[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Santiago de Compostela\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":327},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,11,0,[8,48,79,106,133,164,193,220,248,277,305],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100542133","brief-problem-solving-intervention-in-different-formats-for-the-prevention-of-suicide-in-adults-over-50-100542133",false,"NCT06338904","Brief Problem-solving Intervention in Different Formats for the Prevention of Suicide in Adults Over 50","Efficacy of a Brief Poblem-solving Based Psychological Intervention Implemented in Different Formats for the Indicated Prevention of Suicide in Adults Over 50","SOLPROSU50+","Inclusion Criteria:\n\n* Be at least 50 years old\n* Reside in Galicia\n* Present suicidal ideation\n\nExclusion Criteria:\n\n* Present serious mental health or medical disorders\n* Have begun receiving psychological or psychopharmacological treatment in the previous two months or are participating in other suicide prevention research\n* Do not have an appropriate mobile device or sufficient fluency to communicate in Spanish, or have problems that make it impossible to participate\n* Plan to move in the next 18 months.","ALL","50 Years",{"count":20,"type":21},212,"ESTIMATED","INTERVENTIONAL",[24],"NA","Suicide represents a personal tragedy and an enormous global public health problem. One of the most vulnerable groups is adults 50 years and older. Despite this stage of life is particularly amenable to the implementation of targeted suicide prevention strategies, we have few studies of the efficacy of psychological interventions, those that do exist have methodological limitations, and none were implemented in formats other than face-to-face, which limits their accessibility. There is a need for brief psychological interventions that can be administered in both face-to-face and remote formats, do not require long training periods, and are effective in different contexts: for example, problem-solving therapy. The main objective of this project is to evaluate the efficacy of a brief problem-solving psychological intervention for targeted suicide prevention in people aged 50 years and older, administered in face-to-face, conference call, and smartphone app formats. A randomized controlled trial will be performed. Participants will be recruited through healthcare centers in the Autonomous Community of Galicia (Spain). To be included, participants must: (a) be at least 50 years old, (b) reside in Galicia, and (c) present suicidal ideation. Subjects will be excluded if they: (a) present serious mental health or medical disorders; (b) have begun receiving psychological or psychopharmacological treatment in the previous two months or are participating in other suicide prevention research; (c) do not have an appropriate mobile device or sufficient fluency to communicate in Spanish, or have problems that make it impossible to participate; or (d) plan to move in the next 18 months. At pre-intervention information will be collected on sociodemographic, family, personal history, current suicide risk and other clinical variables. 212 participants will be randomly assigned to (1) a problem-solving-based psychological intervention delivered face-to-face (PSPI-FF; experimental group 1); (2) a problem-solving-based psychological intervention delivered via telephone conference call (PSPI-CC; experimental group 2); (3) a problem-solving-based psychological intervention delivered via a smartphone app (PSPI-A; experimental group 3); or (4) a usual care control group (UCCG). Participants in the experimental groups will complete the six sessions\u002Fmodules of the interventions. Finally, subjects in all groups will be evaluated at post-intervention and 3, 6 and 12-month follow-ups.",[27],"Suicide",[29,30,31,32,33,34],"randomized controlled trial","prevention","problem solving","conference call","App","Adults over 50","RECRUITING","2026-04-28",{"date":38,"type":39},"2026-05-05","ACTUAL",{"date":41,"type":39},"2023-09-01",{"date":43,"type":21},"2026-05-31",{"name":45,"class":46},"University of Santiago de Compostela","OTHER",1,{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":54,"eligibilityCriteria":55,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":22,"phases":60,"briefSummary":61,"conditions":62,"keywords":64,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":74,"completionDateStruct":76,"leadSponsor":78,"locationsCount":47},"100585332","therapeutic-contact-intensity-in-a-psychological-smoking-cessation-intervention-with-an-app-100585332","NCT06900985","Therapeutic