[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Reading\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":496},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,17,0,[8,48,80,114,152,177,199,227,255,279,304,337,362,389,412,443,469],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":31,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100643989","probiotics-for-depressive-symptomatology-and-neural-activity-100643989",false,"NCT07667530","Probiotics for Depressive Symptomatology and Neural Activity.","The Acute and Chronic Effects of Ecologic® Barrier on Depressive Symptoms and Neural Activation.","PRODAN","Inclusion Criteria:\n\n* Mild to moderate depression symptoms (BDI-II 12-28)\n* Males and females\n* Age range will be 25-40 years\n* Right-handed participants only (required for EEG)\n\nExclusion Criteria:\n\n* Taking antidepressants (up to 2 months prior to inclusion)\n* Undergoing psychological treatment in the form of counselling, therapy or similar (up to 1 month prior to inclusion)\n* Any diagnosed chronic medical condition (e.g. diabetes) or psychiatric illness.\n* Use of antibiotics or laxatives (up to 3 months prior to inclusion)\n* Use of probiotics and\u002For prebiotics (up to 1 month prior to inclusion)\n* Enrolled in any other clinical trial (up to 1 month prior to inclusion)\n* Following restrictive and\u002For unbalanced diets\n* Smoking\n* Continuous use of a weight-loss medication for more than one month prior to screening\n* Significant gastrointestinal conditions affecting absorption, including but not limited to: inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end-stage renal disease; active cancer or cancer treatment within the past three years","ALL","25 Years","40 Years",{"count":21,"type":22},76,"ESTIMATED","INTERVENTIONAL",[25],"NA","This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.",[28,29,30],"Mild-to-moderate Depression","Neural Activity","Executive Function (Cognition)",[28,32,33,34],"Probiotic Supplementation","Neural Activation","Executive Function","NOT_YET_RECRUITING","2026-06-19",{"date":38,"type":39},"2026-06-25","ACTUAL",{"date":41,"type":22},"2026-07-01",{"date":43,"type":22},"2027-03-01",{"name":45,"class":46},"University of Reading","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":60,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":47},"100629039","the-effects-of-high-dose-vitamin-b6-on-depression-and-anxiety-symptoms-100629039","NCT07469462","The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms","An EEG Study to Investigate the Effect of High-dose Vitamin B6 Supplementation on Neural Activity in Relation to Depression and Anxiety Symptoms.","Inclusion Criteria:\n\n* Over 18 years of age and under 41\n* Mild to moderate anxiety and\u002For depression\n* Normal or corrected to normal vision\n\nExclusion Criteria:\n\n* not taking daily dietary supplement containing \\>2 mg Vitamin B6\n* not taking medication that is a GABA agaonist (our team will check this with you)\n* not be pregnant\n* no medical history of epilepsy\n* no medical history of peripheral neuropathy\n* not taking the antibiotic Seromycin (prescribed for tuberclosis or urinary tract infection)\n* no history of brain injury or recent concussion",true,"18 Years","41 Years",{"count":59,"type":22},44,[25],"This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation\u002Finhibition balance towards inhibition.",[63,64,65],"Neural Inhibition","Anxiety","Depression",[67,68,69,70,65,64],"Vitamin B6","Excitation-Inhibition Balance","GABA","Electroencephalograpgy","RECRUITING","2026-04-27",{"date":74,"type":39},"2026-04-28",{"date":76,"type":22},"2026-05-01",{"date":78,"type":22},"2026-11",{"name":45,"class":46},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":87,"healthyVolunteers":55,"sex":17,"minAge":88,"maxAge":89,"enrollmentInfo":90,"targetDuration":4,"studyType":23,"phases":92,"briefSummary":93,"conditions":94,"keywords":99,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":108,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":47},"100623790","gutlink4kids-intervention-100623790","NCT07401212","GUTLINK4KIDS Intervention","The Impact of Chronic Consumption of Prebiotics on Cognitive and Affective Outcomes, Gut Microbiome Diversity and Composition in 3-5 Year Olds: a Double-blind Placebo-controlled, Parallel-groups Randomised Controlled Trial","GUTLINK4KIDS","Inclusion Criteria:\n\n* Parents (18 years and over) of generally healthy children aged 3-5-years-old (36-71 months) with lower dietary fibre intake than the recommended daily amount (10.4g\u002Fday in 18-47-month-olds and less than 12.6g\u002Fday in 48-60-month-olds).\n\nExclusion Criteria:\n\n* Children with a significant acute or chronic co-existing illness (including inflammatory bowel disease, functional gastrointestinal disorders, coeliac disease etc, neurodevelopmental, immunological, psychiatric, or metabolic disorders.\n* Children who have taken any pre\u002Fprobiotic supplements or antibiotic treatment within the 4 weeks prior to enrolment.\n* Children with food allergies and intolerances","3 Years","5 Years",{"count":91,"type":22},106,[25],"This study aims to investigate the chronic effects of prebiotic consumption on cognitive, behavioural and gut microbiome outcomes in children aged 3-5 years.",[95,96,97,98],"Temperament","Sleep","Cognition","Emotion Regulation",[100,101,102,103,104,105,106,107],"prebiotics","emotion regulation","gut microbiome diversity","children","relative abundance","sleep","internalising symptoms","externalising symptoms",{"date":74,"type":39},{"date":110,"type":39},"2026-03-02",{"date":112,"type":22},"2027-02-01",{"name":45,"class":46},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":120,"eligibilityCriteria":121,"healthyVolunteers":55,"sex":17,"minAge":122,"maxAge":123,"enrollmentInfo":124,"targetDuration":4,"studyType":23,"phases":126,"briefSummary":127,"conditions":128,"keywords":133,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":144,"lastUpdatePostDateStruct":145,"startDateStruct":147,"completionDateStruct":149,"leadSponsor":151,"locationsCount":47},"100635242","etascan-project-etas-project-2-100635242","NCT07550140","ETASCAN Project: ETAS Project 2","The Impact of Chronic Consumption of ETAS® for 12 Weeks on Cognitive, Affective, and Neural Outcomes: A Randomised Parallel Group Placebo-controlled Study","ETASCAN","Inclusion Criteria:\n\n* Aging between 60-80 years old\n* Having normal vision and hearing\n* Having a body mass index between 18.5 and 30\n* Having mild to moderate subjective cognitive complaints\n\nExclusion Criteria:\n\n* Smoking\n* Having food allergies\n* Following restrictive and\u002For unbalanced diets (Appendix 6: Are you vegetarian or vegan? Yes \u002F No; Are you currently on a weight-reducing or other special diet? Yes\u002FNo If 'Yes', please give details.)