[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Salamanca\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":668},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,49,79,114,138,168,200,222,240,261,284,313,341,370,394,419,442,469,494,520,539,567,590,618,639],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":37,"lastUpdatePostDateStruct":38,"startDateStruct":41,"completionDateStruct":43,"leadSponsor":45,"locationsCount":48},"100641692","neurofeedback-for-episodic-migraine-100641692",false,"NCT07661888","Neurofeedback for Episodic Migraine","Effectiveness of Neurofeedback for Reducing the Frequency and Severity of Episodic Migraine","Inclusion Criteria:\n\n* Adults aged ≥18 years\n* Diagnosis of episodic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), with or without aura.\n* History of medium to high-frequency episodic migraine, defined as 5-14 migraine days per month during the 3 months prior to enrollment.\n* Ability and willingness to provide written informed consent.\n\nExclusion Criteria:\n\n* Diagnosis of chronic migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), defined as ≥15 headache days per month for more than 3 months, with at least 8 migraine days per month.\n* History of severe psychiatric disorders (e.g., schizoaffective disorder, bipolar disorder, major depressive episode with psychotic features, or other non-organic psychotic disorders) requiring psychiatric treatment within the 6 months prior to enrollment.\n* History of brain injury or other neurological conditions that contraindicate the use of neurofeedback.","ALL","18 Years",{"count":20,"type":21},66,"ESTIMATED","INTERVENTIONAL",[24],"NA","Background:\n\nMigraine is a highly prevalent neurological disorder and one of the leading causes of disability worldwide, particularly among women of reproductive age. It is associated with substantial clinical, psychological, and socioeconomic burden, including increased risk of vascular and psychiatric comorbidities, reduced quality of life, sleep disturbances, and decreased productivity. Neurofeedback (NF) has emerged as a promising non-pharmacological intervention aimed at promoting self-regulation of brain activity through real-time feedback and neuroplasticity mechanisms.\n\nObjective:\n\nThis study aims to evaluate the effectiveness of neurofeedback as an adjunct therapy in reducing the frequency and severity of high-frequency episodic migraine in adults. Secondary objectives include assessing changes in medication use, sleep quality, disability and functional impact, depressive symptoms, and the influence of common migraine triggers.\n\nMethods:\n\nA randomized controlled trial with two parallel groups will be conducted at the University Hospital of Salamanca. Participants will be adults (\\>18 years) diagnosed with episodic migraine (5-14 days\u002Fmonth). A total of 66 participants will be randomly assigned (1:1) to either a neurofeedback intervention group or a control group. The intervention consists of 60 neurofeedback sessions over 12 weeks, including EEG-based training aimed at reducing high beta activity (21-30 Hz) and increasing alpha activity (8-12 Hz), as well as blood volume pulse biofeedback. The control group will receive no additional intervention. Primary outcomes include migraine frequency and severity, while secondary outcomes encompass medication use, disability (MIDAS, HIT-6), sleep quality (PSQI), quality of life (MSQ), depressive symptoms (PHQ-9), and trigger-related variables. Assessments will be performed at baseline, 3 months, and 6 months. Data will be analyzed using repeated-measures mixed models (SPSS v28).\n\nExpected Results:\n\nIt is hypothesized that neurofeedback will significantly reduce migraine frequency and severity compared to control conditions, and improve associated functional, psychological, and sleep-related outcomes.\n\nConclusions:\n\nThis trial aims to provide robust evidence on the efficacy of neurofeedback as a complementary therapeutic approach for migraine, addressing the current need for well-designed randomized controlled studies in this field.",[27],"Episodic Migraine",[29,30,31,32,33,34,35],"neurofeedback","episodic migraine","migraine frequency","migraine severity","sleep quality","disability","quality of life","NOT_YET_RECRUITING","2026-06-16",{"date":39,"type":40},"2026-06-22","ACTUAL",{"date":42,"type":21},"2026-11-15",{"date":44,"type":21},"2027-12-31",{"name":46,"class":47},"University of Salamanca","OTHER",1,{"id":50,"slug":51,"hasResults":12,"nctId":52,"briefTitle":53,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":55,"targetDuration":4,"studyType":22,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":71,"lastUpdatePostDateStruct":72,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":48},"100641133","impact-of-a-high-resolution-program-for-the-prevention-of-suicidal-behavior-in-at-risk-adults-a-quasi-experimental-ambispective-cohort-study-100641133","NCT07655986","Impact of a High-resolution Program for the Prevention of Suicidal Behavior in At-risk Adults: a Quasi-experimental Ambispective Cohort Study","Inclusion Criteria:\n\n* Patients ≥ 18 years of age.\n* No prior active follow-up by the mental health team.\n* Prior stabilization by the emergency psychiatry team.\n* Columbia Severity Rating Scale (C-SSRS) score corresponding to moderate-to-high risk.\n* Absence of criteria for urgent hospital admission.\n* Signed informed consent.\n\nExclusión Criteria:\n\n* Self-harm without suicidal intent.\n* Mild suicide risk (mild C-SSRS).\n* Extremely high suicide risk requiring urgent hospital admission.\n* Patient under active follow-up at another mental health unit.",{"count":56,"type":21},198,[24],"Background: Suicidal behavior represents a major public health problem worldwide. According to the World Health Organization (WHO), approximately 720.000 people die by suicide annually, and many more attempt it. Suicide is a personal tragedy associated with extreme suffering that has a serious impact on the deceased's immediate circle and on society as a whole. In this context, there is an urgent need to design effective and humane intervention strategies that offer an evidence-based, preventive, specialized, and community-oriented response to suicidal behavior.\n\nObjective: To evaluate the impact of a multidisciplinary, specialized, and high-resolution program for the prevention of suicidal behavior in adults aged 18 and over in the Salamanca Health Area.\n\nMethods: A quasi-experimental, ambispective cohort study with two parallel groups: an intervention group, receiving the specific suicide prevention program (SPP) with a pre-test\u002Fpost-test design, and a control group, receiving usual care (TC). Adult patients (≥ 18 years) will be referred from the Emergency Department of the University Hospital of Salamanca after an initial psychiatric evaluation. Patients will be assigned to the intervention group according to established inclusion criteria. The program lasts 3 months, during which each participant will receive intensive and individualized follow-up from a multidisciplinary team composed of two psychiatrists, two mental health nurses, two psychologists, and two social workers at two community mental health centers. Participants will also attend 10 weekly group therapy sessions. Follow-up evaluations will be conducted at the end of the program (three months) and six months after the first contact.\n\nDiscussion: This study will contribute to the scientific evidence base on the effectiveness of intensive and specific suicide prevention programs in the community setting, optimizing healthcare resources, improving treatment adherence, and aligning with the Spanish National Suicide Prevention Plan 2025-2027. Ethics and dissemination: This study has been approved by the Clinical Research Ethics Committee of the Salamanca Health Area (CEIm code: PI 2025 11 2102 - TD)\n\nKeywords: Suicidal behavior; Suicide prevention; Suicidal ideation; Community mental health services; Quasi-experimental study; Cohort study; Psychiatric emergency services; Patient care team.",[60],"Prevention of Suicidal Behavior",[62,63,64,65,66,67,68,69],"Suicidal behavior","Suicide prevention","Suicidal ideation","Community mental health services","Quasi-experimental study","Cohort study","Psychiatric emergency services","Patient care team","RECRUITING","2026-06-15",{"date":73,"type":40},"2026-06-18",{"date":75,"type":40},"2025-05-01",{"date":77,"type":21},"2027-05",{"name":46,"class":47},{"id":80,"slug":81,"hasResults":12,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":85,"eligibilityCriteria":86,"healthyVolunteers":87,"sex":88,"minAge":18,"maxAge":4,"enrollmentInfo":89,"targetDuration":4,"studyType":22,"phases":91,"briefSummary":92,"conditions":93,"keywords":100,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":107,"lastUpdatePostDateStruct":108,"startDateStruct":109,"completionDateStruct":111,"leadSponsor":113,"locationsCount":48},"100641377","polyphenol-intake-mediterranean-diet-adherence-and-oxidative-stress-in-pregnancy-100641377","NCT07656532","Polyphenol Intake, Mediterranean Diet Adherence, and Oxidative Stress in Pregnancy","Effect of Polyphenol Intake and Adherence to the Mediterranean Diet on Oxidative Stress During Pregnancy","PREGPOLY","Inclusion Criteria:\n\n* Pregnant women aged 18 years or older.\n* Singleton pregnancy.\n* Gestational age between 8 and 11 weeks at enrollment.\n* Receiving prenatal care within the Salamanca Health Area.\n* Able to understand the study information and provide written informed consent.\n* No clinical restrictions that would contraindicate dietary modifications.\n\nExclusion Criteria:\n\n* Medical or obstetric conditions that contraindicate dietary modifications.\n* Active metabolic, renal, or hepatic disease.\n* Severe hyperemesis gravidarum or gastrointestinal disorders limiting food intake.