[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Texas, El Paso\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":277},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,52,91,119,156,182,205,229,254],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":4,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":30,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":40,"lastUpdatePostDateStruct":41,"startDateStruct":44,"completionDateStruct":46,"leadSponsor":48,"locationsCount":51},"100641665","efficacy-of-tele-cpass-compared-to-in-person-cpass-therapy-for-upper-extremity-motor-recovery-100641665",false,"NCT07661849","Efficacy of Tele-CPASS Compared to In-person CPASS Therapy for Upper Extremity Motor Recovery","Efficacy of Tele-CPASS, a Telerehabilitation Intervention Using Critical Periods After Stroke Study (CPASS) Compared to In-person CPASS for Upper Extremity Motor Recovery","Inclusion Criteria:\n\n* Age 21 years or older\n* Neuroimaging-confirmed stroke within 40 days prior to enrollment\n* Persistent hemiparesis resulting in impaired upper extremity function, defined by a score of 0 to 3 on the NIH Stroke Scale motor arm item\n* Able to participate in all study-related activities, including 1-year follow-up\n* Short Blessed Memory Orientation and Concentration Scale score less than 8\n* Able to follow 2-step commands\n* Montreal Cognitive Assessment (MoCA) score greater than 25\n* No upper extremity injury or condition that limited upper extremity use prior to the stroke\n\nExclusion Criteria:\n\n* Inability to provide informed consent\n* Persistent disabling neurologic condition, such as multiple sclerosis, Parkinsonism, amyotrophic lateral sclerosis, or dementia requiring medication\n* Clinically significant fluctuations in mental status within 72 hours prior to randomization\n* Active psychosis, psychosis within the prior 2 years, active substance abuse, or prior substance abuse\n* Dense sensory loss, defined by a score of 3 or 4 on the NIH Stroke Scale sensory item\n* Ataxia out of proportion to weakness in the affected arm, defined by a score greater than 1 on the NIH Stroke Scale ataxia item\n* Not expected to survive 12 months because of other illnesses\n* Pregnancy\n* Severe aphasia\n* Receipt of botulinum toxin or expectation of receiving botulinum toxin during the study period","ALL","21 Years",{"count":19,"type":20},42,"ESTIMATED","INTERVENTIONAL",[23],"NA","This study evaluates whether a home-based telerehabilitation program (tele-CPASS) is as effective as an in-person rehabilitation program (CPASS) for improving arm and hand function after stroke. Stroke often leads to long-term difficulty using the affected arm in daily activities, and access to in-person therapy can be limited. This study aims to determine whether therapy delivered remotely can provide similar benefits to standard in-clinic care.\n\nParticipants who recently experienced a stroke will be randomly assigned to receive 20 hours of upper extremity rehabilitation therapy either in person or through a telehealth platform. Both groups will receive the same type and amount of therapy focused on practicing meaningful, patient-selected daily activities. Participants will complete assessments before treatment, immediately after treatment, and at 6 and 12 months to measure recovery of arm function, real-world arm use, and participation in daily life.\n\nThe results of this study will help determine whether telerehabilitation can improve access to effective stroke recovery interventions while maintaining clinical effectiveness comparable to in-person therapy.",[26,27,28,29],"Stroke","Hemiparesis","Upper Extremity Impairments","Stroke Rehabilitation",[31,32,33,34,35,36,37,38],"Telerehabilitation","Telehealth","Stroke rehabilitation","Upper extremity recovery","Motor recovery","Critical period plasticity","Wearable sensors","Accelerometry","RECRUITING","2026-06-16",{"date":42,"type":43},"2026-06-22","ACTUAL",{"date":45,"type":43},"2025-09-01",{"date":47,"type":20},"2029-08-31",{"name":49,"class":50},"University of Texas, El