[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Thessaly\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":691},{"pageToken":4,"total":5,"offset":6,"count":7,"results":8},null,37,0,25,[9,45,71,95,120,143,167,191,213,241,277,304,345,367,392,424,451,473,495,534,562,586,612,641,669],{"id":10,"slug":11,"hasResults":12,"nctId":13,"briefTitle":14,"officialTitle":15,"acronym":4,"eligibilityCriteria":16,"healthyVolunteers":17,"sex":18,"minAge":19,"maxAge":20,"enrollmentInfo":21,"targetDuration":4,"studyType":24,"phases":25,"briefSummary":27,"conditions":28,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642054","health-benefits-of-dance-exercise-100642054",false,"NCT07615829","Health Benefits of Dance Exercise","Effects of a 6-month Dance Exercise Intervention on Physical Performance, Metabolic and Mental Health in Pre- and Post-menopausal Women","Inclusion Criteria:\n\n* Free of musculoskeletal injuries\n* Free of chronic non-communicable diseases\n* Normal menstrual cycle (for premenopausal women)\n* No recent childbirth (previous 12 months) (for premenopausal women)\n* At least 12 months since the oncet of menopause (for postmenopausal women)\n* Non smokers\n\nExclusion Criteria:\n\n* Pregnancy (for premenopausal women)\n* Contraindications to exercise training\n* Illness or other medical condition\n* Use of medication",true,"FEMALE","35 Years","70 Years",{"count":22,"type":23},40,"ESTIMATED","INTERVENTIONAL",[26],"NA","In Greece, people of different age groups, including young children to older adults, participate in dance exercise training. Although it is well-known that regular participation in dancing is associated with benefits such as entertainment, socialization and increased physical activity, the long-term effects of dancing on metabolic and mental health as well as physical performance remain largely unknown. Therefore, the aim of this study is to investigate the effects of a 6-month dancing exercise intervention on metabolic and mental health and physical performance in premenopausal and postmenopausal women.",[29,30,31],"Metabolic Health","Mental Health","Physical Performance","RECRUITING","2026-06-09",{"date":35,"type":36},"2026-06-12","ACTUAL",{"date":38,"type":23},"2026-05-30",{"date":40,"type":23},"2026-12-20",{"name":42,"class":43},"University of Thessaly","OTHER",1,{"id":46,"slug":47,"hasResults":12,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":4,"eligibilityCriteria":51,"healthyVolunteers":17,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":24,"phases":57,"briefSummary":58,"conditions":59,"keywords":61,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":66,"startDateStruct":67,"completionDateStruct":69,"leadSponsor":70,"locationsCount":44},"100619214","long-term-adaptations-of-skeletal-muscle-after-hybrid-training-100619214","NCT07341711","Long-term Adaptations of Skeletal Muscle After Hybrid Training","Long-term Adaptations of Skeletal Muscle in Overweight and Obese Individuals After Hybrid Training","Inclusion Criteria:\n\n* BMI: \\>25 kg\u002Fm2 and \\\u003C40 kg\u002Fm2\n* Untrained individuals (abstain \\>1 year from exercise training)\n* No dietary intervention over the last 6 months preceding the study\n* Low cardiorespiratory fitness level (VO2max: \\\u003C45 ml\u002Fkg\u002Fmin)\n* No use of any medication, dietary supplements\n* Low risk for cardiovascular disease\n* A weight loss \\\u003C10% over the last 6 months preceding the study\n* Free of non-communicable diseases (excluding metabolic syndrome)\n\nExclusion Criteria:\n\n* Low participation rate (\\\u003C80% completion of the exercise training sessions)\n* Unbalanced diet\n* Participation in additional exercise training regimes\n* Cosumption of anti-inflammatory of pain relief medication","ALL","30 Years","50 Years",{"count":56,"type":23},30,[26],"Obesity is a major challenge for public health and renders it imperative to reduce its prevalence. High intensity interval training (HIIT) is a form of exercise training that can efficiently induce weight loss in adults with overweight or obesity, even in the absence of dietary intake manipulation. Hybrid type training represents a form of HIIT, that incorporates both cardiorespiratory and musculoskeletal stimuli, by combining multiple types of exercise into a circuit-type, interval style workout. Recent evidence suggests that long-term participation in hybrid HIIT results in significant health-related benefits. However, the molecular mechanisms driving the chronic effects of hybrid HIIT on cardiometabolic and musculoskeletal health remains to be elucidated.",[60],"Obesity & Overweight",[62,63,64,65],"obesity","overweight","high-intensity interval training","skeletal muscle",{"date":35,"type":36},{"date":68,"type":36},"2026-01-08",{"date":40,"type":23},{"name":42,"class":43},{"id":72,"slug":73,"hasResults":12,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":17,"sex":52,"minAge":19,"maxAge":54,"enrollmentInfo":79,"targetDuration":4,"studyType":24,"phases":80,"briefSummary":81,"conditions":82,"keywords":84,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":90,"completionDateStruct":92,"leadSponsor":94,"locationsCount":44},"100616032","exercise-training-and-vitamin-d-metabolism-100616032","NCT07300332","Exercise Training and Vitamin D Metabolism","The Impact of Hybrid-type High-intensity Interval Training on Vitamin D Metabolism in Adults With Overweight\u002FObesity","Hybri-D","Inclusion Criteria:\n\n* BMI = 25-35 kg\u002Fm2\n* Absence of musculoskeletal injuries\n* Absence of chronic health-related complications\n* Non-smokers\n\nExclusion Criteria:\n\n* Consumption of Vitamin D supplements\n* Consumption of anti-inflammatory drugs, statins and\u002For steroids",{"count":56,"type":23},[26],"The prevalence of Vitamin D deficiency is significantly higher in adults with overweight\u002Fobesity compared to those with normal body mass index (BMI). The \"entrapment\" of Vitamin D in adipose tissue due to impaired lipolytic stimulation and\u002For adipose tissue dysfunction has been proposed as the driving mechanism. Exercise training has been proposed as a promising strategy to increase mobilization of Vitamin D from adipose tissue, given its well described role in stimulating lipolysis. Indeed, a recent study revealed that participation in moderate-intensity cardiovascular type exercise over winter can mitigate the decline in 25-hydroxyvitamin D \\[25(OH)D\\] in adults with overweight\u002Fobesity, independent of weight loss. The aim of this study is to investigate the impact of hybrid-type high-intensity interval training over winter on vitamin D metabolism, in adults with overweight\u002Fobesity.",[60,83],"Vitamin D",[63,62,85,86,64],"vitamin D","25-hydroxyvitamin D","2026-05-22",{"date":89,"type":36},"2026-05-26",{"date":91,"type":36},"2025-11-10",{"date":93,"type":23},"2026-07-20",{"name":42,"class":43},{"id":96,"slug":97,"hasResults":12,"nctId":98,"briefTitle":99,"officialTitle":100,"acronym":4,"eligibilityCriteria":101,"healthyVolunteers":12,"sex":52,"minAge":102,"maxAge":4,"enrollmentInfo":103,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":106,"conditions":107,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":114,"completionDateStruct":116,"leadSponsor":118,"locationsCount":119},"100563308","frailty-hip-fractures-and-inflammatory-biomarkers-100563308","NCT06614478","Frailty, Hip