[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Seville\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":717},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,27,0,25,[9,50,71,97,136,166,189,227,252,281,317,341,370,402,429,450,477,500,528,554,582,608,639,667,691],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":31,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":39,"lastUpdatePostDateStruct":40,"startDateStruct":43,"completionDateStruct":45,"leadSponsor":47,"locationsCount":4},"100637378","effectiveness-and-implementation-of-a-personalized-mhealth-intervention-for-the-universal-prevention-of-maternal-perinatal-mental-disorders-100637378",false,"NCT07613008","Effectiveness and Implementation of a Personalized mHealth Intervention for the Universal Prevention of Maternal Perinatal Mental Disorders","Universal Prevention of Maternal Perinatal Mental Disorders and Its Implementation as Normalized Routine Practice (e-Perinatal): A Cluster Randomized Hybrid Effectiveness-Implementation Trial","ePerinatal-RCT","Inclusion Criteria:\n\n\\- Inclusion Criteria (Women)\n\nMust receive an invitation to participate from a healthcare professional at one of the participating primary healthcare centers\n\nMust be pregnant for at least 11 weeks at the time of enrollment\n\nMust be at least 18 years old\n\nMust have access to a mobile phone and internet connection\n\nMust be able to read, write, and understand Spanish\n\nMust have a personal email account\n\nNo diagnosis of depression or anxiety disorder at baseline Forma\n\n\\- Inclusion Criteria (Partners or significant others)\n\nMust receive an invitation to participate from a woman already enrolled in the study\n\nMust be at least 18 years old\n\nMust have access to a mobile phone and internet connection\n\nMust be able to read, write, and understand Spanish\n\nMust have a personal email account\n\nExclusion Criteria:\n\n* Exclusion Criteria (Women)\n\nCurrent diagnosis of depression or anxiety disorder\n\nReceiving psychological or pharmacological treatment for mental health or substance use conditions\n\n\\- Exclusion criteria for partners (or significant others):\n\nThere are no exclusion criteria for partners",true,"ALL","18 Years",{"count":22,"type":23},3000,"ESTIMATED","INTERVENTIONAL",[26],"NA","This study is part of the ERC-funded e-Perinatal project and represents a large-scale hybrid type 1 effectiveness-implementation cluster randomized controlled trial. The primary aim is to evaluate the effectiveness of a personalized and complex mobile health (mHealth) intervention (e-Perinatal) in the universal prevention of maternal perinatal depression and anxiety disorders. Secondary aims include evaluating the impact on paternal mental health and child development, as well as examining implementation outcomes in real-world primary healthcare settings.",[29,30],"Perinatal Depression","Perinatal Anxiety",[32,33,34,35,36,37],"Depression","Anxiety","Perinatal","Prevention","mHealth","Implementation","NOT_YET_RECRUITING","2026-05-25",{"date":41,"type":42},"2026-05-29","ACTUAL",{"date":44,"type":23},"2026-05-30",{"date":46,"type":23},"2028-03-30",{"name":48,"class":49},"University of Seville","OTHER",{"id":51,"slug":52,"hasResults":12,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":56,"eligibilityCriteria":57,"healthyVolunteers":18,"sex":58,"minAge":20,"maxAge":4,"enrollmentInfo":59,"targetDuration":4,"studyType":24,"phases":60,"briefSummary":61,"conditions":62,"keywords":63,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":68,"completionDateStruct":69,"leadSponsor":70,"locationsCount":4},"100639051","feasibility-and-implementation-of-early-referral-in-perinatal-mental-health-100639051","NCT07609550","Feasibility and Implementation of Early Referral in Perinatal Mental Health","Feasibility, Acceptability, and Preliminary Effectiveness of Early Referral Strategy to Specialized Mental Health Services: An Embedded Implementation Study","e-Perinatal-Re","Inclusion Criteria:\n\n* Pregnant and postpartum women enrolled in the main e-Perinatal trial, indicating the presence of a depressive or anxiety disorder with CIDI.\n* Access to smartphone and internet\n* Able to write and read in Spanish\n\nExclusion Criteria:\n\n* None beyond those defined in the main trial","FEMALE",{"count":22,"type":23},[26],"This study is part of the e-Perinatal project and is embedded within the main cluster randomized trial. The primary aim is to evaluate the feasibility, acceptability, and preliminary effectiveness of an early diagnosis detection and referral strategy to specialized mental health services within routine maternal care. The secondary aim is to validate and implement an Artificial Intelligence-based algorithm for the early screening of mental health disorders in routine services.",[29,30],[32,33,34,64,36,37],"Referral","2026-05-19",{"date":67,"type":42},"2026-05-27",{"date":44,"type":23},{"date":46,"type":23},{"name":48,"class":49},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":24,"phases":82,"briefSummary":83,"conditions":84,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":88,"lastUpdatePostDateStruct":89,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},"100622746","effectiveness-of-the-copca-program-in-infants-at-risk-of-neurodevelopmental-disorders-100622746","NCT07387627","Effectiveness of the COPCA Program in Infants at Risk of Neurodevelopmental Disorders","Effectiveness of the Coping With and Caring for Infants With Special Needs Program in Infants at Risk of Neurodevelopmental Disorders. A Comparison With Conventional Pediatric Physiotherapy Models and Parent Training","COPCA","Inclusion Criteria:\n\n* Infants at risk of neurodevelopmental disorders.\n* Participation in pediatric physiotherapy and\u002For Early Intervention programs at the time of study inclusion, regardless of the reference center.\n* Corrected age under 12 months at the time of recruitment.\n\nExclusion Criteria:\n\n* Infants with confirmed neurodevelopmental disorders at the time of inclusion.\n* Presence of additional medical conditions requiring complex medical or surgical interventions that could interfere with participation in the study (e.g., recent or planned surgery).\n* Severe family socio-communicative difficulties that limit participation in coaching sessions (e.g., significant language barriers).","12 Months",{"count":81,"type":23},40,[26],"The purpose of this clinical trial is to evaluate whether the COPCA® program (Coping with and Caring for Infants with Special Needs) is more effective than conventional pediatric physiotherapy and parent education in improving development in infants at risk of neurodevelopmental disorders, as well as empowering their families.\n\nThis study will include infants younger than 12 months of corrected age who are at risk of neurodevelopmental disorders and are currently receiving early intervention or pediatric physiotherapy services, together with their parents or primary caregivers.\n\nThe main questions this study aims to answer are:\n\nDoes the COPCA® program improve motor development and functional abilities in infants at risk of neurodevelopmental disorders more than conventional pediatric physiotherapy or parent education?\n\nDoes the COPCA® program increase family empowerment and improve parents' perception of the care they receive compared with traditional intervention models?\n\nThe researchers will compare outcomes across four study groups:\n\nIn-person COPCA® intervention\n\nOnline COPCA® intervention\n\nParent education group\n\nConventional pediatric physiotherapy group\n\nParticipants will be randomly assigned to one of the four groups. The intervention period will last 6 months, with assessments conducted at the start of the study, during the intervention, and during follow-up.\n\nInfants will take part in age-appropriate daily activities and play situations. Parents or caregivers will actively participate in the intervention sessions and will be supported in learning how to promote their child's development during everyday routines.\n\nThe study will assess infant motor development, functional abilities, overall development, family empowerment, and parents' perception of family-centered care using validated assessment tools and interviews. The results of this study may help improve early intervention strategies for infants at risk of neurodevelopmental disorders and support more family-centered approaches to care.",[85,86],"Neurodevelopmental Disorders","Neurodevelopmental Disorders and Developmental Abnormalities","RECRUITING","2026-04-28",{"date":90,"type":42},"2026-04-29",{"date":92,"type":42},"2026-02-10",{"date":94,"type":23},"2027-06-01",{"name":48,"class":49},1,{"id":98,"slug":99,"hasResults":12,"nctId":100,"briefTitle":101,"officialTitle":101,"acronym":4,"eligibilityCriteria":102,"healthyVolunteers":12,"sex":58,"minAge":20,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":24,"phases":105,"briefSummary":106,"conditions":107,"keywords":122,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":128,"lastUpdatePostDateStruct":129,"startDateStruct":131,"completionDateStruct":133,"leadSponsor":135,"locationsCount":96},"100577203","efficacy-of-physical-therapy-treatment-in-endometriosis-and-its-relationship-to-adherence-rates-100577203","NCT06795243","Efficacy of Physical Therapy Treatment in Endometriosis and Its Relationship to Adherence Rates.","Inclusion Criteria:\n\n* Adult women (over 18 years of age) diagnosed with endometriosis.