[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Oslo\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":430},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,16,0,[8,42,66,93,113,140,169,212,245,263,283,317,342,366,383,402],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":30,"lastUpdatePostDateStruct":31,"startDateStruct":34,"completionDateStruct":36,"leadSponsor":38,"locationsCount":41},"100366523","peri-implantitis-implantoplasty-treatment-100366523",false,"NCT04052373","Peri-implantitis Implantoplasty Treatment","Surgical Peri-implantitis Treatment With and Without Implantoplasty","Inclusion Criteria:\n\n* Peri-implantitis (according to 2018 criteria) on minimum 2 implants of similar surface and defect type\n* Competent to give consent\n* Exposed, modified implant surface with loss \\>2mm\n\nExclusion Criteria:\n\n* Previous radiotherapy to the jaws, current use of chemotherapy, systemic long-term corticosteroid treatment\n* Present or past use of bisphosphonate treatment • Pregnant or nursing subjects\n* Patients classified as \\> class II according to ASA classification\n* Implant unavailable for implantoplasty treatment\n* Inhability to comprehend and respond to the quality of life questionnaire\n* Examiners\u002Foperators deem original placement of implant (angle, position) suboptimal and considered to play a major role in development of peri-implantitis\n* History of peri-implantitis surgery prior to 6 months of screening",true,"ALL","20 Years",{"count":20,"type":21},35,"ESTIMATED","INTERVENTIONAL",[24],"NA","This double arm, split-mouth, single centre, controlled, randomised clinical study is designed to examine the effect of implantoplasty in treatment of peri-implantitis.\n\nPeri-implantitis will be treated with open flap debridement, with or without implantoplasty.",[27,28],"Peri-Implantitis","Peri-implant Mucositis","RECRUITING","2026-04-28",{"date":32,"type":33},"2026-04-29","ACTUAL",{"date":35,"type":33},"2019-10-15",{"date":37,"type":21},"2027-06-15",{"name":39,"class":40},"University of Oslo","OTHER",2,{"id":43,"slug":44,"hasResults":11,"nctId":45,"briefTitle":46,"officialTitle":47,"acronym":4,"eligibilityCriteria":48,"healthyVolunteers":16,"sex":17,"minAge":49,"maxAge":50,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":54,"conditions":55,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":57,"lastUpdatePostDateStruct":58,"startDateStruct":60,"completionDateStruct":62,"leadSponsor":64,"locationsCount":65},"100516372","oral-chemosensory-and-trigeminal-functions-in-allo-hsct-100516372","NCT06003660","Oral, Chemosensory and Trigeminal Functions in Allo-HSCT","Oral, Chemosensory and Trigeminal Functions in Allogeneic Hematopoietic Stem Cell Transplantation - a Prospective Cohort-study","Inclusion Criteria:\n\n• patients receiving myeloablative conditioning for a first-time allo-HSCT and diagnosed with either a leukemia or a myelodysplastic syndrome\n\nExclusion Criteria:\n\n* disorders affecting the oral cavity including poor tooth-status\n* those using drugs affecting the gustatory\u002Folfactory functions\n* those with brain disorders\n* those who have a chronic disorder affecting the immune system, have cancer or who are pregnant.","30 Years","70 Years",{"count":52,"type":21},70,"OBSERVATIONAL","The goal of this prospective, cohort study is to learn about smell, taste and trigeminal dysfunction in patients receiving allogeneic hematopoietic stem cell transplantation (allo-HSCT). The research team hypothesizes that treatment with allo-HSCT will induce:\n\n* Distortion of taste and smell and trigeminal functions like cooling, tingling, and burning sensations.\n* Reduced saliva production leading to oral dryness and dental caries.\n* Changes in the connectivity of the taste-, smell- and pain-cortical brain regions.",[56],"Hematopoietic Stem Cell Transplantation","2026-04-27",{"date":59,"type":33},"2026-05-01",{"date":61,"type":33},"2023-08-10",{"date":63,"type":21},"2028-03-01",{"name":39,"class":40},1,{"id":67,"slug":68,"hasResults":11,"nctId":69,"briefTitle":70,"officialTitle":70,"acronym":71,"eligibilityCriteria":72,"healthyVolunteers":11,"sex":17,"minAge":73,"maxAge":74,"enrollmentInfo":75,"targetDuration":4,"studyType":22,"phases":77,"briefSummary":78,"conditions":79,"keywords":82,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":65},"100619614","digital-interventions-for-relapse-prevention-in-adolescence-100619614","NCT07346911","Digital Interventions for Relapse Prevention in Adolescence","DigiTIFF","Inclusion Criteria:\n\n* Currently in full or partial remission for a minimum of 2 months from a depressive disorder or an anxiety disorder as defined by self-reported scores on RCADS-47: previous episode(s) of t-score \\> 65 and current t-score =\\\u003C65.\n* Native or fluent Scandinavian language skills.\n* Willingness to take part even when allocated to the non-preferred arm of the trial.\n\nExclusion Criteria:\n\n* Ongoing depressive disorder, ongoing anxiety disorder as defined by current t-score =\\\u003C65 on RCADS-47.\n* Recent completion of one of the interventions in the two interventional arms.