[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of South Carolina\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":719},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,35,0,25,[9,48,72,100,126,163,185,212,236,267,287,317,342,376,407,433,457,488,509,540,567,599,625,661,688],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":16,"eligibilityCriteria":17,"healthyVolunteers":12,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":28,"conditions":29,"keywords":32,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":36,"lastUpdatePostDateStruct":37,"startDateStruct":40,"completionDateStruct":42,"leadSponsor":44,"locationsCount":47},"100053932","phase-2-superiority-trial-of-aphasia-focused-rehabilitation-with-tdcs-stimulation-100053932",false,"NCT07688551","Superiority Trial of Aphasia-focused Rehabilitation With tDCS Stimulation","Transcranial Direct Current Stimulation to Treat Aphasia: A Superiority Study","STARS","Inclusion Criteria:\n\n* Be willing and able to give informed consent.\n* Be willing and able to comply with study requirements.\n* Be between 25 and 80 years of age.\n* Have used English as the primary language for \\> 15 years.\n* Have the diagnosis of aphasia due to a left hemisphere stroke, confirmed by study physician based on past clinical MRI scan or research scan.\n* Be greater than 6 months post-stroke.\n* Have Broca's aphasia diagnosed by the WAB-R (fluency score ≤ 5, auditory verbal comprehension score 4-10, repetition score 0-7.9, naming and word finding score \\\u003C 9).\n* Correctly name 140 or fewer items on the PNT.\n\nExclusion Criteria:\n\n* History of brain surgery except for during the treatment of the acute stroke.\n* Seizures during the previous 12-months.\n* Compromised skin at or near electrode sites (e.g., rash, eczema, wounds, infection).\n* Correctly name more than 140 out of 175 items during the pre-treatment picture naming test (Philadelphia Naming Test).\n* Western Aphasia Battery-Revised Aphasia Quotient (WAB-R AQ) score of 25 or below.\n* Participants with open skull defects (e.g., greater than 1 cm) in the area underneath the anode electrode positioning or participants with metal implants or electrical stimulators.\n* Participants with continuous oxygen therapy which cannot be discontinued for more than 1 hour.\n* Any condition or situation that the PI determines would significantly interfere with the participant's ability to complete the study.","ALL","25 Years","80 Years",{"count":22,"type":23},130,"ESTIMATED","INTERVENTIONAL",[26,27],"PHASE2","PHASE3","The purpose of this study is to help us understand if adding transcranial Direct Current Stimulation (tDCS), a non-invasive brain stimulation technique, to Speech Therapy improves language recovery in people with Broca's aphasia and is more effective than Speech Therapy alone.",[30,31],"Aphasia","Broca's Aphasia",[33,16,30,34],"tDCS","Stroke","RECRUITING","2026-07-10",{"date":38,"type":39},"2026-07-13","ACTUAL",{"date":41,"type":23},"2026-07-31",{"date":43,"type":23},"2030-06",{"name":45,"class":46},"University of South Carolina","OTHER",3,{"id":49,"slug":50,"hasResults":12,"nctId":51,"briefTitle":52,"officialTitle":53,"acronym":4,"eligibilityCriteria":54,"healthyVolunteers":55,"sex":18,"minAge":56,"maxAge":4,"enrollmentInfo":57,"targetDuration":4,"studyType":24,"phases":59,"briefSummary":60,"conditions":61,"keywords":4,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":63,"lastUpdatePostDateStruct":64,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":71},"100641688","phase-2-mindful-walking-neural-correlates-of-executive-function-in-sc-older-adults-at-risk-of-dementias-100641688","NCT07638046","Mindful Walking Neural Correlates of Executive Function in SC Older Adults at Risk of Dementias","The Impact of Mindful Walking on Neural Correlates of Executive Function in SC Older Adults at Risk of Alzheimer's and Dementias","Inclusion Criteria:\n\n1. Age 60 or older\n2. Sedentary (sit ≥9hrs per day) and not meeting the US physical activity guidelines\n3. Have at least one of the following ADRD risk factors:\n\n   i. family history of ADRD (\\>= first-degree relative) ii. subjective experience of cognitive complaints iii. currently overweight or obese (BMI≥25)\n4. Adequate hearing, visual and cognitive ability to complete study tasks and assessments\n5. Able to walk without others' assistance\n6. Medically stable with or without medication (do not expect to have major health status changes or a surgery in the next 4 months)\n\nExclusion Criteria:\n\n1. Diagnosis of ADRD or other brain abnormalities (i.e., strokes, epilepsy, Parkinson's disease)\n2. Diagnosis of mental disorders (i.e., depression)\n3. Inability to complete surveys on mobile device or wear the activity monitor (i.e., due to arthritis, physical limitations, or other reasons)\n4. Plan to move or have surgery in next 4 months\n5. Currently participate in other study involving physical activity or cognitive training that may interfere with the study outcomes\n6. Unable to provide consent due to disabilities",true,"60 Years",{"count":58,"type":23},54,[26],"Mindful walking is a promising and practical strategy because it combines two activities known to support healthy aging: walking and mindfulness. Unlike many structured exercise programs, mindful walking is low intensity, accessible, and easier to sustain in daily life. It may be especially useful for older adults at elevated risk for ADRD. However, most existing mindful walking studies have focused on mental health outcomes, such as stress reduction, rather than cognitive health. Little is known about whether mindful walking can support cognition or how it may influence brain function. To address this gap and strengthen a future R01 resubmission, the investigators propose a two-arm randomized controlled pilot trial using functional near-infrared spectroscopy (fNIRS), a safe, non-invasive brain imaging method. fNIRS measures brain activity through sensors placed on the scalp and is well-suited for repeated assessments in older adults because it is quiet, portable, painless, and cost-effective. The investigators will recruit racially and ethnically diverse middle-aged and older adults from the Midlands of South Carolina who are at elevated risk for ADRD. Participants will be randomly assigned to one of two groups: mindful walking or walking-only control. Both groups will complete 8 staff-supervised individual sessions over 4 weeks. The mindful walking group will learn and practice simple mindfulness skills while walking in multiple settings, including lab-based, indoor, and outdoor environments, to support real-world use. Findings from this pilot study will provide important evidence on whether mindful walking can support brain and cognitive health in adults at elevated risk for ADRD. The results will also help establish a practical, scalable, and sustainable prevention strategy for underserved aging populations in South Carolina.",[62],"Older Adults With Elevated Dementia Risk","2026-06-12",{"date":65,"type":39},"2026-06-16",{"date":67,"type":23},"2026-06-18",{"date":69,"type":23},"2027-11-17",{"name":45,"class":46},1,{"id":73,"slug":74,"hasResults":12,"nctId":75,"briefTitle":76,"officialTitle":76,"acronym":4,"eligibilityCriteria":77,"healthyVolunteers":55,"sex":18,"minAge":78,"maxAge":79,"enrollmentInfo":80,"targetDuration":4,"studyType":24,"phases":82,"briefSummary":84,"conditions":85,"keywords":87,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":92,"lastUpdatePostDateStruct":93,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":71},"100643607","efficacy-of-center-based-childcare-to-mitigate-unhealthy-weight-gain-in-preschoolers-from-low-income-households-during-the-summer-100643607","NCT07583459","Efficacy of Center-based Childcare to Mitigate Unhealthy Weight Gain in Preschoolers From Low-income Households During the Summer","Inclusion Criteria:\n\n* Children will need to be enrolled in a needs-based pre-K program in our partner organizations to be eligible to participate. No other exclusion criteria will be applied\n\nExclusion Criteria:\n\n\\-","3 Years","5 Years",{"count":81,"type":23},300,[83],"NA","Studies show that preschool-age children are especially vulnerable to accelerated weight gain during the summer, with those from low-income households (≤185% poverty level or Medicaid eligible - the target population for this study) exhibiting the greatest risk of unhealthy weight gain. Despite numerous interventions designed to prevent OWOB, none target preschoolers during summer. For families from low-income households, attending center-based childcare is associated with a lower risk of developing OWOB by 1st grade compared to attending home-based care. Center-based childcare lowers the risk of OWOB through daily rules\u002Froutines that promote healthy behaviors. For families from low-income households, publicly funded center-based childcares (e.g., needs-based pre-K, Head Start) typically operate on an academic\u002Fschool 9-month calendar (Aug-May). During summer, fewer than 30% of preschoolers attend center-based childcare. For many preschoolers from lower-income households, summer may serve as an extended period away from formal center-based childcare, because the out-of-pocket expense may prohibit attendance. This may promote unhealthy behaviors and excessive weight gain. In the majority of US states, publicly funded center-based childcare during the academic\u002Fschool year for families from underserved populations is free; however, center-based childcare during the summer is an out-of-pocket expense for many of these families. Despite parents' desire for childcare during the summer, a major reason children from low-income households do not attend center-based care during summer is cost. This creates unequal access to resources and likely exacerbates health disparities for families from low-income households. Using a structural intervention approach, this study will test the impact of providing free center-based childcare in the summer. This R01 will rigorously test the impact of providing free center-based childcare during the summer on weight status of preschoolers from low-income households (≤185% of poverty level or Medicaid eligible).",[86],"Obesity & Overweight",[88,89,90,91],"Obesity","Preschool","Community","Intervention","2026-06-10",{"date":94,"type":39},"2026-06-11",{"date":96,"type":39},"2026-05-01",{"date":98,"type":23},"2030-06-30",{"name":45,"class":46},{"id":101,"slug":102,"hasResults":12,"nctId":103,"briefTitle":104,"officialTitle":104,"acronym":105,"eligibilityCriteria":106,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":24,"phases":111,"briefSummary":112,"conditions":113,"keywords":115,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":119,"lastUpdatePostDateStruct":120,"startDateStruct":121,"completionDateStruct":123,"leadSponsor":125,"locationsCount":71},"100632801","dietary-insights-and-nutritional-education-in-adults-on-glp-1-therapy-100632801","NCT07518407","Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy","DINE-GLP1","Inclusion Criteria:\n\n* • Age between 18 and 65 years.