\n* Allergy or intolerance to cocoa.\n* Habitual high cocoa or chocolate consumption (\\>30 g\u002Fday).\n* Multiple pregnancy.\n* Severe obstetric complications diagnosed before enrollment.\n* Inability to comply with study procedures, attend follow-up visits, or communication barriers that could interfere with participation.",true,"FEMALE",{"count":90,"type":21},60,[24],"This study is a randomized controlled clinical trial designed to evaluate the effect of a polyphenol-rich dietary intervention during pregnancy on endothelial function, oxidative stress biomarkers, and maternal and neonatal outcomes.\n\nPregnancy is associated with metabolic and vascular adaptations, and complications such as gestational diabetes and hypertensive disorders are linked to endothelial dysfunction and increased oxidative stress. Dietary factors, particularly adherence to the Mediterranean diet and intake of polyphenol-rich foods, may play a protective role.\n\nPregnant women will be randomly assigned to either an intervention group or a control group. The intervention consists of daily consumption of 10 g of natural non-alkalized cocoa and structured dietary counseling aimed at achieving at least five daily servings of fruits and vegetables, alongside general Mediterranean diet recommendations.\n\nThe intervention will last 12 weeks, from early to mid-pregnancy. Biomarkers of endothelial function and oxidative stress will be measured at different time points, along with clinical maternal outcomes (including gestational diabetes and hypertensive disorders) and neonatal outcomes.\n\nThe aim is to determine whether this dietary intervention improves endothelial function, reduces oxidative stress, and contributes to better pregnancy outcomes.",[94,95,96,97,98,99],"Pregnancy","Gestational Diabetes Mellitus (GDM)","Preeclampsia","Hypertension, Pregnancy-Induced","Oxidative Stress","Endothelial Dysfunction",[101,102,103,104,105,106],"Mediterranean diet","Polyphenols","Cocoa supplementation","Oxidative stress","Endothelial function","Randomized controlled trial","2026-06-14",{"date":73,"type":40},{"date":110,"type":21},"2026-09-01",{"date":112,"type":21},"2028-10-01",{"name":46,"class":47},{"id":115,"slug":116,"hasResults":12,"nctId":117,"briefTitle":118,"officialTitle":119,"acronym":4,"eligibilityCriteria":120,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":18,"enrollmentInfo":121,"targetDuration":4,"studyType":22,"phases":123,"briefSummary":124,"conditions":125,"keywords":128,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":4},"100643554","effects-of-a-therapeutic-strength-training-programme-in-paediatric-cancer-patients-100643554","NCT07638163","EFFECTS OF A THERAPEUTIC STRENGTH TRAINING PROGRAMME IN PAEDIATRIC CANCER PATIENTS","EFFECTS OF A THERAPEUTIC STRENGTH TRAINING PROGRAMME ON QUALITY OF LIFE, FUNCTIONAL ABILITY AND MENTAL HEALTH IN PAEDIATRIC CANCER PATIENTS","Inclusion Criteria:\n\n* People under the age of 18 who have been diagnosed with cancer and are currently undergoing treatment or living with the after-effects of the disease.\n* People who have not engaged in regular physical activity in the last 8 weeks.\n* Performance Status (ECOG) 0-1.\n* Signing of the informed consent form.\n\nExclusion Criteria:\n\n* Have any contraindications to physical exercise: severe musculoskeletal disorders, severe cardiovascular diseases, uncontrolled bone metastases, and other conditions as determined by a healthcare professional.\n* Patients who are unable to undergo the initial assessment tests or who have difficulty performing basic exercises.\n* Patients who must discontinue treatment due to intolerance to it.\n* Other circumstances, at the discretion of the investigators, that may interfere with the purpose or conduct of the study.",{"count":122,"type":21},20,[24],"This project is made possible through the Pediatrics Department of the University Hospital of Salamanca, in collaboration with researchers specialized in therapeutic exercise from other clinical trials and research projects, alongside physical therapists experienced in designing, programming, and supervising therapeutic exercise programs.\n\nFurthermore, the project addresses current healthcare needs, as a significant portion of the patient population exhibits symptoms that impair functional capacity and overall quality of life-driven both by age and the oncological disease and its treatment. Consequently, this initiative aims to implement a strength training program to foster beneficial outcomes across various aspects of these patients' health, while sharing the findings with the scientific community.",[126,127],"Cancer","Paediatric",[126,129,127],"Exercise","2026-06-04",{"date":132,"type":40},"2026-06-10",{"date":134,"type":21},"2026-05-30",{"date":136,"type":21},"2026-12-30",{"name":46,"class":47},{"id":139,"slug":140,"hasResults":12,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":146,"targetDuration":4,"studyType":22,"phases":148,"briefSummary":149,"conditions":150,"keywords":152,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":160,"lastUpdatePostDateStruct":161,"startDateStruct":163,"completionDateStruct":165,"leadSponsor":167,"locationsCount":4},"100622757","muscle-deterioration-in-hospitalized-cancer-patient-100622757","NCT07387770","Muscle Deterioration in Hospitalized Cancer Patient","Assessment of Muscle Deterioration in Hospitalized Cancer Patients Using Surface Electromyography, Dynamometry, and Bioimpedance","MUSONC","Inclusion Criteria:\n\n* Age: more than 18 years\n* Confirmed malignant neoplasm diagnosis\n* Hospitalization anticipated for at least 4 days\n* Capacity to provide informed consent and complete questionnaires\n* ECOG performance status 0-3\n* Ability to perform voluntary contractions of upper and lower extremities\n\nExclusion Criteria:\n\n* Medical contraindications to strength testing (recent fractures, acute injuries) - Severe neurological impairment precluding functional assessment\n* Implanted electronic devices (relative contraindication for bioimpedance)\n* Severe cognitive impairment preventing questionnaire completion\n* Extensive skin lesions preventing electrode placement for sEMG",{"count":147,"type":21},40,[24],"Cancer cachexia and skeletal muscle deterioration represent significant challenges in oncology, affecting up to 42% of cancer patients and correlating with poor clinical outcomes, increased treatment toxicity, and reduced overall survival. Early identification of patients at risk through comprehensive musculoskeletal assessment is essential for timely therapeutic intervention.\n\nThis paper presents a detailed protocol for the longitudinal evaluation of skeletal muscle deterioration in hospitalized cancer patients using an integrated, multimodal approach. The protocol combines validated questionnaires (SARC-F, MSAS, EORTC QLQ-C30, and PSQI), functional measurements (handgrip strength), body composition analysis (bioelectrical impedance analysis), neuromuscular assessment (surface electromyography), and serum biomarkers (basic panel approach).\n\nThe study aims to recruit 45-50 patients with confirmed malignancy requiring hospitalization for ≥4 days, with daily functional measurements and biomarker evaluations at admission and discharge. The protocol prioritizes methodological rigor in vulnerable populations, incorporates standardized procedures for real-world clinical settings, and emphasizes quality control measures.\n\nExpected outcomes include the identification of longitudinal patterns of muscle deterioration, validation of serum biomarker signatures for cachexia detection, and characterization of neuromuscular fatigue patterns using surface electromyography. This comprehensive framework addresses current gaps in skeletal muscle assessment during acute hospitalization and provides a foundation for future interventional studies. The protocol adheres to international ethical standards and considerations for research in vulnerable populations.",[151],"Oncologic Diseases",[153,154,155,156,157,158,159],"cancer cachexia","sarcopenia","surface electromyography","bioimpedance analysis","hospitalized patients","protocol","muscle deterioration","2026-05-18",{"date":162,"type":40},"2026-05-19",{"date":164,"type":21},"2026-07-01",{"date":166,"type":21},"2026-12-31",{"name":46,"class":47},{"id":169,"slug":170,"hasResults":12,"nctId":171,"briefTitle":172,"officialTitle":173,"acronym":4,"eligibilityCriteria":174,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":175,"enrollmentInfo":176,"targetDuration":4,"studyType":22,"phases":178,"briefSummary":179,"conditions":180,"keywords":186,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":192,"lastUpdatePostDateStruct":193,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":48},"100640667","effectiveness-of-dance-therapy-in-stroke-patients-100640667","NCT07578493","Effectiveness of Dance Therapy in Stroke Patients.","Effectiveness of Proprioceptive Neuromuscular Facilitation-based Dance Therapy for Patients With Chronic Stroke.","Inclusion Criteria:\n\n* Chronic hemiparesis (≥ 6 months post-stroke).\n* Ability to maintain independent standing or with minimal assistance.\n* Clinical stability to perform moderate physical exercise.\n* Sufficient understanding to follow simple instructions.\n\nExclusion Criteria:\n\n* Severe aphasia or other cognitive disorders that limit comprehension.\n* Behavioral disorders that hinder group participation.