[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Southern Denmark\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":693},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,33,0,25,[9,45,75,101,127,151,180,204,231,253,293,325,353,376,397,423,449,488,512,532,561,584,609,643,669],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642989","impact-and-experiences-of-using-decisions-aids-in-outpatient-mental-health-100642989",false,"NCT07637747","Impact and Experiences of Using Decisions Aids in Outpatient Mental Health.","DAN-SHARE. Impact and Experiences of Using Decisions Aids in Hospital Outpatient Mental Health Settings. A Mixed Methods Study on Shared Decision-making Practice in the Danish Mental Healthcare","Inclusion Criteria:\n\n* Age ≥ 18 years\n* In treatment for a mental health disorder in one of the participating settings of the study\n\nExclusion Criteria:\n\n* Unable to understand Danish language\n* Unable to provide verbal and written informed consent\n* Diagnosed with cognitive impairment or dementia","ALL","18 Years",{"count":20,"type":21},62,"ESTIMATED","INTERVENTIONAL",[24],"NA","DAN-SHARE is a study on shared decision-making (SDM) in Danish mental healthcare that investigates the impact of a decision aid, the Decision Helper™, on patient involvement in treatment decision-making in hospital outpatient mental health settings. The study also explores patients' and healthcare professionals' understanding and experiences of using the Decision Helper™ as part of decision-making practice in mental healthcare.",[27],"Shared Decision Making",[29,30,31],"Mental health","Share decision making","decision aids","RECRUITING","2026-06-09",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":36},"2026-04-15",{"date":40,"type":21},"2027-12-31",{"name":42,"class":43},"University of Southern Denmark","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":12,"sex":17,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":4,"studyType":22,"phases":56,"briefSummary":59,"conditions":60,"keywords":64,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":68,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":4},"100642907","phase-1-repeated-injections-of-adipose-derived-stem-cells-in-rotator-cuff-tears-100642907","NCT07592936","Repeated Injections of Adipose-derived Stem Cells in Rotator Cuff Tears","Effects and Benefits of Repeated Injections of Adipose-derived Stem Cells on Shoulder Function in Rotator Cuff Tears: A Randomized Controlled Study","Inclusion Criteria:\n\n* Clinical signs and symptoms compatible with a traumatic RCT\n* MR verified supraspinatus tear\n* Reparable lesion with tendon retraction \\\u003C 2 cm.\n* Fatty infiltration level 0-2 according to Fuchs or out of 5 based on Goutalliers classification\n* No history of inflammatory disease\n* Negative infectious disease marker tests Signed consent to the study\n\nExclusion Criteria:\n\n* Former surgery in the affected shoulder\n* Signs of infection\n* Immunosuppression (due to clinical condition or medical therapy)\n* Any malignancy within 5 years prior to screening\n* Previous radiotherapy to the shoulder\n* BMI under 18\n* BMI above 35\n* Allergy to antibiotics such as penicillin\n* Coagulopathy","30 Years","69 Years",{"count":55,"type":21},30,[57,58],"PHASE1","PHASE2","The aim of the project is to investigate whether repeated implantations of micro-fragmented adipose tissue (MFAT), into the shoulder muscle can improve the outcome of standard surgical treatment for rotator cuff tears (RCT). The investigators hypothesize that combining surgery with repeated implantations of micro-fragmented adipose tissue (MFAT) into the muscle provides a more effective treatment for patients with rotator cuff tears compared to standard surgical treatment. The result would be better outcomes such as improved shoulder functioning and reduced pain.",[61,62,63],"Rotator Cuff Tears","Rotator Cuff Injuries","Stem Cells",[65,66],"Adipose derived stem cells","ADSC","NOT_YET_RECRUITING",{"date":69,"type":36},"2026-06-12",{"date":71,"type":21},"2026-08",{"date":73,"type":21},"2028-08",{"name":42,"class":43},{"id":76,"slug":77,"hasResults":12,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":4,"eligibilityCriteria":81,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":82,"targetDuration":4,"studyType":22,"phases":84,"briefSummary":85,"conditions":86,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":44},"100559941","video-call-assisted-assessment-of-acute-stroke-100559941","NCT06570681","Video Call Assisted Assessment of Acute Stroke","Video Call Assisted Assessment of Acute Stroke in Addition to Stroke Scales in a Prehospital Setting: A Cluster Randomised Controlled Trial","Inclusion Criteria:\n\n* Suspected stroke within 24 hours from onset (confirmed with Prehospital Stroke 1 decision tool)\n* Age \\>18 years\n\nExclusion Criteria:\n\n* Suspected stroke more than 24 hours ago\n* In-hospital stroke or private transport to hospital\n* Unconsciousness defined as Glasgow Coma Score (GCS) ≤ 8 (as they cannot be rated)",{"count":83,"type":21},512,[24],"This study aims to investigate whether a live stream video between the on-call neurologist and the emergency medical technicians can increase feasibility and performance of symptom-based prehospital stroke scales.",[87,88,89,90,91,92],"Stroke","Cerebrovascular Disorders","Brain Diseases","Nervous System Diseases","Vascular Diseases","Central Nervous System Diseases","2026-05-11",{"date":95,"type":36},"2026-05-14",{"date":97,"type":36},"2024-05-27",{"date":99,"type":21},"2026-06-03",{"name":42,"class":43},{"id":102,"slug":103,"hasResults":12,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":4,"eligibilityCriteria":107,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":109,"targetDuration":4,"studyType":22,"phases":111,"briefSummary":112,"conditions":113,"keywords":116,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":121,"startDateStruct":122,"completionDateStruct":124,"leadSponsor":126,"locationsCount":44},"100490149","influence-of-nociception-level-monitor-nol-guided-analgesic-delivery-on-robot-assisted-colorectal-surgery-100490149","NCT05662371","Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on Robot-assisted Colorectal Surgery","Influence of Nociception Level Monitor (NOL) Guided Analgesic Delivery on the Perioperative Course, Quality of Recovery and Hospital Stay in Robot-assisted Colorectal Surgery","Inclusion Criteria:\n\n* American Society of Anaesthesiologists score III-IV\n* Scheduled for elective major robot-assisted colorectal surgeries\n\nExclusion Criteria:\n\n* Inability to give informed consent\n* planned spinal or epidural anaesthesia\n* all forms of regional anaesthesia, including wound infiltration\n* nonelective procedures\n* pregnancy or lactation\n* atrial fibrillation","80 Years",{"count":110,"type":21},60,[24],"Being relatively new, the NOL monitor may offer interesting observations in perioperative nociception levels and appropriate analgesic consumption in diverse surgeries, including robot-assisted surgery. These observations may supplement the current efforts towards further advantages in rapid restitution. Therefore, the investigators planned a trial where intra-operative analgesics were guided using an NOL monitor to study if intra-operative NOL guidance influences peri-operative analgesic consumption, postoperative length of stay and quality of recovery of patients subjected for robot-assisted surgery.",[114,115],"Opioid Use, Unspecified","Pain, Postoperative",[117,118,119,120],"Nociception,","robotic surgery,","opioids,","postoperative recovery",{"date":95,"type":36},{"date":123,"type":36},"2023-08-01",{"date":125,"type":21},"2027-03-31",{"name":42,"class":43},{"id":128,"slug":129,"hasResults":12,"nctId":130,"briefTitle":131,"officialTitle":131,"acronym":132,"eligibilityCriteria":133,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":134,"enrollmentInfo":135,"targetDuration":4,"studyType":22,"phases":137,"briefSummary":139,"conditions":140,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":142,"lastUpdatePostDateStruct":143,"startDateStruct":145,"completionDateStruct":147,"leadSponsor":149,"locationsCount":150},"100459519","phase-3-fast-acute-sedation-at-intensive-care-vs-high-dose-iv-anti-seizure-medication-for-treatment-of-non-convulsive-status-epilepticus-fast-trial-100459519","NCT05263674","Fast Acute Sedation at Intensive Care vs. High-dose i.v. Anti-seizure Medication for Treatment of Non-convulsive Status Epilepticus (FAST-trial)","FAST","Inclusion Criteria:\n\n* Adult patients (older than 18 years) with EEG-verified NCSE, according to the Salzburg criteria, who have not responded to appropriate treatment with benzodiazepines and at least one 2nd line i.v. anti-seizure medication according to the current Danish national neurological treatment guidelines (Levetiracetam, Fosfenytoin or Valproate).