[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Ottawa\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":671},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,26,0,25,[9,57,84,114,139,165,191,223,247,273,295,315,337,355,376,422,452,481,509,529,558,579,601,625,649],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":35,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":46,"lastUpdatePostDateStruct":47,"startDateStruct":50,"completionDateStruct":51,"leadSponsor":53,"locationsCount":56},"100644136","working-in-the-heat-at-simulated-altitude-effects-of-normobaric-hypoxia-on-physiological-strain-100644136",false,"NCT07664462","Working in the Heat at Simulated Altitude: Effects of Normobaric Hypoxia on Physiological Strain","Effects of Normobaric Hypoxia on Initial Stay Time and Physiological Strain During Moderate-Intensity Work in the Heat in Young and Older Males","Inclusion Criteria:\n\n* Are male.\n* Do not smoke or have been smoke free for at least 5 years.\n* English or French speaking.\n* Ability to provide informed consent.\n* Are physically active (engage in exercise at least 2 times per week for ≥30 minutes)\n\nExclusion Criteria:\n\n* Are regularly exposed to hot environments (e.g., occupational heat exposure)\n* Are regularly exposed to hypoxic environments (e.g., high altitudes)\n* Experience claustrophobia or discomfort in enclosed environments\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","MALE","18 Years","70 Years",{"count":21,"type":22},20,"ESTIMATED","INTERVENTIONAL",[25],"NA","Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers performing physically demanding work in hot environments. Current occupational heat-stress guidelines aim to limit excessive increases in core body temperature and physiological strain through the use of work-rest schedules. However, these guidelines do not provide clear direction on the safe, maximum duration of continuous work that can be performed before heat-mitigation controls should be implemented, known as the initial stay time. Recent work has generated initial stay time recommendations for young and older workers performing moderate-intensity work in the heat, but these estimates were developed under normoxic conditions. In many occupational settings, workers may be exposed to additional environmental stressors such as hypoxia, including work at altitude or in oxygen-reduced environments. Hypoxia can increase cardiovascular strain, reduce arterial oxygen saturation, and alter exercise tolerance, potentially compromising the effectiveness of heat-stress guidance developed under normal oxygen conditions. Older workers may be especially vulnerable due to age-related reductions in thermoregulatory and cardiovascular function. To date, it remains unclear whether hypoxia alters physiological strain during work in the heat or whether current initial stay time and recovery recommendations remain protective under combined heat and hypoxic stress.\n\nThe primary objective of this study is to determine whether exposure to hypoxia increases physiological strain during moderate-intensity work in the heat in young and older males. Specifically, investigators will assess whether normoxia-derived initial stay times and recovery recommendations for work at 29°C wet-bulb globe (37.5°C, 35% RH) temperature remain effective when workers are exposed to hypoxia equivalent to 14% inspired oxygen (simulating \\~3000 m in altitude). Healthy young and older males will complete simulated occupational heat exposure under two conditions: heat alone and combined heat plus hypoxia. Participants will perform moderate-intensity treadmill work based on age-specific initial stay times, followed by prescribed work-rest cycles and seated recovery. Measures of core temperature, cardiovascular strain, oxygen saturation, skin temperature, hydration status, perceptual responses, mood, symptoms of environmental stress, and cognitive function will be assessed to determine whether hypoxia modifies responses to work in the heat. This study will provide important evidence on whether occupational heat-stress guidance requires refinement when workers are exposed to combined heat and hypoxic stress.",[28,29,30,31,32,33,34],"Body Temperature Changes","Heat Stress","Heat Exposure","Heat Fatigue","Hypoxia, Altitude","Work Related Stress","Physiological Stress",[36,37,38,39,40,41,42,43,44],"Heat Strain","Thermoregulation","Exercise","Simulated altitude","Core temperature","Occupational Heat Stress","Aging","Hypoxia","Hyperthermia","RECRUITING","2026-06-17",{"date":48,"type":49},"2026-06-24","ACTUAL",{"date":46,"type":22},{"date":52,"type":22},"2027-02-28",{"name":54,"class":55},"University of Ottawa","OTHER",1,{"id":58,"slug":59,"hasResults":12,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":4,"eligibilityCriteria":63,"healthyVolunteers":64,"sex":17,"minAge":65,"maxAge":19,"enrollmentInfo":66,"targetDuration":4,"studyType":23,"phases":68,"briefSummary":69,"conditions":70,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":56},"100641555","consecutive-occupational-heat-exposure-with-and-without-overnight-cooling-100641555","NCT07656519","Consecutive Occupational Heat Exposure With and Without Overnight Cooling","Physiological Responses to Consecutive Days of Occupational Heat Exposure With and Without Overnight Access to Cooling","Inclusion Criteria:\n\n* Are male.\n* Do not smoke or have been smoke free for at least 5 years.\n* English or French speaking.\n* Ability to provide informed consent.\n* Are physically active (engage in exercise at least 2 times per week for ≥30 minutes)\n\nExclusion Criteria:\n\n* Are regularly exposed to hot environments (e.g., occupational heat exposure)\n* Experience claustrophobia or discomfort in enclosed environments\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening",true,"50 Years",{"count":67,"type":22},10,[25],"Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments. Current occupational heat-stress guidelines are designed to limit excessive increases in core body temperature and physiological strain during work in the heat through the use of work-rest schedules. However, these guidelines are largely based on single-day heat exposures and assume that workers recover in cool indoor environments between shifts. During heat events, many workers may instead recover in homes or accommodations that remain overheated, particularly in the absence of air conditioning. Inadequate overnight cooling may impair the body's ability to dissipate heat, increase physiological strain, and reduce tolerance to heat exposure on subsequent workdays. Older adults may be especially vulnerable due to age-related impairments in heat-loss capacity. To date, the effects of recovering in an overheated indoor environment on physiological strain and thermoregulatory function during repeated occupational heat exposure remain poorly understood, limiting the development of evidence-based recommendations to protect workers during prolonged heat events.\n\nThe primary objective of this study is to determine whether overnight recovery in an overheated indoor environment increases physiological strain during repeated occupational heat exposure in older adults. Specifically, investigators will assess whether recovery at the recently proposed upper indoor temperature limit of 26°C and 45% relative humidity (RH) (PMID: 38329752) is sufficient to attenuate elevations in core temperature during subsequent work in the heat compared with recovery in an overheated indoor environment (31°C, 45% RH) representative of conditions commonly experienced during extreme heat events. Healthy older adults will complete two consecutive days and nights of simulated moderate-intensity occupational heat exposure, with overnight recovery occurring in either the 26°C or 31°C condition. Measures of core temperature, cardiovascular strain, heat-loss capacity, hydration status, sleep quality, cognitive function, mood, and perceptual responses will be assessed to determine the impact of overnight recovery conditions on responses to repeated heat exposure. Whole-body heat-loss capacity will also be evaluated before and after the exposure protocol as assessed during incremental, intermittent exercise protocol performed in an air calorimeter.",[28,29,30,31,33,34],[36,37,38,40,72,42,73,74,44],"Occupational heat stress","Heat wave","Sleep","NOT_YET_RECRUITING","2026-06-14",{"date":78,"type":49},"2026-06-18",{"date":80,"type":22},"2026-07-01",{"date":82,"type":22},"2027-08-31",{"name":54,"class":55},{"id":85,"slug":86,"hasResults":12,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":4,"eligibilityCriteria":90,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":92,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":94,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":56},"100613515","suitability-of-a-26-c-indoor-environment-for-mitigating-heat-strain-in-young-adults-100613515","NCT07267598","Suitability of a 26 °C Indoor Environment for Mitigating Heat Strain in Young Adults","Evaluating the Effectiveness of a 26 °C Indoor Temperature Limit to Mitigate Physiological Strain in Young, Habitually Active Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* Healthy young adults without chronic disease (e.g., type 1 diabetes, hypertension)\n\nExclusion Criteria:\n\n* Endurance trained (i.e., engaged in regular physical training activities more than 3 times a week for more than 1 hour per session).\n* Undergoing passive heat exposures such as regular of saunas, warm-water immersion, other.\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Current pregnancy","ALL","29 Years",{"count":67,"type":22},[25],"While an indoor upper temperature limit of 26 °C has been shown to protect heat-vulnerable older adults (DOI: 10.1289\u002FEHP11651), this guideline has not been verified in young, habitually active adults. Public health recommendations during hot weather typically emphasize staying in cool environments, avoiding strenuous activity, wearing lightweight clothing, and maintaining adequate hydration. However, young adults may be less likely to follow these guidelines. They often do not reduce their physical activity during extreme heat events and may overdress for fashion, cultural, or religious reasons. These behaviors can impose an additional thermoregulatory burden and lead to greater physiological strain during heat exposure, even though young adults generally have a higher capacity for heat dissipation than older individuals. Accordingly, it is important to evaluate whether an indoor temperature limit of 26 °C is sufficient to protect young, habitually active adults.