\n\n  * BMI between 30 - 49.9 kg\u002Fm2 and\u002For diagnosed with type 2 diabetes.\n  * Currently prescribed and using GLP-1 receptor therapy for at least 4 weeks.\n  * Own a smartphone (Android or iOS) with an active data plan to support app-based intervention delivery.\n  * Residing anywhere in the United States.\n  * Must be willing and able to reduce caloric intake.\n  * Be free of major health or psychiatric diseases, drug, or alcohol dependency.\n  * Willing to sign informed consent.\n\nExclusion Criteria:\n\n* • Presence of type 1 diabetes mellitus\n\n  * Severe complications, including but not limited to proliferative retinopathy, severe peripheral neuropathy, nephropathy requiring dialysis, active foot ulcers, or recent hospitalization for diabetic ketoacidosis or hyperosmolar hyperglycemic state within the past 6 months.\n  * Current or recent (within 6 months) participation in another structured weight loss program or clinical trial that may interfere with study outcomes.\n  * Pregnancy, breastfeeding, or plans to become pregnant during the study period.\n  * Current use of another investigational weight loss device or medication.\n  * Diagnosed eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge eating disorder) or other psychiatric conditions that may affect adherence to behavioral interventions, as determined by study staff.\n  * Severe cardiovascular, hepatic, renal, or pulmonary disease that would limit participation in moderate physical activity or dietary modification.\n  * Active cancer treatment (chemotherapy, radiation, or surgery) within the past 12 months.\n  * Substance use disorder or alcohol dependency within the past 12 months.\n  * Cognitive impairment or any medical or mental condition that would interfere with the ability to understand or comply with study procedures.\n  * Lack of reliable internet or smartphone access, or unwillingness to use a mobile app for tracking and communication.","18 Years","65 Years",{"count":110,"type":23},50,[83],"This pilot study will evaluate the feasibility, acceptability, and perceived usefulness of the SWITCH mobile nutrition behavioral intervention among adults receiving GLP-1 receptor agonist therapy for obesity and\u002For type 2 diabetes. Participants will complete baseline assessments, receive a 6-week app-based nutrition intervention consisting of daily dietary self-monitoring and weekly learning modules, and complete follow-up assessments and a structured interview.",[114,88],"Obesity Type 2 Diabetes Mellitus",[116,117,118],"GLP-1 Therapy","Nutritional support","Weight loss therapy","2026-06-09",{"date":63,"type":39},{"date":122,"type":39},"2026-04-06",{"date":124,"type":23},"2027-04-01",{"name":45,"class":46},{"id":127,"slug":128,"hasResults":12,"nctId":129,"briefTitle":130,"officialTitle":131,"acronym":4,"eligibilityCriteria":132,"healthyVolunteers":12,"sex":18,"minAge":133,"maxAge":19,"enrollmentInfo":134,"targetDuration":4,"studyType":24,"phases":136,"briefSummary":137,"conditions":138,"keywords":145,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":155,"lastUpdatePostDateStruct":156,"startDateStruct":158,"completionDateStruct":160,"leadSponsor":162,"locationsCount":71},"100637254","improving-the-hiv-care-continuum-with-mhealth-technology-100637254","NCT07631104","Improving the HIV Care Continuum With mHealth Technology","Improving the HIV Care Continuum for Youth in the Deep South Through Mobile Health Technology","Inclusion Criteria:\n\n* Between the ages of 16 and 25 years\n* Diagnosed with HIV\n* Resident of South Carolina\n* Proficient in English\n\nExclusion Criteria:\n\n* Under 16 years of age or over 25 years of age\n* Is not a person living with HIV\n* Is not a resident of South Carolina\n* Is not proficient in English","16 Years",{"count":135,"type":23},40,[83],"Youth living with HIV (YLHIV) face barriers to engagement and retention in HIV care, show poor medication adherence, and often fail to achieve and maintain viral suppression. YLHIV in the southern United States have particularly poor care engagement outcomes. South Carolina is one of nine states identified as \"key drivers\" of the US HIV epidemic, and HIV rates for youth in South Carolina have risen in recent years. Tailored interventions are urgently needed to improve outcomes for this population. One promising approach is to reach YLHIV via mobile Health (mHealth) technology, yet few efforts have sought to tailor mHealth interventions to the needs of YLHIV in the southern US. Thus, the scientific objective of this study is to pilot test a new mHealth intervention, called MindBodyU, designed to increase engagement\u002Fretention in care and ART adherence among YLHIV in South Carolina. In this study, investigators will evaluate the feasibility, acceptability, and initial efficacy of the mHealth intervention with a six-month pilot trial with 40 YLHIV in South Carolina.",[139,140,141,142,143,144],"HIV - Human Immunodeficiency Virus","HIV Antiretroviral Therapy (ART) Adherence","mHealth Application","mHealth Intervention","Continuum of Care","Youth With HIV",[146,147,148,149,150,151,152,153],"Youth living with HIV (YLHIV)","immunology","HIV","adolescents","emerging\u002Fyoung adults","eHealth\u002FmHealth\u002Fdigital health","adherence\u002Fself-management","psychosocial intervention","NOT_YET_RECRUITING","2026-06-02",{"date":157,"type":39},"2026-06-05",{"date":159,"type":23},"2026-06-01",{"date":161,"type":23},"2028-06-01",{"name":45,"class":46},{"id":164,"slug":165,"hasResults":12,"nctId":166,"briefTitle":167,"officialTitle":167,"acronym":4,"eligibilityCriteria":168,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":169,"targetDuration":4,"studyType":24,"phases":170,"briefSummary":171,"conditions":172,"keywords":174,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":177,"lastUpdatePostDateStruct":178,"startDateStruct":179,"completionDateStruct":181,"leadSponsor":183,"locationsCount":184},"100577525","train-your-brain-fitness-sc-an-exercise-intervention-for-people-with-cognitive-impairments-100577525","NCT06799429","Train Your Brain Fitness SC: An Exercise Intervention for People With Cognitive Impairments","Inclusion criteria:\n\n* adult (age \\>18)\n* medical diagnosis of mild-moderate cognitive impairment\n* medical clearance by referring provider for exercise\n* able to follow 2-step commands\n\nExclusion criteria:\n\n* significant pain with movement (\\>5\u002F10)\n* severe balance impairments or lack of independence on and off exercise equipment (by physical therapist judgment at Intake)",{"count":110,"type":23},[83],"The goal of this clinical trial is to test a twice a week, moderate intensity exercise and coaching program (an in-person group and a distance group) for adults with mild-moderate cognitive impairments living in South Carolina. The main questions it aims to answer are:\n\n1. Is the program practical to conduct, and it is acceptable and enjoyable? The hypothesis is that it will be possible to recruit participants, obtain the desired dosage of moderate intensity fitness and strength training twice a week for both groups.\n2. Are their changes at 3, 6, 9 and 12 months in endurance, mobility, cognitive function and perception of cognitive function? The hypotheses are that endurance, strength and mobility will improve and cognitive measures will not decline (remain the same or improve) for both groups.",[173],"Mild-moderate Cognitive Impairment",[175,176],"cognitive impairment","exercise","2026-05-27",{"date":159,"type":39},{"date":180,"type":39},"2026-03-13",{"date":182,"type":23},"2026-11-17",{"name":45,"class":46},2,{"id":186,"slug":187,"hasResults":12,"nctId":188,"briefTitle":189,"officialTitle":190,"acronym":191,"eligibilityCriteria":192,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":193,"targetDuration":4,"studyType":24,"phases":195,"briefSummary":196,"conditions":197,"keywords":198,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":204,"lastUpdatePostDateStruct":205,"startDateStruct":207,"completionDateStruct":209,"leadSponsor":211,"locationsCount":71},"100640815","recovery-from-post-stroke-aphasia-with-rtms-targeting-left-or-right-anterior-temporal-lobe-100640815","NCT07608588","Recovery From Post-Stroke Aphasia With rTMS Targeting Left or Right Anterior Temporal Lobe","Recovery From Post-Stroke Aphasia With rTMS Targeting the Anterior Temporal Lobe: Interhemispheric Activation Changes and Lesion-Connectome-Based Predictive Outcomes","ATLAS","Inclusion Criteria:\n\n* Right-handedness (assesed using the Edinburgh Handedness Inventory)\n* Native English speakers\n* Single left hemispheric stroke\n* Diagnosis of aphasia and lexicosemantic impairments (e.g., anomia, semantic errors in picture naming or spontaneous speech) confirmed by a Speech and Language Pathologist or Physician\n\nExclusion Criteria:\n\n* Severely impaired auditory comprehension (WAB Comprehension score of 0 or 1)\n* Major phonological impairments (defined as \\> 2 errors in non-word repetition of one- and two-syllable items on the PALPA, 2)\n* Contraindications to rTMS (e.g., uncontrolled epilepsy, history of seizures, intracranial