\n* Severe musculoskeletal disorders or concomitant neurological conditions.","80 Years",{"count":177,"type":21},16,[24],"Hemiparesis following a stroke is associated with persistent deficits in postural control, balance, and social participation, especially in the chronic phase. Dance therapy, as a multisensory intervention based on movement, music, and body expression, could promote sensorimotor integration and improve postural stability, complementing conventional physiotherapy. The primary objective of this pilot study is to evaluate the effect of a therapeutic dance program on postural control in individuals with chronic hemiparesis. A secondary objective is to analyze changes in functional balance and gait, as well as subjective satisfaction with the therapy. A controlled study with two parallel groups will be conducted. Sixteen participants with chronic hemiparesis will be recruited (n=8 experimental group; n=8 control group). Both groups will receive standard physiotherapy, but the experimental group will also receive an 8-week therapeutic dance program, with one 30-minute session per week to complement their usual therapy. Pre- and post-intervention assessments will be performed. ThThe experimental group is expected to show a significantly greater improvement in posturographic and clinical parameters compared to the control group. The results could support the implementation of dance therapy as a complementary intervention in community neurorehabilitation programs.",[181,182,183,184,185],"Balance","Gait Analysis","Thermography","Range of Motion, Articular","Muscular Strength",[187,188,189,190,191],"Dance Therapy","Stroke","Postural balance","Gait","Physical Therapy Modalities","2026-05-05",{"date":194,"type":40},"2026-05-11",{"date":196,"type":21},"2026-05-15",{"date":198,"type":21},"2026-11-30",{"name":46,"class":47},{"id":201,"slug":202,"hasResults":12,"nctId":203,"briefTitle":204,"officialTitle":205,"acronym":206,"eligibilityCriteria":207,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":208,"targetDuration":4,"studyType":22,"phases":210,"briefSummary":211,"conditions":212,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":217,"startDateStruct":219,"completionDateStruct":220,"leadSponsor":221,"locationsCount":48},"100618603","equisock-new-antiequine-100618603","NCT07333768","EQUISOCK: New Antiequine","EQUISOCK: New Antiequine for Ankle","EQUISOCK","Inclusion Criteria:\n\n* patients with chronic ankle injuries\n* patients with external popliteal sciatic nerve lesion or nerve injuries resulting in loss of ankle dorsiflexion\n* patients who have already been prescribed an orthosis\n* patients of all ages\n\nExclusion Criteria:\n\n* inability to stand actively and stably\n* inability to walk unaided\n* inability to follow instructions",{"count":209,"type":21},4,[24],"The goal of this experimental study is to test the feasibility and validity of a new orthosis in patients with ankle lesions (external popliteal sciatic nerve or nerve injuries resulting in loss of ankle dorsiflexion) of both sexes and all ages. The main question it aims to answer is:Is the new orthosis a support for ankle stability??Does the new orthosis improve ankle function and patients' quality of life??The control group will be the subjects themselves when wearing their conventional ankle orthosis or without it. Participants must wear the new ankle orthosis for at least one month to assess the effectiveness of the orthosis and evaluate any changes that have occurred in the ankle joint and muscles.",[213,214,215],"Ankle (Ligaments); Instability (Old Injury)","Ankle Equinus","Ankle Dorsiflexion","2026-04-27",{"date":218,"type":40},"2026-04-28",{"date":164,"type":21},{"date":166,"type":21},{"name":46,"class":47},{"id":223,"slug":224,"hasResults":12,"nctId":225,"briefTitle":226,"officialTitle":227,"acronym":228,"eligibilityCriteria":229,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":230,"targetDuration":4,"studyType":22,"phases":231,"briefSummary":232,"conditions":233,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":236,"startDateStruct":237,"completionDateStruct":238,"leadSponsor":239,"locationsCount":48},"100618614","orlint--orlext-orthosis-for-knee-100618614","NCT07333911","ORLINT & ORLEXT: Orthosis for Knee","ORLINT & ORLEXT: New Orthosis for the Lateral Knee Ligaments","ORLINT&ORLEXT","Inclusion Criteria:\n\n* patients with chronic knee injuries\n* patients who have already been prescribed an orthosis\n* patients older than 18 years old\n\nExclusion Criteria:\n\n* inability to stand actively and stably\n* inability to walk unaided",{"count":209,"type":21},[24],"The goal of this experimental study is to test the feasibility and validity of a new orthosis in patients with lateral ligament knee lesions of both sexes and older than 18 years old. The main question it aims to answer is:\n\nIs the new orthosis a support for knee stability?? Does the new orthosis improve knee function and patients' quality of life??\n\nThe control group will be the subjects themselves when wearing their conventional knee orthosis or without it.\n\nParticipants must wear the new knee orthosis for at least one month to assess the effectiveness of the orthosis and evaluate any changes that have occurred in the knee joint and muscles.",[234,235],"Knee Brace","Knee",{"date":218,"type":40},{"date":164,"type":21},{"date":166,"type":21},{"name":46,"class":47},{"id":241,"slug":242,"hasResults":12,"nctId":243,"briefTitle":244,"officialTitle":244,"acronym":4,"eligibilityCriteria":245,"healthyVolunteers":12,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":246,"targetDuration":4,"studyType":22,"phases":248,"briefSummary":249,"conditions":250,"keywords":253,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":216,"lastUpdatePostDateStruct":255,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":259,"locationsCount":260},"100605699","effects-of-a-group-versus-individual-cognitive-training-program-on-chemotherapy-induced-cognitive-impairment-chemobrain-in-breast-cancer-patients-undergoing-active-treatment-100605699","NCT07165912","Effects of a Group Versus Individual Cognitive Training Program on Chemotherapy-induced Cognitive Impairment (Chemobrain) in Breast Cancer Patients Undergoing Active Treatment","Inclusion Criteria:\n\nBeing an adult (18 years or older). Having a recent histopathological diagnosis of newly diagnosed breast cancer and starting oncological treatment.\n\nBeing fully capable of performing daily functions. Willingness to voluntarily participate in the study and signing the informed consent.\n\nExclusion Criteria:\n\nLack of literacy skills or significant language comprehension deficit. Diagnosis of a Central Nervous System tumor or participation in another cognitive stimulation program.\n\nClinical diagnosis of a neurocognitive disorder as defined in the DSM-V.\n\nWithdrawal Criteria:\n\nDropping out of the program or not completing the final evaluation",{"count":247,"type":21},75,[24],"Introduction: The significant improvement in breast cancer survival, largely attributable to biomedical and technological progress, makes it increasingly necessary to investigate the secondary effects linked to this pathology. Among these, cancer-related cognitive impairment (CRCI) stands out as one of the most frequent yet frequently overlooked complications.\n\nObjective: To evaluate the impact of a structured cognitive training program on the management of CRCI in patients with breast cancer receiving active treatment.\n\nMethodology: A randomized controlled clinical trial will be conducted with two arms: an Intervention Group (IG) and a Control Group (CG). The study will include patients with a recent diagnosis of breast cancer. Based on sample size calculations, 50 participants will be recruited-25 per group-to detect a minimum difference of 2.95 points on the MoCA (Montreal Cognitive Assessment), a tool commonly used to assess cognitive performance. All participants will receive an informational leaflet aligned with the latest WHO recommendations for preventing cognitive decline. In addition, the IG will complete an individualized cognitive training (CT) program focused on everyday cognitive skills (EC). The program will provide a dossier with 80 training sessions, structured into four phases (P1-P4) of 20 activities each, to be implemented monthly. Baseline assessments and a follow-up four months after the intervention will be carried out in both groups. Variables collected will include sociodemographic and clinical data, as well as outcome measures for cognitive status (MoCA), everyday cognition (PECC), anxiety levels (Hamilton scale), functional capacity (LB), sleep quality (PSQI), quality of life (ECOG), and subjective memory complaints (FACT-COG).\n\nImpact: Findings from this study could support the development of targeted cognitive rehabilitation strategies and the implementation of clinical protocols for individuals undergoing breast cancer treatment. By addressing CRCI-an underrecognized but increasingly prevalent issue given rising survival rates-these interventions may contribute to improving patients' overall quality of life.",[251,252],"Breast Cancer Females","Oncology",[254,126],"Cognitive training",{"date":218,"type":40},{"date":257,"type":21},"2026-05-01",{"date":166,"type":21},{"name":46,"class":47},2,{"id":262,"slug":263,"hasResults":12,"nctId":264,"briefTitle":265,"officialTitle":265,"acronym":266,"eligibilityCriteria":267,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":175,"enrollmentInfo":268,"targetDuration":4,"studyType":22,"phases":270,"briefSummary":271,"conditions":272,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":276,"lastUpdatePostDateStruct":277,"startDateStruct":279,"completionDateStruct":281,"leadSponsor":283,"locationsCount":48},"100602772","effects-of-treadmill-based-gait-training-in-patients-with-stroke-100602772","NCT07127861","Effects of Treadmill-Based Gait Training in Patients With Stroke","TreadmillACV","Inclusion Criteria:\n\n* Aged between 18 and 80 years\n* History of stroke at least six months prior\n* Presence of hemiplegia or hemiparesis\n* Ability to walk independently or with assistive devices\n\nExclusion Criteria:\n\n* Cognitive impairments interfering with the understanding of treatment procedures\n* Inability to get on and maintain position on the treadmill\n* Severe heart failure\n* Active inflammatory or infectious conditions at the time of evaluation\n* Attendance below 80% of scheduled sessions",{"count":269,"type":21},24,[24],"Hemiplegia is one of the most common sequelae after stroke. Most patients develop thermal asymmetry between the affected and contralateral sides of the body, as well as an asymmetric gait pattern characterized by differences in the duration of gait cycle phases, step length, cadence, and weight distribution between limbs. These patterns result in reduced aerobic capacity, endurance, energy efficiency, and walking speed, negatively impacting the patient's functional abilities.