\n\nTo address this gap, the investigators aim to assess changes in body temperature and cardiovascular strain in young, habitually active adults (18-29 years) during an 8-hour exposure to the recommended indoor upper temperature limit of 26 °C and 45% relative humidity (humidex of 29, considered comfortable). Participants will complete two conditions:\n\nA) seated rest while dressed in light clothing (T-shirt, shorts, and socks), and B) light exercise (stepping to simulate activities of daily living, 4-4.5 METs) performed once per hour (except for the lunch hour) while dressed in light clothing plus an additional insulating layer (sweatshirt and sweatpants).\n\nThis experimental design will allow investigators to determine the effects of added clothing insulation and light activity-representative of typical daily behaviors-on physiological strain in young adults, and to assess whether refinements to the recommended 26 °C indoor temperature limit are warranted for this population.",[29,34,97],"Cognitive Change",[99,100,73,37,101,102,44,103,104,105],"Indoor overheating","Indoor temperatures","Heat strain","Heat vulnerability","Thermal comfort","Activities of daily living","Clothing insulation","2026-06-12",{"date":108,"type":49},"2026-06-16",{"date":110,"type":49},"2025-11-07",{"date":112,"type":22},"2026-12-30",{"name":54,"class":55},{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":64,"sex":121,"minAge":18,"maxAge":122,"enrollmentInfo":123,"targetDuration":4,"studyType":23,"phases":125,"briefSummary":126,"conditions":127,"keywords":129,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":133,"startDateStruct":134,"completionDateStruct":136,"leadSponsor":138,"locationsCount":56},"100606332","the-impact-of-wearing-the-hijab-on-whole-body-heat-loss-during-exercise-heat-stress-100606332","NCT07174180","The Impact of Wearing the Hijab on Whole-body Heat Loss During Exercise-heat Stress","The Effect of Wearing the Hijab on Dry and Evaporative Heat Exchange During Moderate-intensity Exercise Performed in Hot-dry Environments","Inclusion Criteria:\n\n* healthy young female (18-35 years)\n* non smoking\n* English or French speaking\n* ability to provide informed consent\n\nExclusion Criteria:\n\n* claustrophobia\n* engaged in endurance training\n* acute or chronic illness\n* sedentary (not engaged in any form of physical activity)\n* physical restriction limiting physical activity","FEMALE","35 Years",{"count":124,"type":22},12,[25],"The hijab (headscarf and cloak) is a Muslim dress, which covers the head, neck and chest, and conceals the female hair, leaving the face uncovered. It is worn by Muslim women worldwide including young Muslim women engaging in sports and exercise. As with any clothing worn on the body, the hijab can impact heat dissipation during exercise, potentially leading to increased body temperature and discomfort, especially in warmer environments. However, the extent to which the hijab may restrict heat loss remains unclear. This study aims to assess dry and evaporative heat exchange in young women performing moderate-intensity intermittent exercise in dry heat conditions (40°C, 15% relative humidity).",[29,128],"Temperature Change, Body",[40,38,130,131,101,37,132],"Females","Garment","Hot weather",{"date":108,"type":49},{"date":135,"type":49},"2025-06-13",{"date":137,"type":22},"2026-12-31",{"name":54,"class":55},{"id":140,"slug":141,"hasResults":12,"nctId":142,"briefTitle":143,"officialTitle":144,"acronym":145,"eligibilityCriteria":146,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":4,"enrollmentInfo":147,"targetDuration":4,"studyType":23,"phases":149,"briefSummary":150,"conditions":151,"keywords":154,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":157,"lastUpdatePostDateStruct":158,"startDateStruct":160,"completionDateStruct":162,"leadSponsor":164,"locationsCount":4},"100642487","post-concussion-sleep-and-brain-heart-functions-100642487","NCT07636408","Post-Concussion Sleep and Brain-heart Functions","Enhancing Sleep to Improve Brain-heart Functions in People With Persistent Post-concussion Symptoms","CBT-pI","Inclusion Criteria:\n\n1. Adults 18 years and older\n2. Experiencing persisting post-concussion symptoms \\> 4 weeks but no more than 12 months post-injury as measured based on home-made screening questions and the Sport Concussion Assessment Tool (SCAT6)\n3. Having a Sleep Condition Indicator score suggestive of insomnia (SCI =\u002F\\\u003C 15, adapted to enable the inclusion of insomnia symptoms over at least 1 month)\n4. Meeting diagnostic criteria for insomnia disorder on the SCID\n5. Having a smartphone, tablet or computer and willingness to install a sleep intervention application on it\n\nExclusion Criteria:\n\n1. Having undergone another CBT-I program within the past 6 months\n2. Current diagnosis of bipolar disorder, psychotic disorder, or substance use disorder confirmed by the M.I.N.I.\n3. Self-reported substance use disorder (i.e., alcohol, cannabis, or illicit drugs) or =\u002F\\> monthly use of illicit drugs reported on item-2 of the WHO-ASSIST (except tobacco, alcohol, and cannabis)\n4. Body mass index \\> 45\n5. Shift work or rotating shifts within 1 month of study entry\n6. Recent travel to a different time zone (leaving 1 week of recovery per time zone difference)\n7. Any clinically significant neurological disorder aside from concussion (including seizure disorder)\n8. Signs of sleep apnea as reflected by combined profiles on the Sleep Disorders Symptoms Checklist-25 and Epworth Sleepiness Scale\n9. Unstable psychotropic medications (need to be on a stable dose for at least 1 month prior to study start)\n10. Insufficient English skills to provide informed consent, understand study instructions, or fill out questionnaires",{"count":148,"type":22},70,[25],"This project is designed as a randomized controlled trial (RCT), with an active control group. Sleep and heart rate will be monitored at home for 1 week before and after the intervention. Questionnaires will be completed from home before, during and 8 weeks after the end of the Intervention. The Cognitive Behavioural Therapy for Insomnia, adapted for post-concussed individuals (CBT-pI) and control interventions, will be delivered on a digital online platform over an 8-week period. Participants in the control arm will be offered CBT-pI after the follow-up period. All intervention arms will be delivered as adjuncts to standard clinical care. All other treatments received during the intervention will be documented.",[152,153],"Insomnia","Concussion Post Syndrome",[155,156],"Cognitive Behavioral Therapy for Insomnia","digital therapy","2026-06-08",{"date":159,"type":49},"2026-06-11",{"date":161,"type":22},"2026-06",{"date":163,"type":22},"2027-04",{"name":54,"class":55},{"id":166,"slug":167,"hasResults":12,"nctId":168,"briefTitle":169,"officialTitle":170,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":64,"sex":121,"minAge":18,"maxAge":172,"enrollmentInfo":173,"targetDuration":4,"studyType":23,"phases":174,"briefSummary":175,"conditions":176,"keywords":178,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":183,"lastUpdatePostDateStruct":184,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":56},"100628271","postprandial-triglyceride-concentrations-across-menstrual-cycle-phases-100628271","NCT07459465","Postprandial Triglyceride Concentrations Across Menstrual Cycle Phases","Effect of Menstrual Cycle Phases on Postprandial Triglyceride Concentrations in Healthy Premenopausal Females: A Crossover Study","Inclusion Criteria:\n\n* English or French speaking\n* Ability to provide informed consent\n\nExclusion Criteria:\n\n* History or evidence of chronic disease\n* Current use of hypolipemic medication\n* Current use of hormonal contraceptives\n* Current use of antidepressants\n* Current use of anticoagulants\n* Ongoing smoking status\n* Experiencing pregnancy, puerperium, or irregular menstrual cycles","30 Years",{"count":124,"type":22},[25],"The goal of this clinical trial is to investigate the effect of menstrual cycle phases on postprandial triglyceride concentrations in healthy young female adults. The main question it aims to answer is: do postprandial triglyceride concentrations differ between the follicular and luteal phases of the menstrual cycle?\n\nParticipants will: visit the laboratory for a preliminary screening session to assess eligibility, and undergo two experimental sessions consisting of six hours of seated rest following the consumption of a high-fat meal (one session conducted in the early follicular phase, and one session conducted in the mid-luteal phase of the menstrual cycle).",[177],"Healthy Adult Females",[179,180,181,182],"Triglyceride","Postprandial Lipemia","High-Fat Meal","Menstrual Cycle","2026-05-14",{"date":185,"type":49},"2026-05-19",{"date":187,"type":49},"2026-03-26",{"date":189,"type":22},"2026-08-31",{"name":54,"class":55},{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":197,"eligibilityCriteria":198,"healthyVolunteers":12,"sex":121,"minAge":18,"maxAge":4,"enrollmentInfo":199,"targetDuration":4,"studyType":23,"phases":201,"briefSummary":202,"conditions":203,"keywords":207,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":214,"lastUpdatePostDateStruct":215,"startDateStruct":217,"completionDateStruct":219,"leadSponsor":221,"locationsCount":222},"100566825","biomodulation-and-rehabilitation-interventions-to-target-pelvic-health-100566825","NCT06660212","Biomodulation and Rehabilitation Interventions to tarGet Pelvic Health","Is Multimodal Physiotherapy and\u002For Photobiomodulation Therapy Effective for Pain Reduction Among Those Who Experience Provoked Vestibulodynia: a Randomized Controlled Trial","BRIGHT","Inclusion Criteria:\n\n* Willing to travel to Ottawa area or Quebec City area\n* Biologically born female older than eighteen years\n* Pre-menopausal\n* Not currently pregnant or pregnancy\u002Fgiven birth in the past six months\n* Experiencing signs and symptoms consistent with provoked vestibulodynia alone or provoked vestibulodynia plus vaginismus\n\nExclusion Criteria:\n\n* gynaecologist cannot insert a single digit intravaginally and thus the participant would be unlikely able to tolerate the assessment procedures\n* other gynaecologic conditions such as lichen sclerosus, fissures, endometriosis, adenomyosis, or pelvic organ prolapse",{"count":200,"type":22},240,[25],"This trial will provide evidence for the effective management of pain and pain-related domains among those who experience provoked vestibulodynia (PVD) using photobiomodulation (PBM) and multimodal physiotherapy (mPT) in a randomized controlled trial (RCT). PVD is the most common subcategory of vulvovaginal pain experienced during sexual and non-sexual activities, affects the psychological and sexual health of an astounding one in five Canadian women, yet access to evidence-informed management approaches is limited. We will employ four intervention groups: PBM, sham PBM (control), PBM combined with mPT, and mPT with sham PBM to evaluate the effectiveness of each approach on its own and the two approaches in combination.