Paso","OTHER",3,{"id":53,"slug":54,"hasResults":11,"nctId":55,"briefTitle":56,"officialTitle":57,"acronym":4,"eligibilityCriteria":58,"healthyVolunteers":11,"sex":16,"minAge":59,"maxAge":4,"enrollmentInfo":60,"targetDuration":4,"studyType":21,"phases":62,"briefSummary":63,"conditions":64,"keywords":66,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":85,"completionDateStruct":87,"leadSponsor":89,"locationsCount":90},"100609952","changes-in-movement-fitness-and-quality-of-life-in-people-with-parkinsons-disease-after-different-exercise-programs-100609952","NCT07221266","Changes in Movement, Fitness, and Quality of Life in People With Parkinson's Disease After Different Exercise Programs","Changes in Motor Function, Quality of Life, Cardiorespiratory Fitness, and Physiological Markers in People With Parkinson's Disease Following Different Exercise Interventions.","Inclusion Criteria:\n\n1. Diagnosis of Parkinson's Disease\n2. Independent ambulation\n3. Hoehn and Yahr stage of 1-3\n4. 50 years of age or older\n5. Must speak English or Spanish\n\nExclusion Criteria:\n\n1. History of stroke\n2. History of heart attack\n3. Non-ambulatory\n4. Hoehn and Yahr of stage 4 or 5\n5. Osteoporosis\n6. Unmanaged Parkinson's medication","50 Years",{"count":61,"type":20},45,[23],"Parkinson's disease (PD) is a progressive neurological condition that can affect movement, balance, endurance, and overall quality of life. Exercise is widely recognized as one of the most effective non-pharmacological treatments to help people with PD maintain function and independence. However, not all exercise programs produce the same results, and more research is needed to understand which types of exercise offer the greatest physical and physiological benefits.\n\nThis study is designed to examine how different types of structured exercise programs influence motor function, cardiorespiratory fitness, and markers of overall health in individuals with Parkinson's disease. The goal is to better understand how exercise can be used to improve movement, daily activities, and general well-being, as well as how it affects the body at a physiological level.\n\nParticipants will be adults diagnosed with idiopathic Parkinson's disease who are medically stable and able to safely participate in exercise. Before beginning the study, participants will complete screening procedures to ensure safety and eligibility. Eligible participants will then be assigned to one of several supervised exercise interventions conducted over a defined period. Each exercise program is designed to improve movement and function but differs in structure or training emphasis (for example, aerobic, functional, or task-specific activity).\n\nExercise sessions will take place under the supervision of licensed physical therapist. Each session will include warm-up, exercise, and cool-down components. Intensity will be monitored using heart rate and perceived exertion to ensure safety and appropriate challenge. Participants will attend sessions multiple times per week for 8 weeks.\n\nResearchers will collect information about movement abilities, balance, walking, endurance, and daily function using standardized physical therapy assessments such as gait tests, balance measures, and questionnaires related to quality of life at baseline, after 8-weeks of intervention and once more after a 4-week follow-up. In addition, blood samples will be collected to analyze physiological responses to exercise at the same 3 testing intervals. These samples will allow investigators to measure biomarkers related to cardiovascular health, nitric oxide availability, oxidative stress, and inflammation. These biological indicators can help identify how exercise affects underlying health mechanisms that may contribute to improved function in people with Parkinson's disease.\n\nAll data will be collected by trained research personnel who are experienced in working with individuals with Parkinson's disease. Participants will be monitored for safety at each session, and any adverse events will be documented and reviewed by the principal investigator and the Institutional Review Board (IRB).\n\nBy comparing changes across the different exercise programs, this study aims to determine which interventions have the most meaningful impact on mobility, endurance, and quality of life, as well as which ones produce measurable physiological benefits. Results from this research may help guide physical therapists, rehabilitation professionals, and people with Parkinson's disease in choosing the most effective exercise approaches for maintaining function and promoting overall health.