\n* no available smartphone.","16 Years","19 Years",{"count":76,"type":21},495,[24],"Some adolescents experience periods of anxiety and\u002For depression, and some find that these periods return over time. The purpose of this study is to examine whether digital interventions-where individuals work systematically with their own thoughts and feelings during periods when they feel well-can help them maintain well-being for longer.\n\nThe study includes adolescents aged 16-19 who have previously experienced episodes of depression and\u002For anxiety to a degree that led them to seek help (e.g., from a school nurse, general practitioner, health clinic, or child and adolescent mental health service). Through a research app on their smartphones, participants complete tasks and answer questionnaires. The study is fully digital. Some participants meet with a therapist in digital group sessions, while others work independently with the digital content.\n\nWe will also examine the cost-benefit aspects of offering such interventions. If the study achieves its goals, digital interventions may eventually become a service offered to adolescents recovering from depression and anxiety.",[80,81],"Major Depression Disorder","ANXIETY DISORDERS (or Anxiety and Phobic Neuroses)",[83],"Transdiagnostic interventions","NOT_YET_RECRUITING","2026-03-12",{"date":87,"type":33},"2026-03-13",{"date":89,"type":21},"2026-04-07",{"date":91,"type":21},"2027-06-01",{"name":39,"class":40},{"id":94,"slug":95,"hasResults":11,"nctId":96,"briefTitle":97,"officialTitle":97,"acronym":4,"eligibilityCriteria":98,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":4,"enrollmentInfo":100,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":102,"conditions":103,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":105,"lastUpdatePostDateStruct":106,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":65},"100625904","from-bench-to-bedside-a-machine-learning-tool-for-the-detection-of-inspiratory-leak-100625904","NCT07428694","From Bench to Bedside: A Machine Learning Tool for the Detection of Inspiratory Leak","Inclusion Criteria:\n\n* elective hospitalisation for control of non-invasive ventilation\n* use of ResMedLumis 100\u002F150 ventilator\n* treatment for \\>3 months\n\nExclusion Criteria:\n\n* current exacerbation","18 Years",{"count":101,"type":21},20,"Study of the applicability of machine learning tools in detecting inspiratory leakage in longterm non-invasive ventilation. The study was conducted in two stages. Firstly the ML model was trained on both bench model created scenarios and then ten patients. And secondly the success of the model was assessed in a proof of concept pilot study of ten patients.",[104],"Chronic Respiratory Failure","2026-02-17",{"date":107,"type":33},"2026-02-24",{"date":109,"type":33},"2025-10-01",{"date":111,"type":21},"2026-10-01",{"name":39,"class":40},{"id":114,"slug":115,"hasResults":11,"nctId":116,"briefTitle":117,"officialTitle":117,"acronym":118,"eligibilityCriteria":119,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":120,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":129,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":132,"lastUpdatePostDateStruct":133,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":65},"100624365","mechanisms-of-change-in-psychotherapy-the-effects-of-cognitive-behavioral-therapy-and-psychodynamic-therapy-in-once---versus-twice---weekly-sessions-on-outcomes-in-depression-100624365","NCT07408687","Mechanisms Of Change in Psychotherapy: The Effects of Cognitive Behavioral Therapy and Psychodynamic Therapy in Once - Versus Twice - Weekly Sessions on Outcomes in Depression.","MOP II","Inclusion criteria:\n\n* age 18-65 years\n* Major Depressive Disorder Hamilton Depression Rating Scale (HDRS) \\> 14.\n* Speak and understand a Scandinavian language\n* Willingness and ability to give informed consent.\n\nExclusion Criteria:\n\n* Current or past neurological illness\n* Traumatic brain injury\n* Current alcohol and\u002For substance dependency disorders\n* Psychotic disorders\n* Bipolar disorders\n* Developmental disorders\n* IQ \\\u003C70.","65 Years",{"count":122,"type":21},200,[24],"The MOP II study examines how to improve therapy for people struggling with a depressive disorder. Cognitive Behavioral Therapy (CBT) and Short-Term Psychodynamic Psychotherapy (STPP) are two evidence-based treatments for depression that are widely used. Meta-analyses indicate that CBT and STPP are one average equally effective and superior to no treatment. However, many patients do not respond sufficiently and relapse rates after acute phase treatment are high.\n\nEarlier research and theoretical insights suggest three promising strategies to enhance the effectiveness of psychotherapy. First, we want to examine whether increasing the frequency of the sessions will increase the effect of therapy. We want to compare once-weekly and twice-weekly sessions in both CBT and STPP to see whether more frequent sessions lead to better and more lasting reductions in depressive symptoms with the same total number of sessions.