\n\nAmong those who experience PVD, we seek to answer:\n\n1. Relative to baseline and to sham PBM, does a 14-week intervention involving PBM, mPT, or a combination of mPT and PMB reduce vulvar pain severity reported on the Vulvar Pain Assessment Questionnaire (VPAQ)?\n2. Is a combined mPT and PBM intervention more effective than mPT or PMB alone when considering vulvar pain severity and\u002For related domains as measured through VPAQ?\n3. Are positive changes in vulvar pain severity and related domains observed following a 14-week intervention involving PBM, mPT or a combination of PBM and mPT retained at 6 months and at 1 year?\n\nSecondary objectives include determining the effectiveness of PBM, mPT, and mPT combined with PBM relative to sham PBM on: Patient Global Impression of Change (PGIC), pain sensitivity measured using provocative tests, the other domains of the VPAQ, sexual function, as well as investigating mediating effects of psychosocial variables (central sensitization index, chronic pain acceptance), gender identity, and the presence of vaginismus on patient response to mPT, PBM and mPT combined with PBM. Lastly we will monitor patient satisfaction with the interventions, adherence to the interventions, and any adverse events.",[204,205,206],"Vulvodynia","Provoked Vestibulodynia","Dyspareunia",[208,209,204,210,211,212,213],"Provoked vestibulodynia","Intervention","Double-blinded","Pelvic floor","laser","Vulvar pain","2026-04-28",{"date":216,"type":49},"2026-05-05",{"date":218,"type":49},"2025-03-17",{"date":220,"type":22},"2028-11",{"name":54,"class":55},2,{"id":224,"slug":225,"hasResults":12,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":4,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":230,"enrollmentInfo":231,"targetDuration":4,"studyType":23,"phases":233,"briefSummary":234,"conditions":235,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":239,"lastUpdatePostDateStruct":240,"startDateStruct":242,"completionDateStruct":244,"leadSponsor":246,"locationsCount":56},"100559194","synced---synchronized-eating-in-bipolar-depression-study-100559194","NCT06560957","SYNCED - SYNChronized Eating in Bipolar Depression Study","Feasibility and Acceptability of Adjunctive Time Restricted Eating in Bipolar Disorder: A Pilot Randomized Controlled Trial.","Inclusion Criteria:\n\n1. Be 18-55 years old\n2. Have a diagnosis of bipolar I or bipolar II disorder, confirmed by the Quick Structured Clinical Interview for DSM-5® Disorders, QuickSCID-5.\n3. Have depression symptoms as indicated by a score of ≥12 on MADRS and ≤12 on YMRS.\n4. Females of childbearing potential are willing to follow highly effective methods of contraception (mentioned below) for the duration of study\\*\n5. Participants must be able to speak, read, write and understand English or French.\n6. Be willing and able to provide informed consent.\n\nExclusion Criteria:\n\n1. Have any catatonic symptoms or eating disorder(s) as measured by the Quick Structured Clinical Interview for DSM-5® Disorders, QuickSCID-5.\n2. Have any unstable or inadequately treated neurological and medical conditions.\n3. Have had prior bariatric surgery. 4 Be taking hypoglycemia inducing medications.\n\n5\\. Be pregnant or lactating. 6. Currently taking any stimulant medications. 7. Be participating in any other diet or weight management program for the duration of the trial.\n\n8\\. Have any contraindication to fasting as judged by the assessing clinician. 9. Recently (i.e. within the past 8 weeks) began structured psychotherapy (i.e. cognitive-behavioral therapy, interpersonal psychotherapy, family-focused therapy, or interpersonal and social rhythm therapy).\n\n10\\. Have any other medical condition, substance use disorder or suicidal ideation for which physician or investigator team expresses concern about safety or ability to participate in the study.","55 Years",{"count":232,"type":22},40,[25],"Bipolar disorders (BD) are a group of complex disorders that impact mood, behaviour and cognition and are known to cause significant suffering and impairment. Circadian rhythm (your internal day\u002Fnight \"clock\") disruption, which can involve changes in sleep-wake cycles, frequently occurs in BD. Both depression and mania are accompanied by circadian disruption. These disruptions are hypothesized to lead to mood worsening, metabolic dysfunction and inflammation. If circadian dysfunction plays a significant role in the symptoms and trajectory of BD, then treatment approaches that target these functions may lead to better outcomes. One such approach is dietary interventions. Time restricted eating (TRE) is a dietary tool that restricts the eating to an 8-12 hour window, without changing diet quality or caloric intake. Studies involving time restricted eating have been done in other conditions with promising results. There have been no studies done for mood disorders in general or bipolar disorder specifically. In this proposal, the investigators will assess two dietary interventions (TRE and nutritional counselling) to examine how TRE may represent a safe and viable adjunct to traditional treatments. The investigators aim to compare TRE with nutritional counselling, while all participants continue to receive usual care. Participants will receive support from a registered dietician and will be instructed on dietary habits. Half of participants will receive nutritional counselling and half will be asked to do TRE. Those in the TRE group will be asked to select a 10-hour window to consume all food and non-water beverages for the 8-week period. Participants will be asked to complete a screening visit to determine eligibility, and then will complete questionnaires at baseline, week 4 and week 8 examining symptoms of their illness and cognition. Participants will also provide a blood sample at baseline and week 8 for standard biochemistry tests, pregnancy testing (if applicable), and to examine inflammatory markers. Participants will also wear an actigraphy watch which provides wireless continuous monitoring of movements and ambient light. The primary outcome is feasibility and acceptability (do people agree to participate, complete the study, and follow the intervention; what do they think of the intervention). Secondary outcomes include changes in depression, anxiety, sleep, and cognition. Exploratory outcomes include inflammatory markers and circadian disruption.",[236,237,238],"Bipolar Depression","Bipolar I Disorder","Bipolar II Disorder","2026-04-27",{"date":241,"type":49},"2026-05-01",{"date":243,"type":49},"2025-07-10",{"date":245,"type":22},"2027-02-26",{"name":54,"class":55},{"id":248,"slug":249,"hasResults":12,"nctId":250,"briefTitle":251,"officialTitle":252,"acronym":4,"eligibilityCriteria":253,"healthyVolunteers":64,"sex":121,"minAge":172,"maxAge":254,"enrollmentInfo":255,"targetDuration":4,"studyType":23,"phases":257,"briefSummary":258,"conditions":259,"keywords":262,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":266,"lastUpdatePostDateStruct":267,"startDateStruct":269,"completionDateStruct":270,"leadSponsor":272,"locationsCount":4},"100547253","physical-activity-for-adults-in-the-ontario-breast-screening-program-100547253","NCT06405568","Physical Activity for Adults in the Ontario Breast Screening Program","Support for Physical Activity for Adults Registered in the Ontario Breast Screening Program: A Randomized Controlled Trial","Inclusion Criteria:\n\n* English- and French-speaking adults enrolled in the Ontario Breast Screening Program;\n* Aged 30-69 years;\n* Assigned female sex at birth;\n* Be at high risk for breast cancer as identified through Category A or B, after genetic assessment: (a) Category A individuals meet ≥1 of the following criteria: (i) known carrier of a gene mutation (e.g., BRCA1, BRCA2), (ii) first degree relative of a carrier of a gene mutation (e.g., BRCA1, BRCA2), received genetic counselling but declined genetic testing, (iii) previously assessed as having ≥25% lifetime risk of breast cancer on basis of family history, or (iv) received chest radiation before age 30 and ≥ 8 years previously.\n\n  (b) Category B individuals meet ≥1 of the following criteria: (i) first degree relative of a carrier of a gene mutation (e.g., BRCA1, BRCA2), has not had genetic counselling or testing, (ii) a personal or family history of ≥1 of the following: ≥2 cases of breast cancer and\u002For ovarian cancer in closely related blood relatives, bilateral breast cancer, both breast cancer and ovarian cancer in the same individual, breast cancer at age ≤35 years, invasive serous ovarian cancer, breast cancer and\u002For ovarian cancer in Ashkenazi Jewish families, an identified gene mutation (e.g., BRCA1, BRCA2) in any blood relative, male breast cancer.\n\nExclusion Criteria:\n\nIndividuals self-reporting\n\n* \\>150 minutes of moderate-to-vigorous intensity physical activity in the past week;\n* no access to an internet connected device;\n* a condition preventing physical activity (e.g., uncontrolled hypertension)","69 Years",{"count":256,"type":22},200,[25],"There is \"strong\" evidence that physical activity (PA) can reduce the risk of breast cancer (Bernstein, 2009; Kehm et al., 2020), which is important for individuals at higher-than-average risk due to their family history or genetic susceptibility. PA can also enhance quality of life (QoL), fitness, and surrogate markers (e.g., weight) linked to cancer prognosis (Ligibel et al., 2019; Patel et al., 2019). Despite this evidence, most adults are insufficiently active, meaning they do not meet Canadian recommendations of at least 150 minutes of PA each week (Statistics Canada, 2020). This study aims to develop materials that can help increase the number of adults at higher-than-average risk who meet PA recommendations, alongside improving QoL and body mass index (BMI; a measure of one's body weight-height ratio). Participants will include individuals assigned female at birth, aged 30-69 years, at high-risk of breast cancer registered in the Ontario Breast Screening Program who will be randomly assigned to receive (1) the intervention, which includes a copy of PA recommendations (Canadian Society for Exercise Physiology \\[CSEP\\] recommendations for adults plus content spotlighting PA benefits) plus a PA motivation package featuring three online webinars (explaining PA benefits and how to get started), digitized PA materials (providing evidence-based tools to modify behaviour), and a digitized logbook (to track PA) or (2) only a copy of PA recommendations.",[260,261],"Breast Cancer Female","Physical Inactivity",[263,264,265],"Healthcare providers","Physical activity","Breast cancer","2026-04-23",{"date":268,"type":49},"2026-04-29",{"date":241,"type":22},{"date":271,"type":22},"2028-05-01",{"name":54,"class":55},{"id":274,"slug":275,"hasResults":12,"nctId":276,"briefTitle":277,"officialTitle":278,"acronym":4,"eligibilityCriteria":279,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":280,"enrollmentInfo":281,"targetDuration":4,"studyType":23,"phases":282,"briefSummary":283,"conditions":284,"keywords":285,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":292,"leadSponsor":294,"locationsCount":56},"100622415","heat-stress-in-individuals-with-schizophrenia-100622415","NCT07383324","Heat Stress in Individuals With Schizophrenia","Impact of Indoor Overheating on Physiological Strain in Individuals With Schizophrenia","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed consent.