[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Patras\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":241},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,54,84,117,136,164,198,219],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":35,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":42,"lastUpdatePostDateStruct":43,"startDateStruct":46,"completionDateStruct":48,"leadSponsor":50,"locationsCount":53},"100637471","balance-gait-and-motion-analysis-in-multiple-sclerosis-100637471",false,"NCT07630311","\"Balance, Gait, and Motion Analysis in Multiple Sclerosis\"","\"Functional Assessment of Balance and Gait and Correlation With Kinetic and Kinematic Parameters in Patients With Multiple Sclerosis: Cross-Sectional Study\"","MS-BALGAIT","Inclusion Criteria:\n\n* Adults (≥ 18 years) with confirmed diagnosis of Multiple Sclerosis\n* Expanded Disability Status Scale (EDSS) score \\\u003C6\n* Ability to ambulate independently without the use of assistive devices\n* Absence of significant orthopedic or neurological conditions affecting mobility\n* Ability to understand and follow verbal instructions.\n\nExclusion Criteria:\n\n* History of injury or surgical intervention to the lower limbs or spine within the past year\n* Any musculoskeletal, neurological, cardiovascular, or other medical condition, other than Multiple Sclerosis, that may significantly affect gait or balance or compromise participant safety during testing.\n* Severe balance impairment or high risk of falling that prevents safe participation in single-leg stance, gait analysis, or obstacle negotiation tasks.","ALL","18 Years",{"count":20,"type":21},40,"ESTIMATED","OBSERVATIONAL","The goal of this observational cross-sectional study is to investigate the relationship between functional measures of balance and gait and objective kinetic and kinematic parameters in people with Multiple Sclerosis (MS).\n\nThe main questions it aims to answer are:\n\ni) What is the relationship between kinetic and kinematic gait and balance parameters measured using the Vicon motion analysis system and performance on clinical functional assessments in people with Multiple Sclerosis?\n\nii) Which biomechanical parameters are most strongly associated with functional balance, gait, and physical performance outcomes?\n\nParticipants will attend a single laboratory-based assessment session. During this session, they will undergo biomechanical gait and balance analysis using the Vicon motion capture system, complete functional assessments of balance, gait, and physical performance, complete questionnaires assessing fear of falling and fatigue, and undergo assessment of lower-limb spasticity.",[25,26,27,28,29,30,31,32,33,34],"Multiple Sclerosis","Gait Disorders, Neurologic","Postural Balance","Motion Analysis","Biomechanics","Kinetics","Kinematics","Physiotherapy","Fatigue","Fall",[25,36,37,28,38,39,40,33,29],"Balance","Gait","Vicon System","Functional Assessments","Physical Performance","RECRUITING","2026-06-21",{"date":44,"type":45},"2026-06-24","ACTUAL",{"date":47,"type":45},"2025-09-01",{"date":49,"type":21},"2026-08-30",{"name":51,"class":52},"University of Patras","OTHER",2,{"id":55,"slug":56,"hasResults":11,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":60,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":18,"maxAge":64,"enrollmentInfo":65,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":67,"conditions":68,"keywords":70,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":78,"completionDateStruct":80,"leadSponsor":82,"locationsCount":83},"100622928","diaphragm-and-breathing-muscle-characteristics-in-women-with-and-without-diastasis-recti-abdominis-after-childbirth-100622928","NCT07389993","Diaphragm and Breathing Muscle Characteristics in Women With and Without Diastasis Recti Abdominis After Childbirth","Diaphragm Characteristics and Respiratory Muscle Function in Parous Women With and Without Diastasis Recti Abdominis","DRA-BREATH","Inclusion Criteria:\n\n* Female sex\n* Aged 18 to 50 years\n* Parous women (at least one previous childbirth)\n* At least 6 months postpartum at the time of assessment (and within 5 years postpartum)\n* Ability to understand and communicate in Greek\n* Willingness to participate and provide informed consent\n\nExclusion Criteria:\n\n* Current pregnancy\n* Delivery within the previous 6 months\n* History of severe chronic respiratory disease (e.g., chronic obstructive pulmonary disease, chronic bronchitis, pulmonary emphysema, pulmonary fibrosis)\n* Presence of connective tissue disorders\n* Presence of neurological disorders\n* Severe musculoskeletal conditions that could affect trunk or respiratory function or limit participation in testing procedures (severe low back pain, sciatica etc.)