fweek\n* Taking medications (other than hormone contraceptives)\n* Not willing to stop taking medications (other than hormone contraceptives) for 24 hours before testing days","59 Years",{"count":171,"type":22},20,[25],"This is a clinical trial to determine if 30 sessions of far infrared sauna bathing can improve cardiovascular and metabolic function in adults with obesity.",[175],"Obesity (Disorder)",[177,178,179,180,181,182,183,184,185],"heat therapy","insulin resistance","arterial stiffness","blood pressure","obesity","sauna","vascular health","cardiovascular","metabolic function","2026-03-02",{"date":188,"type":39},"2026-03-04",{"date":190,"type":39},"2022-03-07",{"date":192,"type":22},"2026-07-31",{"name":45,"class":46},{"id":195,"slug":196,"hasResults":11,"nctId":197,"briefTitle":198,"officialTitle":199,"acronym":200,"eligibilityCriteria":201,"healthyVolunteers":11,"sex":17,"minAge":114,"maxAge":202,"enrollmentInfo":203,"targetDuration":4,"studyType":23,"phases":205,"briefSummary":206,"conditions":207,"keywords":209,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":47},"100491819","mechanisms-of-risky-alcohol-use-in-young-adults-linking-sleep-to-reward--and-stress-related-brain-function-100491819","NCT05684094","Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep to Reward- and Stress-Related Brain Function","Mechanisms of Risky Alcohol Use in Young Adults: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function","MoRA","Inclusion Criteria:\n\n1. 18-24 years of age;\n2. NIAAA criteria for past-month high-risk drinking (i.e., ≥ 4 drinks\u002Fday or ≥ 8\u002Fweek for women, ≥ 5 drinks\u002Fday or ≥ 15\u002Fweek for men);\n3. short and late sleep (weekday sleep duration ≤ 7.5 hours and bedtime ≥ 24:00 (midnight); n=60) or long and early sleep (weekday sleep duration \\> 7.5 hours and bedtime ≤ 24:00 (midnight); n=30);\n4. at least moderate lifetime exposure to stressors (≥ 2 events on the 20-item Adult Stress and Adversity Inventory-Screener);\n5. not currently in high school; and\n6. English language fluency.\n\nExclusion Criteria:\n\n1. Severe alcohol use disorder (AUD) and\u002For substance use disorder (SUD), defined as ≥6 AUD\u002FSUD criteria in the Diagnostic and Statistical Manual-5;\n2. acute alcohol intoxication on the days of the laboratory post-intensive visits, operationalized as a blood alcohol concentration of .02 or higher during Breathalyzer saliva screen;\n3. current clinician-provided diagnosis of narcolepsy or idiopathic hypersomnia;\n4. lifetime diagnosis of bipolar or schizophrenia spectrum disorder;\n5. certain medical conditions (e.g., serious neurological disorder, heart failure or serious trouble, history of head injury with unconsciousness \\> 5 minutes);\n6. conditions that are contraindicated for MRI (e.g., ferrous metal in the body);\n7. positive screen for participant-reported eye disease, epilepsy, or photosensitizing medications that are contraindicated during the manipulation condition when bright light is administered (e.g., psychiatric neuroleptic drugs \\[e.g., phenothiazine\\], psoralen drugs, antiarrhythmic drugs \\[e.g., amiodarone\\], antimalarial and antirheumatic drugs, porphyrin drugs used in photodynamic treatment of skin diseases);\n8. use of melatonin if participant is not willing to discontinue use for the duration of the study.\n\nWe will schedule around (i.e., delay appointments as needed) to avoid the timeframe of the following events:\n\n1. urgent suicide risk, defined by moderate\u002Fsevere risk per CSSR and clinician determination that current risk requires immediate action;\n2. travel across two or more time zones within the month prior to the overnight study visits.\n3. begin\u002Fend a prescribed medication within 2 months of the observational study;\n4. medication dose changes within the timeframe calculated as 5x the drug's half-life \\[the time to reach pharmacokinetic steady-state\\] before the initiation of the observational or experimental studies;\n5. participant-anticipated changes in prescribed medications or medication dosing during the observational or experimental studies.;\n6. current symptoms of an airborne infectious illness (e.g., COVID) prior to laboratory visits.