ferromagnetic body, cochlear implant, or factors that lower seizure threshold (see Rossi et al., 2021)\n* Contraindication to MRI\n* Stroke involving the left ATL\n* Severe depression or psychiatric history\n* Illiteracy\n* Known neurodegenerative disorders\n* Severe uncorrected visual or hearing impairments",{"count":194,"type":23},45,[83],"This project aims to tailor repetitive Transcranial Magnetic Stimulation (rTMS) target to the clinical profile of post-stroke aphasia, specifically focusing on lexicosemantic impairments, to enhance recovery. Functional Magnetic Resonance Imaging (fMRI) will provide critical insights into the effects of facilitatory versus inhibitory stimulation on interhemispheric balance. Additionally, this study will generate new data on how lesion localization and brain connectivity influence individual responses to rTMS, explaining variability in treatment efficacy.",[34,30],[199,200,201,202,203],"aphasia","stroke","rTMS","brain stimulation","speech and language therapy","2026-05-26",{"date":206,"type":39},"2026-05-29",{"date":208,"type":39},"2026-05-15",{"date":210,"type":23},"2027-07-30",{"name":45,"class":46},{"id":213,"slug":214,"hasResults":12,"nctId":215,"briefTitle":216,"officialTitle":216,"acronym":217,"eligibilityCriteria":218,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":219,"targetDuration":4,"studyType":24,"phases":221,"briefSummary":222,"conditions":223,"keywords":225,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":228,"lastUpdatePostDateStruct":229,"startDateStruct":231,"completionDateStruct":233,"leadSponsor":235,"locationsCount":71},"100575167","optimizing-a-remote-based-physical-activity-intervention-for-adults-with-total-knee-replacement-100575167","NCT06768762","Optimizing a Remote-based Physical Activity Intervention for Adults With Total Knee Replacement","MOST Energized","Inclusion Criteria:\n\n* had a knee replacement (including primary, staged or independent bilateral, or revision) at least 12 months ago\n* have a computer, tablet, or smartphone with active internet access\n* self-report engaging in less than 60 minutes\u002Fweek of moderate-intensity physical activity\n* be English-speaking and able to read consent and study materials written in English\n* be willing to complete the 4 remote assessments, including physical activity monitoring\n* be willing to be randomized to receive 0-4 supplemental intervention components.\n\nExclusion Criteria:\n\n* any contraindications to physical activity (e.g., chest pain)\n* have a scheduled surgery within the next 12 months (e.g., hip or knee replacement)\n* have a mobility limiting comorbidity unrelated to knee replacement\n* live outside of the continental U.S\n* do not currently have a physician or orthopedic surgeon whom they see regularly\n* are currently participating in physical therapy (for knee)\n* are participating in a structured weight loss or physical activity program\n* unable to provide proof of knee replacement surgery\n* have a BMI \\>40kg\u002Fm2\n* score \\>30 on PROMIS cognitive function",{"count":220,"type":23},336,[83],"The purpose of this study is to identify which supplemental intervention components added to an online exercise program contribute to the greatest increases in physical activity (total MVPA and percent meeting guidelines \\[≥150 min\u002Fweek of MVPA\\]) in adults with knee replacement at 6 and 12 months. Secondary outcomes will examine changes in pain and physical function.",[224],"Knee Replacement",[226,176,227],"knee replacement","online","2026-04-28",{"date":230,"type":39},"2026-05-05",{"date":232,"type":39},"2025-01-21",{"date":234,"type":23},"2029-07-31",{"name":45,"class":46},{"id":237,"slug":238,"hasResults":12,"nctId":239,"briefTitle":240,"officialTitle":241,"acronym":242,"eligibilityCriteria":243,"healthyVolunteers":12,"sex":244,"minAge":107,"maxAge":4,"enrollmentInfo":245,"targetDuration":4,"studyType":24,"phases":247,"briefSummary":248,"conditions":249,"keywords":253,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":259,"lastUpdatePostDateStruct":260,"startDateStruct":262,"completionDateStruct":264,"leadSponsor":266,"locationsCount":71},"100628156","community-health-worker-coaching-to-reduce-cardiovascular-risk-among-women-after-a-hypertensive-disorder-of-pregnancy-100628156","NCT07457970","Community Health Worker Coaching to Reduce Cardiovascular Risk Among Women After a Hypertensive Disorder of Pregnancy","Community Health Worker Coaching to Reduce CVD Disease Risk Among Women After a Hypertensive Disorder of Pregnancy","HERHEART","Inclusion Criteria:\n\n* 28 weeks gestation\n* A current hypertensive disorders in pregnancy or chronic hypertension\n* Singletons\n* Access to phone\n* Plan to deliver at Prisma Health-Midlands Hospital.\n\nExclusion Criteria:\n\n* Multiples\n* Fetal anomaly\n* Don't speak English\n* Already delivered a baby greater than 14 days ago.","FEMALE",{"count":246,"type":23},240,[83],"The goal of this clinical trial is to find out whether an enhanced program works better than remote blood pressure monitoring (RBPM) alone for women who had high blood pressure during pregnancy. The enhanced program combines RBPM with a lifestyle program led by a community health worker (CHW).\n\nThe study will examine whether the enhanced program helps women better control their blood pressure, lowers their average resting blood pressure, improves heart health risk factors (such as weight, diet, physical activity), supports mental well-being, and reduces emergency department visits and hospital readmissions by 6 months after delivery.",[250,251,252],"Blood Pressure Monitoring","Hypertension (HTN)","Pregnancy",[254,255,256,257,258],"community health worker","lifestyle intervention","Blood pressure monitoring","postpartum","Cardiovascular risk","2026-04-27",{"date":261,"type":39},"2026-05-04",{"date":263,"type":39},"2026-04-24",{"date":265,"type":23},"2029-07-15",{"name":45,"class":46},{"id":268,"slug":269,"hasResults":12,"nctId":270,"briefTitle":271,"officialTitle":272,"acronym":273,"eligibilityCriteria":274,"healthyVolunteers":55,"sex":18,"minAge":107,"maxAge":108,"enrollmentInfo":275,"targetDuration":4,"studyType":24,"phases":276,"briefSummary":277,"conditions":278,"keywords":4,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":122,"lastUpdatePostDateStruct":280,"startDateStruct":282,"completionDateStruct":284,"leadSponsor":286,"locationsCount":4},"100632116","optimizing-lifestyles-through-increased-vegetable-rich-eating-pilot-study-100632116","NCT07509502","Optimizing Lifestyles Through Increased Vegetable-rich Eating Pilot Study","Building on the Dietary Guidelines: 3 Dietary Pattern (DG3D) Study - Testing a Teaching Kitchens and Food is Medicine Approach for Type 2 Diabetes Prevention","OLIVE Pilot","Inclusion Criteria:\n\n* 18-65 years of age\n* BMI between 25- 49.9 kg\u002Fm2\n* Live in a southern state (as classified by the US Census)\n* Be able to complete all survey assessments via computer or phone\n* Have a wi-fi connection at home or other site to access Zoom-delivered interventions\n* Have three or more type 2 diabetes risk factors (NIDDK Risk factors for T2DM)\n* Own a digital body weight scale, have regular access, or be willing to purchase one\n\nExclusion Criteria:\n\n* Currently participating in a weight loss program or taking weight loss medications\n* Has lost more than 10 pounds in the past 6 months\n* Diagnosed with major health or psychiatric diseases, drug or alcohol dependency, thyroid conditions, diabetes, or pregnancy\n* Pregnant (or have been pregnant in the last 6 months), anticipating on becoming pregnant in the next 3 months, or currently breastfeeding\n* Diagnosed with an eating disorder as screened by the Eating disorder Screen for Primary care \\[ESP\\].",{"count":135,"type":23},[83],"The goal of this pilot clinical trial is to examine how receipt of ingredients for a Mediterranean diet (with or without nutrition classes) impacts Type 2 Diabetes Mellitus risk factors among adults in the US South. The main question it aims to answer is:\n\n\\- Will greater improvements in diet quality (HEI Score) and body weight be seen in the group that receives grocery delivery and nutrition classes (TK+FiM) compared to the group receiving grocery delivery only (FiM only)?\n\nResearchers will evaluate the changes in diet quality and body weight among participants in each group to see which group experiences greater improvements.\n\nParticipants will:\n\n* be randomly assigned to either receive weekly grocery deliveries and attend weekly virtual nutrition classes for 4 weeks or receive weekly grocery deliveries only.\n* be asked to complete surveys\u002Fquestionnaires at the baseline and 4-week timepoints in the study.\n* be asked to participate in a post-study focus group to talk about their experiences during the intervention.",[279,86],"Type 2 Diabetes (T2DM)",{"date":281,"type":39},"2026-04-13",{"date":283,"type":23},"2026-06",{"date":285,"type":23},"2027-07",{"name":45,"class":46},{"id":288,"slug":289,"hasResults":12,"nctId":290,"briefTitle":291,"officialTitle":292,"acronym":293,"eligibilityCriteria":294,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":295,"targetDuration":4,"studyType":24,"phases":297,"briefSummary":298,"conditions":299,"keywords":306,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":309,"lastUpdatePostDateStruct":310,"startDateStruct":312,"completionDateStruct":314,"leadSponsor":316,"locationsCount":71},"100583770","dose-response-of-exercise-for-arthritis-management-100583770","NCT06880653","Dose Response of Exercise for Arthritis Management","Examination of the Dose Response Relationship Between Physical Activity and Arthritis-Attributable Outcomes","DREAM","Inclusion Criteria:\n\n* 18 years or older\n* Have a doctor diagnosed form of arthritis, rheumatoid arthritis, gout, lupus, or fibromyalgia\n* Ability to read and write in English\n\nExclusion Criteria:\n\n* Have any contraindications to exercise (besides arthritis)\n* Engage in \\>45 min\u002Fweek of Actigraph assessed moderate to vigorous intensity activity\n* Are pregnant, breastfeeding, or planning to become pregnant in the next year\n* Are planning to relocate out of the Columbia, SC area in the next 12 months,\n* Do not have a device compatible with Fitbit\n* Have uncontrolled hypertension (e.g., systolic blood pressure \\> 160 mmHg or diastolic blood pressure \\> 100 mmHg)\n* Plan to have a surgery that affects mobility in the next 12 months\n* Have a serious cognitive impairment.