\n* Women with the capacity to carry out a therapeutic program based on muscular exercise.\n* Women with the capacity to understand the requirements of the study.\n\nExclusion Criteria:\n\n* Women undergoing fertility and\u002For assisted reproduction treatment.\n* Pregnant women.",{"count":104,"type":23},32,[26],"The main objective of this study is to know if the application of both therapies, neuroscience pain education plus therapeutic exercise will modify pain, catastrophizing and quality of life in endometriosis.",[108,109,110,111,112,113,114,115,116,117,118,119,120,121],"Endometriosis","Endometriosis Related Pain","Endometriosis, Pain","Endometriosis-related Pain","Pain","Pain Intensity Assessment","Pain Management","Pain, Chronic Disease","Pain Score","Therapeutic Exercise","Exercise Adherence","Adherence, Treatment","Treatment Adherence and Compliance","Quality of Life",[108,109,110,112,113,114,123,124,125,126,119,120,127],"Pain, chronic disease","pain score","therapeutic exercise","exercise adherence","Quality of life","2026-03-30",{"date":130,"type":42},"2026-04-06",{"date":132,"type":42},"2025-05-01",{"date":134,"type":23},"2026-07-01",{"name":48,"class":49},{"id":137,"slug":138,"hasResults":12,"nctId":139,"briefTitle":140,"officialTitle":141,"acronym":142,"eligibilityCriteria":143,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":144,"targetDuration":4,"studyType":24,"phases":146,"briefSummary":147,"conditions":148,"keywords":150,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":158,"lastUpdatePostDateStruct":159,"startDateStruct":161,"completionDateStruct":163,"leadSponsor":165,"locationsCount":4},"100631483","analgesic-effect-of-a-biophotonic-foot-massage-cream-100631483","NCT07501273","Analgesic Effect of a Biophotonic Foot Massage Cream","Analgesic Effect of a Biophotonic Foot Massage Cream: A Randomized Clinical Trial","No acronym","Inclusion Criteria:\n\n* Adults aged 18 years or older.\n* Patients attending the Podiatry Clinical Area of the University of Seville.\n* Presence of musculoskeletal pain in one or both feet at the initial assessment.\n* Ability to understand the study information and provide written informed consent.\n* Ability to follow study instructions and complete study assessments.\n* Intact skin at the application site.\n\nExclusion Criteria:\n\n* Foot pain of non-musculoskeletal origin, or pain mainly attributable to infectious, vascular, tumoral, severe neurological, or decompensated systemic diseases.\n* Wounds, ulcers, burns, dermatitis, skin infections, or any active skin disorder at the application site.\n* Known allergy, hypersensitivity, or previous adverse reaction to any component of the investigational cream or placebo.\n* Concomitant use of analgesic, anti-inflammatory, or topical treatments on the foot that may interfere with efficacy assessment, unless a washout period is established.\n* Recent infiltrations, surgery, or invasive treatment on the foot or ankle that may alter pain evolution during the study.\n* Pregnancy or breastfeeding.",{"count":145,"type":23},170,[26],"This study aims to evaluate the effectiveness of a biophotonic cosmetic massage cream in reducing musculoskeletal foot pain in adults. Participants with pain in one or both feet attending the Podiatry Clinical Area of the University of Seville will be randomly assigned to receive either the investigational cream or a placebo cream with similar characteristics. The assigned product will be applied topically to the painful area twice daily for 10 consecutive days. Pain intensity, pressure pain threshold, foot function, and health-related quality of life will be assessed during the study.",[149],"Musculoskeletal Pain",[151,152,153,154,155,156,157],"Foot pain","Musculoskeletal pain","Biophotonic cream","Topical treatment","Placebo","Randomized clinical trial","Podiatry","2026-03-28",{"date":160,"type":42},"2026-04-02",{"date":162,"type":23},"2026-09-01",{"date":164,"type":23},"2027-09-01",{"name":48,"class":49},{"id":167,"slug":168,"hasResults":12,"nctId":169,"briefTitle":170,"officialTitle":171,"acronym":4,"eligibilityCriteria":172,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":173,"enrollmentInfo":174,"targetDuration":4,"studyType":24,"phases":176,"briefSummary":177,"conditions":178,"keywords":4,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":181,"lastUpdatePostDateStruct":182,"startDateStruct":184,"completionDateStruct":186,"leadSponsor":188,"locationsCount":4},"100624663","instrumental-assessment-of-plantar-hyperkeratosis-in-healthy-subjects-and-patients-with-diabetes-100624663","NCT07412561","Instrumental Assessment of Plantar Hyperkeratosis in Healthy Subjects and Patients With Diabetes","Comparative Diagnostic Evaluation of Non-Invasive Instrumental Methods for Assessing Plantar Hyperkeratosis in Healthy Subjects and Patients With Diabetes Mellitus Without Active Ulceration","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Presence of at least one clinically identifiable plantar hyperkeratosis\n* Intact skin without ulceration\n* Ability to maintain standing position for at least 30 seconds\n* Signed informed consent\n\nAdditional Inclusion Criteria for Diabetes Mellitus Group:\n\n* Medical diagnosis of type 1 or type 2 diabetes mellitus\n* No active foot ulcer\n* No history of foot ulcer within the previous 12 months\n\nExclusion Criteria:\n\n* Active plantar ulcer, pre-ulcerative lesion, or recent ulcer scar\n* Severe peripheral neuropathy (absence of protective sensation with 10 g monofilament)\n* Severe peripheral arterial disease (Ankle-Brachial Index \\\u003C 0.8)\n* Foot surgery within the previous 6 months\n* Active inflammatory, infectious, or dermatological condition at measurement site\n* Use of keratolytic treatments or debridement within the previous 15 days\n* Inability to complete the full assessment protocol","90 Years",{"count":175,"type":23},50,[26],"This randomized clinical trial aims to compare the diagnostic performance, reproducibility, and agreement of several non-invasive instrumental methods for assessing plantar hyperkeratosis hardness in healthy subjects and patients with diabetes mellitus without active foot ulceration.\n\nParticipants will be evaluated in a single study session using plantar pressure platform analysis, durometer measurements, ultrasound elastography, and infrared thermography. The study seeks to identify the most reliable and discriminative methods for clinical and preventive assessment of plantar hyperkeratosis, particularly in populations at risk for diabetic foot complications.",[179,180],"Diabetes Mellitus","Hyperkeratosis","2026-02-11",{"date":183,"type":42},"2026-02-17",{"date":185,"type":23},"2026-02",{"date":187,"type":23},"2026-06",{"name":48,"class":49},{"id":190,"slug":191,"hasResults":12,"nctId":192,"briefTitle":193,"officialTitle":194,"acronym":195,"eligibilityCriteria":196,"healthyVolunteers":18,"sex":19,"minAge":197,"maxAge":198,"enrollmentInfo":199,"targetDuration":4,"studyType":24,"phases":201,"briefSummary":202,"conditions":203,"keywords":212,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":219,"lastUpdatePostDateStruct":220,"startDateStruct":222,"completionDateStruct":224,"leadSponsor":226,"locationsCount":96},"100620766","deciphering-the-effect-of-moderate-wine-consumption-on-healthy-aging-through-postprandial-extracellular-vesicles-100620766","NCT07361887","Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles.","Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles","(WINEVOME)","Inclusion Criteria\n\n* Healthy adult men and women aged 35 to 65 years.\n* Body Mass Index (BMI) between 18.5 and 29.9 kg\u002Fm².\n* Non-smokers or ex-smokers for at least 12 months.\n* Moderate alcohol consumers, defined as ≤2 units\u002Fday for men and ≤1 unit\u002Fday for women.\n* Normal fasting glucose and lipid profile at screening.\n* Willing and able to refrain from alcohol, polyphenol-rich foods, and intense exercise for 48 hours before each study visit.\n* Able to understand the study procedures and provide written informed consent.\n\nExclusion Criteria\n\n* History or clinical evidence of cardiovascular, hepatic, renal, thyroid, gastrointestinal, or metabolic diseases (including diabetes, dyslipidemia, or hypertension).\n* Use of medications or supplements known to affect glucose, lipid, or inflammatory metabolism (e.g., statins, corticosteroids, anti-inflammatory drugs).\n* Pregnancy or breastfeeding.\n* Recent blood donation (within the last 3 months) or planned blood donation during the study period.\n* Major weight change (\\>5% of body weight) within the last 3 months.\n* Participation in another clinical or biomedical study within the previous 3 months.\n* Known allergy or intolerance to wine, alcohol, or its components (e.g., sulfites).\n* History of alcohol abuse or inability to abstain from alcohol outside the study context.\n* Reluctance to receive information about incidental health findings arising from the study.