\n\nExclusion Criteria:\n\n* patients with epilepticus status due to acute neuroinfection (e.g. bacterial meningitis or viral encephalitis)\n* acute traumatic or spontaneous intracranial hemorrhage\n* suspicion of cerebral anoxia \u002F hypoxia \u002F hypoglycemia \u002F epileptic encephalopathy\n* contraindications to anti-seizure medication defined in the protocol\n* contraindications to anesthesia treatment in intensive care\n* focal motor status epilepticus without relevant conscious influence (Glasgow Coma Scale\\> 13)\n* known epileptic encephalopathy\n* Clinical need for acute intubation","120 Years",{"count":136,"type":21},140,[138],"PHASE3","This open-label, randomized multicenter trial aims at clarifying the standard of care of patients with non-convulsive status epilepticus not responding to treatment with benzodiazepines and at least one high-dose intra venous anti-seizure medication.",[141],"Non-Convulsive Status Epilepticus","2026-05-01",{"date":144,"type":36},"2026-05-04",{"date":146,"type":36},"2022-02-07",{"date":148,"type":21},"2028-12-31",{"name":42,"class":43},5,{"id":152,"slug":153,"hasResults":12,"nctId":154,"briefTitle":155,"officialTitle":156,"acronym":157,"eligibilityCriteria":158,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":159,"targetDuration":4,"studyType":22,"phases":160,"briefSummary":161,"conditions":162,"keywords":166,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":172,"startDateStruct":174,"completionDateStruct":176,"leadSponsor":178,"locationsCount":179},"100636728","online-personalized-psychological-intervention-for-patients-with-heart-disease-and-depression-or-anxiety-my-choice-100636728","NCT07569458","Online Personalized Psychological Intervention for Patients With Heart Disease and Depression or Anxiety (MY-CHOICE)","Online Personalized and Patient-preferred Comprehensive Intervention for Patients With Heart Disease and Depression or Anxiety (MY-CHOICE)","MY-CHOICE","Inclusion Criteria:\n\n* ischemic heart disease (diagnostic codes I20-I25),\n* referred for CR with a positive screen for depression and\u002For anxiety with the Hospital Anxiety and Depression Scale (HADS ≥ 8)\n* access to and ability to use a computer or tablet\n* proficient in the Danish language\n\nExclusion Criteria:\n\n* Severe psychiatric disorder (i.e., borderline disorder, schizophrenia or bipolar disorder) that requires psychiatric care\n* severe cognitive difficulties (e.g., severe brain damage, mental retardation, or dementia) that will prevent patients from participating\n* endorsement of suicidal ideation with suicidal thoughts (purpose designed questions) that cannot be handled in the intervention\n* participation in other intervention studies focused (unless they are clinical studies)\n* seeing a psychologist or mental health professional for the treatment of anxiety and depression\n* not being able or willing to spend 3-4 hours on the intervention each week\n* experiencing significant life stressors that hinder adherence to the MY-CHOICE treatment",{"count":55,"type":21},[24],"The goal of this feasibility study is to assess if the personalised online psychological intervention MY-CHOICE is acceptable to adults with ischemic heart disease and anxiety or depression. It will also examine the reasons for drop-out. The main questions the study aims to answer are:\n\nHow many participants complete the intervention and what are the reasons for drop-out. And what are the pre-post change scores on anxiety and depression.\n\nParticipants will:\n\nComplete the MY-CHOICE intervention consisting of 6-12 weeks with online modules on various topics based on individual needs in combination with video- or telephone calls with a therapist (psychologist or a trained master student in Psychology) on a need-to basis.\n\nAnswer a set of questionnaires pre and post intervention. Participate in a brief interview post intervention.",[163,164,165],"Ischemic Heart Disease (IHD)","Anxiety","Depression",[167,168,169,170],"online intervention","psychological intervention","ischemic heart disease","treatment of anxiety and depression","2026-04-28",{"date":173,"type":36},"2026-05-06",{"date":175,"type":36},"2025-07-04",{"date":177,"type":21},"2026-10",{"name":42,"class":43},3,{"id":181,"slug":182,"hasResults":12,"nctId":183,"briefTitle":184,"officialTitle":185,"acronym":4,"eligibilityCriteria":186,"healthyVolunteers":187,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":188,"targetDuration":4,"studyType":22,"phases":190,"briefSummary":191,"conditions":192,"keywords":194,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":196,"startDateStruct":198,"completionDateStruct":200,"leadSponsor":202,"locationsCount":203},"100616476","the-effect-of-long-term-daily-stimulation-of-the-brain-with-pulsed-electromagnetic-fields-on-parkinsons-disease-100616476","NCT07306104","The Effect of Long-term Daily Stimulation of the Brain With Pulsed Electromagnetic Fields on Parkinsons Disease","The Effect of Long-term Treatment of Parkinson's Disease With T-PEMF","Intervention Groups\n\nInclusion Criteria:\n\n* Diagnosed with idiopathic Parkinson's disease\n* The participant must be able to understand, accept, and complete the planned procedures\n* Parkinson's symptoms in the medicated state must correspond to Hoehn \\& Yahr stage 1 or 2\n* Mini Mental-State Examination score \\> 22\n\nExclusion Criteria:\n\n* Cancer in the brain, neck, or head area\n* Presence of active medical implants\n* Epilepsy\n* Alcoholism\n* Substance abuse\n* Open wound on the scalp\n* Severe psychopathological disorders\n* Pregnancy\n* Changes in pharmacological anti-Parkinson medication within the last 6 weeks prior to the start of T-PEMF treatment\n* Anticoagulant treatment with Marevan, Marcoumar, Pradaxa, Eliquis, Xarelto, Lixiana, Novostan, Fragmin, or Innohep\n* Neurological disease other than Parkinson's disease\n* Previous stroke\n* Reduced motor function caused by conditions other than Parkinson's disease\n\nControl Group with Parkinson's Disease\n\nInclusion Criteria:\n\n* Diagnosed with idiopathic Parkinson's disease\n* The patient must be able to understand, accept, and complete the planned procedures\n* Parkinson's symptoms in the medicated state must correspond to Hoehn \\& Yahr stage 1 or 2\n* Mini Mental-State Examination score \\> 22\n\nExclusion Criteria:\n\n* Neurological disease other than Parkinson's disease\n* Reduced motor function caused by conditions other than Parkinson's disease\n\nHealthy Reference Group:\n\nInclusion Criteria:\n\n-The patient must be able to understand, accept, and complete the planned procedures\n\nExclusion Criteria:\n\n* Neurological disease\n* Reduced motor function caused by condition",true,{"count":189,"type":21},90,[24],"The goal of this clinical trial is to learn to what extent daily stimulation of the brain with transcranial pulsed electromagnetic fields (T-PEMF) works to treat persons with Parkinson's Disease. The main questions it aims to answer are:\n\n* How does 6 months of daily treatment (30 minutes\u002Fday) with T-PEMF affects neuro-mechanical and molecular biological factors compared with placebo treatment in persons with Parkinson's disease?\n* How does 12 months of daily treatment (30 minutes\u002Fday) with T-PEMF affects neuro-mechanical and molecular biological factors in persons with Parkinson's disease an does 12 months of T-PEMF alters the need for medication intake?\n\nThe neuro-mechanical outcomes are compared with the \"natural\" progression of the disease as well as with a healthy reference group. Furthermore, it will be examined whether 12 months of T-PEMF treatment alters the need for medication intake.\n\nParticipants in the intervention group will:\n\n* receive one 30 min treatment session daily for 12 months\n* receive either T-PEMF or sham treatment for the first 6 months\n* receive active T-PEMF treatment the last 6 months\n* visit for tests before treatment initiation, after 6 months of treatment and after 12 months of treatment.",[193],"PARKINSON DISEASE (Disorder)",[195],"T-PEMF",{"date":197,"type":36},"2026-04-29",{"date":199,"type":36},"2026-02-16",{"date":201,"type":21},"2028-01",{"name":42,"class":43},2,{"id":205,"slug":206,"hasResults":12,"nctId":207,"briefTitle":208,"officialTitle":209,"acronym":210,"eligibilityCriteria":211,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":212,"enrollmentInfo":213,"targetDuration":4,"studyType":22,"phases":214,"briefSummary":215,"conditions":216,"keywords":220,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":171,"lastUpdatePostDateStruct":225,"startDateStruct":226,"completionDateStruct":228,"leadSponsor":230,"locationsCount":203},"100537405","exercise-in-patients-with-hypermobile-joints-and-knee-pain-100537405","NCT06277401","Exercise in Patients With Hypermobile Joints and Knee Pain","High-load Resistance Training Compared With Usual Care for Treatment of Painful Knee Joint Hypermobility in Young Adults: A Randomised Controlled Trial (the HIPEr-Knee Study)","HIPEr-Knee","Inclusion criteria\n\n* Persistent knee pain for ≥ 3 months (self-reported)\n* Knee pain ≥ 30mm during the last week using a 0-100 mm visual analogue scale (VAS; 0=no pain and 100=worst imaginable pain) (self-reported)\n* Generalised joint hypermobility assessed with the Five-Part Hypermobility Questionnaire (positive ≥ 2\u002F5) (self-reported)\n* Local knee joint hypermobility using the passive hyperextension of the knee in standing (positive \\> 10 degrees of hyperextension) and confirmed in supine lying (heel resting on 20 cm high block on the bench surface), with passive knee hyperextension (positive \\> 10 degrees) (objectively measured)\n\nExclusion criteria\n\n* Diagnosed with patellar tendinopathy\n* Pregnancy or childbirth within the past year (due to increased levels of relaxin that could affect joint stability)\n* Knee surgery within the past year\n* Participation in regular structured resistance training within the past six months\n* Inability to speak and understand Danish.