\n* Being diagnosed with any psychiatric or neurologic conditions (e.g. schizophrenia, depression, dementia) including eating disorders\n* Being diagnosed with any cardiometabolic diseases (including type II diabetes and cardiovascular disease), or hypertension or thrombosis related disorders or suffer from thyroid disease\n* Currently taking anticoagulants, antiplatelet medication, antidepressants, proton-pump inhibitors\n* Currently consuming prebiotic or probiotic supplements\n* Continuous antibiotic use for \\> 3 days within 1 month prior to enrolment\n* Continuous use of weight-loss drug for \\> 1 month before screening\n* Having a significant gastrointestinal (GI) condition affecting absorption including (but not limited to) inflammatory bowel disease; total colectomy or bariatric surgery; irritable bowel disease; end stage renal disease; active cancer, or treatment for any cancer, in last 3 years\n* History of claustrophobia\n* Fitted with a pacemaker or artificial heart valve\n* Have active implants, such as cochlear, ocular, or penile implant\n* Experience of metal fragments e.g. shrapnel in your eyes or any other part of your body\n* Drug infusion pump installed\n* Have any surgically implanted metal in any part of your body, other than dental fillings and crowns (e.g. joint replacement or bone re-construction)\n* Have had any surgery that might have involved metal implants\n* Current or historical experience of epilepsy\n* Have stimulators for nerves, brain or bone installed\n* Have an intrauterine contraceptive device installed (IUD)\n* Wear transdermal patches containing metal\n* Wear a filling, crown, dental post (entirely within the tooth) associated with root canal treatment, retainer, bridge or braces\n* For scanning, would need to remove coloured contact lenses, nail polish and makeup.\n* Hearing aid wearer\n* Body piercings that you cannot or will not remove for the scanning session\n* Have tattoos or permanent makeup","60 Years","80 Years",{"count":125,"type":22},60,[25],"This study aims to investigate the chronic effects of ETAS® on cognitive, affective and neural outcomes in healthy adults aged 60-80 years with mild to moderate subjective cognitive complaints.",[97,129,96,130,131,132],"Affect (Mental Function)","MRI","fMRI","Magnetic Resonance Spectroscopy",[134,135,136,137,138,139,140,141,142,105,143],"grey matter","brain structure","brain function","neurochemistry","executive function","language","ETAS®","depression","anxiety","gut microbiome","2026-04-17",{"date":146,"type":39},"2026-04-24",{"date":148,"type":22},"2026-05-05",{"date":150,"type":22},"2027-12-31",{"name":45,"class":46},{"id":153,"slug":154,"hasResults":11,"nctId":155,"briefTitle":156,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":159,"enrollmentInfo":160,"targetDuration":4,"studyType":23,"phases":162,"briefSummary":163,"conditions":164,"keywords":166,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":175,"leadSponsor":176,"locationsCount":47},"100631341","the-effects-of-the-bile-acid-supplement-7-keto-lithocholic-acid-on-human-gut-microbiota-and-risk-factors-for-disease-100631341","NCT07499414","The Effects of the Bile Acid Supplement, 7-keto Lithocholic Acid, on Human Gut Microbiota and Risk Factors for Disease.","BioMet-7","Inclusion Criteria:\n\n* Volunteer is healthy (good physical and mental condition, disease-free, with haemoglobin levels between 138 - 172 g\u002FL for male and between 121 and 151 g\u002FL for female) at the time of pre-examination\n* Volunteer is aged ≥ 18 to ≤ 65 years for the duration of the study\n* Volunteer is able and willing to comply with the study instructions\n* Volunteer is suitable for participation in the study according to the investigator\u002Fstudy personnel\n* Volunteer is able to give informed consent\n* Volunteer must be following a non-restrictive diet according to the investigator\u002Fstudy personnel (no vegan, keto or fasting diets)\n* Volunteer has not consumed pro- or prebiotic supplements or food products for a minimum of 4 weeks prior to starting the intervention.\n* Volunteer has no gastrointestinal disorders\n\nExclusion Criteria:\n\n* No command of any local language\n* Gastrointestinal disorders including IBS, IBD or other conditions that might affect the gut environment\n* Food allergies or intolerances\n* Using drugs (e.g. antibiotics) influencing gastrointestinal function (12 weeks before intervention)\n* Use of laxatives\n* Clinically significant diabetes (plasma glucose test, fasting blood glucose \\> 6.5 mmol\u002Fl (120 mg\u002FdL)\n* Volunteers currently involved or will be involved in another clinical\u002F food study for the duration of this study\n* History of drug (pharmaceutical or recreational) or alcohol abuse.\n* If participants are pregnant or are lactating\n* Regular intake of probiotic or prebiotic supplements\n* Smoker\n* Those who follow extreme diets (Keto-diet, Atkins diet, vegan)\n* Those taking prescribed medication for existing health condition(s)\n* Those with a pacemaker","65 Years",{"count":161,"type":22},40,[25],"In humans and most mammals, bile acids play a role in the metabolism of glucose and the transport and absorption of lipids (such as cholesterol and triglycerides), vitamins, and nutrients by allowing for emulsification (mixing) and absorption of fatty molecules that are consumed. More recently, bile acids have been discovered to influence the composition and quantity of the microorganisms in the gut microbiome. Bile acids also act as signalling molecules (like hormones) in the body, regulating important metabolic pathways and digestion.