Contact Intensity in a Psychological Smoking Cessation Intervention With an App","Assessment of a Psychological Treatment for Smoking Cessation Combined With an App According to the Intensity of Therapeutic Contact: Randomized Controlled Trial","TREATINTSMOKE","Inclusion Criteria:\n\n* aged 18 or over\n* wishing to participate in the treatment\n* providing written informed consent\n* smoking at least 5 cigarettes per day\n* completion of all pre-treatment assessment questionnaires\n* having a valid email address\n* having an Android or iOS smartphone and being willing to use it throughout the treatment\n\nExclusion Criteria:\n\n* a diagnosis of severe mental disorder (bipolar disorder and\u002For psychotic disorder)\n* concurrent substance use disorder (alcohol, cannabis, stimulant, hallucinogen and\u002For opioid)\n* using other tobacco products (electronic cigarette with nicotine, cigars or cigarillos)\n* having completed an effective psychological treatment to quit smoking during the previous year\n* having completed a pharmacological treatment to quit smoking in the last year (any smoking cessation medication approved by the Agencia Española del Medicamento)\n* having a physical pathology involving high vital risk that requires immediate intervention (e.g., recent myocardial infarction)\n* having visual difficulties that prevent the use of the App.",true,"18 Years",{"count":59,"type":21},429,[24],"This randomized controlled trial intends to examine the efficacy of a smoking cessation intervention with an App according to the intensity of therapeutic contact. Participants will be assigned to one of three groups. The first group will receive eight sessions with trained psychologists alongside access to the App. The second group will receive four sessions with trained psychologists plus App access. The control group will only have access to the App. This study seeks to determine the impact of different levels of therapeutic contact on abstinence outcomes.",[63],"Smoking Behaviors",[65,66,67,68,69,70,29],"smoking","treatment","cognitive-behavioral","therapeutic-contact intensity","digital intervention","eHealth","NOT_YET_RECRUITING","2026-04-27",{"date":36,"type":39},{"date":75,"type":21},"2026-09",{"date":77,"type":21},"2028-04",{"name":45,"class":46},{"id":80,"slug":81,"hasResults":11,"nctId":82,"briefTitle":83,"officialTitle":84,"acronym":4,"eligibilityCriteria":85,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":86,"targetDuration":4,"studyType":22,"phases":88,"briefSummary":89,"conditions":90,"keywords":94,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":47},"100629630","mineral-trioxide-aggregate-mta-vs-gutta-percha-for-non-surgical-endodontic-retreatment-in-teeth-with-apical-lesions-100629630","NCT07477171","Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions","Comparison of Two Root Canal Filling Materials in Non-Surgical Endodontic Retreatment: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\nPatients ≥18 years old American Society of Anesthesiologists (ASA) physical status I and II Teeth requiring non-surgical endodontic retreatment Periapical lesion ≤10 mm in maximum diameter on periapical radiograph Apical canal diameter ≤ size 50 Teeth without periodontal defects or mobility\n\nExclusion Criteria:\n\nSmokers Teeth with insufficient remaining tooth structure Teeth requiring surgical retreatment Primary endodontic treatment complications (fractured instrument, perforation, ledge or apical transportation)",{"count":87,"type":21},58,[24],"The main objective of this study is to compare the healing rate of periapical lesions after non-surgical endodontic retreatment in teeth obturated with gutta-percha versus those obturated with mineral trioxide aggregate (MTA), with a 12-month follow-up. Secondary objectives include evaluating differences between groups in healing time, postoperative pain, and tooth discoloration.",[91,92,93],"Periapical Diseases","Root Canal Therapy","Mineral Trioxide Aggregate (MTA)",[95,96,97],"non-surgical endodontic retreatment","bioceramic","gutta-percha","2026-03-18",{"date":100,"type":39},"2026-03-23",{"date":102,"type":21},"2026-03",{"date":104,"type":21},"2027-04",{"name":45,"class":46},{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":113,"targetDuration":4,"studyType":22,"phases":115,"briefSummary":116,"conditions":117,"keywords":120,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":125,"lastUpdatePostDateStruct":126,"startDateStruct":128,"completionDateStruct":130,"leadSponsor":132,"locationsCount":4},"100628773","perma-based-mobile-psychological-intervention-with-and-without-telephone-support-for-university-students-100628773","NCT07466004","PERMA-Based Mobile Psychological Intervention With and Without Telephone Support for University Students","Efficacy of a Positive Psychology-Based Psychological Intervention Grounded in the PERMA Model Delivered Via Smartphone App, With and Without Telephone Multiconference Support, for the Promotion of Psychological Well-Being in University Students","Inclusion Criteria:\n\n* Being an actively enrolled university student at the University of Santiago de Compostela (USC)\n* Having access to a smartphone with an internet connection.