Fractures and Inflammatory Biomarkers","Frailty in Hip Fracture Patients Treated With Surgery; the Role of Simple Inflammatory Biomarkers. An Observational Study","Inclusion Criteria:\n\n* age \\>65 years, ASA PS I-III, non- institutionalized, able to communicate patients\n\nExclusion Criteria:\n\n* Patients with severe cognitive dysfunction, those treated conservatively, those with pathological fractures and patients who refused to participate","65 Years",{"count":104,"type":23},200,"OBSERVATIONAL","We ought to investigate if hip fracture patients suffering from frailty have higher inflammatory burden according to simple inflammatory biomarkers.",[108,109,110],"Frailty","Hip Fracture","Inflammatory Biomarkers","2026-05-03",{"date":113,"type":36},"2026-05-05",{"date":115,"type":36},"2023-04-01",{"date":117,"type":23},"2027-04-12",{"name":42,"class":43},2,{"id":121,"slug":122,"hasResults":12,"nctId":123,"briefTitle":124,"officialTitle":125,"acronym":126,"eligibilityCriteria":127,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":129,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":131,"conditions":132,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":136,"startDateStruct":138,"completionDateStruct":140,"leadSponsor":142,"locationsCount":119},"100549313","coagulation-factors-alterations-in-patients-undergoing-complex-thoraco-abdominal-aortic-aneurysm-repair-100549313","NCT06432387","Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair","Coagulation Factors Alterations in Patients Undergoing Complex Thoraco-abdominal Aortic Aneurysm Repair (CoFA-TAAA); a Prospective Observational Study","CoFA-TAAA","Inclusion Criteria:\n\n* Consecutive patients undergoing complex thoraco-abdominal aortic aneurysm repair in University Hospital of Larissa, after informed consent will be included.\n\nExclusion Criteria:\n\n* Refuse to participate\n* Prior surgery within 3 months\n* ASA PS \\> 3\n* Known medical history of thrombophilia or functional platelet dysfunction","18 Years",{"count":130,"type":23},58,"This study will evaluate the impact of complex thoraco-abdominal aortic aneurysm repair in coagulation during the immediate postoperative period in patients undergoing omplex thoraco-abdominal aortic aneurysm repair.",[133,134,135],"Thoraco-abdominal Aortic Aneurysm Repair","Coagulation Factors Alterations","Platelet Activation",{"date":137,"type":36},"2026-05-07",{"date":139,"type":36},"2024-12-31",{"date":141,"type":23},"2027-07-20",{"name":42,"class":43},{"id":144,"slug":145,"hasResults":12,"nctId":146,"briefTitle":147,"officialTitle":148,"acronym":149,"eligibilityCriteria":150,"healthyVolunteers":12,"sex":52,"minAge":102,"maxAge":4,"enrollmentInfo":151,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":153,"conditions":154,"keywords":157,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":161,"startDateStruct":162,"completionDateStruct":164,"leadSponsor":166,"locationsCount":44},"100446300","translation-and-cultural-adaptation-of-the-groningen-frailty-indicator-gfi-in-patients-with-hip-fracture-100446300","NCT05091645","Translation and Cultural Adaptation of the Groningen Frailty Indicator (GFI) in Patients With Hip Fracture","Translation and Cultural Adaptation of the Greek Version of the Groningen Frailty Indicator (GFI) in Patients With Hip Fracture; a Prospective Cohort Study","Gr-GFI","Inclusion Criteria:\n\n* adult patients over 65 years old with hip fractures undergoing surgery\n* an ASA (American Society of Anesthesiologists) PS (physical status) I to III\n* non-institutionalized\n* able to communicate orally or in writing\n* consent to participate\n\nExclusion Criteria:\n\n* refused to participate\n* pathological hip fractures\n* institutionalized\n* patients with hip fracture treated conservatively\n* patients with severe cognitive dysfunction\n* patients with insufficient knowledge of the Greek language",{"count":152,"type":23},89,"This study attempts to the translation and the cultural adaptation of the Groningen Frailty Indicator (GFI) questionnaire in the Greek population in patients suffering from hip fracture.",[155,156],"Frailty Syndrome","Hip Fractures",[155,158,159,160],"Hip fractures","Cultural adaptation","Translation",{"date":137,"type":36},{"date":163,"type":36},"2022-02-25",{"date":165,"type":23},"2026-11-15",{"name":42,"class":43},{"id":168,"slug":169,"hasResults":12,"nctId":170,"briefTitle":171,"officialTitle":172,"acronym":4,"eligibilityCriteria":173,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":102,"enrollmentInfo":174,"targetDuration":4,"studyType":24,"phases":176,"briefSummary":177,"conditions":178,"keywords":180,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":184,"lastUpdatePostDateStruct":185,"startDateStruct":186,"completionDateStruct":188,"leadSponsor":190,"locationsCount":44},"100593054","effectiveness-of-communication-focused-pain-neuroscience-education-in-chronic-musculoskeletal-pain-100593054","NCT07001449","Effectiveness of Communication-Focused Pain Neuroscience Education in Chronic Musculoskeletal Pain","Effectiveness of the 'Algo(S)Therapy' Pain Neuroscience Education Program Emphasizing Physiotherapists' Communication Skills in Patients With Chronic Musculoskeletal Pain: A Randomized Controlled Trial","Inclusion Criteria:\n\n* Adults aged 18 to 65 years\n* Diagnosis of chronic musculoskeletal pain in the lumbar spine, cervical spine, shoulder, or knee\n* Pain duration longer than 3 months\n* Pain intensity ≥3\u002F10 on the Numeric Pain Rating Scale (NPRS)\n* Pain present most days of the week\n* Able to understand and speak the Greek language\n\nExclusion Criteria:\n\n* Acute pain in any body region\n* Neurological disorders or myopathies\n* Chronic pain of non-musculoskeletal origin\n* Active cancer diagnosis\n* History of trauma, fractures, or surgery in the past year\n* Pregnancy\n* Diagnosis of fibromyalgia\n* Cognitive impairments affecting communication or completion of questionnaires\n* Current use of corticosteroid medication\n* Participation in other treatment programs or alternative therapies during the study period\n* Concurrent enrollment in another clinical trial",{"count":175,"type":23},90,[26],"This randomized controlled trial aims to evaluate the effectiveness of the \"Algo(S)Therapy\" Pain Neuroscience Education (PNE) program in patients with chronic musculoskeletal pain. The study will assess whether the integration of communication skills training for physiotherapists enhances the outcomes of PNE. Participants will be randomly assigned to one of three groups: (1) PNE with communication-focused delivery, (2) PNE without communication emphasis, or (3) standard- usual physiotherapy care. The primary objective is to determine whether PNE combined with enhanced communication skills leads to greater improvements in pain, function, and psychosocial outcomes compared to the other interventions.",[179],"Chronic