\n\nWhile the majority of bile acids are recycled back to the liver, a small proportion of these bile acids enter the colon and interact with the gut microbiota. Primary bile acids, synthesized in the liver, are essential for the absorption of fat- and fat-soluble vitamins, as part of the digestive process. These primary bile acids are converted to secondary bile acids by gut bacteria, which have been shown to have benefits to health. This provides the rationale for exploring the use of a bile acid, in this case 7-keto lithocholic acid (7-KLCA), as a beneficial modulator of the gut microbiome, to help regulate metabolic and potentially other disease pathways.",[165],"Healthy",[143,167,168,169],"metabolic health","7-KLCA","bile acid","2026-03-23",{"date":172,"type":39},"2026-03-30",{"date":174,"type":22},"2026-04-06",{"date":150,"type":22},{"name":45,"class":46},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":182,"acronym":4,"eligibilityCriteria":183,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":122,"enrollmentInfo":184,"targetDuration":4,"studyType":23,"phases":185,"briefSummary":186,"conditions":187,"keywords":189,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":47},"100534105","testing-the-efficacy-of-100mg-vitamin-b6-daily-for-sensory-reactivity-in-autism-100534105","NCT06234501","Testing the Efficacy of 100mg Vitamin-B6 Daily for Sensory Reactivity in Autism","Testing the Potential of High-dose Vitamin B6 Supplements for Sensory Reactivity in Autism","Inclusion Criteria:\n\n* Between the ages of 18 to 60\n* With a diagnosis of autism\n\nExclusion Criteria:\n\n* Taking any supplement that contains more than 2mg of Vitamin B6 or taking GABA agonist drugs\n* Have a medical history of peripheral neuropathy\n* lactose intolerance (placebo tablet is lactose based)",{"count":161,"type":22},[25],"This clinical trial aims to explore the effect of Vitamin B6 supplementation on anxiety sensory hyperreactivity in autistic adults. Researchers will compare a placebo group to high-dose Vitamin-B6 to see if vitamin B6 reduce anxiety and sensory reactivity differences in autism.",[188],"Autism",[67,190,69,68,188],"Sensory Hyperreactivity","2026-03-09",{"date":193,"type":39},"2026-03-11",{"date":195,"type":39},"2024-11-08",{"date":197,"type":22},"2026-07",{"name":45,"class":46},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":207,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":210,"conditions":211,"keywords":214,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":225,"locationsCount":226},"100583688","identifying-the-best-tools-for-recording-diet-in-free-living-uk-adults-sodiat-2-study-100583688","NCT06879574","Identifying the Best Tools for Recording Diet in Free-living UK Adults (SODIAT-2 Study)","Investigating a Data-driven Standardized and Objective Dietary Intake Assessment Tool in Free-living Individuals - SODIAT-2 Study","SODIAT-2","Inclusion Criteria:\n\n* 18 years and older\n* Lives in Great Britain (England, Schotland and Walse)\n* Able to read\u002Funderstand instructions written in English and are fluent in English\n\nExclusion Criteria:\n\n* Diagnosed or self-report as being underweight (have a body mass index (BMI) of less than 18.5 kg\u002Fm2)\n* Are unwilling\u002Funable to collect urine and blood samples, use the wearable camera as instructed and\u002For spend 20-30 min online recording what they've recently had to eat\u002Fdrink on multiple occasions\n* Are unwilling\u002Funable to have a video call with a researcher with cameras turned on\n* Are unwilling\u002Funable to post samples on specific days and receive\u002Fsend a larger parcel at the start\u002Fend of the study (note: all return packaging and postage will be provided by us and will include a courier delivery and collection)\n* Are unwilling\u002Funable to receive a single grocery delivery from Sainsbury's or Tesco online supermarkets (delivery to be arranged by us), includes living in a postcode area that cannot receive grocery deliveries from Tesco or Sainsburys as well as not having space to refrigerate and freeze items.\n* Are unwilling\u002Funable to eat\u002Fdrink any items on the calibration menu, e.g., food allergies\u002Fintolerances, dislike of food items, unable eat (e.g. vegan or have to avoid for a medical condition) or cannot eat 3 meals plus snacks daily (note: vegetarians can take part)\n* Are unwilling\u002Funable to avoid taking dietary and herbal supplements for at least 1 week before and during the 5-week study (e.g. fish oils, vitamins, iron, protein shakes, nutrient powders, joint care)\n* Are pregnant, may be pregnant or breast-feeding\n* Currently experiencing, recovering or at a high risk of an eating disorder (e.g., previous diagnosis, or concerns that you have an unhealthy relationship with food)\n* Have a health condition, are taking medication and\u002For undergoing medical treatment that affects metabolism, appetite and\u002For ability to eat the calibration menu (e.g. cancer, chemotherapy, diabetes, gastrointestinal disorders (such as inflammatory bowel disease, Crohn's disease), kidney disease, liver disease, HIV or AIDS)\n* Are taking any of the following medications: androgens, blood thinners, phenytoin, erythromycin, or thyroid hormones\n* Long-term use of any of the following medications: anti-inflammatories (NSAIDS), steroids\u002Fcorticosteroids or antibiotics (eligible following a 4-week washout after short term use; eligible if use is infrequent)\n* Use illicit substances\u002Frecreational drugs\n* Have been diagnosed with dementia or other conditions affecting memory\n* Do not have anyone at home, work, etc. to help them if they require assistance to use the study tools (such as arthritis, Parkinson's disease, sight loss, etc.)