\n\nExclusion Criteria:\n\n* Having a current diagnosis of severe psychiatric disorder, including major depressive disorder with psychotic features, bipolar disorder, schizophrenia, severe cognitive impairment, dissociative disorders, or active substance dependence\n* Having started psychological or psychopharmacological treatment within the two months prior to the study or participating in another mental health-related study\n* Having insufficient proficiency in Spanish, or presenting sensory, cognitive, or physical impairments that would prevent engagement with the intervention\n* Planning to move out of Galicia within the next 12 months.",{"count":114,"type":21},177,[24],"University students face increasing academic and psychosocial demands that place them at risk of reduced psychological well-being. Positive psychology interventions have demonstrated efficacy in promoting mental health; however, few are grounded explicitly in Seligman's PERMA model and adherence to digital interventions remains limited. This randomized controlled trial aims to evaluate the efficacy of a brief PERMA-based psychological intervention delivered via a smartphone application, with and without supplementary telephone multiconference support, compared to a waiting list control group. The intervention consists of five weekly modules targeting Positive Emotion, Engagement, Relationships, Meaning, and Accomplishment. Assessments will be conducted at baseline, post-intervention, and at six-month follow-up.",[118,119],"Psychological Well Being","Mental Health Promotion",[121,122,123,124],"PERMA model","University students","Mobile intervention","Randomized controlled trial","2026-03-06",{"date":127,"type":39},"2026-03-12",{"date":129,"type":21},"2026-09-01",{"date":131,"type":21},"2029-08-31",{"name":45,"class":46},{"id":134,"slug":135,"hasResults":11,"nctId":136,"briefTitle":137,"officialTitle":138,"acronym":4,"eligibilityCriteria":139,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":140,"targetDuration":4,"studyType":22,"phases":142,"briefSummary":143,"conditions":144,"keywords":150,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":156,"lastUpdatePostDateStruct":157,"startDateStruct":159,"completionDateStruct":161,"leadSponsor":163,"locationsCount":4},"100619335","nursing-health-education-to-improve-functionality-and-quality-of-life-after-ischemic-stroke-100619335","NCT07343284","Nursing Health Education to Improve Functionality and Quality of Life After Ischemic Stroke","Effect of a Nursing Intervention Based on Health Education on Functionality, Depression Symptoms, and Quality of Life in Patients With Ischemic Stroke: A Quasi-Experimental, Longitudinal, and Prospective Clinical Trial","Inclusion Criteria:\n\n* Anterior or posterior cerebral occlusion\n\nExclusion Criteria:\n\n* Intracranial hemorrhage\n* Pregnancy\n* Cognitive incapacity for participation\n* Refusal to participate in the study and administer the questionnaires.",{"count":141,"type":21},70,[24],"This study is titled \"Effect of a Nursing Intervention Based on Health Education on Functionality, Depression Symptoms, and Quality of Life in Patients with Ischemic Stroke.\" It is a quasi-experimental, longitudinal, prospective clinical trial that will beconducted with patients who have suffered an ischemic stroke and were treated in the neurology unit of the Lucus Augusti University Hospital, the same center where this study will take place.\n\nThe primary objective of the study is to determine the effect of a nursing intervention based on health education on quality of life and depression symptoms in individuals who have experienced an ischemic stroke.\n\nTo achieve this objective, variables such as cognitive status, depression symptoms, autonomy and ability to perform basic activities of daily living, neurological deficits, and quality of life will be assessed.