[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Sheffield\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":234},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,8,0,[8,50,82,102,123,145,176,207],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":26,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":46,"locationsCount":49},"100623230","mnd-together-phase-1-100623230",false,"NCT07393932","MND Together: Phase 1","MND Together: Improving Communication and Coordination of Motor Neuron Disease Care","WS1\n\nInclusion Criteria:\n\n* Person with MND, carers, former carers, Health and Social Care Professionals, managers and commissioners\n* Ability to engage in focus group or interview or email interview\n\nExclusion Criteria:\n\n* no exclusion criteria\n\nWS2\n\nInclusion Criteria:\n\n* Person with MND, carers, former carers, Health and Social Care Professionals, managers and commissioners\n* Ability to engage in an observations and interviews\n\nExclusion Criteria:\n\n* no exclusion criteria",true,"ALL","18 Years",{"count":20,"type":21},287,"ESTIMATED","OBSERVATIONAL","This project consists of two workstreams, both of which will be mixed-methods and aim to develop a national UK picture of current care coordination for people with MND, including observations of barriers and facilitators. The studies will explore how care is transferred and communicated across MND specialist services to non-specialist community health settings.\n\nIn workstream 1, the researchers will conduct focus groups with people with MND, Carers, former Carers, Health and Social Care Professionals and managers and commissioners. These focus groups, alongside the analysis of routine data, will create a national picture of MND care and begin a behavioural diagnosis of the barriers and facilitators. In workstream 2, a multi-site ethnography study will be conducted, including observations, interviews, routine data, care plan and document review. This Workstream will observe how care is coordinated between specialist and non-specialist services and continue to explore barriers and facilitators that can not be identified through interviews.",[25],"MND (Motor Neurone DIsease)",[27,28,29,30,31,32,33,34,35,36],"MND","Care coordination","health and social care","multidisciplinary care","community services","Motor Neurone Disease","Neurological conditions","ethnography","Amyotrophic lateral sclerosis (ALS)","Qualitative","NOT_YET_RECRUITING","2026-01-30",{"date":40,"type":41},"2026-02-06","ACTUAL",{"date":43,"type":21},"2026-02",{"date":45,"type":21},"2027-02",{"name":47,"class":48},"University of Sheffield","OTHER",1,{"id":51,"slug":52,"hasResults":11,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":4,"eligibilityCriteria":56,"healthyVolunteers":11,"sex":17,"minAge":57,"maxAge":4,"enrollmentInfo":58,"targetDuration":4,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":67,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":76,"completionDateStruct":78,"leadSponsor":80,"locationsCount":81},"100578044","effectiveness-of-cat-gsh-for-returning-patients-100578044","NCT06806176","Effectiveness of CAT-GSH for Returning Patients","Effectiveness and Acceptability of Cognitive Analytic Therapy Guided Self-help (CAT-GSH) for Anxiety and Depression for Returning Patients in NHS Talking Therapies Services","Inclusion Criteria:\n\n* Previously received CBT-GSH at same participating NHS Talking Therapies service\n* Presenting with anxiety or depression\n* Deemed suitable for step 2 low-intensity therapy, through assessment by a qualified PWP\n\nExclusion Criteria:\n\n* Previously received high-intensity therapy since receiving CBT-GSH\n* The previous treatment episode was in another NHS Talking Therapies service.\n* Not fluent in English\n\nIndividuals who are not fluent in English will be excluded from the study due to not having translated CAT-GSH workbooks available and limited funding to translate any workbooks.","16 Years",{"count":59,"type":21},100,"INTERVENTIONAL",[62],"NA","The goal of this clinical trial is to learn if cognitive analytic therapy-guided self-help (CAT-GSH) is comparable to cognitive behavioural therapy-guided self-help (CBT-GSH) in terms of whether it is effective and acceptable for people with anxiety or low mood, who are returning to NHS Talking Therapy services for further treatment. The main questions it aims to answer are:\n\n* Does CAT-GSH work well and feel acceptable for people coming back to the Talking Therapies service, compared to CBT-GSH, when taking their characteristics (like age) into account\n* Does CAT-GSH work well and feel acceptable for people coming back to the Talking Therapies service, compared to those using CBT-GSH for the first time, when taking their characteristics (like age) into account?