\n* All types of Ehlers-Danlos syndrome\n* Other heritable connective tissue disorders such as Marfan syndrome, osteogenesis imperfecta, Loeys-Dietz syndrome, Stickler syndrome, skeletal dysplasias\n* Autoimmune rheumatic connective tissue disorders such as lupus, rheumatoid arthritis; Chromosomal conditions such as Fragile X syndrome, Kabuki syndrome, Down syndrome\n* Neuromuscular disorders that can cause joints to become unstable, such as multiple sclerosis","45 Years",{"count":189,"type":21},[24],"Pain associated with knee joint hypermobility is common in the adult population, but evidence on treatment is sparse. This study investigates if high-load resistance training is superior to usual care in improving activity-related pain in young patients (18-45 years) with hypermobile joints and knee pain.",[217,218,219],"Hypermobility, Joint","Hypermobility Syndrome","Knee Discomfort",[221,222,223,224],"Hypermobility","Knee pain","Treatment","Randomised controlled trial",{"date":197,"type":36},{"date":227,"type":36},"2024-02-21",{"date":229,"type":21},"2027-12",{"name":42,"class":43},{"id":232,"slug":233,"hasResults":12,"nctId":234,"briefTitle":235,"officialTitle":236,"acronym":237,"eligibilityCriteria":238,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":239,"targetDuration":4,"studyType":22,"phases":240,"briefSummary":241,"conditions":242,"keywords":244,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":248,"completionDateStruct":250,"leadSponsor":252,"locationsCount":4},"100635773","testing-the-feasibility-of-balance-activity-quality-of-life-and-social-equity-balanse-an-activity--and-resource-oriented-rehabilitation-and-palliative-care-intervention-for-people-with-cancer-100635773","NCT07557043","Testing the Feasibility of Balance, Activity, Quality of Life and Social Equity (BALanSE): An Activity- and Resource-oriented Rehabilitation and Palliative Care Intervention for People With Cancer","Testing the Feasibility of Balance, Activity, Quality of Life and Social Equity (BALanSE): An Activity- and Resource-oriented Rehabilitation and Palliative Care Intervention for People With Cancer - Protocol for a Feasibility Study","BALanSE","Inclusion Criteria:\n\n* Adult (≥ 18 years) and residing in their own home.\n* Diagnosed with cancer.\n* Referred to a §119 in the Danish Health Act, which concerns preventive and health-promoting services.\n* Experiences a need for support to manage everyday occupations.\n* Is able to participate in the BALanSE intervention and willing to complete questionnaires and participate in interviews.\n* Must be independent concerning personal occupations of daily living (personal care, dressing and eating)\n* Residence in Odense municipality, Denmark\n* Speaks and understands the Danish language\n\nExclusion Criteria:\n\n* Do not speak or understand Danish",{"count":55,"type":21},[24],"Research shows that people living with cancer often struggle to manage their energy and resources in a way that allows them to take part in the everyday activities that matter most to them. Studies also show that activities that bring joy, involve physical movement, and offer social connection are especially important for coping with advanced cancer. These kinds of activities can help shift focus away from illness and problems, and instead bring meaning to the time that remains.\n\nBecause of this, people with cancer need support that both helps them function as well as possible and gives them opportunities to experience relief and well-being.\n\nThe project \"Balance, Activity and Quality of Life\" (BALanSE) focuses on developing and testing a community-based program that supports people in finding balance in their daily activities, experiencing joy, and improving their quality of life. The program is mainly group-based and includes workshops with presentations and hands-on activities.\n\nA first version of the program was tested at the research clinic at REHPA - the Danish Knowledge Centre for Rehabilitation and Palliative Care - and showed that participants experienced improved health-related quality of life. This positive outcome forms the basis for further developing the program into a municipal service, so more people can benefit from it.\n\nThe next phase of development and testing is being done in collaboration with the Center for Cancer Rehabilitation and Palliative Care in Odense Municipality. The project also includes research-based strategies to reduce social inequality in health.\n\nThe project is anchored at the Research Unit for User Perspectives and Citizen-Centered Interventions at the University of Southern Denmark.\n\nThe overall goal of the project is to further develop and test the program as a municipal service for people with cancer, supporting them in managing daily life and participating in meaningful activities that bring joy and balance-ultimately helping them experience the best possible quality of life.",[243],"Cancer",[245],"Cancer and every day llife","2026-04-22",{"date":197,"type":36},{"date":249,"type":21},"2026-06-01",{"date":251,"type":21},"2026-11-01",{"name":42,"class":43},{"id":254,"slug":255,"hasResults":12,"nctId":256,"briefTitle":257,"officialTitle":258,"acronym":4,"eligibilityCriteria":259,"healthyVolunteers":187,"sex":17,"minAge":260,"maxAge":261,"enrollmentInfo":262,"targetDuration":4,"studyType":22,"phases":264,"briefSummary":265,"conditions":266,"keywords":272,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":289,"startDateStruct":290,"completionDateStruct":291,"leadSponsor":292,"locationsCount":4},"100633792","peerscreen-trial---reducing-screen-media-use-in-peer-groups-of-young-people-100633792","NCT07531290","PeerScreen Trial - Reducing Screen Media Use in Peer-groups of Young People","Effects of Reducing Screen Media Use on Mental Health, Sleep, Physical Activity, Heart Rate Variability, and Behavioral Patterns in Peer-groups of Young People: A Study Protocol for a Cluster-randomized Controlled Trial","Inclusion Criteria:\n\n* Participants must have at least 2 hours\u002Fday of self-reported smartphone use during leisure time (data from the survey study)\n* Members of each participant's household must be willing to support the participant in adhering to the prescribed intervention (data from recruitment interview)\n* Participants must have enough discretionary leisure time for possible in-person activities on a weekly basis throughout the study period (verified at the information meeting)\n\nExclusion Criteria:\n\n* Participants with no smartphone will be excluded (data from recruitment interview)\n* Participants with no social media profiles will be excluded (data from recruitment interview)\n* Participants who currently participate in other experimental studies will be excluded (data from recruitment interview)\n* Participants who have been hospitalized or prescribed sick leave within the past 3 months due to a mental illness will be excluded (data from recruitment interview)","13 Years","24 Years",{"count":263,"type":21},240,[24],"The purpose of the PeerScreen trial is to investigate whether reducing screen media use affects mental health, social interaction, sleep, physical activity, heart rate variability, and behavioral patterns in young people aged 13 to 24 years. The primary question the trial aims to answer is:\n\nDoes reducing screen media use over a 4-week period improve mental health among young people?\n\nResearchers will compare a screen media reduction intervention with a control condition in which participants continue their usual screen media use to determine whether reducing screen media use leads to improvements in mental health.