\n\nThere are different methodologies for the treatment gait impairments. Among them, treadmill training has been investigated as an effective therapeutic approach to post-stroke rehabilitation.\n\nTreadmill gait training may reduce asymmetry between hemibodies in hemiplegic patients.\n\nFor this reason, our aim is to describe the effects of treadmill training on gait, focusing on its impact on thermal asymmetry, walking speed, aerobic endurance, and the biomechanical and kinematic characteristics of gait.\n\nPatients with hemiplegia will undergo treadmill-based gait training to evaluate its influence on the recovery of this sequel of stroke.",[190,183,273,274,275,182],"Walking Speed, Mesh id D000072797","Endurance","Step Time and Length","2026-03-25",{"date":278,"type":40},"2026-03-31",{"date":280,"type":40},"2025-09-14",{"date":282,"type":21},"2026-03",{"name":46,"class":47},{"id":285,"slug":286,"hasResults":12,"nctId":287,"briefTitle":288,"officialTitle":289,"acronym":290,"eligibilityCriteria":291,"healthyVolunteers":87,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":292,"targetDuration":4,"studyType":22,"phases":294,"briefSummary":295,"conditions":296,"keywords":300,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":305,"lastUpdatePostDateStruct":306,"startDateStruct":308,"completionDateStruct":310,"leadSponsor":312,"locationsCount":4},"100630168","reducing-ageism-in-organizations-a-study-protocol-100630168","NCT07484165","Reducing Ageism in Organizations: A Study Protocol","Reducing Ageism in the Workplace: Protocol for a Psychoeducational Programme in a Randomised Controlled Trial","ageism","Inclusion Criteria:\n\n* Currently employed with at least five years of tenure in the organization or the relevant sector. At this stage of their career, attitudes toward colleagues from different generations are considered more likely to be deeply ingrained, making this profile particularly suitable for the intervention.\n* Performing tasks that involve frequent collaboration with colleagues from different generations.\n* Ability and willingness to attend the program sessions regularly.\n\nExclusion Criteria:\n\nWorkers who meet any of the following conditions will be excluded from the study:\n\n* Significant reading or linguistic comprehension difficulties that prevent them from participating adequately in psychoeducational sessions or completing assessment instruments.\n* Serious and destabilised medical or psychological disorders that may interfere with the normal development of the programme (e.g., severe untreated depressive episodes, limiting neurological disorders).\n* Failure to meet the inclusion criteria, specifically not having been with the company for at least five years or not participating in intergenerational teams.\n* Refusal to sign the informed consent form or lack of availability to attend programme sessions regularly.",{"count":293,"type":21},90,[24],"Background: This article presents the protocol for a randomised controlled trial designed to develop and evaluate a psychoeducational intervention aimed at reduce ageism in the workplace, will improve attitudes toward older workers as well as various indicators of well-being and psychosocial functioning in the professional context.\n\nMethods: The study will be conducted at the Faculty of Psychology of the University of Salamanca (Spain). Currently employed with at least five years of tenure in the organization or the relevant sector, performing tasks that involve frequent collaboration with colleagues from different generations will be recruited. Participants will be randomly assigned to two groups: the intervention group, which will undergo a psychoeducational programme consisting of 12 sessions over 3 months; and the control group, which will receive a educational programme of one session. All participants will complete initial and final assessments, as well as a 3-month follow-up, collecting sociodemographic data and applying various psychological, social and health assessment instruments.\n\nDiscussion: This protocol describes a comprehensive psychoeducational intervention aimed at reducing negative stereotypical beliefs about older workers and enhance relevant psychosocial variables in the organizational environment, such as job satisfaction, psychological flexibility, perceived social support, perceived health, and self-efficacy in navigating intergenerational work situations. The evidence generated will guide future interventions, policies, and educational programmes to promote preparing workers and teams in several key areas, such as recognising and challenging age-related stereotypes, developing empathy towards colleagues from different generations, promoting inclusive practices in daily interaction and work collaboration and fostering a more equitable and respectful organisational climate towards all ages.",[297,298,299],"Ageism","Job Satisfaction","Workers",[290,301,302,303,304],"organizations","job satisfaction","psychoeducational intervention","psychology","2026-03-16",{"date":307,"type":40},"2026-03-19",{"date":309,"type":21},"2026-09",{"date":311,"type":21},"2027-12",{"name":46,"class":47},{"id":314,"slug":315,"hasResults":12,"nctId":316,"briefTitle":317,"officialTitle":318,"acronym":4,"eligibilityCriteria":319,"healthyVolunteers":12,"sex":17,"minAge":320,"maxAge":4,"enrollmentInfo":321,"targetDuration":4,"studyType":22,"phases":323,"briefSummary":324,"conditions":325,"keywords":328,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":48},"100627341","exercise-during-hemodialysis-impact-on-sarcopenia-and-sleep-quality-100627341","NCT07447375","Exercise During Hemodialysis: Impact on Sarcopenia and Sleep Quality","Intrahospital Exercise Program in Hemodialysis Patients: Impact on Sarcopenia Markers, Sleep Quality, and Quality of Life.","Inclusion Criteria:\n\n* Subjects currently enrolled in a Chronic Hemodialysis Unit.\n* Patients who have been on hemodialysis treatment for more than 3 months.\n* Subjects aged 40 years or older.\n* Hemoglobin levels greater than 10 mg\u002Fdl.\n* Ability to perform physical fitness assessment tests or dynamometry.\n* Willingness and ability to provide signed informed consent\n\nExclusion Criteria:\n\n* Presence of intradialytic instability.\n* Medical conditions where exercise is contraindicated: active infectious process, neoplasms, uncontrolled arrhythmias, or left ventricular dysfunction (EF \\\u003C 35%).\n* Musculoskeletal or respiratory alterations that worsen with exercise.\n* Lower limb amputation without a prosthesis.\n* Cerebrovascular disease (stroke with sequelae or transient ischemic attacks within the previous 6 weeks).\n* Uncontrolled hypertension (Systolic BP \\> 200 mmHg or Diastolic BP \\> 120 mmHg).\n* Unstable angina (at rest or during exercise) or history of coronary bypass\u002Fischemic heart disease within the previous 6 weeks.\n* Diabetes mellitus with severe decompensation (blood glucose \\> 300 mg\u002Fdl).\n* Dialysis-related hypotension (mean blood pressure \\\u003C 90\u002F70 mmHg).\n* Psychiatric or cognitive alterations that prevent collaboration with muscle training programs.\n* Presence of an arteriovenous fistula in a lower limb.\n* Motor neurological injury causing dysfunction that prevents the application of the strength protocol.\n* Hospitalization within the 3 months prior to the study.\n* Lack of cooperation (defined as failing to attend more than 25% of sessions) or inability to understand the treatment.","40 Years",{"count":322,"type":21},58,[24],"Sarcopenia (the loss of muscle mass, strength, and function) is highly prevalent in patients with Chronic Kidney Disease (CKD) undergoing hemodialysis, significantly increasing the risk of falls, frailty, and mortality. Despite its impact, there is a lack of evidence regarding the effectiveness of exercise programs specifically designed to address sarcopenia under the latest international diagnostic criteria (EWGSOP2) in older renal patients.\n\nThe primary objective of this randomized controlled clinical trial is to evaluate the effects of a 12-week supervised intrahospital exercise program on muscle mass, strength, and physical performance in hemodialysis patients over 40 years of age. Additionally, the study aims to analyze how this intervention influences sleep quality-often disrupted in this population-and overall health-related quality of life.\n\nParticipants will be randomly assigned to either an Intervention Group, which will perform personalized strength and aerobic exercises during the first 90 minutes of their dialysis sessions, or a Control Group, receiving standard care. Evaluations will be conducted at three points: baseline (pre-randomization), at 12 weeks (post-intervention).