\n* Any condition judged by the investigators to limit compliance or increase study risk (e.g., psychiatric disorders, inability to adhere to fasting requirements).","35 Years","36 Years",{"count":200,"type":23},8,[26],"This study aims to investigate how moderate wine consumption influences circulating extracellular vesicles (EVs) in healthy adults. EVs are small particles released by cells that carry proteins, lipids, and genetic material, and play important roles in communication between cells. Participants will consume a single serving of red or white wine, and blood samples will be collected before and after consumption to study changes in the composition and function of EVs. The study will also assess how these EVs affect vascular, immune, and brain-related cells. The results are expected to improve our understanding of how moderate wine intake contributes to cardiovascular and brain health.",[204,205,206,207,208,209,210,211],"Atherosclerosis Cardiovascular Disease","Obesity","Metabolic Syndrome","Metabolic Disorders","Inflammation","Neurodegeneration","Neurodegenerative Disease","Alzheimer s Disease",[213,214,215,216,217,218],"blood-brain barrier","microglia","extracellular vesicles","lipidome","proteome","vascular disease","2026-01-14",{"date":221,"type":42},"2026-01-23",{"date":223,"type":42},"2025-11-01",{"date":225,"type":23},"2027-03-31",{"name":48,"class":49},{"id":228,"slug":229,"hasResults":12,"nctId":230,"briefTitle":231,"officialTitle":232,"acronym":4,"eligibilityCriteria":233,"healthyVolunteers":12,"sex":19,"minAge":234,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":24,"phases":238,"briefSummary":239,"conditions":240,"keywords":242,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":245,"lastUpdatePostDateStruct":246,"startDateStruct":248,"completionDateStruct":249,"leadSponsor":251,"locationsCount":96},"100616136","physiotherapy-in-pediatric-oncology-100616136","NCT07301684","Physiotherapy in Pediatric Oncology","Analysis of a Multimodal Physiotherapy Treatment in Pediatric and Adolescent Cancer Survivors: A Randomized Clinical Trial","Inclusion Criteria:\n\n* Patients who have completed cancer treatment and are currently in remission, referred by their oncologist.\n* Children and adolescents aged 3 to 16 years.\n* Patients with a stable medical condition, without severe or acute complications related to cancer or its treatments.\n* Patients whose informed consent (from parents\u002Flegal guardians, in this case, as they are minors) has been obtained to participate in this study.\n* Patients with sufficient physical capacity to tolerate the activities proposed by the program.\n\nExclusion Criteria:\n\n* Severe comorbidities: neuromuscular, cardiovascular, or respiratory diseases that prevent participation in the exercise program or interfere with the assessment of physical function.\n* Incompatible medical treatments: patients currently receiving active treatments or with medical contraindications for electrotherapy or participation in exercise programs.\n* Severe psychological issues: children with severe psychological disorders or cognitive disabilities that may hinder understanding and participation in the sessions.\n* Visual impairments: patients with visual problems will not be able to participate, as this may interfere with the analysis of results related to the use of devices and video games for exercise.\n* Participation in other clinical trials: patients already involved in other research that could interfere with the results of this study.","3 Years","16 Years",{"count":237,"type":23},45,[26],"The objective of this clinical trial is to determine whether therapeutic physical exercise combined with electrotherapy and exercise gaming improves rehabilitation outcomes in pediatric and adolescent cancer patients.\n\nThe main questions it aims to answer are:\n\nDoes the combination of therapeutic physical exercise plus muscle strengthening and therapeutic physical exercise plus gamification, compared to a single exercise intervention, improve patient condition? Does gamified exercise improve treatment adherence? Does electrotherapy improve muscle activity when used in muscle strengthening mode? Researchers will test the application of the described modalities and assess improvements in variables such as cardiorespiratory fitness, physical activity self-efficacy, pain, balance, joint range of motion, physical activity level, cancer-related fatigue, quality of life, anxiety-depression, sleep, kinesophobia, and social status.",[241],"Cancer",[243,244],"pediatrics","oncology","2026-01-07",{"date":247,"type":42},"2026-01-09",{"date":185,"type":23},{"date":250,"type":23},"2026-09",{"name":48,"class":49},{"id":253,"slug":254,"hasResults":12,"nctId":255,"briefTitle":256,"officialTitle":257,"acronym":4,"eligibilityCriteria":258,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":259,"targetDuration":4,"studyType":24,"phases":261,"briefSummary":262,"conditions":263,"keywords":265,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":273,"lastUpdatePostDateStruct":274,"startDateStruct":276,"completionDateStruct":278,"leadSponsor":280,"locationsCount":4},"100609402","virtual-reality-music-and-education-to-reduce-anxiety-in-patients-undergoing-ingrown-toenail-surgery-100609402","NCT07214116","Virtual Reality, Music, and Education to Reduce Anxiety in Patients Undergoing Ingrown Toenail Surgery","Effectiveness of Educational Intervention, Virtual Reality, and Music Therapy on Anxiety in Onychocryptosis Surgery","Inclusion Criteria:\n\n* Adults aged 18 years or older of any sex.\n* Diagnosed with ingrown toenail (onychocryptosis) requiring surgical treatment.\n* Cognitive ability to understand study information, follow instructions, and complete questionnaires.\n\nExclusion Criteria:\n\n* Patients requiring ingrown toenail surgery associated with another pathology or surgical technique (e.g., subungual exostosis, chondroma, foreign bodies, tenotomies, etc.).\n* Patients with difficulties understanding Spanish.\n* Patients with visual or auditory disabilities preventing full use of the educational video, virtual reality, or headphones.\n* Patients with a diagnosis of trait anxiety, depression, or any emotional disorder.\n* Patients under psychiatric treatment.\n* Patients with chronic foot pain.\n* Patients receiving treatment for chronic pain.\n* Patients with epilepsy.\n* Patients with severe vertigo.\n* Patients with current facial injuries or burns.\n* Patients under treatment for blood pressure.\n* Patients with coagulation disorders.\n* Patients with active infections.\n* Pregnant women.",{"count":260,"type":23},175,[26],"The main objective of this clinical trial is to evaluate whether watching an educational video before surgery, combined with the use of virtual reality or music during surgery, can reduce anxiety and pain in people undergoing ingrown toenail (onychocryptosis) surgery.\n\nThe main questions the study aims to answer are:\n\nAre the educational video, virtual reality, and music effective in controlling and reducing pain and anxiety during surgery compared to traditional surgery?\n\nAs a distraction technique, is virtual reality or music more effective in reducing pain and anxiety during surgery?\n\nDo these interventions produce changes in patients' physiological parameters during surgery?\n\nIs there a relationship between patients' sociodemographic characteristics and their level of anxiety when undergoing surgery?\n\nThree study groups will be compared to determine the effect of each intervention:\n\nExperimental Group 1: watch a 5-minute educational video before entering the operating room and use virtual reality glasses with a 360° immersive video of a relaxing walk in the forest during surgery.\n\nExperimental Group 2: watch the 5-minute educational video before surgery and listen to carefully selected instrumental music through noise-canceling headphones during surgery.\n\nControl Group: surgery performed in the traditional way, without an educational video, virtual reality, or music.\n\nAll participants will complete questionnaires to assess anxiety, pain, and satisfaction before and after surgery.",[264],"Ingrown Toenail",[266,267,268,269,270,157,271,272],"Ingrown toenail","Onychocryptosis","Virtual reality","Music therapy","Educational video","Pain management","preoperative anxiety","2025-10-02",{"date":275,"type":42},"2025-10-09",{"date":277,"type":23},"2025-10",{"date":279,"type":23},"2027-01",{"name":48,"class":49},{"id":282,"slug":283,"hasResults":12,"nctId":284,"briefTitle":285,"officialTitle":286,"acronym":287,"eligibilityCriteria":288,"healthyVolunteers":18,"sex":19,"minAge":289,"maxAge":290,"enrollmentInfo":291,"targetDuration":4,"studyType":24,"phases":293,"briefSummary":294,"conditions":295,"keywords":301,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":96},"100608937","cultural-adaptation-validation-and-evaluation-of-the-programme-for-promotion-of-healthy-affective-sexual-behaviours-in-adolescents-iyg-100608937","NCT07208045","Cultural Adaptation, Validation, and Evaluation of the Programme for Promotion of Healthy Affective-Sexual Behaviours in Adolescents (IYG)","Es tu Juego: Decide Bien [It's Your Game: Keep It Real]. Cultural Adaptation, Validation, and Evaluation of the Programme for Promotion of Healthy Affective-Sexual Behaviours in Adolescents","IYG","Inclusion Criteria:\n\n* Adolescents aged between 11 and 14 years enrolled in compulsory secondary education (E.S.O).