\n\nRegarding the total number of subjects to be studied, according to the Stroke Atlas in Galicia published by the Spanish Society of Neurology in 2018, the autonomous community of Galicia had a population of 2,701,819 inhabitants. Applying an incidence rate of 187.4 cases per 100,000 inhabitants according to the IBERICTUS study, an estimated 5,064 new stroke cases occur each year in Galicia. The province of Lugo had 324,842 inhabitants as of January 1, 2024, according to the INE; therefore, applying the same incidence rate, an estimated 609 new stroke cases occur per year. Considering the proportion of ischemic strokes compared to other types of strokes (80:20), the estimated number of ischemic stroke cases in Lugo would be 487. The representative sample size of stroke patients in the province of Lugo would be 70 patients, with 35 patients receiving the intervention and 35 serving as controls.\n\nIndependent Variables:\n\nSociodemographic: sex, age, event date. Clinical: stroke type, treatment modality (rt-PA or thrombectomy), falls, pain, pressure ulcers, aspiration, pneumonia, dysphagia, vital signs.\n\nHealth education: received vs. not received.\n\nDependent Variables:\n\nCognitive status (MMSE). Depression symptoms (BDI). Autonomy and ADL performance (Barthel Index). Neurological deficits (NIHSS). Quality of life (European Quality of Life Scale).\n\nInstruments Mini-Mental State Examination (MMSE) Beck Depression Inventory (BDI) Barthel Index NIH Stroke Scale (NIHSS) Visual Analogue Scale (VAS) European Quality of Life Scale (EQLS)",[145,146,147,148,149],"Ischemia Stroke","Post-stroke Depression","Post-stroke","Quality of Life","Health Education",[151,152,153,154,155],"Ischemic stroke","Nursing","Depression","Health education","Quality of life","2026-01-07",{"date":158,"type":39},"2026-01-15",{"date":160,"type":21},"2026-06-01",{"date":162,"type":21},"2027-12-01",{"name":45,"class":46},{"id":165,"slug":166,"hasResults":11,"nctId":167,"briefTitle":168,"officialTitle":169,"acronym":4,"eligibilityCriteria":170,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":171,"targetDuration":4,"studyType":22,"phases":173,"briefSummary":174,"conditions":175,"keywords":177,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":187,"completionDateStruct":189,"leadSponsor":191,"locationsCount":192},"100594368","vertical-soft-tissue-augmentation-with-tent-pole-technique-and-its-influence-on-marginal-bone-loss-around-dental-implants-100594368","NCT07018531","Vertical Soft Tissue Augmentation With Tent Pole Technique and Its Influence on Marginal Bone Loss Around Dental Implants","Vertical Soft Tissue Augmentation Using the Tent-Pole Technique With Adjunctive Therapies and Its Influence on Marginal Bone Loss Around Dental Implants: A Randomized Controlled Clinical Trial","Inclusion Criteria:\n\n* Participants must be over 18 years of age. They should be legally capable of adhering to study protocols, which include maintaining proper oral hygiene, attending all scheduled follow-up visits, fully understanding the proposed surgical procedures, and signing the informed consent form.\n* single edentulous sites in the premolar and\u002For molar region of the mandible.\n* Vertical gingival thickness must be more than 1 mm and less than or equal to 2 mm.\n* A minimum of 2 mm of attached gingiva should be present on both the buccal and lingual sides of the implant sites.\n* Buccal bone thickness must be at least 1.5 mm.\n\nExclusion Criteria:\n\n* Presence of general contraindications for dental implants or surgical interventions.\n* Heavy smoking, defined as more than 10 cigarettes daily, including pipe, vape or cigar use.\n* Poor oral hygiene, characterized by probing depths greater than 4 mm in adjacent teeth, and a full mouth plaque score (FMPS) or full mouth bleeding score (FMBS) exceeding 25% after the pre-treatment phase.\n* Guided bone regeneration at the implant site.\n* History of conditions or diseases that compromise bone metabolism (e.g. Paget's disease, osteoporosis) or current use of medications that may affect bone metabolism (e.g. bisphosphonates).\n* History of cancer or prior radiotherapy or chemotherapy treatments for malignancy.\n* Uncontrolled diabetes.\n* Current pregnancy or breastfeeding status.