\n\nSecond, the study aims to answer what works for whom in two different psychotherapeutic approaches. People with depression differ in personality, life experiences, relationship styles, and how they understand the causes of their depression. Previous findings suggest that patients do better when the therapy approach matches how they see their problems. The MOP II study wants to replicate this finding.\n\nThird, the study wants to examine how therapy leads to change. In CBT, improvement is thought to happen through changes in thinking patterns, such as fewer negative automatic thoughts and less rumination. In STPP, change is expected to come from better self-understanding, greater emotional awareness, and healthier ways of relating to others.\n\nConsequently, the goal of the MOP II study is to find out whether more frequent therapy, better matching of patients to treatment type, and a clearer understanding of how therapy works can lead to faster improvement of depressive symptoms.",[126,127,128],"Depression - Major Depressive Disorder","Cognitive Behavior Therapy","Psychodynamic Therapy",[130,131],"Mechanisms of change in Psychotherapy","Frequency of therapy sessions","2026-02-13",{"date":134,"type":33},"2026-02-18",{"date":136,"type":21},"2026-03-01",{"date":138,"type":21},"2030-12-31",{"name":39,"class":40},{"id":141,"slug":142,"hasResults":11,"nctId":143,"briefTitle":144,"officialTitle":145,"acronym":146,"eligibilityCriteria":147,"healthyVolunteers":16,"sex":17,"minAge":120,"maxAge":4,"enrollmentInfo":148,"targetDuration":4,"studyType":22,"phases":150,"briefSummary":151,"conditions":152,"keywords":155,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":161,"lastUpdatePostDateStruct":162,"startDateStruct":164,"completionDateStruct":166,"leadSponsor":168,"locationsCount":65},"100616962","b-vitamins-and-omega-3-fatty-acids-and-biomarkers-of-brain-atrophy-100616962","NCT07312435","B-vitamins and Omega-3 Fatty Acids and Biomarkers of Brain Atrophy.","B-vitamins and ω-3 Fatty Acids to Modulate Brain Ageing in European Citizens Through Improved Nutrition: the BOOMERANG Project","BOOMERANG","Inclusion Criteria:\n\n* Age \\> 65 years\n* A low baseline B-vitamin status as assessed by plasma tHcy \\> 11 μmol\u002FL\n* Normal MMSE score (\\>25)\n\nExclusion Criteria:\n\n* Unable to give informed consent\n* Fatty fish intake \\> 2 times per week\n* daily omega-3 supplementation\n* daily B-vitamin supplementation\n* history of B12-injections\n* Serum creatinine \\> 90 μmol\u002FL for women and \\> 105 μmol\u002FL for men (above reference values)\n* aspirin use\n* renal disease\n* active cancer\n* Participants can be included if they accept to not take omega-3 supplementation or B-vitamin supplements during the study. They should stop using it and wait 12 weeks before they are invited to a screening visit.",{"count":149,"type":21},96,[24],"A poor nutrition status is a modifiable risk factor for cognitive decline and dementia. In particular, evidence links low status of certain B-vitamins and ω-3 fatty acids (ω-3 FA) with a greater risk of cognitive decline and dementia. Although these dietary components are typically investigated separately, post-hoc analyses of existing clinical trial data and experimental work indicate that B-vitamins and ω-3 FA may exert synergistic beneficial effects on processes related to brain health and cognition. However, this combination has not been tested directly in humans. In the proposed BOOMERANG project, we will study the effects of jointly supplementing with B-vitamins and a highly bioavailable ω-3 FA supplement, Lysoveta, on a robust biomarker of brain atrophy, the neurofilament light chain, in a double-blinded randomized controlled trial (RCT) over 3 months in older adults. We will also examine the secondary effects of the supplement of quality of life and cognitive function.",[153,154],"Dementia","Cognitive Function",[156,157,158,159,160],"Nutrition","Omega3","B vitamins","older adults","cognition","2025-12-16",{"date":163,"type":33},"2025-12-31",{"date":165,"type":33},"2025-09-01",{"date":167,"type":21},"2028-06-01",{"name":39,"class":40},{"id":170,"slug":171,"hasResults":11,"nctId":172,"briefTitle":173,"officialTitle":174,"acronym":175,"eligibilityCriteria":176,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":4,"enrollmentInfo":177,"targetDuration":4,"studyType":22,"phases":179,"briefSummary":180,"conditions":181,"keywords":190,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":203,"lastUpdatePostDateStruct":204,"startDateStruct":206,"completionDateStruct":208,"leadSponsor":210,"locationsCount":211},"100581693","one-hour-troponin-using-a-high-sensitivity-point-of-care-assay-in-emergency-primary-care-100581693","NCT06853626","One-hoUr Troponin Using a High-sensitivity Point-Of-Care Assay in Emergency Primary Care","Improved Management of Acute Chest Pain in Emergency Primary Care. The OUT-POC Study (One-hoUr Troponin Using a High-sensitivity Point-Of-Care Assay in Emergency Primary Care)","OUT-POC","Inclusion Criteria:\n\n* Patients (18+ years) with non-traumatic acute