[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Ostrava\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":135},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,77,106],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100640509","socket-preservation-using-autogenous-dentin-100640509",false,"NCT07608289","Socket Preservation Using Autogenous Dentin","Socket Preservation After Tooth Extraction Using Autogenous Dentin in Comparison With Other Techniques","SPAD","Inclusion Criteria:\n\n* 18-70 years\n* no active periodontitis\n* signed informed consent with participation in the study\n* need for extraction of teeth other than third molars\n* patients requesting only standard\u002Freimbursed care\n\nExclusion Criteria:\n\n* drug or alcohol abuse\n* ongoing chemotherapy\n* ongoing radiotherapy\n* pregnancy\n* ongoing treatment of osteoporosis or other biological treatment with MRONJ risk\n* low compliance\n* patients asking for premium care","ALL","18 Years","70 Years",{"count":21,"type":22},80,"ESTIMATED","INTERVENTIONAL",[25],"NA","Tooth extraction leads to a substantial reduction in alveolar bone volume, with up to 25% loss within the first year and up to 40-60% within three years. This prospective randomized clinical study aims to compare four commonly used methods of alveolar ridge preservation, evaluating their effectiveness in maintaining bone volume for later prosthetic or implant rehabilitation. Alveolar dimensions will be measured using calibrated CBCT imaging pre-extraction and at six months post-extraction.",[28],"Tooth Extraction Site Healing",[30,31,32,33],"Socket preservation","autogenous dentin","tooth extraction","alveolar ridge augmentation","RECRUITING","2026-05-20",{"date":37,"type":38},"2026-05-27","ACTUAL",{"date":40,"type":38},"2025-01-01",{"date":42,"type":22},"2028-12-31",{"name":44,"class":45},"University of Ostrava","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":4,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":69,"lastUpdatePostDateStruct":70,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":46},"100631020","prevalence-of-carotid-web-in-youth-100631020","NCT07495241","Prevalence of Carotid Web in Youth","Prevalence of Carotid Web in Youth Assessed by Duplex Sonography: a Cross-Sectional Study","CaWY","Inclusion Criteria:\n\n* Male or female\n* Age 15 - 25 years at enrollment\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Prior carotid endarterectomy and\u002For angioplasty and stenting\n* Neck irradiation\n* Known vasculopathy with non-web lesions that preclude assessment",true,"15 Years","25 Years",{"count":59,"type":22},829,"OBSERVATIONAL","A carotid web (CaW) is a shelf-like, thin, triangular endoluminal projection typically arising from the posterior wall of the internal carotid artery (ICA) bulb. CaW is considered by many to be an intimal variant of fibromuscular dysplasia and is associated with an increased risk of ischemic stroke in otherwise low-risk, younger patients. The CaWY study is a cross-sectional, multicenter, population-based sonographic survey with blinded central image adjudication, reported in accordance with STROBE guidelines for cross-sectional studies, aimed at estimating the prevalence of CaW detected by duplex sonography in the general population aged 15-25 years.",[63],"Carotid Web",[65,66,67,68],"Prevalence","Carotid artery","Carotid web","Duplex sonography","2026-03-22",{"date":71,"type":38},"2026-03-27",{"date":73,"type":38},"2026-01-04",{"date":75,"type":22},"2027-02-28",{"name":44,"class":45},{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":4,"eligibilityCriteria":83,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":84,"enrollmentInfo":85,"targetDuration":4,"studyType":23,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":104,"locationsCount":105},"100544859","small-bowel-diversion-100544859","NCT06374368","Small Bowel Diversion","Jejuno-Ileal and Jejuno-Colic Diversion as a New Bariatric Method in the Treatment of Diabetes and Obesity: Study Protocol for a Prospective Randomised Clinical Trial","Inclusion Criteria:\n\n* age 18-65 years at screening;\n* Body mass index ≥30 or ≤50kg\u002Fm2;\n* If subject has Type 2 Diabetes: fasting plasma glucose greater than 6,1 mmol\u002Fl at time of enrollment if not treated with anti-diabetic medication;\n* If on no diabetes medications, Hemoglobin A1C between and including 6.5 and 9.0 at time of enrollment.\n\nExclusion Criteria:\n\n* Body Mass Index \\>50 or \\\u003C30 kg\u002Fm2;\n* Diagnosis of Type 2 diabetes less than 6 months;\n* History of suspected gastrointestinal disease (for example cirrhosis, inflammatory bowel disease);\n* History of active malignancy (not in remission) with the exception of squamous or basal cell carcinoma of the skin;\n* Ongoing systemic infection;\n* Chronic pancreatitis;\n* Chronic liver disease of any cause;\n* Poorly controlled psychiatric disease (for example ongoing major depression, schizophrenia, borderline personality, suicidality, psychosis);\n* Any history of an eating disorder within the past 5 years;\n* Pre-existing severe comorbid cardio-respiratory disease (for example congestive heart failure, cardiac arrhythmia, coronary artery disease, chronic obstructive lung disease, pulmonary embolism);\n* uncontrolled hypertension (systolic Blood