[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Roehampton\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":128},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,4,0,[8,47,79,100],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100636437","the-balance-study---improving-glucose-control-through-prebiotic-gut-health-drink-in-postmenopausal-women-100636437",false,"NCT07565675","The BALANCE Study - Improving Glucose Control Through Prebiotic Gut Health Drink in Postmenopausal Women","Improving Glucose Control Through Prebiotic Gut Health Drink in Postmenopausal Women","BALANCE","Inclusion Criteria::\n\n* Female, aged 45-60 years\n* Post-menopausal (no menstrual period for ≥12 months)\n* No serious long-term medical conditions\n* Living in the UK\n* Able to read English and provide electronic informed consent\n* Willing and able to comply with study procedures, including dietary intervention and sample collection\n* Willing to provide stool samples at specified time points\n* BMI ≥25 kg\u002Fm² with one of the following:\n\n  * Impaired glucose tolerance (7.8-11.0 mmol\u002FL at 2-hour OGTT), or\n  * Impaired fasting glucose (5.6-6.9 mmol\u002FL), or\n  * HbA1c 5.7%-6.4%\n* No intentional dieting within the past month\n* No \\>5% body weight loss in the past year\n* No changes in physical activity in the past 2-4 weeks and no intention to change during the study\n\nExclusion Criteria:\n\n* Significant gastrointestinal disease (e.g., inflammatory bowel disease, coeliac disease) or other major medical conditions affecting gut microbiota or study safety\n* Immunocompromised status or other serious chronic illness\n* Use of antibiotics within the past 2-3 months\n* Regular use of probiotics or prebiotics within the past 4 weeks\n* Use of medications or special diets that significantly affect gut microbiota (e.g., chronic laxatives, immunosuppressants)\n* Known allergies or intolerances to components of the prebiotic formulation\n* Participation in another interventional clinical trial within the past 3 months",true,"FEMALE","45 Years","60 Years",{"count":22,"type":23},30,"ESTIMATED","INTERVENTIONAL",[26],"NA","The menopausal transition is associated with a decline in oestrogen levels, contributing to adverse metabolic changes including increased central adiposity, systemic inflammation, and insulin resistance. These changes are linked to a higher risk of developing type 2 diabetes in postmenopausal women.\n\nRecent evidence suggests that the gut microbiota plays an important role in metabolic regulation and glucose homeostasis. Menopause-related hormonal changes may alter the composition and function of the gut microbiome, with downstream effects on insulin sensitivity. Additionally, certain gut bacteria (i.e., Bifidobacterium species) regulate circulating oestrogen via β-glucuronidase activity, highlighting a potential interaction between microbial composition and hormonal balance. Observational findings support associations between menopausal stage, gut microbiota alterations, and insulin homeostasis.\n\nPrebiotics are non-digestible compounds that selectively stimulate beneficial gut bacteria and may improve metabolic outcomes. Modulation of the gut microbiota through prebiotic supplementation represents a promising non-pharmacological strategy to improve glucose control. Multiple studies have demonstrated that inulin (a common prebiotic) can improve glucose regulation and aid weight loss in individuals with obesity, prediabetes, or type 2 diabetes. However, to date, no randomised controlled trials have specifically investigated prebiotic supplementation in postmenopausal women with prediabetes using dynamic measures such as the Oral Glucose Tolerance Test (OGTT).\n\nThe present study aims to investigate the effect of daily consumption of an inulin-containing prebiotic gut health drink (ió everyday) on glucose control in postmenopausal women with prediabetes. The primary objective is to determine whether the intervention improves glycaemic control. Secondary objectives include exploration of changes in metabolic markers and assessment of the role of the gut microbiota in mediating these effects.\n\nIt is hypothesised that consumption of ió everyday will improve glucose control in prediabetic women who have recently undergone menopause. This hypothesis is supported by evidence demonstrating that inulin and soluble corn fibre can improve glucose regulation and support weight management in individuals with obesity, prediabetes, or type 2 diabetes, as well as findings from a previous study (Ethics Ref ID: LSC 23\u002F383), which demonstrated that one month of ió everyday consumption significantly reduced fasting glucose, with a trend towards weight reduction and no reported adverse effects.",[29],"Menopause",[31,32,33],"menopause","diabetes","obesity","NOT_YET_RECRUITING","2026-05-27",{"date":37,"type":38},"2026-05-28","ACTUAL",{"date":40,"type":23},"2026-06-10",{"date":42,"type":23},"2027-05-15",{"name":44,"class":45},"University of Roehampton","OTHER",1,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":17,"sex":18,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":24,"phases":58,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":46},"100596173","effectiveness-of-nutritional-resources-for-milk-donors-100596173","NCT07042009","Effectiveness of Nutritional Resources for Milk Donors","inVestigating the effectIveness of nuTritionAl Information Resources for MIlk doNors","VITAMIN","Inclusion Criteria:\n\n• New donors from the Countess of Chester Hospital milk bank\n\nExclusion Criteria:\n\n* Insufficient comprehension of English to understand the information sheet and consent form and complete the questionnaires\n* Currently taking omega-3 PUFA dietary supplements providing greater than 200 mg DHA per day\n* Body Mass Index (BMI) ≥30 kg\u002Fm2","18 Years",{"count":57,"type":23},60,[26],"Maternal diet influences breast milk nutritional profile; however, a national survey undertaken by the researchers revealed that non-for-profit donor milk banks in the U.K. do not provide specific dietary information to donors. Moreover, the researchers have shown that donor milk in the U.K. provides very low levels of the omega-3 and omega-6 polyunsaturated fatty acids (PUFAs), docosahexaenoic acid (DHA) and arachidonic acid, respectively. These are essential for brain development and immune system function, and preterm infants receiving donor milk do not receive sufficient levels of these nutrients. There is therefore an urgent need to develop nutritional guidelines and resources for milk donors.