[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Rhode Island\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":160},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,48,85,114,138],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":19,"enrollmentInfo":20,"targetDuration":4,"studyType":23,"phases":24,"briefSummary":26,"conditions":27,"keywords":29,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100547592","feasibility-and-acceptability-of-mindful-self-compassion-among-transgender-and-nonbinary-young-adults-100547592",false,"NCT06409975","Feasibility and Acceptability of Mindful Self-Compassion Among Transgender and Nonbinary Young Adults","Evaluating the Feasibility and Acceptability of Mindful Self-Compassion Among Transgender and Nonbinary Young Adults","Inclusion Criteria:\n\n* transgender, nonbinary, genderqueer (or another non-cisgender identity)\n* have reliable access to a smart phone or computer\u002Ftablet and the Internet and is reasonably able to make the time commitment required of the program (self-report)\n* speak and understand English\n\nExclusion Criteria:\n\n* has had formal mindfulness training (i.e. mindfulness-based stress reduction course) or engages in regular mindfulness practice (15 minutes more than twice a week for the last six months or more)\n* Score 15 or higher on the patient health questionnaire-8 (PHQ-8)\n* Score 2 or higher on the Columbia Suicide Severity Rating Scale\n* Experienced an acute physical health crisis (e.g., chemotherapy, recovery from severe injury) (Germer \\& Neff, 2019, p. 80) in the past year\n* Head trauma, seizure, or loss of consciousness in the past 6 months\n* Reports a history of trauma AND Scores 14 or higher on Post-Traumatic Checklist, 6-item Civilian version\n* Reports a diagnosis of a personality disorder\n* Reports a diagnosis of schizophrenia or a history of psychosis\n* Reports acute panic attack in the past month and history of acute panic attacks with concern\u002Fworry about having another one in the future OR Reports severe social anxiety which would make attending class too difficult\n* Reports an acute episode of psychosis or suicide attempt in the past 12 months\n* Has engaged in non-suicidal self-injury in the past 6 months\n* Currently prescribed antipsychotic medications, benzodiazepine (equivalent to 30mg diazepam\u002Fday) or opioids (\\>40mg morphine equivalent\u002Fday)\n* Prescribed any other psychiatric medication, including medication for opioid use disorder, whose dose has been changed in the past 8 weeks or is anticipated to change in the next 2 months.\n* Currently engage in harmful drinking (5 or more drinks on one occasion (Flentje et al., 2020) more than once in the past 2 weeks; OR have any concerns about the expectation to not be using substances during group sessions\n* has undergone detoxification from alcohol or other drugs and has been in sustained remission (with or without medication) for less than 1 year\n* Has been hospitalized overnight for mental health related reasons in the past year (any diagnoses except bipolar disorder) OR have a diagnosis of bipolar disorder and have had an episode of mania or have been hospitalized in the past 2 years\n* Reports any other acute physical or mental illness symptoms that may make group participation difficult",true,"ALL","18 Years","29 Years",{"count":21,"type":22},50,"ESTIMATED","INTERVENTIONAL",[25],"NA","The goal of this single-arm feasibility study is to evaluate the feasibility and acceptability of an 8-week mindful self-compassion intervention and associated data-collection plan among transgender and nonbinary young adults. Participants will be asked to:\n\n* Complete weekly 2.5-hour virtual classes for 8 weeks and a 4-hour virtual retreat\n* Practice specific activities in between classes for 20-30 minutes a day\n* Answer survey questions before starting the intervention, half-way through the intervention, after the intervention, and 3-months after the intervention ends.",[28],"Healthy",[30,31,32,33,34],"transgender","nonbinary","mindful self-compassion","feasibility","acceptability","RECRUITING","2026-06-08",{"date":38,"type":39},"2026-06-11","ACTUAL",{"date":41,"type":39},"2025-06-12",{"date":43,"type":22},"2028-08-30",{"name":45,"class":46},"University of Rhode Island","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":16,"sex":17,"minAge":56,"maxAge":57,"enrollmentInfo":58,"targetDuration":4,"studyType":23,"phases":59,"briefSummary":61,"conditions":62,"keywords":71,"overallStatus":75,"whyStopped":4,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},"100639368","phase-2-use-of-bile-acid-binding-resins-to-decrease-pfas-levels-via-colesevalem-in-veterans-study-100639368","NCT07592858","Use of Bile Acid Binding Resins to Decrease PFAS Levels Via Colesevalem in Veterans Study","Use of Bile Acid Binding Resins to Decrease Systemic Per- and Polyfluoroalkyl Substance (PFAS) Levels and Improve Serum Lipid Profiles in Veterans: PFAS Reduction in Veterans Via Colesevalem Study (PAVERS) Study","PAVERS","Inclusion:\n\n* Male or female Veterans aged 25- 65 who have serum PFAS \\>20 ng\u002Fml exceeding National Academy of Science guidance.