\n\nUltimately, this project seeks to contribute to the growing evidence that targeted, engaging, and appropriately dosed exercise can play a key role in improving the lives of people living with Parkinson's disease. The findings may also help inform future clinical practice guidelines, community exercise programs, and long-term wellness strategies for individuals with movement disorders.",[65],"Parkinson Disease (PD)",[67,68,69,70,71,72,73,74,75,76,77,78,79,80,81],"Parkinson's Disease","Exercise intervention","Physical Therapy","Guided Cycling","Non-contact boxing","Aerobic Exercise","Quality of Life","Endothelial Function","Blood Biomarkers","Homocysteine","Vitamin B-12","Inflammation","Oxidative stress","Balance Training","Motor Function","2026-05-04",{"date":84,"type":43},"2026-05-08",{"date":86,"type":43},"2026-04-21",{"date":88,"type":20},"2027-06-30",{"name":49,"class":50},2,{"id":92,"slug":93,"hasResults":11,"nctId":94,"briefTitle":95,"officialTitle":95,"acronym":4,"eligibilityCriteria":96,"healthyVolunteers":97,"sex":16,"minAge":98,"maxAge":4,"enrollmentInfo":99,"targetDuration":4,"studyType":21,"phases":101,"briefSummary":102,"conditions":103,"keywords":106,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":90},"100547730","evidence-based-intervention-to-improve-walking-engagement-in-el-paso-texas-100547730","NCT06411769","Evidence-based Intervention to Improve Walking Engagement in El Paso, Texas","Inclusion Criteria:\n\n* A school is eligible if it is located within one of the four target school districts\n* adult 18 years or older\n* full-time school-based school district employee\n* not pregnant and able to walk without physical limitations or assistive device\n* willing to wear our Fitbit tracking device or use their own tracking device for 18 months\n* own a smartphone\n* willingness to use a personal smartphone for tracking activity related to the Fitbit tracker, access online intervention content, and receive text messages.\n\nExclusion Criteria:\n\n* Works at more than one school\n* Does not work on a district school campus\n* schools that previously participated in walking challenges",true,"18 Years",{"count":100,"type":20},406,[23],"The investigators will test if the 50,000 for Life (50K4Life) is effective at improving walking engagement in school employees in 30 public schools by delivering a two-phased adaptive intervention to improve walking engagement in school workers in 30 public schools. In Phase 1, all study schools will be randomly assigned to a 50K4Life only, or 50K4Life + SMS Text Messaging group.\n\nIn Phase 2, non-responder schools will be randomly assigned to one of two 6-month adaptive treatments: a) an individual-level intervention that includes remote education modules (REM) and one-to-one monthly phone-based coaching, or, b) a school-level intervention that includes group educational sessions, school environmental modifications (floor distance markings, signage in corridors and breakrooms, promotional items), and work time\u002Fweekend group walks\u002Fhikes. The schools that 50% or more participants who achieve 50,000 steps in one week will continue with the Phase 1 condition. Intervention strategies will be coordinated by health educators and managed using the Pathverse app. Data collection will occur at baseline, 8 weeks (Phase 2 randomization decision point), 8 months (immediate post intervention), 12 months (4 months post-intervention), and 18 months (10 months post-intervention) for a total of 18 months of study participation.",[104,105],"Activity Trackers","Physical Activity",[107,108,109,110],"Walking Challenge","Moderate-to-Vigorous-Physical Activity","Evidence-based","Employer-based","2026-03-12",{"date":113,"type":43},"2026-03-16",{"date":115,"type":43},"2024-09-01",{"date":117,"type":20},"2027-06",{"name":49,"class":50},{"id":120,"slug":121,"hasResults":11,"nctId":122,"briefTitle":123,"officialTitle":124,"acronym":4,"eligibilityCriteria":125,"healthyVolunteers":97,"sex":16,"minAge":98,"maxAge":126,"enrollmentInfo":127,"targetDuration":4,"studyType":21,"phases":129,"briefSummary":130,"conditions":131,"keywords":134,"overallStatus":146,"whyStopped":4,"lastUpdateSubmitDate":147,"lastUpdatePostDateStruct":148,"startDateStruct":150,"completionDateStruct":152,"leadSponsor":154,"locationsCount":155},"100609196","acute-cryotherapy-on-musculoskeletal-function-and-biomarkers-100609196","NCT07211412","Acute