\n\nParticipants will:\n\n* Choose their preferred treatment\n* Complete 6 sessions of either CAT-GSH or CBT-GSH\n* Sessions will be weekly or bi-weekly\n* Complete routine outcome measures before, during and at the end of therapy",[65,66],"Anxiety","Depression",[68,69,70,71,65,66],"Cognitive analytic therapy (CAT)","Guided self-help","NHS Talking Therapies","returning patients","RECRUITING","2025-09-29",{"date":75,"type":41},"2025-10-03",{"date":77,"type":41},"2025-07-30",{"date":79,"type":21},"2025-12",{"name":47,"class":48},2,{"id":83,"slug":84,"hasResults":11,"nctId":85,"briefTitle":86,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":11,"sex":17,"minAge":4,"maxAge":4,"enrollmentInfo":89,"targetDuration":91,"studyType":22,"phases":4,"briefSummary":92,"conditions":93,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":49},"100603158","telehealth-in-mnd-research-tim-r-a-research-database-for-mnd-100603158","NCT07132879","Telehealth in MND-Research (TIM-R): A Research Database for MND","TIM-R","Inclusion Criteria:\n\n* People living with MND\n* Living in the UK",{"count":90,"type":21},1000,"50 Years","The aim of this study is to implement the Telehealth in MND system as a research database allowing people with MND to take part in research and provide data remotely (TiM-Research).\n\nTiM-Research is an online platform that helps people with MND in the UK take part in research. It brings MND research studies together in one place, making it quick and easy to learn about opportunities to get involved.\n\nWhat's involved? Participants will receive information about a wide range of research studies that they can sign up for. This could include filling out questionnaires that help researchers understand how MND progresses, providing biosamples (e.g. saliva), or taking part in interviews and focus groups about their experiences. Participants can choose which studies they want to take part in. Participants will also receive updates on research results from the UK MND Research Institute.\n\nWho can take part? People who live with MND and who are based in the UK can sign up for TiM-Research. To join, participants need a computer, phone, or tablet with an internet connection. A family member or carer can help. Participants' information will be kept secure and confidential.\n\nHow do participants sign up? Visit the website to find out more or sign up. www.bit.ly\u002Fukmndri-Tim-R.",[25],"2025-08-12",{"date":96,"type":41},"2025-08-20",{"date":98,"type":41},"2024-12-14",{"date":100,"type":21},"2074-12-14",{"name":47,"class":48},{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":11,"sex":17,"minAge":108,"maxAge":109,"enrollmentInfo":110,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":112,"conditions":113,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":118,"completionDateStruct":120,"leadSponsor":122,"locationsCount":49},"100596712","hypogonadotrophic-hypogonadism-in-genetic-neurodevelopmental-conditions-100596712","NCT07049042","Hypogonadotrophic Hypogonadism in Genetic Neurodevelopmental Conditions","Inclusion Criteria:\n\nPathogenic SNV or CNV in neurodevelopmental disorders gene of interest parent or carer consents to study\n\nExclusion Criteria:\n\nparent or carer does not consent to study","0 Years","99 Years",{"count":111,"type":21},50,"Hypogonadism is the medical name for a condition in which levels of the hormones which control sexual development are lower than normal. There are dozens of different causes of hypogonadism. Many people with hypogonadism have a change in a gene. There are many genes that give instructions for the hormones important for sexual development. Changes in one of these genes that stops the gene from working, can cause hypogonadism. In some of these medical conditions, there are additional features such as learning problems. In this study we will search databases to find all the genetic conditions that can be associated with hypogonadism. We will ask a number of people with changes in certain genes, identified from our search, to come to our research clinic. We will ask them about their health and examine them for signs of hypogonadism. For some, we will take blood samples to test for hypogonadism. This project will help us understand how common hypogonadism is, in people with these genetic changes, which will help with their treatment.",[114],"Genetic Neurodevelopmental Disorders","2025-06-24",{"date":117,"type":41},"2025-07-03",{"date":119,"type":41},"2025-01-08",{"date":121,"type":21},"2029-05-01",{"name":47,"class":48},{"id":124,"slug":125,"hasResults":11,"nctId":126,"briefTitle":127,"officialTitle":128,"acronym":4,"eligibilityCriteria":129,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":130,"enrollmentInfo":131,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":133,"conditions":134,"keywords":4,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":137,"lastUpdatePostDateStruct":138,"startDateStruct":140,"completionDateStruct":142,"leadSponsor":144,"locationsCount":81},"100555188","the-clear-conversations-project-100555188","NCT06508840","The Clear Conversations Project","Clear Conversations: Evaluating a Verbal Health Literacy Intervention in Derbyshire","Inclusion Criteria:\n\n* • Public Health Intervention Advisors delivering the tier 2 weight management programme across Derbyshire.