\n\nIf the participants have recently taken part in another intervention study, a 4-week washout will be required before they are able to start the study.",{"count":208,"type":22},133,"OBSERVATIONAL","The aim of the SODIAT-2 study is to evaluate the effectiveness of dietary intake assessment tools in a real-world setting. These tools include wearable cameras, spot urine samples, capillary blood samples, and a web-based food frequency questionnaire (FFQ). The main questions it aims to answer are:\n\nIs the accuracy of dietary assessment improved in free-living environments when a combination of subjective and objective assessments tools are used?\n\nSecondary research questions are:\n\nCan wearable cameras accurately monitor the daily dietary intake of free-living individuals? Does a combination of capillary blood samples and spot urine samples provide a robust assessment of the nutrient status and habitual dietary exposure in a free-living setting? Can data-driven integration of multiple emerging technologies create a dietary assessment tool that is low burden, accurate and scalable in free-living populations? Can a condensed FFQ estimate diet quality as effectively as a detailed FFQ?\n\nParticipants will:\n\nUse the dietary assessment tools (wearable camera, spot urine, capillary blood, and eNutri FFQ web-app) as instructed over a 5-week period from their home and\u002For working space.\n\nTake part in two monitoring weeks (week 1 and week 5) where they will record their usual dietary intake over 3 days.\n\nConsume an identical 3-day study meal plan during the test (calibration) diet week 3, whilst repeating the monitoring week measurements.\n\nThis study aims to recruit 133 adults living in Great Britain (GB) to better understand how these tools perform outside of a clinical environment.",[212,213],"Dietary Intake Assessment","Food Intake Measurement",[215,216,217,218],"Nutrition","Health","Dietary reporting","Misreporting","2025-11-21",{"date":221,"type":39},"2025-11-28",{"date":223,"type":39},"2025-08-25",{"date":197,"type":22},{"name":45,"class":46},4,{"id":228,"slug":229,"hasResults":11,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":233,"eligibilityCriteria":234,"healthyVolunteers":55,"sex":17,"minAge":235,"maxAge":4,"enrollmentInfo":236,"targetDuration":4,"studyType":23,"phases":238,"briefSummary":239,"conditions":240,"keywords":241,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":247,"lastUpdatePostDateStruct":248,"startDateStruct":250,"completionDateStruct":252,"leadSponsor":254,"locationsCount":47},"100602152","investigating-the-effects-of-a-haskap-berry-supplement-on-cognitive-health-100602152","NCT07119788","Investigating the Effects of a Haskap Berry Supplement on Cognitive Health","Investigating the Cognitive, Vascular, and Metabolic Benefits of a Vitamin- and Mineral-Enhanced Haskap Berry Dietary Supplement","HACVAC","Inclusion Criteria:\n\n* 50+ years old\n* Fruit \\& veg intake less than or equal to 4 servings per day\n* Adequate English language and visual \\& auditory acuity to perform the cognitive tasks\n* Normal BMI for age\n\nExclusion Criteria:\n\n* Being diagnosed with psychological or psychiatric disorders\n* ADHD or dyslexia\n* Any food allergy or intolerance\n* Use of medications and dietary supplements that may impact study results\n* Antibiotic use within the last 3 months\n* Adherence to vegan or vegetarian diets, or other specific diets that may impact study outcomes\n* Conditions altering absorption of nutrients (e.g. celiac disease)\n* Being diagnosed with cardiometabolic disease (including type II diabetes and cardiovascular disease), or suffer from untreated hypertension or thrombosis related disorders\n* Taking blood thinners","50 Years",{"count":237,"type":22},90,[25],"This study aims to investigate the postprandial (2h) and longer term (4 week) effects of a haskap berry supplement on cognitive, vascular, and metabolic function in healthy ageing adults aged 50+.",[97],[97,242,243,244,245,246],"Mood","Stress","Vascular","Blood glucose","Haskap berries","2025-08-05",{"date":249,"type":39},"2025-08-13",{"date":251,"type":39},"2025-06-19",{"date":253,"type":22},"2026-04",{"name":45,"class":46},{"id":256,"slug":257,"hasResults":11,"nctId":258,"briefTitle":259,"officialTitle":259,"acronym":260,"eligibilityCriteria":261,"healthyVolunteers":11,"sex":17,"minAge":56,"maxAge":4,"enrollmentInfo":262,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":271,"lastUpdatePostDateStruct":272,"startDateStruct":274,"completionDateStruct":276,"leadSponsor":278,"locationsCount":47},"100593474","hair-isotope-analysis-for-early-cancer-detection-100593474","NCT07006909","Hair Isotope Analysis for Early Cancer Detection","HI-CARE","Inclusion Criteria:\n\nCancer diagnosis, sufficient hair\n\nExclusion Criteria:\n\n\\-",{"count":263,"type":22},20,"Cancer is a major health challenge, and early detection is crucial for improving patient outcomes. Research has shown that cancer can alter the way the body processes nutrients. This study aims to explore whether these metabolic changes can be detected through a simple, non-invasive method: analysing hair. Hair grows slowly over time, potentially capturing subtle metabolic changes that occur during cancer development. By studying the nitrogen stable isotope composition in hair samples donated by individuals diagnosed with cancer, we aim to identify potential early markers of the disease. Participants will be asked to donate a small strand of hair, which will be analysed using a laboratory technique called Isotope Ratio Mass Spectrometry (IRMS). The findings from this study could contribute to new, non-invasive screening tools for early cancer detection.",[266],"Cancer",[268,269,270],"cancer","hair","stable isotope ratio","2025-05-27",{"date":273,"type":39},"2025-06-05",{"date":275,"type":22},"2025-09-01",{"date":277,"type":22},"2030-05-30",{"name":45,"class":46},{"id":280,"slug":281,"hasResults":11,"nctId":282,"briefTitle":283,"officialTitle":284,"acronym":285,"eligibilityCriteria":286,"healthyVolunteers":55,"sex":17,"minAge":159,"maxAge":123,"enrollmentInfo":287,"targetDuration":4,"studyType":23,"phases":289,"briefSummary":290,"conditions":291,"keywords":292,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":296,"lastUpdatePostDateStruct":297,"startDateStruct":299,"completionDateStruct":301,"leadSponsor":303,"locationsCount":47},"100585291","the-effect-of-pistachio-rich-breakfast-meals-on-cognitive-function-in-healthy-older-adults-100585291","NCT06900452","The