\n\nParticipants with positive breathalyzer screen (blood alcohol level \\> .02) will be rescheduled for an alternative overnight visit date.","24 Years",{"count":204,"type":22},90,[25],"This research will use biobehavioral approaches to generate understanding about the linkages between stressful life events, sleep duration and timing, and alcohol use in young adults, with a long-term aim of developing effective preventative interventions for alcohol use disorders.",[208],"Alcohol Use Disorder",[210,211,30,212,213,214],"sleep","circadian","substance use","stress","reward","2026-02-25",{"date":217,"type":39},"2026-02-27",{"date":219,"type":39},"2023-09-07",{"date":221,"type":22},"2027-02-28",{"name":45,"class":46},{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":11,"sex":17,"minAge":230,"maxAge":56,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":240,"overallStatus":155,"whyStopped":4,"lastUpdateSubmitDate":251,"lastUpdatePostDateStruct":252,"startDateStruct":254,"completionDateStruct":256,"leadSponsor":258,"locationsCount":4},"100625648","personalizing-mental-health-treatment-for-youth-and-families-100625648","NCT07425366","Personalizing Mental Health Treatment for Youth and Families","Development of a Decision Support Tool for Culturally Adapting Mental Health Treatment to Improve Outcomes for Latine Youths","Inclusion Criteria:\n\n* Identify as Latino\n* Fluent in English or Spanish\n* 5-15 years old\n* Referred to individual psychotherapy with a participating clinician for a primary clinical concern involving anxiety, depression, trauma, or disruptive behaviors\n\nExclusion Criteria:\n\n\\-","5 Years",{"count":232,"type":22},64,[25],"Incompatibility between evidence-based treatments (EBTs) and the cultural values, practices, and minoritized experiences of Latine youth and families contributes to racial-ethnic disparities in mental health treatment engagement and consequently mental health outcomes. The proposed study aims to develop and pilot a novel tool - the Culturally Responsive Assessment, Formulation, and Treatment Tool (CRAFTT) - for helping clinicians decide whether, when, and how to culturally adapt EBTs for individual Latine youth clients and thereby improve the cultural compatibility of EBTs for this underserved population. Completion of this study will result in a functional decision support tool designed to improve the quality and effectiveness of mental health services for Latine youths and promote mental health equity.",[236,237,238,239],"Anxiety","Traumatic Stress","Disruptive Behavior","Depression",[241,242,243,244,245,246,247,248,249,250],"child","anxiety","depression","traumatic stress","disruptive behavior","community mental health","National Institute of Mental Health","treatment adaptation","treatment fidelity","decision support tool","2026-02-18",{"date":253,"type":39},"2026-02-20",{"date":255,"type":22},"2027-01",{"date":257,"type":22},"2028-09",{"name":45,"class":46},{"id":260,"slug":261,"hasResults":11,"nctId":262,"briefTitle":263,"officialTitle":264,"acronym":265,"eligibilityCriteria":266,"healthyVolunteers":11,"sex":17,"minAge":19,"maxAge":114,"enrollmentInfo":267,"targetDuration":4,"studyType":23,"phases":269,"briefSummary":270,"conditions":271,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":47},"100492384","mechanisms-of-depression-and-anhedonia-in-adolescents-linking-sleep-to-reward--and-stress-related-brain-function-100492384","NCT05691439","Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function","Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep Duration and Timing to Reward- and Stress-Related Brain Function","MoDA","Inclusion Criteria:\n\n1. 14-18 years of age\n2. Currently in high school\n3. short and late sleep (weekday sleep duration ≤ 7 h and bedtime ≥ 22:30 (10:30 pm); n=100) or long and early sleep (weekday sleep duration \\> 7 hours and bedtime ≤ 22:30 (10:30 pm); n=50), indexed by the Munich Chronotype Questionnaire\n4. Lifetime stressful event frequency ≥ 2 on the Stress and Adversity Inventory (STRAIN) Screener\n5. Depressive symptom severity t-score greater than or equal to 45 on the Patient Reported Outcomes (PROMIS) Depression scale\n6. English language fluency\n\nExclusion Criteria:\n\n1. Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for current moderate to severe alcohol\u002Fsubstance use disorder (≥4 symptoms);\n2. Current clinician-provided diagnosis of narcolepsy or idiopathic hypersomnia;\n3. Lifetime diagnosis of bipolar or schizophrenia spectrum disorder;\n4. Certain medical conditions (e.g., serious neurological disorder, heart failure or serious heart trouble, history of head injury with unconsciousness \\> 5 minutes);\n5. Conditions that are contraindicated for magnetic resonance imaging (MRI; e.g., ferrous metal in the body);\n6. Positive screen for participant-reported eye disease, epilepsy, or photosensitizing medications that are contraindicated during the manipulation condition when bright light is administered (e.g., psychiatric neuroleptic drugs \\[e.g., phenothiazine\\], psoralen drugs, antiarrhythmic drugs \\[e.g., amiodarone\\], antimalarial and antirheumatic drugs, porphyrin drugs used in photodynamic treatment of skin diseases);\n7. Use of melatonin if participant is not willing to discontinue use for the duration of the study.\n\nWe will schedule around (i.e., delay appointments as needed) to avoid the timeframe of the following events:\n\n1. urgent suicide risk, defined by moderate\u002Fsevere risk per Columbia Suicide Severity Rating Scale (CSSRS) and clinician determination that current risk requires immediate action;\n2. travel across two or more time zones within the month prior to the overnight study visits;\n3. beginning or ending a prescribed medication within 2 months of the observational study;\n4. prescribed medication dose changes within the timeframe calculated as 5x the drug's half-life \\[the time to reach pharmacokinetic steady-state\\] before the initiation of the observational or experimental studies;\n5. anticipated change in prescribed medications or medication dosing during the observational or experimental studies;\n6. current symptoms of airborne infectious illness prior to laboratory visits.\n\nParticipants with positive breathalyzer screen (blood alcohol level \\> .02) will be rescheduled for an alternative overnight visit date.",{"count":268,"type":22},150,[25],"This research will use biobehavioral approaches to generate understanding about the linkages between sleep duration and timing, stressful life events, and depressive symptoms in adolescents, with a long-term aim of developing effective preventative interventions.",[272],"Depression in Adolescence","2025-11-13",{"date":275,"type":39},"2025-11-17",{"date":277,"type":39},"2023-03-27",{"date":279,"type":22},"2026-12-31",{"name":45,"class":46},{"id":282,"slug":283,"hasResults":11,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":4,"eligibilityCriteria":287,"healthyVolunteers":16,"sex":17,"minAge":114,"maxAge":288,"enrollmentInfo":289,"targetDuration":4,"studyType":23,"phases":291,"briefSummary":292,"conditions":293,"keywords":298,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":317,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":323,"locationsCount":47},"100510421","c-protein-in-fatigue-and-aging-100510421","NCT05926219","C-Protein in Fatigue and Aging","Skeletal Muscle Myosin Binding Protein C in Fatigue and Aging","Inclusion Criteria:\n\n* Adults between the ages 18-35 or 65-80 years\n* Healthy by self-report\n* Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring\n* Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English).\n\nExclusion Criteria:\n\n* Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.).\n* Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis.\n* Volunteer has known untreated endocrine disease (hypo\u002Fhyper thyroidism, Addison's Disease or Cushing's syndrome, etc.)\n* Volunteer has untreated\u002Fpoorly-controlled hypertension (stage 2, per American College of Cardiology \\[\\>140\u002F90 mmHg\\]).\n* Volunteer has significant heart, liver, kidney or respiratory disease.\n* Volunteer has diabetes (insulin dependent or non-insulin dependent).\n* Volunteer has known coagulopathies.\n* Volunteer has taken anabolic steroids in the prior six months.\n* Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas)\n* Unexpected weight loss \\>5kg is last 12 months\n* Volunteer is an active smoker or quit within the last year.\n* Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of \\>4 days in the last month. Binge drinking is \\>5 drinks for men and \\>4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of \"low risk\" per NIAAA (\\>7 drinks\u002Fweek for men and \\>3 drinks\u002Fday for women and \\>14 drinks\u002Fweek and \\>4 drinks\u002Fday).