chest pain presenting in emergency primary care\n* Troponin testing requested by the treating physician\n\nExclusion Criteria:\n\n* Acute STEMI (direct hospital referral required)\n* Haemodynamically unstable (direct hospital referral required)\n* Not able to provide written, informed consent (i.e., due to time restraints, language barriers, impaired cognitive function, or other reasons)",{"count":178,"type":21},2500,[24],"Acute chest pain is a prevalent medical emergency in primary emergency care settings. Triage of chest pain prior to hospital admission presents significant challenges due to the absence of sufficiently sensitive diagnostic tools. Clinical signs, symptoms, risk assessment scores, or a normal electrocardiogram (ECG) can reliably exclude acute myocardial infarction (MI). This diagnostic uncertainty has resulted in chest pain being the second most common cause for acute hospital referrals from Norwegian emergency primary care, even though chest pain is frequently non-cardiac in origin.\n\nIn acute MI events, cardiac troponins are released into the bloodstream from the damaged myocardium, where low values are used to exclude MI. Until recently, such testing has necessitated using high-sensitivity cardiac troponin (hs-cTn) assays, which have been limited to hospital laboratories. However, recent technological advancements in point-of-care (POC) testing allow access to whole-blood assays that meet high-sensitivity criteria.\n\nIn this upcoming project, the investigators will evaluate the implementation of a whole-blood POC assay (QuidelOrtho TriageTrue hs-cTnI) across six Norwegian emergency primary care clinics. The study plans to enrol 2,500 patients over a period of 1.5 years. The clinical performance of the novel strategy will be investigated, as well as its impact on healthcare utilization and hospital referrals compared to standard care. Additionally, the investigators will assess the prevalence of persistent chest pain and its effects on quality of life, alongside psychological stress and anxiety, through validated questionnaires.\n\nThis project aims to offer better and more comprehensive management of the large group of emergency primary care patients with acute chest pain, contributing to reduced hospital referrals, improved quality of life, and more sustainable use of healthcare services.",[182,183,184,185,186,187,188,189],"Acute Myocardial Infarction (AMI)","Chest Pain","Acute Coronary Syndromes (ACS)","Non-cardiac Chest Pain","Troponin","Point of Care Testing","Out-of-hours Medical Care","Primary Care",[191,192,193,194,195,196,197,198,199,200,201,175,202],"TriageTrue","POC","hs-cTnI","0\u002F1-hour algorithm","troponin","chest pain","primary care","OOH","out-of-hours","acute myocardial infarction","point-of-care","QuidelOrtho","2025-12-09",{"date":205,"type":33},"2025-12-10",{"date":207,"type":33},"2025-06-27",{"date":209,"type":21},"2029-12-31",{"name":39,"class":40},6,{"id":213,"slug":214,"hasResults":11,"nctId":215,"briefTitle":216,"officialTitle":217,"acronym":4,"eligibilityCriteria":218,"healthyVolunteers":11,"sex":17,"minAge":219,"maxAge":50,"enrollmentInfo":220,"targetDuration":4,"studyType":22,"phases":222,"briefSummary":223,"conditions":224,"keywords":228,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":238,"startDateStruct":240,"completionDateStruct":242,"leadSponsor":244,"locationsCount":41},"100495982","heart-rate-informed-changes-in-care-for-non-communicating-patients-100495982","NCT05738278","Heart Rate Informed Changes in Care for Non-Communicating Patients","Heart Rate Informed Changes in Care for Non-Communicating Patients: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Between 5 and 70 years of age at the time of data collection\n* Autism spectrum disorder as evaluated by clinical psychologist\n* Communication difficulties\n* Living at a care home with round-the-clock staff for at least five days a week; or attending one-to-one staffed school\u002Fday-care at least five days a week.\n* Written informed consent is obtained from the subjects' legal representative.\n\nExclusion Criteria:\n\n\\- Having any autoimmune disorder or any type of cancer with ongoing chemotherapy.","5 Years",{"count":221,"type":21},38,[24],"The overarching aim is to generate knowledge to reduce incidence of pain in non-verbal patients' everyday life. The trial will 1) evaluate how HR can be used to identify potentially painful care procedures that should be re-evaluated in terms of the approach taken; 2) test the effect of heart rate (HR)-informed changes in potentially painful care procedures on biomarkers of pain, and 3) assess how six weeks of communication through HR affects the quality of communication between patient and caregiver.",[225,226,227],"Autism Spectrum Disorder","Intellectual Disability","Communication, Nonverbal",[229,230,226,231,232,233,234,235,236],"Heart Rate","Autistic Disorder","Social Interaction","Caregivers","Developmental Disabilities","Communication","Biomarkers","Pain","2025-07-01",{"date":239,"type":33},"2025-07-04",{"date":241,"type":33},"2023-02-27",{"date":243,"type":21},"2025-12-30",{"name":39,"class":40},{"id":246,"slug":247,"hasResults":11,"nctId":248,"briefTitle":249,"officialTitle":249,"acronym":4,"eligibilityCriteria":250,"healthyVolunteers":11,"sex":17,"minAge":73,"maxAge":4,"enrollmentInfo":251,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":253,"conditions":254,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":258,"startDateStruct":259,"completionDateStruct":261,"leadSponsor":262,"locationsCount":65},"100434531","cognitive-function-and-fatigue-after-brain-abscess-100434531","NCT04938362","Cognitive Function and Fatigue After Brain Abscess","Inclusion criteria:\n\n• Patients who have completed treatment for brain abscess and who agree to participate.