Effect of Pistachio-Rich Breakfast Meals on Cognitive Function in Healthy Older Adults","A Randomized Controlled Trial to Investigate the Cognitive, Vascular, Neural and Biochemical Effects of Acute Pistachio Intervention in Older Adults","PACVAN","Inclusion Criteria:\n\n* 65 - 80 years old\n* Fruit \\& veg intake less than or equal to 4 servings per day\n* Not regularly consuming more than 3 servings of fish per week\n* Adequate English language and visual \\& auditory acuity to perform the cognitive tasks\n* Normal BMI for age\n* Normal MMSE performance between 26-30\n\nExclusion Criteria:\n\n* Being diagnosed with psychological or psychiatric disorders\n* ADHD or dyslexia\n* Any food allergy or intolerance\n* Use of medications and dietary supplements that may impact study results\n* Antibiotic use within the last 3 months\n* Adherence to vegan or vegetarian diets, or other specific diets that may impact study outcomes\n* Being diagnosed with cardiometabolic disease (including type II diabetes and cardiovascular disease), or suffer from untreated hypertension or thrombosis related disorders\n* Taking blood thinners",{"count":288,"type":22},52,[25],"This study aims to investigate the effect of a breakfast meal containing varying serving sizes (doses) of pistachio nuts on cognitive function throughout the course of the day in healthy ageing adults aged 65-80.",[97],[97,293,244,294,295,242],"Pistachios","Neural","Inflammation","2025-05-02",{"date":298,"type":39},"2025-05-07",{"date":300,"type":39},"2025-03-06",{"date":302,"type":22},"2026-02",{"name":45,"class":46},{"id":305,"slug":306,"hasResults":11,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":311,"enrollmentInfo":312,"targetDuration":4,"studyType":23,"phases":314,"briefSummary":315,"conditions":316,"keywords":321,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":329,"lastUpdatePostDateStruct":330,"startDateStruct":332,"completionDateStruct":334,"leadSponsor":336,"locationsCount":47},"100574380","coffee-bioequivalence-trial-100574380","NCT06758531","Coffee Bioequivalence Trial","Coffee Bioequivalence Trial: Comparing the Pharmacokinetics of Bioactive Components and Physiological Effects of Consuming Encapsulated Instant Coffee Versus Traditional Instant Coffee Brewed in Water","Inclusion Criteria:\n\n* Healthy males and pre-menopausal females (must have regular menstrual cycles)\n* Aged between 18 to 45 years\n* Body mass index (BMI) between 18.5-30 kg\u002Fm2\n\nExclusion Criteria:\n\n* Sensitivity to coffee and caffeine\n* Food allergies relating to the test meals provided (such as gluten or lactose intolerance)\n* Current smoking and vaping use.\n* Medical history of chronic diseases (cancer, high blood pressure (hypertension), type 2 diabetes, heart attack and\u002For any other heart disease related diseases, gastrointestinal disorders, hyperlipidaemia, kidney or liver disease).\n* Diagnosed with anaemia\n* Prescribed any medication relating to the study outcome measures (such as blood pressure lowering, anti-inflammatories or blood thinners).\n* Drinking more than the recommended intake for alcohol (\\> 14 units\u002Fweek)\n* Taking any supplements (vitamins, minerals, probiotics).\n* Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study (e.g. pacemaker)\n* Planning on a weight-reducing regimen (lost \\>3 kg in the last 6 months)\n* Parallel participation in another intervention study\n* Pregnancy, planning a pregnancy in the next 6 months or breastfeeding\n* NHS blood donation in the last 3 months","45 Years",{"count":313,"type":22},16,[25],"The goal of this clinical trial is to test if coffee consumed as a tablet is biologically equivalent to that consumed traditionally as a drink. It will also learn about the impact of the short-term intake of coffee on markers of cardiovascular and liver health. The main questions it aims to answer are:\n\n* Do coffee bioactive compounds produce the same levels in blood and urine regardless of how the coffee is consumed (tablet or drink)?\n* How does coffee as a tablet or drink impact cardiovascular risk and liver health versus a non-coffee control?\n\nParticipants will:\n\n* Visit the clinical unit for three phases; each phase is 1x 480 minute (eight hour) acute postprandial visit and 1 x one hour visit the following day. During each phase they will be randomly assigned to take a different intervention (coffee drink, coffee tablet, coffee-free control)\n* Be cannulated during the 480 minute (8 hour) acute visits and have regular blood draws as well as basic clinical assessments\n* Return on day two for a fasting blood sample and basic clinical assessment\n* Collect their urine for 24 h\n* Be asked to record their intake of foods and drinks for 3 days to assess their usual diet (dietary assessment).",[317,318,319,320],"Liver Functions","Bioequivalence","Cardiovascular Risk","Cardiometabolic Risk Markers",[322,318,323,324,325,326,327,328],"Coffee","Caffeine","Liver function","Polyphenols","Blood pressure","Cardiovascular disease","Chlorogenic acids","2025-01-02",{"date":331,"type":39},"2025-01-03",{"date":333,"type":22},"2025-01",{"date":335,"type":22},"2025-12-30",{"name":45,"class":46},{"id":338,"slug":339,"hasResults":11,"nctId":340,"briefTitle":341,"officialTitle":342,"acronym":4,"eligibilityCriteria":343,"healthyVolunteers":55,"sex":17,"minAge":159,"maxAge":4,"enrollmentInfo":344,"targetDuration":4,"studyType":23,"phases":346,"briefSummary":347,"conditions":348,"keywords":350,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":355,"lastUpdatePostDateStruct":356,"startDateStruct":358,"completionDateStruct":359,"leadSponsor":361,"locationsCount":47},"100572990","investigating-the-effects-of-green-tea-on-blood-viscosity-100572990","NCT06740448","Investigating the Effects of Green Tea on Blood Viscosity","Investigating the Effects of Green Tea on Whole Blood Viscosity","Inclusion Criteria:\n\n* Participants ages 65 years and older\n* Non-smoker Participants with at least 2 'good' veins for giving blood\n\nExclusion Criteria:\n\n* Participants under (BMI \\\u003C18.5 kg\u002Fm2) or extremely over-nourished (BMI \\>30 kg\u002Fm2)\n* Participants on prescription medication for CVD or regularly taking blood thinning drugs such as aspirin.