\n* Access to a computer and internet at their educational centre.\n\nExclusion Criteria:\n\n* Presence of linguistic, cognitive, or sensory barriers that prevent completion of the questionnaire\n* Participation in another programme aimed at preventing affective-sexual risk behaviours.","11 Years","14 Years",{"count":292,"type":23},1200,[26],"The investigators are writing to inform participants about a study being carried out by a research group from the University of Granada and the University of Seville, in which the participant's son\u002Fdaughter is invited to participate. The study has been approved by the Provincial Research Ethics Committee of Granada under code 202499906944441.\n\nThe sole intention of the investigators is to ensure that participants receive correct and sufficient information to assess and decide whether or not to give consent for the child's participation in this study. The information sheet should be read carefully, and any questions may be addressed to the investigators.\n\nThe objective of the study is to culturally adapt the program It's Your Game: Keep it Real (IYG), which aims to prevent risky sexual and affective behaviors in adolescents. The IYG program consists of 12 lessons, each lasting 45 minutes. These lessons aim to help the child identify personal norms and boundaries regarding sexuality, recognize situations that might challenge these boundaries, and develop refusal skills to maintain them. The program also covers topics such as the characteristics of healthy and unhealthy relationships, friendships, anatomy and reproduction, the social, emotional, and physical consequences of sexual activity, the consequences of teenage pregnancy and STIs, condom and contraceptive use, and communication skills.\n\nThis adaptation will involve the child completing all 12 lessons (two lessons per week over a period of six weeks) that make up the IYG program, as well as filling out a series of questionnaires. These questionnaires will allow the investigators to assess the usability of the program in Spain (including ease of use, comprehension, acceptability, as well as aspects most liked and suggestions for improvement).\n\nParticipation is entirely VOLUNTARY AND ANONYMOUS, and consent may be withdrawn at any time, without providing any explanation and without this affecting the care the child will receive in any way.\n\nIn all cases, the CONFIDENTIALITY of the data collected will be maintained in accordance with the European Union General Data Protection Regulation (GDPR) 2016\u002F679 and the Spanish Organic Law on the Protection of Personal Data and Guarantee of Digital Rights (LOPD-GDD) 3\u002F2018, of December 5.\n\nRegarding the study results, these may be shared with the scientific community through presentations, conferences, and\u002For publications.\n\nThe investigators express appreciation in advance for cooperation in this study.",[296,297,298,299,300],"Sexual Behavior","Sexually Transmitted Disease (STD)","Condom Use","Adolescent Health","Cultural Adaptation",[302,303,304,305,306,307,308],"sexually behaviour","sex education","adolescents","health education","cultural adaptation","evidence-based prevention","school health","2025-09-28",{"date":311,"type":42},"2025-10-08",{"date":313,"type":23},"2025-10-01",{"date":315,"type":23},"2027-06-30",{"name":48,"class":49},{"id":318,"slug":4,"hasResults":12,"nctId":319,"briefTitle":320,"officialTitle":321,"acronym":4,"eligibilityCriteria":322,"healthyVolunteers":12,"sex":19,"minAge":323,"maxAge":20,"enrollmentInfo":324,"targetDuration":4,"studyType":24,"phases":326,"briefSummary":327,"conditions":328,"keywords":4,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":333,"lastUpdatePostDateStruct":334,"startDateStruct":336,"completionDateStruct":338,"leadSponsor":340,"locationsCount":96},"100606404","NCT07175116","Advanced Dressings for CVC Infection Prevention in PICU","Use of Advanced Fixation Dressings in Reducing Central Venous Catheter-related Bloodstream Infections in a Paediatric Intensive Care Unit","Inclusion Criteria:\n\n* Admission to paediatric intensive care unit (PICU)\n* Central venous catheter placement (central or peripherally inserted)\n* Informed consent obtained from parent\u002Flegal guardian\n\nExclusion Criteria:\n\n* Known immunological disorders\n* Neutropenia (\\\u003C500\u002Fmm³)\n* Pre-existing colonisation or infection with multidrug-resistant organisms","2 Months",{"count":325,"type":23},250,[26],"Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections (CVC-BSI) in paediatric patients admitted to a tertiary hospital PICU. Outcomes include incidence of BRCVC, catheter colonisation, dressing-related skin complications, and number of dressing changes.",[329,330,331,332],"Catheter-Related Infections","Central Venous Catheters","Bloodstream Infection","Pediatric Intensive Care Units","2025-09-11",{"date":335,"type":42},"2025-09-16",{"date":337,"type":42},"2024-05-01",{"date":339,"type":23},"2025-11-15",{"name":48,"class":49},{"id":342,"slug":343,"hasResults":12,"nctId":344,"briefTitle":345,"officialTitle":345,"acronym":4,"eligibilityCriteria":346,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":347,"targetDuration":4,"studyType":24,"phases":348,"briefSummary":349,"conditions":350,"keywords":354,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":362,"lastUpdatePostDateStruct":363,"startDateStruct":365,"completionDateStruct":367,"leadSponsor":369,"locationsCount":96},"100601152","evaluation-of-the-family-intervention-program-pif-100601152","NCT07106775","Evaluation of the Family Intervention Program (PIF)","Inclusion Criteria:\n\n* Being a psychosocial at-risk family with at least one child under 18 years of age\n* Living in the territory that corresponds to that social services center\n\nExclusion Criteria:\n\n* Experience family crisis that prevent for participating in the home intervention\n* Experience mental health issue that prevent for participating in the home intervention\n* High level of psychosolcial risk",{"count":175,"type":23},[26],"The goal of this study is to evaluate the effectiveness of home positive parenting programs targeted to families at psychosocial risk carried out in Cantabria (Spain).\n\nThe investigators will collect information before the intervention, and every six months until the family achieves the proposed objectives (with a maximum intervention period of two years). Besides, the investigators will compare these results with information from other families that are not taking part in the program. Depending on the case, the practitioners in charge of the intervention, the main caregivers of the participating families and\u002For the adolescents will provide the information for the study.\n\nThe investigators expect that families participating in the programs will improve their parenting competencies, their family dynamics, and the life quality of their children.",[351,352,353],"Parenting","Children\u002FAdolescent Adjustment","Family Functioning",[355,356,357,358,359,360,361],"Positive parenting","Parenting competences","Program evaluation","Family functioning","Parenting practices","Effectiveness","Home program","2025-08-11",{"date":364,"type":42},"2025-08-14",{"date":366,"type":42},"2025-01-15",{"date":368,"type":23},"2026-05",{"name":48,"class":49},{"id":371,"slug":372,"hasResults":12,"nctId":373,"briefTitle":374,"officialTitle":374,"acronym":375,"eligibilityCriteria":376,"healthyVolunteers":12,"sex":19,"minAge":377,"maxAge":378,"enrollmentInfo":379,"targetDuration":4,"studyType":24,"phases":381,"briefSummary":382,"conditions":383,"keywords":387,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":394,"lastUpdatePostDateStruct":395,"startDateStruct":397,"completionDateStruct":399,"leadSponsor":401,"locationsCount":96},"100600748","using-technologies-to-promote-healthy-lifestyles-in-adolescents-with-intellectual-disabilities-100600748","NCT07101523","Using Technologies to Promote HEalthy Lifestyles in Adolescents With Intellectual Disabilities","IDHEAPP","Inclusion Criteria:\n\n* Diagnosis of intellectual disability\n* Being able to follow basic instructions\n* Age between 4-30 years old\n\nExclusion Criteria:\n\n* presence of severe sensory or motor impairments\n* medical conditions that contraindicated moderate physical activity\n* unable to access an smartphone during the intervention","4 Years","30 Years",{"count":380,"type":23},60,[26],"IDHEApp will implement various educational technology tools and work with the families, teachers and caregivers to increase physical activity (PA) and improve healthy eating. Due to the current COVID-19 pandemic restrictions, the use of innovative digital technology can contribute not just to distance learning but also to support families and students in remote. However, both healthy habits and technologies are insufficiently addressed in the population with IDD. These needs are in line with the following objectives of the Erasmus+ programme: a) Inclusion and diversity in all fields of education, training, youth and sport; b) Addressing digital transformation through development of digital readiness, resilience and capacity, and c) Encouraging the participation in sport and physical activity.