\n\nParticipants will:\n\n* be allocated to either a 4-week screen media reduction intervention or a control condition\n* complete a study protocol including questionnaire-based assessments, daily self-reports, and objective monitoring of screen media use, sleep, physical activity, heart rate variability, social interactions, and geolocation",[267,268,269,270,271],"Mental Health","Social Interaction","Sleep","Physical Activity","Stress",[273,274,275,276,277,278,279,280,281,282,283,284,285,286,287],"digital media use","screen time","adolescent","youth","young adult","mental health","social interaction","behavioral pattern","screen media use","heart rate variability","sleep","physical activity","well being","peer group","interpersonal synchrony","2026-04-08",{"date":38,"type":36},{"date":38,"type":21},{"date":40,"type":21},{"name":42,"class":43},{"id":294,"slug":295,"hasResults":12,"nctId":296,"briefTitle":297,"officialTitle":298,"acronym":299,"eligibilityCriteria":300,"healthyVolunteers":12,"sex":17,"minAge":301,"maxAge":4,"enrollmentInfo":302,"targetDuration":4,"studyType":22,"phases":304,"briefSummary":305,"conditions":306,"keywords":312,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":288,"lastUpdatePostDateStruct":318,"startDateStruct":320,"completionDateStruct":322,"leadSponsor":324,"locationsCount":44},"100550793","prioritising-patient-medication-review-hospitals-reaching-out-100550793","NCT06451692","Prioritising Patient Medication Review: Hospitals Reaching Out","Prioritising Patient Medication Review: Hospitals Reaching Out (PriPMed)","PriPMed","Inclusion Criteria:\n\n* all hospitalized patients who are prescribed at least seven medications specified in the Electronic Patient Journal (EPJ) at admission\n\nExclusion Criteria:\n\n* terminal patients or patients with a short life expectancy, patients residing in another region, patients who are discharged on the day of inclusion, and finally patients who do not speak Danish.","65 Years",{"count":303,"type":21},800,[24],"To examine the effect of a cross-sectoral medication review intervention to admitted multi-morbid, polypharmacy patients aged 65+ at SHS in two settings; an acute admission unit (typical admission time \\\u003C 48 hours) and a medical outpatient setting (patients routinely visits for follow-up, diagnosis or treatment, but do require a bed or overnight care).",[307,308,309,310,311],"Medication Review","Polypharmacy","General Practitioners","Interdisciplinary Communication","Clinical Pharmacy",[313,314,315,316,317,308],"Multi-morbidity","Medication review","Dementia","Clinical Fragility scale","Hospital to home transition",{"date":319,"type":36},"2026-04-13",{"date":321,"type":36},"2024-06-17",{"date":323,"type":21},"2027-06-01",{"name":42,"class":43},{"id":326,"slug":327,"hasResults":12,"nctId":328,"briefTitle":329,"officialTitle":330,"acronym":4,"eligibilityCriteria":331,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":332,"targetDuration":4,"studyType":22,"phases":334,"briefSummary":335,"conditions":336,"keywords":340,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":344,"lastUpdatePostDateStruct":345,"startDateStruct":347,"completionDateStruct":349,"leadSponsor":351,"locationsCount":352},"100571058","intravenous-versus-oral-treatment-of-the-main-acute-infections-100571058","NCT06715306","Intravenous Versus Oral Treatment of the Main Acute Infections","Intravenous Versus Oral Treatment of the Main Acute Infections in Emergency Departments","Inclusion Criteria:\n\n* Suspected respiratory tract infection, urinary tract infection, or cellulitis by the attending physician\n* Planned or initiated intravenous antibiotic treatment\n\nExclusion Criteria:\n\n* if received more than two doses of intravenous antibiotics;\n* systolic blood pressure \\\u003C90 mmHg;\n* nausea and\u002For vomiting in more than one short-term instance during the last 2 days;\n* suspected significantly reduced gastrointestinal absorption;\n* confirmed plasma-lactate \\> 2;\n* pregnant or nursing;\n* unable to give informed consent;\n* severe immunodeficiency;\n* urgent vital treatment needed.",{"count":333,"type":21},4000,[24],"Patients admitted to the hospital with acute infections are often treated with intravenous (IV) antibiotics. Around 70% of these infections fall into three categories: respiratory tract infections, urinary tract infections, and cellulitis. A Danish study found that 76% of patients admitted with suspected community-acquired pneumonia and treated with antibiotics received them intravenously. Based on an extrapolated estimate from an unpublished local survey, approximately 50,000 patients in Denmark are admitted each year for infections and treated with IV antibiotics. The average hospital stay for these patients is 5.9 days, resulting in a total of 295,000 hospital days annually, accounting for about 7% of total hospital admissions in Denmark. This represents an annual cost of 2.3 billion DKK. While some patients need hospitalization due to their overall health or other serious conditions, others remain hospitalized primarily to receive IV antibiotics.\n\nExpanding the use of oral antibiotics in emergency departments should be pursued only if it can demonstrate comparable efficacy and safety to IV administration. Therefore this study will investigate the efficiency of primarily oral antibiotics in acutely admitted patients with proven or suspected infections. Additionally, the investigators will evaluate the safety of oral regimen for these patients.",[337,338,339],"Respiratory Tract Infections","Urinary Tract Infections","Cellulitis",[341,342,343],"Oral antibiotic therapy","intravenous antibiotic therapy","intravenous-to-oral-switch","2026-03-03",{"date":346,"type":36},"2026-03-05",{"date":348,"type":36},"2025-01-15",{"date":350,"type":21},"2028-01-06",{"name":42,"class":43},7,{"id":354,"slug":355,"hasResults":12,"nctId":356,"briefTitle":357,"officialTitle":357,"acronym":358,"eligibilityCriteria":359,"healthyVolunteers":12,"sex":17,"minAge":260,"maxAge":360,"enrollmentInfo":361,"targetDuration":4,"studyType":22,"phases":363,"briefSummary":364,"conditions":365,"keywords":367,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":369,"lastUpdatePostDateStruct":370,"startDateStruct":372,"completionDateStruct":373,"leadSponsor":375,"locationsCount":44},"100617122","the-echo-study-compassion-focused-therapy-for-young-voice-hearers-and-their-caregivers-100617122","NCT07314515","The ECHO Study: Compassion-focused Therapy for Young Voice Hearers and Their Caregivers","ECHO","Inclusion Criteria:\n\n* The participants should have been referred to a child and adolescent psychiatric hospital in Denmark .\n* The participants have heard voices within the last 2 weeks.\n* The participant can hear the content of the voices. The content takes the form of spoken works.\n* A caregiver who can participate in 5 sessions\n\nExclusion Criteria:\n\n* Participants has an estimated IQ under 70\n* Participants who don't speak and understand Danish,\n* Current drug misuse \u002F abuse (during sessions)\n* Brain injury or neurological disorder e.g. severe epilepsy\n* Impaired vision or hearing to a degree that makes participation in therapy under normal conditions impossible.","21 Years",{"count":362,"type":21},80,[24],"In this project, a 10-session treatment program was developed aimed at young people who experience voice hearing. The treatment has potential to easily be implemented in everyday clinical practice in Child and Adolescent Psychiatry, and eventually in Educational Psychological Counselling (PPR) and the newly established STIME services (low-threshold municipal treatment offers for children and young people).\n\nAs part of the treatment, the young person's caregivers are involved. This means a high degree of involvement from adults who know the young person well and are part of their daily life.\n\nIn addition to traditional Compassion-focuced therapy (CFT), the treatment is expanded with an intervention where an audio file is recorded with content corresponding to the adolescent's voice hearing. The parents are invited to listen to the audio file while participating in a therapy session. This will help improve the caregivers understanding of the young person's experiences and challenges.",[366],"Hallucinations, Auditory",[368],"voice hearing","2026-02-23",{"date":371,"type":36},"2026-02-24",{"date":249,"type":21},{"date":374,"type":21},"2029-01",{"name":42,"class":43},{"id":377,"slug":378,"hasResults":12,"nctId":379,"briefTitle":380,"officialTitle":381,"acronym":4,"eligibilityCriteria":382,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":18,"enrollmentInfo":383,"targetDuration":4,"studyType":22,"phases":385,"briefSummary":386,"conditions":387,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":199,"lastUpdatePostDateStruct":391,"startDateStruct":392,"completionDateStruct":394,"leadSponsor":396,"locationsCount":203},"100625749","should-anaesthesiologists-be-taught-to-perform-ultrasound---assisted-neuraxial-access-in-spinal-anaesthesia-100625749","NCT07426679","Should Anaesthesiologists Be Taught to Perform Ultrasound-- Assisted Neuraxial Access in Spinal Anaesthesia?","Should Anaesthesiologists Be Taught to Perform Ultrasound-- Assisted Neuraxial Access in Spinal Anaesthesia?-Protocol of a Randomised Controlled Study","Inclusion Criteria:\n\n* Physicians will be included using the following inclusion criteria:\n\n  1. Physicians working in anaesthesia\n  2. Opportunity to use the spinal block technique within 2 weeks of the training session.\n\nEligible patients will be those scheduled for elective lower limb surgery requiring spinal anaesthesia.\n\nExclusion Criteria:\n\n* Exclusion criteria: Patients under 18 years of age.",{"count":384,"type":21},40,[24],"Neuraxial blockade is commonly performed using a manual palpation technique, but the procedure can be challenging, particularly in patients with high body mass index, pregnancy, or spinal deformities. Preprocedural ultrasound may improve identification of the optimal injection site, yet its use in clinical practice remains limited, partly due to a lack of structured training.\n\nThis multicentre randomised controlled trial investigates whether anaesthesiologists performing ultrasound-assisted spinal anaesthesia achieve better clinical outcomes and higher patient satisfaction compared with the traditional manual palpation technique. Both novice anaesthesia residents and more experienced anaesthesiologists are included.