\n\nThe investigators hypothesize that integrating physical exercise into the routine clinical care of hemodialysis patients will improve sarcopenia markers and sleep patterns, leading to greater functional independence and better clinical outcomes.",[326,327],"Sarcopenia","Renal Insufficiency, Chronic",[329,330,331,332],"Hemodialysis","Intradialytic Exercise","Sleep Quality","Quality of Life","2026-02-27",{"date":335,"type":40},"2026-03-03",{"date":337,"type":40},"2026-01-02",{"date":339,"type":21},"2027-06-30",{"name":46,"class":47},{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":346,"acronym":347,"eligibilityCriteria":348,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":351,"phases":4,"briefSummary":352,"conditions":353,"keywords":356,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":363,"lastUpdatePostDateStruct":364,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":48},"100626401","acures-acoustic-and-respiratory-parameters-for-dysarthria-assessment-100626401","NCT07435155","ACURES: Acoustic and Respiratory Parameters for Dysarthria Assessment","Evaluating Dysarthria Through Acoustic and Respiratory Parameters: A Clinical Protocol","ACURES","Inclusion Criteria:\n\n* Adults aged 18 years or older at the time of enrollment.\n\nDiagnosed with acquired brain injury (ABI), including:\n\n* Stroke\n* Traumatic brain injury (TBI)\n* Brain tumor\n* Ability to provide written informed consent (or via a legally authorized representative if necessary).\n* Cognitive function preserved, defined as a Mini-Mental State Examination (MMSE) score ≥ 24.\n\nExclusion Criteria:\n\n* History of chronic respiratory diseases, such as chronic obstructive pulmonary disease (COPD) or asthma.\n* History of hearing impairments that could affect speech evaluation.\n* Presence of additional neurological or neurodegenerative disorders other than the acquired brain injury.\n* History of voice disorders or dysphonia prior to the acquired brain injury.\n* Presence of persistent pharyngeal symptoms, such as mucus, secretions, or foreign body sensation, which may interfere with speech assessment.\n* Participants unable to comply with the assessment protocol or complete the required sessions.\n* Presence of apahasia that prevents participation in speech tasks, such as reading, repetition, or spontaneous speech priduction.",{"count":350,"type":21},100,"OBSERVATIONAL","The goal of this observational study is to describe speech and breathing patterns in adults after acquired brain injury (ABI) and understand how these patterns relate to the presence, severity, and type of dysarthria. The main questions it aims to answer are:\n\n* What changes in voice and breathing are observed in adults with dysarthria after ABI?\n* Can combining acoustic, respiratory, and clinical assessments help identify dysarthria severity and subtype?\n\nParticipants will:\n\n* Have their speech recorded to measure voice and articulation features, such as pitch, clarity, and the ability to sustain sounds.\n* Perform breathing tests using a spirometer to assess lung function.\n* Complete the Frenchay Dysarthria Assessment-2 (FDA-2), adapted to Spanish, to classify dysarthria type and severity.\n\nAbout 97 to 101 participants will take part. The results will help speech therapists better detect, evaluate, and treat dysarthria in adults after brain injury.",[354,355],"Dysarthria","Acquired Brain Injury",[357,358,359,360,361,362],"acquired brain injury","dysarthria","Spirometry","Speech therapy","voice disorders","Phono-respiratory assessment","2026-02-19",{"date":333,"type":40},{"date":366,"type":40},"2025-10-15",{"date":368,"type":21},"2026-10-15",{"name":46,"class":47},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":375,"acronym":4,"eligibilityCriteria":376,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":377,"enrollmentInfo":378,"targetDuration":4,"studyType":22,"phases":380,"briefSummary":381,"conditions":382,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":386,"lastUpdatePostDateStruct":387,"startDateStruct":389,"completionDateStruct":391,"leadSponsor":393,"locationsCount":48},"100610932","neurofeedback-mindfulness-techniques-on-anxiety-stress-and-academic-performance-of-nursing-students-100610932","NCT07234006","Neurofeedback-mindfulness Techniques on Anxiety, Stress, and Academic Performance of Nursing Students","EFFECT OF NEUROFEEDBACK-MINDFULNESS TECHNIQUES ON ANXIETY, STRESS, AND ACADEMIC PERFORMANCE OF NURSING STUDENTS","Inclusion Criteria:\n\n* Students enrolled in the nursing degree at the University of Salamanca\n* Aged between 18 and 45 years\n* Willing to voluntarily participate in the study and sign the informed consent form.\n\nExclusion Criteria:\n\n* History of serious psychiatric disorders in the 6 months prior to inclusion in the study.","45 Years",{"count":379,"type":21},36,[24],"In today's society, anxiety and stress are prevalent emotional responses in mental health globally, significantly affecting students' well-being and academic performance. In particular, undergraduate nursing students face high levels of these problems due to the heavy academic workload and demands of their training, especially during exam periods. The need for concentration, emotional management, and decision-making under pressure contribute to the prevalence of these disorders, impacting both their quality of life and academic performance.\n\nDespite the existence of multiple strategies and techniques for managing these issues, it is still necessary to continue exploring innovative alternatives that complement traditional interventions. For this reason, this project aims to evaluate the effectiveness of mindfulness-neurofeedback as a treatment to reduce stress and anxiety in nursing students, with the goal of providing scientific evidence on this intervention. This brain training technique is presented as a promising option, based on the modulation of brain activity, with the potential to improve emotional regulation and concentration in the educational setting.",[383,384,385],"Anxiety","Stress","Academic Performance","2026-02-06",{"date":388,"type":40},"2026-02-09",{"date":390,"type":40},"2025-11-21",{"date":392,"type":21},"2026-05-31",{"name":46,"class":47},{"id":395,"slug":396,"hasResults":12,"nctId":397,"briefTitle":398,"officialTitle":399,"acronym":4,"eligibilityCriteria":400,"healthyVolunteers":87,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":401,"targetDuration":4,"studyType":22,"phases":403,"briefSummary":404,"conditions":405,"keywords":408,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":413,"lastUpdatePostDateStruct":414,"startDateStruct":416,"completionDateStruct":417,"leadSponsor":418,"locationsCount":48},"100622789","benefits-of-strength-training-in-informal-caregivers-of-patients-with-alzheimers-disease-100622789","NCT07388186","Benefits of Strength Training in Informal Caregivers of Patients With Alzheimer's Disease","Effectiveness of a Combined Strength Training and Progressive Muscle Relaxation Program in Reducing Frailty in Informal Caregivers of People With Alzheimer's Disease: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 years or older\n* Informal caregivers of a person with Alzheimer's disease\n* Providing regular care for at least 10 hours per week\n* Ability to attend intervention sessions\n* Ability to understand and follow instructions\n* Provision of written informed consent\n\nExclusion Criteria:\n\n* Acute illness or medical conditions contraindicating participation in strength exercise\n* Participation in structured exercise programs that may interfere with study outcomes\n* Severe or uncontrolled psychiatric disorders\n* Physical limitations preventing completion of functional assessments",{"count":402,"type":21},62,[24],"Informal caregivers of people with Alzheimer's disease experience high physical and psychological burden, increasing their risk of frailty, anxiety, and caregiver burnout. This randomized controlled trial aims to evaluate the effectiveness of a combined strength training and progressive muscle relaxation program compared with progressive muscle relaxation alone. The intervention will last 10 weeks, with assessments conducted at baseline, post-intervention, and at a 3-month follow-up. Primary outcomes include frailty, anxiety, and caregiver burden.",[406,407,383],"Frailty","Caregiver Burden",[406,409,410,383,411,412],"Strength","Caregiver","Burden","Alzheimer disease","2026-01-30",{"date":415,"type":40},"2026-02-04",{"date":282,"type":21},{"date":309,"type":21},{"name":46,"class":47},{"id":420,"slug":421,"hasResults":12,"nctId":422,"briefTitle":423,"officialTitle":424,"acronym":4,"eligibilityCriteria":425,"healthyVolunteers":87,"sex":88,"minAge":426,"maxAge":4,"enrollmentInfo":427,"targetDuration":4,"studyType":22,"phases":428,"briefSummary":429,"conditions":430,"keywords":431,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":435,"lastUpdatePostDateStruct":436,"startDateStruct":438,"completionDateStruct":439,"leadSponsor":441,"locationsCount":48},"100620582","multicomponent-training-and-muscle-quality-in-older-women-100620582","NCT07359495","Multicomponent Training and Muscle Quality in Older Women","Effect of a Multicomponent Exercise Program on Muscle Quality Assessed by Ultrasound, Body Composition, and Functionality in Older Women: A Randomized Controlled Trial Protocol","Inclusion Criteria:\n\n* Being a woman over 60 years of age, residing in the community, and enrolled in the GPR\n\nExclusion Criteria:\n\n* Having neuromuscular diseases, recent abdominal surgery, metal implants incompatible with measurements, unstable cardiovascular diseases, or previous participation in another exercise program.","60 Years",{"count":147,"type":21},[24],"This study aims to evlauate the effect os a 32-week multicomponent training (MT) program on muscle architecture and muscle quality (assessed by ultrasound) in womer over 60 years. The study will also analyze concurrent changes in muscle strength, physical performance, and body composition. The hypothesis is that the training will induce positive architectural adaptations, such as reduced echogenicity and increased thickness in the rectus femoris and rectus abdominis muscles, correlating with improved functional independence.",[326],[432,433,434,326],"Healthy aging","Muscle Quality","Physical Function","2026-01-13",{"date":437,"type":40},"2026-01-22",{"date":110,"type":21},{"date":440,"type":21},"2027-06-15",{"name":46,"class":47},{"id":443,"slug":444,"hasResults":12,"nctId":445,"briefTitle":446,"officialTitle":446,"acronym":447,"eligibilityCriteria":448,"healthyVolunteers":12,"sex":17,"minAge":449,"maxAge":4,"enrollmentInfo":450,"targetDuration":4,"studyType":22,"phases":451,"briefSummary":452,"conditions":453,"keywords":455,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":461,"lastUpdatePostDateStruct":462,"startDateStruct":464,"completionDateStruct":466,"leadSponsor":468,"locationsCount":48},"100615046","efficacy-of-pain-science-education-combined-with-exercise-in-older-adults-with-chronic-pain-100615046","NCT07287501","Efficacy of Pain Science Education Combined With Exercise in Older Adults With Chronic Pain","PSE-EX-OA","Inclusion Criteria:\n\n* Adults over 65 years of age\n* History of pain lasting more than 3 months.