\n\nExclusion criteria:\n\n* Patients who cannot undergo neuropsychological investigation due to unconsciousness\n* Patients who cannot undergo neuropsychological investigation, being mentally too ill\n* Patients who suffer from dementia\n* Patients who cannot undergo FDG-PET due to claustrophobia\n* Patients who cannot undergo EEG due to panic attacks\n* Age under 16.",{"count":252,"type":21},50,"Brain abscess is a focal bacterial or fungal infection of the brain. Treatment is neurosurgical drainage of pus followed by long-term antibiotic treatment. In spite of successful treatment of the infection, long-term cognitive problems or mental fatigue may ensue. The reason for this dysfunction may be a continuing inflammatory state or damage to brain tissue caused by the abscess. The investigators will evaluate these possibilities with the use of \\[18F\\]deoxyglucose-positron emission tomography (FDG-PET) and electroencephalography (EEG) in patients who have been treated for brain abscess and who experience cognitive problems and\u002For fatigue. FDG-PET may identify both inflammation and altered neuronal activity (the latter indicating damage to brain tissue), and EEG may identify altered neuronal activity, including changes in neuronal network activity.",[255,256,257],"Brain Abscess","Fatigue","Cognitive Dysfunction",{"date":239,"type":33},{"date":260,"type":33},"2020-01-01",{"date":138,"type":21},{"name":39,"class":40},{"id":264,"slug":265,"hasResults":11,"nctId":266,"briefTitle":267,"officialTitle":268,"acronym":4,"eligibilityCriteria":269,"healthyVolunteers":11,"sex":17,"minAge":219,"maxAge":270,"enrollmentInfo":271,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":273,"conditions":274,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":237,"lastUpdatePostDateStruct":277,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":65},"100377804","sensors-for-communication-for-persons-who-cannot-communicate-unequivocally-100377804","NCT04199299","Sensors for Communication for Persons Who Cannot Communicate Unequivocally","The Use of Sensors to Improve Communication for Persons With Intellectual Disability Who Cannot Communicate Unequivocally","Inclusion Criteria:\n\n* intellectual disability with or without autism and\u002For cerebral palsy that render the participant unable to communicate his\u002Fher needs and reactions unequivocally.\n\nExclusion Criteria:\n\n* allergic skin reaction to chest strap","80 Years",{"count":272,"type":21},100,"Some persons with intellectual disability or comprehensive cerebral palsy cannot communicate unequivocally how they are, how they react to situations and people, whether they are in pain or experience discomfort, anger or fear. Their modes of communication (sounds, grimacing etc) may be unintelligible or ambiguous to their caregivers.\n\nWith the use of heart and\u002For respiration monitors the investigators aim to give these persons a means to communicate their immediate reactions or responses. The respiration monitor is meant to register sleep at night, so that the participants can communicate whether they have slept well or not the previous night.",[226,275,276],"Autism","Cerebral Palsy",{"date":239,"type":33},{"date":279,"type":33},"2020-02-01",{"date":281,"type":21},"2032-12-31",{"name":39,"class":40},{"id":284,"slug":285,"hasResults":11,"nctId":286,"briefTitle":287,"officialTitle":288,"acronym":4,"eligibilityCriteria":289,"healthyVolunteers":11,"sex":17,"minAge":50,"maxAge":4,"enrollmentInfo":290,"targetDuration":4,"studyType":22,"phases":292,"briefSummary":293,"conditions":294,"keywords":296,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":308,"lastUpdatePostDateStruct":309,"startDateStruct":311,"completionDateStruct":313,"leadSponsor":315,"locationsCount":316},"100491627","advanced-care-planning-for-the-severely-ill-home-dwelling-elderly-100491627","NCT05681585","Advanced Care Planning for the Severely Ill Home-dwelling Elderly","Implementing Advanced Care Planning in the Routine Care for Acutely Admitted Patients in Geriatric Units: a Cluster Randomised Controlled Trial","Inclusion and exclusion criteria for patients and relatives the quantitative and triadic sub-study:\n\nInclusion criteria for patients:\n\n* Home-dwelling\n* 70 years or older\n* Acutely admitted to the participating unit\n* Sufficient language proficiency in Norwegian to answer the questionnaire\n* Clinical frailty score