\n\nFollowing a systematic review the researchers developed evidence-based nutritional information resources for donors, which would also be applicable more generally to lactating mothers. Those resources were developed in consultation with donors, and healthcare professionals, including dietitians and lactation consultants.\n\nResearchers will evaluate the effectiveness of these resources in terms of acceptance and compliance, and also changes in milk DHA content. The researchers will also assess whether providing feedback on individual's milk DHA content increases milk DHA levels. If successful these resources will be introduced into milk banks across the U.K., and promoted to the wider breastfeeding community.",[61,62],"Docosahexaenoic Acid Content of the Participants","Docosahexaenoic Acid Content of the Breast Milk",[64,65,66,67,68,69],"omega-3 fatty acids","donor human milk","human milk bank","preterm infants","DHA","docosahexaenoic acid","RECRUITING","2026-05-18",{"date":73,"type":38},"2026-05-20",{"date":75,"type":38},"2026-04-02",{"date":77,"type":23},"2026-10-31",{"name":44,"class":45},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":83,"acronym":4,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":85,"minAge":55,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":24,"phases":88,"briefSummary":89,"conditions":90,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":46},"100626475","evaluating-the-impact-ai-avatar-led-mental-health-interventions-for-keeping-employees-in-work-100626475","NCT07436117","Evaluating the Impact AI Avatar-led Mental Health Interventions for Keeping Employees in Work","Inclusion Criteria:\n\n* Participants will be eligible if they currently experience symptoms of depression (score above 5 on the PHQ-9)\n* Participants should be aged 18 or above.\n* Participants need to be resident in the UK.\n\nExclusion Criteria:\n\n* Participants with frequent thoughts of suicide\u002Fself-harm will be excluded (scoring above 2 on Question 9 of the PHQ-9 \"Thoughts that I would be dead or hurting myself in some way\")\n* Participants who are currently undergoing other forms of therapy will be excluded.","ALL",{"count":87,"type":23},50,[26],"This study will examine whether an artificial intelligence (AI) avatar-led mental health programme can help employees experiencing symptoms of depression. The programme delivers structured, self-guided psychological support over several short sessions that participants complete online over a period of several weeks.\n\nApproximately 50-80 adults will take part. Participants will be randomly assigned either to start the AI programme immediately or to continue with their usual support and access the programme later. All participants will complete questionnaires before and after the study period to assess changes in mood, anxiety, and work functioning. Some participants will also be invited to take part in brief interviews to share their experiences of using the programme.\n\nThe aim of the study is to evaluate whether this AI-based intervention can improve mental health and workplace functioning, and to assess how acceptable and safe it is for use in a working population.",[91],"Depression","2026-02-20",{"date":94,"type":38},"2026-02-27",{"date":96,"type":38},"2025-10-07",{"date":98,"type":23},"2026-06-30",{"name":44,"class":45},{"id":101,"slug":102,"hasResults":11,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":11,"sex":85,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":24,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":127},"100603603","promoting-mental-health-among-at-risk-adolescents-in-malaysia-100603603","NCT07138664","Promoting Mental Health Among At-risk Adolescents in Malaysia","MyHeRo","Inclusion Criteria:\n\n1. Adolescent (aged 12-14) who are in the first two years (Form 1 and Form 2, equivalent to year 7 and 8 in the United Kingdom school system, respectively) in lower secondary schools.\n2. Adolescents score moderate to severe levels of anxiety and\u002For depression on the Depression Anxiety and Stress Scale-21 (DASS-21) based on the original cut-off norms (DASS-21 Anxiety scale ≥ 10 and\u002For DASS-21 Depression scale ≥ 14).\n3. Adolescent's parent\u002Fcarer provides written consent.\n\nExclusion Criteria:\n\n(1) Being diagnosed with neurodevelopmental disorders. (2) Being diagnosed with intellectual disability.\n\n\\-","12 Years","14 Years",{"count":110,"type":23},428,[26],"The primary objective of this trial is to evaluate a school-based intervention designed to promote mental health among at-risk adolescents from low-income communities in Malaysia. The study will employ a two-arm, cluster randomised controlled trial design, comparing a school-based intervention to a control condition. Adolescents will be recruited from at least 20 secondary schools located in economically disadvantaged rural and urban areas of Malaysia. Assessments will take place at multiple time points: during screening, at baseline (pre-intervention), immediately after the intervention (8 weeks), and at two follow-up points-6 and 12 months post-intervention. The primary outcomes are a reduction in anxiety and depressive symptoms, along with improved mental wellbeing at the 12-month follow-up.",[114,115],"Depression in Adolescence","Anxiety",[115,91,117,118],"Adolescents","School-based intervention","2025-08-16",{"date":121,"type":38},"2025-08-24",{"date":123,"type":23},"2025-08",{"date":125,"type":23},"2026-09",{"name":44,"class":45},5,""]