\n\nEducators will find innovative possibilities and the right instruments that will enable them to fulfil their potential through innovative online education \\& learning \\& training skills module for lifestyle promotion and others available on the app. Furthermore, mentors and others health professionals (e.g., nursing etc.) will be equipped with knowledge and skills on how to use the app to teach practical skills for PA enhancement in an evidence-based way. Consequently, this project will contribute to \\[specific objectives - SO\\]:\n\n\\- Raise awareness of the importance of healthy and active living among young Europeans with intellectual disabilities.\n\nDifferent workshops and bigger events (i.e., international conference), together with the involvement of numerous participants from the institutions of this consortium will be ensured. Further, a sensitized community will participate through the social networks and the website itself, in the proposed activities.\n\n\\- Provide digital resources and tools to the partner entities of the exchange to improve lifestyle of young people with intellectual disabilities.\n\nBest Practices to provide high quality, inclusive digital health education with the best educational technology tools and methodology. A website, a mobile app and different electronic guidelines will be delivered.\n\n\\- Analyze the current state of use and acceptance of technologies as support in the management of health in adolescent with intellectual disabilities.",[384,385,386],"Intellectual Disabilities (F70-F79)","Down Syndrome (DS)","Autism Disorder",[388,389,390,36,391,392,393],"Intellectual Disabilities","Physical Activity","Sedentary Behavior","Health Behavior Change","Health Promotion","Lifestyle Intervention","2025-08-02",{"date":396,"type":42},"2025-08-07",{"date":398,"type":42},"2024-01-01",{"date":400,"type":23},"2025-09-01",{"name":48,"class":49},{"id":403,"slug":404,"hasResults":12,"nctId":405,"briefTitle":406,"officialTitle":407,"acronym":4,"eligibilityCriteria":408,"healthyVolunteers":12,"sex":19,"minAge":409,"maxAge":410,"enrollmentInfo":411,"targetDuration":4,"studyType":24,"phases":413,"briefSummary":414,"conditions":415,"keywords":417,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":422,"lastUpdatePostDateStruct":423,"startDateStruct":425,"completionDateStruct":426,"leadSponsor":428,"locationsCount":4},"100594667","effects-of-a-cognitive-engaging-strength-training-program-on-health-physical-condition-and-quality-of-life-in-people-with-alzheimers-disease-100594667","NCT07022431","Effects of a Cognitive-Engaging Strength Training Program on Health, Physical Condition, and Quality of Life in People With Alzheimer's Disease","Effects of a Strength Training Program With High Cognitive Engagement on Health, Physical Condition, and Quality of Life in People With Alzheimer's Disease","Inclusion Criteria:\n\n* Meet the criteria for early AD dementia (GDS 4) (according to the DSM-IV-TR and NINCDS-ADRDA criteria)\n* Have a score between 15 and 20 on the Mini-Mental State Examination scale (Trivedi, 2017), with criteria for moderate cognitive impairment.\n* Maintain a stable pharmacological regimen for at least 30 days prior.\n* Give consent to be evaluated using the cognitive screening tests described in this report.\n* Be available to attend in person weekly at the headquarters where the training will take place in Seville capital.\n\nExclusion Criteria:\n\n* Presence of heart disease or other diseases that lead to a contraindication in the practice of physical activity.\n* Presence of psychiatric illnesses.\n* Having some musculoskeletal pathology or alteration that does not allow the performance of the proposed exercises or proposed conditional evaluations.\n* Having a resting heart rate less than 50 or greater than 100 beats per minute.\n* Having a diagnosed intellectual disability.","65 Years","75 Years",{"count":412,"type":23},34,[26],"The primary objective of this project is to examine the impact of a strength training program with high cognitive demands on cognitive function, motor skills, physical fitness, and quality of life in individuals with Alzheimer's disease and mild cognitive impairment. This randomized controlled trial will involve participants for a total of five months. Initial two weeks will be for cognitive, physical fitness, quality of life, and specific biochemical profile evaluations, along with familiarization sessions with the exercise routine. The experimental group will then undertake a supervised strength training program twice a week for 16 weeks. The final two weeks will involve re-evaluations of all initial assessments. Participants will be randomized into a control group and an intervention group with a minimum of 17 individuals each. Stratification criteria for randomization include physical activity level, number of Alzheimer's disease-related risk factors, extent of brain damage based on MRI biomarkers, and clinical dementia rating scores.",[416],"Alzheimer Disease",[418,419,420,421],"Alzheimer's Disease","Cognitive Function","High Cognitive Demand Exercises","Strength Training","2025-06-06",{"date":424,"type":42},"2025-06-15",{"date":277,"type":23},{"date":427,"type":23},"2026-07",{"name":48,"class":49},{"id":430,"slug":431,"hasResults":12,"nctId":432,"briefTitle":433,"officialTitle":434,"acronym":4,"eligibilityCriteria":435,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":436,"targetDuration":4,"studyType":24,"phases":438,"briefSummary":439,"conditions":440,"keywords":441,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":447,"leadSponsor":449,"locationsCount":96},"100565340","feasibility-study-and-pilot-hybrid-effectiveness-implementation-trial-for-the-universal-prevention-of-maternal-perinatal-mental-disorders-as-normalized-routine-practice-e-perinatal-pilot-100565340","NCT06640907","Feasibility Study and Pilot Hybrid Effectiveness-Implementation Trial for the Universal Prevention of Maternal Perinatal Mental Disorders as Normalized Routine Practice (e-Perinatal Pilot)","Universal Prevention of Maternal Perinatal Mental Disorders and Its Implementation as Normalized Routine Practice (e-Perinatal): Pilot Randomized Control Trial (WP2)","Inclusion criteria for mothers:\n\n* Must receive an invitation to participate from a healthcare professional at one of the participating primary healthcare centers\n* Must be pregnant for at least 16 weeks or have given birth within the last 5 months at the time of enrollment\n* Must be at least 18 years old\n* Must have access to a mobile phone and internet connection\n* Must be able to read, write, and understand Spanish\n* Must have a personal email account\n\nInclusion criteria for partners (or significant others):\n\n* Must receive an invitation to participate from a woman already enrolled in the study\n* Must be at least 18 years old\n* Must have access to a mobile phone and internet connection\n* Must be able to read, write, and understand Spanish\n* Must have a personal email account\n\nExclusion criteria for mothers:\n\n* Meet diagnostic criteria for anxiety or depression, as determined by a structured clinical interview\n* Be on a waiting list or currently receiving psychological or pharmacological treatment for any mental health or substance use condition\n\nExclusion criteria for partners (or significant others):\n\n* There are no exclusion criteria for partners",{"count":437,"type":23},96,[26],"This study is part of the e-Perinatal project, funded by the European Research Council. This research project will follow the first three phases recommended by the Medical Research Council (MRC) framework for the development and evaluation of complex interventions (Skivington et al., 2021).\n\nThe primary aim is to evaluate the feasibility and acceptability of implementing an innovative, personalized mobile health (mHealth) intervention designed for the universal prevention of perinatal mental disorders. Using a pilot, two-arm, cluster-randomized hybrid type 1 clinical trial, the study will assess key implementation outcomes and preliminary effectiveness indicators. The findings will inform the design of a future large clinical trial, intending to evaluate the effectiveness, cost-effectiveness, and implementation of the intervention as part of maternal care.",[29,30],[32,33,34,442,35,36],"Well-being","2025-05-02",{"date":445,"type":42},"2025-05-07",{"date":443,"type":42},{"date":448,"type":23},"2025-12",{"name":48,"class":49},{"id":451,"slug":452,"hasResults":12,"nctId":453,"briefTitle":454,"officialTitle":455,"acronym":4,"eligibilityCriteria":456,"healthyVolunteers":12,"sex":19,"minAge":4,"maxAge":4,"enrollmentInfo":457,"targetDuration":4,"studyType":459,"phases":4,"briefSummary":460,"conditions":461,"keywords":463,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":468,"lastUpdatePostDateStruct":469,"startDateStruct":471,"completionDateStruct":473,"leadSponsor":475,"locationsCount":476},"100587428","drug-drug-intercations-and-direct-acting-antiviral-agents-against-hcv-100587428","NCT06928259","Drug-Drug Intercations and Direct Acting Antiviral Agents Against HCV","Clinical Relevance of Drug-drug Interactions (DDI) With the Currently Used Direct-acting Antiviral Therapy (DAA) Against Hepatitis C Virus (HCV)","Inclusion Criteria:\n\n1. Treatment naive patients who received therapy with GLE\u002FPIB or SOF\u002FVEL between April 1st, 2018, and July 1st, 2023, receiving ≥ 1 comedication or recreational drug.