of 4 or more\n* The physician responsible for the patient's medical care answers \"no\" to \"Surprise question\" from Gold Standards Framework proactive identification guidance\n* Both patient and a close relative (preferably the closest relative) would participate in ACP together if offered\n* Both patient and the close relative consent to participate in the research project\n\nExclusion criteria for patients:\n\n* The patient is not competent to consent to research participation\n* The patient is expected to die within 24 hours\n* The patient has participated in ACP prior to the current hospital admission\n* In the intervention arm\n\n  * ACP is not conducted with patient, next of kin and physician before hospital discharge\n  * The clinician that participated in the ACP conversation has not consented to research participation\n* In the control arm\n\n  * The patient would not have been able to participate in ACP during hospitalization\n  * An attending clinician has not consented to research participation\n\nInclusion criteria for relatives:\n\n* A close relative of a patient who fulfill all inclusion criteria and no exclusion criteria; and who would be willing to participate in ACP together with the patient if offered\n* 18 years or older\n* Sufficient language proficiency in Norwegian to answer the questionnaire\n* Both patient and the close relative consent to participate in the research project\n\nExclusion criteria for relatives:\n\n* The relative is not competent to consent to research participation\n* In the intervention arm\n\n  * ACP is not carried out with the patient, next of kin and attending clinician before hospital discharge\n* In the control arm\n\n  * The relative would not have been able to participate in ACP during hospitalization",{"count":291,"type":21},2000,[24],"This study will develop and evaluate a complex intervention to implement advance care planning for severely ill home-dwelling elderly acutely admitted to hospital, by using a cluster randomized design.\n\nTwelve Norwegian acute geriatric hospital units will participate in the main study, each as one cluster. Of the twelve clusters, half will receive implementation support and training immediately, and the other half will receive similar support after the intervention period. The study includes 1) assessment of implementation outcomes (fidelity) in the participating units,2) health service and clinical outcomes including a) questionnaires to all staff in the units before and after the implementation period, questionnaires to attending clinicians and qualitative interviews with health personnel and local unit leaders b) questionnaires to patients and their relatives, patients records and data from central health registers and qualitative interviews with patients and relatives. Furthermore we will assess barriers and facilitators for advance care planning in 1) a wider health service context, and 2) at the national, regional and municipal level, and do economic analyses.",[295],"Advance Care Planning",[297,298,299,300,301,302,303,304,305,306,307],"Implementation science","Decision-making processes","Hospital","Geriatric","Next of kin","Clinical ethics","Qualitative methods","Cluster randomized clinical trial","Complex intervention","Health services for the aged","End of life","2025-04-02",{"date":310,"type":33},"2025-04-06",{"date":312,"type":33},"2023-10-18",{"date":314,"type":21},"2026-12",{"name":39,"class":40},12,{"id":318,"slug":319,"hasResults":11,"nctId":320,"briefTitle":321,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":4,"enrollmentInfo":323,"targetDuration":4,"studyType":22,"phases":324,"briefSummary":325,"conditions":326,"keywords":328,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":334,"lastUpdatePostDateStruct":335,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":65},"100582694","cognitive-behavioural-therapymetacognitive-therapy-for-low-self-esteem-100582694","NCT06866639","Cognitive Behavioural Therapy\u002FMetacognitive Therapy for Low Self Esteem","Inclusion Criteria:\n\n1. Signed written informed consent obtained prior to entry in the study.\n2. Scores below 15 on the Rosenberg Self-esteem Scale (RSE)\n3. 18 years or older.\n\nExclusion Criteria:\n\n1. Psychosis\n2. Bipolar type 1\n3. Current suicide intent\n4. PTSD\n5. Cluster A or cluster B personality disorder\n6. Substance dependence",{"count":101,"type":21},[24],"The goal for this clinical trial is to explore the effect of CBT\u002FMCT on the treatment of low self esteem. 