[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Social Sciences and Humanities, Warsaw\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":158},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,5,0,[8,47,80,102,127],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":30,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":35,"lastUpdatePostDateStruct":36,"startDateStruct":39,"completionDateStruct":41,"leadSponsor":43,"locationsCount":46},"100636440","optimization-of-late-imagery-rescripting-research-using-generative-artificial-intelligence-100636440",false,"NCT07565714","Optimization of Late Imagery Rescripting Research Using Generative Artificial Intelligence","ImRs_LLM_DeanG","Inclusion Criteria:\n\n* Age 18-35\n* Score ≥ 8 on GAD-7 (Plummer et al., 2016)\n* Ability to recall at least two childhood memories involving parental criticism\n\nExclusion Criteria:\n\n* History of prolonged physical or sexual abuse\n* Current psychotherapy or psychopharmacology\n* PTSD diagnosis (DSM-5 screening)\n* Substance abuse (TAPS tool)","ALL","18 Years","35 Years",{"count":20,"type":21},40,"ESTIMATED","INTERVENTIONAL",[24],"NA","The aim of the study is to examine the effect of imagery rescripting (ImRs) in the context of utilizing large language models (LLMs). Intervention will involve the prior presentation of the most aversive fragment of the memory, the so-called 'hotspot.' This intervention will allow for the replication of the effect described by Dibbets and Arntz (2016), according to which the prior activation of the most emotional element of a memory enhances the effectiveness of ImRs.\n\nThe study is also significant due to another ongoing study in which a substantial number of participants have already been examined; however, due to the exhaustion of funds, it was not possible to utilize the remainder of the recruited sample. Investigating an additional condition will allow for a more complete utilization of the available participant pool and significantly increase the project's scientific value by comparing the traditional ImRs mechanism with its AI-generated version.",[27,28,29],"Generalized Anxiety","Fear of Failure","Rumination",[28,31,27,32,33],"Intrusive Autobiographical Memories","Imagery Rescripting","AI","RECRUITING","2026-05-03",{"date":37,"type":38},"2026-05-07","ACTUAL",{"date":40,"type":21},"2026-04",{"date":42,"type":21},"2026-07",{"name":44,"class":45},"University of Social Sciences and Humanities, Warsaw","OTHER",2,{"id":48,"slug":49,"hasResults":11,"nctId":50,"briefTitle":51,"officialTitle":52,"acronym":4,"eligibilityCriteria":53,"healthyVolunteers":54,"sex":16,"minAge":55,"maxAge":56,"enrollmentInfo":57,"targetDuration":4,"studyType":22,"phases":59,"briefSummary":60,"conditions":61,"keywords":66,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":72,"lastUpdatePostDateStruct":73,"startDateStruct":75,"completionDateStruct":77,"leadSponsor":79,"locationsCount":46},"100625975","effects-of-darkness-retreat-a-pilot-study-100625975","NCT07429617","Effects of Darkness Retreat: a Pilot Study","Effect of Darkness Retreat on Worry and Rumination in a Non-clinical Population: a Pilot Study","Participants will be recruited from university\u002Fpostgraduate students through a two-stage process.\n\nStage I. Individuals expressing interest in participation will be asked to confirm that they are not currently engaged in psychotherapy or coaching, are not taking psychotropic medication, and are in generally good physical health. The following individuals will be excluded from the study: those diagnosed with an acute or chronic somatic illness (e.g., cardiovascular disease); psychiatric or neurological disorders (e.g., depression, addiction, bipolar disorder, schizophrenia, epilepsy, stroke, severe brain injury, Parkinson's disease, Alzheimer's disease or other forms of dementia); those exhibiting active suicidal tendencies with a plan or intent; those taking psychotropic medication; engaged in psychotherapy or coaching; and pregnant individuals.\n\nPreliminary verification of these criteria will be carried out using a screening questionnaire containing demographic questions and items regarding psychotherapy\u002Fcoaching, use of psychoactive medication, somatic health, suicidal tendencies, pregnancy, and confirmation of a history of diagnoses in the categories of psychotic disorders, eating disorders, obsessive-compulsive disorder, substance use disorders, bipolar disorder, along with the following questionnaires:\n\nPSWQ: Inclusion criteria based on the PSWQ (Penn State Worry Questionnaire, range 16-80, higher scores indicating worse functioning):\n\nParticipants must obtain a total score between 40 and 80. (40-59 = moderate level of worry\u002Fanxiety) (60-80 = high level of worry\u002Fanxiety)\n\nIn cases where participants fall within the high range, if clinical levels of worry are identified during the clinical interview, they will be excluded from participation.\n\nPAtient Health Questionnaire-9 (PHQ-9, range 0-27, higher scores indicating worse functioning): Individuals scoring above 10 will be considered at elevated risk for depression, and those scoring 20 or higher will not be invited to the clinical interview.