Preassure \\> 150 mm Hg or diastolic Blood Preassure \\> 100 mm Hg).","65 Years",{"count":21,"type":22},[25],"In an effort to replicate metabolic surgery's durable results in metabolic disease while minimizing its risks, two innovative methods has been created. Two surgical methods to create a bowel-to-bowel anastomosis, similar to the type used in current metabolic surgeries. It be to create a jejuno-ileal, side-to-side anastomosis and jejunocolic side-to-side anastomosis. The side-to-side jejuno-ileal anastomosis and side-to-side jejunocolic anastomosis provides two routes for ingested food. The new, shorter route has a malabsorptive effect similar to that seen in Roux en-Y gastric bypass (RYGB) and biliopancreatic diversion (BPD) - procedures which leads to weight loss. Additionally, delivery of non-absorbed macronutrients to the distal ileum, or transverse colon can enhance incretin effect and improve Type 2 Diabetes Mellitus parameters. However, the native route is also preserved, which theoretically reduces the risk of malnutrition, diarrhea, and metabolic derangements seen in other metabolic surgeries.The side-to-side jejuno-ileal anastomosis was already tested in the Pilot Study of the GI Windows Self-Forming Magnetic (SFM) Anastomosis Device for Creation of an Incisionless Small Bowel Bypass for Treatment of Obesity and Diabetes in year 2015 (15). The results of this study demonstrated the safety of this approach without serious adverse events. This non-surgical approach resulted in significant weight loss, favorable changes in insulin and incretin responses to a mixed meal and significant improvement in HbA1c in T2DM (16).In summary, metabolic diseases are a growing pandemic with suboptimal clinical solutions. The surgical side-to-side jejuno-ileal anastomosis and side-to-side jejuno-colic anastomosis without gastrectomy potentially represents a new class of therapy that may produce durable clinical results generally associated with surgery while minimizing its attendant risks.",[89,90],"Obesity","Type2 Diabetes",[89,92,93,94,95,96,97],"Type 2 Diabetes","Partial Jejunal Diversion","Partial Jejuno-colic Diversion","Bariatric surgery","Metabolic surgery","Side-to-Side Anastomosis","2025-08-13",{"date":100,"type":38},"2025-08-19",{"date":102,"type":38},"2019-05-01",{"date":42,"type":22},{"name":44,"class":45},2,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":112,"eligibilityCriteria":113,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":114,"targetDuration":4,"studyType":23,"phases":116,"briefSummary":117,"conditions":118,"keywords":120,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":127,"lastUpdatePostDateStruct":128,"startDateStruct":130,"completionDateStruct":132,"leadSponsor":134,"locationsCount":46},"100470164","sleep-disturbances-and-delirium-100470164","NCT05402280","Sleep Disturbances and Delirium","Sleep Disturbances in Hospitalized Patients as a Risk Factor for Delirium","SLEEP","Inclusion Criteria:\n\n* age over 18 years\n* a hospital stay longer than 24 hours\n* a hospital stay longer than 36 hours\n* hospitalized for at least 72 hours, without previous sleep disturbances, without cognitive impairment\n\nExclusion Criteria:\n\n* Patients with cognitive impairment preventing them from cooperating\n* Glasgow Coma Scale score below 12\n* terminal disease\n* previous and current treatment for sleep disturbances\n* neurocognitive dysfunction (dementia)\n* sedative administration over the last 24 hours",{"count":115,"type":22},3240,[25],"Delirium is a frequent and serious problem in hospitalized patients; it is associated with multiple hospital-acquired complications. There is evidence that the incidence of deliri-um may be minimized by multimodal interventions (pain management, shortening the duration of mechanical ventilation, light sedation, avoiding benzodiazepines, routine delirium monitoring, and early mobilization). Even though a clear association between sleep and delirium has not been established, many studies suggest that sleep disturban-ces may be a key risk factor for the development of delirium. Therefore, sleep promoti-on is becoming an integral part of clinical care. The project support the hypothesis that non-pharmacological preventive interventions promoting sleep (sleep protocol) positive-ly influence the quality of sleep and reduce the incidence of delirium in hospitalized patients. This will be verified by qualitative and quantitative research methods, with the quantitative study being divided into three prospective cross-sectional studies and one interventional study. Data will be obtained from 3240 hospitalized patients by combi-ning subjective methods (questionnaire surveys) and objective measurements (acti-graphy). The project outcomes will allow better understanding of the relationship betwe-en sleep and delirium. A set of non-pharmacological preventive interventions promoting sleep will be developed, with a subsidiary aim to potentially reduce the incidence of delirium in hospitalized patients.",[119],"Sleep Disturbance",[121,122,123,124,125,126],"sleep disruptions","delirium","inpatient","sleep protocol","actigraphy","interventions","2025-02-21",{"date":129,"type":38},"2025-02-25",{"date":131,"type":38},"2022-05-01",{"date":133,"type":22},"2025-12-31",{"name":44,"class":45},""]