20 patients with low self-esteem will be selected and distributed into two either MCT or a CBT\n\nWe aim in this study to (1) evaluate the accessibility and effectiveness of MCT and CBT in treating low self-esteem, (2) investigate the patterns of change and the mechanisms of action involved during treatment, and (3) examine the impact of meta-cognitions and neuropsychologial processes in the treatment response and any relapse prevention of low self-esteem.",[327],"Psychological Disorders",[329,330,331,332,333],"low self esteem","cognitive behavioural therapy","metacognitive therapy","depressive symptoms","anxiety symptoms","2025-03-05",{"date":336,"type":33},"2025-03-10",{"date":338,"type":21},"2025-03-01",{"date":340,"type":21},"2026-08-01",{"name":39,"class":40},{"id":343,"slug":344,"hasResults":11,"nctId":345,"briefTitle":346,"officialTitle":346,"acronym":4,"eligibilityCriteria":347,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":348,"targetDuration":4,"studyType":22,"phases":350,"briefSummary":351,"conditions":352,"keywords":354,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":359,"startDateStruct":361,"completionDateStruct":363,"leadSponsor":365,"locationsCount":65},"100572750","spit-frequency-iperi-implant-mucositis-100572750","NCT06737328","SPiT-frequency I_Peri-implant Mucositis","Inclusion Criteria:\n\n* Subject must be ≥ 20 years, diagnosed with peri-implant mucositis as defined by the World Workshop 2017 criteria (Berglundh et al., 2018) at an adequate (\\\u003C0.5mm) bone level Peri-implant mucositis: Bleeding after gentle probing at an implant and no radiographic bone loss)\n\nExclusion Criteria:\n\n* Previous radiotherapy in the affected area, current use of chemotherapy, systemic long-term corticosteroid treatment.\n\n  * No pregnant or nursing subjects.\n  * \\> class 2 according to the ASA (American Society of Anesthesiologists) physical status classification.\n  * HIV positive or other disease severely affecting the immune system\n  * If examiners\u002Foperators agree the placement of the implant (angle, position, proximity to adjacent implant or tooth) or suprastructure was suboptimal and considered to play a major role in the development of inflammation.\n  * Anatomical abnormalities.",{"count":349,"type":21},60,[24],"This is an interventional clinical study on the peri-implant treatment necessary to improve the clinical conditions surrounding dental implants registered with peri-implant inflammation. The focus of this double-armed, examiner blinded, controlled, randomized clinical trial is to examine the effect of short-term increased frequency of a SPiT (supportive peri-implant treatment) protocol on implants diagnosed with peri-implant mucositis.\n\nThe study is a part of a project assessing the frequency of supportive peri-implant therapy. The current is on treatment of peri-implant mucositis (inflammation and no attachment loss at the implants) and secondary prevention of peri-implant mucositis. The other study is a RCT on non-surgical treatment of peri-implantitis (inflammation and exposed implant surface) (REK 790240). Exposure of rough surface may dramatically change the frequency of maintenance needed to improve the inflammatory condition. Thus, a segregation between adequate and low bone level at the implant is necessary.\n\nSubjects with more than one implant and both diagnoses, may be enrolled in both studies, following the frequency of treatment randomized in the peri-implant mucositis study.",[353],"Peri-Implantitis and Peri-implant Mucositis",[355,356,357],"Peri-implant mucositis","Supportive peri-implant treatment","Frequency","2024-12-11",{"date":360,"type":33},"2024-12-17",{"date":362,"type":21},"2025-01-01",{"date":364,"type":21},"2028-01-19",{"name":39,"class":40},{"id":367,"slug":368,"hasResults":11,"nctId":369,"briefTitle":370,"officialTitle":370,"acronym":4,"eligibilityCriteria":371,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":372,"targetDuration":4,"studyType":22,"phases":373,"briefSummary":374,"conditions":375,"keywords":376,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":358,"lastUpdatePostDateStruct":379,"startDateStruct":380,"completionDateStruct":381,"leadSponsor":382,"locationsCount":65},"100572749","spit-frequency-iiperi-implantitis-100572749","NCT06737315","SPiT-frequency II_Peri-implantitis","Inclusion Criteria:\n\n* \\- Subject must be ≥ 20 years, diagnosed with peri-implantitis as defined by the World Workshop 2017 criteria (Berglundh et al., 2018) with a bone level \\> 3 mm from the expected initial bone level Peri-implantitis: Bleeding after gentle probing at an implant and radiographic bone level \\> 3 mm\n\nExclusion Criteria:\n\n* \\- Previous radiotherapy in the affected area, current use of chemotherapy, systemic long-term corticosteroid treatment.\n\n  * No pregnant or nursing subjects.\n  * \\> class 2 according to the ASA (American Society of Anesthesiologists) physical status classification.\n  * HIV positive or other disease severely affecting the immune system\n  * If examiners\u002Foperators agree the placement of the implant (angle, position, proximity to adjacent implant or tooth) or suprastructure was suboptimal and considered to play a major role in the development of inflammation.\n  * Anatomical abnormalities.",{"count":349,"type":21},[24],"This is an interventional clinical study on the peri-implant treatment necessary to improve the clinical conditions surrounding dental implants registered with peri-implant inflammation. The focus of this double-armed, examiner blinded, controlled, randomized clinical trial is to examine the effect of short-term increased frequency of a Non-surgical protocol on implants diagnosed with peri-implantitis.