\n* Allergies to any products involved in the study.",{"count":172,"type":21},112,[24],"This study aims to evaluate the effectiveness of the tent pole technique in vertical peri-implant soft tissue augmentation and to assess its impact on marginal bone loss. Additionally, the adjunctive use of platelet-rich fibrin and photobiomodulation will be explored to determine their influence on the clinical outcomes of this procedure.",[176],"Soft Tissue Augmentation Around Dental Implants",[178,179,180,181,182,183],"Dental Implants","Vertical Soft Tissue","Tent Pole Technique","Platelet-Rich Fibrin","Photobiomodulation","Marginal Bone Loss","2025-06-12",{"date":186,"type":39},"2025-06-17",{"date":188,"type":21},"2025-07",{"date":190,"type":21},"2026-08",{"name":45,"class":46},2,{"id":194,"slug":195,"hasResults":11,"nctId":196,"briefTitle":197,"officialTitle":198,"acronym":199,"eligibilityCriteria":200,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":201,"targetDuration":4,"studyType":22,"phases":203,"briefSummary":205,"conditions":206,"keywords":208,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":212,"lastUpdatePostDateStruct":213,"startDateStruct":215,"completionDateStruct":217,"leadSponsor":219,"locationsCount":47},"100571046","phase-4-non-surgical-treatment-of-peri-implantitis-with-systemic-azithromycin-or-placebo-100571046","NCT06715150","Non-Surgical Treatment of Peri-implantitis with Systemic Azithromycin or Placebo","NON-SURGICAL TREATMENT of PERI-IMPLANTITIS with or WITHOUT SYSTEMIC AZITHROMYCIN: a RANDOMIZED CLINICAL TRIAL in HUMANS","NSTP","Inclusion Criteria:\n\n* older than 18 years;\n* absence of systemic pathology contraindicating treatment;\n* presence of at least 1 implant diagnosed with peri-implantitis: presence of bleeding on probing, probing depth ≥6 mm, and radiographic bone level ≥3 mm apical to the most coronal portion of the intraosseous part of the implant;\n* absence of implant mobility;\n* patients without periodontitis or with treated periodontitis;\n* patients who understand the treatment and are willing to comply with it by providing written informed consent.\n\nExclusion Criteria:\n\n* smokers ≥10 cigarettes\u002Fday;\n* diabetic patients (HbA1c level ≥6,5%);\n* pregnant or breastfeeding women;\n* use of antibiotics, corticosteroids, and\u002For immunosuppressive treatment in the 3 months prior to the start of the study;\n* allergy to azithromycin;\n* patients with a history of bisphosphonate treatment;\n* chronic consumption of non-steroidal anti-inflammatory drugs;\n* bone loss exceeding the apex of the implant;\n* prosthesis that does not allow access to peri-implantitis treatment",{"count":202,"type":21},52,[204],"PHASE4","The primary objective of this study is to evaluate the change in probing depth in patients with peri-implantitis, assessing the influence of systemic antibiotic (azithromycin) adjunctive to non-surgical treatment at 12 months. The secondary objective is to assess clinical, radiographic, microbiological, and systemic changes at 3, 6, and 12 months.\n\nThis study is designed as a placebo-controlled, randomized, triple-blind clinical trial in subjects diagnosed with peri-implantitis.\n\nThe treatment will consist of debridement of the implant surface and curettage of the pocket epithelium. The control group will receive placebo (1 placebo tablet per day for 3 days), and the test group will receive systemic azithromycin 500 mg per day for 3 days (1 tablet of 500 mg azithromycin per day for 3 days).",[207],"Peri-implantitis",[209,210,211],"Non-surgical treatment","Azithromycin","Systemic antibiotic","2024-12-04",{"date":214,"type":39},"2024-12-10",{"date":216,"type":21},"2025-01-10",{"date":218,"type":21},"2027-01-10",{"name":45,"class":46},{"id":221,"slug":222,"hasResults":11,"nctId":223,"briefTitle":224,"officialTitle":225,"acronym":4,"eligibilityCriteria":226,"healthyVolunteers":56,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":227,"targetDuration":4,"studyType":22,"phases":229,"briefSummary":230,"conditions":231,"keywords":238,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":241,"startDateStruct":243,"completionDateStruct":245,"leadSponsor":247,"locationsCount":47},"100461493","efficacy-of-the-vacucis-candida-autovaccine-100461493","NCT05289375","Efficacy of the Vacucis Candida® Autovaccine","Efficacy of the Vacucis Candida® Autovaccine in the Management of Chronic Oral Candidiasis. Randomized Triple-blind Randomized Clinical Trial.","Inclusion Criteria:\n\n* Patients with a history of RT in the head and neck region that directly or indirectly involves any of the jaws.\n* Adult patients\n* Hemodynamically stable patients without contraindications to receive an autovaccine (see exclusion)\n* Patients with a stable oncological situation without active tumor\n* Patients who present candidiasis demonstrated by clinical examination (signs and symptoms of candidiasis) and microbiological (culture).