\n* Individuals with and without schizophrenia or schizoaffective disorder.\n\nExclusion Criteria:\n\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity\n* Any history of diagnoses for other psychiatric disorders deemed to make participation in the study inadvisable.","85 Years",{"count":67,"type":22},[25],"Schizophrenia is a severe mental illness affecting approximately 24 million people worldwide and is associated with more than double the all cause mortality risk of the general population. Emerging evidence demonstrates that elevated temperatures acutely worsen mental health symptoms and significantly increase the risk of heat related morbidity and mortality. For people living with schizophrenia, prolonged exposure to heat can exacerbate psychiatric symptoms, impair judgment and decision making, and reduce the ability to engage in protective behaviors such as increasing hydration, reducing clothing, improving ventilation, or seeking cooler environments. As a result, individuals with schizophrenia may experience higher rates of heat related illness. To date our understanding of heat exposure effects in individuals with schizophrenia remains incomplete, hindering the development of evidence-based strategies to protect them.\n\nThus, the primary objective of this exploratory study is to gather preliminary data on the effects of indoor overheating on physiological responses (core body temperature and cardiovascular function), cognitive performance (attention, working memory, and reaction time), and mood in adults with schizophrenia. Specifically, we will assess whether maintaining indoor conditions at the upper recommended temperature limit for older adults (26°C, 45% relative humidity \\[RH\\]; PMID: 38329752) is sufficient to mitigate physiological strain compared with exposure to a hot indoor environment (36°C, 45% RH) representative of non-air-conditioned homes during extreme heat events in individuals with schizophrenia. In both conditions, the individual will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (4-4.5 METS) each hour (excluding the lunch period) to reflect typical daily activities of daily living.",[29,34,97],[99,100,73,37,286,101,102,44,287,103,264],"Schizophrenia","Mental health","2026-04-20",{"date":266,"type":49},{"date":291,"type":49},"2025-11-08",{"date":293,"type":22},"2027-07-01",{"name":54,"class":55},{"id":296,"slug":297,"hasResults":12,"nctId":298,"briefTitle":299,"officialTitle":300,"acronym":4,"eligibilityCriteria":301,"healthyVolunteers":64,"sex":91,"minAge":302,"maxAge":303,"enrollmentInfo":304,"targetDuration":4,"studyType":23,"phases":305,"briefSummary":306,"conditions":307,"keywords":308,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":311,"startDateStruct":312,"completionDateStruct":313,"leadSponsor":314,"locationsCount":56},"100613024","impact-of-indoor-overheating-on-physiological-strain-in-children-100613024","NCT07261202","Impact of Indoor Overheating on Physiological Strain in Children","A Preliminary Study Assessing the Effectiveness of a 26 °C Indoor Temperature Limit on Physiological Responses in Children","Inclusion Criteria:\n\n* English or French speaking.\n* Ability to provide informed assent.\n\nExclusion Criteria:\n\n* Chronic health conditions\n* Endurance exercise training (greater than 3 sessions of vigorous exercise training per week for 30 minutes or more)\n* Restrictions to physical activity","10 Years","15 Years",{"count":67,"type":22},[25],"Communities worldwide are experiencing increasing heat extremes that challenge the limits of human thermoregulation, particularly among vulnerable populations such as children. Compared with adults, children are more susceptible to heat related illness due to less efficient thermoregulatory systems and difficulty recognizing early signs of heat stress. In addition, prolonged heat exposure can adversely affect their mental health, contributing to cognitive decline, heightened anxiety, and irritability. As children spend substantial time in hot environments at school and at home, and as these conditions intensify with climate change, actions to safeguard their health are essential. Yet our understanding of heat exposure effects in children remains incomplete, hindering the development of evidence based strategies to protect them.\n\nTo address this gap, the investigators aim to evaluate whether an indoor temperature limit of 26 °C (45 percent relative humidity), the upper threshold recommended to protect older adults, can effectively prevent dangerous increases in physiological strain and declines in cognitive function in children during a simulated daylong heatwave. The preliminary study will assess physiological and cognitive responses in children aged 10 to 15 years during a 6 hour exposure (approximating a typical school day) to two conditions: (1) the recommended indoor temperature upper limit (26 °C) and (2) a high heat condition representative of homes and schools without air conditioning during extreme heat events (36 °C). In both conditions, children will remain seated at rest while wearing light clothing (t shirt and shorts), with the exception of performing 15 minutes of stepping exercise (6-6.5 METS) each hour (excluding the lunch period) to reflect typical daily activity in a school setting. This experimental design will allow investigators to determine whether maintaining indoor temperatures at the recommended upper limit for older adults sufficiently mitigates physiological strain in children.",[29,34,97],[99,100,73,37,309,101,102,44,310,103,264],"Adolescent","Youth",{"date":266,"type":49},{"date":291,"type":49},{"date":137,"type":22},{"name":54,"class":55},{"id":316,"slug":317,"hasResults":12,"nctId":318,"briefTitle":319,"officialTitle":320,"acronym":4,"eligibilityCriteria":321,"healthyVolunteers":64,"sex":91,"minAge":322,"maxAge":280,"enrollmentInfo":323,"targetDuration":4,"studyType":23,"phases":324,"briefSummary":325,"conditions":326,"keywords":327,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":331,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":56},"100607511","suitability-of-the-26-c-indoor-temperature-upper-limit-for-older-adults-impacts-of-clothing-and-daily-activity-100607511","NCT07189507","Suitability of the 26 °C Indoor Temperature Upper Limit for Older Adults: Impacts of Clothing and Daily Activity","Evaluation of the 26 °C Indoor Temperature Upper Limit Considering Clothing Insulation and Daily Activity in Older Adults","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis\n\nExclusion Criteria:\n\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to your diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","65 Years",{"count":67,"type":22},[25],"While an upper limit of 26°C has been shown to be protective for heat-vulnerable older occupants (DOI: 10.1289\u002FEHP11651), this recommendation did not consider the added heat burden associated with increases in internal heat production accompanying activities of daily living or the restriction to heat loss caused by clothing insulation. To safeguard the health of older adults, health agencies worldwide recommend the remain in cool space indoors, avoid strenuous activity, wear lightweight clothing, and drink cool water regularly throughout the day. However, older adults do not sense heat as well as their younger counterparts. Consequently, they may not take appropriate countermeasures to mitigate physiological strain from indoor overheating. This may include overdressing despite high indoor temperatures. In other cases, individuals may wear insulated clothing in hot weather to observe cultural or religious modesty requirements, which serve as expressions of faith and identity rather than a tool for thermoregulation. Further, individuals may be unaware of the consequences of increases in physical activity on heat gain and may therefore not adjust their normal day-to-day activity levels to prevent potentially dangerous rises in body temperature. Consequently, this may necessitate a lowering of recommended upper indoor temperature limit during hot weather.