\n\nParticipants receive structured simulation-based training using either ultrasound-assisted or manual palpation techniques, following a mastery learning approach with predefined performance standards. After certification, participants perform spinal anaesthesia during elective lower limb surgery, with clinical performance assessed by senior anaesthesiologists.\n\nThe primary outcome is first-attempt success of spinal block. Secondary outcomes include number of attempts, needle redirections, time spent, need for assistance, and overall block success. Patient satisfaction and complications are assessed as tertiary outcomes.\n\nThis study aims to provide evidence on the clinical effects of structured training in ultrasound-assisted neuraxial access and to explore the role of prior clinical experience.",[388,389,390],"Ultrasound","Spinal Anaesthesia","Simulation Based Medical Education",{"date":369,"type":36},{"date":393,"type":36},"2026-02-01",{"date":395,"type":21},"2026-12-31",{"name":42,"class":43},{"id":398,"slug":399,"hasResults":12,"nctId":400,"briefTitle":401,"officialTitle":401,"acronym":402,"eligibilityCriteria":403,"healthyVolunteers":12,"sex":404,"minAge":18,"maxAge":4,"enrollmentInfo":405,"targetDuration":4,"studyType":22,"phases":407,"briefSummary":408,"conditions":409,"keywords":411,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":420,"leadSponsor":422,"locationsCount":44},"100622488","evaluating-the-effectiveness-of-an-internet-based-therapy-icare-to-treat-symptoms-of-postpartum-depression-100622488","NCT07384273","Evaluating the Effectiveness of an Internet-based Therapy (iCARE) to Treat Symptoms of Postpartum Depression","iCARE","Inclusion Criteria:\n\n* Given birth within 6 months\n* Edinburgh Postnatal Depression Scale (EPDS) score above 7\n* ≥age 18\n* Access to the internet\n\nExclusion Criteria:\n\n* Do not understand Danish language,\n* Substance abuse or dependence\n* Alcohol abuse, defined by a weekly consumption of alcohol exceeding 10 units\n* A diagnosis of schizophrenia, other psychotic disorders or in immediate need of psychiatric treatment.","FEMALE",{"count":406,"type":21},352,[24],"Postpartum depression (PPD) is a common and serious condition affecting 9.5% of women in high-income countries, and around 8% in Denmark. It shares core features with major depression, including low mood, loss of interest, and impaired functioning. Untreated PPD can persist for months, negatively impacting maternal well-being, child development, and family dynamics. In Denmark, systematic screening using the Edinburgh Postnatal Depression Scale (EPDS) is standard practice, but access to PPD treatment varies widely across municipalities.\n\nCognitive behavioral therapy (CBT) is the most effective psychological intervention for perinatal depression, yet limited availability and long wait times create barriers to access to care. Internet-based CBT (iCBT) offers a scalable, cost-effective alternative that can be delivered flexibly at home. Evidence supports the efficacy of self-guided iCBT for depression, though challenges such as high dropout rates have been reported. International trials in Norway, Portugal, Iran, South Korea, and the US have shown promising results for iCBT in perinatal populations. Some recent iCBT based interventions have also incorporated elements of Acceptance and Commitment Therapy (ACT) - which emphasizes psychological flexibility via mindfulness-based acceptance and values-driven action-and have demonstrated efficacy in reducing postpartum depression symptoms. These kinds of interventions (either iCBT or iCBT + ACT) have not yet been tested and evaluated in Denmark.\n\nThis clinical trial aims to evaluate whether adding an iCBT intervention with elements from ACT (iCARE) to treatment as usual (TAU) is more effective than TAU alone in reducing depressive symptoms in mothers with symptoms of PPD.\n\nMoreover, a qualitative process evaluation of the iCARE will explore implementation, acceptability, and mechanisms of impact. Its primary aim is to understand how participants experience the iCARE intervention and TAU, focusing on implementation fidelity, acceptability, and contextual influences. The secondary aim is to explore perceived mechanisms of change (e.g., cognitive, emotional, behavioral) and barriers\u002Ffacilitators to engagement.",[410],"Postpartum Depression (PPD)",[412,413,414,415,224],"Postpartum depression","Cognitive behavioural therapy","Internet-based therapy","Acceptance and commitment therapy","2026-02-03",{"date":418,"type":36},"2026-02-05",{"date":393,"type":36},{"date":421,"type":21},"2028-08-01",{"name":42,"class":43},{"id":424,"slug":425,"hasResults":12,"nctId":426,"briefTitle":427,"officialTitle":428,"acronym":4,"eligibilityCriteria":429,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":430,"targetDuration":4,"studyType":22,"phases":432,"briefSummary":433,"conditions":434,"keywords":436,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":442,"lastUpdatePostDateStruct":443,"startDateStruct":445,"completionDateStruct":446,"leadSponsor":448,"locationsCount":4},"100621652","online-interventions-to-prevent-alcohol-use-disorders-100621652","NCT07373405","Online Interventions to Prevent Alcohol Use Disorders","Internet-based Interventions to Prevent the Development and Progression of Alcohol Use Disorders With and Without Internalizing and Externalizing Symptoms in Non-treatment Seekers: Protocol for a Nationwide Randomized Controlled Trial","Inclusion Criteria:\n\n* Signing written informed consent\n* Being aged ≥ 18 years\n* Being a Danish resident and fluent in Danish\n* Having at least weekly access to a computer or mobile phone with internet\n* Having at least hazardous alcohol use, corresponding to an AUDIT cut-off score of ≥ 8\u002F6 for men\u002Fwomen (no upper limit on the AUDIT score, as the alternative is no preventive intervention)\n\nExclusion Criteria:\n\n* Receiving other psychological treatment\n* Being suicidal or having severe comorbid psychiatric disorders (e.g., psychotic disorders).",{"count":431,"type":21},3519,[24],"Background: Internet-based interventions can improve access to non-treatment-seeking populations, preventing the onset or progression of alcohol use disorder (AUD). Stepped-care guidelines for face-to-face AUD interventions recommend internet-based Brief Intervention (iBI) or unguided Cognitive Behavioural Therapy (iCBT) for no or mild AUD, and guided iCBT for moderate to severe AUD. However, no large-scale superiority trial has compared the effectiveness of these interventions among non-treatment-seeking individuals across the full spectrum of problematic alcohol use.\n\nAims: 1) Compare the effectiveness of iBI, unguided, and guided iCBT in reducing alcohol consumption in non-treatment-seeking individuals with sub-threshold or full AUD; 2) develop models via machine learning for personalized AUD prevention and progression management.\n\nMethods: A nationwide sample of 3519 individuals will be stratified by sub-threshold\u002Fmild AUD and moderate\u002Fsevere AUD and randomized to: 1) online assessment (OA)+ iBI; 2) OA+ unguided iCBT; or 3) OA+ guided iCBT. The iCBT sessions will address problematic alcohol use and co-occuring externalizing and internalizing psychiatric symptoms. Data will be collected from OA, interventions, and Danish registries at baseline and 3-, 6-, 12-, and 24-month follow-ups, with registry follow-up over 10 years.\n\nPerspectives: Findings will compare stepped-care and machine learning-driven personalized approaches to inform guidelines for non-treatment-seeking populations. Internet-based assessment and interventions support continuous data collection, enabling ongoing improvements and personalized prevention. This large-scale dissemination targeting non-treatment-seeking populations across the full spectrum of problematic alcohol use will pave the way for future initiatives and may refine prevention strategies if the stepped-care model proves insufficient for this group.\n\nKey words: Alcohol Use Disorder, Internet-Based Interventions, Machine Learning, Non-treatment Seekers, Stepped-Care",[435],"Alcohol Use Disorder (AUD)",[437,438,439,440,441],"Alcohol Use Disorder","Internet-Based Interventions","Machine Learning","Non-treatment Seekers","Stepped-Care","2026-01-19",{"date":444,"type":36},"2026-01-28",{"date":393,"type":21},{"date":447,"type":21},"2038-12",{"name":42,"class":43},{"id":450,"slug":451,"hasResults":12,"nctId":452,"briefTitle":453,"officialTitle":453,"acronym":4,"eligibilityCriteria":454,"healthyVolunteers":187,"sex":17,"minAge":455,"maxAge":456,"enrollmentInfo":457,"targetDuration":4,"studyType":22,"phases":459,"briefSummary":460,"conditions":461,"keywords":464,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":480,"lastUpdatePostDateStruct":481,"startDateStruct":483,"completionDateStruct":485,"leadSponsor":487,"locationsCount":44},"100570296","the-bloom-study---a-safe-and-healthy-start-in-life-100570296","NCT06705400","The Bloom Study - a Safe and Healthy Start in Life","Inclusion Criteria:\n\nAll children born from first-time mothers being in gestation week 20 between November 1st 2024 and October 31st 2025.