\n\nGeneralized Anxiety Disorder-7 (GAD-7, range 0-21, higher scores indicating worse functioning): Individuals scoring 7 or higher will be classified as having elevated generalized anxiety symptoms, and those scoring 15 or higher will be excluded from further participation.\n\nAlcohol Use Disorders Identification Test (AUDIT, range 0-40, higher scores indicating worse functioning): Individuals scoring above 8 will be considered at elevated risk for problematic drinking, and those scoring 22 or higher will not be invited to the clinical interview.\n\nDrug Use Disorders Identification Test (DUDIT, range 0-44, higher scores indicating worse functioning): Individuals scoring above 4 will be classified as at elevated risk for substance use, and those scoring 7 or higher will be excluded.\n\nThe questionnaire will also include the following measures, which will not be used for automatic exclusion but will indicate the need for further evaluation during the clinical interview if the following thresholds are met:\n\nDSM-5 - Panic Disorder (range 0-40, higher scores indicating worse functioning): score ≥ 26 DSM-5 - Social Anxiety Disorder (range 0-40, higher scores indicating worse functioning): score ≥ 26 DSM-5 - Post-Traumatic Stress Disorder (range 0-44, higher scores indicating worse functioning): score \\> 22\n\nOnly individuals who are not excluded based on the above criteria will be invited to the next stage.\n\nStage II. Candidates meeting the preliminary criteria will be invited to an online clinical interview with a psychologist. Approximately one week before the scheduled interview, participants will receive via email a link to the Personality Beliefs Questionnaire (PBQ; Zawadzki et al., 2017), that would help in a more in-depth assessment of psychological functioning during the actual meeting. In order to exclude clinical cases, the psychologist will use the structured clinical interview M.I.N.I. (Mini International Neuropsychiatric Interview)\n\nParticipants who complete the psychological interview-regardless of their final qualification for the study-will receive a compensation of approximately 200 ZŁ in shopping vouchers (50EUR).",true,"30 Years","50 Years",{"count":58,"type":21},30,[24],"The primary goal of this pilot study is to test the feasibility and safety of a research protocol for a voluntary darkness retreat.\n\nThe study will also allow for a preliminary examination of the psychological effects of the retreat. The investigators will investigate whether participants experience changes in their well-being and ruminative style, whether these changes persist over time, and if these effects are moderated by individual characteristics such as readiness for change or subjective evaluation of the experience as well as frequency of participants' monitoring.\n\nParticipants will be randomly assigned to one of two experimental groups, both of which will spend 3 days and 3 nights in seclusion. These groups will differ only in the frequency of psychological monitoring during the retreat, allowing us to compare the effectiveness and safety of each protocol.",[62,63,64,65],"Study Protocol Feasibility","Non Clinical Anxiety","Non Clinical Worry","Non Clinical Rumination",[67,68,69,70,71],"sensory deprivation","darkness retreat","protocol feasibility","Anxiety","Mindfulness","2026-02-19",{"date":74,"type":38},"2026-02-24",{"date":76,"type":38},"2025-10-16",{"date":78,"type":21},"2026-11-01",{"name":44,"class":45},{"id":81,"slug":82,"hasResults":11,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":86,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":87,"targetDuration":4,"studyType":22,"phases":89,"briefSummary":90,"conditions":91,"keywords":92,"overallStatus":34,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":101},"100607527","optimization-of-imagery-rescripting-research-using-generative-artificial-intelligence-100607527","NCT07189715","Optimization of Imagery Rescripting Research Using Generative Artificial Intelligence","A Randomized Controlled Pilot Study on AI-Based Imagery Rescripting for Childhood Criticism Memories","FRBN",{"count":88,"type":21},80,[24],"This pilot randomized controlled trial will investigate the feasibility and effectiveness of using generative artificial intelligence to create personalized therapeutic scripts for imagery rescripting (ImRs). Eighty participants will listen to autobiographical scenarios based on their own memories of childhood criticism and neutral events. The scenarios will be generated by the Gemini large language model and reviewed by trained experimenters. On Day 1, all participants will be exposed to both critical and neutral scenarios and randomly assigned to either an experimental group receiving an ImRs intervention or a control group receiving no therapeutic modification. Skin conductance and subjective emotional ratings will be collected during the session, with follow-up questionnaires administered one week later. In addition, cognitive-behavioral therapists will evaluate the quality of the generated scripts. The study aims to assess emotional and physiological responses to AI-generated content, compare outcomes between groups, and explore the potential of large language models in scalable psychological interventions.",[27,28,29],[28,31,27,32,33],"2025-09-15",{"date":95,"type":38},"2025-09-24",{"date":97,"type":38},"2025-06-01",{"date":99,"type":21},"2025-12-31",{"name":44,"class":45},1,{"id":103,"slug":104,"hasResults":11,"nctId":105,"briefTitle":106,"officialTitle":107,"acronym":4,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":4},"100559942","rct-protocol-for-overthinking-a-mobile-emi-for-reducing-experiential-avoidance-100559942","NCT06570694","RCT Protocol for 'OverThinking': A Mobile EMI for Reducing Experiential Avoidance","A Mobile Ecological Momentary Intervention for Reducing Experiential Avoidance in the Context of Rumination: Protocol for a Randomised-Controlled Trial","Inclusion Criteria:\n\n\\- Self-reporting problems with repetitive negative thinking.