\n* Participants with a history of CVD or CVD in immediate family\u002F high resting blood pressure\n* Participants with any food allergies\u002Fintolerances\n* Participants with a history of metabolic diseases\u002F high resting blood glucose\n* Participants with high resting levels of inflammatory markers (CRP)\n* Participants on hormone replacement therapy\n* Participants with abnormal red blood cell count or low haemoglobin stores",{"count":345,"type":22},35,[25],"A diet high in flavonoids is becoming more established as beneficial to human health. Recent data suggest that the regular consumption of flavanols can reduce the numbers of deaths by cardiovascular disease at a population level. The mechanisms for these reductions in deaths by cardiovascular disease are still debated and little is known about their impacts on factors affecting blood viscosity. The metabolism of flavanols is complex, with different metabolites being predominant in the blood at different time points. Therefore, in this study, we will investigate the effects of green tea, a well-known source of flavanols, on blood viscosity at different time points. This will be assessed in healthy individuals with no history of cardiovascular disease aged 65+ years old. Blood viscosity will be measured before, and 2hours and 8hours after the consumption of green tea.",[349],"Cardiovascular Disease",[351,352,353,354],"Flavanol","Green Tea","Blood Viscosity","Older Adults","2024-12-19",{"date":357,"type":39},"2024-12-27",{"date":333,"type":22},{"date":360,"type":22},"2025-05",{"name":45,"class":46},{"id":363,"slug":364,"hasResults":11,"nctId":365,"briefTitle":366,"officialTitle":366,"acronym":4,"eligibilityCriteria":367,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":368,"enrollmentInfo":369,"targetDuration":4,"studyType":23,"phases":371,"briefSummary":372,"conditions":373,"keywords":376,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":381,"lastUpdatePostDateStruct":382,"startDateStruct":384,"completionDateStruct":386,"leadSponsor":388,"locationsCount":47},"100572827","investigating-the-impact-of-the-seaweed-derived-food-additive-carrageenan-on-the-human-gut-microbiome-100572827","NCT06738329","Investigating the Impact of the Seaweed Derived Food Additive, Carrageenan, on the Human Gut Microbiome","Inclusion Criteria:\n\n* Healthy individuals\n\nExclusion Criteria:\n\n* Prescribed antibiotics in the last 3 months\n* Individuals with any gut disorders such as IBS or IBD\n* individuals with any food allergies or intolerances\n* Individuals who regularly consume pre or probiotics","55 Years",{"count":370,"type":22},99,[25],"The goal of this study is to investigate whether a seaweed derived food additive, carrageenan, has an impact on the human gut microbiome in vivo. The primary purpose is to assess whether consumption of a carrageenan containing product for 4 weeks can alter the bacterial composition of the gut microbiome in healthy individuals and whether the addition of a prebiotic fibre, inulin, to the product has an enhanced beneficial impact of the gut composition. The main questions to answer are:\n\nDoes the consumption of a confectionary item containing carrageenan and inulin lead to a positive impact on the faecal microbial community when compared to the confectionary item containing no carrageenan and no inulin (placebo)? Participants will be asked to consume 2 gummy sweets for 4 week period and provide stool and urine samples on 3 occasions over a 9 week period.\n\nDoes the consumption of a confectionary item containing carrageenan and inulin improve gastrointestinal comfort measured using overall SHS-GI score when compared to baseline measurements recorded during run in period?",[374,375],"Gut Microbiome","Healthy Donors",[377,378,379,380],"Carrageenan","Gut microbiome","Gut health","food additive","2024-12-12",{"date":383,"type":39},"2024-12-17",{"date":385,"type":39},"2024-10-01",{"date":387,"type":22},"2025-05-30",{"name":45,"class":46},{"id":390,"slug":391,"hasResults":11,"nctId":392,"briefTitle":393,"officialTitle":394,"acronym":4,"eligibilityCriteria":395,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":18,"enrollmentInfo":396,"targetDuration":4,"studyType":209,"phases":4,"briefSummary":398,"conditions":399,"keywords":401,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":404,"lastUpdatePostDateStruct":405,"startDateStruct":407,"completionDateStruct":409,"leadSponsor":411,"locationsCount":4},"100505568","the-menus-of-change-health-and-heart-benefits-for-university-students-100505568","NCT05863078","The Menus of Change Health and Heart Benefits for University Students","The Menus of Change Health and Heart Benefits for University Students (The MOCHAHS Trial): a Cross-sectional Study","Inclusion Criteria:\n\n* Adults\n* Home students living in university halls\n* Undergraduates\n* Can understand participant information sheet and willing to comply with the study design\n\nExclusion Criteria:\n\n* International students\n* postgraduates\n* living outside the university halls\n* participating in other studies",{"count":397,"type":22},100,"The goal of this cross-sectional study is to investigate the health benefits of the Menus of Change in undergraduate university students, by comparing 2 groups: Students eating in the Menus of change catered halls, versus students eating outside the Menus of change meal plan. The main question it aims to answer is:\n\nWhat are the effects of the menus of change on other vascular outcomes, namely blood pressure? What are the effects of the menus of change on other health markers?",[400],"Healthy Lifestyle",[402,403],"Menus of Change","Arterial