\n\nExclusion Criteria:\n\nNot being able to receive digital post.","0 Months","6 Months",{"count":458,"type":21},3500,[24],"The aim of the Bloom Study is to promote healthy weight development among infants through a home-based health promoting intervention implemented in the Danish setting of community health nurses. The intervention begins during pregnancy and runs until the child reaches the age of 30 months.\n\nThe Bloom Intervention was developed over a six-year period from 2017 to 2023 according to the Intervention Mapping approach and based on a co-creation process.\n\nThe Bloom Intervention is evaluated in a cluster-randomized trial involving 22 Danish municipalities (11 intervention and 11 control). All children born from first-time mothers over a period of 12 months are invited to participate.",[462,463],"Overweight, Childhood","Obesity in Children",[465,466,467,468,469,470,471,472,473,474,475,476,477,478,479,269],"The Bloom Study","Intervention","Infants","Weight status","Community health nurses","Home-based","Randomized controlled trial","Children","Multi-component","Health promotion and prevention","Overweight","Obesity","Food habits and meals","Motor skills and movement","Screen use","2025-12-15",{"date":482,"type":36},"2025-12-22",{"date":484,"type":36},"2024-11-01",{"date":486,"type":21},"2029-03-31",{"name":42,"class":43},{"id":489,"slug":490,"hasResults":12,"nctId":491,"briefTitle":492,"officialTitle":493,"acronym":4,"eligibilityCriteria":494,"healthyVolunteers":187,"sex":404,"minAge":18,"maxAge":4,"enrollmentInfo":495,"targetDuration":4,"studyType":22,"phases":497,"briefSummary":498,"conditions":499,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":505,"lastUpdatePostDateStruct":506,"startDateStruct":508,"completionDateStruct":510,"leadSponsor":511,"locationsCount":44},"100600961","pelvic-floor-muscle-training-during-pregnancy-100600961","NCT07104292","Pelvic Floor Muscle Training During Pregnancy","PFMT During Pregnancy - Its Implementation and Effects on Pelvic Floor Disorders, Sexual Function and Obstetric Outcomes: a Hybrid Type 1 Design Randomised Controlled Trial","Inclusion Criteria:\n\n* Woman in the 1st trimester of pregnancy (up to 12+6 weeks of gestation)\n* Para 0 (no previous birth or pregnancy \\> 16 weeks of gestation)\n* Understands, writes, and reads fluently in Danish or English\n* Has a smart phone or computer\u002Ftablet to reach the training program\n\nExclusion Criteria:\n\n* Severe psychiatric illness (e.g. schizophrenia, bipolar disorder, severe depression or anxiety)\n* Active substance abuse\n* Acute social crises (e.g. homelessness, ongoing domestic violence, severe financial instability, lack of social support)\n* Women with limited capacity to provide informed consent (due to cognitive impairment or language barriers)\n* Previous pregnancy of \\> 16 weeks of gestation",{"count":496,"type":21},734,[24],"The project seeks to investigate effectiveness of PFMT during pregnancy.",[500,501,502,503,504],"Pelvic Floor","Urinary Incontinence","Anal Incontinence","Pelvic Organ Prolapse","Sexual Dysfunction","2025-11-21",{"date":507,"type":36},"2025-11-28",{"date":509,"type":36},"2025-10-27",{"date":421,"type":21},{"name":42,"class":43},{"id":513,"slug":514,"hasResults":12,"nctId":515,"briefTitle":516,"officialTitle":516,"acronym":4,"eligibilityCriteria":517,"healthyVolunteers":12,"sex":404,"minAge":18,"maxAge":4,"enrollmentInfo":518,"targetDuration":4,"studyType":520,"phases":4,"briefSummary":521,"conditions":522,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":525,"startDateStruct":527,"completionDateStruct":529,"leadSponsor":531,"locationsCount":179},"100549192","clinical-biomarker-of-paclitaxel-induced-peripheral-neuropathy-100549192","NCT06430814","Clinical Biomarker of Paclitaxel-induced Peripheral Neuropathy","Inclusion Criteria:\n\n* Age \\> 18 years\n* Willing to give informed consent\n* Scheduled to receive neo-adjuvant or adjuvant paclitaxel treatment\n* Able to speak and understand Danish\n* Diagnosed with breast cancer\n* Paclitaxel naïve patients\n\nExclusion Criteria:\n\n* Neurodegenerative diseases (e.g., neuropathy from another cause, previous apoplexy, disc herniation\n* Type 1 or 2 diabetes\n* Pregnant\n* Breastfeeding\n* Relapse of cancer diagnosis\n* Diagnosed with human immunodeficiency virus (HIV)\n* Participation in other clinical trials where the dose of paclitaxel is changed, or the aim is to prevent neuropathic pain or decrease NFL level (except if the intervention is to use cooling gloves).\n* Previous treatment with neurotoxic chemotherapy\n* Chronic pain from another cause\n* Metastatic cancer",{"count":519,"type":21},188,"OBSERVATIONAL","Investigation of which patients treated with paclitaxel have an increased risk of developing peripheral neuropathy.",[523],"Chemotherapy-induced Peripheral Neuropathy","2025-08-25",{"date":526,"type":36},"2025-09-02",{"date":528,"type":36},"2024-10-10",{"date":530,"type":21},"2027-09",{"name":42,"class":43},{"id":533,"slug":534,"hasResults":12,"nctId":535,"briefTitle":536,"officialTitle":537,"acronym":538,"eligibilityCriteria":539,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":108,"enrollmentInfo":540,"targetDuration":4,"studyType":22,"phases":542,"briefSummary":543,"conditions":544,"keywords":546,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":524,"lastUpdatePostDateStruct":555,"startDateStruct":556,"completionDateStruct":558,"leadSponsor":560,"locationsCount":44},"100430048","digital-individualized-and-collaborative-treatment-of-t2d-in-general-practice-based-on-decision-aid-100430048","NCT04880005","Digital Individualized and Collaborative Treatment of T2D in General Practice Based on Decision Aid","Protocol for the Digital, Individualized, and Collaborative Treatment of Type 2 Diabetes in General Practice Based on Decision Aid (DICTA) - A Randomized Controlled Trial","DICTA","Inclusion Criteria:\n\n* Diabetes type 2 in up to 10 years\n\nExclusion Criteria:\n\n* Fails to complete the initial questionnaire\n* No Internet access in own home through computer or smart phone\n* Is pregnant or actively trying to get pregnant\n* Has a serious or life-threatening disease",{"count":541,"type":21},400,[24],"The purpose of this project is to improve life of patients with type 2 diabetes through an IT-supported lifestyle and treatment intervention.\n\nThe intervention is based on combining and adapting existing and effective elements into the IT system of the general practitioner. In this way we will integrate specialist supervised treatment in general practice, individual patient coaching, and improved information exchange and data mining.\n\nThe DICTA intervention consists of two integrated components: a patient-directed eHealth lifestyle coaching program delivered via the LIVA application, and a clinician-directed CDS tool embedded into the EPJ system.\n\n1. eHealth lifestyle coaching: Individuals with T2D in the intervention group will receive individualized digital coaching from a health coach through the LIVA application. PROs are shared with GPs and health staff via the EPJ, enabling tailored, data-driven lifestyle support.\n2. CDS: GPs receive real-time, individualized, algorithm-based pharmacological treatment recommendations for managing T2D, hypertension, and hypercholesterolemia, as appropriate.\n\nThis is expected to facilitate use, assure individually tailored solutions, optimize treatment effects, and strengthen patient engagement.\n\nThe study is a randomized controlled trial (RCT). It will include 400 patients with newly diagnosed type 2 diabetes. The patients will receive either treatment based on the intervention or usual care. After one year, we will assess quality of life and cardiovascular risk factors in both groups and evaluate if one group has improved management of their type 2 diabetes compared to the other.\n\nIf the intervention proves effective, implementation on a national scale is highly feasible, and the intervention could probably be adapted to other lifestyle-related chronic diseases in Denmark and in other countries.",[545],"Diabetes type2",[547,548,549,550,551,552,553,554],"diabetes type 2 management","digital behavioral coaching","lifestyle change","health behavior change","weight loss","interactive advice","participant engagement","quality of life",{"date":526,"type":36},{"date":557,"type":36},"2021-06-01",{"date":559,"type":21},"2025-12-30",{"name":42,"class":43},{"id":562,"slug":563,"hasResults":12,"nctId":564,"briefTitle":565,"officialTitle":566,"acronym":4,"eligibilityCriteria":567,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":568,"targetDuration":4,"studyType":520,"phases":4,"briefSummary":570,"conditions":571,"keywords":573,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":576,"lastUpdatePostDateStruct":577,"startDateStruct":579,"completionDateStruct":581,"leadSponsor":583,"locationsCount":44},"100500069","stress-in-working-life-100500069","NCT05791461","Stress in Working Life","Stress in Working Life - Realist Evaluation of a Stress Management Intervention for Patients Referred to an Occupational Health Clinic Due to Work-related Stress","Inclusion Criteria:\n\n* exposure to stressful conditions at work such as a large workload and\u002For stressful organisational and managerial conditions.