\n* Previous abdominal surgery, with the exception of cesarean section",true,"FEMALE","50 Years",{"count":66,"type":21},42,"Diastasis Recti Abdominis (DRA) is a common condition experienced postpartum, in which the abdominal muscles separate along the midline of the abdomen due to stretching and thinning of the linea alba. It's a common condition, affecting 66-100% of women post-birth and may be associated with changes in abdominal support, posture, breathing, and trunk function. Although DRA primarily affects the muscles of the abdominal wall, it is speculated that other muscles controlling and stabilizing the trunk, such as the pelvic floor muscles or the diaphragm, might be affected as well. Currently, several studies have investigated the possible negative effects of DRA on pelvic floor function. However, little is known about how it may be related to diaphragm function and accessory breathing muscles.\n\nThe purpose of this observational study is to compare diaphragm characteristics and function, and accessory breathing muscle strength in women who have given birth, with and without DRA.\n\nTo make this possible, adult parous women from the broader Achaia region are assessed and allocated into two predefined groups based on the presence or absence of DRA. Participants undergo a single assessment session including rehabilitative ultrasound imaging (RUSI) of the diaphragm and standardized tests of inspiratory muscle strength. Additional demographic and clinical information related to pregnancy and physical activity is also recorded. The main hypothesis of this study is that women with DRA demonstrate altered diaphragm function, as well as reduced inspiratory muscle strength, compared to women without DRA. The study aims to improve understanding of the possible relationship between DRA and breathing function after childbirth and to support future research and rehabilitation approaches for women with the condition.",[69],"Diastasis Recti Abdominis (DRA)",[71,72,73,74],"diastasis recti","diaphragm","RUSI","inspiratory muscle strength","2026-06-05",{"date":77,"type":45},"2026-06-09",{"date":79,"type":45},"2025-05-19",{"date":81,"type":21},"2026-07-10",{"name":51,"class":52},1,{"id":85,"slug":86,"hasResults":11,"nctId":87,"briefTitle":88,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":62,"sex":17,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":4,"studyType":96,"phases":97,"briefSummary":99,"conditions":100,"keywords":102,"overallStatus":108,"whyStopped":4,"lastUpdateSubmitDate":109,"lastUpdatePostDateStruct":110,"startDateStruct":112,"completionDateStruct":114,"leadSponsor":116,"locationsCount":53},"100629301","ai-informed-peer-mentoring-behavioral-intervention-for-anxiety-and-depression-primary-prevention-in-youth-100629301","NCT07472894","AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH","PEER MENTORING FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN ADOLESCENTS AND YOUNG ADULTS","PeerMentorAnxD","Inclusion Criteria: Healthy individuals aged 12-25 yrs old -\n\nExclusion Criteria: Chronic mental health conditions, severe cognitive or communication deficits\n\n\\-","12 Years","25 Years",{"count":95,"type":21},1680,"INTERVENTIONAL",[98],"NA","The goal of this clinical trial will be to evaluate the efficacy of an AI-informed peer-mentoring program to improve stress management and social skills and reduce the risk of depressive and anxiety symptoms in healthy adolescents (12-18 years old) and young adults (18-25 years old). The main question it aims to answer is whether the peer-mentoring behavioral intervention will achieve the desired behavioral changes and reduce the emergence of anxiety and depression symptoms. Researchers will compare the AI-informed peer-mentoring behavioral intervention program with a standard peer-mentoring program and a standard health educational program. Some study participants will be trained to be peer mentors and subsequently they will be paired with slightly younger mentees and they will attend shared activities for an academic year",[101],"Anxiety Depression",[103,104,105,106,107],"Anxiety","Depression","Primary prevention","Peer-mentoring","Behavioral Intervention","NOT_YET_RECRUITING","2026-04-09",{"date":111,"type":45},"2026-04-14",{"date":113,"type":21},"2027-09-01",{"date":115,"type":21},"2028-12-31",{"name":51,"class":52},{"id":118,"slug":119,"hasResults":11,"nctId":120,"briefTitle":121,"officialTitle":121,"acronym":4,"eligibilityCriteria":122,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":123,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":83},"100630734","double-immunosuppression-with-or-without-anti-fibrotic-in-scleroderma-ild-100630734","NCT07491523","Double