[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Pretoria\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":144},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,48,80,119],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100639540","the-effects-of-aerobic-exercise-and-mindful-breathing-on-individuals-with-major-depressive-disorder-in-saudi-arabia-100639540",false,"NCT07625163","The Effects of Aerobic Exercise and Mindful Breathing on Individuals With Major Depressive Disorder in Saudi Arabia","The Effects of Aerobic Exercise and Mindful Breathing on Symptom Severity and Quality of Life in Individuals With Major Depressive Disorder in Saudi Arabia: A Randomised Clinical Trial Protocol","MDD\u002FAE\u002FMB","Inclusion Criteria:\n\n1. Adults aged 18-60 years with a formal diagnosis of Major Depressive Disorder (MDD) based on DSM-5-TR or ICD-10 criteria.\n2. A baseline score of ≥ 17 on the Hamilton Depression Rating Scale (HAM-D) is required to ensure a moderate-to-severe symptom profile\n\nExclusion Criteria:\n\n1. Patients with high suicidal ideation\n2. Patients with a history of psychosis or bipolar disorder\n3. Patient with physical contraindications to exercise (e.g., unstable cardiovascular disease).\n4. Concurrent participation in other structured exercise\u002Fmindfulness trials.","ALL","18 Years","60 Years",{"count":21,"type":22},60,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this Randomized Clinical Trial is to evaluate the effectiveness of aerobic exercise (AE) and mindful breathing (MB) on depressive symptom severity and quality of life (QoL), in adults with MDD. The main question is: Does aerobic exercise and mindful breathing delivery reduce depressive symptom severity and improve quality of life more effectively than standard psychiatric care? The aims to answer are:\n\n1. To determine the effect of aerobic exercise interventions on depressive symptoms of individuals diagnosed with MDD.\n2. To determine the effect of aerobic exercise interventions on health-related quality of life among individuals diagnosed with MDD.\n3. To determine the effect of mindful breathing exercises on depressive symptoms among individuals diagnosed with MDD.\n4. To determine the effect of the mindful breathing exercise intervention on quality of life amongst individuals diagnosed with MDD.\n\nParticipants will be randomized into three groups:\n\n1. 45 minutes of moderate AE (60-75% HRR);\n2. 15 minutes of guided mindful breathing (6 breaths\u002Fminute);\n3. a waitlist control receiving standard care. \\*Interventions will occur three times a week for 16 weeks.",[28],"Major Depressive Disorder (MDD)",[30,31,32,33,34],"Major Depressive Disorder","Aerobic Exercise","Mindful Breathing","Quality of Life","Saudi Arabia","NOT_YET_RECRUITING","2026-06-01",{"date":38,"type":39},"2026-06-04","ACTUAL",{"date":41,"type":22},"2026-06-15",{"date":43,"type":22},"2026-11-14",{"name":45,"class":46},"University of Pretoria","OTHER",2,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":54,"targetDuration":4,"studyType":23,"phases":56,"briefSummary":57,"conditions":58,"keywords":60,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100591614","evaluating-the-clinical-effectiveness-of-a-community-based-hearing-aid-fitting-service-delivery-model-facilitated-by-community-healthcare-workers-chws-providing-smartphone-based-in-situ-and-pre-set-hearing-aid-fittings-in-low--and-middle-income-communities-lmics-100591614","NCT06982716","Evaluating the Clinical Effectiveness of a Community-based Hearing Aid Fitting Service Delivery Model Facilitated by Community Healthcare Workers (CHWs) Providing Smartphone-based In-situ and Pre-set Hearing Aid Fittings in Low- and Middle-income Communities (LMICs)","Inclusion Criteria:\n\n* 18 years and older\n* Confirmed mild to severe (20 to \\\u003C 80 dB PTA in both ears; (World Health Organization, 2021)) hearing loss (determined during baseline assessments)\n* Willing\u002Favailable to commit to at least 6- and 12-week follow-ups\n\nExclusion Criteria:\n\n* Younger than 18 years\n* Hearing loss too severe (≥80 dB HL PTA)\n* Normal hearing (\\\u003C20 dB HL PTA)\n* Middle ear pathology such as otitis media; active drainage from the ears.\n* Unwilling\u002Funavailable to commit to at least 6- and 12-week follow-ups.\n* Unilateral hearing loss",{"count":55,"type":22},90,[25],"The purpose of this study is to advance hearing care in low- and middle-income countries (LMICs) through the rigorous evaluation and optimization of innovative interventions and technologies. This study encompasses the following key aim:\n\nThis study aims to establish the effectiveness of community-based hearing aid fittings facilitated by community healthcare workers (CHWs) using mobile health (mHealth) technologies in low- and middle-income communities (LMICs). The primary goal is to determine the efficacy of CHW-facilitated smartphone-based in-situ hearing aid (HA) fittings (a proprietary fitting based on the NAL-NL2 algorithm) and pre-set HAs fittings compared to minimal amplification through a single-blind randomized controlled trial (RCT). By comparing self-reported benefits between the experimental and control groups, this aim seeks to demonstrate the superiority of the CHW-facilitated smartphone-based and pre-set hearing aid fittings compared to minimal amplification.",[59],"Hearing