\n\nTo address these important considerations, on separate occasions the investigators will assess the change in body temperature and cardiovascular strain in older adults (65-85 years) exposed for 8 hours to the recommended indoor temperature upper limit of 26°C and 45% relative humidity equivalent humidex of 29 (considered comfortable) while they A) perform seated rest dressed in light clothing (t-shirt, shorts and socks), B) perform light exercise (stepping exercise to simulate activities of daily living, 4-4.5 METS) every hour (except during lunch hour period) dressed in light clothing, C) perform light exercise (4-4.5 METS) every hour (except during lunch hour period) dressed in light clothing (t-shirt, shorts and socks) and an added clothing layer (sweatshirt and sweatpants) and D) perform seated rest dressed in light clothing (t-shirt, shorts and socks) and an added clothing layer (sweatshirt and sweatpants). With this experimental design, investigators will assess the effects of added clothing insulation and light activity, representative in activities of daily living on physiological strain and identify whether refinements in the recommended 26°C indoor temperature limit may be required.",[29,34],[99,100,73,37,101,102,44,328,103,329,330],"Elderly","Clothing","Activity",{"date":266,"type":49},{"date":333,"type":49},"2025-09-23",{"date":335,"type":22},"2027-03-31",{"name":54,"class":55},{"id":338,"slug":339,"hasResults":12,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":23,"phases":345,"briefSummary":346,"conditions":347,"keywords":4,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":349,"lastUpdatePostDateStruct":350,"startDateStruct":351,"completionDateStruct":352,"leadSponsor":354,"locationsCount":4},"100634979","exercise-training-for-people-with-advanced-multiple-sclerosis-100634979","NCT07546721","Exercise Training for People With Advanced Multiple Sclerosis","Exercise Training for People With Advanced Multiple Sclerosis: A Feasibility Study to Inform Intervention Development","Inclusion Criteria:\n\n* ≥18 years of age\n* Self-reported diagnosis of MS\n* Expanded Disability Status Score ≥ 7.0\n* Stable course of disease-modifying therapy over past six months\n* Physician approval for exercise participation\n\nExclusion Criteria:\n\n* Diagnosis of other neurological conditions\n* Relapse within 30 days\n* Signs or symptoms of acute or uncontrolled cardiovascular, renal or metabolic disease or other conditions that make it unsafe to exercise\n* Currently engaging in regular aerobic exercise (≥ 2 sessions\u002Fweek for ≥ 12 weeks)\n* Additional exclusion criteria for functional electrical stimulation (FES) cycling exercise are cardiac demand pacemakers, implanted defibrillators, unhealed fractures, pregnancy, epilepsy, autonomic dysreflexia, and acute infections",{"count":124,"type":22},[25],"The goal of this interventional study is to test the feasibility of 12 weeks of aerobic exercise for people with advanced multiple sclerosis (i.e., wheelchair users). The main questions it aims to answer are:\n\n* Is the exercise intervention feasible in terms of study processes, resources, management, safety, and acceptability?\n* Can the intervention improve aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, and sensation?\n* What are participants' experiences of taking part in the exercise intervention?\n\nParticipants will take part in moderate-intensity aerobic exercise twice a week for 12 weeks in a supervised research setting. Outcomes will be measured at baseline (0 weeks), mid-intervention (6 weeks), post-intervention (12 weeks), and 12-weeks after the intervention (24 weeks). The outcomes include feasibility measures, aerobic fitness, function in daily life, cognition, symptoms of fatigue and pain, sensation, and participant experiences of taking part in the exercise intervention.",[348],"Multiple Sclerosis","2026-04-16",{"date":266,"type":49},{"date":241,"type":22},{"date":353,"type":22},"2027-06-01",{"name":54,"class":55},{"id":356,"slug":357,"hasResults":12,"nctId":358,"briefTitle":359,"officialTitle":359,"acronym":4,"eligibilityCriteria":360,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":4,"enrollmentInfo":361,"targetDuration":4,"studyType":23,"phases":363,"briefSummary":364,"conditions":365,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":375},"100544395","effect-of-community-choir-singing-in-people-with-chronic-post-stroke-aphasia-100544395","NCT06368323","Effect of Community Choir Singing in People With Chronic Post-stroke Aphasia","Inclusion Criteria:\n\n* People with chronic aphasia following stroke\n* English or French as language of daily use\n* Last stroke must have occurred at least 6 months before the start of the first assessments in the study protocol.\n\nExclusion Criteria:\n\n* Regular music making in the past 6 months\n* Visual deficit that cannot be corrected and might impair testing\n* Hearing deficit that cannot be corrected and might impair testing\n* Presence of neurological\u002Fpsychiatric co-morbidity or substance abuse\n* No ability to produce vocal sound through singing\u002Fhumming\n* Legally considered unable to make decisions for oneself",{"count":362,"type":22},50,[25],"The goal of this randomized controled trial is to test the effects of assigning people with chronic post-stroke aphasia to 12 weekly choir sessions, compared to usual care.\n\nThe main question it aims to answer is:\n\nDoes the assignment to a choir singing program causes a beneficial effect on functional communication and language recovery as well as psychosocial outcomes compared to usual care in the rehabilitation of people with chronic post-stroke aphasia?\n\nParticipants will have:\n\n12 in-person choir-singing sessions (1 session\u002Fweek, 1,5 h\u002Fsession, total 18h) conducted by a choir master, and home singing training (3 x 30-minutes-sessions\u002Fweek, total 18h)",[366],"Aphasia","2026-02-12",{"date":369,"type":49},"2026-02-17",{"date":371,"type":49},"2024-04-22",{"date":373,"type":22},"2027-09-30",{"name":54,"class":55},4,{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":64,"sex":121,"minAge":18,"maxAge":384,"enrollmentInfo":385,"targetDuration":4,"studyType":387,"phases":4,"briefSummary":388,"conditions":389,"keywords":394,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":414,"lastUpdatePostDateStruct":415,"startDateStruct":417,"completionDateStruct":419,"leadSponsor":421,"locationsCount":56},"100607072","trampoline-induced-changes-in-pelvic-structure-and-continence-100607072","NCT07183800","Trampoline-Induced Changes in Pelvic Structure and Continence","Does a 10-minute Trampoline Protocol Induce Urine Leakage or Changes in Pelvic Morphometry Among Females Who Report That They do Not Experience Symptoms of Urinary Incontinence?","TRAM","Inclusion Criteria:\n\n* Aged 18-40\n* Engage in regular physical activity or sport\n* Do not experience frequent urinary leakage (no more than once per month during exercise, coughing, or sneezing)\n* Can complete a 10-minute jumping protocol\n\nExclusion Criteria:\n\n* Currently pregnant or have been pregnant in the past 6 months\n* Have cardiac, pulmonary, metabolic, and\u002For neurological conditions\n* Have a lower body injury that limits your ability to jump\n* Have had a hysterectomy and\u002For incontinence surgery","40 Years",{"count":386,"type":22},30,"OBSERVATIONAL","The goal of this clinical trial is to evaluate whether a short bout of high-intensity trampoline jumping induces urinary leakage or measurable changes in pelvic floor morphology in active females aged 18-40 who do not report symptoms of urinary incontinence. The main questions it aims to answer are:\n\nHypothesis 1: Does a single 10-minute trampoline protocol result in acute changes in pelvic floor structure, including bladder neck position, levator plate length, and\u002For posterior urethrovesical angle (PUVA)?\n\nHypothesis 2: Do participants report any urinary leakage during the jumping protocol, despite being asymptomatic at baseline?\n\nHypothesis 3: Do pelvic morphology changes recover within 30 minutes post-jumping, or do alterations persist?\n\nResearchers will perform within-subject comparisons at multiple time points (pre-jump, immediately post-jump, and 30 minutes post-jump) using transperineal ultrasound imaging to assess structural changes.\n\nParticipants will:\n\n* Attend one laboratory visit\n* Complete baseline pelvic health questionnaires (ICIQ-UI Short Form and PFD Sentinel).\n* Undergo 2D transperineal ultrasound imaging in the standing position at rest, immediately post-jumping, and 30 minutes post-jumping.\n* Perform a 10-minute high-intensity jumping protocol on a mini-trampoline, while heart rate and perceived exertion are monitored.\n* Verbally report any urine leakage during jumping using standardized descriptors.",[390,391,392,393],"Urinary Continence","Urinary Incontinence","Urinary Incontinence (UI)","Urinary Incontinence , Stress",[395,396,397,398,399,400,401,402,403,404,405,406,407,408,409,410,411,412,413],"stress urinary incontinence","pelvic floor","pelvic floor morphology","high impact exercise","urine leakage","urinary symptoms","levator plate","female athletes","bladder neck","posterior urethro-vesical angle","PUVA","jump","trampoline","high impact","high intensity","healthy female","incontinence","leakage","urinary leakage","2025-09-29",{"date":416,"type":49},"2025-10-03",{"date":418,"type":49},"2025-07-16",{"date":420,"type":22},"2026-04-30",{"name":54,"class":55},{"id":423,"slug":424,"hasResults":12,"nctId":425,"briefTitle":426,"officialTitle":427,"acronym":428,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":91,"minAge":18,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":23,"phases":432,"briefSummary":433,"conditions":434,"keywords":440,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":444,"lastUpdatePostDateStruct":445,"startDateStruct":447,"completionDateStruct":449,"leadSponsor":451,"locationsCount":56},"100583170","adapting-the-fear-of-recurrence-therapy-fort-for-parents-and-establishing-acceptability-and-feasibility-100583170","NCT06872840","Adapting The Fear Of Recurrence Therapy (FORT) for Parents and Establishing Acceptability and Feasibility","Addressing Fear of Cancer Recurrence in Parents of Pediatric Cancer Survivors: Adapting The Fear Of Recurrence Therapy (FORT) for Parents and Establishing Acceptability and Feasibility","Parent-FORT","Inclusion Criteria:\n\n* Parent (or primary caregiver) caring for a childhood cancer survivor (\\\u003C18 years of age) of any type of cancer type, who is at least 1 months from the completion of active treatment and has not had a recurrence of their cancer\n* A score of 13 or greater on the Fear of Cancer Recurrence Inventory-Short Form-Parent version (FCRI-SF-P; range 0-36), suggesting clinical levels of FCR\n* Access to a computer and internet connection\n* Living in Canada\n\nExclusion Criteria:\n\n* Being the parent of a pediatric cancer survivor who is now 18 years of age or older\n* Being the parent of a pediatric cancer survivor who has undergone hematopoietic cell transplantation and has active chronic or acute graft-versus-host disease which has not stabilized for at least 3 months\n* Non-English speakers\n* Currently participating in another therapist-led psychosocial therapy group\n* Parent with unmanaged\u002Fundermanaged mental health disorder judged to be clinically contraindicated and\u002For likely to affect the group work\n* To avoid violating the assumption of nonindependence of the data, only one parent\u002Fcaregiver per child can participate in the study.",{"count":431,"type":22},36,[25],"Clinical levels of fear of cancer recurrence (FCR) affect up to 59% of adult cancer survivors. Family caregivers experience equal or greater levels of FCR, which has been linked to lower quality of life and increased distress. FCR can be addressed in cancer survivors with brief interventions. However, none of these interventions have been tested with parents of childhood cancer survivors. This is an urgent gap: the survival rates of childhood cancer have increased more rapidly than for adult cancers, resulting in a growing population of childhood cancer survivors who, along with their families, need support.