\n\n  * Physiotherapists and specialist nurses involved in the assessment of patients and delivery of the six week DCHS NHS pulmonary rehabilitation programme.\n  * Adults aged 18 or over who start the rolling 12 week tier two weight management programme during the intervention period.\n  * Adults aged 18 or over, with Chronic Obstructive Pulmonary Disease, who are being assessed for and undertaking the six week pulmonary rehabilitation programme during the study intervention period.\n  * For the staff questionnaire only - Healthcare staff from other services that attend Verbal Health Literacy training, during the study period in 2024, will also be eligible\n\nExclusion Criteria:\n\n* • Service users attending the two service programmes outside of the data collection period.\n\n  * Other pulmonary rehabilitation staff. i.e. staff who are not physiotherapists or specialist nurses.","90 Years",{"count":132,"type":21},400,"Understanding health information can be difficult. This means some people struggle to know how to manage their health. Also, people may not know what health services to use or when to use them. This can lead to poorer health.\n\nIt is therefore important health workers can communicate information clearly. This is so people using health services can understand it and know what to do. Having clear conversations with service users could help them to improve their health. More research is needed into this area. This is so we can understand and improve health conversations.\n\nIn this research project health workers will be provided with training. The training will teach them ways to improve their communication skills. Health workers will also receive support from a Health Literacy Officer. The Investigators want to see if this can improve service user outcomes and reduce health inequalities.\n\nThe investigators will ask health workers and service users from a Local Authority and an NHS service to take part. Service users will attend the health programmes as normal. Staff who have and have not received the training will deliver the programmes.\n\nThe investigators will ask service users to complete questionnaires. The investigators will also collect service user data from the programmes. This data will be collected before and after they attend. The investigators will compare this data with the previous year.\n\nThe investigators will observe health workers delivering the programmes. The investigators will use a check list to see how they use the skills they have learnt. The investigators will ask health workers to complete a questionnaire before and after they attend the training. The investigators will run focus groups with the health workers six months later. The investigators want to understand if the training was useful. The investigators also want to know if the health workers are using the skills they learnt in their practice.",[135,136],"COPD","Weight Loss","2025-03-31",{"date":139,"type":41},"2025-04-01",{"date":141,"type":41},"2024-07-01",{"date":143,"type":21},"2025-06-30",{"name":47,"class":48},{"id":146,"slug":147,"hasResults":11,"nctId":148,"briefTitle":149,"officialTitle":150,"acronym":4,"eligibilityCriteria":151,"healthyVolunteers":16,"sex":17,"minAge":152,"maxAge":4,"enrollmentInfo":153,"targetDuration":4,"studyType":60,"phases":155,"briefSummary":156,"conditions":157,"keywords":162,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":168,"lastUpdatePostDateStruct":169,"startDateStruct":171,"completionDateStruct":173,"leadSponsor":175,"locationsCount":49},"100542678","time-and-cost-implications-of-intraoral-scans-vs-alginate-impressions-100542678","NCT06345989","Time and Cost-implications of Intraoral Scans Vs Alginate Impressions","Time and Cost-implications of Intraoral Scans Vs Alginate Impressions: a Randomised Controlled Trial","Inclusion Criteria:\n\n* Orthodontic patients aged 9 years and above requiring study models, having attended the orthodontic department at Nottingham University Hospitals for a new patient assessment.\n\nExclusion Criteria:\n\n* Patients who will not be undergoing orthodontic treatment in secondary care (referral back to primary care).\n* Patients who refuse to consent to inclusion in the trial.\n* Patients with contraindications to either impression method (e.g., severe gag reflex, claustrophobia, medical history that would preclude the taking of dental impressions).\n* Patients with severe dental anxiety.\n* Patients with cleft lip and\u002For palate.","9 Years",{"count":154,"type":21},68,[62],"BACKGROUND: Alginate impressions have long been a staple in orthodontics, but with recent technological advancements, digital impressions via intraoral scans are gaining increasing popularity. While much research has focused on patient preference and the accuracy of these techniques, there is a notable gap in the literature regarding chair side time and associated costs. Existing studies on chair side time comparisons between alginate impressions and intraoral scanning yield inconsistent results, underscoring the need for further investigation. This study aimed to evaluate the chair side time and cost implications of intraoral scanning and alginate impressions.