Musculoskeletal Pain",[181,182,183],"Pain neuroscience education","Communication skills","Chronic musculoskeletal pain","2026-04-30",{"date":137,"type":36},{"date":187,"type":36},"2025-06-17",{"date":189,"type":23},"2026-08-30",{"name":42,"class":43},{"id":192,"slug":193,"hasResults":12,"nctId":194,"briefTitle":195,"officialTitle":196,"acronym":4,"eligibilityCriteria":197,"healthyVolunteers":12,"sex":52,"minAge":198,"maxAge":199,"enrollmentInfo":200,"targetDuration":4,"studyType":24,"phases":201,"briefSummary":202,"conditions":203,"keywords":4,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":206,"lastUpdatePostDateStruct":207,"startDateStruct":208,"completionDateStruct":210,"leadSponsor":212,"locationsCount":4},"100631090","the-effectiveness-of-neurodevelopmental-treatment-bobath-and-functional-physiotherapy-in-children-with-cerebral-palsy-100631090","NCT07496151","The Effectiveness of Neurodevelopmental Treatment (Bobath) and Functional Physiotherapy in Children With Cerebral Palsy.","The Effectiveness of Neurodevelopmental Treatment (Bobath) and Functional Physiotherapy on Upper Arm Strength and Trunk Control in Children With Cerebral Palsy.","Inclusion Criteria:\n\n* Age 4-12 years\n* Diagnosis of Cerebral Palsy\n* Ability to understand simple commands (cooperative child)\n* Classification in GMFCS (Levels I-IV)\n* Physical therapy interventions in Pediatric Physiotherapy Laboratories throughout Greece\n* Signed parental consent within one week of notification\n\nExclusion Criteria:\n\n* Botulinum toxin (Botox) injection within the last 3 months\n* Selective dorsal rhizotomy within the last 1 year\n* Uncontrolled epilepsy\n* Co-existing pathologies affecting the trunk and functionality\n* Age outside the range of 4-12 years","4 Years","12 Years",{"count":22,"type":23},[26],"Cerebral palsy is one of the most common causes of physical disability in childhood and is often associated with impaired trunk control, reduced upper limb strength, and limitations in functional mobility and daily activities. Trunk control is essential for postural stability and directly influences upper limb function and the ability to perform goal-directed tasks.\n\nNeurodevelopmental Treatment (NDT\u002FBobath) and functional physiotherapy are widely used approaches in pediatric neurorehabilitation. NDT\u002FBobath focuses on facilitating postural control and promoting efficient movement patterns, while functional physiotherapy emphasizes task-specific training and the improvement of motor performance through meaningful activities. However, evidence comparing the effectiveness of these approaches on trunk control and upper arm strength remains limited.\n\nThis study aims to investigate and compare the effectiveness of Neurodevelopmental Treatment (NDT\u002FBobath) and functional physiotherapy on upper arm strength and trunk control in children with cerebral palsy. Participants will be allocated to different intervention groups, with each group receiving one of the two therapeutic approaches.\n\nAdditionally, wearable Inertial Measurement Units (IMUs) will be used to provide objective and quantitative assessment of trunk movement under both static (sitting) and dynamic (functional movement) conditions.\n\nWe hypothesize that both intervention groups will demonstrate improvements in trunk control and upper arm strength, with potential differences in the magnitude of improvement between the two approaches. Furthermore, IMU-based measurements are expected to detect subtle changes in movement quality that may not be captured by traditional clinical assessment tools.\n\nThe findings of this study may contribute to a better understanding of the comparative effectiveness of commonly used therapeutic approaches and support evidence-based decision-making in pediatric rehabilitation.",[204],"Cerebral Palsy (CP)","NOT_YET_RECRUITING","2026-04-28",{"date":113,"type":36},{"date":209,"type":23},"2026-04-15",{"date":211,"type":23},"2026-12-30",{"name":42,"class":43},{"id":214,"slug":215,"hasResults":12,"nctId":216,"briefTitle":217,"officialTitle":218,"acronym":219,"eligibilityCriteria":220,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":221,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":222,"conditions":223,"keywords":228,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":235,"startDateStruct":236,"completionDateStruct":238,"leadSponsor":240,"locationsCount":44},"100634195","oxidative-stress-in-autoimmune-rheumatic-diseases-100634195","NCT07536529","Oxidative Stress in Autoimmune Rheumatic Diseases","Investigation of the Role of Redox Status of Patients With Autoimmune Rheumatic Diseases on Disease Progression: An Epidemiological Study","REDOX-ARD","Inclusion Criteria:\n\n* Adult patients (\\>18 years old), with a primary diagnosis of rheumatoid arthritis using the criteria of American College of Rheumatology (ACR)\n* Adult patients (\\>18 years old), with a primary diagnosis of psoriatic arthritis using the ClASsification criteria for Psoriatic Arthritis (CASPAR)\n* Adult patients (\\>18 years old), with a primary diagnosis of alkylosing spondyloarthritis using the criteria of Assessment of SpondyloArthritis international Society (ASAS) group\n* Adult patients (\\>18 years old) irrespective of gender\n* Adult patients (\\>18 years old) irrespective of ethnicity\n* Adult patients (\\>18 years old) irrespective of comorbidities\n* Adult patients (\\>18 years old) irrespective of socioeconomic background\n* Adult patients (\\>18 years old) with any disease status\n* Adult patients (\\>18 years old) with any disease duration\n* Adult patients (\\>18 years old) under any treatment scheme (e.g. non-steroidal anti-inflammatory drugs, steroids, disease-modifying anti-rheumatic drugs including biologics)\n\nExclusion Criteria:\n\n* Adult patients (\\>18 years old) with concurrent infectious disease\n* Adult patients (\\>18 years old) in pregnancy\n* Patients under 18 years of age",{"count":104,"type":23},"Rheumatic diseases constitute a group of non-communicable diseases characterized by chronic inflammation. The most common autoimmune rheumatic diseases (ARDs) are rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, myositis, Sjogren's syndrome and systemic scleroderma. These autoimmune disorders lead to joint destruction and adversely influence the human body systemically. One of their characteristics is comorbidity, since patients usually suffer also from other pathologies such as cardiovascular diseases and obesity. In addition, their treatment requires a combination of both biological and conventional pharmaceutical interventions as well as other parameters such as physical activity programs, nutrition, and the use of smart electronic devices. Therefore, the ARDs burden health systems worldwide. Apart from the physiological manifestations of ARDs, specific changes are observed at the cellular and molecular level. A common biochemical\u002Fmolecular symptom of these diseases is oxidative stress. This condition leads to the disturbance of blood and tissue redox status due to the excessive production of free radicals. Given that free radicals