\n\nThe goals of this pilot study are to demonstrate 1) that a newly adapted intervention of FORT (Parent-FORT) is feasible (i.e., participant recruitment, attendance and participation) and acceptable (i.e., parent satisfaction of the intervention) for a larger study, and 2) the clinical implications of Parent-FORT on fear of cancer recurrence (FCR) and quality of life in parents of childhood cancer survivors.\n\nParents will be randomly assigned to participate in the Parent-FORT intervention immediately or a three-month waitlist control group. They will complete a questionnaire package before and after the intervention, as well as at a three month follow up. This study will help bridge an important gap in bringing evidence-based care to parents who have never been offered help before for their FCR.",[435,436,437,438,439],"Cancer","Parent","Fear of Cancer Recurrence","CBT","Childhood Cancer Survivors",[441,442,443],"Pilot study","Group Therapy","Virtual","2025-09-16",{"date":446,"type":49},"2025-09-22",{"date":448,"type":49},"2025-08-26",{"date":450,"type":22},"2027-05-26",{"name":54,"class":55},{"id":453,"slug":454,"hasResults":12,"nctId":455,"briefTitle":456,"officialTitle":457,"acronym":458,"eligibilityCriteria":459,"healthyVolunteers":12,"sex":121,"minAge":18,"maxAge":4,"enrollmentInfo":460,"targetDuration":4,"studyType":23,"phases":461,"briefSummary":462,"conditions":463,"keywords":465,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":473,"lastUpdatePostDateStruct":474,"startDateStruct":476,"completionDateStruct":478,"leadSponsor":480,"locationsCount":56},"100600874","managing-impact-related-leakage-during-exercise-using-intravaginal-support-100600874","NCT07103161","Managing Impact-related Leakage During Exercise Using Intravaginal Support","Does a Regular Tampon or Intravaginal Pessary Mitigate Urine Leakage While Running Among Females Who Experience Exercise-induced Urinary Incontinence?","MILES","Inclusion Criteria:\n\n* Age \\>18 years of age\n* Participate in any exercise or sport modality involving running or brisk walking\n* Experiences urine leakage during running or brisk walking\n* Speak and read English or French\n\nExclusion Criteria:\n\n* No urine leakage in the first laboratory assessment (baseline \u002F no intervention)\n* Currently pregnant or have been pregnant in the previous 6 months\n* Had or have had cardiac, pulmonary, metabolic and\u002For neurological conditions\n* History of incontinence surgery\n* Hysterectomy\n* Symptoms consistent with urgency incontinence only\n* Experience pain with tampon use or during gynecologic examinations",{"count":386,"type":22},[25],"The goal of this study is to evaluate the effectiveness of using a regular menstrual tampon or a Uresta pessary to reduce urine leakage associated with running-induced stress urinary incontinence (RI-SUI) in females aged 18 and older. Secondly, the study aims to assess whether either intervention mitigates transient changes in pelvic morphology that occur following a single running bout. Lastly, we aim to evaluate whether participants continue using either intervention during running over the 4-week period following their in-lab participation. The hypotheses are:\n\nHypothesis 1: Among females with RI-SUI, both a tampon and pessary used during a single running bout will reduce urinary leakage symptoms, with greater symptom reduction observed when using the pessary.\n\nHypothesis 2: Participants will report high satisfaction and perceived symptom improvement with both the tampon and pessary, with higher satisfaction and greater improvement reported for the pessary.\n\nHypothesis 3: Both the tampon and pessary will reduce pelvic floor strain incurred by the end of the run, as evidenced by less bladder neck descent, levator plate lengthening, and levator hiatus area increasing relative to that observed when no tampon or pessary is used.\n\nHypothesis 4: A greater proportion of participants will report continued use of the pessary compared to the tampon over the 4-week post-lab period, with higher frequency of use and fewer reported discontinuations.\n\nWe will perform within-subject comparisons against baseline values to determine the effect of each intervention on RI-SUI symptoms and pelvic organ support.\n\nParticipants will complete a baseline questionnaire to collect demographic information and assess incontinence severity. They will then attend three laboratory visits within a 10-day period. At each visit, bladder volume will be standardized to between 100 and 200mL, then the participant will undergo three-dimensional (3D) transperineal ultrasound imaging conducted in a standing position. Following imaging, participants will complete a treadmill protocol consisting of 25-minutes running at a moderately difficult pace (rated at 13 - 14 on the Borg Perceiver Rate of Exertion scale), followed by 5 minutes of running at a higher intensity pace. During the run, participants will be asked at 5 minute intervals whether they experienced any urine leakage and to report their perceived amount of leakage. The ultrasound image protocol will be repeated immediately after the run.\n\nParticipants will be allowed to keep the pessary and will be contacted 4-weeks after the final visit to evaluate whether or not they continued use of a tampon or the pessary, and, if so, we will ask them to report their satisfaction with the intervention(s) they used.",[464],"Stress Urinary Incontinence (SUI)",[395,466,467,468,469,400,470,399,471,472],"conservative treatment","pelvic floor strain","pessary","bladder support device","tampon","urine leakage with exercise","urine leakage with running","2025-07-31",{"date":475,"type":49},"2025-08-05",{"date":477,"type":49},"2022-09-13",{"date":479,"type":22},"2026-03",{"name":54,"class":55},{"id":482,"slug":483,"hasResults":12,"nctId":484,"briefTitle":485,"officialTitle":486,"acronym":4,"eligibilityCriteria":487,"healthyVolunteers":64,"sex":91,"minAge":18,"maxAge":4,"enrollmentInfo":488,"targetDuration":4,"studyType":23,"phases":490,"briefSummary":491,"conditions":492,"keywords":494,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":508,"locationsCount":56},"100599687","improving-patient-mental-health-with-psychotherapist-virtual-training-100599687","NCT07087730","Improving Patient Mental Health With Psychotherapist Virtual Training","Improving Patient Mental Health With Psychotherapist Virtual Training: A Practice- Research Network Study","Inclusion Criteria:\n\n* Therapist participants: The investigators will recruit mental health professionals who deliver psychotherapy in North American community settings; inclusion criteria: therapists are in good standing with their provincial or state regulatory college, their scope of practice includes individual psychotherapy for adults in North America; they are able to accept a minimum of 3 new participating patients into their current practice to conduct 6 consecutive therapy sessions via a secure, PHIPA compliant virtual meeting platform.\n* Patient Participants: Adults (\\> 18 years) residing in Canada or the United States who want to engage in therapy with a study therapist or who have recently sought services from a study therapist; inclusion criteria: have participated in fewer than 3 sessions with their study therapist and anticipate being able to see their study therapist for 6 sessions over the next 6 months.\n\nExclusion Criteria:\n\n* Therapist participants: The investigators will exclude therapists who are employed by an organization if the investigators cannot obtain organizational approval from their employer or coordinate data collection from an alternate virtual platform in instances where the employing organization does not permit the use of the study platform. Therapists will also be excluded if they have completed professional development workshop after 2017 with PPRNet.\n* Patient participants: The investigators will exclude patients if they: (a) have a psychotic or neurocognitive disorder that may preclude engagement in psychotherapy, (b) are in concurrent psychological treatment with another practitioner, (c) are at high risk of suicide or suicidal behaviors as assessed by their therapist (e.g., suicide attempt or hospitalization for suicidal behaviors in the past 6 months), or (d) for whom the therapist judge that approaching them with information about the study will be harmful.",{"count":489,"type":22},489,[25],"Several types of psychotherapy are equally effective to treat mental disorders. However, many patients remain symptomatic after treatment. The investigators demonstrated that a professional development training program to improve psychotherapists' skills at identifying and repairing therapeutic alliance tensions resulted in improved therapeutic alliance (an important therapeutic ingredient) and patient mental health outcomes. However, the investigators delivered this training program by conventional in-person workshops which limited access by psychotherapists living outside large urban centres. Further, post-study interviews with therapists suggested that cultural\u002Fdiversity factors complicated the therapeutic alliance.\n\nIn the current study, the investigators will test the effectiveness and acceptability of a virtually-delivered training program to psychotherapists in North America to improve their capacity to identify and repair problems in the therapeutic alliance, including tensions related to patient diversity. The investigators will also examine how acceptable the virtually-delivered training is to psychotherapists and whether they would use such training in their practice. Participants in the study will be community-based licensed psychotherapists and their patients engaging in therapy in North America. Patient mental health outcomes, therapeutic alliance, and diversity issues will be assessed by comparing outcome measures between three groups: 1) therapists complete a self-paced virtual course + consultation, 2) therapists complete synchronous workshop + consultation, 3) control: therapists do not complete training.