Cryotherapy on Musculoskeletal Function and Biomarkers","Effects of Acute Cryotherapy on Musculoskeletal Function and Biomarkers for Inflammation, Oxidative Stress, and Muscle Damage","Inclusion Criteria:\n\n* apparently healthy\n* normotensive\n* non-smokers (all tobacco products including e-cigarettes)\n\nExclusion Criteria:\n\n* Cardiovascular diseases (including hypertension)\n* pregnancy\n* any musculoskeletal injury 6 months prior the study","30 Years",{"count":128,"type":20},60,[23],"In 2020, Dubois and Esculier proposed a paradigm shift in the acute management of musculoskeletal injuries, advocating for the transition from the traditional PRICE protocol- Protect, Rest, Ice, Compression, Elevation-to the more holistic PEACE \\& LOVE framework. This updated model emphasizes Protection, Elevation, Avoiding anti-inflammatories, Compression, and Education, followed by Load, Optimism, Vascularization, and Exercise. Notably, the PEACE \\& LOVE approach omits the use of ice, a decision that has sparked considerable debate. While the rationale centers on avoiding interference with the natural inflammatory and regenerative processes, this omission stands in contrast to a substantial body of animal research suggesting that cryotherapy can mitigate secondary tissue injury by reducing inflammation and metabolic activity. Despite its widespread clinical use, human studies have yet to provide conclusive evidence supporting or refuting the efficacy of cryotherapy in acute injury management, leaving clinicians to navigate between tradition, emerging evidence, and evolving philosophies of care. Even though it is important to consider natural inflammation for a better regenerative process, animal models have shown that the original injury can elicit oxidative stress, which will enhance cellular damage (secondary damage) and inflammation. Clinically, it is unknown if this secondary damage would increase functional impairment.\n\nTherefore, this proposal will determine if cryotherapy can decrease secondary damage, after exercise-induced muscle damage, and if this decrease is associated to lower inflammation, oxidative stress and functional impairments.",[132,133],"Exercise Induced Muscle Damage","Cryotherapy",[135,133,136,137,138,139,140,141,142,143,144,145],"Exercise induced muscle damage","Cold-pack","Ice-pack","Eccentric exercise","Creatine kinase","c-reactive protein","interlukin-6","8-isoprostane","Range of motion","Maximal Voluntary Isometric Contraction","Pain","NOT_YET_RECRUITING","2025-10-01",{"date":149,"type":43},"2025-10-08",{"date":151,"type":20},"2025-10-15",{"date":153,"type":20},"2026-05-15",{"name":49,"class":50},1,{"id":157,"slug":158,"hasResults":11,"nctId":159,"briefTitle":160,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":11,"sex":16,"minAge":98,"maxAge":4,"enrollmentInfo":163,"targetDuration":4,"studyType":21,"phases":165,"briefSummary":166,"conditions":167,"keywords":169,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":175,"lastUpdatePostDateStruct":176,"startDateStruct":178,"completionDateStruct":180,"leadSponsor":181,"locationsCount":155},"100500795","trial-of-a-culturally-informed-brief-intervention-to-reduce-alcohol-related-health-disparities-and-treatment-inequities-among-latinxs-100500795","NCT05800899","Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs","Stage II Efficacy Trial of a Culturally Informed Brief Intervention to Reduce Alcohol Related Health Disparities and Treatment Inequities Among Latinxs","Inclusion Criteria:\n\n* Admission to a level 1 -trauma center\n* Involved in a alcohol-related injury\n* Self-identify as Latinx\n* 18 or older\n* Minimum Blood Alcohol Concentration (BAC) score of .001 and\u002For at risk drinking\n\nExclusion Criteria:\n\n* Traumatic brain injury or otherwise debilitating injury as indicated by a Glasgow Coma Scale score of less than 15.