\n\nExclusion Criteria:\n\n* Minor patients\n* Pregnant patients\n* Patients with an unstable medical situation, both from a hemodynamic and oncological point of view (advanced tumors with metastases, recurrences or inoperable tumors)\n* Patients undergoing treatment with CT that involves an affectation of the immune system\n* Patient under treatment with antifungals for mycoses of any origin\n* Allergy to the active substance or to any of the other components of Vacucis.\n* Serious disorders of the immune system.\n* Diseases that severely affect immunity.\n* Presence of fever.\n* People with allergies to yeasts\n* People with allergy to chloramphenicol\n* Patients treated with MAOIs (monoamine oxidase inhibitors)",{"count":228,"type":21},46,[24],"Introduction: Oral candidiasis is an infectious disease caused by the growth of Candida colonies and their penetration into oral tissues when physical barriers and host defenses are weakened. It constitutes one of the most common pathologies within the field covered by Dentistry. Candida infections are found in at least 80% of AIDS patients and in a third of HIV infection cases. Systemic diseases such as diabetes and a wide pharmacological arsenal to which the general population is subjected, are other causes of the increase in the prevalence of this disease. In addition, the high prevalence of oral sequelae (hyposialia) in the population over 65 years of age, due to the specific characteristics of this age group, such as multiple pathologies and drug use, explains the presence of this disease in this segment. of the population One of the great difficulties for the study of this disease is the diversity of predisposing factors, which do nothing but throw greater confusion into the results of the different works.\n\nObjective: To evaluate the reduction\u002Fsuppression of signs and symptoms of oral candidiasis in patients treated with head and neck RT, users of Vacucis or Placebo.\n\nMaterial and method: Patients will receive information regarding the trial and, if they meet the inclusion criteria and agree to participate in it, they will sign the informed consent. All patients will be informed following the usual care practice of the characteristics of their candidiasis infection as well as the possibilities and alternatives of treatment and their respective efficacy.\n\nA descriptive analysis of the sample in terms of prevalence will be carried out. Categorical variables will be described as frequency and percentage and continuous variables as mean and standard deviation or median and interquartile range depending on their adjustment to normality, which will be calculated with the Kolmogorov-Smirnov test. To study the effect of the vaccine on the evolution of candidiasis, the Chi-square test, Student's t test or the non-parametric Mann-Whitney test will be used. The association of prevalence with CFU in both groups will be analyzed using the ANOVA test. Those values of p \\\u003C 0.05 will be considered significant.",[232,233,234,235,236,237],"Oral Candidiasis","Oral Candidiasis Recurrent","Radiotherapy; Complications","Candida Albicans Infection","Microbial Colonization","Xerostomia",[239],"oral candidiasis","2024-10-15",{"date":242,"type":39},"2024-10-17",{"date":244,"type":21},"2025-04-30",{"date":246,"type":21},"2027-12-31",{"name":45,"class":46},{"id":249,"slug":250,"hasResults":11,"nctId":251,"briefTitle":252,"officialTitle":253,"acronym":254,"eligibilityCriteria":255,"healthyVolunteers":56,"sex":17,"minAge":256,"maxAge":4,"enrollmentInfo":257,"targetDuration":4,"studyType":22,"phases":259,"briefSummary":260,"conditions":261,"keywords":264,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":240,"lastUpdatePostDateStruct":271,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":47},"100407354","role-of-the-dentist-in-the-control-of-the-alcoholic-habit-in-patients-with-potentially-malignant-oral-lesions-100407354","NCT04584333","Role of the Dentist in the Control of the Alcoholic Habit in Patients with Potentially Malignant Oral Lesions","Randomised Clinical Trial on the Role of the Dentist in the Control of the Alcoholic Habit, in Elderly Patients with Potentially Malignant Oral Lesions","ALCODENT","Inclusion Criteria:\n\n1. Patients with a clinical and histopathological diagnosis of oral lichen planus (OPL) and\u002For oral leukoplakia (LO) (in all its clinical forms) as chronic LOPMs according to the WHO 2017 classification.\n2. Patients over 40 years old\n3. Patients in follow-up, with chronic injuries, without medical and\u002For surgical treatment for at least 1 month\n4. Patients with frequent daily alcohol consumption \\> 1 Standard Beverage Unit (more than two glasses of wine\u002Fbeer per day or one glass of liquor\u002Fdistilled drink per day)\n\nExclusion Criteria:\n\n1. Participants who do not sign the informed consent.