\n* Patients must be employed, and if on sick leave there must be plans for return to work during the intervention period.\n* Patients must exhibit severe signs of work-related stress meaning that there must have been a significant work-related impact, the patient must have had physical, psychological, and behavioural stress symptoms for more than four weeks.\n\nExclusion Criteria:\n\n* patient's work-related stress is primarily caused by cooperation problems, bullying and\u002For harassment,\n* long-term sick leave \\>26 weeks up to referral\n* more severe stress load outside of work\n* severe psychiatric conditions that requires treatment\n* current abuse of alcohol and\u002For psychoactive stimulants.",{"count":569,"type":21},500,"The goal of this realist evaluation of a Danish Cognitive Behavioral Therapy (CBT)-based stress management for patients with work-related stress is to understand what works, for whom, in what circumstances.The main objectives are:\n\nTo assess the effect of the stress management intervention on sustainable return to work.\n\nTo investigate what contexts and mechanisms are associated with patients' return to work rates and level of perceived stress after having received the stress management intervention.\n\nTo understand from a patient perspective how mechanisms work in specific contexts to generate effects of the stress management intervention.\n\nThe evaluation comprises two observational studies and one interview study. The intervention cohort are patients with work-related stress who received the stress management intervention between 2012-2018.\n\nThe comparison cohort are patients who would have been eligible to receive the intervention in 2011-2012, however they did not receive any intervention because it was not offered at that time.\n\nIn study one return to work rates are compared between the intervention cohort and the comparison cohort to find out if the intervention can help patients return to work at a faster rate.\n\nStudy two will investigate if there are any explanatory variables (such as work type, civil status or level of depressive symptoms) that may explain why some patients benefit more or less from the intervention.\n\nStudy three will explore what it is about the intervention (mechanisms) the patients find are helping them to cope with stress or the opposite in specific circumstances.",[572],"Occupational Stress",[574,413,575],"Occupational stress","Realist evaluation","2025-03-31",{"date":578,"type":36},"2025-04-03",{"date":580,"type":36},"2023-02-01",{"date":582,"type":21},"2025-07",{"name":42,"class":43},{"id":585,"slug":586,"hasResults":12,"nctId":587,"briefTitle":588,"officialTitle":588,"acronym":4,"eligibilityCriteria":589,"healthyVolunteers":12,"sex":17,"minAge":590,"maxAge":108,"enrollmentInfo":591,"targetDuration":4,"studyType":22,"phases":592,"briefSummary":593,"conditions":594,"keywords":596,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":601,"lastUpdatePostDateStruct":602,"startDateStruct":604,"completionDateStruct":606,"leadSponsor":608,"locationsCount":44},"100540672","text-messaging-to-reduce-high-risk-alcohol-use-among-older-adults-100540672","NCT06319885","Text Messaging to Reduce High-risk Alcohol Use Among Older Adults","Inclusion Criteria:\n\n* consumption of \\> 10 standard drinks á 12 gram ethanol per week (i.e., high-risk alcohol use defined by the Danish Health Authority) in the past four weeks\n* desire to reduce drinking\n* age 55 to 80 years\n* mobile phone ownership and willingness to receive and respond to text messages\n* fluency in Danish.\n\nExclusion Criteria:\n\n* drinking more than 53 standard drinks per week in the last four weeks\n* past 12 month alcohol withdrawal symptoms or lifetime history of serious withdrawal symptoms (e.g., seizures)\n* score above 12 on the Short alcohol withdrawal scale; SAWS\n* possible drug dependence (i.e., use of illegal drugs or psychotropic medication taken without prescription more than once a month)\n* indication of serious psychiatric illness (lifetime diagnosis of psychosis or bipolar disorder, inpatient treatment or medication for these, recent suicidality)\n* current alcohol\u002Fdrug abuse treatment or a desire to start alcohol\u002Fdrug abuse treatment during the study\n* medical condition that requires abstinence from alcohol\n* wish to achieve abstinence (applied to secure a focus on reduction)\n* lack of understanding of study protocol or reading difficulty as evidenced by a score of less than 7 out of 10 on the consent form quiz.","55 Years",{"count":110,"type":21},[24],"High-risk drinking is very prevalent among Danes aged 55+. It poses a serious risk to health and independent living, burdening health care systems and family members. Measures to reduce high-risk alcohol use in this growing group at need are urgently needed. A recent small study from the US shows that text messaging reduces high-risk alcohol intake in older adults. The investigators will conduct a pilot study with the same intervention in Denmark, with adaptations to language and culture. The pilot study will investigate among Danish older adults whether text messaging is well-accepted by participants and feasible in terms of reducing 1) high-risk drinking and 2) commonly accompanying problems with daily functioning, social relationships, and mental and physical health. The pilot-trial will include n=60 adults aged 55-80 years who will receive alcohol-related text messages (within a secure app for data protection purposes) over 12 weeks. Assessments will include a baseline assessment and a post-assessment.",[595],"Hazardous Alcohol Use",[597,598,599,600],"older adults","digital intervention","prevention","text messaging","2025-03-27",{"date":603,"type":36},"2025-04-02",{"date":605,"type":36},"2024-04-15",{"date":607,"type":21},"2025-04-15",{"name":42,"class":43},{"id":610,"slug":611,"hasResults":12,"nctId":612,"briefTitle":613,"officialTitle":614,"acronym":615,"eligibilityCriteria":616,"healthyVolunteers":12,"sex":17,"minAge":617,"maxAge":618,"enrollmentInfo":619,"targetDuration":4,"studyType":22,"phases":621,"briefSummary":622,"conditions":623,"keywords":627,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":635,"lastUpdatePostDateStruct":636,"startDateStruct":638,"completionDateStruct":640,"leadSponsor":642,"locationsCount":44},"100577211","wellbeing-and-resilience-among-1-3-years-old-children-of-mothers-with-complex-mental-health-problems-a-pragmatic-clinical-trial-of-online-vipp-sd-vs-care-as-usual-100577211","NCT06795347","Wellbeing and Resilience Among 1-3 Years Old Children of Mothers with Complex Mental Health Problems: a Pragmatic Clinical Trial of Online VIPP-SD Vs. Care As Usual","Wellbeing and Resilience Among 1-3 Years Old Children of Mothers with Complex Mental Health Problems: a Pragmatic Clinical Trial","WellCom","Inclusion Criteria:\n\n* child age 1 year, 0 months until 3 years, 0 months\n* living with their mother in the Region of Southern Denmark\n* mother has a mental disorder (Schizophrenia ICD-10: F20-29, Bipolar disorder ICD-10: F30-31, Moderate to severe depression ICD-10: F32-33 or Emotionally unstable personality disorder F60.3) verified in the Danish National Hospital Register-Psyk\u002Fthe Danish Psychiatric Central Research Register or by a clinician at the mental health services via the patient record\n* mother has had at least one in- or outpatient contact with mental health services within 12 months before birth of the child or during the child's lifetime verified in the Danish National Hospital Register or by a clinician at the mental health services via the patient record\n\nExclusion Criteria:\n\n* current in-patient status of the mother\n* current substance or alcohol abuse of the mother\n* mother has insufficient knowledge of Danish (interpreter required)\n* repeated intrauterine exposure to euphoriants or large amounts of alcohol (≥5 units per time or ≥7units per week) of the child\n* known syndrome or autism spectrum disorder of the child\n* mother or child has sensory impairment\n* sibling participating in study\n* family participating in another closely related research trial receiving an individualized video-feedback intervention\n* participating in active court proceedings","1 Year","3 Years",{"count":620,"type":21},120,[24],"Children of parents with severe mental disorders have an increased risk of mental disorders themselves, with more than half of this population diagnosed with a mental health condition during their life time. Already during early childhood, the risk of a mental health diagnosis is elevated by a factor 2-5, compared to children of parents without severe mental disorders. This highlights the need for preventive interventions.\n\nMental health during early childhood is inextricably linked with early parent-child interaction. Sensitive parenting plays a crucial role in the socio-emotional development of the child, and severe parental mental disorders may affect the quality of parent-child interaction.