\n* Not willing to be randomized to any of the 3 conditions, do not believe they could adhere to the goals, or do not believe they could achieve the highest dose of activity (150 minutes\u002Fweek).",{"count":296,"type":23},285,[83],"The purpose of the study is to see examine the effects of 3 different levels of physical activity (45 minutes\u002Fweek, 90 minutes\u002Fweek, or 150 minutes\u002Fweek) on arthritis symptoms.",[300,301,302,303,304,305],"Arthritis","Rheumatoid Arthritis (RA)","Gout","Fibromyalgia (FM)","Osteoarthritis","Lupus Erythematosus, Systemic",[307,176,308],"arthritis","physical activity","2026-04-02",{"date":311,"type":39},"2026-04-03",{"date":313,"type":39},"2025-03-28",{"date":315,"type":23},"2029-04-30",{"name":45,"class":46},{"id":318,"slug":319,"hasResults":12,"nctId":320,"briefTitle":321,"officialTitle":322,"acronym":323,"eligibilityCriteria":324,"healthyVolunteers":12,"sex":18,"minAge":325,"maxAge":20,"enrollmentInfo":326,"targetDuration":4,"studyType":24,"phases":328,"briefSummary":329,"conditions":330,"keywords":332,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":335,"lastUpdatePostDateStruct":336,"startDateStruct":337,"completionDateStruct":339,"leadSponsor":341,"locationsCount":71},"100414869","telerehabilitation-for-aphasia-terra-100414869","NCT04682223","Telerehabilitation for Aphasia (TERRA)","Center for the Study of Aphasia Recovery (C-STAR): Telerehabilitation for Aphasia (TERRA)","TERRA","Inclusion Criteria:\n\n1. Participants must have sustained a left hemisphere ischemic or hemorrhagic stroke at least 12 months prior to enrollment.\n2. Participants must primarily speak English for at least the past 20 years.\n3. Participants must be capable of giving informed consent or indicating another to provide informed consent.\n4. Participants must be between 21-80 years of age.\n5. Participants must be magnetic resonance imaging (MRI) compatible (e.g., no metal implants, not claustrophobic) on a 3-Tesla (3T) scanner.\n\nExclusion Criteria:\n\n1. Participants must not have previous neurological disease affecting the brain (e.g. history of traumatic brain injury).\n2. Participants must not have severely limited speech production (severe unintelligibility) and\u002For auditory comprehension that interferes with adequate participation in the therapy provided (i.e., WAB-R Spontaneous Speech rating scale score of 0-1 or WAB-R Comprehension score of 0-1).\n3. Participants must not have a history of stroke to the right hemisphere of the brain.\n4. Participants must not have a bilateral, cerebellar or brainstem stroke.\n5. Participants must not have anything that makes them be 3T MRI incompatible\n6. Insufficient intelligible speech to provide accurate responses with discourse\u002Fnaming.","21 Years",{"count":327,"type":23},100,[83],"Speech-language therapy is generally found to be helpful in the rehabilitation of aphasia. However, not all patients with aphasia have access to adequate treatment to maximize their recovery. The goal of this project is to compare the efficacy of telerehabilitation or Aphasia Remote Therapy (ART) to the more traditional In-Clinic Therapy (I-CT).",[30,34,331],"Stroke Rehabilitation",[199,200,333,334],"telerehabilitation","speech-language therapy","2026-04-01",{"date":309,"type":39},{"date":338,"type":39},"2021-05-05",{"date":340,"type":23},"2027-03",{"name":45,"class":46},{"id":343,"slug":344,"hasResults":12,"nctId":345,"briefTitle":346,"officialTitle":347,"acronym":4,"eligibilityCriteria":348,"healthyVolunteers":55,"sex":18,"minAge":4,"maxAge":4,"enrollmentInfo":349,"targetDuration":4,"studyType":24,"phases":350,"briefSummary":351,"conditions":352,"keywords":364,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":370,"lastUpdatePostDateStruct":371,"startDateStruct":372,"completionDateStruct":373,"leadSponsor":375,"locationsCount":71},"100619127","implementation-facilitation-of-exercise-is-medicine-greenville-100619127","NCT07340580","Implementation Facilitation of Exercise is Medicine Greenville","Facilitating Health System Implementation of Physical Activity Screening and Referral to Community-Based Programs: Exercise is Medicine Greenville","The primary aim of this study is implementation facilitation at the clinic level. The secondary aim of this study is at the patient level. Therefore we have divided our inclusion\u002Fexclusion eligibility criteria by primary and secondary aim.\n\n1\\. Clinic (primary aim) Inclusion criteria\n\n* Currently EIMG-activated Prisma Health-Upstate Primary Care clinic (family or internal medicine)\n* Adopted EIMG \\>= 6 months prior to the beginning of this study\n\nExclusion criteria\n\n* Not EIMG-activated\n* Adopted EIMG \\\u003C 6 months prior to the beginning of this study\n* Greater than 15 miles from the nearest YMCA\n\n  1\\. Primary care clinic staff (primary aim) Inclusion criteria\n* At least 18 years of age\n* Has worked at the Prisma Health-Upstate clinic since the start date of the intervention in the respective wave, i.e., Pre-IF start date for each wave\n* Has clinical encounters with a minimum of 25 patients per month\n* Study clinic is their primary clinic (\\>50% of their working time)\n* Able to understand and communicate in English\n\nExclusion criteria\n\n* Less than 18 years of age\n* Work at the Prisma Health-Upstate clinic started after the Pre-IF phase began\n* Has clinical encounters with \\\u003C25 patients per month\n* Unable to speak or understand English\n* Adults unable to provide consent\n\n  2\\. Patient (secondary aim) Inclusion criteria (must meet all of below)\n* Age \\>= 18 and \\\u003C= 80 years\n* Clinically eligible (diagnosis of hypertension, dyslipidemia, obesity, diabetes, or physical inactivity) to receive an EIMG referral\n* A healthcare visit with an eligible encounter type (evaluation, telemedicine, consult, office visit, e-visit, follow-up, appointment, education, multidisciplinary visit, nutrition, occupational medicine-office visit)\n* A healthcare visit at a participating clinic\n\nExclusion criteria\n\n* Age \\\u003C 18 or \\> 80 years\n* Current referral to Physical therapy or occupational therapy\n* Current referral to cardiac, pulmonary, or oncology rehab\n* One of the following visit diagnoses listed below:\n\n  * Alzheimer's disease\n  * Amyotrophic lateral sclerosis\n  * angina or chest pain\n  * congenital stenosis of aortic valve\n  * congenital insufficiency of aortic valve\n  * moderate or severe persistent asthma\n  * typical or atypical atrial flutter\n  * autonomic dysreflexia\n  * acute bronchitis\n  * cerebral infarction\n  * encounter for chemotherapy\n  * chronic kidney disease (stage 3-5)\n  * end stage renal disease\n  * coma\n  * acute chronic obstructive pulmonary disease\n  * unspecified dementia\n  * dependence on renal dialysis\n  * trisomy 21\n  * pulmonary embolism\n  * venous embolism and thrombosis\n  * history of falling\n  * acute fracture\n  * left ventricular failure\n  * congestive heart failure\n  * hypertensive urgency, emergency or crisis\n  * diabetes with ketoacidosis\n  * chronic respiratory failure\n  * dependence on supplemental oxygen\n  * myocardial infarction\n  * osteoporosis with current fracture\n  * encounter for palliative care\n  * paraplegia or quadriplegia\n  * Parkinson disease\n  * pneumonia\n  * encounter for supervision of pregnancy\n  * encounter for radiation therapy\n  * serious mental illness (schizophrenia, psychotic disorder)\n  * homicidal or suicidal ideations\n  * sepsis\n  * injury of spinal cord\n  * presence of coronary stent\n  * dependence on wheelchair or ambulatory aid\n\nFor patients completing accelerometry data collection, the additional inclusion\u002Fexclusion criteria apply:\n\nInclusion criteria:\n\n* Received an EIMG referral and scheduled for orientation\n* Attending orientation at two pre-determined community PA facilities (these sites were selected due to each being the largest urban and rural YMCA referral sites in the study)\n\nExclusion criteria:\n\n* Unable to provide verbal informed consent\n* Planning on travel or vacation during data collection, as patient PA behavior is anticipated to differ from 'everyday' PA behavior at home\n* Unable to wear a watch during work hours due to employment restrictions e.g., food service, healthcare, operating heavy machinery\u002Fconstruction, laboratory-based work etc.