\n\nOBJECTIVES: The primary objective is to compare the chair side time taken for alginate impressions and intraoral scanning of orthodontic patients aged 9 years and over in an orthodontic department at a district general hospital. The secondary objective is to evaluate the costs associated with alginate impressions and intraoral scanning of orthodontic patients described above.\n\nDESIGN, SETTING AND PARTICIPANTS: A prospective, single-centre, parallel-arm randomised controlled trial (1:1 allocation) to be undertaken in a district general hospital. Sixty-eight orthodontic patients aged nine and above, requiring study models, will be recruited during new patient appointments at the Orthodontic Department at Queen's Medical Centre, Nottingham. Patients will be randomly assigned to either the intraoral scan or alginate impression group, with chair side time recorded for each procedure, including retakes. The IOS group will use the 3Shape TRIOS scanner, while the alginate group will follow standard procedures. The costs of each technique will be calculated following the procedure. Ethical approval was obtained from a Health Research Authority Research Ethics Committee.\n\nOUTCOMES: N\u002FA\n\nCONCLUSIONS: N\u002FA",[158,159,160,161],"Alginate Impression","Intraoral Scanner","Time","Cost",[163,164,165,166,167],"Orthodontics","Alginate","Impression","Intraoral","Scanner","2025-02-28",{"date":170,"type":41},"2025-03-05",{"date":172,"type":21},"2025-03",{"date":174,"type":21},"2026-03",{"name":47,"class":48},{"id":177,"slug":178,"hasResults":11,"nctId":179,"briefTitle":180,"officialTitle":181,"acronym":182,"eligibilityCriteria":183,"healthyVolunteers":16,"sex":17,"minAge":184,"maxAge":185,"enrollmentInfo":186,"targetDuration":188,"studyType":22,"phases":4,"briefSummary":189,"conditions":190,"keywords":196,"overallStatus":72,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":200,"startDateStruct":202,"completionDateStruct":204,"leadSponsor":206,"locationsCount":49},"100429936","transcriptomic-responses-for-the-identification-of-pathogens-100429936","NCT04878549","Transcriptomic Responses for the Identification of Pathogens","A Multisite Evaluation of Functional Genomic Signatures for the Improved Diagnosis of Acute Undifferentiated Febrile Infections","TRiP","FEBRILE ADULTS- INCLUSION CRITERIA\n\n* Age greater than or equal to 15 years and less than or equal to 65 years\n* Participant is willing and they and\u002For an appropriate guardian\u002Frelative\u002Frepresentative is able to give informed consent for participation in the study and a follow-up (telephone) discussion at 14 days\n* And either:\n\n  1. Febrile illness without localising features (see 'exclusion criteria' and 'screening' sections) where fever is defined as:\n\n     * documented tympanic\u002Frectal temperature of ≥ 38°C or an axillary\u002Foral temperature of ≥ 37.8°C, or a reported fever within the last 24 hours and\n     * Reported duration of fever 3-14 days or\n  2. Recently confirmed blood culture indicating enteric fever (confirmed within the previous 5 days)\n* They may have had recent exposure to antimicrobials.\n\nFEBRILE ADULTS- EXCLUSION CRITERIA\n\n* The participant may not enter the study if ANY of the following apply:\n* Unable to provide informed consent and no next of kin is willing and able to provide informed consent.\n* For patients with febrile illness (included in (1) above): Any history or clinical suspicion of:\n\n  * Rheumatological or connective tissue disorder (e.g. Rheumatoid arthritis)\n  * Autoimmune condition (e.g. Autoimmune Hepatitis)\n  * Malignancy\n  * Active treatment with immunomodulating medications, or for tuberculosis (pulmonary or extrapulmonary) or any other chronic infection.\n* Pregnancy (breast feeding mothers will NOT be excluded)\n* No hospitalisation for more than 48 hours in the last 4 weeks\n* Vaccination within 4 weeks prior to current admission\n* Localising signs or symptoms of infection sufficient to diagnose the likely cause of acute febrile illness and thus prevent it from being 'undifferentiated.'\n\nCONTROLS- INCLUSION CRITERIA\n\n* Participant is willing and they are (and in 15-18 year olds, a guardian is) able to give informed consent for participation in the study\n* Age greater than or equal to 15 years and less than or equal to 65 years\n* They live outside of the normal\u002Flocal catchment area for each hospital site\n* Afebrile (as defined by no reported fever and temperature ≤ 38°C or an axillary\u002Foral temperature of ≤ 37.8°C).