\n2. Patients with a score above 20 in the AUDIT.\n3. Patients undergoing treatment for problems with alcohol and other drugs.\n4. Patients with systemic pathology associated with alcohol consumption\n5. Pregnant patients.\n6. Patients undergoing active pharmacological treatment for OPL.\n7. Patients who have undergone surgical resection and\u002For CO2 laser treatment for LO in the last month.\n8. Patients with a history of malignant oral lesions.","40 Years",{"count":258,"type":21},206,[24],"Introduction: Alcohol is the most consumed psychoactive substance, its consumption is very prevalent and there is a low perception of the risk it poses in our society. Alcohol is a risk factor and a causal factor for multiple pathologies, including cancer and potentially malignant oral lesions (LOPM). The dentist can play a relevant role in the evaluation of consumption, as well as provide brief interventions (BI) to assist them in the cessation of the habit.\n\nObjectives: The main objective is to evaluate the efficacy of the intervention, carried out by dentists, to stop or reduce alcohol consumption in a patient with LOPM.\n\nMaterial and methods: clinical trial, randomized, with balanced randomization, single-blind (for the evaluator of the results) with 1 experimental arm and a control group, carried out in a single-center manner. Group 1 incident brief intervention and Group 2 no incident intervention (only usual clinical information). 200 patients from the Unit of Oral Medicine, Oral Surgery and Implantology of the University of Santiago de Compostela will participate in this study, they will make an initial visit, one month, three months, six months and one year. In these visits, evaluations related to alcohol consumption, the evolution of injuries, quality of life and satisfaction with the BI were carried out.\n\nPredictable results: If IB contributes to the cessation or reduction of alcohol consumption, and improves the clinical evolution of LOPM, it could be implemented immediately in our Oral Medicine unit and could lay the foundations for its implementation in different public centers and private.",[262,263],"Oral Potentially Malignant Disorders","Alcohol Drinking",[265,266,267,268,269,270],"Alcohol Abuse","Substance Abuse","Monitoring Program","Dentistry","Health Promotion","Clinical trial",{"date":242,"type":39},{"date":273,"type":39},"2021-03-01",{"date":275,"type":21},"2026-09-30",{"name":45,"class":46},{"id":278,"slug":279,"hasResults":11,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":56,"sex":284,"minAge":57,"maxAge":4,"enrollmentInfo":285,"targetDuration":4,"studyType":22,"phases":287,"briefSummary":288,"conditions":289,"keywords":292,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":304,"locationsCount":47},"100562909","anxiety-is-one-of-the-most-frequent-disorders-during-the-perinatal-stage-which-is-associated-with-adverse-health-effects-for-women-and-their-babies-this-study-will-be-to-evaluate-the-effectiveness-of-a-telematic-cognitive-behavioral-preventive-intervention-to-manage-anxiety-during-pregnancy-100562909","NCT06609291","Anxiety is One of the Most Frequent Disorders During the Perinatal Stage Which is Associated with Adverse Health Effects for Women and Their Babies. This Study Will Be to Evaluate the Effectiveness of a Telematic Cognitive-behavioral Preventive Intervention to Manage Anxiety During Pregnancy.","Telematic Prenatal Psychological Intervention for Preventing Anxious Symptomatology","Inclusion Criteria:\n\n* Women over 18 years of age living in the Region of Galicia (Spain)\n* Pregnant with a gestational age ≤ 16\n* Understand and speak Spanish fluently\n* Informed consent to participate in the study\n* Accessibility to the internet and a digital device ( computer, tablet or smartphone)\n\nExclusion Criteria:\n\n* High-risk pregnancy or twins\n* Being pharmacological treatment for anxiety and\u002For depression\n* Not giving their consent","FEMALE",{"count":286,"type":21},130,[24],"Anxiety is one of the most frequent disorders during the perinatal stage which is associated with adverse health effects for women and their babies. In spite of this, preventive interventions during this stage are scarce. The National Institute for Health and Clinical Excellence recommends psychological interventions, such as cognitive behavioral therapy, as a first-line treatment for mild and moderate prenatal anxiety. Early detention of anxiety symptoms in the perinatal stage can help prevent the