stiffness","2024-11-20",{"date":406,"type":39},"2024-11-22",{"date":408,"type":22},"2025-01-01",{"date":410,"type":22},"2026-12",{"name":45,"class":46},{"id":413,"slug":414,"hasResults":11,"nctId":415,"briefTitle":416,"officialTitle":417,"acronym":418,"eligibilityCriteria":419,"healthyVolunteers":55,"sex":17,"minAge":56,"maxAge":235,"enrollmentInfo":420,"targetDuration":4,"studyType":23,"phases":421,"briefSummary":422,"conditions":423,"keywords":427,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":440,"leadSponsor":442,"locationsCount":47},"100551950","the-impact-of-faba-bean-rich-bread-on-iron-status-postprandial-lipaemia-and-satiety-100551950","NCT06466746","The Impact of Faba Bean Rich Bread on Iron Status, Postprandial Lipaemia and Satiety","The Impact of Faba Bean Rich Bread on Iron Status, Postprandial Lipaemia and Satiety in Adults with Low Iron Stores","RtP","Inclusion Criteria:\n\n* Non-anaemic, males and pre-menopausal females (must have regular periods)\n* Aged 18-50 years old\n* BMI between 19 - 30 kg\u002Fm2\n* Low iron stores (serum ferritin between 13-40 µg\u002FL for females and 30-90 µg\u002FL for males)\n\nExclusion Criteria:\n\n* Food allergies or intolerances to faba beans (favism) or gluten\n* Diagnosed with anaemia (haemoglobin \\\u003C115 g\u002FL for females or \\\u003C130 g\u002FL for males) or haemochromatosis\n* C-reactive protein (\\>3mg\u002FL)\n* Smokers\n* A history of alcohol abuse (\\> 14 units\u002F week)\n* CVD or medical history of MI or stroke in the past 12 months\n* Diabetes (fasting glucose \\>7.0 mmol\u002FL)\n* Kidney, liver, pancreas or intestinal disease, gastrointestinal disorder or use of drugs likely to alter gastrointestinal function\n* Pregnancy, planning a pregnancy in the next six months or breastfeeding\n* Peri- and post-menopausal women or women with irregular periods\n* Planning on a weight-reducing regimen (lost \\>3kg in last 6 months)\n* Parallel participation in another intervention study\n* Hypertension (blood pressure \\> 140\u002F90 mmHg), cancer, taking medication for hyperlipidaemia (statins), or inflammation\n* Taking vitamin or mineral supplements\n* Donated blood in the last 3 months\n* Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study (such as a pacemaker)",{"count":313,"type":22},[25],"High levels of animal proteins (meat) in the diet are linked with a greater risk of developing heart disease and other long-term health conditions. Recently there has been a shift to plant-based diets including plant proteins such as pulses, defined as beans, peas, chickpeas and lentils. Pulses are a nutritious and sustainable form of plant protein which are rich in fibre and iron. Despite this, the UK population does not consume the recommended daily amount of pulses (80g\u002Fday equivalent to a large handful). In contrast, bread is commonly consumed but very little is known about how bread enriched with pulses influences the amount of iron that is digested and absorbed by the body as well as risk factors for developing heart disease and type 2 diabetes.\n\nThe main purpose of this randomised controlled cross-over study is to determine how consuming bread enriched with pulses (in the form of faba bean flour at approximately 40% enrichment) compared with conventional white bread (100% wheat flour) influences the amount of iron absorbed in healthy males and females aged 18-50 years with low iron stores. Secondary aims are determining the effects on blood fats and sugar (glucose) and on feelings of fullness (also known as satiety) after eating the bread enriched in pulses and conventional white bread.\n\nParticipants will be required:\n\n* To attend for seven study visits over a period of 60 days.\n* Consume a breakfast meal containing either the faba bean-enriched bread or conventional bread over two study periods, each consisting of one 7 hour study visit and two consecutive visits of 2 hours in duration. After 28 days, participants will return for the second study period as above, with a final study visit conducted 28 days later.\n* Give blood samples during 2 x 7 hour study visits\n* Complete visual analogue scales to rate appetite after consuming the faba bean-enriched and conventional white bread.\n* Record dietary intake prior to and during the study period.",[424,425,426],"Anemia, Iron Deficiency","Cardiometabolic Disease","Low Iron Stores",[428,429,430,431,432,433,434],"faba bean enriched bread","bioavailability","Enrichment of blood haemoglobin with Iron-57 stable isotope","Postprandial Lipaemia","Satiety","Visual analogue scales","Postprandial glycaemia","2024-09-11",{"date":437,"type":39},"2024-09-19",{"date":439,"type":22},"2024-09",{"date":441,"type":22},"2025-09",{"name":45,"class":46},{"id":444,"slug":445,"hasResults":11,"nctId":446,"briefTitle":447,"officialTitle":448,"acronym":449,"eligibilityCriteria":450,"healthyVolunteers":55,"sex":17,"minAge":235,"maxAge":123,"enrollmentInfo":451,"targetDuration":4,"studyType":23,"phases":453,"briefSummary":454,"conditions":455,"keywords":456,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":460,"lastUpdatePostDateStruct":461,"startDateStruct":463,"completionDateStruct":465,"leadSponsor":467,"locationsCount":468},"100560948","black-rice-consumption-on-cognitive-function-inflammation-and-microvascular-function-in-older-adults-100560948","NCT06583785","Black Rice Consumption on Cognitive Function, Inflammation and Microvascular Function in Older Adults","Impact of Anthocyanin-Rich Black Rice Consumption on Cognitive Function, Inflammation and Micro-vascular Function in Older Adults","RICE","Inclusion Criteria:\n\n* Aged 50-80 years\n* General healthy status\n* Body Mass Index (BMI)18.5-35 kg\u002Fm2\n\nExclusion Criteria:\n\n* Taking anti-inflammatory drugs (e.g., aspirin, warfarin, ibuprofen)\n* Having sign of infections or acute inflammation (e.g., fever, chills, sore throat, nasal congestion, moderate-severe pain, swelling-redness)\n* Received antibiotics within the past 3 months\n* Taking dietary supplements (e.g., vitamins, minerals) at high doses (e.g., more than 200% of the UK's reference nutrient intakes)\n* Taking hormone replacement therapy, if you are menopausal\n* Had major surgery (head, heart, chest, abdomen) within the past 6 months.\n* Having plan to start to a restricted diet\u002F changing dietary pattern or lose weight.