\n\nExclusion Criteria:\n\n* Aged below 18 years at the commencement of the trial.\n* Currently in receipt of any form of psychotherapy.\n* Currently in receipt of any form of psychiatric medication.\n\nNote: Participants who hold a psychiatric diagnosis will not be excluded from the trial provided they meet the inclusion criterion and do not meet any of the exclusion criteria listed above.",{"count":110,"type":21},60,[24],"The goal of this trial is to examine whether a mobile app intervention for rumination can modify a maladaptive feature of repetitive negative thinking (RNT) - this is understood by the link between daily RNT and well-being, depressive and anxiety symptoms.\n\nThe main questions it aims to answer are:\n\n1. If the intervention can modify the maladaptive feature of repetitive negative thinking - the investigators anticipate the link between daily rumination and maladaptive outcomes (poorer wellbeing, higher depressive\u002Fanxious symptoms) will be weaker in the intervention groups.\n2. By examining (1) above, to confirm the role played by avoidance in repetitive negative thinking.\n3. By splitting the intervention condition into two groups (one receiving concurrent support from a therapist, one not), to evaluate if interventions such as these might be enhanced by therapist support.\n4. To examine if the impact of the intervention on depressive and anxious symptoms might be mediated by changes in beliefs regarding emotions (e.g. the valuation of negative emotions).\n\nResearchers will compare across four groups to examine the above effects:\n\n(1) intervention condition (therapist support); (2) intervention condition (no therapist support); (3) Partial intervention (daily sampling and emotion valuation questions); (4) Control group (only daily sampling questions).\n\nParticipants will:\n\n* Be requested to participate in a four-week intervention, providing daily assessments of depressive and anxiety symptoms, affect, repetitive negative thinking, and rumination outcomes.\n* Use a mobile application during the intervention period, which has been designed by the research team (intervention groups), or provide daily assessment scores only (control groups).\n* Be assessed at pre-intervention (all groups), post-intervention (all groups), 1-month follow-up (all groups), and 3-month follow-up (intervention groups only).",[114,70,29],"Depression",[29,116,114,70,117],"Experiential Avoidance","Ecological momentary intervention","NOT_YET_RECRUITING","2025-04-29",{"date":121,"type":38},"2025-05-02",{"date":123,"type":21},"2025-05-01",{"date":125,"type":21},"2025-07-30",{"name":44,"class":45},{"id":128,"slug":129,"hasResults":11,"nctId":130,"briefTitle":131,"officialTitle":132,"acronym":4,"eligibilityCriteria":133,"healthyVolunteers":54,"sex":16,"minAge":17,"maxAge":55,"enrollmentInfo":134,"targetDuration":4,"studyType":22,"phases":136,"briefSummary":137,"conditions":138,"keywords":143,"overallStatus":118,"whyStopped":4,"lastUpdateSubmitDate":150,"lastUpdatePostDateStruct":151,"startDateStruct":153,"completionDateStruct":155,"leadSponsor":157,"locationsCount":101},"100588714","meta-self-efficacy-internet-intervention-to-improve-work-self-efficacy-and-occupational-well-being-in-young-employees-100588714","NCT06944990","Meta Self-efficacy Internet Intervention to Improve Work Self-efficacy and Occupational Well-being in Young Employees","Meta Self-efficacy Intervention to Improve Work Self-efficacy and Occupational Well-being in Young Employees: Internet Intervention Co-creation and a Randomized Controlled Trial","Inclusion Criteria:\n\n* must be between 18 and 30 years old\n* must be empolyed (working at least 20 h \u002F week, for at least the prior two months, regardless of the type of contract)\n\nExclusion Criteria:\n\n* none",{"count":135,"type":21},600,[24],"This randomized controlled trial aims to test whether enhancing meta self-efficacy through a self-guided internet intervention improves young employees' work self-efficacy and occupational well-being. The trial will evaluate primary (work self-efficacy) and secondary (three dimensions of occupational well-being) outcomes. It is hypothesized that boosting meta self-efficacy will lead to improvements in outcomes, with effects assessed immediately after the intervention, and at 3- and 6-month follow-ups.",[139,140,141,142],"Self Efficacy","Occupational Stress","Well-Being, Psychological","Work Related Stress",[144,145,146,147,148,149],"meta self-efficacy","self-efficacy","job affective well-being","sustainable employability","work stress","work self-efficacy","2025-04-17",{"date":152,"type":38},"2025-04-25",{"date":154,"type":21},"2026-03-01",{"date":156,"type":21},"2027-12-01",{"name":44,"class":45},""]