\n* Volunteer has a diagnosed neuromuscular disorder.\n* Volunteer has allergy to lidocaine.","80 Years",{"count":290,"type":22},24,[25],"This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.",[294,295,296,297],"Aging","Muscle Atrophy or Weakness","Sarcopenia in Elderly","Sarcopenia",[299,300,301,302,303,304,305,306,307,308,309,310,311,312,313,314,315,316],"muscle","aging","elderly","myosin","protein","sarcomere","exercise","function","atrophy","contractile","strength","balance","mobility","MyBP-C","fiber","biopsy","skeletal muscle","fatigue","2025-05-06",{"date":319,"type":39},"2025-05-07",{"date":321,"type":39},"2017-11-06",{"date":255,"type":22},{"name":45,"class":46},{"id":325,"slug":326,"hasResults":11,"nctId":327,"briefTitle":328,"officialTitle":329,"acronym":330,"eligibilityCriteria":331,"healthyVolunteers":16,"sex":17,"minAge":114,"maxAge":332,"enrollmentInfo":333,"targetDuration":4,"studyType":23,"phases":334,"briefSummary":335,"conditions":336,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":338,"lastUpdatePostDateStruct":339,"startDateStruct":341,"completionDateStruct":343,"leadSponsor":345,"locationsCount":47},"100555030","garden-fresh-foods-and-gut-microbiomes-100555030","NCT06506786","Garden-fresh Foods and Gut Microbiomes","Microbiomes of Garden-fresh vs Store-bought Produce and Variation in Their Effects on the Human Gut Microbiome","GFF","Inclusion Criteria:\n\n\\-\n\nExclusion Criteria:\n\n* Body mass index (BMI) greater than or equal to 35 or less than or equal to 18.\n* Age under 18 or over 45.\n* Female who is pregnant or lactating.\n* Irregular bowel movements and\u002For stool consistency.\n* Plans to travel, move residences, or other major life change during the study period (August-October 2023).\n* Unable to speak, read, and write English.\n* Use of any of the following drugs within the last 6 months:\n* systemic antibiotics, antifungals, antivirals or antiparasitics (intravenous, intramuscular, or oral);\n* oral, intravenous, intramuscular, nasal or inhaled corticosteroids;\n* cytokines;\n* methotrexate or immunosuppressive cytotoxic agents;\n* large doses of commercial probiotics consumed (greater than or equal to 108 cfu or organisms per day) - includes tablets, capsules, lozenges, chewing gum or powders in which probiotic is a primary component. Ordinary dietary components such as fermented beverages\u002Fmilks, yogurts, foods do not apply.\n* Acute disease at the time of enrollment (defer sampling until subject recovers). Acute disease is defined as the presence of a moderate or severe illness with or without fever.\n* History of cancer except for squamous or basal cell carcinomas of the skin that have been medically managed by local excision.\n* Unstable dietary history as defined by major changes in diet during the previous month, where the subject has eliminated or significantly increased a major food group in the diet.\n* Recent history of chronic alcohol consumption defined as more than five 1.5-ounce servings of 80 proof distilled spirits, five 12-ounce servings of beer or five 5-ounce servings of wine per day.\n* Any confirmed or suspected condition\u002Fstate of immunosuppression or immunodeficiency (primary or acquired) including HIV infection.\n* Major surgery of the GI tract, with the exception of cholecystectomy and appendectomy, in the past five years. Any major bowel resection at any time.\n* History of active uncontrolled gastrointestinal disorders or diseases including:\n* inflammatory bowel disease (IBD) including ulcerative colitis (mild-moderate-severe), Crohn's disease (mild-moderate-severe), or indeterminate colitis;\n* irritable bowel syndrome (IBS) (moderate-severe);\n* persistent, infectious gastroenteritis, colitis or gastritis, persistent or chronic diarrhea of unknown etiology, Clostridium difficile infection (recurrent) or Helicobacter pylori infection (untreated);\n* chronic constipation.","45 Years",{"count":171,"type":22},[25],"The purpose of this research is to explore what types of microbes are present on garden-fresh versus store-bought fruits and vegetables, as well as how they might affect the human gut microbiome.",[337],"Gut Microbiome","2024-07-16",{"date":340,"type":39},"2024-07-17",{"date":342,"type":39},"2023-07-01",{"date":344,"type":22},"2024-12-31",{"name":45,"class":46},""]