\n\nThe study is a part of a project assessing the frequency of supportive peri-implant therapy. The current is on non-surgical treatment of peri-implantitis (inflammation and exposed implant surface). The other study is a RCT on treatment of peri-implant mucositis (inflammation and no attachment loss at the implants) and secondary prevention of peri-implant mucositis (REK 790097). Exposure of rough surface may dramatically change the frequency of maintenance needed to improve the inflammatory condition. Thus, a segregation between adequate and low bone level at the implant is necessary.\n\nSubjects with more than one implant and both diagnoses, may be enrolled in both studies, following the frequency of treatment randomized in the peri-implant mucositis study",[353],[377,378,357],"Peri-implantitis","Non-surgical treatment",{"date":360,"type":33},{"date":362,"type":21},{"date":364,"type":21},{"name":39,"class":40},{"id":384,"slug":385,"hasResults":11,"nctId":386,"briefTitle":387,"officialTitle":387,"acronym":4,"eligibilityCriteria":388,"healthyVolunteers":11,"sex":17,"minAge":99,"maxAge":4,"enrollmentInfo":389,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":391,"conditions":392,"keywords":4,"overallStatus":29,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":65},"100460553","the-immune-response-to-stroke-100460553","NCT05277129","The Immune Response to Stroke","Inclusion Criteria:\n\n* Stroke \\\u003C 72 h\n* Age \\> 18 years\n\nExclusion Criteria:\n\n* Brain hemorrhage verified by CT or MRI scan\n* Previous or present immunological disease or other serious comorbidity\n* Ongoing immune respons after infection or vaccination \\\u003C 1 month\n* Cognitive without ability to understand and\u002For give an informed consent to participate in the study",{"count":390,"type":21},40,"Some patients develop cognitive decline after a stroke, but we don't always understand the mechanisms. It has been proposed that a proportion of the patients develop an autoimmune immune response, and that this could potentially explain the cognitive decline in some of the patients. The current study aims to investigate this hypothesis in a subgroup of patients with stroke.",[393,153],"Stroke, Acute","2022-03-03",{"date":396,"type":33},"2022-03-14",{"date":398,"type":33},"2021-06-24",{"date":400,"type":21},"2029-06-06",{"name":39,"class":40},{"id":403,"slug":404,"hasResults":11,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":11,"sex":409,"minAge":99,"maxAge":410,"enrollmentInfo":411,"targetDuration":4,"studyType":53,"phases":4,"briefSummary":413,"conditions":414,"keywords":418,"overallStatus":84,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":427,"leadSponsor":429,"locationsCount":4},"100396810","maternal-health-care-and-pregnancy-outcomes-in-undocumented-migrant-women-in-norway-100396810","NCT04446949","Maternal Health Care and Pregnancy Outcomes in Undocumented Migrant Women in Norway.","Documenting the Undocumented - The Use of Maternal Health Care and Pregnancy Outcomes in Undocumented Migrant Women in Norway.","Inclusion Criteria:\n\n* No registered Norwegian identity number\n* Female\n\nExclusion Criteria:\n\n* Male","FEMALE","50 Years",{"count":412,"type":21},70000,"Little research on the health service utilization and the health situation of undocumented pregnant migrants has been performed previously, and it is essential to obtain more information on the services given, and to examine whether residency status is a risk factor in maternal and perinatal health among migrants.This project will give new knowledge on undocumented women seeking care at the voluntary clinics and the emergency clinics (DEGPs) in Oslo and Bergen, their health care needs, and the medical follow-up they are provided. The project will present new knowledge by showing trends in undocumented pregnant migrants care seeking compared to general trends among other migrants and Norwegian residents. It will also give new knowledge on pregnancy outcomes and perinatal health in undocumented migrants compared to foreign and Norwegian born women. This approach has not previously been used to study undocumented migrants in Norway, and there are very few similar studies in other European countries. Cause and effect relations are rarely claimed in findings from observational epidemiologic studies, however the information from three different sources (voluntary clinics, emergency clinics and Medical Birth Registry) will give an overall picture of the use of primary health care in undocumented pregnant migrants, as well as a comparative assessment of maternal outcomes in this population. The proposed research will also give important knowledge on how to conduct quantitative research in a population that is difficult to reach, and that is not commonly included in research.",[415,416,417],"Transients and Migrants","Primary Health Care","Pregnancy Outcome",[419,420,421],"Norway","Emergency care","Medical Birth Registry","2020-06-22",{"date":424,"type":33},"2020-06-25",{"date":426,"type":21},"2021-01",{"date":428,"type":21},"2028-02",{"name":39,"class":40},""]