\n2. Attended in a hospital with electronic clinical records allowing access to all clinical visits and prescribed medications, both in all hospitals and in primary care institutions of the corresponding Spanish region during the study period.\n\nExclusion Criteria:\n\nPatients who meet any of the following criteria will be excluded from the study:\n\n1. HCV treatment-experienced patients will be excluded.\n2. Patients without any comedication or recreational drug use\n3. Those who have attended private health care",{"count":458,"type":23},728,"OBSERVATIONAL","Background: Currently used direct-acting antivirals (DAA) share pharmacokinetic pathways with many comedications commonly used in patients with chronic hepatitis C virus (HCV) infection, therefore drug-drug interactions (DDI) might exist. Although extensive (DDI) verification is recommended by most clinical practice guidelines, real-world studies have shown that approximately one-tenth of patients on DAA therapy also take concomitant medication with the potential for significant interactions. Despite the risk of significant DDI when patients are administered DAA and a concomitant medication, to date, there is very little information on whether these interactions translate into changes in the toxicity or efficacy of any involved DAA or comedication in clinical practice. Clarifying this issue is a critical point, as the DDI profile of the currently used DAA is not the same, with SOF\u002FVEL showing a lower risk of significant DDI than GLE\u002FPIB. Thus the objective of this study is to compare the percentage of comedication switch, withdrawal, or dose reduction at treatment initiation and during treatment with GLE\u002FPIB or SOF\u002FVEL.\n\nMethods: The patients will be enrolled from the GEHEP 001\u002FHEPAVIR cohort. \"The HEPAVIR-DAA cohort (NCT02057003)\", includes HIV\u002FHCV-coinfected patients, and \"the GEHEP-MONO cohort (NCT02333292)\", that includes HCV mono-infected individuals, are ongoing prospective multicenter cohorts of patients receiving DAA combinations prescribed in clinical practice, outside clinical trials. Main Study End Point will be the frequency of comedication switch, withdrawal or dose reduction at treatment initiation (index date) and during treatment with GLE\u002FPIB or SOF\u002FVEL.",[462],"HCV Infection",[464,465,466,467],"HCV","SOF\u002FVEL","GLE\u002FPIB","drug-drug interactions","2025-04-07",{"date":470,"type":42},"2025-04-15",{"date":472,"type":23},"2025-04-30",{"date":474,"type":23},"2026-03",{"name":48,"class":49},4,{"id":478,"slug":479,"hasResults":12,"nctId":480,"briefTitle":481,"officialTitle":482,"acronym":4,"eligibilityCriteria":483,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":484,"targetDuration":4,"studyType":24,"phases":485,"briefSummary":486,"conditions":487,"keywords":489,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":492,"lastUpdatePostDateStruct":493,"startDateStruct":495,"completionDateStruct":497,"leadSponsor":499,"locationsCount":476},"100538910","effectiveness-of-noninvasive-phrenic-nerve-neuromodulation-in-shoulder-pain-and-hepatobiliary-visceral-comorbidity-100538910","NCT06296979","Effectiveness of Noninvasive Phrenic Nerve Neuromodulation in Shoulder Pain and Hepatobiliary Visceral Comorbidity.","Effectiveness of Noninvasive Phrenic Nerve Neuromodulation in Subjects With Right Shoulder Pain and Hepatobiliary Visceral Comorbidity.","Inclusion Criteria:\n\n* Over 18 years of age.\n* Subjects presenting right shoulder pain at the time of enrollment in the study.\n* Presentation of a hepatobiliary visceral disorder that may justify the visceral etiology of the pain.\n* That they agree to participate in the project by signing the informed consent form.\n\nExclusion Criteria:\n\n* Patients with chronic pain due to other diseases such as malignant disease.\n* Patients with rheumatic diseases.\n* Cutaneous infection in the area of pain.\n* Disease of neurological, traumatic, oncologic, or infectious origin that rules out the visceral origin of the pain.\n* Uncooperative subject.\n* Severe psychiatric disease.\n* Loss of cognitive capacity.\n* Contraindication to electrotherapy.",{"count":412,"type":23},[26],"Pain, particularly shoulder pain, is a social and economic problem worldwide. Although visceral pathology is not yet taken into account in the diagnosis of these pains, it is likely that on numerous occasions the hepatobiliary visceral condition causes referred pain in the metameric area belonging to the shoulder due to the involvement of the phrenic nerve. Therefore, the aim of this project is to study the response of treatment by neuromodulation of the phrenic nerve for shoulder pain in patients with associated hepatobiliary pathologies, assessing the possible visceral involvement in the symptomatology.",[488],"Shoulder Pain",[490,488,491],"phrenic nerve","Nuromodulation","2025-03-27",{"date":494,"type":42},"2025-04-02",{"date":496,"type":42},"2024-03-20",{"date":498,"type":23},"2026-12-01",{"name":48,"class":49},{"id":501,"slug":502,"hasResults":12,"nctId":503,"briefTitle":504,"officialTitle":505,"acronym":4,"eligibilityCriteria":506,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":507,"targetDuration":4,"studyType":24,"phases":509,"briefSummary":510,"conditions":511,"keywords":514,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":521,"lastUpdatePostDateStruct":522,"startDateStruct":524,"completionDateStruct":525,"leadSponsor":527,"locationsCount":4},"100583148","effects-of-a-multicomponent-training-program-on-health-outcomes-in-patients-with-abdominal-wall-hernia-100583148","NCT06872554","Effects of a Multicomponent Training Program on Health Outcomes in Patients with Abdominal Wall Hernia","Effects of a Pre Surgery Multicomponent Training Program on Strength, Pain, and Quality of Life in Patients with Abdominal Wall Hernias","Inclusion Criteria:\n\n* Patients ≥ 18 years\n* Ventral hernia ≥ 4cm (W2-3 per EHS classification)\n* Signed informed consent\n\nExclusion Criteria:\n\n* Patients \\\u003C18 years\n* Ventral hernia \\\u003C4cm (W1 per EHS classification)\n* Severe physical\u002Fcognitive impairment affecting mobility and daily activities",{"count":508,"type":23},75,[26],"Abdominal wall hernias are among the most prevalent pathologies today, characterized by specific symptoms such as pain, a sensation of tightness in the affected area, and potential gastrointestinal complications. These symptoms negatively impact patients' health and quality of life.\n\nIn other clinical conditions, such as osteoarthritis, sarcopenia, and fibromyalgia, participation in multicomponent training programs (which integrate strength, mobility, and stretching exercises) has been documented to significantly improve quality of life, reduce pain, and optimize patients' functional capacity. Likewise, scientific literature highlights that in the context of injuries requiring surgical intervention, such as anterior cruciate ligament or meniscus tears, patients who underwent prehabilitation programs based on multicomponent training experienced fewer losses in functional and structural aspects, such as strength and muscle mass. These programs also contributed to a reduction in postoperative pain perception.\n\nTherefore, the primary objective of this study is to evaluate the effects of a multicomponent training program on health variables (pain, quality of life, perceived exertion, and recurrence) and functional capacity (trunk isometric strength, grip strength, and lower limb dynamic strength) in patients with abdominal wall hernias. As a secondary objective, the impact of this program on the aforementioned variables after abdominal wall repair surgery will be investigated.",[512,35,513,389],"Abdominal Wall Hernia","Exercise",[515,516,517,518,519,520],"hernia","abdominal wall","exercise intervention","quality of life","pain","incisional hernial","2025-03-06",{"date":523,"type":42},"2025-03-12",{"date":470,"type":23},{"date":526,"type":23},"2025-12-15",{"name":48,"class":49},{"id":529,"slug":530,"hasResults":12,"nctId":531,"briefTitle":532,"officialTitle":533,"acronym":534,"eligibilityCriteria":535,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":536,"enrollmentInfo":537,"targetDuration":4,"studyType":24,"phases":538,"briefSummary":540,"conditions":541,"keywords":543,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":545,"lastUpdatePostDateStruct":546,"startDateStruct":548,"completionDateStruct":550,"leadSponsor":552,"locationsCount":553},"100485789","phase-4-phrenic-nerve-infiltration-in-neck-pain-100485789","NCT05605639","Phrenic Nerve Infiltration in Neck Pain","Phrenic Afferences In Organic and Metabolic Illness: Central Sensitization","PAINOMICS","Inclusion Criteria:\n\n* Over 18 and under 64 years old\n* Patients attending to the physician or physical therapist with a main complaint of neck pain\n* Presentation of any peridiaphragmatic visceral disorder.\n* That the subject agrees to participate in the project by signing the informed consent.\n\nExclusion Criteria:\n\n* Illness of neurological, traumatic, oncological, infectious or rheumatic (fibromyalgia, ankylosing spondylitis...) origin.