\n\nCONTROLS- EXCLUSION CRITERIA\n\n* The participant may not enter the study if ANY of the following apply:\n* Unable to provide informed consent and no next of kin (or parent\u002Fguardian in the case of a minor) is willing and able to provide informed consent.\n* Current treatment for or prior history, or clinical suspicion of:\n\n  * Rheumatological or connective tissue disorder\n  * Autoimmune condition\n  * Malignancy\n  * Active treatment for tuberculosis (pulmonary or extrapulmonary) or clinical suspicion of active tuberculosis. Previous completed treatment is not a reason for exclusion.\n  * Active treatment with immunomodulating medications or any other chronic infection.\n* Pregnant (breast feeding mothers will NOT be excluded)\n* Hospitalisation within 4 weeks of recruitment\n* Vaccination within 4 weeks prior to recruitment\n* Antimicrobial use within 4 weeks of recruitment\n* Participant reports feeling more unwell than usual on the day of enrolment.\n\nEXPLORATORY AIMS- PAEDIATRIC CRITERIA; INCLUSION CRITERIA\n\n* Age greater than or equal to 2 years and less than 15 years\n* As above for adult participants.\n\nEXPLORATORY AIMS- PAEDIATRIC CRITERIA; EXCLUSION CRITERIA\n\n* Parent\u002Fguardian is unwilling, and\u002For patient aged 8 to 14 years is unwilling to assent to provide informed consent.\n* As above for adult participants.","2 Years","65 Years",{"count":187,"type":21},2000,"14 Days","Acute undifferentiated febrile infection (AUFI) is a common presenting syndrome in low-resource settings and better diagnostics are urgently needed to improve patient management and guide disease prevention interventions. Assessment of the host gene expression response to infection in endemic populations has demonstrated significant promise as a new approach to identifying patients with enteric fever and for potential in differentiating between other causes of AUFI. Signatures identified through new data analytic techniques could be developed into a point-of-care test for use in endemic settings.\n\nIn this multisite diagnostic evaluation study we will collect prospective clinical, laboratory and diagnostic data from two endemic settings to evaluate host gene expression signatures for detecting enteric fever and for determining the cause of AUFI in LMIC settings.",[191,192,193,194,195],"Enteric Fever","Acute Febrile Illness","Typhoid","Paratyphoid Fever","Fever",[197,198],"Gene Expression Profiling","RNA-Seq","2025-02-26",{"date":201,"type":41},"2025-03-03",{"date":203,"type":41},"2022-05-02",{"date":205,"type":21},"2025-06",{"name":47,"class":48},{"id":208,"slug":209,"hasResults":11,"nctId":210,"briefTitle":211,"officialTitle":212,"acronym":4,"eligibilityCriteria":213,"healthyVolunteers":11,"sex":17,"minAge":91,"maxAge":4,"enrollmentInfo":214,"targetDuration":216,"studyType":22,"phases":4,"briefSummary":217,"conditions":218,"keywords":220,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":226,"lastUpdatePostDateStruct":227,"startDateStruct":229,"completionDateStruct":231,"leadSponsor":233,"locationsCount":49},"100564380","unlock-the-secrets-of-ageing-brains-through-p300-brain-computer-interface-games-100564380","NCT06628427","Unlock the Secrets of Ageing Brains Through P300 Brain-computer Interface Games","Effects of Different Parameter Settings on the Classification Accuracy of P300-BCI Speller in Elderly Adults with and Without Mild Cognitive Impairments","Inclusion Criteria:\n\n1. Diagnosed with mild cognitive impairments (MCI) or mild dementia\n2. Normal or corrected-to-normal vision\n3. Can maintain sitting with or without support for around 60 minutes continuously\n4. Cognitive and language abilities to understand and participate in the study protocol and able to give consent and understand instructions\n\nExclusion Criteria:\n\n1. Severe cognitive impairment that would interfere with their ability to comply with the experimental protocol or provide informed consent\n2. Pre-existing severe systemic disorders like active cancer, end-stage pulmonary or cardiovascular disease, psychiatric illness including severe alcohol or drug abuse\n3. Past history of epilepsy- with seizures in last 12 months\n4. History of photosensitive epilepsy.\n5. Allergy to latex",{"count":215,"type":21},15,"3 Months","The study will investigate the use of Electroencephalography (EEG) in understanding mild cognitive impairment (MCI). EEG is commonly used in everyday clinical practice for the assessment of a wide range of neurological disorders. It records the brains spontaneous electrical signals and offers a non-invasive means of visually evaluating brain signals. By analysing these signals, we aim to uncover invaluable insights into cognitive impairments and the ageing brains cognitive processes.",[219],"Mild Cognitive Impairment (MCI)",[221,222,223,224,225],"Brain-computer Interface","Mild Cognitive Impairment","EEG","P300","Elderly","2024-10-02",{"date":228,"type":41},"2024-10-08",{"date":230,"type":21},"2024-10-15",{"date":232,"type":21},"2025-07-14",{"name":47,"class":48},""]