\n* Pain intensity of at least 3 out of 10 on the numeric pain rating scale.\n* Ability to understand, speak, and write in Spanish.\n\nExclusion Criteria:\n\n* Severe cognitive impairment (score \\\u003C 24 on the Mini-Mental State Exam).\n* Psychiatric disorders.\n* Uncontrolled systemic or inflammatory conditions.\n* Uncontrolled cardiac conditions.\n* Any other circumstances deemed by the investigators that could interfere with the study's purpose or conduct.\n\nElimination Criteria:\n\n\\- Attendance below 85% of total sessions.","65 Years",{"count":350,"type":21},[24],"As people live longer, long-term pain becomes more common in old age. This type of pain can greatly affect quality of life, reduce independence in daily activities, and diminish overall well-being.\n\nThis study is part of a project called PReGe, which aims to help older adults age actively and healthily through preventive physiotherapy. The goal is to determine whether a combination of adapted exercise and education about how pain works can help improve the lives of those who suffer from it.\n\nThe study is supported by the City Council of Salamanca and the Faculty of Nursing and Physiotherapy, and it is carried out in collaboration with the Doctoral Program in Health, Disability, Dependency, and Well-being at the University of Salamanca.\n\nThe purpose of this study is to determine whether a program that combines physical exercise with educational sessions about pain is more effective for adults over 65 years of age with chronic pain, compared to doing exercise alone. The study aims to find out whether this program improves pain, understanding of pain, mobility, quality of life and Quantitative Electroencephalography (qEEG).\n\nThis is a medical research study involving participants aged 65 years or older who have experienced pain for more than three months, with an intensity of at least 3 on a 0-to-10 scale. Participants will be randomly assigned to one of three groups, each following a different type of program:\n\nGroup 1 (Control Group): will perform only adapted physical exercise. Group 2: will perform the same physical exercise and attend educational sessions about pain for 8 weeks.\n\nGroup 3: will also perform the physical exercise and attend the educational sessions, but for a period of 32 weeks.\n\nThe study will last for one full year. The exercise program will be supervised by physiotherapists, carried out over 32 weeks, three times per week, with each session lasting approximately 50 minutes. The educational sessions on pain will be brief-about 15 minutes each-and will take place immediately before the exercise sessions.\n\nDuring the first two months, there will be two educational talks per week. After the Christmas break, Group 3 will continue with one talk every two weeks until the end of the study.\n\nThree evaluations will be conducted: one before starting the program, another at two months (questionnaires and qEEG only), and a final one at nine months. The initial and final evaluation sessions will last approximately 75 minutes per participant, while the intermediate evaluation of the questionnaires will take about 45 minutes per person.\n\nThe evaluators who conduct the assessments will not know which group each participant belongs to, to ensure that the results are as objective as possible.",[454],"Chronic Pain",[456,457,458,459,460],"\"Pain Education\"","\"Patient Education\",","\"Exercise\"","\"Healthy Aging\"","\"Aged\"","2026-01-04",{"date":463,"type":40},"2026-01-07",{"date":465,"type":40},"2025-10-01",{"date":467,"type":21},"2026-08",{"name":46,"class":47},{"id":470,"slug":471,"hasResults":12,"nctId":472,"briefTitle":473,"officialTitle":474,"acronym":4,"eligibilityCriteria":475,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":476,"targetDuration":4,"studyType":22,"phases":478,"briefSummary":479,"conditions":480,"keywords":482,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":486,"lastUpdatePostDateStruct":487,"startDateStruct":489,"completionDateStruct":491,"leadSponsor":493,"locationsCount":4},"100616598","8-weeks-vs-12-weeks-physical-exercise-programmes-in-colorectal-cancer-patients-100616598","NCT07307690","8 Weeks vs 12 Weeks Physical Exercise Programmes in Colorectal Cancer Patients","Comparison of the Effectiveness of 8-week vs 12-week Physical Exercise Programmes in Patients With Colorectal Cancer","Inclusion Criteria:\n\n* People diagnosed with colorectal cancer and who are receiving chemotherapy treatment.\n* Sedentary people who have not performed physical activity in the last 8 weeks.\n* Ability to understand the evaluation tests and the performance of the exercises.\n* Presence of XXX symptoms (If we focus on neuropathy, it should be inclusion criteria).\n* Voluntary participation in the study.\n\nExclusion Criteria:\n\n\\- Present contraindication\u002Fs for physical exercise (musculoskeletal diseases, severe cardiovascular disease, bone metastases,...).",{"count":477,"type":21},50,[24],"Chemotherapy is a cornerstone in the treatment of colon cancer; however, its effects extend beyond malignant cells. Because chemotherapeutic agents target rapidly dividing cells, they can also damage healthy tissues, resulting in a range of adverse effects. Among the most prevalent is peripheral neuropathy, a disorder of the peripheral nervous system characterized by symptoms such as tingling, numbness, pain, and weakness in the extremities.\n\nChemotherapy-induced peripheral neuropathy poses a significant challenge for patients with colon cancer, as it further compromises quality of life during an already demanding phase of treatment. Damage to sensory and motor nerves interferes with the ability to perform daily activities and diminishes physical capacity, thereby intensifying both the physical and psychological burden associated with the disease.\n\nNevertheless, certain interventions may help mitigate these negative effects, with physical exercise emerging as a particularly promising strategy. Although it may appear counterintuitive, regular physical activity has been shown to exert beneficial effects on peripheral neuropathy. Exercise enhances blood circulation, supports the regeneration of damaged peripheral nerves, and helps reduce neuropathic pain and discomfort, ultimately improving functional performance.\n\nIt is important to emphasize that exercise interventions should be individually tailored and conducted under appropriate medical supervision. Consequently, the integration of chemotherapy with a carefully designed exercise program represents a comprehensive approach to managing both the disease and its treatment-related side effects, contributing to an improved quality of life for patients with colon cancer throughout their recovery process.",[252,481],"Chemotherapy-Induced Peripheral Neuropathy",[129,126,483,484,485],"Colorectal cancer","wellbeing","Mental health","2025-12-30",{"date":488,"type":40},"2026-01-06",{"date":490,"type":21},"2026-01-01",{"date":492,"type":21},"2026-06-01",{"name":46,"class":47},{"id":495,"slug":496,"hasResults":12,"nctId":497,"briefTitle":498,"officialTitle":499,"acronym":4,"eligibilityCriteria":500,"healthyVolunteers":87,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":501,"targetDuration":4,"studyType":22,"phases":503,"briefSummary":504,"conditions":505,"keywords":4,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":512,"lastUpdatePostDateStruct":513,"startDateStruct":515,"completionDateStruct":517,"leadSponsor":519,"locationsCount":48},"100616276","preparation-for-sports-retirement-study-protocol-100616276","NCT07303504","Preparation for Sports Retirement: Study Protocol","Preparation for Sports Retirement: Protocol for a Psychoeducational Program in a Randomized Controlled Trial","Inclusion Criteria:\n\n* Participants will be included if they are within the critical transition period, defined as:\n\nFive years prior to sports retirement, when the first signs of preparation and emotional anticipation begin.\n\nFive years after retirement, the stage in which identity, psychological, and professional adaptation processes are consolidated.\n\nThis interval reflects the progressive nature of adaptation to sports retirement.\n\nExclusion Criteria:\n\n* Athletes presenting any of the following conditions will be excluded from the study:\n\nSignificant literacy difficulties or relevant deficits in linguistic comprehension that prevent adequate participation in the psychoeducational sessions or the completion of assessment instruments.\n\nSevere unstabilized medical or psychological conditions that may interfere with the normal development of the program (e.g., untreated severe depressive episodes, limiting neurological disorders).\n\nFailure to meet the inclusion criteria, specifically not being within the five-year period prior to or after sports retirement or failing to verify high-performance sports experience.