[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Pernambuco\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":77},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,48],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100617811","body-lateralization-and-its-effects-on-respiratory-drive-ventilation-and-pulmonary-aeration-in-critically-ill-patients-100617811",false,"NCT07323472","Body Lateralization and Its Effects on Respiratory Drive, Ventilation, and Pulmonary Aeration in Critically Ill Patients","Analysis of Respiratory Drive Activation, Ventilation, and Pulmonary Aeration Resulting From Body Lateralization in Critically Ill Patients Under Mechanical Ventilation","LATLUNG","Inclusion Criteria:\n\n* Patients of both sexes will be included;\n* Aged ≥ 18 years;\n* BMI 18-35 kg\u002Fm²;\n* Under invasive mechanical ventilation via orotracheal tube for ≥ 24 hours and expected to remain on mechanical ventilatory support for at least 48 hours;\n* Sedated (Richmond Agitation-Sedation Scale \\[RASS\\] -1 to -4);\n* Well adapted to protective ventilation strategies in VCV or PSV modes;\n* Presenting neural respiratory drive evidenced by a drop in Delta Pocc and\u002For the presence of assisted cycles;\n* Hemodynamically stable (mean arterial pressure between 60-120 mmHg, systolic arterial pressure between 90-180 mmHg, diastolic arterial pressure between 60-100 mmHg, and heart rate between 50-150 bpm) with or without vasoactive drugs at the time of data collection (\\> 0.1 to 0.3 mcg\u002Fkg\u002Fmin);\n* Respiratory stability, no use of accessory muscles and target SpO₂ achieved;\n* No indication for nebulization or heated humidification at the time of collection;\n* Positive tolerance test for lateral decubitus positioning;\n* Chest circumference of 78-87.9 cm (XS), 88-99.9 cm (S), or 100-111.9 cm (M).\n\nExclusion Criteria:\n\n* Patients presenting medical restrictions to body repositioning, or to the use of EIT or sEMG;\n* Those in therapeutic failure;\n* Individuals with spinal cord injury, brain injury, or stroke with a history of functional loss and respiratory impairment prior to hospitalization;\n* Neurological diseases affecting respiratory myoelectric conduction;\n* History of postural deformities, diaphragmatic abnormalities, or colostomy bag;\n* Unstable fracture (lower or upper limbs in proximal regions or thorax);\n* Pleural effusion requiring drainage;\n* Presence of drains in the thoracic and\u002For abdominal regions;\n* Unstable intracranial pressure;\n* Pregnant patients;\n* Immediate postoperative period of orthopedic surgeries;\n* Use of mucolytics;\n* Open ventriculostomy for drainage;\n* Uncontrolled agitation;\n* Pacemaker or implantable cardioverter-defibrillator;\n* Pneumothorax;\n* Use of neuromuscular blockers;\n* Active tuberculosis;\n* Traction devices;\n* Active bleeding;\n* Suspected or confirmed pulmonary embolism without prior treatment within 24 hours;\n* Presence of a large mass in the right and\u002For left hemithorax;\n* History of cardiopulmonary arrest within the past 24 hours under neuroprotection;\n* In the total weaning phase from IMV and\u002For tracheostomy and\u002For enteral feeding tube and\u002For scheduled CT scan within the next 6 hours;\n* Intolerance to the TLA test (SpO₂ drop \\\u003C92% or ≥20% from baseline, need for FiO₂ increase \\>50% or ≥20% from baseline, need for PEEP increase, or hemodynamic instability within the first 5 minutes of lateralization testing);\n* Those who refuse to provide consent, as determined by the legal representative.","ALL","18 Years",{"count":20,"type":21},30,"ESTIMATED","INTERVENTIONAL",[24],"NA","The goal of this quasi-experimental study is to investigate how different body positions, performed through Automatic Lateralization Therapy, affect respiratory drive, ventilation, and pulmonary aeration in critically ill adult patients under mechanical ventilation. The main questions this study aims to answer are:\n\n* Does Automatic Lateralization Therapy, modify respiratory drive, as measured by P0.1, estimated Pmus, and sEMG of the diaphragm and parasternal muscles?\n* Is there an association between respiratory drive, ventilation, and pulmonary aeration measured by Electrical Impedance Tomography (EIT) in different body positions promoted by Automatic Lateralization Therapy ?\n\nDoes combining Automatic Lateralization Therapy, with Flow Bias improve physiological and functional outcomes compared to Automatic Lateralization Therapy, without Flow Bias?\n\nParticipants will:\n\n* Be positioned in different lateralization strategies using Automatic Lateralization Therapy, while under mechanical ventilation;\n* Have respiratory parameters and ventilation images assessed by EIT and sEMG;\n\nParticipate only during their ICU stay, with no need for additional visits after discharge.",[27],"Intensive Care Units (ICUs)",[29,30,31,32,33,34],"Automatic lateralization therapy","Critical illness","Continuous lateral rotation","Electrical impedance tomography","Surface electromyography","Respiratory muscles","RECRUITING","2026-01-08",{"date":38,"type":39},"2026-01-09","ACTUAL",{"date":41,"type":39},"2026-01-01",{"date":43,"type":21},"2027-12-30",{"name":45,"class":46},"University of Pernambuco","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":59,"phases":4,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100538864","normative-values-for-peripheral-muscle-strength-in-critical-patients-and-healthy-individuals-100538864","NCT06296381","Normative Values for Peripheral Muscle Strength in Critical Patients and Healthy Individuals","Analysis of Peripheral Muscle Strength Measurement Methods in Healthy Individuals and Critical Patients: A Health Technology Assessment","HHD-ICU","Inclusion Criteria:\n\n* Healthy individuals of both sexes\n* Patients and volunteers aged between 18 and 90 years old (youth\u002Fadults\u002Felderly).\n* Patients admitted to the ICU.\n* No recent muscle injuries of both limbs for a past 6-months.\n\nExclusion Criteria:\n\nPatients and volunteers \\\u003C 20 years and \\> 90 years\n\nHealthy individuals\n\n* Unable to follow command completely\n* Severe osteoporosis or neuromuscular disease leading to decreased muscle strength\n* Presence of opened or infectious wound\n* Presence of pain in evaluating muscle groups\n\nPatients in ICU\n\n* Unable to follow command completely\n* Acute stroke\n* Hip fracture, unstable cervical spine or pathological fracture\n* Recent surgery involving the upper airways, chest, abdomen, or limbs\n* Presence of opened or infectious wound\n* Presence of pain in evaluating muscle groups","90 Years",{"count":58,"type":21},180,"OBSERVATIONAL","Muscle strength is an important indicator of overall health and is a factor that has been associated with increased mortality in critical patients. Its measurement must be reliable and reproducible to ensure a quality outcome for clinical applicability. Recently, the use of digital handheld dynamometers in intensive care has gained support; however, analysis becomes challenging due to the absence of standardized reference equations for the Brazilian population. The aim of this study is to develop reference equations for the Brazilian population and define specific cutoff points for men, women, healthy individuals, and critical patients.",[62,63],"Intensive Care Unit","Muscle Strength",[65,66,67],"Healthy Volunteers","Critically ill","Peripheral muscle","2025-09-13",{"date":70,"type":39},"2025-09-18",{"date":72,"type":39},"2024-03-01",{"date":74,"type":21},"2028-12-30",{"name":45,"class":46},4,""]