\n\nIn addition, for patients completing interviews, the additional inclusion\u002Fexclusion criteria apply:\n\nInclusion criteria:\n\n\\- Received an EIMG referral\n\nExclusion criteria:\n\n* Unable to provide verbal informed consent\n* Unable to speak or understand English\n* \\\u003C18 years of age",{"count":5,"type":23},[83],"A public health priority exists for the U.S. healthcare sector to integrate physical activity (PA) as a part of the patient care model. This research will provide valuable information on facilitating optimal implementation of a clinic-to-community model that identifies, refers, and enrolls physically inactive patients to community-based PA programs for the prevention and treatment of chronic diseases. Further, this work will provide evidence on the cost-effectiveness of integrating PA in healthcare systems as a population health management strategy.",[353,354,355,356,357,358,359,360,361,362,363],"Physical Inactivity","Dyslipidemia","Obesity and Overweight","Hypertension","Diabetes","Health Care Delivery","Patients","Chronic Disease","Exercise","Physical Activity","Implementation Science",[365,366,367,368,369],"Implementation Facilitation","Physical activity referral scheme","Effectiveness-implementation hybrid type 3","Pragmatic design","Stepped wedge","2026-03-27",{"date":309,"type":39},{"date":96,"type":23},{"date":374,"type":23},"2030-07-31",{"name":45,"class":46},{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":382,"eligibilityCriteria":383,"healthyVolunteers":55,"sex":18,"minAge":384,"maxAge":385,"enrollmentInfo":386,"targetDuration":4,"studyType":24,"phases":388,"briefSummary":389,"conditions":390,"keywords":392,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":398,"lastUpdatePostDateStruct":399,"startDateStruct":401,"completionDateStruct":403,"leadSponsor":405,"locationsCount":406},"100630686","phase-3-combined-nutrition-and-parenting-study-100630686","NCT07490899","Combined Nutrition and Parenting Study","Impact of Combined Nutrition, Responsive Parenting, and Health Intervention on Childhood Development Study","BUNDLE","Inclusion Criteria:\n\n* Resides in selected community in Liberia\n* Household has a child aged 6-30 months at study enrollment\n* Child has a primary female caregiver and second (male or female) caregiver ≥ 18 years of age\n* Caregivers and child intend to continue residing in the study area for the follow-up duration\n* Both primary and second caregiver provide informed consent\n\nExclusion Criteria:\n\n* Children with known allergies to eggs or fish\n* Caregivers with cognitive and severe physical disabilities who are unable to implement intervention activities\n* Children with developmental disabilities","6 Months","30 Months",{"count":387,"type":23},2240,[27],"This study aims to evaluate whether early childhood development is improved by a bundled set of interventions that promote responsive stimulation and improved nutrition by the provision of eggs and dried fish (nutrient-dense animal source foods), and whether, in combination, these stimulation and nutrition interventions are more effective than responsive stimulation or food provision alone.",[391],"Early Childhood Development (ECD)",[393,394,395,396,397],"cluster randomized trial","responsive caregiving","nutrition","early childhood development","animal source food","2026-03-18",{"date":400,"type":39},"2026-03-24",{"date":402,"type":23},"2027-02",{"date":404,"type":23},"2028-06",{"name":45,"class":46},4,{"id":408,"slug":409,"hasResults":12,"nctId":410,"briefTitle":411,"officialTitle":411,"acronym":412,"eligibilityCriteria":413,"healthyVolunteers":12,"sex":244,"minAge":107,"maxAge":414,"enrollmentInfo":415,"targetDuration":4,"studyType":417,"phases":4,"briefSummary":418,"conditions":419,"keywords":421,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":426,"lastUpdatePostDateStruct":427,"startDateStruct":428,"completionDateStruct":430,"leadSponsor":432,"locationsCount":71},"100523516","use-of-a-cloud-connected-remote-blood-pressure-monitoring-program-during-the-postpartum-period-for-hypertensive-women-100523516","NCT06096701","Use of a Cloud-connected Remote Blood Pressure Monitoring Program During the Postpartum Period for Hypertensive Women","BP-ME","Inclusion Criteria:\n\n* Pregnant individuals with hypertensive disorders\n* Speak English\n* At least 18 years old\n* Medicaid coverage\n* Between 20 weeks of pregnancy and 2 weeks postpartum\n* Postpartum admission at Prisma Health Richland with hypertensive disorder within 2 weeks postpartum\n\nExclusion Criteria:\n\n* Not planning to deliver at Prisma Health Richland\n* Less than 20 weeks of pregnancy\n* More than 2 weeks postpartum","54 Years",{"count":416,"type":23},540,"OBSERVATIONAL","Hypertensive disorders (HD), including preeclampsia, gestational hypertension, chronic hypertension, and chronic hypertension with superimposed preeclampsia, affect around 10-20% of pregnant women in the United States and are significantly associated with maternal mortality and morbidity, particularly in the postpartum period. The prevalence of HD is on the rise in the United States and has increased from 13% in 2017 to 16% in 2019 owing to an increase in advanced maternal age, obesity, and diabetes. There are major racial disparities in HD and subsequent maternal mortality and morbidity. HD affect more than 1 in 5 delivery hospitalizations of Black women. Black women with HD are also more likely than white women with HD to have more adverse postpartum blood pressure trajectories which leads to a higher incidence of hypertension related hospital readmissions (readmission for hypertension during the first 6-weeks postpartum: 16.9% among Black women vs. 9.5% among white women, p=0.02) and cardiovascular-related adverse events. However, most of the management recommendations have been centered around blood pressure targets during the antepartum period with significantly less attention paid to the postpartum period despite evidence showing that hypertensive disorders are the most common reason for postpartum readmissions and are associated with increased maternal mortality and morbidity and a significant cost burden.",[420],"Hypertensive Disorder",[422,423,424,425],"Preeclampsia","Gestational hypertension","Eclampsia","Chronic hypertension","2026-03-16",{"date":398,"type":39},{"date":429,"type":39},"2024-02-13",{"date":431,"type":23},"2028-07",{"name":45,"class":46},{"id":434,"slug":435,"hasResults":12,"nctId":436,"briefTitle":437,"officialTitle":438,"acronym":4,"eligibilityCriteria":439,"healthyVolunteers":55,"sex":18,"minAge":440,"maxAge":441,"enrollmentInfo":442,"targetDuration":4,"studyType":24,"phases":443,"briefSummary":444,"conditions":445,"keywords":447,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":450,"lastUpdatePostDateStruct":451,"startDateStruct":452,"completionDateStruct":454,"leadSponsor":456,"locationsCount":4},"100629201","family-centered-implementation-of-parent-training-for-autistic-toddlers-in-early-intervention-100629201","NCT07471594","Family-Centered Implementation of Parent Training for Autistic Toddlers in Early Intervention","Family-Centered Implementation of Parent Training for Emotion Regulation in Autistic Toddlers Within the Part C Early Intervention System","The following is a list of inclusion and exclusion criteria by participant group across all three research aims.\n\nInclusion Criteria for All Participants:\n\n* Able to provide written and informed consent;\n* Both sexes and all racial and ethnic origins;\n* English fluency (necessary for informed consent and measure completion)\n\nInclusion Criteria for Providers:\n\n* Is between 18 and 75 years of age\n* Holds a contract with or formally employed by BabyNet\n* Provides services within BabyNet at least one half-hour per week\n* Provides therapeutic services within BabyNet to at least one child 12-36 months who is 1) at high-likelihood for ASD based on caregiver or provider concern for social communication delays and a positive screen on the POSI, and 2) has elevated emotion dysregulation based on a raw score of at least 15 on the EDI-YC Reactivity Index.\n\nExclusion Criteria for Providers:\n\n* Not contracted or employed by BabyNet\n* Provides services less than one half-hour per week\n* Does not provide services to a child 12-36 months of age at high-likelihood for ASD and with elevated emotion dysregulation (based on the POSI and the EDI-YC)\n\nInclusion Criteria for Caregiver in Caregiver-Child Dyad:\n\n* Is between 18 and 75 years of age\n* Is the legal guardian of the participating child\n* Child is receiving services within BabyNet at least one half-hour per week - Caregiver participates or is present for BabyNet services\n\nExclusion Criteria for Caregiver in Caregiver-Child Dyad:\n\n* Not between 18 and 75 years of age\n* Not the legal guardian of the child\n* Not able to be present for BabyNet services\n\nInclusion Criteria for Children in Caregiver-Child Dyad:\n\n* Is between 12 and 36 months of age\n* Is enrolled in BabyNet services at least one half-hour per week\n* Is considered to be at high-likelihood for ASD based on caregiver or provider concern for social communication delays and a positive screen on the POSI\n* Has elevated emotion dysregulation based on a raw score of at least 15 on the EDI-YC Reactivity Index.\n\nExclusion Criteria for Children in Caregiver-Child Dyad:\n\n* Is not between 12 and 36 months of age\n* Is not receiving services in BabyNet at least one half-hour per week\n* Is not considered to be at high-likelihood for ASD based on caregiver or provider concern for social communication delays and a positive screen on the POSI\n* Does not have elevated emotion dysregulation based on a raw score of at least 15 on the EDI-YC Reactivity Index.","12 Months","36 Months",{"count":135,"type":23},[83],"Early Intervention (EI) systems are ill-equipped to serve the many children 12 to 36 months with early signs or a diagnosis of autism spectrum disorder (ASD). EI funded by Part C of the Individuals with Disabilities Education Act (IDEA) uses home-based service delivery, emphasizes family-centered care, and prioritizes family-defined concerns (i.e., patient-centered outcomes). The Part C system is ideally situated to provide family-based intervention to children aged birth to three. However, Part C EI providers receive little training in ASD or the challenges characterizing ASD in toddlerhood, most notably emotion regulation. This study introduces Parent Training for emotion regulation for autistic toddlers into the Part C EI system, determines its feasibility and preliminary efficacy in this setting, and assesses what family, provider, and system-level factors may facilitate the uptake of parent training in the Part C EI system.",[446],"Autism",[448,449],"emotion regulation","early intervention","2026-03-10",{"date":180,"type":39},{"date":453,"type":23},"2026-04",{"date":455,"type":23},"2027-09",{"name":45,"class":46},{"id":458,"slug":459,"hasResults":12,"nctId":460,"briefTitle":461,"officialTitle":461,"acronym":4,"eligibilityCriteria":462,"healthyVolunteers":55,"sex":18,"minAge":107,"maxAge":19,"enrollmentInfo":463,"targetDuration":4,"studyType":24,"phases":465,"briefSummary":466,"conditions":467,"keywords":472,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":71},"100552181","theory-based-social-media-intervention-for-non-medical-use-of-prescription-opioids-in-young-adults-100552181","NCT06469749","Theory-based Social Media Intervention for Non-medical Use of Prescription Opioids in Young Adults","Inclusion Criteria:\n\n* aged 18-25 years\n* from the U.S.