are highly reactive moieties with strong oxidative capacity against biomolecules (i.e., proteins, lipids, DNA), they compromise the efficacy of the intrinsic antioxidant mechanisms and, finally, induce the disruption of redox homeostasis. However, there is no sufficient data linking the levels of redox status of patients with the progression of ARDs over time. Indeed, the onset and symptoms of ARDs are intertwined with the disruption of the patient redox homeostasis and the induction of oxidative stress. Concurrently, the absence of a completely effective pharmaceutical treatment emerges the need for the adoption of novel biomarkers for monitoring the severity of the symptoms and the evolution of ARDs in general. To that end, this study aims at first to investigate the blood redox status of patients with ARDs. Thus, specific redox biomarkers will be evaluated in the blood of patients in three time points (i.e., at Days 1, 180 and 360), and they will be associated with the clinical manifestations of their diseases. The ultimate goal is to clarify whether these biomarkers could putatively exert clinical significance, namely whether they could constitute an additional tool for the monitoring of the progression of these diseases in clinical practice.",[224,225,226,227],"Inflammatory Joint Diseases","Rheumatoid Arthritis (RA)","Psoriatic Arthritis (PsA)","Ankylosing Spondylitis (AS)",[229,230,231,232,233],"Rheumatoid arthritis","Psoriatic arthritis","Ankylosing spondylitis","Oxidative stress","Antioxidants","2026-04-22",{"date":206,"type":36},{"date":237,"type":36},"2025-10-06",{"date":239,"type":23},"2026-10",{"name":42,"class":43},{"id":242,"slug":243,"hasResults":12,"nctId":244,"briefTitle":245,"officialTitle":246,"acronym":247,"eligibilityCriteria":248,"healthyVolunteers":17,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":249,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":251,"conditions":252,"keywords":257,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":234,"lastUpdatePostDateStruct":270,"startDateStruct":271,"completionDateStruct":273,"leadSponsor":275,"locationsCount":276},"100635861","systematic-examination-of-health-inequalities-documentation-patterns-and-determinants-100635861","NCT07558187","Systematic Examination of Health Inequalities: Documentation, Patterns, and Determinants","Assessment of Lifestyle Parameters and Biomarkers of Biochemistry and Physiology to Address Health Inequalities: An Exploratory Cohort Study","CHANCE","Inclusion Criteria:\n\n* Adults (\\>18 years of age)\n* All healthy individuals who reside in rural and urban areas\n* All patients with non-communicable diseases who reside in rural and urban areas\n* Patients with opioid use disorders under medication for addiction treatment with methadone and buprenorphine\n* Individuals incarcerated in correctional facilities\n\nExclusion Criteria:\n\n* Minors (\\\u003C18 years of age)\n* Individuals with communicable diseases",{"count":250,"type":23},2000,"The existence of social inequalities is a major global issue and a salient challenge for the European Union. During COVID-19 pandemic, health disparities became more evident. Indeed, the low-income residents in several European countries, including Greece, had limited access to the healthcare system for several reasons. In addition, vulnerable populations, with patients suffering from opioid use disorders and incarcerated individuals being among them, do not have the same chances regarding health services, compared to the general population. According to the World Health Organization, physical activity is a key non-pharmaceutical intervention for both prevention of chronic non-communicable diseases and address of social health inequalities. Thus, this study will focus on specific population groups of the Region of Thessaly, Greece, who have limited access to healthcare services. It aims, primarily, to the assessment of demographic characteristics (i.e., body mass index, alcohol consumption, smoking, educational level etc), which are fundamental parameters for the assessment of health inequalities. Secondly, quality of life, physical activity levels and biomarkers in the level of Biochemistry (i.e., blood oxidative stress and inflammation) and Physiology (i.e., cardiorespiratory fitness, body composition) will be collected a well. All data will be integrated into an interactive digital platform that will be accessible by any putative stakeholder in the area of health system or administration. Based on scientifically robust data and evidence-based findings, the research team of the project will draft recommendations and guidelines that will be communicated to all stakeholders. To that end, the problem of limited access to health system that the examined populations face, will be highlighted and targeted actions and policies are expected to be adopted by local (i.e., in the province of Thessaly) and national (i.e., Greek) authorities. In this respect, non-pharmaceutical interventions and guidelines will be proposed towards the trajectory of holistically approaching the issue of health inequalities.",[253,254,255,256],"Non-communicable Diseases (NCD)","Addiction to Opioids","Incarceration","Opioid-use Disorders",[258,259,260,261,262,232,233,263,264,265,266,267,268,269],"Health inequalities","Physical activity\u002Fexercise","Demographics","Quality of life","Heroin craving","Resting energy expenditure","Body composition","Alcohol","Body mass index","Smoking","Cardiorespiratory fitness","Opioid use disorders",{"date":184,"type":36},{"date":272,"type":36},"2026-03-10",{"date":274,"type":23},"2028-12",{"name":42,"class":43},5,{"id":278,"slug":279,"hasResults":12,"nctId":280,"briefTitle":281,"officialTitle":282,"acronym":4,"eligibilityCriteria":283,"healthyVolunteers":17,"sex":52,"minAge":128,"maxAge":284,"enrollmentInfo":285,"targetDuration":4,"studyType":24,"phases":287,"briefSummary":288,"conditions":289,"keywords":291,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":297,"lastUpdatePostDateStruct":298,"startDateStruct":300,"completionDateStruct":302,"leadSponsor":303,"locationsCount":44},"100635638","sideritis-supplementation-and-performance-100635638","NCT07555288","Sideritis Supplementation and Performance","The Effect of Sideritis as Supplement on Performance","Inclusion Criteria:\n\n* Healthy Individuals aged 18-40 years\n\nExclusion Criteria:\n\n* Musculoskeletal Injury\n* Dietary supplements\n* Medication","40 Years",{"count":286,"type":23},12,[26],"The purpose of this study is to examine the effect of sideritis consumption on physiological and performance indicators in adult subjects and compare it with the control trial.",[290],"Athletic Performance",[292,293,294,295,296],"sideritis","Extract","Performance","Blood lactate","Blood Glusose","2026-04-21",{"date":299,"type":36},"2026-04-29",{"date":301,"type":23},"2026-04-25",{"date":38,"type":23},{"name":42,"class":43},{"id":305,"slug":306,"hasResults":12,"nctId":307,"briefTitle":308,"officialTitle":309,"acronym":310,"eligibilityCriteria":311,"healthyVolunteers":17,"sex":52,"minAge":128,"maxAge":102,"enrollmentInfo":312,"targetDuration":4,"studyType":24,"phases":314,"briefSummary":315,"conditions":316,"keywords":323,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":119},"100632159","title-icarus---psycho-physiological-profiling-of-low-and-high-heat-resilient-individuals-100632159","NCT07510061","Title: ICARUS - Psycho-physiological Profiling of Low and High Heat-resilient Individuals","Physiological Phenotyping","ICARUS","Study Population\n\nHealthy adult volunteers residing in Denmark (Northern Europe) or Greece (Southern Europe).