Loss",[61,62,63,64,65,66,67,68,69],"hearing loss","community-based","hearing aid","service delivery model","Community healthcare workers","in-situ","pre-set hearing aids","randomized controlled trial","low- and middle-income","RECRUITING","2025-08-28",{"date":73,"type":39},"2025-09-05",{"date":75,"type":39},"2025-05-21",{"date":77,"type":22},"2026-12-15",{"name":45,"class":46},3,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":88,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":94,"studyType":95,"phases":4,"briefSummary":96,"conditions":97,"keywords":101,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":110,"lastUpdatePostDateStruct":111,"startDateStruct":113,"completionDateStruct":115,"leadSponsor":117,"locationsCount":118},"100282399","screening-study-for-cervical-pre-cancer-and-cancer-prevention-in-south-african-women-100282399","NCT02956031","Screening Study for Cervical Pre-cancer and Cancer Prevention in South African Women.","Primary HPV Screening as an Indicator of Cervical Pre-invasive and Invasive Neoplasia in HIV-positive and -Negative Southern African Women","DiaVACCS","Inclusion Criteria:\n\n* Informed consent accepted and signed\n* Health seeking behaviour or request for a cervical cancer screening test\n* Willing and able to receive test result by automated text message or clinic visit\n\nExclusion Criteria:\n\n* Current pregnancy\n* Hysterectomy\n* Current or previous treatment for gynaecological cancer\n* Hesitant or unable to undergo screening and treatment if indicated",true,"FEMALE","25 Years","75 Years",{"count":93,"type":22},1500,"15 Years","OBSERVATIONAL","Nearly 8 000 new cervical cancer cases are diagnosed in South Africa per year; many are still undiagnosed and about 50% of diagnosed cases succumb per year. Although the current prevalence of pre-cancer cervical disease is largely unknown, data from local studies suggest regional differences and an increase in the prevalence of cytological abnormalities when compared with historical data. Low frequency in cytology screening is the primary factor attributable to development of invasive cervical cancer and almost one-third of all cervical cancer patients had previous negative cytology. Due to the low sensitivity of cytology it can be assumed that the true prevalence of pre-cancer disease is underestimated by all available data. One round of optimal cervical cytology will detect around 50% of existing pre-cancer cervical disease as identified and proven using colposcopy and directed biopsy. It is now widely accepted that primary screening with a human papilloma virus (HPV) test can improve the sensitivity of screening and that even a single round of HPV screening can rapidly reduce the incidence of invasive cervical cancer and related mortality within a few years.\n\nSouth Africa has a high prevalence of HIV infection and a delay in or failure to initiate antiretroviral therapy (ART). These facts, together with the largely unscreened status of the female population and the high incidence of cervical cancer all suggest that HPV infection and precursors to cervical cancer are both unusually common among South African women. Accurate current knowledge of the performance of newer generation HPV based screening tests in HIV-infected and general female population are essential for cost-analysis and planning for national prevention and screening programs. This study will aim to demonstrate the feasibility and efficacy of new generation HPV deoxyribonucleic acid (DNA) based screening assays in a South African setting.\n\nThe investigators hypothesize that HPV testing followed by normal and special cytology tests will be a successful screening model for a South African population.",[98,99,100],"Cervical Cancer","High Grade Sil","CIN2",[102,103,104,105,106,107,108,109],"cancer prevention","cervical screening","cervical cancer","cervical disease","cervical neoplasm","HPV testing","immunocytochemistry","triage techniques","2025-07-02",{"date":112,"type":39},"2025-07-08",{"date":114,"type":39},"2016-12",{"date":116,"type":22},"2038-12",{"name":45,"class":46},1,{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":123,"acronym":4,"eligibilityCriteria":124,"healthyVolunteers":11,"sex":89,"minAge":18,"maxAge":4,"enrollmentInfo":125,"targetDuration":4,"studyType":95,"phases":4,"briefSummary":127,"conditions":128,"keywords":130,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":136,"lastUpdatePostDateStruct":137,"startDateStruct":139,"completionDateStruct":141,"leadSponsor":143,"locationsCount":118},"100553567","the-validity-of-the-use-of-imaging-in-cervical-cancer-staging-100553567","NCT06487767","The Validity of the Use of Imaging in Cervical Cancer Staging","Inclusion Criteria:\n\n\\- Women diagnosed with cervical cancer Able and willing to provide informed consent\n\nExclusion Criteria:\n\nPreviously treated for cervical cancer Unable to provide informed consent Patients with contra-indications to undergo surgical treatment\n\n\\-",{"count":126,"type":22},100,"The study wil aim to investigate the accuracy of imaging in the staging of women diagnosed with cervical cancer",[129],"Cervical Cancer Stage, Imaging Modalities",[131,132,133,134,135],"Cervical cancer","Ultrasound","MRI","CT Scan","PET-CT scan","2024-06-27",{"date":138,"type":39},"2024-07-05",{"date":140,"type":22},"2024-07-01",{"date":142,"type":22},"2026-12-31",{"name":45,"class":46},""]