\n* can read and speak English\n* engage in non-medical use of prescription opioids in the past three months: taking prescription opioids without a doctor's prescription\u002Ftaking more doses of prescription opioids than what a prescription allows\u002Fusing prescription opioid for reasons other than a medical purpose\n* use Instagram three times a week or more in the past three months\n\nExclusion Criteria:\n\n* receiving substance use interventions in the past three months\n* are diagnosed with substance use disorders\n* are not proficient in English",{"count":464,"type":23},70,[83],"Brief Summary\n\nThe purposes of this study are to develop and implement a peer-led intervention program on Instagram for promoting prescription opioid use management and fostering psychosocial skills among young adults who engage in non-medical use of prescription opioids in the United State. The specific aims of the study include:\n\n(1) To implement and test the feasibility of the 12-week peer-led intervention modules on Instagram among young adults who are randomly assigned to either receive the intervention (intervention group) or not receive the intervention (control group)\n\nParticipants who are assigned to the intervention group will be paired with a peer leader and attend to peer-guided interactive modules on Instagram over 12 weeks. They will complete an online survey at 1st week and 12th week, as well as brief evening surveys every two days during the intervention. The control group will not take part in intervention activities but will complete an online survey at 1st week and 12th week.",[468,469,470,471],"Young Adults","Past-3-month Non-medical Use of Prescription Opioids","Without Substance Use Disorders","Social Media Users",[473,468,474,475,476,477,478,479],"opioids","Information-Motivation-Behavioral skills Model","Psychosocial factors","social media","Resilience","Mental health","Peer role model","2026-02-20",{"date":482,"type":39},"2026-02-23",{"date":484,"type":23},"2026-11-01",{"date":486,"type":23},"2029-03-31",{"name":45,"class":46},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":492,"acronym":105,"eligibilityCriteria":493,"healthyVolunteers":12,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":494,"targetDuration":495,"studyType":417,"phases":4,"briefSummary":496,"conditions":497,"keywords":499,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":501,"lastUpdatePostDateStruct":502,"startDateStruct":504,"completionDateStruct":506,"leadSponsor":508,"locationsCount":184},"100617035","dietary-insights-and-nutrition-experiences-in-adults-on-glp-1-therapy---a-study-on-diet-quality-changes-in-adults-on-glp-1-therapy-100617035","NCT07313384","Dietary Insights and Nutrition Experiences in Adults on GLP-1 Therapy - A Study on Diet Quality Changes in Adults on GLP-1 Therapy","Inclusion Criteria:\n\n* Adults aged 18 and older\n* Recently has been prescribed GLP-1 therapy for the treatment of obesity or T2DM but have not yet initiated the medication\n* Has regular access to a smartphone and internet to complete short surveys and food recalls online\n* Willing to sign informed consent.\n\nExclusion Criteria:\n\n* Already began the GLP-1 medication\n* Have medical concerns making participation unsafe",{"count":110,"type":23},"12 Weeks","The DINE-GLP1 study aims to understand how people on GLP-1 therapy change their eating habits and what kind of dietary support they need. As more people use GLP-1 medications, there's not much guidance on what they should eat, mostly just focusing on managing symptoms and cutting calories. Since these medications reduce food intake, it's important to ensure the diet is nutritious even with fewer calories to help with long-term weight control and health. Most research has looked at how the body responds to the medication and whether patients take it as prescribed, but not much is known about what patients actually experience, what they think they need, or how they could use additional support. Understanding patients' views can help create better lasting solutions. Note that this study does not provide free GLP-1 medication.",[114,498],"Obesity (Disorder)",[116,500,88,118],"Nutrition Support","2026-02-17",{"date":503,"type":39},"2026-02-19",{"date":505,"type":39},"2026-02-11",{"date":507,"type":23},"2026-12-01",{"name":45,"class":46},{"id":510,"slug":511,"hasResults":12,"nctId":512,"briefTitle":513,"officialTitle":514,"acronym":515,"eligibilityCriteria":516,"healthyVolunteers":55,"sex":18,"minAge":517,"maxAge":518,"enrollmentInfo":519,"targetDuration":4,"studyType":24,"phases":521,"briefSummary":522,"conditions":523,"keywords":527,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":532,"lastUpdatePostDateStruct":533,"startDateStruct":535,"completionDateStruct":537,"leadSponsor":539,"locationsCount":71},"100525092","reducing-metabolic-dysregulation-in-dyads-100525092","NCT06117241","Reducing Metabolic Dysregulation in Dyads","A Transdisciplinary Approach to Investigating Metabolic and Risk of Early-Onset Colorectal Cancer: A Randomized Intervention Trial in Human Dyads and Mechanistic Study in Animals","REMEDY","Individuals eligible to participate in this study will be apparently disease- free, obese (BMI ≥ 30kg\u002Fm2) AAs or EAs who have self-identified a partner who is at least 9 years old, with whom they live and who also is at least overweight. Each index patient will: 1) Be AA or EA by self-report; 2) Be ≤55 years old; 3) Have agreed to undergo colonoscopy screening and found to have ≥1 polyp(s) that place them at elevated risk for future adenomas and CRC; 4) Be free of co-morbid conditions or other factors that would limit participation in this trial; 5) Have a BMI ≥30kg\u002Fm2; 6) Be willing to commit to investing the time and effort required to participate in this trial (i.e., willing to complete all assessments and provide biological samples as specified in the consent); and 7) Have no recent antibiotic use (≤3 months). Their dyad partner needs to: 1) Be at least 9 years old; 2) Live in the same household and consumes meals together; 3) Be at least overweight; 4) Agree to all study procedures, including provision of biological samples, anthropometric measurements, and self-reported dietary and other assessments; 5) Have no recent antibiotic use (≤3 months).","9 Years","55 Years",{"count":520,"type":23},180,[83],"This study is a 6-month randomized controlled trail of diet modification designed to reduce chronic inflammation and reverse metabolic dysfunction among obese individuals with one or more polyps found at a colonoscopy screening. We also will recruit an at least overweight partner, who lives in the same household. To be eligible, participants will be apparently disease-free, obese AAs or EAs who have self-identified a partner who is at least 9 years, with whom they live and who also is at least overweight. Each index participant will: 1) Be AA or EA by self-report; 2) Be ≤55 years old; 3) Have undergone a colonoscopy screening and found to have ≥1 polyp(s); 4) Be free of co-morbid conditions or other factors that would limit participation in this trial; 5) Have a BMI ≥30kg\u002Fm2; 6) Be willing to commit to investing the time and effort required to participate in this trial (i.e., willing to complete all assessments and provide biological samples as specified in the consent); and 7) Have no recent antibiotic use. Their partner needs to: 1) Be at least 9 years old; 2) Live in the same household and consumes meals together; 3) Be at least overweight; 4) Agree to all study procedures, including provision of biological samples, body measurements, and self-reported dietary and other assessments; and 5) Have no recent antibiotic use.",[524,525,526],"Colorectal Cancer","Inflammation","Nutrition Related Cancer",[528,529,530,531],"Body Composition","Cancer","Digestive System","Microbiome","2026-01-27",{"date":534,"type":39},"2026-01-29",{"date":536,"type":39},"2023-10-17",{"date":538,"type":23},"2028-03-31",{"name":45,"class":46},{"id":541,"slug":542,"hasResults":12,"nctId":543,"briefTitle":544,"officialTitle":545,"acronym":4,"eligibilityCriteria":546,"healthyVolunteers":55,"sex":18,"minAge":547,"maxAge":4,"enrollmentInfo":548,"targetDuration":4,"studyType":24,"phases":549,"briefSummary":550,"conditions":551,"keywords":555,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":561,"startDateStruct":563,"completionDateStruct":564,"leadSponsor":566,"locationsCount":71},"100619090","church-implementation-of-a-social-support-intervention-to-increase-physical-activity-in-older-african-american-adults-100619090","NCT07340099","Church Implementation of a Social Support Intervention to Increase Physical Activity in Older African American Adults","Community-Based Participatory Research to Study Church Implementation of an Evidence-Based Social Support Intervention to Increase Physical Activity Among Older African American Adults","Inclusion Criteria:\n\n* Member of participating church (Charleston or Columbia Districts of the 7th Episcopal District of the AME church) or is in larger neighborhood and able to attend\n* Aged 50 years and older\n* Agrees to participate in in-person walking group sessions\n* Not planning to move in the next year from a location that would make study visits difficult\n\nExclusion Criteria:\n\n* No contraindications to exercise, as determined by the PAR-Q","50 Years",{"count":81,"type":23},[83],"Many effective interventions or programs are never put into practice. This quasi-experimental study will partner with AME churches in two areas of South Carolina to study how an evidence-based program is put into place by the church. The program, Walk Your Heart to Health, will include training in how churches can modify their practices to support physical activity and healthy eating. Over the five-year study, the investgiators will examine factors that predict the success of putting the program into place, things that help and get in the way of putting the program into place, and how the program can be scaled up to reach even more churches. The