\n* Cognitive impairment as indicated by a score of 24 or less on the Mini-Mental Status Exam",{"count":164,"type":20},600,[23],"This Stage II Randomized Efficacy Trial will compare the effectiveness of a theoretically informed and culturally responsive brief motivational intervention to a non-adapted brief intervention among non-treatment seeking Latinxs admitted for medical treatment of an injury who engage in at risk drinking or were drinking at the time of their injury. The culturally informed brief motivational intervention (CI-BMI) increases autonomous motivation to engage in protective drinking behavior and reduce alcohol problems while addressing barriers to help seeking and facilitating treatment utilization. This project will address the alcohol related health disparities and treatment inequities among Latinx who are more likely to experience alcohol problems yet less likely to receive treatment in order to reduce the negative public health impact of alcohol.",[168],"Alcohol Use Disorder",[170,171,172,173,174,168],"Brief Motivational Intervention","Cultural Adaptation","Mechanisms of Change","Self-Determination Theory","Harm Reduction","2025-08-18",{"date":177,"type":43},"2025-08-24",{"date":179,"type":43},"2023-06-30",{"date":88,"type":20},{"name":49,"class":50},{"id":183,"slug":184,"hasResults":11,"nctId":185,"briefTitle":186,"officialTitle":187,"acronym":4,"eligibilityCriteria":188,"healthyVolunteers":97,"sex":16,"minAge":98,"maxAge":4,"enrollmentInfo":189,"targetDuration":4,"studyType":21,"phases":190,"briefSummary":191,"conditions":192,"keywords":196,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":197,"lastUpdatePostDateStruct":198,"startDateStruct":200,"completionDateStruct":202,"leadSponsor":204,"locationsCount":155},"100358486","improving-glycemic-control-with-electrical-stimulation-100358486","NCT03947697","Improving Glycemic Control With Electrical Stimulation","Improving Glycemic Control With Electrical Stimulation in Mexican-Americans","Inclusion Criteria:\n\n* Overweight\u002FObese (BMI ≥25)\n* Sedentary Lifestyle: Physical Activity Level\\\u003C1.4\n* Less than 150min\u002Fweek of structured Exercise\n\nExclusion Criteria:\n\n* Use of anti-hypertensive, lipid-lowering or insulin sensitizing medications\n* Excessive alcohol, drug abuse, smoking\n* Pregnant Women\n* Unwilling to adhere to the study Intervention",{"count":128,"type":20},[23],"Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55\u002F15\u002F30% CHO\u002FPRO\u002FFAT) prior to collection of pre-intervention data of insulin sensitivity. Individuals will then participate in an 8-week electrical stimulation intervention (30min\u002Fday, 3x\u002Fweek) and randomized into placebo\u002Fcontrol, NMES, resistance training combined with NMES (RT +NMES), or resistance training (RT) group (n=15 per group), followed by collection of post-intervention data. The control group will receive electrical stimulation up to sensory level, the NMES group will receive stimulation up to tolerable intensity to induce visible muscle contraction, the RT+ NMES will receive stimulation up to tolerable intensity during resistance training, and the RT group will only receive exercise training. Pre-and post-intervention data includes measurements for body composition, resting metabolic rate, VO2max, insulin sensitivity, and comprehensive blood work.",[193,194,195],"Obesity","Overweight","Insulin Resistance",[193],"2025-02-18",{"date":199,"type":43},"2025-02-20",{"date":201,"type":43},"2022-08-09",{"date":203,"type":20},"2027-04-30",{"name":49,"class":50},{"id":206,"slug":207,"hasResults":11,"nctId":208,"briefTitle":209,"officialTitle":210,"acronym":4,"eligibilityCriteria":211,"healthyVolunteers":97,"sex":16,"minAge":212,"maxAge":213,"enrollmentInfo":214,"targetDuration":4,"studyType":21,"phases":215,"briefSummary":216,"conditions":217,"keywords":4,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":221,"lastUpdatePostDateStruct":222,"startDateStruct":224,"completionDateStruct":226,"leadSponsor":228,"locationsCount":155},"100524212","upper-and-lower-extremity-exercise-and-exercise-induced-hypoalgesia-in-knee-osteoarthritis-100524212","NCT06105788","Upper and Lower Extremity Exercise and Exercise-Induced Hypoalgesia in Knee Osteoarthritis","Comparing Effects of Upper Extremity Versus Lower Extremity Exercise on Exercise-Induced Hypoalgesia in People With Knee Osteoarthritis: A Pilot Cross-over Study","Participants with knee OA (Target n=40)\n\nInclusion Criteria:\n\nWe will recruit participants with knee OA, using the National Institute for Health and Care Excellence's clinical diagnostic criteria, which does not require radiographs. The clinical diagnostic criteria include:\n\n* age ≥45\n* activity-related knee pain\n* either no morning joint-related stiffness or stiffness that lasts ≤ 30 minutes.