\n\nInclusion Criteria\n\n* Age 18-65 years (or your protocol-specific age range)\n* Healthy as determined by medical history screening questionnaire\n* Able to provide written informed consent\n* Able to complete heat exposure and light exercise protocol\n* No heat acclimatization or extensive sun exposure in the previous 4 weeks\n* Fitzpatrick skin type I-IV (if applicable for UV testing)\n* Willing to undergo blood sampling, urine collection, and skin biopsy\n\nExclusion Criteria\n\n* History of cardiovascular, metabolic, neurological, or dermatological disease\n* History of heat-related illness (e.g., heat stroke)\n* Use of medications affecting thermoregulation or cardiovascular function\n* Smoking or substance abuse\n* Pregnancy or breastfeeding\n* Abnormal ECG or uncontrolled hypertension\n* Recent severe sunburn or UV treatment\n* Contraindications to skin biopsy\n* Inability to tolerate heat exposure during screening",{"count":313,"type":23},80,[26],"The escalating environmental heat-stress associated with global warming is a societal challenge with large and potential harmful consequences for humans. Excess morbidity and mortality during heat waves provides strong evidence for fatal outcomes. However, it is unclear why some people are particularly vulnerable and get sick from hyperthermia, while others adapt and tolerate exposure.\n\nThe Icarus project aims to provide a psycho-physiological framework for improved mitigation of the health threats associated with global warming. Combining expertise in integrative thermal physiology, pharmacology, photobiology, psychology and machine learning, we will collaborate on comprehensive cross-scientific studies using controlled lab-exposure combined with investigations in ecological settings including vulnerable and highly tolerant people across populations from northern to southern Europe.\n\nAdvanced algorithms will be developed to generate personalized alerts and advising based on behavioral patterns, psychological profiling, predicted vulnerability and willingness to adopt resilience-building strategies.\n\nGlobal warming is projected to continue towards the end of the 21st century and constitutes an increasing threat to human health unless we as individuals and collectively become better in preventing acute effects, as well as devise sustainable strategies to limit further anthropogenic warming of the climate system. Acutely, improved guidance is important for both individual and public health, where Icarus aims at providing a highly improved basis for preventing heat-related disease, advising or nudging people towards pro-health behavior, including smarter use of technologies to mitigate heat stress, or adjusting medication to reduce adverse effects during heat events. In support of the sustainability agenda, our framework also forms a novel basis for developing advising algorithms relevant for optimization of climate change mitigation policy-making.",[317,318,319,320,321,322],"Skin Cancer","Heat Tolerance","Heat-related Illness","Hyperthermia","Heat Stress","Ultraviolet Radiation-Related Skin Damage",[321,324,325,326,320,327,328,329,330,331,332,333,334,335,336],"Heat-Related Illness","Heat Vulnerability","Heat Intolerance","Environmental Heat Exposure","Thermal Stress","Ultraviolet Radiation Exposure","Skin DNA Damage","Cardiovascular Strain (Heat-Induced)","Cognitive Impairment (Heat-Induced)","Occupational Heat Stress","Climate Change and Health","Heat Resilience","Heat Acclimatization","2026-03-27",{"date":339,"type":36},"2026-04-03",{"date":341,"type":36},"2025-11-01",{"date":343,"type":23},"2027-04-30",{"name":42,"class":43},{"id":346,"slug":347,"hasResults":12,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":351,"eligibilityCriteria":352,"healthyVolunteers":17,"sex":52,"minAge":4,"maxAge":4,"enrollmentInfo":353,"targetDuration":4,"studyType":24,"phases":355,"briefSummary":356,"conditions":357,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":359,"lastUpdatePostDateStruct":360,"startDateStruct":362,"completionDateStruct":364,"leadSponsor":366,"locationsCount":44},"100625259","colonoscopy-training-with-or-without-artificial-intelligence-among-endoscopy-residents-100625259","NCT07420309","Colonoscopy TRaining With or Without Artificial INtelligence Among Endoscopy Residents","Colonoscopy Training With or Without Artificial Intelligence Among Endoscopy Residents: a Randomized Controlled Study","c-TRAINER","Inclusion Criteria:\n\n* Trial participants: Endoscopy trainees at any time of their training, with at least one year of training ahead without previous structured exposure to CADe during their training.\n\nRecruited patient population: Adult patients undergoing diagnostic, screening, or surveillance colonoscopy will be included.\n\n1. Provision of signed and dated informed consent form understand the risks and benefits of the study\n2. Aged ≥18 years old\n3. Able to read and write in the provided language.\n4. Participants capable to provide written informed consent and comply with the trial protocol.\n\nExclusion Criteria:\n\n* Trial participants: Endoscopy trainees after their basic training, during the last year of training or with systematic exposure to CADe.\n\nRecruited patient population:\n\n1. Patients with a known contraindication for biopsy, bowel obstruction or perforation,\n2. Pregnant or lactating females\n3. Known polyposis syndromes, or who had a history of inflammatory bowel disease (IBD), CRC, or colorectal surgery.\n4. Any patient whose cecum is not reached and who were highly suspected of having polyposis syndromes, IBD, intestinal tuberculosis, or CRC.\n5. Incomplete bowel preparation (segmental Boston Bowel Preparation Score \\\u003C2, or total \\\u003C6)",{"count":354,"type":23},10,[26],"Type of study: Randomized controlled study\n\nInvestigated Procedure: Artificial Intelligence Software for Polyp Detection in Colonoscopy training\n\nTrial participants: Endoscopy trainees during their training with at least one year of training ahead and no previous structured exposure to CADe\n\nObjectives:\n\nPrimary: Adenoma Miss Rate (AMR) in the end of the first year of training for each group and after the crossover.