investigators will also examine the effect of the program (pre- to post-changes) on walking group member outcomes (physical activity and social cohesion). The investigators expect to work with approximately 26 AME churches for this study.",[552,553,554],"Healthy Participants","Chronic Diseases in Older Adults","Chronic Disease Prevention",[308,556,557,558,559],"walking","health promotion","chronic disease prevention","older adults","2026-01-05",{"date":562,"type":39},"2026-01-14",{"date":335,"type":23},{"date":565,"type":23},"2029-09-29",{"name":45,"class":46},{"id":568,"slug":569,"hasResults":12,"nctId":570,"briefTitle":571,"officialTitle":572,"acronym":4,"eligibilityCriteria":573,"healthyVolunteers":55,"sex":18,"minAge":19,"maxAge":574,"enrollmentInfo":575,"targetDuration":4,"studyType":24,"phases":577,"briefSummary":578,"conditions":579,"keywords":586,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":560,"lastUpdatePostDateStruct":593,"startDateStruct":594,"completionDateStruct":596,"leadSponsor":598,"locationsCount":71},"100619092","pistachio-snacking-and-metabolic-flexibility-100619092","NCT07340125","Pistachio Snacking and Metabolic Flexibility","Effects of Pistachio Snacking on Metabolic Flexibility in Healthy Overweight and Obese Adults","Inclusion Criteria:\n\n* Males and Females\n* Age: 25-45 years\n* Overweight or obese (BMI=25.0-34.9 kg\u002Fm²)\n* Poor sleep quality (Pittsburgh Sleep Quality Index ≥ 5)\n* Healthy (no diagnosed metabolic, cardiovascular, sleep, or other health condition that may significantly alter metabolism, sleep, or ability to participate in the exercise test)\n* Not meeting weekly physical activity recommendations (\\\u003C150 min moderate-intensity exercise, \\\u003C75 minutes of vigorous-intensity exercise, and \\\u003C2 days of strength training)\n* Not following a diet that is restrictive or eliminates certain food group\u002Ftypes\n\nExclusion Criteria:\n\n* Allergies to nuts, especially tree nuts\n* Has a pacemaker\n* Following a diet that is restrictive or eliminates certain food group\u002Ftypes\n* Self-repoted health or disease state that may influence study outcomes, including known metabolic or endocrine disorder (e.g. prediabetes, type 1 or type 2 diabetes, or polycystic ovary syndrome), cardiovascular diseases, neuromuscular disorders, musculoskeletal disorders; current or recent history of cancer\u002Fcancer treatment (within the past year)\n* History of gastrointestinal surgery, hysterectomy\n* For women: pregnant or thinking of becoming pregnant during the time of participation, pregnant within the last year, currently breastfeeding, or known to be perimenopausal","45 Years",{"count":576,"type":23},60,[83],"The purpose of this study is to evaluate the effects of pistachio snacking on metabolic flexibility (at rest, during exercise, and in post-exercise recovery) in healthy overweight and obese adults. Secondary goals include evaluating effects on changes in diet quality, sleep characteristics, physical activity, and hormonal health in women. In randomized order, participants will complete four days of pistachio snacking and four days of normal dietary habits (control). For both conditions, primary outcomes of resting substrate metabolism, metabolic flexibility during exercise, and post-exercise substrate metabolism will be measured pre-post intervention via indirect calorimetry. Secondary outcome of diet quality (kcal, carb, fat, protein) will be measured pre-post intervention via diet log. Exploratory outcomes of daily physical activity (steps, intensity), nightly sleep characteristics (quantity, quality, latency, efficiency), and daytime sleepiness and hunger.",[580,581,582,583,584,552,585],"Overweight (BMI > 25)","Obese But Otherwise Healthy Participants","Overweight or Obese","Obese Patients (BMI ≥ 30 kg\u002Fm²)","Poor Sleep Quality","Physically Inactive",[587,588,589,590,591,592],"Pistachio","Tree Nuts","metabolic flexibility","metabolism","diet quality","snacking",{"date":562,"type":39},{"date":595,"type":39},"2025-09-01",{"date":597,"type":23},"2026-12-31",{"name":45,"class":46},{"id":600,"slug":601,"hasResults":12,"nctId":602,"briefTitle":603,"officialTitle":604,"acronym":605,"eligibilityCriteria":606,"healthyVolunteers":55,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":607,"targetDuration":4,"studyType":24,"phases":609,"briefSummary":610,"conditions":611,"keywords":613,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":617,"lastUpdatePostDateStruct":618,"startDateStruct":620,"completionDateStruct":622,"leadSponsor":624,"locationsCount":71},"100524225","optimal-digital-weight-loss-treatment-for-rural-individuals-100524225","NCT06105957","Optimal Digital Weight Loss Treatment for Rural Individuals","Addressing Rural Health Disparities by Optimizing \"High Touch\" Intervention Components in Digital Obesity Treatment","iREACH","Inclusion Criteria:\n\n* have a body mass index \\[BMI\\] \\> 25-55 kg\u002Fm2;\n\n  * home address in a zip code classified as non-urban; classification of an individual as living in a non-urban area will be determined by meeting any one of the following criteria: (1) having a home address corresponding to a Rural-Urban Commuting Area \\[RUCA\\] code of 4-10); (2) qualifying as rural under the Centers for Medicare and Medicaid Services Rural Health Clinic Program based on the 2010 or 2020 Census Bureau data; or (3) meeting the definition of rural from the Federal Office of Rural Health Policy;\n  * have no physical limitations that prevent walking at a moderate pace for at least 10 minutes without stopping;\n  * be able to provide informed consent;\n  * have access to a smartphone and a computer or tablet with a video camera and stable access to the Internet (at home or work or some other stable source of access);\n  * complete all screening and baseline questionnaires and activities.\n\nExclusion Criteria:\n\n* only one member of a household may participate concurrently.\n* currently participating in another weight loss program, taking a weight loss medication, have a history of bariatric surgery, or lost ≥ 10 pounds during the past 6-months;\n* are pregnant, lactating, less than 6 months post-partum, or plan to become pregnant during the time frame of the investigation;\n* report a medical condition that would affect the safety and\u002For efficacy of a weight management program involving diet and physical activity (e.g., uncontrolled heart condition, dementia, bulimia nervosa or binge eating disorder, or other significant psychiatric problems);\n* or report conditions that in the judgment of the one of the Principal Investigators (MPIs) would render them unlikely to be able to independently follow the intervention protocol for 6 months, including conditions which might comprise their ability to engage independently with the intervention website materials, provide self-monitoring information on a smartphone app, attend Zoom video group or individual sessions at the available times (if randomized to receive these treatment components), and complete online questionnaires.",{"count":608,"type":23},616,[83],"Over 130 million adults in the US experience overweight and obesity, and rural communities experience significantly higher rates of obesity and related chronic diseases. Although lifestyle interventions successfully produce clinically significant weight losses, the availability of weight management programs is limited in rural areas. Digital interventions offer an attractive alternative for delivering lifestyle programs to rural populations. However, in-person behavioral obesity treatment programs achieve better weight losses than digital programs, likely because in-person programs typically include personnel-intensive \"high touch\" treatment components. Some studies indicate that having a human \"behind the curtain\" of a digital program through emailed feedback or with the addition of online group sessions can significantly increase weight loss. Therefore, the aims of this study are to increase the public health impact of digital obesity treatment for rural populations by simultaneously investigating 3 \"high touch\" intervention components. The investigators will conduct a highly efficient experiment with participants residing in non-urban areas recruited online from across the United States. Participants (N=616; 22% racial\u002Fethnic minority; 40% male) will be randomized to: (1) weekly facilitated synchronous group video sessions (yes vs. no); (2) type of self-monitoring feedback received (counselor-crafted vs. pre-scripted); and (3) individual coaching calls (yes vs. no). These components will be layered onto our 24-week evidence-based, interactive digital weight loss program delivered to groups of eligible individuals. Based on the results of the experiment, The investigators will identify an optimized program in which each component (or combination of components) contributes meaningfully (at least 1.5 kg greater weight loss at 6-months) to enhanced weight loss. The investigators will also exploratory analyses of weight trajectories 6-months post-treatment (i.e., at 12-months) to elucidate extended impact of the specific components on weight control. Ultimately, this research will set the stage for confirming the most promising digital behavioral weight loss intervention that can be used without geographic borders to reduce obesity rates among rural residents and provide the evidence needed to establish best practice policies for broadly effective digital approaches to weight control.",[612],"Overweight and Obesity",[614,615,616],"behavioral weight control","weight management","online weight loss program","2025-12-21",{"date":619,"type":39},"2025-12-23",{"date":621,"type":39},"2024-01-03",{"date":623,"type":23},"2027-12-31",{"name":45,"class":46},{"id":626,"slug":627,"hasResults":12,"nctId":628,"briefTitle":629,"officialTitle":630,"acronym":631,"eligibilityCriteria":632,"healthyVolunteers":12,"sex":244,"minAge":633,"maxAge":4,"enrollmentInfo":634,"targetDuration":4,"studyType":24,"phases":636,"briefSummary":637,"conditions":638,"keywords":643,"overallStatus":154,"whyStopped":4,"lastUpdateSubmitDate":653,"lastUpdatePostDateStruct":654,"startDateStruct":656,"completionDateStruct":658,"leadSponsor":660,"locationsCount":71},"100517959","leveraging-community-health-workers-and-a-digital-health-system-to-improve-the-timeliness-of-child-well-visits-100517959","NCT06024317","Leveraging