\n* knee pain at least 4 on a 0-10 pain scale\n* knee pain as a chief complaint if having multiple pain\n* understand English\n\nExclusion Criteria:\n\n* peripheral neuropathy or other sensation loss on the body sites for pain measurements (i.e., the wrist, knee, the forearm)\n* use of medical devices electrically active (e.g., pacemaker)\n* chronic use of opioids\n* pregnant women\n* serious and uncontrolled concomitant disease, including cardiovascular, nervous system, pulmonary, renal, hepatic, metabolic, hormonal, endocrine, gastrointestinal or epileptic disease\n* rheumatoid arthritis, ankylosing spondylitis, and any neurological disorders that prevent the study procedure\n* cognitive impairment\n* history of a knee replacement surgery\n* inability to perform exercise due to severe pain or other symptoms\n* any intervention procedures for knee pain in the last 3 months\n\nInclusion and exclusion criteria for pain-free controls (Target n = 20) Pain-free controls are not having a pain-related medical condition. They have to speak and understand English. Pain-free controls are excluded if they had experienced a pain episode, caused by musculoskeletal injury or otherwise in the previous 3 months.","45 Years","90 Years",{"count":128,"type":20},[23],"The objective of the study is to explore the effects of arm exercise (UE, arm ergometer) vs. leg exercise (LE, cycling ergometer) on exercise-induced hypoalgesia (EIH), central pain mechanisms and knee pain in people with knee osteoarthritis (OA). Furthermore, we will explore relations of socioeconomic status, racial discrimination, acculturative stress, and autonomic function to exercise effects on EIH, central pain mechanisms, and knee pain. This will be a pilot randomized cross-over study where all participants undergo Day 1 (baseline assessments), Day 2 (UE or LE), and Day 3 (UE or LE).",[218,219,220],"Knee Osteoarthritis","Knee Pain Chronic","Central Pain Syndrome","2024-12-10",{"date":223,"type":43},"2024-12-16",{"date":225,"type":43},"2023-11-15",{"date":227,"type":20},"2025-10-16",{"name":49,"class":50},{"id":230,"slug":231,"hasResults":11,"nctId":232,"briefTitle":233,"officialTitle":233,"acronym":4,"eligibilityCriteria":234,"healthyVolunteers":97,"sex":16,"minAge":98,"maxAge":235,"enrollmentInfo":236,"targetDuration":4,"studyType":21,"phases":238,"briefSummary":239,"conditions":240,"keywords":241,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":246,"lastUpdatePostDateStruct":247,"startDateStruct":249,"completionDateStruct":251,"leadSponsor":253,"locationsCount":155},"100571602","neuromuscular-electrical-stimulation-a-novel-treatment-for-improving-metabolism-100571602","NCT06722391","Neuromuscular Electrical Stimulation: A Novel Treatment for Improving Metabolism","Inclusion Criteria:\n\n* Overweight\u002FObese (BMI ≥25)\n* Sedentary Lifestyle: Physical Activity Level\\<1.4\n* Less than 150min\u002Fweek of structured Exercise\n\nExclusion Criteria:\n\n* Use of anti-hypertensive, lipid-lowering or insulin sensitizing medications\n* Excessive alcohol, drug abuse, smoking\n* Pregnant Women\n* Unwilling to adhere to the study Intervention","65 Years",{"count":237,"type":20},80,[23],"Once written consent is obtained, the participant will be provided with an accelerometer to be worn for 7 days to assess current physical activity levels. Subjects will be provided with a standardized diet (55\u002F15\u002F30% CHO\u002FPRO\u002FFAT) prior to collection of pre-intervention data of insulin sensitivity. Individuals will then participate in an 8-week electrical stimulation intervention (30min\u002Fday, 3x\u002Fweek) and randomized into placebo\u002Fcontrol, NMES, resistance training combined with NMES (RT +NMES), or resistance training (RT) group (n=20 per group), followed by collection of post-intervention data. The control group will receive electrical stimulation up to sensory level, the NMES group will receive stimulation up to tolerable