\n\nTherefore, we will test the effect of an intervention promoting sensitive parenting on mental health outcomes of 1-3 years old children of parents with severe mental disorders. The intervention will be tested in a randomized clinical trial comparing the intervention \"Video-feedback Intervention to Promote Positive Parenting and Sensitive Discipline\" (VIPP-SD) delivered online to Care As Usual. Our hypothesis is, that children in the Intervention Group will display lower levels of behavioral problems and increased attachment security compared to children in the Care As Usual Group.\n\nThe study will be conducted in the department of Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark. Participants are mothers with a diagnosis of schizophrenia, bipolar disorder, emotionally unstable personality disorder or moderate to severe depression living in the Region of Southern Denmark with their 1-3 years old child, and the father\u002Fcohabitating partner. Participants will be recruited via psychiatric outpatient clinics in the region or on the basis of information from health registers.\n\nThe primary outcome of the study is child behavioral problems. Secondary child outcomes are attachment security and mental health. Parental outcomes are parental stress and quality of life. Child cognition, parental psychiatric symptoms, childhood trauma, sensitivity, parental reflective functioning and service use data are also assessed in the study. Data are collected at baseline as well as 5 and 11 months after randomization. All participants will have the opportunity to receive feedback on their child's cognitive functioning and mental health status at baseline and at the end of the study.\n\nAfter baseline assessments, participants will be randomized to either intervention or the control group.\n\nThe intervention, VIPP-SD, is delivered online apart from the first session, which is conducted as a home visit. VIPP-SD is based on attachment and social learning theory. It is manualized and consists of 12 individual sessions alternating between video-recording of mother and child in pre-defined everyday situations and review\u002Fdiscussion of the video recordings with the mother\u002Fparents. Focus of the intervention is the childs signals and needs, and how to promote healthy socio-emotional development of the child. VIPP-SD will be carried out by health care professionals trained and certified in VIPP-SD.\n\nParticipants who are randomized to the control condition, Care As Usual, will continue as they did before enrollment to the study. Care As Usual is defined as any kind of help and support related to the social-emotional development and mental wellbeing of the child in the municipality or mental health services.",[624,625,626],"Child Mental Health","Behavioral Symptoms","Child of Impaired Parents",[628,629,630,631,632,633,634],"Parental psychiatric disorder","Child mental disorders","Prevention","Socio-emotional development","Child behavioral problems","Child externalizing problems","Parental sensitivity","2025-01-25",{"date":637,"type":36},"2025-01-28",{"date":639,"type":21},"2025-02",{"date":641,"type":21},"2028-01-31",{"name":42,"class":43},{"id":644,"slug":645,"hasResults":12,"nctId":646,"briefTitle":647,"officialTitle":648,"acronym":4,"eligibilityCriteria":649,"healthyVolunteers":12,"sex":17,"minAge":18,"maxAge":650,"enrollmentInfo":651,"targetDuration":4,"studyType":22,"phases":653,"briefSummary":654,"conditions":655,"keywords":657,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":668,"locationsCount":44},"100447169","attentional-control-training-for-treating-alcohol-use-disorder-100447169","NCT05102942","Attentional Control Training for Treating Alcohol Use Disorder","A Randomized Controlled Trial of Attentional Control Training for Treating Alcohol Use Disorder","To be eligible to participate, patients must fulfill the following criteria.\n\nInclusion criteria:\n\nThey must (1) sign written informed consent, (2) be between 18 and 65 years old (because the intervention is web-based), (3) be fluent in Danish, (4) have completed detoxification (if deemed appropriate), (5) have been admitted to primary treatment within the past eight weeks.\n\nExclusion criteria:\n\nBe color-blind, have a severe psychiatric or neurological illness (e.g., a psychotic disorder, intellectual disability, dementia) or terminal physical illness.","75 Years",{"count":652,"type":21},268,[24],"Background: There is consistent evidence that community and clinical samples of individuals with an alcohol use disorder (AUD) have attentional biases toward alcohol cues. The alcohol attentional control training program (AACTP) has shown promise for retraining these biases and decreasing alcohol consumption in community samples of excessive drinkers. However, there is a lack of evidence regarding the effectiveness of ACTP in clinical AUD samples. The main aim of the present study is to investigate whether primary pharmacological and psychological, evidence-based alcohol treatment can be enhanced by the addition of a gamified AACTP smartphone application for patients with an AUD.\n\nDesign and methods: The study will be implemented as a randomized controlled trial. A total of 268 consecutively enrolled patients with AUD will be recruited from alcohol outpatient clinics in Denmark. Patients will be randomized to one of three groups upon initiation of primary alcohol treatment: Group A: a gamified AACTP smartphone application + treatment as usual (TAU); or Group B: a gamified AACTP sham-control application + TAU. Treatment outcomes will be assessed at baseline, post-treatment, and at 3- and 6-month follow-ups. Repeated measures MANOVA will be used to compare the trajectories of the groups over time on alcohol attentional bias, alcohol craving, and drinking reductions. It is hypothesized that Group A will achieve better treatment outcomes than either Group B.\n\nPerspectives: Because attentional bias for alcohol cues is proportional to the amount of alcohol consumed, and these biases are not addressed within current evidence-based treatment programs, this study is expected to provide new evidence regarding the effectiveness of the gamified AACTP in a clinical population. Furthermore, due to promising results found using AACTP in community samples of excessive drinkers, there is a high probability that the AACTP treatment in this study will also be effective, thereby allowing AACTP to be readily implemented in clinical settings. Finally, it is expected that this study will increase the effectiveness of evidence-based AUD treatment and introduce a new, low-cost gamified treatment targeting patients with an AUD. Overall, this study is likely to have an impact at the scientific, clinical, and societal levels.",[435,656],"Attentional Bias",[658,659,660],"Cognitive bias","Attentional bias","Alcohol use disorder","2024-12-19",{"date":663,"type":36},"2024-12-24",{"date":665,"type":36},"2022-10-01",{"date":667,"type":21},"2026-04-01",{"name":42,"class":43},{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":675,"eligibilityCriteria":676,"healthyVolunteers":12,"sex":17,"minAge":677,"maxAge":678,"enrollmentInfo":679,"targetDuration":4,"studyType":22,"phases":681,"briefSummary":682,"conditions":683,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":685,"lastUpdatePostDateStruct":686,"startDateStruct":688,"completionDateStruct":690,"leadSponsor":691,"locationsCount":692},"100490974","paediatric-autism-communication-therapy-pact-in-children-with-autism-spectrum-disorder-100490974","NCT05673096","Paediatric Autism Communication Therapy (PACT) in Children With Autism Spectrum Disorder","Paediatric Autism Communication Therapy (PACT) Combined With Management as Usual Compared to Management as Usual Alone in Children With Autism Spectrum Disorder - a Pragmatic, National, Randomised Clinical Trial","DAN-PACT","Inclusion Criteria:\n\n* Children aged 2 through 6 years (both inclusive)\n* A diagnosis of ASD meeting the criteria for International Classification of Diseases; Tenth Edition (ICD-10): Diagnose codes: DF84.0, DF84.1, DF84.5, DF84.8\n* An Autism Diagnostic Observation Schedule, 2nd Edition Calibrated Severity Score (ADOS-2 CSS) ≥ 4\n* The ASD diagnosis must be verified by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), Autism Spectrum Disorder Checklist\n* The ASD diagnosis must be the primary developmental disorder (comorbid conditions allowed) and conferred at a clinical conference\n* Parents must have sufficient Danish (or English) language skills to communicate with the therapist\n* Signed informed consent by parents or holders of legal guardianship\n\nExclusion Criteria:\n\n* Children having a sibling already included in the trial\n* Hearing and visual impairment in child or parent\n* Parent not available for regular sessions with the therapist, evaluated at the consent meeting","2 Years","6 Years",{"count":680,"type":21},280,[24],"Paediatric Autism Communication Therapy (PACT) is a naturalistic developmental behavioural interventions to reduce autism symptoms. The aim of this trial is to assess the beneficial and harmful effects of PACT in 2-6 year-old children with a recent diagnosis of autism spectrum disorder.",[684],"Autism Spectrum Disorder","2024-12-05",{"date":687,"type":36},"2024-12-11",{"date":689,"type":36},"2023-03-13",{"date":395,"type":21},{"name":42,"class":43},6,""]