Community Health Workers and a Digital Health System to Improve the Timeliness of Child Well Visits","Leveraging Community Health Workers and a Responsive Digital Health System to Improve Rates and Timeliness of Child Well Visits in the First Year of Life","MINT-II\u002FHKW","Inclusion Criteria for the Cross-sectional sample:\n\n* mothers of children ages 12-23 months\n* residing in the sampling area\n\nInclusion Criteria for the Longitudinal sample:\n\n* pregnant women in their last trimester of pregnancy\n* residing in the sampling area\n* expected to reside in the sampling area until the child reaches age 1 year\n\nExclusion Criteria:\n\n* Women who are not living in catchment areas of participating health facilities (which routinely provide maternal and child health services). Facilities must be operational, must have at least 2 community health workers, and must have reported at least 100 pregnancies or births in the year prior to study implementation.)","15 Years",{"count":635,"type":23},800,[83],"The goal of this cluster-randomized type 1 effectiveness implementation hybrid trial is to evaluate whether a community health worker led, integrated digital health intervention (Huduma Kwa Wakati; \"Timely Services\" in Kiswahili) can improve rates of timely well visits and receipt of key recommended preventive interventions among children in their first year of life. The hypothesis is that Huduma Kwa Wakati will improve the timeliness and rates of completion of child well visits and receipt of recommended preventive services before age 1 year, compared to the standard of care. Researchers will compare outcomes among children enrolled from intervention clusters and no-intervention comparison clusters. Outcomes will also be compared to a cross-sectional retrospective comparison sample. This study will address the lack of rigorous evidence on the effectiveness of a community-based digital health intervention for promoting rates and timeliness of preventive service receipt among children from sub-Saharan Africa, and identify implementation strategies to facilitate the deployment of integrated community-based digital health interventions in low- and middle-income country settings.",[639,640,641,642],"Short Message Service (SMS)","Incentives","Knowledge, Attitudes, Practice","Preventive Services",[644,645,646,647,648,649,650,651,652],"Timeliness","Digital Health","Community Health Workers","Tanzania","Low and middle-income country","SMS reminder","Conditional incentive","Preventive services","Children","2025-12-18",{"date":655,"type":39},"2025-12-26",{"date":657,"type":23},"2026-03-01",{"date":659,"type":23},"2027-07-31",{"name":45,"class":46},{"id":662,"slug":663,"hasResults":12,"nctId":664,"briefTitle":665,"officialTitle":666,"acronym":667,"eligibilityCriteria":668,"healthyVolunteers":55,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":669,"targetDuration":4,"studyType":24,"phases":670,"briefSummary":671,"conditions":672,"keywords":673,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":680,"lastUpdatePostDateStruct":681,"startDateStruct":683,"completionDateStruct":685,"leadSponsor":687,"locationsCount":71},"100566985","mobile-supportive-teams-for-reinforcing-increased-daily-exercise-study-100566985","NCT06662292","Mobile Supportive Teams for Reinforcing Increased Daily Exercise Study","Using Existing Social Ties to Promote Physical Activity: Effects of Digitally Delivered Team Social Support Training","STRIDES","Inclusion Criteria:\n\nParticipants must:\n\n* be at least 18 years of age\n* be insufficiently physically active (\\\u003C 150 minutes per week of moderate-intensity equivalent aerobic physical activity as measured by waist-worn accelerometer (research grade physical activity measurement device) - i.e., sum of time spent in minutes of moderate-intensity activity plus twice the minutes spent in vigorous-intensity activity \\\u003C 150 minutes per week)\n* be part of a self-selected team of 3-8 individuals each of whom also meet all other eligibility criteria (members of the same household are only eligible to participate if they are on the same team - limit one team per household)\n* have access to a smartphone (Android or iphone operating system-based) with an internet connection\n* report being able to walk at least ¼ mile without stopping\n* be able to provide informed consent\n* complete all screening and baseline questionnaires and activities\n\nExclusion Criteria:\n\n* participating in another physical activity study or program\n* are pregnant, breastfeeding, less than 6 months post-partum, or plan to become pregnant during the time frame of the investigation\n* report a medical condition that would affect the safety and\u002For efficacy of a physical activity program (e.g., terminal illness; uncontrolled heart condition, dementia, bulimia nervosa or binge eating disorder, other significant psychiatric problems, or use of insulin)\n* report conditions that in the judgment of the Principal Investigator would render them unlikely to be able to independently follow the intervention protocol for 3 months, including conditions which might compromise their ability to engage independently with the intervention website materials and wearable physical activity tracker, as well as complete online questionnaires and adhere to wearing an accelerometer",{"count":81,"type":23},[83],"The goal of this research is to examine the addition of a digitally delivered social support training approach to an existing digital program designed to promote a physically active lifestyle among self-selected teams of adults who are not meeting physical activity guidelines. The main aims are to:\n\n1. Determine if the social support training intervention promotes significantly greater changes in moderate-to-vigorous intensity aerobic physical activity (such as a brisk walk) as measured by an accelerometer (research grade physical activity measurement device) at 3 months compared to the same intervention without social support training among self-selected teams of adults who are not meeting the physical activity guidelines.\n2. Determine if the social support training intervention promotes significantly greater changes in social support, motivation, accountability, and autonomy social support (free from excessive control and encouraging one's free will) at 3 months and 12 months compared to the same intervention without social support training.\n3. Determine if the social support training intervention promotes significantly greater changes in moderate-to-vigorous intensity aerobic physical activity as measured by an accelerometer at 12 months compared to the same intervention without social support training.\n4. Explore whether social support mediates increased and sustained moderate-to-vigorous intensity aerobic physical activity among the entire sample of participants.",[362],[308,176,674,675,676,677,678,679],"adults","social support","smartphone","electronic health","mobile health","teams","2025-10-13",{"date":682,"type":39},"2025-10-15",{"date":684,"type":39},"2025-08-28",{"date":686,"type":23},"2028-11-01",{"name":45,"class":46},{"id":689,"slug":690,"hasResults":12,"nctId":691,"briefTitle":692,"officialTitle":693,"acronym":4,"eligibilityCriteria":694,"healthyVolunteers":55,"sex":18,"minAge":107,"maxAge":4,"enrollmentInfo":695,"targetDuration":4,"studyType":24,"phases":697,"briefSummary":698,"conditions":699,"keywords":704,"overallStatus":35,"whyStopped":4,"lastUpdateSubmitDate":711,"lastUpdatePostDateStruct":712,"startDateStruct":714,"completionDateStruct":716,"leadSponsor":718,"locationsCount":71},"100467687","improving-the-collaborative-health-of-minority-covid-19-survivor-and-carepartner-dyads-100467687","NCT05370014","Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads","Improving the Collaborative Health of Minority COVID-19 Survivor and Carepartner Dyads Through Interventions Targeting Social and Structural Health Inequities.","Inclusion Criteria:\n\nCOVID-19 survivor inclusion criteria\n\n* African American\n* Male and female\n* Living in a Medically Underserved Area and\u002For a designated rural area of South Carolina\n* ≥ 18 years and above\n* A history of a COVID-19-associated hospitalization, ER or Urgent Care visit since March 11th, 2020\n* A previous diagnosis of one or more of the following conditions: type 2 diabetes, hypertension, cardiovascular disease, chronic kidney disease, or stroke (\\>3 months)\n\n  -Carepartner inclusion criteria\n* Male and female\n* ≥ 18 years and above\n* Must live on the same property or community, preferably within a 40-mile radius of the survivor\n* Primarily responsible for care provision and\u002For care\u002Fsocial support in the home (i.e., is not paid for services)\n\nExclusion Criteria:\n\n* Survivor and Carepartner exclusion criteria • Enrolled in related clinical trials",{"count":696,"type":23},500,[83],"This study tests the efficacy of a dyadic intervention to mitigate the adverse health consequences of severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2 )(COVID-19) in African American (AA) adults with pre-existing chronic health conditions and their informal carepartners (IC). Socioeconomically disadvantaged, older, and Black\u002FAfrican American from rural regions are burdened with greater rates of chronic diseases such as diabetes, hypertension, chronic kidney disease, cardiovascular disease, and stroke.",[700,701,702,703,360,34],"SARS- CoV-2","Cardiovascular Diseases","Chronic Kidney Diseases","Diabetes Mellitus, Type 2",[705,706,707,708,709,710],"health inequities","rural","Black\u002FAfrican American","dyads","structural determinants of health","quality of life","2025-05-13",{"date":713,"type":39},"2025-05-16",{"date":715,"type":39},"2023-01-03",{"date":717,"type":23},"2026-06-30",{"name":45,"class":46},""]