\n\nRefusal to sign the informed consent or lack of availability to regularly attend the program sessions.",{"count":502,"type":21},26,[24],"Background: This article presents the protocol for a randomised controlled trial designed to develop and evaluate a psychoeducational intervention aimed at preparing high-performance athletes for the challenges and opportunities presented by the transition to retirement from sport. The protocol was developed through a literature review and consultations with experts in sports psychology and career transition.\n\nMethods: The study will be conducted at the Faculty of Psychology of the University of Salamanca (Spain). High-performance athletes aged 30 or older who are close to retirement or who have retired in the last five years will be recruited. Participants will be randomly assigned to two groups: the intervention group, which will undergo a psychoeducational programme consisting of 12 sessions over 3 months; and the control group, which will receive a minimum educational programme of one session. All participants will complete initial and final assessments, as well as a 3-month follow-up, collecting sociodemographic data and applying various psychological, social and health assessment instruments.\n\nDiscussion: This protocol describes a comprehensive psychoeducational intervention aimed at improving quality of life and attitudes towards retirement from sport, increasing life satisfaction, psychological flexibility, perceived social support, general health, self-efficacy and self-regulation, and reducing negative stereotypes associated with the end of a sporting career. The evidence generated will guide future interventions, policies, and educational programmes to promote a healthy, active, and satisfying transition to the post-sport stage.",[506,507,508,509,510,511],"Sport Retirement","Psychoeducation","Retirement","Adaptation","Psychosocial Factors","Psychology","2025-12-26",{"date":514,"type":40},"2025-12-31",{"date":516,"type":21},"2026-02-01",{"date":518,"type":21},"2027-05-01",{"name":46,"class":47},{"id":521,"slug":522,"hasResults":12,"nctId":523,"briefTitle":524,"officialTitle":525,"acronym":4,"eligibilityCriteria":526,"healthyVolunteers":87,"sex":17,"minAge":426,"maxAge":4,"enrollmentInfo":527,"targetDuration":4,"studyType":22,"phases":529,"briefSummary":530,"conditions":531,"keywords":4,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":533,"lastUpdatePostDateStruct":534,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":538,"locationsCount":48},"100543875","nutritional-status-assessment-and-dietary-recommendations-program-venredi-100543875","NCT06361550","Nutritional Status Assessment and Dietary Recommendations Program (VENREDI)","Effectiveness of a Nutritional Intervention in Improving the Mediterranean Diet in Older Adults","Inclusion Criteria:\n\n* Be 60 years old, retired or in early retirement\n* Participate in the program \"Research in active aging with preventive physiotherapy - PReGe\"\n* Agree to participate in the study and sign the informed consent.\n\nExclusion Criteria:\n\n* Present any pathology that prevents carrying out the workshops appropriately.",{"count":528,"type":21},200,[24],"Introduction: The Mediterranean diet has been related to beneficial effects in the prevention of cardiovascular diseases and other chronic pathologies related to diet, including some types of cancer. Specifically in the elderly population, it has been observed that the Mediterranean diet is inversely associated with all causes of mortality and that the greater the adherence to this type of diet, the lower the mortality in elderly adults.\n\nObjective: To evaluate the effect of a multifactorial intervention (seminar on shopping basket and food labeling, workshop on healthy cooking and subsequent tasting of the prepared products) in improving adherence to the Mediterranean diet in older adults.\n\nMethodology: Randomized controlled clinical trial with two parallel groups: an intervention group (IG) and a control group (CG). The study population will be adults over 60 years of age, retired or pre-retired. A sample size of 200 participants has been estimated, 100 in each group to detect a difference of 0.83 points or more in the MEDAS questionnaire.\n\nAll participants will receive an educational talk on healthy nutrition, with an estimated duration of 2 hours. The GI, in addition to this educational workshop, will receive a practical seminar on how to properly carry out the shopping cart. This will take place both in a market and later in a supermarket in Salamanca. In addition, a workshop will be held where participants will prepare a menu consisting of three dishes (starter, main and dessert) and will later taste them.\n\nAn initial and post-intervention evaluation will be carried out after 3 months so that both groups can study the change variables related to Adherence to the Mediterranean Diet \\[Mediterranean Diet Adherence Questionnaire (MEDAS)\\], physical activity \\[Short physical performance battery (SPPB)\\], sleep quality (ATENAS questionnaire) and assessment of cognitive function (MOCA questionnaire).",[532],"Adherence to the Mediterranean Diet","2025-12-18",{"date":512,"type":40},{"date":536,"type":40},"2023-11-02",{"date":136,"type":21},{"name":46,"class":47},{"id":540,"slug":541,"hasResults":12,"nctId":542,"briefTitle":543,"officialTitle":543,"acronym":544,"eligibilityCriteria":545,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":546,"targetDuration":4,"studyType":22,"phases":548,"briefSummary":549,"conditions":550,"keywords":557,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":559,"lastUpdatePostDateStruct":560,"startDateStruct":562,"completionDateStruct":564,"leadSponsor":566,"locationsCount":4},"100614972","precision-physical-exercise-for-personalized-onco-hematology-100614972","NCT07286539","Precision Physical Exercise for Personalized Onco-Hematology.","PEPOH","Inclusión criteria:\n\n* Adult patients (≥18 years), capable of signing the informed consent and willing to participate in the study.\n* Performance status (ECOG) 0-2.\n* Specific inclusion criteria are defined for each cohort involved in the study as follows:\n\nLung cancer: Patients diagnosed with non-small cell lung carcinoma in metastatic stage, eligible for combined immunotherapy and chemotherapy, with active treatment.\n\nColorectal cancer: Patients with stage II, III, or IV resected colorectal cancer undergoing adjuvant chemotherapy.\n\nBreast cancer: Female patients with histologically confirmed hormone receptor-positive\u002FHER2-negative breast cancer, receiving active hormonal therapy (tamoxifen, aromatase inhibitor, or fulvestrant) in either adjuvant or stable metastatic phase.\n\nChronic lymphocytic leukemia (CLL): Patients diagnosed with CLL who have not received and are not in need of pharmacological treatment.\n\nMultiple myeloma (MM): Patients with a confirmed new diagnosis of MM under active first line treatment and non-candidates to autologous transplantation.\n\nExclusion criteria:\n\n* Presence of unstable bone metastases or extensive bone involvement associated with a high risk of fracture.\n* Uncontrolled cardiovascular, respiratory, musculoskeletal, or metabolic diseases that contraindicate physical exercise at the investigator's discretion.\n* Explicit medical contraindication to exercise training.\n* Documented poor adherence (\\\u003C80%).\n* Treatment discontinuation, disease progression, intolerance, or any other medical, personal, or logistical circumstance that, in the opinion of the investigators, may compromise participant safety or the integrity of the study.",{"count":547,"type":21},150,[24],"Physical exercise, particularly strength training, has become an effective strategy to improve physical function, muscle mass, and quality of life in cancer patients. However, the biological mechanisms underlying these benefits remain poorly understood, especially during active treatment. The PEPOH project (Precision physical Exercise for Personalized Onco-Hematology) proposes a single-center clinical trial conducted at the Fundación del Instituto de Investigación Biomédica de Salamanca (FIBSAL) including five different patient cohorts: lung, colorectal (CRC), and breast cancer, chronic lymphocytic leukemia, and multiple myeloma. Participants will be randomly assigned to either an in-person intervention group, performing a supervised strength training program twice a week for 12 weeks combined with a home-based exercise program, or a control group performing only the home-based program. Biological samples will be collected before and after the intervention for multi-dimensional characterization (Genomics, Transcriptomics, Proteomics and Metabolomics) and systematic integration with parameters of functional capacity, quality of life, psychological well-being, frailty, and body composition. The main objective of the project is to determine biological parameters associated with strength exercise and their relationship with clinical parameters related to prognosis, therapy response and survival. This multi-dimensional approach will enable the detection of exercise adaptation biomarkers and generate knowledge about the mechanisms linking exercise with improved health outcomes in individuals with cancer. PEPOH will contribute to biomedical science and will enhance the comprehensive care of oncohematologic patients by integrating multi-omic and clinical data into a precision exercise model. This project will also contribute to society by offering a cost-effective, safe, and transferable intervention, which increases the overall quality of life.",[551,552,553,554,555,556],"Hematologic Cancer","Colon Cancer","Breast Cancer","Lymphoma","Chronic Lymphocytic Leukemia (CLL)","Lung Cancer",[129,126,558],"Well-being","2025-12-12",{"date":561,"type":40},"2025-12-16",{"date":563,"type":21},"2026-04-01",{"date":565,"type":21},"2030-12-31",{"name":46,"class":47},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":574,"targetDuration":4,"studyType":22,"phases":575,"briefSummary":576,"conditions":577,"keywords":579,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":584,"lastUpdatePostDateStruct":585,"startDateStruct":587,"completionDateStruct":588,"leadSponsor":589,"locationsCount":4},"100612401","effects-of-a-resistance-physical-exercise-program-in-multiple-myeloma-patients-100612401","NCT07253103","Effects of a Resistance Physical Exercise Program in Multiple Myeloma Patients","\"Effects of a Resistance Physical Exercise Program in Multiple Myeloma Patients: A Randomized Controlled Trial Study Protocol\".","Inclusion criteria:\n\n* Confirmed diagnosis of MM undergoing active treatment.