Immunosuppression With or Without Anti-fibrotic in Scleroderma ILD","Inclusion Criteria:ild-ssc with double immunosuppression\n\n\\-\n\nExclusion Criteria:\n\n* ssc without ild",{"count":124,"type":21},35,"Patients with ssc-ild receiving double immunosuppression with or without anti fibrotic tratment",[127],"SSc-Systemic Sclerosis","2026-03-19",{"date":130,"type":45},"2026-03-24",{"date":132,"type":45},"2025-06-01",{"date":134,"type":21},"2027-03",{"name":51,"class":52},{"id":137,"slug":138,"hasResults":11,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":11,"sex":63,"minAge":18,"maxAge":64,"enrollmentInfo":144,"targetDuration":4,"studyType":96,"phases":146,"briefSummary":147,"conditions":148,"keywords":151,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":83},"100538109","rehabilitation-of-abdominal-diastasis-after-childbirth-trunk-and-inspiratory-muscle-training-100538109","NCT06286553","Rehabilitation of Abdominal Diastasis After Childbirth: Trunk and Inspiratory Muscle Training","Trunk Stabilization Exercise and Inspiratory Muscle Training Effects on Diastasis Recti Abdominis in Postpartum Women - A Randomized Controlled Trial","DR-TIME","Inclusion Criteria:\n\n* Females aged 18-50 years\n* Diagnosed with diastasis recti abdominis (DRA) with an inter-recti distance (IRD) greater than 2.8 cm\n* Beyond 6 months postpartum (preferably within the range of up to 5 years postpartum)\n\nExclusion Criteria:\n\n* Severe chronic respiratory disease (i.e. COPD, chronic bronchitis, pulmonary emphysema or fibrosis)\n* Connective tissue disorders\n* Neurological disorders\n* Severe musculoskeletal conditions hindering exercise participation (e.g., severe low back pain, sciatica, etc.)\n* Previous abdominal surgeries (excluding cesarean section)\n* Delivery within the last 6 months\n* BMI greater than 30 kg\u002Fm²",{"count":145,"type":21},48,[98],"Diastasis Recti Abdominis (DRA) is the separation of the rectus muscles caused by stretching and thinning of the linea alba during pregnancy and childbirth. It's a common condition, affecting 66-100% of women post-birth and can persist for many years, leading to abdominal protrusion, discomfort, and aesthetic concerns. It might also contribute to back pain, urinary issues, and reduced abdominal strength, impacting quality of life. Recent guidelines propose that conservative management, such as rehabilitation interventions, should be prioritized for DRA. However, there is a lack of consensus among researchers regarding the most effective exercise regimen, resulting in diverse rehabilitation programs. Recent evidence advocates not only for closing the gap but also for achieving optimal function. Current studies often neglect to address functional rehabilitation, underscoring the necessity for robust clinical trials, which is the primary focus of this study.\n\nAdditionally, although breathing exercises are commonly prescribed for DRA, the precise role of the diaphragm, the primary respiratory muscle, in rehabilitation hasn't been fully examined. The diaphragm forms the upper boundary of the abdominal cavity and plays a key role in the stability of the trunk, working together with the abdominal and pelvic floor muscles. A recent study found reduced diaphragm excursion in postpartum women with lumbopelvic pain during a low postural demanding task, while previous studies suggest that diaphragm training could alleviate such symptoms influencing factors such as diaphragm thickness and excursion, which may be linked to improved trunk stability. Hence, training the diaphragm and accessory inspiratory muscles through Inspiratory Muscle Training (IMT) could potentially play a crucial role in managing DRA.\n\nIn summary, the goal of this study is to develop and assess a comprehensive rehabilitation program aimed at effectively reducing DRA and addressing associated dysfunctions. The program will integrate evidence-based rehabilitation interventions, such as trunk stabilization exercises and IMT, targeting all related dysfunctions caused by DRA, and introducing a novel therapeutic protocol not previously implemented. The study will take the form of a prospective, randomized controlled trial (RCT).",[149,150],"Diastasis Recti And Weakness Of The Linea Alba","Diastasis, Muscle",[152,153,154,155],"Rehabilitation Research","Telerehabilitation","Exercise Therapy","Breathing