\n\nThe team of investigators developed Canada's largest psychotherapy practice-research network and has expertise in clinical trials, diversity, and education research of virtual training. State of the art training is often out of the reach of therapists who live outside of urban centres, and the effectiveness and acceptability of providing training virtually is not well-studied in mental health care. This study will improve psychotherapists' effectiveness at managing the therapeutic alliance and issues related to diversity, and will improve patient mental health outcomes thus promising to reduce the burden of mental illness.",[493],"Mental Disorders",[495,496,497,498,499,493,500],"Psychotherapists","Psychotherapy","Outcome Assessment, Healthcare","Cultural Diversity","Humans","Telemedicine","2025-07-18",{"date":503,"type":49},"2025-07-28",{"date":505,"type":49},"2023-08-02",{"date":507,"type":22},"2027-05-01",{"name":54,"class":55},{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":4,"eligibilityCriteria":515,"healthyVolunteers":64,"sex":91,"minAge":516,"maxAge":280,"enrollmentInfo":517,"targetDuration":4,"studyType":23,"phases":518,"briefSummary":519,"conditions":520,"keywords":521,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":135,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":526,"leadSponsor":528,"locationsCount":56},"100580872","influence-of-indoor-humidity-on-physiological-strain-in-older-adults-during-a-simulated-heat-wave-100580872","NCT06842953","Influence of Indoor Humidity on Physiological Strain in Older Adults During a Simulated Heat Wave","Is an Adjustment in the Recommended Indoor Temperature Upper Limit of 26°C Required During Higher Levels of Humidity?","Inclusion Criteria:\n\n* Non-smoking.\n* English or French speaking.\n* Ability to provide informed consent.\n* with or without a) chronic hypertension (elevated resting blood pressure; as defined by Heart and Stroke Canada and Hypertension Canada), b) type 2 diabetes as defined by Diabetes Canada, with at least 5 years having elapsed since time of diagnosis\n\nExclusion Criteria:\n\n* Episode(s) of severe hypoglycemia (requiring the assistance of another person) within the previous year, or inability to sense hypoglycemia (hypoglycemia unawareness).\n* Serious complications related to diabetes (gastroparesis, renal disease, uncontrolled hypertension, severe autonomic neuropathy).\n* Uncontrolled hypertension - BP \\>150 mmHg systolic or \\>95 mmHg diastolic in a sitting position.\n* Restrictions in physical activity due to disease (e.g. intermittent claudication, renal impairment, active proliferative retinopathy, unstable cardiac or pulmonary disease, disabling stroke, severe arthritis, etc.).\n* Use of or changes in medication judged by the patient or investigators to make participation in this study inadvisable.\n* Cardiac abnormalities identified during screening","60 Years",{"count":67,"type":22},[25],"Laboratory-based studies show that exposure to high humidity can worsen the effects of heat stress in young and older adults by impeding sweat evaporation - the main mechanism by which the human body cools itself. At high levels of humidity, the efficiency of sweating decreases causing a greater rise core temperature and burden on the cardiovascular system. In this context, increasing temperatures and humidity with climate change thus pose a potential compound risk for human health. While humidity's role in heat-health outcomes could substantially alter projections of health burdens from climate change, the impact of humidity on physiological strain in vulnerable people in relation to the indoor environment has yet to be evaluated. In a recent study delineating the physiological effects of the proposed 26°C indoor upper limit (PMID: 38329752), relative humidity was set to 45% in all conditions based on indoor humidity standards by the American Society of Heating and Air-Conditioning Engineers. However, it is unknown whether a refinement of the recommended indoor temperature limit of 26°C is required in situations where humidity cannot be maintained at this level.\n\nOn separate occasions, the investigators will assess the change in body temperature and cardiovascular strain in older adults (65-85 years) exposed for 10 hours at the recommended indoor temperature limit of 26°C and 45% relative humidity (equivalent humidex of 29 (considered comfortable)) (experimental condition A), to 26°C with a relative humidity of 15% (equivalent humidex of 23 (considered comfortable); humidex is used to measure the perceived temperature taking into account the humidity)) (experimental condition B), to 26°C with a relative humidity of 85% (equivalent humidex of 37 (considered somewhat uncomfortable)) (experimental condition C), and to 31°C and 45% relative humidity with an equivalent humidex of 37 (considered somewhat uncomfortable) that is similar to experimental condition C. With this experimental design, investigators will assess the effects of indoor humidity in driving human heat strain and identify whether refinements in the recommended 26°C indoor temperature limit may be required. Further, by evaluating changes in relation to ambient conditions with a similar humidex, the investigators can assess how individuals perceive and respond to both heat and humidity.",[29,34],[73,99,37,101,328,102,44,103],{"date":523,"type":49},"2025-06-15",{"date":525,"type":49},"2025-03-14",{"date":527,"type":22},"2026-09-01",{"name":54,"class":55},{"id":530,"slug":531,"hasResults":12,"nctId":532,"briefTitle":533,"officialTitle":534,"acronym":535,"eligibilityCriteria":536,"healthyVolunteers":12,"sex":91,"minAge":537,"maxAge":538,"enrollmentInfo":539,"targetDuration":4,"studyType":23,"phases":541,"briefSummary":542,"conditions":543,"keywords":546,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":551,"lastUpdatePostDateStruct":552,"startDateStruct":553,"completionDateStruct":555,"leadSponsor":557,"locationsCount":56},"100594677","social-prescribing-for-advancing-resilience-in-kids-a-pilot-study-of-social-prescribing-100594677","NCT07022561","Social Prescribing for Advancing Resilience in Kids: A Pilot Study of Social Prescribing","Social Prescribing for Advancing Resilience in Kids (SPARK): A Pilot Study of Social Prescribing for Children and Youth Mental Health in Canada","SPARK","Inclusion Criteria:\n\n* between 11-17 years of age\n* on the waitlist for mental health services\n* are not an immediate safety threat to themselves or others as assessed by the HEADS ED questionnaire\n\nExclusion Criteria:\n\n* Children \\\u003C 11 years old\n* Adolescents \\> 17 years old","11 Years","17 Years",{"count":540,"type":22},170,[25],"The goal of this clinical trial is to learn if the Social Prescription (SP) intervention helps improve mental health and wellbeing in youth. It will also assess the feasibility and acceptability of implementing SP in a community setting. The main questions it aims to answer are:\n\n* Is the SP intervention feasible and acceptable for youth, caregivers, and staff?\n* Does the SP intervention improve mental health outcomes, reduce stress, and increase wellbeing and social connectedness in youth?\n\nResearchers will compare the Social Prescription (SP) intervention to an education control group to evaluate its effectiveness in improving youth mental health and wellbeing.\n\nParticipants will:\n\n* Be randomized to receive either the SP intervention or be placed in an education control group\n* Complete wellbeing and mental health questionnaires at the beginning of the study and again after 12 weeks\n* Participate in qualitative interviews to share their experiences after participating in SP",[544,545],"Youth Mental Health and Wellbeing","Feasibility and Acceptability of the Social Prescribing Program",[547,548,549,550],"social prescribing","children and youth mental health","intervention","wellbeing","2025-06-06",{"date":523,"type":49},{"date":554,"type":22},"2025-07-01",{"date":556,"type":22},"2027-09-01",{"name":54,"class":55},{"id":559,"slug":560,"hasResults":12,"nctId":561,"briefTitle":562,"officialTitle":563,"acronym":4,"eligibilityCriteria":171,"healthyVolunteers":64,"sex":121,"minAge":18,"maxAge":172,"enrollmentInfo":564,"targetDuration":4,"studyType":23,"phases":565,"briefSummary":566,"conditions":567,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":571,"lastUpdatePostDateStruct":572,"startDateStruct":574,"completionDateStruct":576,"leadSponsor":578,"locationsCount":56},"100586196","hypoxia-appetite-and-energy-intake-in-young-female-adults-100586196","NCT06912230","Hypoxia, Appetite, and Energy Intake in Young Female Adults","Appetite and Energy Intake in Young Female Adults During and After Simulated High-Altitude",{"count":67,"type":22},[25],"The goal of this clinical trial is to investigate the effects of acute passive continuous hypoxemia (simulated high-altitude at rest) on appetite and energy intake in healthy young female adults. The main questions it aims to answer are:\n\n* Does six hours of simulated high-altitude (5000 meters) reduce scores of subjective appetite and energy intake?\n* Do changes in appetite and energy intake persist in the hours following the end of hypoxic exposure? Researchers will compare the effects of simulated high-altitude to a control normoxia (sea-level) condition to see if exposure to low oxygen levels independently affect appetite and energy intake.\n\nParticipants will:\n\n* Visit the laboratory for a preliminary screening session to assess eligibility.\n* Undergo two randomized, single-blind, experimental sessions consisting of six hours of passive exposure to normoxia or hypoxia in a climate-controlled chamber.\n* Consume foods provided from a curated list, served in ad libitum quantities, after leaving the laboratory to assess post-exposure energy intake.",[43,568,569,570],"Altitude","Appetite","Energy Intake","2025-03-28",{"date":573,"type":49},"2025-04-04",{"date":575,"type":49},"2024-11-13",{"date":577,"type":22},"2025-12",{"name":54,"class":55},{"id":580,"slug":581,"hasResults":12,"nctId":582,"briefTitle":583,"officialTitle":584,"acronym":4,"eligibilityCriteria":585,"healthyVolunteers":12,"sex":91,"minAge":516,"maxAge":4,"enrollmentInfo":586,"targetDuration":4,"studyType":23,"phases":587,"briefSummary":588,"conditions":589,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":593,"lastUpdatePostDateStruct":594,"startDateStruct":596,"completionDateStruct":598,"leadSponsor":600,"locationsCount":56},"100580888","robot-based-intervention-to-improve-physical-activity-in-older-adults-100580888","NCT06843161","Robot-based Intervention to Improve Physical Activity in Older Adults","Retraining Automatic Attitudes Towards Physical Activity and Sedentary Behaviour in Adults 60 Years of Age or Older","Inclusion Criteria:\n\n* 60 years of age or older\n* Able to walk\n* Able to communicate in English\n* Able to travel to the University of Ottawa Lees Campus\n\nExclusion Criteria:\n\n* Diagnosed neurological or psychiatric disorder\n* Impaired motor function of the upper limbs\n* Unable to understand task instructions",{"count":232,"type":22},[25],"Physical inactivity is considered a global pandemic negatively impacting the health of over 60% of older adults in America. Interventions aimed at improving physical activity in older adults focus on training reflective processes such as providing information on health benefits of physical activity. These interventions generally find that participants improved their intentions to be physically active rather than supporting actual change in behaviours to become physically active.