\n* Written informed consent will be obtained.\n* Outpatient.\n* Agreeable to participate in sharable data and biorepository.\n\nExclusion:\n\n* Under the age of 25 years\n* Unable or unwilling to sign the informed consent statement and HIPAA Authorization form\n* Females who are pregnant (confirmed by urine pregnancy test), nursing or planned pregnancy within study period.\n* Patients with hypertriglyceridemia, vitamin deficient patients, hyperthyroidism and diabetic, pancreatitis and intestinal and bowel obstruction\n* Be receiving any investigational drug other than Colesevelam or participating in any other investigational study.\n* Significant medical illnesses that may limit the subject's ability to complete follow-up visits, in the opinion of the investigator.\n* Be receiving any non-standard immunosuppression protocol or other non-standard treatment that could affect interpretation of the study results.\n* Those with significant cardiovascular disease including treatment with inotropes.\n* Presence of a condition or abnormality that in the opinion of the Investigator would compromise the safety of the patient or the quality of the data.\n* Active substance abuse if this, in the opinion of the investigator, will interfere with the subject's ability to adhere to the study protocol.","25 Years","65 Years",{"count":21,"type":22},[60],"PHASE2","The goal of this study is to test the efficacy and feasibility of Colesevelam administration (50% of the recommended dose) to reduce serum PFAS concentration in the Veteran population who have serum PFAS levels that exceed the National Academies Science criteria (PFASsix \\> 20 ng\u002Fml) using a double blind-placebo controlled study. Based on PFAS prevalence in serum samples, we anticipate recruiting up to n=500 Veterans to meet the goal of n=50 study participants to receive intervention or placebo. The primary outcome will be initial and final PFAS content in serum (total and 7 individual PFAS). The secondary outcome will be initial and final serum biomarkers related to lipid metabolism. As an exploratory aspect to the proposal, we will also measure fecal PFAS, bile acids, and microbial diversity to examine associations between PFAS content and bile acid levels and microbiome. Fecal PFAS, bile acid content, and microbiome may also be measured.",[63,64,65,66,67,68,69,70],"PFAS","Environmental Exposures","Occupational Exposure to Chemicals","Military Exposure","Burn Pit Exposure","Forever Chemicals","Hyperlipidemias, Hypercholesterolemia, Mixed Dyslipidemia","Hyperlipidemia (E.G., Hypercholesterolemia)",[63,72,73,74],"Military exposure","Forever chemicals","Colesevelam","NOT_YET_RECRUITING","2026-05-11",{"date":78,"type":39},"2026-05-18",{"date":80,"type":22},"2026-07-01",{"date":82,"type":22},"2029-09-29",{"name":45,"class":46},3,{"id":86,"slug":87,"hasResults":11,"nctId":88,"briefTitle":89,"officialTitle":90,"acronym":91,"eligibilityCriteria":92,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":93,"targetDuration":4,"studyType":23,"phases":95,"briefSummary":96,"conditions":97,"keywords":100,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":106,"lastUpdatePostDateStruct":107,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":47},"100609685","recovery-through-inhibitory-learning-self-efficacy-building-problem-solving-and-community-building-100609685","NCT07217795","Recovery Through Inhibitory Learning, Self-Efficacy Building, Problem Solving, and Community Building","Developing a Telehealth Intervention for Alcohol and Trauma Among LGBTQ+ People","RISE","Aim 1: Sexual Minority Women and Transgender and Gender Diverse Individuals -Not meeting inclusion criteria\n\nAim 1: Providers\n\n-Not meeting inclusion criteria\n\nAim 2: Sexual Minority Women and Transgender and Gender Diverse Individuals\n\n* Not meeting inclusion criteria OR any of the following:\n* Reporting current mental health treatment ≥1 day\u002Fmonth\n* Receiving Cognitive Behavioral Therapy (CBT) in the past 3 months (note: participants are not ineligible if they seek concomitant care after enrollment)\n* Reporting current alcohol or drug use disorder treatment, except mutual self-help (e.g., Alcoholics Anonymous) or current PTSD\u002Ftrauma-focused treatment\n* Need for alcohol detoxification, defined as score ≥15 on the adapted self-report Clinical Institute Withdrawal Assessment for Alcohol - Revised (CIWA-Ar)\n* Active psychosis, defined as score ≥1 on the psychosis subscale of the Behavior and Symptom Identification Scale - Revised (BASIS-R)\n* Active mania, defined as score ≥6 on the Altman Self-Rating Mania Scale (ASRM)\n* Active suicidality, defined as score ≥22 on the Suicidal Ideation Attributes Scale (SIDAS)\n* Currently legally mandated to attend treatment",{"count":94,"type":22},80,[25],"This is a two-part study to develop and test a brief, virtual therapy program for lesbian, gay, bisexual, transgender, and queer (LGBTQ+) people who have experienced trauma and use alcohol.