\n\nSecondary: Further endoscopists-related parameters will be recorded and compared between the two arms: PDR, ADR, aADR, PMR, withdrawal time, CIR, AEs\n\nThe investigators will be asked, when possible, to follow-up the patients until they have their next colonoscopy or a diagnosis of CRC to assess for interval cancer.",[358],"Colonoscopy Training","2026-02-11",{"date":361,"type":36},"2026-02-19",{"date":363,"type":23},"2026-02-01",{"date":365,"type":23},"2027-07-01",{"name":42,"class":43},{"id":368,"slug":369,"hasResults":12,"nctId":370,"briefTitle":371,"officialTitle":372,"acronym":373,"eligibilityCriteria":374,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":375,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":377,"conditions":378,"keywords":380,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":384,"lastUpdatePostDateStruct":385,"startDateStruct":386,"completionDateStruct":388,"leadSponsor":390,"locationsCount":391},"100621595","external-validation-of-vvi-100621595","NCT07372664","External Validation of VVI","External Validation of the Volume-Velocity Index for Weaning Prediction: a Multicenter Observational Study","E-VVI","Inclusion Criteria:\n\n* Mechanically ventilated patients for more than 48h\n* First Spontaneous breathing trial\n* Deemed as ready to undergo weaning by the treating physician, according to published readiness criteria (DOI: 10.1183\u002F09031936.00010206)\n\nExclusion Criteria:\n\n* pregnant patients\n* preexisting diaphragmatic disease or injury\n* tracheostomy",{"count":376,"type":23},100,"Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation.\n\nIn this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases:\n\n1. during pressure support ventilation with 5\u002F5,\n2. during pressure support ventilation with 8\u002F0,\n3. during t-tube or pressure support ventilation with 0\u002F0. All of these phases are ventilatory modalities widely used during weaning from mechanical ventilation.\n\nThe investigators will evaluate whether VVI can predict accurately the weaning outcome.",[379],"Weaning Mechanical Ventilation",[381,382,383],"weaning","mechanical ventilation","ultrasound","2026-02-08",{"date":359,"type":36},{"date":387,"type":36},"2025-12-28",{"date":389,"type":23},"2026-09",{"name":42,"class":43},3,{"id":393,"slug":394,"hasResults":12,"nctId":395,"briefTitle":396,"officialTitle":397,"acronym":4,"eligibilityCriteria":398,"healthyVolunteers":12,"sex":52,"minAge":399,"maxAge":199,"enrollmentInfo":400,"targetDuration":4,"studyType":24,"phases":402,"briefSummary":403,"conditions":404,"keywords":409,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":416,"lastUpdatePostDateStruct":417,"startDateStruct":419,"completionDateStruct":421,"leadSponsor":423,"locationsCount":44},"100621866","digital-physiotherapy-for-pediatric-chronic-suppurative-lung-diseases-100621866","NCT07376187","Digital Physiotherapy for Pediatric Chronic Suppurative Lung Diseases","Digital Physiotherapy Services in the Management of Pediatric Chronic Suppurative Lung Diseases: A Randomized Controlled Trial","Inclusion Criteria\n\n* children aged 6 to 12 years old\n* clinically stable with an absence of pulmonary exacerbation four weeks prior to the study's recruitment\n* adherence to attend regular medical follow-up from a pediatric pulmonologist every three months\n\nExclusion Criteria:\n\n* Cystic fibrosis\n* Immunodeficiency or asthma as their primary condition\n* Clinical evidence of cardiovascular, neuromuscular, metastatic, or psychiatric comorbidities, and neuromuscular or musculoskeletal impairments that affect mobility and the ability to follow instructions\n* Medical history of lung transplant\n* Participation in other rehabilitation programs, or attendance at regular physiotherapy ACTs sessions (\\>10 sessions in a 3-month period)\n* Lack access to the internet (e.g., no smartphone, tablet, or laptop)\n* Inability to use technological devices","6 Years",{"count":401,"type":23},32,[26],"This is a prospective, single-center, two-arm (1:1), assessor-blinded, randomized controlled clinical trial that will be conducted in collaboration with the outpatient clinic of the third Pediatric Pulmonology Unit, \"Attikon\" University Hospital of Athens in Greece. The aim of the study is to investigate the effects of applying digital physiotherapy services in the management of specific clinical outcomes in children with chronic suppurative lung diseases, other than cystic fibrosis. The research question is whether airway clearance techniques and exercise training that are performed remotely using digital health services (DHSs) can improve functional and exercise capacity, as well as compliance with ACTs, compared to usual care. The intervention program includes airway clearance techniques (ACTs), as well as aerobic and strengthening exercises that can be implemented easily in an online setting at home with minimal equipment. The duration of the program will be 12 weeks, and the prescribed weekly regimen will consist of 50-minute remote sessions: two synchronous, supervised sessions conducted via the Vsee platform, and a minimum of one asynchronous, unsupervised session. Children will be encouraged to maintain daily adherence to the exercise protocol.",[405,406,407,408],"Chronic Suppurative Lung Disease","Protracted Bacterial Bronchitis","Primary Ciliary Dyskinesia (PCD)","Non Cystic Fibrosis Bronchiectasis",[410,411,412,413,414,415],"chronic suppurative lung diseases","digital health services","pediatric","physiotherapy","remote","website","2026-01-28",{"date":418,"type":36},"2026-01-30",{"date":420,"type":23},"2026-05-01",{"date":422,"type":23},"2028-08-31",{"name":42,"class":43},{"id":425,"slug":426,"hasResults":12,"nctId":427,"briefTitle":428,"officialTitle":428,"acronym":429,"eligibilityCriteria":430,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":431,"targetDuration":4,"studyType":24,"phases":432,"briefSummary":433,"conditions":434,"keywords":440,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":444,"startDateStruct":446,"completionDateStruct":448,"leadSponsor":450,"locationsCount":44},"100622161","acceptability-adherence-and-impact-on-the-bioavailability-of-iron-and-zinc-of-the-dietary-supplements-goodphyte-ib-defense-and-goodphyte-immunity-in-adults-with-chronic-diseases-100622161","NCT07380022","Acceptability, Adherence, and Impact on the Bioavailability of Iron and Zinc of the Dietary Supplements Goodphyte IB Defense and Goodphyte Immunity in Adults With Chronic Diseases.","PHYTASE","Inclusion Criteria:\n\n* Crohn's disease: Patients in remission, with a stable type of pharmacological treatment over the past 3 months and a stable dosage during the last month.\n* Ulcerative colitis: Patients in remission, with a stable type of pharmacological treatment over the past 3 months and a stable dosage during the last month.\n* Hypertension: Patients with systolic blood pressure of 130-139 mmHg or diastolic blood pressure of 80-89 mmHg, who maintain blood pressure within these ranges through lifestyle modifications, without active symptoms (e.g., headaches, dizziness), and not receiving antihypertensive medication.\n* Anemia: Patients with hemoglobin \\\u003C12 g\u002FdL, serum iron \\\u003C40 μg\u002FdL, and ferritin \\\u003C15 ng\u002FmL for women, and hemoglobin \\\u003C13 g\u002FdL, serum iron \\\u003C40 μg\u002FdL, and ferritin \\\u003C30 ng\u002FmL for men. Absence of severe clinical consequences. Presence of fatigue, weakness, or dizziness, which is usually manageable.