\n* Uncooperative subject.\n* Severe psychiatric illness.\n* Loss of Cognitive Ability.\n* Contraindication to infiltration of the phrenic nerve.\n* History of head, spinal or upper limb surgery\n* History of infiltration for the neck pain in the previous 3 months\n* History of physical therapy for the neck pain in the previous 30 days","64 Years",{"count":380,"type":23},[539],"PHASE4","Neck pain frequently present comorbidities in peridiaphragmatic organs. The innervation of these organs include the phrenic nerve. It is known that peridiaphragmatic organs trigger referred pain in the neck area. As well, previous studies have shown that visceral disorders increase sensitization in somatic tissues. This study aims to analyze the ability of phrenic nerve infiltration to diminish sensitization and improve neck symptoms in the absence of neurological, traumatic or infectious pathology that justifies the pain, by means of a randomized controlled trial.",[542],"Chronic Neck Pain",[490,544],"anesthesia, local","2024-12-05",{"date":547,"type":42},"2024-12-11",{"date":549,"type":42},"2022-11-17",{"date":551,"type":23},"2025-07",{"name":48,"class":49},2,{"id":555,"slug":556,"hasResults":12,"nctId":557,"briefTitle":558,"officialTitle":559,"acronym":560,"eligibilityCriteria":561,"healthyVolunteers":12,"sex":58,"minAge":562,"maxAge":197,"enrollmentInfo":563,"targetDuration":565,"studyType":459,"phases":4,"briefSummary":566,"conditions":567,"keywords":570,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":575,"lastUpdatePostDateStruct":576,"startDateStruct":578,"completionDateStruct":580,"leadSponsor":581,"locationsCount":553},"100569611","evaluation-of-morphofunctional-and-baropodometric-changes-in-pregnant-women-100569611","NCT06696495","Evaluation of Morphofunctional and Baropodometric Changes in Pregnant Women","Evaluation of Morphofunctional and Baropodometric Changes in the Foot and Ankle of Pregnant Women: Longitudinal Study from the Pregestational Stage to the Postpartum Period","FOOTpreg","Inclusion Criteria:\n\n1. Healthy women between 20 and 35 years old.\n2. If pregnant, they must be in the first trimester of pregnancy (before week 12).\n3. Absence of chronic or acute pathologies that may interfere with the analysis of biomechanical variables (arthritis, vascular or metabolic problems).\n4. Not having had previous foot or ankle surgeries.\n\nExclusion Criteria:\n\n1. Women with multiple pregnancies (twin or multiple pregnancies increase biomechanical variations).\n2. Conditions that affect gait or foot structure (arthritis, neuropathies, or other orthopedic problems).\n3. History of previous foot or ankle injuries that may alter measurements.","20 Years",{"count":564,"type":23},100,"1 Year","Pregnancy causes physiological and biomechanical changes in the female body, such as weight gain and hormonal changes, which can affect the structure and function of the foot and ankle. These adaptations can influence gait, balance and stability. However, the temporal evolution of these changes in the foot and ankle before, during and after pregnancy is not well documented. This study aims to characterize and quantify these changes, as well as their impact on foot function, with the aim of contributing to the prevention and management of podiatric and orthopedic problems in pregnant women.",[568,569],"Pregnancy Related","Foot Diseases",[571,572,573,574],"pregnancy","foot diseases","Postural Balance","Foot Morphology","2024-11-17",{"date":577,"type":42},"2024-11-20",{"date":579,"type":23},"2025-01",{"date":279,"type":23},{"name":48,"class":49},{"id":583,"slug":584,"hasResults":12,"nctId":585,"briefTitle":586,"officialTitle":587,"acronym":588,"eligibilityCriteria":589,"healthyVolunteers":18,"sex":19,"minAge":20,"maxAge":4,"enrollmentInfo":590,"targetDuration":4,"studyType":24,"phases":592,"briefSummary":593,"conditions":594,"keywords":596,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":602,"lastUpdatePostDateStruct":603,"startDateStruct":605,"completionDateStruct":606,"leadSponsor":607,"locationsCount":96},"100569551","effects-of-hrv-biofeedback-interoceptive-training-and-mindfulness-on-stress-in-university-students-and-staff-100569551","NCT06695715","Effects of HRV Biofeedback, Interoceptive Training, and Mindfulness on Stress in University Students and Staff","Effect of Heart Rate Variability Biofeedback, Interoceptive Training, and Mindfulness on Stress Reduction in the University of Seville Academic Community (Faculty, Administrative Staff, and Students)","BIMStress","Inclusion Criteria:\n\n* Members of the University of Seville community over 18 years old (students, teaching staff, and administration and service staff)\n* Be able to attend at least five of the six weeks of the Heart Rate Variability Biofeedback (HRV-BF) and Mindfulness (PEM) training programs\n* Have a smartphone.\n\nExclusion Criteria:\n\n* Members of the University of Seville community who are experiencing severe anxiety or depression; a serious mental illness, such as hypomania or psychotic episodes; recent grief or a major loss; any heart disease; any other serious physical or mental health condition that may affect their ability to participate in the training program.",{"count":591,"type":23},120,[26],"The goal of this clinical trial is to learn if Heart Rate Variability Biofeedback (HRV-BF), Mindfulness programs, and Interoception training can reduce stress, improve well-being, and induce brain changes in university students and staff at the University of Seville. The main questions it aims to answer are:\n\n* Does HRV-BF training reduce stress, improve emotional regulation, and cause measurable brain changes in participants?\n* Does Mindfulness training reduce perceived stress, improve mental health, and lead to changes in brain activity?\n* Does Interoception training enhance emotional self-regulation, reduce stress, and produce changes in brain function?\n* How do the effects on the brain compare between the different types of training (HRV-BF, Mindfulness, and Interoception)?\n\nIf there is a comparison group: Researchers will compare participants who receive HRV-BF, Mindfulness, and Interoception training to a waitlist control group to see if any of these interventions lead to greater reductions in stress, improvement in emotional regulation, or brain activity changes.\n\nParticipants will:\n\n* Complete pre- and post-training assessments to measure stress levels, anxiety, emotional regulation, and brain activity using EEG (electroencephalography).\n* Participate in one of three interventions:\n\nHRV-BF training, where participants learn to use biofeedback to improve heart rate variability and manage stress.\n\nMindfulness-based stress reduction, which involves meditation and mindful awareness techniques to reduce stress and improve mental health.\n\nInteroception training, where participants learn to focus on internal bodily signals (like heartbeat and breath) to improve emotional regulation and manage stress.\n\nEach intervention will last six weeks, and participants will be assessed at the beginning and end of the program. This study aims to determine which intervention is most effective at reducing stress, improving mental health, and producing beneficial changes in brain activity in university community members.",[595,33],"Stress",[595,33,597,598,599,600,601],"Mindfulness","HRV Biofeedback","qEEG","University Students and Staff","Interoception","2024-11-15",{"date":604,"type":42},"2024-11-19",{"date":579,"type":23},{"date":185,"type":23},{"name":48,"class":49},{"id":609,"slug":610,"hasResults":12,"nctId":611,"briefTitle":612,"officialTitle":613,"acronym":614,"eligibilityCriteria":615,"healthyVolunteers":12,"sex":19,"minAge":20,"maxAge":616,"enrollmentInfo":617,"targetDuration":4,"studyType":24,"phases":619,"briefSummary":620,"conditions":621,"keywords":624,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":632,"lastUpdatePostDateStruct":633,"startDateStruct":635,"completionDateStruct":637,"leadSponsor":638,"locationsCount":96},"100567671","effectiveness-of-infiltrations-in-the-treatment-of-plantar-fasciopathy-100567671","NCT06671223","Effectiveness of Infiltrations in the Treatment of Plantar Fasciopathy","Effectiveness of Infiltrations in the Treatment of Plantar Fasciopathy: A Randomized Clinical Study.","INFILTRA-PLANT","Inclusion Criteria:\n\nAge: Participants aged 18 to 50 years. Diagnosis: Confirmed diagnosis of plantar fasciopathy based on clinical evaluation and imaging (if applicable).\n\nDuration of Symptoms: Symptoms persisting for at least 6 weeks prior to enrollment.\n\nPain Level: Reported pain level of at least 4 on the Visual Analog Scale (VAS) at baseline.\n\nAbility to Comply: Participants must be able to follow study protocols and attend follow-up appointments.\n\nInformed Consent: Participants must provide written informed consent to participate in the study.\n\nExclusion Criteria:\n\nOther Foot Pathologies: Presence of other significant foot conditions (e.g., fractures, arthritis, tarsal tunnel syndrome) that could interfere with the study results.\n\nPregnancy or Breastfeeding: Pregnant or breastfeeding individuals will be excluded from the study.