\n* No regular physical activity during the previous eight weeks.\n* Functional status (ECOG) 0-1.\n* Signature of informed consent.\n\nExclusion criteria:\n\n* Presence of medical contraindications for physical exercise, such as severe musculoskeletal disorders, severe cardiovascular disease, bone metastases, or other conditions that the medical team considers inappropriate.\n* Inability to complete the initial assessment tests or difficulty performing basic exercises.\n* Any other circumstance that, in the opinion of the investigators, may interfere with the objectives or conduct of the study.",{"count":477,"type":21},[24],"The goal of this clinical trial is to learn if physical exercise improves quality of life, frailty and mental health in patients with multiple myeloma. It will also learn about the safety and adherence of the program. The main questions it aims to answer are:\n\nDoes physical exercise improves quality of life in patients with multiple myeloma? Does physical exercise improves frailty and mental health in patients with multiple myeloma? Researchers will compare supervised physical exercise and home-based unsupervised physical exercise.\n\nParticipants will:\n\nParticipate in one of the exercise programs, supervised or home-based, for 12 weeks. They will be completely evaluated before and after the intervention.",[578,129,126],"Multiple Myeloma (MM)",[126,129,580,581,582,583],"Múltiple Myeloma","Physiotherapy","Protocol","Resistance","2025-11-24",{"date":586,"type":40},"2025-11-28",{"date":516,"type":21},{"date":110,"type":21},{"name":46,"class":47},{"id":591,"slug":592,"hasResults":12,"nctId":593,"briefTitle":594,"officialTitle":595,"acronym":4,"eligibilityCriteria":596,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":597,"enrollmentInfo":598,"targetDuration":4,"studyType":22,"phases":600,"briefSummary":601,"conditions":602,"keywords":604,"overallStatus":70,"whyStopped":4,"lastUpdateSubmitDate":610,"lastUpdatePostDateStruct":611,"startDateStruct":613,"completionDateStruct":615,"leadSponsor":617,"locationsCount":48},"100533815","emg-analysis-in-abi-motor-imagery-and-action-100533815","NCT06230718","EMG Analysis in ABI: Motor Imagery and Action","Upper Limb Electromyographic Response to Motor Imagery and Action Observation in Acquired Brain Injury Patients.","Inclusion Criteria:\n\n* Being over 18 years of age\n* Diagnoses of established stroke\n* Present limitations or motor response deficiencies in the upper limb\n* Maintain cognitive functions with the ability to follow the instructions of the interventions and evaluations (MOCA\\>14)\n\nExclusion Criteria:\n\n* Diagnosed with mental illness before the stroke\n* Other systemic conditions on the central nervous system\n* Cardiorespiratory system pathologies in severe cases\n* Acute period, fever, muscle inflammation or myopathies\n* Any type of vascular and organic insufficiency\n* Liver disease or skin lesions in the area of application of the electrodes.","99 Years",{"count":599,"type":21},28,[24],"This study focuses on electromyographic analysis of upper limb muscle activation in stroke survivors during Motor Imagery (MI) and Action Observation (AO) rehabilitation techniques. By measuring muscle activity in the wrist and finger flexors and extensors, the research seeks to understand the impact of MI and AO on motor function recovery post-stroke. Conducted at the University of Salamanca, the study involves stroke survivors participating in a series of three experimental sessions. The analysis will correlate electromyographic responses with functional independence, limb functionality, and cognitive factors. The research aims to contribute to the fields of occupational therapy and physiotherapy, offering insights into effective rehabilitation methods for improving quality of life in stroke survivors.",[188,332,603],"Mirror Movement",[605,606,607,608,609],"Stroke rehabilitation","Electromyography","Neuroplasticity","Upper Linb","Neurorehabilitation","2025-10-02",{"date":612,"type":40},"2025-10-07",{"date":614,"type":40},"2024-01-01",{"date":616,"type":21},"2027-01-30",{"name":46,"class":47},{"id":619,"slug":620,"hasResults":12,"nctId":621,"briefTitle":622,"officialTitle":623,"acronym":4,"eligibilityCriteria":624,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":625,"targetDuration":4,"studyType":22,"phases":626,"briefSummary":627,"conditions":628,"keywords":631,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":465,"lastUpdatePostDateStruct":634,"startDateStruct":636,"completionDateStruct":637,"leadSponsor":638,"locationsCount":4},"100608898","physical-exercise-in-patients-with-first-psychotic-episode-100608898","NCT07207538","Physical Exercise in Patients With First Psychotic Episode","Impact of Physical Exercise on Telomere Length and Other Markers of Premature Ageing in First-episode Psychosis.","Inclusion Criteria:\n\n* be at least 18 years of age\n* Having experienced a first psychotic episode in the last 3 years\n\nExclusion Criteria:\n\n* are unable to read and understand the patient information sheet and sign the informed consent form.",{"count":147,"type":21},[24],"Justification: Patients with first-episode psychosis are at increased risk of premature ageing and early mortality, associated with telomere shortening and increased inflammatory markers. Physical exercise has shown protective effects in the general population, but there are no intervention studies in this population.\n\nObjective: To evaluate the effect of a strength training programme on telomere length and other markers of cellular ageing in people with a first episode of psychosis.\n\nMaterial and methods: Quasi-experimental study with patients aged 18-35 years included in the PRINT programme (Salamanca). Standard treatment will be compared with standard treatment plus a 12-week strength training programme. Telomere length (qPCR), inflammatory and senescence markers (proteomics), body composition, frailty and quality of life will be analysed.\n\nApplicability: The results could support the inclusion of physical exercise programmes as a complementary intervention in early psychosis care, promoting overall health, quality of life and reducing the gap in life expectancy compared to the general population.",[629,129,630],"Telomere Length","First Episode Psychosis (FEP)",[129,632,633],"Telomere length","Aging",{"date":635,"type":40},"2025-10-06",{"date":490,"type":21},{"date":166,"type":21},{"name":46,"class":47},{"id":640,"slug":641,"hasResults":12,"nctId":642,"briefTitle":643,"officialTitle":644,"acronym":4,"eligibilityCriteria":645,"healthyVolunteers":12,"sex":17,"minAge":449,"maxAge":4,"enrollmentInfo":646,"targetDuration":4,"studyType":22,"phases":648,"briefSummary":649,"conditions":650,"keywords":655,"overallStatus":36,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":667,"locationsCount":4},"100599285","effects-of-exercise-cognitive-training-and-their-combination-in-institutionalized-older-adults-100599285","NCT07082504","Effects of Exercise, Cognitive Training, and Their Combination in Institutionalized Older Adults","Effects of Physical Exercise Programs, Cognitive Stimulation, and Their Combination on Mobility, Cognitive Function, and Psychosocial Well-Being in Institutionalized Older Adults","Inclusion Criteria:\n\n* Individuals of both sexes.\n* Age 65 years or older.\n* Retired.\n* Institutionalized for more than three months.\n* Provide informed consent and agree to participate.\n\nExclusion Criteria:\n\n* Lack of cooperation or cognitive capacity to participate.\n* Diagnosis of dementia or Alzheimer's disease.\n* Presence of acute medical conditions.\n* Physical or cognitive impairments that prevent completion of study procedures.",{"count":647,"type":21},140,[24],"The goal of this clinical trial is to learn if physical exercise, cognitive stimulation, or a combination of both can improve mobility, cognitive function, and psychosocial well-being in institutionalized older adults aged 65 and older. The main questions it aims to answer are:\n\n* Does physical exercise improve strength, flexibility, balance, and mobility?\n* Does cognitive stimulation improve executive function and mental state?\n* Does combining both interventions provide greater benefits than either intervention alone?\n\nResearchers will compare the physical exercise group, the cognitive stimulation group, and the combined group to a control group that receives no active intervention to see which approach leads to the most improvement.\n\nParticipants will:\n\n* Take part in either physical exercise, cognitive stimulation, or both, 3 times per week for 12 weeks\n* Complete assessments before the intervention, after 12 weeks, and again after 6 months\n* Answer questionnaires and perform physical and cognitive tests to measure changes in health and well-being",[633,651,652,653,654],"Institutionalized Older Adults","Cognitive Abilities","Mobility and Independence","Well-being\u002FQuality of Life",[656,657,658,332,659,434,660],"Physical Exercise","Cognitive Stimulation","Executive Function","Elderly Adults","Dual-Task Training","2025-07-15",{"date":663,"type":40},"2025-07-24",{"date":665,"type":21},"2025-09-01",{"date":134,"type":21},{"name":46,"class":47},""]