\n* Multiple sclerosis: Patients in remission, with a stable type of pharmacological treatment over the past 3 months and a stable dosage during the last month.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Current use of antibiotics or antibiotic use within the past month\n* Current use of other probiotic, prebiotic, or synbiotic supplements\n* Current use of iron and\u002For zinc supplements\n* Change in the type of therapeutic regimen (pharmacotherapy) within the past three months\n* Change in the dosage of the therapeutic regimen (pharmacotherapy) within the past month\n* Renal or hepatic disease\n* Inability to provide informed consent (including individuals \\\u003C18 years of age)\n* Insufficient understanding of the Greek language",{"count":376,"type":23},[26],"The primary objective of the present postdoctoral research is to evaluate the acceptability and adherence of two dietary supplements containing microbial phytase, Goodphyte IB Defense and Goodphyte Immunity, in adult individuals with chronic diseases, namely Idiopathic Inflammatory Bowel Diseases (IIBD)-that is, Crohn's disease (CD) or Ulcerative Colitis (UC)-Arterial Hypertension (AH), Anemia (AN), or Multiple Sclerosis (MS).\n\nSecondarily, this study will investigate potential changes in iron and zinc absorption following phytase supplementation in these individuals and, consequently, possible changes in their quality of life.",[435,436,437,438,439],"IBD","Hypertension (HTN)","Multiple Sclerosis","Anemia","Colitis Ulcerative",[441,442,429],"ACCEPTABILITY","DIETARY SUPPLEMENT","2026-01-23",{"date":445,"type":36},"2026-02-02",{"date":447,"type":36},"2025-07-09",{"date":449,"type":23},"2026-02-28",{"name":42,"class":43},{"id":452,"slug":453,"hasResults":12,"nctId":454,"briefTitle":455,"officialTitle":456,"acronym":457,"eligibilityCriteria":458,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":459,"targetDuration":4,"studyType":24,"phases":460,"briefSummary":461,"conditions":462,"keywords":464,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":443,"lastUpdatePostDateStruct":468,"startDateStruct":469,"completionDateStruct":471,"leadSponsor":472,"locationsCount":44},"100622160","acceptability-and-adherence-to-different-dosing-regimens-of-the-multistrain-probiotic-vivomixx-460-neo-9-in-adults-receiving-antibiotic-therapy-100622160","NCT07380009","Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy.","Acceptability and Adherence to Different Dosing Regimens of the Multistrain Probiotic Vivomixx® 460 Neo 9 in Adults Receiving Antibiotic Therapy: a Randomized, Open-label Clinical Trial.","VIVOMIXX 460","Inclusion Criteria:\n\n* Men and women aged over 18 years\n* Initiation of oral antibiotic therapy lasting more than 3 days\n* History of diarrhea during previous antibiotic treatment\n* Eligible antibiotics include: (a) amoxicillin with clavulanic acid, (b) clindamycin, and (c) second- or third-generation cephalosporins\n* Willingness to provide informed consent to participate in the study\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Age under 18 years\n* Diagnosis of a chronic autoimmune disease (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriasis)\n* Diagnosis of type I or type II diabetes\n* Renal or hepatic disease\n* Current use of immunosuppressive medications\n* Current use of other supplements, probiotics, prebiotics, or synbiotics\n* Use of antibiotics within the past month\n* Use of laxatives or antidiarrheal medications within the past 2 weeks\n* Pre-existing diarrhea within the past 2 weeks\n* Self-reported allergy to any component of the probiotic\n* Psychological conditions affecting the ability to provide informed consent (e.g., dementia, psychosis, substance use)\n* Gastrointestinal surgery within the past 6 months",{"count":22,"type":23},[26],"This open-label interventional study aims to evaluate the acceptability and adherence of adult participants to the multistrain probiotic Vivomixx® 460 Neo 9 when administered concurrently with antibiotic therapy. Participants are randomized to receive one of two dosing regimens: a low daily dose or a high daily dose. The study will assess the effects of these regimens on the prevention of antibiotic-associated diarrhea (AAD), gastrointestinal symptoms, and patient adherence and acceptability. The results are intended to provide evidence to optimize the clinical use of probiotics alongside antibiotics.",[463],"Antibiotic Therapy",[465,466,467],"antibiotic","probiotic","vivomixx",{"date":445,"type":36},{"date":470,"type":36},"2025-12-12",{"date":38,"type":23},{"name":42,"class":43},{"id":474,"slug":475,"hasResults":12,"nctId":476,"briefTitle":477,"officialTitle":478,"acronym":4,"eligibilityCriteria":479,"healthyVolunteers":17,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":480,"targetDuration":4,"studyType":24,"phases":481,"briefSummary":482,"conditions":483,"keywords":485,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":488,"lastUpdatePostDateStruct":489,"startDateStruct":490,"completionDateStruct":492,"leadSponsor":494,"locationsCount":44},"100620794","evaluation-of-the-acceptability-of-a-multi-strain-probiotic-supplement-smile-probio-45b-in-healthy-adults-100620794","NCT07362251","Evaluation of the Acceptability of a Multi-strain Probiotic Supplement (Smile Probio 45B) in Healthy Adults","Evaluation of the Acceptability of a Multi-strain Probiotic Supplement (Smile Probio 45B) in Healthy Adults: an Open-label Pilot Study","Inclusion Criteria:\n\n* Men and women aged over 18 years\n* Body Mass Index (BMI) \\>18 kg\u002Fm² and \\\u003C30 kg\u002Fm²\n* No use of antibiotics in the past month\n* Willingness to provide informed consent\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding\n* Age under 18 years\n* Diagnosis of a chronic autoimmune disease (e.g., Crohn's disease, ulcerative colitis, rheumatoid arthritis, psoriasis)\n* Diagnosis of type I or II diabetes\n* Current use of immunosuppressive medications\n* Current use of antibiotics or use of antibiotics within the past month\n* Current use of other supplements such as probiotics, prebiotics, or synbiotics\n* Kidney or liver disease\n* Self-reported allergy to any component of the probiotic\n* Psychological conditions affecting the ability to provide informed consent (e.g., dementia, psychosis, substance use)\n* Gastrointestinal surgery within the last 6 months",{"count":22,"type":23},[26],"The goal of this clinical trial is to examine the compliance and acceptability of the probiotic Smile Probio 45B in healthy adults, as well as its effect on gastrointestinal symptoms, fatigue levels, and quality of life.\n\nSpecifically, the study examines the effect of probiotic intake on improving health-related quality of life, reducing self-reported gastrointestinal symptoms such as bloating, as well as regulating stool consistency and frequency. In addition, its impact on participants' self-reported energy levels is investigated, with a particular emphasis on reducing fatigue symptoms.\n\nParticipants will:\n\n* take 1 capsule daily (with a main meal) during the first and second week of the intervention, and 3 capsules daily (after each main meal) during the third and fourth week of the intervention, for a total duration of 30 days.