intensity to induce visible muscle contraction, the RT+ NMES will receive stimulation up to tolerable intensity during resistance training, and the RT group will only receive exercise training. Control and NMES group will self administer stimulation at home. Pre-and post-intervention data includes measurements for body composition, resting metabolic rate, VO2max, insulin sensitivity, and comprehensive blood work.",[195],[242,243,244,193,245],"Neuromuscular Electrical Stimulation","Glucose Continuous Monitor","Blood Glucose","Resting Metabolic rate","2024-12-03",{"date":248,"type":43},"2024-12-09",{"date":250,"type":43},"2024-08-19",{"date":252,"type":20},"2031-09-01",{"name":49,"class":50},{"id":255,"slug":256,"hasResults":11,"nctId":257,"briefTitle":258,"officialTitle":259,"acronym":4,"eligibilityCriteria":260,"healthyVolunteers":11,"sex":16,"minAge":98,"maxAge":4,"enrollmentInfo":261,"targetDuration":4,"studyType":21,"phases":263,"briefSummary":264,"conditions":265,"keywords":267,"overallStatus":39,"whyStopped":4,"lastUpdateSubmitDate":269,"lastUpdatePostDateStruct":270,"startDateStruct":272,"completionDateStruct":274,"leadSponsor":276,"locationsCount":155},"100468260","optimizing-a-bio-behavioral-intervention-for-sustained-viral-suppression-100468260","NCT05377463","Optimizing a Bio-behavioral Intervention for Sustained Viral Suppression","Optimizing a Bio-behavioral Intervention to Promote Viral Suppression Among HIV+ People Who Inject Drugs on the U.S.-Mexico Border","Inclusion Criteria:\n\n* be at least 18 years of age\n* be able to provide informed consent\n* be eligible to receive free HIV care services in Mexico\n* be HIV positive\n* have injected drugs in the last 30 days\n* not be on methadone replacement therapy\n* be willing to discuss MAT uptake with a peer\n* sign a medical release form to have medical data abstracted\n* agree to submit and describe locator information\n* agree to return to follow-up visits\n* able to communicate in Spanish\n* screen positive for depression on the PHQ-2\n* have no plans of moving outside the study area in the next 12-months\n* meet one of the following:\n\n  1. not currently in possession of ART or not taking ART but prescribed ART or\n  2. sub-optimal ART adherence as at least one 4-day treatment interruption in the past 90 days or\n  3. sub-optimal retention in HIV care - never engaged or disengaged from HIV care as 2 or more missed clinic appointments in the last 9 months or\n  4. no viral load test done in the past six months or\n  5. self-reports a detectable viral load within the past 6 months\n\nExclusion Criteria:\n\n* has not injected drugs in the last 30 days or do not have a verifiable opioid use disorder\n* is not HIV positive\n* is receiving methadone\n* is unwilling to discuss methadone uptake with a peer\n* does not screen positive for depression\n* is not able to provide informed consent\n* does not speak Spanish\n* has plans to move out of the city\n* does not qualify to receive free HIV care services in Mexico\n* has an appearance of psychological disturbance or severe cognitive impairment that could limit understanding of study procedures as determined by study staff",{"count":262,"type":20},220,[23],"The study will test two behavioral intervention components to identify the combination of the two components that best supports people who inject drugs to achieve and sustain HIV viral load suppression.\n\nThe study design is a 2-to-the-2 factorial experiment. The 2 represents the level of each component: 0 (receive) or 1 (don't receive). The 2 represents the number of components being tested. The four components are: 1) receiving (or not receiving) peer support services for medication-assisted treatment (MAT) uptake and persistence and 2) behavioral activation therapy for depression (BAT). Therefore, in order to test which combination of components produce the best outcome, this factorial design randomizes people to 1 of 4 conditions. Each condition represents a possible combination of the 2 components above. All participants will receive patient navigation for care engagement.",[266],"HIV Viremia",[268],"HIV viral suppression","2024-08-28",{"date":271,"type":43},"2024-09-03",{"date":273,"type":43},"2023-05-10",{"date":275,"type":20},"2026-07-31",{"name":49,"class":50},""]