\n\nNeurological Disorders: History of significant neurological disorders affecting lower limb function.\n\nSystemic Conditions: Patients with systemic conditions (e.g., diabetes, autoimmune diseases) that could affect healing or response to treatment.\n\nAllergy to Corticosteroids: Known allergy or adverse reaction to corticosteroids or local anesthetics.\n\nPsychiatric Disorders: Individuals with severe psychiatric disorders that may impair their ability to provide informed consent or adhere to the study protocol.","50 Years",{"count":618,"type":23},200,[26],"This clinical study aims to evaluate the effectiveness of infiltrations in the treatment of plantar fasciopathy, a painful condition that affects the sole of the foot and is common in active people. Plantar fasciopathy is caused by inflammation or damage to the plantar fascia, the tissue that connects the heel to the toes. Participants in this study will be randomly assigned to receive one of two treatments: corticosteroid infiltrations or conservative treatment without infiltrations. Infiltrations will be guided by ultrasound to ensure accuracy. The study will evaluate pain reduction and improvement in foot function over a six-month period. The objective of the study is to determine if infiltrations provide a significant improvement compared to other non-invasive treatments. The results will help doctors and patients make informed decisions about the best treatment options for plantar fasciopathy.",[622,623],"Plantar Fasciitis of Both Feet","Plantar Fasciopathy",[625,626,627,628,629,630,631],"plantar fasciitis","fasciopaty","corticosteroid","PRP","hyaluronic acid","infiltrations","treatment","2024-10-31",{"date":634,"type":42},"2024-11-04",{"date":636,"type":23},"2025-06-01",{"date":498,"type":23},{"name":48,"class":49},{"id":640,"slug":641,"hasResults":12,"nctId":642,"briefTitle":643,"officialTitle":644,"acronym":4,"eligibilityCriteria":645,"healthyVolunteers":12,"sex":19,"minAge":234,"maxAge":646,"enrollmentInfo":647,"targetDuration":4,"studyType":24,"phases":648,"briefSummary":649,"conditions":650,"keywords":652,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":660,"lastUpdatePostDateStruct":661,"startDateStruct":663,"completionDateStruct":664,"leadSponsor":666,"locationsCount":96},"100563472","single-button-mobility-platforms-effect-on-reaction-time-and-keystroke-accuracy-in-children-with-cerebral-palsy-100563472","NCT06616610","Single-Button Mobility Platform's Effect on Reaction Time and Keystroke Accuracy in Children with Cerebral Palsy","Single-Button Mobility Platform's Effect on Reaction Time and Keystroke Accuracy in Children with Cerebral Palsy: a Pilot Study","Inclusion Criteria:\n\n* Diagnosed with cerebral palsy\n* Classified as GMFCS level IV or higher, indicating an inability to walk or operate a powered wheelchair.\n* Under 12 years old.\n* Must be affiliated to a center whose facilities guarantee a proper navigation experience\n\nExclusion Criteria:\n\n\\- Inability to act on an actuator (Start button)","12 Years",{"count":476,"type":23},[26],"The goal of this clinical trial is to determine whether the use of a mobility platform can improve response time in children with cerebral palsy.\n\nThe primary question it seeks to answer is: Can the use of a mobility platform enhance cognitive development in children with severe disabilities?\n\nChildren are randomly assigned to two equal-sized groups: the control group, where participants will continue with their standard therapy, and the intervention group, where participants will use the mobility platform. Researchers will compare outcomes between the two groups.\n\nParticipants in the control group will engage in a traditional cause-and-effect therapy, using a video that frequently pauses, requiring them to press an adapted button to continue watching. Participants in the intervention group will use the mobility platform during their sessions. Movement begins when the participant presses the adapted button, and the platform advances, adjusting its direction using sensors to detect obstacles. Once the preset time limit is reached, the platform stops, and the child must press the button again to resume movement. This stop-start process mirrors the cause-and-effect training in the control group.",[651],"Cerebral Palsy Infantile",[653,654,655,656,657,658,659],"Cerebral Palsy","Children","Reaction Time","mobility platform","cognitive development","GMFCS levels IV-V","motor skills","2024-10-10",{"date":662,"type":42},"2024-10-15",{"date":398,"type":42},{"date":665,"type":23},"2025-06",{"name":48,"class":49},{"id":668,"slug":669,"hasResults":12,"nctId":670,"briefTitle":671,"officialTitle":671,"acronym":672,"eligibilityCriteria":673,"healthyVolunteers":12,"sex":19,"minAge":674,"maxAge":235,"enrollmentInfo":675,"targetDuration":4,"studyType":24,"phases":676,"briefSummary":677,"conditions":678,"keywords":680,"overallStatus":87,"whyStopped":4,"lastUpdateSubmitDate":685,"lastUpdatePostDateStruct":686,"startDateStruct":687,"completionDateStruct":689,"leadSponsor":690,"locationsCount":96},"100496789","use-of-biofeedback-and-virtual-reality-as-facilitators-of-emotional-recognition-in-the-treatment-of-aggressive-outbursts-100496789","NCT05748808","Use of Biofeedback and Virtual Reality as Facilitators of Emotional Recognition in the Treatment of Aggressive Outbursts","BReTIA","Inclusion Criteria:\n\n* Previous diagnosis of ADHD, Asperger syndrome or oppositional defiant disorder (ODD) combined with a lack of control of their aggressiveness.\n* Positive impulsivity result obtained with any of the fol- lowing tests: score lower than 25 in CACIA \\[13\\], lower than 50 in CAPI-A \\[14\\], greater than 75 in Stroop \\[15\\] or greater than 115 in WCST \\[16\\].\n* Intermittent outburst episodes (verbal aggression includ- ing both arguments and temper tantrums, and physical aggression towards self or others) with a frequency of once a week in the two months prior to the beginning of the intervention.\n\nExclusion Criteria:\n\n* Participants will be excluded if they report (a) current (past month) psychopharmacotherapy, (b) a history of bipolar or psychotic disorder, or (c) a traumatic head injury with a loss of consciousness in excess of 60 minutes.","10 Years",{"count":380,"type":23},[26],"The methodology will be applied for the treatment of aggressive episodes. Many people show this kind of behavior associated with several psychological disorders like austistic spectrum disorder (ASD). It will be studied the effect of aggressive outbursts on several physiological signals (heart rate (HR), breathing rate (BR), electroencephalography (EEG), etc). The use of those signals in a biofeedback loop could help patients recognize their internal states and avoid imminent aggression. The study want to verify the efficacy of a cognitive therapy that includes biofeedback and virtual reality (VR) and find out the most significant physiological features that are affected by these episodes.",[679],"Passive-Aggressive Personality Disorder",[681,682,683,268,684],"Aggressive episodes","Emotional dysregulation","Physiological signals","Biofeedback","2024-10-07",{"date":660,"type":42},{"date":688,"type":42},"2024-09-01",{"date":400,"type":23},{"name":48,"class":49},{"id":692,"slug":693,"hasResults":12,"nctId":694,"briefTitle":695,"officialTitle":695,"acronym":696,"eligibilityCriteria":697,"healthyVolunteers":18,"sex":19,"minAge":698,"maxAge":699,"enrollmentInfo":700,"targetDuration":701,"studyType":459,"phases":4,"briefSummary":702,"conditions":703,"keywords":707,"overallStatus":38,"whyStopped":4,"lastUpdateSubmitDate":711,"lastUpdatePostDateStruct":712,"startDateStruct":714,"completionDateStruct":715,"leadSponsor":716,"locationsCount":96},"100555721","use-of-thermography-for-the-prevention-and-diagnosis-of-rheumatic-foot-100555721","NCT06515769","Use of Thermography for the Prevention and Diagnosis of Rheumatic Foot","TG-AR","Inclusion Criteria:\n\n* Patients with rheumatoid arthritis of more than 5 years\\' duration\n* Healthy patients without diagnosed systemic disease\n* Patients between 40 and 80 years of age\n\nExclusion Criteria:\n\n* Patients who are pregnant or may become pregnant\n* Patients with degenerative diseases or significant cognitive impairment\n* Patients with rheumatic diseases without a diagnosis of rheumatoid arthritis","40 Years","80 Years",{"count":618,"type":23},"6 Months","The aim of this observational study is to establish normal thermographic parameters in patients with rheumatoid arthritis, in order to prevent and diagnose rheumatic foot using thermography. The main question to be answered is: What are the normal thermographic parameters in rheumatic foot?\n\nIf there is a comparison group: the researchers will compare the thermography of the foot in healthy subjects and in subjects with rheumatoid arthritis to see if there are any alterations in the thermographic image.\n\nPatients who wish to participate in the study will undergo a thermographic study of the foot, which does not entail any risk to their health.",[704,705,706],"Rheumatoid Arthritis","Rheumatoid Arthritis RA","Rheumatic Diseases",[708,704,709,710],"Rheumatic foot","Rheumatic diseases","Thermoghrapy","2024-07-17",{"date":713,"type":42},"2024-07-23",{"date":688,"type":23},{"date":400,"type":23},{"name":48,"class":49},""]