\n* Diagnosed with neurodegenerative diseases (e.g., Dementia, Alzheimer's, Parkinson's, current stroke)\n* Diagnosed with psychotic disorders (e.g., schizophrenia, bipolar depression, eating disorder)\n* Diagnosed with cardiovascular disease, diabetes, hyperlipidemia, hypertension (blood pressure\\>140\u002F90 mmHg), active cancer, liver, or kidney diseases.\n* Taking medication to lower blood fats (e.g., statins, fibrates) or to stabilise blood glucose (e.g., acarbose, metformin or sulfonylureas) or lower blood pressure.\n* Unable to complete the cognitive function tasks for any reason (i.e., visual impairments, hearing loss)\n* If you have a peacemaker\n* If you have bleeding disorders or blood related diseases (anaemia, thalassemia, thrombosis, embolism)\n* Heavy smoker\n* Heavy alcohol drinking (\\> 14 units\u002Fweek) or a history of alcohol\u002Fsubstance abuse\n* Allergies, hypersensitivity, or food intolerances (rice, eggs, soy sauce, vegetable oil)",{"count":452,"type":22},24,[25],"Cognitive (brain) function, especially memory, gradually declines during ageing, which may in part be caused by an increase in systemic inflammation as well as a reduction in vascular functions and cerebral blood flow. Blood inflammatory mediators such as c-reactive protein (CRP) and interleukin-6 (IL-6) found to be significantly higher among people over 65 years compared to younger age groups.\n\nAnthocyanins is water-soluble compounds giving blue, purple and red colours in fruits and vegetables. Anthocyanins have been demonstrated to improve cognitive function, inhibit inflammation, and protect cardiovascular health. Black rice contains high amounts of anthocyanins mainly cyanidin 3-glucoside and peonidin 3-glucoside as well as various nutritional compounds such as carbohydrate, vitamin B, vitamin E and fibre. Previous studies reported health benefits of black rice, including anti-inflammation, antioxidative stress, anti-diabetes, and improved cognitive function. However, the effect of black rice consumption on cognitive function related to inflammation has not been studied in humans.\n\nTherefore, this study aims evaluate the acute \\& short-term effects of black rice consumption on the cognitive function, inflammation, and vascular function in older adults aged 50-80 years.\n\nThe primary and secondary research questions of this study will address:\n\n1. Do the acute and short-term anthocyanin-rich black rice intakes improve cognitive function in older adults aged 50-80 years?\n2. Do the acute and short-term anthocyanin-rich black rice intakes modulate inflammatory status and microvascular function in older adults aged 50-80 years?",[354],[457,295,458,459],"Cognitive function","Memory","Older adults","2024-09-03",{"date":462,"type":39},"2024-09-04",{"date":464,"type":39},"2023-12-05",{"date":466,"type":22},"2024-12-31",{"name":45,"class":46},2,{"id":470,"slug":471,"hasResults":11,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":475,"eligibilityCriteria":476,"healthyVolunteers":55,"sex":477,"minAge":56,"maxAge":235,"enrollmentInfo":478,"targetDuration":4,"studyType":23,"phases":479,"briefSummary":480,"conditions":481,"keywords":482,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":491,"completionDateStruct":493,"leadSponsor":495,"locationsCount":47},"100492954","mapping-the-impact-of-gut-microbiota-on-brain-and-behavior-through-the-lens-of-gaba-100492954","NCT05698862","Mapping the Impact of Gut Microbiota on Brain and Behavior Through the Lens of GABA","Mapping the Impact of Gut Bacteria on Brain and Behaviour Through the Lens of GABA (GutBrainGABA)","GutBrainGABA","Inclusion Criteria:\n\n* Male\n* Right-handed\n* Caucasian\u002FWhite\n* Between 18 and 50 years of age\n* Grew up in the UK or other European country\n* Body Mass Index 18.5 to 30.\n\nExclusion Criteria:\n\n* Use of antibiotics within the last 3 months\n* Use of protonic pump inhibitors (PPIs) within the last 3 months\n* Current or history of regular smoking within the last 6 months\n* Regular consumption of \\>14 units of alcohol per week\n* Current use of psychotropic drugs for medicinal or recreational purposes\n* Current use of probiotic\u002Fprebiotic supplements\n* Current diagnosis of neurological, developmental or psychiatric condition\n* Current diagnosis of gut microbiota related conditions such as inflammatory bowel disease or irritable bowel syndrome","MALE",{"count":125,"type":22},[25],"Gut microbiota produce different metabolites within the human body, which include neurotransmitters. Animal studies have demonstrated a critical role for the gut microbiota in various aspects of brain and behavioural function, and a smaller number of studies in humans have shown differences of gut microbiota composition in psychiatric conditions. However, almost nothing is known about the impact of neurotransmitters produced by the gut microbiota on human brain and behaviour.\n\nThe way in which differences in brain, behaviour and personality traits are associated with the gut microbiota, and how they are influenced by a probiotic will be explored, with a special focus on GABA (Gamma Amino Butyric Acid).\n\nAbnormalities of microbiota composition have been identified in metabolic disorders, such as inflammatory bowel disease and obesity, and psychiatric conditions, such as depression and anxiety.\n\nThe aim of this intervention trial will be to answer the following fundamental questions:\n\n1. Does the population of gut bacteria capable of producing GABA modulate brain-based measures of GABA?\n2. Does the population of gut bacteria capable of producing GABA influence performance in behavioural tasks known to depend on GABA-ergic function?\n\nThe impact of a GABA producing probiotic on the measures of GABA in the brain and serum, relevant metabolites in blood, faecal and urine samples and performance in GABA dependent behavioural tasks will be investigated in this trial.",[165],[483,484,485,486,487],"Gamma Amino Butyric Acid (GABA)","Brain function","Gut microbiota","Behaviour","Probiotics","2023-01-16",{"date":490,"type":39},"2023-01-26",{"date":492,"type":39},"2022-05-21",{"date":494,"type":22},"2026-12-31",{"name":45,"class":46},""]