\n\nThere is growing support for the idea that human behaviour is the result of a combination of quick automatic processes and slower reflective processes. Interventional studies have used cognitive bias modification tasks that target the quick automatic processes to retrain participant's bias. Such studies find that participant's bias towards diet, alcohol, and phobias can be altered using these cognitive bias modification tasks.\n\nIn this study, the investigators developed a new training task using a robotic device that aims to retrain automatic bias towards physical activity and sedentary behaviours. The robotic device allows greater immersive environments for participants to interact with and be more engaged with the cognitive bias modification task. This interventional study is testing whether this new robot-based training and the protocol for assessing physical activity is feasible for retraining older adults' bias towards physical activity and sedentary behaviour. Participants will be examined on their daily physical activity using an accelerometer, their physical ability using functional tests, and their perceptions on physical activity using questionnaires. To determine whether this protocol is feasible, the investigators will examine participant recruitment and retention rates.",[261,42,590,591,592],"Sedentary Behaviors","Bias, Implicit","Cognition","2025-02-27",{"date":595,"type":49},"2025-03-04",{"date":597,"type":22},"2025-03-01",{"date":599,"type":22},"2025-09-30",{"name":54,"class":55},{"id":602,"slug":603,"hasResults":12,"nctId":604,"briefTitle":605,"officialTitle":606,"acronym":4,"eligibilityCriteria":607,"healthyVolunteers":12,"sex":121,"minAge":18,"maxAge":4,"enrollmentInfo":608,"targetDuration":4,"studyType":23,"phases":610,"briefSummary":611,"conditions":612,"keywords":613,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":617,"lastUpdatePostDateStruct":618,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":56},"100498678","do-intravaginal-devices-reduce-urinary-incontinence-in-female-runners-100498678","NCT05773378","Do Intravaginal Devices Reduce Urinary Incontinence in Female Runners?","Do Intravaginal Devices Reduce or Eliminate Exercise Induced Urinary Incontinence in Female Runners?","Inclusion Criteria:\n\n* Females aged 18 years and over who run at least twice a week for a minimum of 10K\u002Fweek (minimum speed of 6 km\u002Fh to ensure high impact), who have done so for at least 6 months (to ensure adequate duration of exposure), and who commit to continue the same amount during the study period\n* Who regularly (≥ 1 per week) experience urine leakage while running.\n\nExclusion Criteria:\n\n* Any risk factors related to exercise;\n* Pain or musculoskeletal injury at the time of the screening;\n* History of urogenital surgery;\n* Symptoms of the female athlete triad;\n* Have a known neurologic disorder (e.g. stroke, multiple sclerosis);\n* Pregnancy or partum within the previous year;\n\nFor the in-lab assessment:\n\n* Ability to run with a moderately full bladder for 38 minutes on a treadmill\n* BMI ≥ 30\n* Pelvic organ prolapse ≥ 2",{"count":609,"type":22},90,[25],"More than one in five females experience the embarrassment and shame of urine leakage while exercising and this urinary incontinence (UI) is a substantial barrier to exercise. As many as one in three females with UI report that they limit their physical activity due to incontinence: 11.6% by not exercising at all, 11.3% by exercising less and 12.4% by changing the type of exercise they perform. It is imperative to look for alternatives to manage this condition, as it is a key reason why females abandon the very physical exercise that is necessary to maintain or improve their physical and mental health and their quality of life.\n\nWhile there is Grade A evidence for pelvic floor muscle training and some evidence for intravaginal pessaries to reduce symptoms of UI in general female populations, no study has evaluated the impact of conservative interventions specifically on UI experienced predominantly during running.",[391],[614,615,616,470,396],"exercise-induced urinary incontinence","running-induced urinary incontinence","intravaginal pessary","2024-12-11",{"date":619,"type":49},"2024-12-17",{"date":621,"type":49},"2023-04-14",{"date":623,"type":22},"2025-09-01",{"name":54,"class":55},{"id":626,"slug":627,"hasResults":12,"nctId":628,"briefTitle":629,"officialTitle":630,"acronym":4,"eligibilityCriteria":631,"healthyVolunteers":64,"sex":91,"minAge":18,"maxAge":4,"enrollmentInfo":632,"targetDuration":4,"studyType":23,"phases":633,"briefSummary":634,"conditions":635,"keywords":637,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":641,"lastUpdatePostDateStruct":642,"startDateStruct":644,"completionDateStruct":646,"leadSponsor":648,"locationsCount":56},"100564547","impacts-of-the-vega-family-violence-education-resources-for-psychology-trainees-100564547","NCT06630598","Impacts of the VEGA Family Violence Education Resources for Psychology Trainees","The Effects of the ©Violence, Evidence, Guidance, and Action (VEGA) Family Violence Education Resources on Canadian Clinical Psychology Students' Attitudes, Knowledge, and Behaviours","Inclusion Criteria:\n\n* Be a student in the Clinical Psychology graduate program of a Canadian university.\n* Be engaged in clinical work as part of program requirements\n* Speak and read English\n* Have internet access\n\nExclusion Criteria:\n\n-Currently participating in any other training relating to child maltreatment or intimate partner violence outside of mandatory or elective course material.",{"count":609,"type":22},[25],"The current research project aims to assess the effectiveness of the ©Violence, Evidence, Guidance, and Action (VEGA) Family Violence Education Resources (VEGA Project, 2019) in improving the knowledge, self-efficacy, and clinical responses of clinical psychology doctoral students to family violence in clinical settings. The VEGA on-line training is a collection of family violence online education resources designed to inform health and social service practitioners about family violence in a Canadian context, including definitions of family violence, mandatory reporting duties, effective responding to survivors, and more. Participants in this trial will be doctoral students recruited from accredited Clinical Psychology programs across Canada. Participants will be assigned to an intervention or wait-list control group, and the outcome measures consist of knowledge and attitudes about family violence, as well as measures of skills relevant to appropriately responding to survivors in clinical settings. Further, participants will be invited to complete a qualitative interview after the intervention to discuss overall impressions of the training and other ways the training changed their perspectives, if at all, on family violence.",[636],"Family Violence",[638,639,636,640],"Intimate Partner Violence","Child Maltreatment","Health Professions Education","2024-11-23",{"date":643,"type":49},"2024-11-26",{"date":645,"type":49},"2024-10-30",{"date":647,"type":22},"2025-03",{"name":54,"class":55},{"id":650,"slug":651,"hasResults":12,"nctId":652,"briefTitle":653,"officialTitle":654,"acronym":4,"eligibilityCriteria":655,"healthyVolunteers":12,"sex":121,"minAge":4,"maxAge":4,"enrollmentInfo":656,"targetDuration":4,"studyType":23,"phases":658,"briefSummary":659,"conditions":660,"keywords":4,"overallStatus":45,"whyStopped":4,"lastUpdateSubmitDate":663,"lastUpdatePostDateStruct":664,"startDateStruct":666,"completionDateStruct":668,"leadSponsor":670,"locationsCount":222},"100498327","optimizing-mental-health-for-infants-exposed-to-early-adversity-a-comparison-of-breaking-the-cycle-and-maxxine-wright-100498327","NCT05768815","Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparison of Breaking the Cycle and Maxxine Wright","Optimizing Mental Health for Infants Exposed to Early Adversity: A Comparative Effectiveness Trial of the Breaking the Cycle and Maxxine Wright Intervention Programs","Inclusion Criteria:\n\n* receiving services at either BTC or MW\n* having a child under the age of 6 years\n* being able to answer a questionnaire in English\n\nExclusion Criteria:\n\n\\-",{"count":657,"type":22},100,[25],"The goal of this clinical trial is to compare the effectiveness of the Breaking the Cycle (BTC) and Maxxine Wright (MW) programs in substance-involved mothers and their children. One key difference between the two programs is that the BTC program contains an infant mental health component while the MW program primarily focuses on the mothers. The main questions the trial aims to answer are:\n\n* Do children at BTC demonstrate enhanced infant mental health compared to children at MW up to 2 years post-intervention?\n* Do mother-child dyads at BTC experience more decreases in child adverse childhood experiences (ACE), maternal stress, and mental health symptoms and have better home environment scores, parenting attitudes, and mother-child relationship scores compared to mother-child dyads at MW?\n* Are enhanced infant mental health outcomes associated with children's lower psychosocial risk scores and mothers with lower ACE scores, lower depression and anxiety scores, and lower maternal stress?\n* Are the associations between treatment dose and infant mental health scores mediated by parenting attitudes and the mother-child relationship? Does child exposure to psychosocial risk moderate the association between treatment dose and child outcomes?\n* How do the mechanisms of change lead to the effectiveness of BTC? What are the potential lifetime health and non-health outcomes of at-risk children at BTC? What is the long-term social return on investment (SROI) of BTC?\n\nParticipants will complete several questionnaires at three timepoints while receiving services at either BTC or MW: during the intake phase, 12 months after their engagement in services and 24 months after their engagement in services.\n\nGiven that the two programs serve a similar demographic of women, researchers will compare the BTC group and the MW group to establish the comparative effectiveness and mechanisms of change of the infant mental health component of BTC.",[661,662],"Mother-Child Relations","Substance Use","2024-05-22",{"date":665,"type":49},"2024-05-23",{"date":667,"type":49},"2023-09-28",{"date":669,"type":22},"2026-12",{"name":54,"class":55},""]