Exercise","2026-01-16",{"date":158,"type":45},"2026-01-20",{"date":160,"type":45},"2024-03-11",{"date":162,"type":21},"2026-05-30",{"name":51,"class":52},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":170,"eligibilityCriteria":171,"healthyVolunteers":11,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":172,"targetDuration":4,"studyType":96,"phases":174,"briefSummary":175,"conditions":176,"keywords":180,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":190,"lastUpdatePostDateStruct":191,"startDateStruct":193,"completionDateStruct":195,"leadSponsor":197,"locationsCount":83},"100618651","impact-of-a-multicomponent-exercise-program-on-cognitive-and-functional-outcomes-in-patients-with-mild-cognitive-impairment-100618651","NCT07334392","Impact of a Multicomponent Exercise Program on Cognitive and Functional Outcomes in Patients With Mild Cognitive Impairment","Effectiveness of an Innovative Therapeutic Exercise Program on Physical and Cognitive Function in Mild Cognitive Impairment Due to Alzheimer's Disease","MExeProMCI","Inclusion Criteria:\n\n* individuals \\> 50 years old\n* people with confirmed cognitive impairment, as evidenced by values within normal limits on the Montreal Cognitive Assessment test (MOCA ) \\>20\n* stable medication in the last month\n* independent walking\n\nExclusion Criteria:\n\n* people with dementia\n* people suffering from chronic mental illness (e.g. schizophrenia, bipolar disorder)\n* people suffering from a neurological disorder or injuries (e.g. multiple sclerosis, Parkinson's, traumatic brain injury)\n* people with clinical depression (as determined by the Neuropsychiatric Inventory (NPI) assessment and medical diagnosis)\n* people who have had recent surgery\n* people with insufficient knowledge of the Greek language",{"count":173,"type":21},45,[98],"The goal of this randomised clinical trial is to investigate the effectiveness of an innovative therapeutic exercise program emphasizing in dual-task exercises in people with amnestic Mild Cognitive Impairment. The main questions it aims to answer are:\n\nDoes the innovative therapeutic exercise program improve gait and balance? Does the innovative therapeutic exercise program improve cognition?\n\nResearchers will compare the innovative therapeutic exercise program emphasizing in dual-task exercises to a therapeutic exercise program without emphasizing in dual-task exercises and to a control group (given instruction about the benefits of exercise).\n\nParticipants will:\n\n* Perform the exercise program twice a week for three months.\n* Will be assessed before and after the intervention.\n* Will record The Borg Scale of Perceived Exertion every second week to monitor and assess the progression of exercise intensity.",[177,178,36,179],"Mild Cognitive Impairment","Walking","Cognition",[181,182,183,184,185,186,187,188,189],"kinetic and kinematic","balance","global cognition","executive function","attention","mci","multicomponent program","exercise","dual tasking","2025-12-30",{"date":192,"type":45},"2026-01-12",{"date":194,"type":45},"2025-12-01",{"date":196,"type":21},"2026-11-30",{"name":51,"class":52},{"id":199,"slug":200,"hasResults":11,"nctId":201,"briefTitle":202,"officialTitle":203,"acronym":4,"eligibilityCriteria":204,"healthyVolunteers":11,"sex":63,"minAge":18,"maxAge":205,"enrollmentInfo":206,"targetDuration":4,"studyType":96,"phases":208,"briefSummary":209,"conditions":210,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":218,"locationsCount":83},"100581300","synchronous-and-asynchronous-telerehabilitation-for-women-with-urinary-incontinence-100581300","NCT06848517","Synchronous and Asynchronous Telerehabilitation for Women With Urinary Incontinence","The Effectiveness of a Blended Synchronous and Asynchronous Telerehabilitation Program for Greek Adult Women With Urinary Incontinence. A Randomized Controlled Trial","Inclusion Criteria:\n\n* Greek women,\n* 18-75 years old,\n* Diagnosis of Stress Urinary Incontinence (SUI) or Mixed UI (via Urodynamic examination).\n* Writing and reading of the Greek language\n* Having ease in using synchronous communication platforms (e.g., Zoom) and asynchronous educational videos via smart phones, tablets, computers etc\n* Able to voluntarily contract the PFM, during the initial clinical examination.