[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Primorska\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":105},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,47,80],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":30,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":5},"100625471","the-impact-of-continuous-glucose-monitoring-on-glucose-variability-and-weight-loss-in-individuals-with-prediabetes-and-obesity-100625471",false,"NCT07423065","The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity","The Impact of Continuous Glucose Monitoring on Behavioral Change, Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity - a Randomized Crossover Study","CGM","Inclusion Criteria:\n\n* Adults aged 18-70 years.\n* BMI ≥ 27 kg\u002Fm² (overweight or obese).\n* Prediabetes, confirmed by:\n\nImpaired fasting glucose (IFG: 5.6-6.9 mmol\u002FL), and\u002For Impaired glucose tolerance (IGT: 2-hour OGTT glucose 7.8-11.0 mmol\u002FL).\n\n* Stable body weight (±3 kg) in the last 3 months.\n* No current use of antidiabetic or weight-loss medications.\n* Willingness and ability to wear a CGM device as instructed.\n* Capacity to provide written informed consent.\n* Recruitment from the Diabetes Outpatient Clinic, Community Health Center Koper (identified and invited from the clinic's database).\n\nExclusion Criteria:\n\n* Diagnosis of type 1 or type 2 diabetes mellitus (fasting glucose ≥ 7.0 mmol\u002FL or HbA1c ≥ 6.5%).\n* Current or recent (within 3 months) use of:\n* Any antidiabetic medication (insulin, metformin, GLP-1RA, SGLT2i, etc.), or anti-obesity pharmacotherapy.\n* Pregnancy, breastfeeding, or planned pregnancy during the study period.\n* Severe chronic disease that could influence glucose metabolism or study participation (e.g., chronic liver disease, renal failure, active malignancy).\n* Endocrine disorders affecting metabolism (e.g., untreated thyroid disease, Cushing's syndrome).\n* Severe psychiatric illness or cognitive impairment limiting adherence or comprehension.\n* Use of medications known to affect glucose metabolism (e.g., corticosteroids, atypical antipsychotics).\n* Implanted electronic medical devices (e.g., pacemaker, defibrillator) that may interfere with CGM function.\n* Known allergy or skin reaction to CGM adhesives or device materials.\n* Participation in another interventional study within the previous 3 months.","ALL","18 Years","70 Years",{"count":21,"type":22},34,"ESTIMATED","INTERVENTIONAL",[25],"NA","This randomized, crossover interventional study evaluates the effects of real-time (open) versus blinded continuous glucose monitoring (CGM) on glycemic variability, lifestyle behaviors, and metabolic outcomes in adults with prediabetes and overweight or obesity (BMI ≥ 27 kg\u002Fm²). Thirty participants will undergo both open and blinded CGM phases, separated by a washout period. The study aims to assess whether access to real-time glucose data promotes behavioral change and improves metabolic health compared with blinded CGM use.",[28,29],"Pre Diabetic","Obesity & Overweight",[31,32,33,34],"continuous glucose monitoring","obesity","prediabetes","behavior","RECRUITING","2026-04-27",{"date":38,"type":39},"2026-04-28","ACTUAL",{"date":41,"type":22},"2026-09-01",{"date":43,"type":22},"2027-09-01",{"name":45,"class":46},"University of Primorska","OTHER",{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":17,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":79},"100613045","early-phase-1-crocus-sativus-tepals-water-extract-in-obesity-and-prediabetes-100613045","NCT07261475","Crocus Sativus Tepals Water Extract in Obesity and Prediabetes","Acute Effects of Water Extract of Crocus Sativus Tepals on Metabolic Health Parameters in Patients With Obesity and Prediabetes","ZAFRAN","Inclusion Criteria:\n\n* Obesity type I (ITM \\> 30 kg\u002Fm2) and\u002For\n* Prediabetes (fasting glucose levels 6,1 - 6,9 mmol\u002FL)\n\nExclusion Criteria:\n\n* Gastrointestinal diseases\n* Diabetes mellitus of any type\n* Pregnant or lactating, without contraception\n* Serious clinical conditions such as cancer, severe infections, severe psychiatric disorders, autoimmune diseases, inflammatory diseases\n* Participation in another clinical trial 3 months prior to the study\n* ITM greater than 35 kg\u002Fm2\n* Celiac disease of gluten intolerance\n* electronic implant","40 Years","65 Years",{"count":58,"type":22},20,[60],"EARLY_PHASE1","The goal of this clinical trial is to determine the acute effects of ingestion of a cold aqueous extract of Crocus sativus tepals on postprandial glycemia and other indicators of metabolic health in patients with obesity and\u002For prediabetes. The main questions it aims to answer are:\n\n* Does the ingestion of Crocus sativus tepals cold aqueous extract prior to a meal improve the glycemic response to a standard meal?\n* How does the ingestion of Crocus sativus tepals aqueous extract prior to a meal impact insulin levels and other markers of metabolic health?\n* Does the ingestion of Crocus sativus tepals cold aqueous extract prior to a meal increase the resting energy expanditure?\n\nResearchers will compare Crocus sativus tepals cold aqueous extract to cold water.\n\nThe participants will visit the Faculty twice - on one visit they will ingest Crocus sativus tepals cold aqueous extract and on the other cold water (in random order) 5 minutes prior to a standard meal of 100 g of white bread.\n\nOn each visit, anthropometric measurements will be performed upon arrival. Blood samples will be collected 3 times, preceeded by resting metabolic rate and blood pressure measurements: at baseline in fasted conditions, and 60 minutes and 120 minutes after consuming the bread.\n\nThere will be an at least 7 days wash-out period between the two visits.",[63,29],"Prediabetes",[65,66,67,68,69,70],"Crocus sativus tepals","Glycaemia","Oral glucose tolerance test","resting metabolism","blood pressure","insulin","2026-02-03",{"date":73,"type":39},"2026-02-04",{"date":75,"type":22},"2026-02-06",{"date":77,"type":22},"2026-12",{"name":45,"class":46},1,{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":4,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":89,"maxAge":90,"enrollmentInfo":91,"targetDuration":4,"studyType":23,"phases":93,"briefSummary":94,"conditions":95,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":79},"100601916","unloading-maneuvers-during-spinal-flexion-exposure-100601916","NCT07116720","Unloading Maneuvers During Spinal Flexion Exposure","The Effect of Unloading Maneuvers During Spinal Flexion Exposure","Inclusion Criteria:\n\n* Occupational workers with a predominantly non static job (e.g. combination of sitting and standing)\n\nExclusion Criteria:\n\n* History of chronic low back pain\n* Episode of acute low back pain\n* Hip injury in the past six months\n* Previous spine, pelvis or hip surgery\n* Hypermobility, diagnosed with the Beighton score\n* High intensity resistance training (\\> 75 % of 1 repetition maximum) more than two times a week\n* Sporting or recreational activities, that include repetitive spinal flexion or maintenance of a flexed posture (for example cycling or rowing).",true,"MALE","30 Years","55 Years",{"count":92,"type":22},30,[25],"An experimental study, which will aim to investigate the acute effects of unloading maneuvers during an intermittent spinal flexion protocol on changes in trunk mechanical and neuromuscular properties.",[96],"Occupational Exposure","2025-08-06",{"date":99,"type":39},"2025-08-12",{"date":101,"type":22},"2025-08-25",{"date":103,"type":22},"2025-10-15",{"name":45,"class":46},""]