development of more serious mental health problems. However, there are barriers to accessing interventions during this period. A long-distance intervention carried out during the pregnancy can be an effective and accessible resource to help improve women's emotional state. The primary objective of the current study is to determine whether a preventive psychological intervention developed through videoconferencing is superior to the usual care during pregnancy (attendance at pregnancy follow-up consultations and information and answers to frequently asked questions provided by the midwife) to prevent anxious symptoms during pregnancy. The secondary objective is to examine whether this same intervention is more effective than usual care in preventing depressive symptoms during pregnancy, as well as anxious and depressive symptoms in the postpartum.\n\nA random clinical trial will be carried out among pregnant women in Spain. A recruitment of 130 participants is proposed with random assignment to one of two conditions (65 per group): (a) the experimental group will receive the cognitive-behavioral intervention via videoconference or (b) the control group will receive usual care pregnancy (attendance at pregnancy follow-up consultations and information and answers to frequently asked questions provided by the midwife).\n\nThe psychological intervention will take place via videoconference in seven weekly sessions, lasting one hour each, with groups of 6 - 8 pregnant women. A blinded assessment will be conducted through online self-administered testing at baseline, post-intervention, and at follow-up at one month, 3 and 6 months. A clinical interview will also be conducted to evaluate generalized anxiety disorder (GAD), at the same time times. Our primary hypothesis is that the intervention will decrease the frequency of women who present anxious symptomatology during pregnancy. The second objective is to analyze the effectiveness of this intervention to prevent depressive symptomatology during pregnancy, as well as postpartum anxious and depressive symptomatology.",[290,291],"Anxiety Disorder (Panic Disorder or GAD)","Anxiety Symptoms",[30,293,294,295,296],"telematic","pregnancy","perinatal anxiety","perinatal depression","2024-09-23",{"date":299,"type":39},"2024-09-25",{"date":301,"type":21},"2024-12",{"date":303,"type":21},"2025-12",{"name":45,"class":46},{"id":306,"slug":307,"hasResults":11,"nctId":308,"briefTitle":309,"officialTitle":309,"acronym":4,"eligibilityCriteria":310,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":311,"enrollmentInfo":312,"targetDuration":4,"studyType":22,"phases":314,"briefSummary":315,"conditions":316,"keywords":4,"overallStatus":71,"whyStopped":4,"lastUpdateSubmitDate":319,"lastUpdatePostDateStruct":320,"startDateStruct":322,"completionDateStruct":324,"leadSponsor":326,"locationsCount":47},"100548532","phase-4-an-oral-doxycycline-regimen-to-prevent-bacteremia-following-dental-procedures-100548532","NCT06422221","An Oral Doxycycline Regimen to Prevent Bacteremia Following Dental Procedures","Inclusion Criteria:\n\n* Subjects must have at least 10 teeth.\n* Subjects must have the need for a dental extraction under general anesthesia (for behavioral reasons).\n* Subjects will be recruited regardless of the extent and severity of their dental and\u002For periodontal disease.\n\nExclusion Criteria:\n\n* Age under 18 years\n* Body weight under 40 kg\n* Receipt of antibiotics in the previous 3 months\n* Routine use of oral antiseptics\n* A history of allergy or intolerance to doxycycline\n* A history of allergy or intolerance to cindamycin\n* Any type of congenital or acquired immunodeficiency\n* Any known risk factor for bacterial endocarditis\n* Any known risk factor for prolonged bleeding","65 Years",{"count":313,"type":21},150,[204],"Although controversy exists regarding the efficacy of antibiotic prophylaxis for patients at risk of infective endocarditis, expert committees continue to publish recommendations for antibiotic prophylactic regimens. The last American Heart Association (AHA) and European Society of Cardiology (ESC) guidelines include several important changes, highlighting that clindamycin (CLI) is no longer recommended as an alternative to amoxicillin in those allergic to penicillin. This new project aims to evaluate the effectiveness of oral doxycycline in preventing post-dental extraction bloodstream infection.",[317,318],"Bacteremia","Endocarditis","2024-06-13",{"date":321,"type":39},"2024-06-17",{"date":323,"type":21},"2024-07-15",{"date":325,"type":21},"2025-06-30",{"name":45,"class":46},""]