\n\nExclusion Criteria:\n\n* 6 months after postpartum,\n* Systemic diseases\n* Malignancy,\n* Major gynecological surgery (i.e. total hysterectomy) over the last 10 years,\n* Neurological dysfunction,\n* Mental impairment","75 Years",{"count":207,"type":21},60,[98],"In the adult female Greek population,approximately 27% suffer from urinary incontinence (UI). Nowadays, the conservative, evidence-based and 'gold standard' therapy of UI involves pelvic floor muscles (PFM) training programs, which are effective when performed intensively (daily) and for at least three months' duration. Unfortunately, patients' adherence to PFM exercises programs is often compromised for various reasons (lack of patient interest, inability to exercise daily etc.). Therefore, the development of synchronous and asynchronous telerehabilitation programs has revolutionized UI treatment, because they offer an interactive environment which might increase patient motivation and improve patient's adherence to this demanding PFM exercise regime. Synchronous Telerehabilitation Programs (STP) have developed via communication platforms that allow users to connect with video, audio, phone, and chat applications (e.g. Zoom), where users can interact in real time with their therapist and follow their treatment through the PFM exercise program. Furthermore, Asynchronous Telerehabilitation Programs (ATP) have emerged via mobile applications, educational videos etc., where users can follow their treatment using the PFM exercise program at a more convenient time that fits into their personal schedule. Although some studies have examined either STP or ATP with or without face-to-face sessions, no study has investigated a blended approach of STP and ATP for the management of UI.\n\nGiven the above, the primary aim of this study is to evaluate the effectiveness of a blended STP and ATP, in comparison to face-to-face therapy sessions. A secondary objective is to investigate the level of patients' adherence, and the amount of supervision required, in a blended STP and ATP. Furthermore, the necessity of telerehabilitation programs (whether provided in a synchronous or asynchronous manner) in the field of pelvic floor dysfunctions specifically in UI, will be explored. Finally, the study will assess the usability of a telerehabilitation program (whether provided in a synchronous or asynchronous manner) in women with UI.",[211],"Urinary Incontinence,Stress","2025-02-21",{"date":214,"type":45},"2025-02-27",{"date":216,"type":45},"2025-02-15",{"date":162,"type":21},{"name":51,"class":52},{"id":220,"slug":221,"hasResults":11,"nctId":222,"briefTitle":223,"officialTitle":224,"acronym":225,"eligibilityCriteria":226,"healthyVolunteers":62,"sex":17,"minAge":64,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":96,"phases":229,"briefSummary":230,"conditions":231,"keywords":4,"overallStatus":41,"whyStopped":4,"lastUpdateSubmitDate":233,"lastUpdatePostDateStruct":234,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":53},"100556690","physical-activity-component-of-the-greek-interventional-geriatric-study-to-prevent-cognitive-impairment-and-disability-ginger-100556690","NCT06528379","Physical Activity Component of the Greek Interventional Geriatric Study to Prevent Cognitive Impairment and Disability (GINGER)","Physical Activity Component of the Greek Interventional Geriatric Study to Prevent Cognitive Impairment and Disability (GINGER): Study Protocol and Feasibility of the Assessment","GINGER","Inclusion Criteria include people with:\n\n* Subjective Cognitive Decline confirmed from the Subjctive Cognitive Decline Questionnaire (SCD - Q score \\>7)\n* Absence of objective cognitive imparement as confirmed from cognitive assessment tests (i.e. MoCA, Trail A \\& B, Stroop, RCFT, FAS. )\n\nExclusion Criteri include people with:\n\n* Mild Cognitive Impairement (MCI) or dementia\n* Chronic psychiatric or neurological disorders affecting cognition (i.e. bipolar disorder, schizophrenia, MS, TBI, Parkinson's disease etc.)\n* Unstable pathological diseases (i.e. uncontrolled hypothyrodism, athythmias, uncontrolled hypertension, high blood pressure at rest etc.)\n* Recent (\\\u003C6 month) surgery, which restrics active participation in exercise\u002Fphysical activity\n* inadequate knowledge of Greek",{"count":228,"type":21},200,[98],"The Greek Interventional Geriatric Study to Prevent Cognitive Impairment and Disability (GINGER) is a six-month multimodal, multicenter study aimed at people with Subjective Cognitive Impairement (SCI).\n\nOne of the GINGER's interventional components is the Physcial Activity (PA) component, coordinated by the University of Patras.\n\nThis PA component's scope is to determine whether an enhanced individualized physical exercise intervention programme can improve cognitive changes, physical function, quality of life and wellbeing in people with subjective cognitive decline.",[232],"People With Subjective Cognitive Impairement (SCI)","2024-07-31",{"date":235,"type":45},"2024-08-02",{"date":237,"type":45},"2024-05-20",{"date":239,"type":21},"2026-09-30",{"name":51,"class":52},""]