\n\nPhase 1: You'll be invited to share your perspective to help make the program relevant, inclusive, and affirming.\n\nPhase 2: You may have the opportunity to try the adapted program by receiving free virtual therapy with LGBTQ+-affirming therapists.",[98,99],"Alcohol Use Disorder (AUD)","PTSD",[101,102,103,99,104,105],"LGBTQ","cognitive behavioral therapy","expressive writing","alcohol use","telehealth","2025-12-01",{"date":108,"type":39},"2025-12-09",{"date":110,"type":39},"2025-11-30",{"date":112,"type":22},"2028-09",{"name":45,"class":46},{"id":115,"slug":116,"hasResults":11,"nctId":117,"briefTitle":118,"officialTitle":118,"acronym":119,"eligibilityCriteria":120,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":121,"enrollmentInfo":122,"targetDuration":4,"studyType":23,"phases":124,"briefSummary":125,"conditions":126,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":47},"100467217","development-of-a-culturally-grounded-trauma-informed-alcohol-intervention-with-a-reserve-dwelling-first-nation-group-100467217","NCT05363878","Development of a Culturally Grounded, Trauma-Informed Alcohol Intervention With a Reserve-Dwelling First Nation Group","NativeHEALTH","Inclusion Criteria:\n\n* At least 18 years of age\n* Used alcohol in the past week\n* Self-identify as a First Nation member\n* Reside within the partner community\n* Want to cut down or stop alcohol use\n\nExclusion Criteria:\n\n* Experiencing current psychotic symptoms\n* High scores (\\>10) on the Clinical Institute Withdrawal Assessment for Alcohol, Revised","90 Years",{"count":123,"type":22},60,[25],"The objective of this project is to develop and obtain preliminary data on a culturally grounded, trauma-informed alcohol intervention. The specific aims are to (1) use Community-Based Participatory Research methods to deepen partnerships with First Nation through capacity-building and knowledge sharing; (2) collect and apply qualitative data to develop a culturally grounded, trauma-informed alcohol intervention that is focused on historical trauma for use with a First Nation sample; and (3) conduct a pilot RCT study to examine acceptability, sustainability, and initial efficacy data of the intervention compared to waitlist control. This work is important, timely, and innovative. Addressing alcohol use has important implications for the health of Indigenous populations.",[127,128,129],"Alcohol Drinking","Trauma, Psychological","Historical Trauma","2025-04-21",{"date":132,"type":39},"2025-04-24",{"date":134,"type":39},"2025-01-13",{"date":136,"type":22},"2025-09-29",{"name":45,"class":46},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":142,"acronym":4,"eligibilityCriteria":143,"healthyVolunteers":16,"sex":17,"minAge":144,"maxAge":145,"enrollmentInfo":146,"targetDuration":4,"studyType":23,"phases":147,"briefSummary":148,"conditions":149,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":152,"lastUpdatePostDateStruct":153,"startDateStruct":155,"completionDateStruct":157,"leadSponsor":159,"locationsCount":47},"100468513","developing-a-positive-approach-to-substance-use-prevention-in-north-american-indian-adolescents-100468513","NCT05380765","Developing a Positive Approach to Substance Use Prevention in North American Indian Adolescents","Inclusion Criteria - Youth Participants:\n\n1. residing in the First Nation community,\n2. identify as a member of a First Nation,\n3. be in grades 5th - 8th at time of enrollment, and\n4. one youth per household may participate.\n\nInclusion Criteria - Family Participants:\n\n1. at least 18 years of age\n2. reside within the First Nation community\n3. be identified, by the youth, as an important influence in their life\n4. be committed to helping the youth make good decisions regarding using substances","10 Years","14 Years",{"count":123,"type":22},[25],"The overall objective of this project is to develop and obtain preliminary data on acceptability, feasibility, and initial efficacy of Native PATHS. This work is guided by the stage model guidelines for treatment development and adaptation 25. Stage 1a will occur in two sequential steps. First, the investigators will recruit youth who are in 5th - 8th grade and their family members (N=24, 12 youth, 12 adults 18+) to participate in three talking circle sessions to obtain feedback on the cultural adaptation and implementation of the treatment. Next, the investigators will conduct an open label pilot (N=9). Youth and their family members, (up to 3 per youth) will provide qualitative and quantitative feedback after each session. In Stage 1b, 60 youth will participate in a pilot randomized controlled trial, testing the efficacy of the newly created program (n=30) against a wait list control (WLC) condition (n=30). Ultimately, this program of research is expected to result in a well-specified, efficacious prevention program that could be readily disseminated and generalizable to other Indigenous populations with minimal adaptation.",[127,150,151],"Tobacco Use","Drug Use","2024-06-04",{"date":154,"type":39},"2024-06-05",{"date":156,"type":22},"2024-06-17",{"date":158,"type":22},"2025-05-31",{"name":45,"class":46},""]