\n* complete a three-day food record on a weekly basis.\n* record their daily bowel habits, including the number of bowel movements and their consistency\u002Fform, according to the Bristol Stool Chart, which will be provided to them.\n* complete questionnaires assessing health-related quality of life \\[WHOQOL-BREF (World Health Organization Quality of Life)\\],a health status questionnaire \\[EQ-5D (EuroQol-5D)\\] and a questionnaire evaluating energy levels and fatigue \\[Chalder Fatigue Scale (CFQ)\\].\n* complete, at baseline and at the end of each intervention week a weekly symptom assessment questionnaire.\n* undergo body composition assessment at the beginning, midpoint, and end of the study.\n* complete an acceptability questionnaire at the end of the intervention.",[484],"Healthy",[486,466,487],"acceptability","multi strain","2026-01-21",{"date":443,"type":36},{"date":491,"type":36},"2025-05-19",{"date":493,"type":23},"2026-03-30",{"name":42,"class":43},{"id":496,"slug":497,"hasResults":12,"nctId":498,"briefTitle":499,"officialTitle":500,"acronym":501,"eligibilityCriteria":502,"healthyVolunteers":17,"sex":52,"minAge":128,"maxAge":503,"enrollmentInfo":504,"targetDuration":4,"studyType":24,"phases":506,"briefSummary":507,"conditions":508,"keywords":511,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":526,"lastUpdatePostDateStruct":527,"startDateStruct":529,"completionDateStruct":531,"leadSponsor":533,"locationsCount":44},"100613099","dance-mindfulness-intervention-for-well-being-in-recreational-adults-100613099","NCT07262177","Dance-Mindfulness Intervention for Well-Being in Recreational Adults","Mindful Embodied Movement: A 12-Week Modern Dance-Mindfulness Intervention and Mixed-Methods Randomized Controlled Trial in Recreational Adult Dancers","DanceMind","Inclusion Criteria:\n\n* Adults aged 18 years and older\n* Enrolled in dance classes (preferring modern\u002Fcontemporary) at participating schools for at least 6 months prior to study enrollment\n* Able and willing to attend weekly sessions for 12 consecutive weeks (minimum 70% attendance required)\n* Able to understand and complete study questionnaires in Greek language\n* Able to engage in moderate-intensity movement and dance activities without acute medical contraindications\n* Written informed consent provided\n* Willing to be randomly assigned to intervention or waitlist control group\n\nExclusion Criteria:\n\n* Musculoskeletal or neurological conditions limiting safe participation in moderate-intensity movement (e.g., acute injury, severe arthritis, neurological disease affecting coordination\u002Fbalance)\n* Current severe psychological distress or mental health crisis requiring immediate clinical intervention (screened via DASS-21; cutoff: Severe or Extremely Severe on any subscale)\n* Pregnancy or planning pregnancy during the 12-week study period\n* Current concurrent participation in other psychological interventions, therapy, or mind-body programs (Pilates, yoga, tai-chi, other mindfulness-based interventions)\n* Unable to attend ≥70% of weekly sessions due to scheduling constraints or anticipated absences\n* Inability to provide informed consent or complete questionnaires in Greek\n* Acute medical illness or hospitalization within 2 weeks of study start\n* History of substance abuse disorder currently active or untreated","60 Years",{"count":505,"type":23},160,[26],"This 12-week study protocol outlines a randomized controlled trial designed to evaluate the effectiveness of a Dance-Mindfulness intervention integrating Modern Theatre Dance with mindfulness-based embodied practices to enhance psychological wellbeing, nervous system regulation, and embodied awareness in adults. The intervention combines: (1) polyvagal-informed breath-movement synchronization (nasal breathing, grounding); (2) ISTD (Imperial Society of Teachers of Dancing) Modern Theatre Dance technique progression and dance movements (Grades 2-4); (3) nervous system regulation through somatic practices; and (4) phenomenological reflection via weekly journaling and post-session integration.\n\nStudy Design: Parallel-assignment randomized controlled trial (approx. N=320; n=160 intervention, n=160 waitlist control). Randomization uses computer-generated block randomization (block sizes 4-6).\n\nOutcomes: Perceived stress, mindfulness psychological wellbeing (happiness, life satisfaction), emotional regulation, social connection, movement confidence.\n\nQualitative Component: Phenomenological interviews and weekly reflective journals from subsample (approx. n=20) analyzed via Interpretative Phenomenological Analysis and Reflexive Thematic Analysis.\n\nIntervention Delivery: 90-100 minute weekly sessions delivered over 12 weeks by qualified facilitator(s) trained in Modern Theatre Dance, mindfulness (≥3 years personal practice, MBSR, yoga or equivalent), trauma-informed care, and group facilitation. Sessions include 8 structured components: breath-grounding (9-10 min), technical dance work (14-15 min), conditioning (9-10 min), break-settling (4-5 min), rhythm improvisation (8-9 min), choreographed sequences (15-17 min), cool-down-integration (8-9 min), and phenomenological journaling (10-20 min).\n\nSafety \\& Fidelity: Structured facilitator guidelines, session checklists, weekly supervision, adverse event protocols, and external fidelity monitoring ensure protocol integrity. Classroom size: 15-18 participants per session.\n\nData Collection: Baseline (Week 0), mid-intervention (Week 6 only for qualitative), post-intervention (Week 12), and optional 1-3 month follow-up. Intent to treat analysis and mixed-effects modeling for between-group comparisons. Population: Adults (age 18+) seeking wellbeing enhancement through recreation or stress reduction. Eligible participants without acute mental health crisis. Primary Purpose: Health promotion and mental health improvement through nervous system regulation, embodied awareness, and psychosocial wellbeing enhancement.",[509,510],"Healthy Volunteers","Health Promotion",[512,513,514,515,516,517,518,519,520,521,522,523,524,525],"somatic education","embodied phenomenology","community-based dance education","dance movement therapy","psychological wellbeing","mindfulness","creative movement","interoception","autonomic regulation","embodied awareness","emotional regulation","vagal regulation","stress reduction","motor learning","2026-01-01",{"date":528,"type":36},"2026-01-06",{"date":530,"type":36},"2025-09-02",{"date":532,"type":23},"2026-05-31",{"name":42,"class":43},{"id":535,"slug":536,"hasResults":12,"nctId":537,"briefTitle":538,"officialTitle":539,"acronym":4,"eligibilityCriteria":540,"healthyVolunteers":17,"sex":52,"minAge":541,"maxAge":542,"enrollmentInfo":543,"targetDuration":4,"studyType":105,"phases":4,"briefSummary":544,"conditions":545,"keywords":550,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":555,"lastUpdatePostDateStruct":556,"startDateStruct":558,"completionDateStruct":560,"leadSponsor":561,"locationsCount":44},"100567384","lower-extremity-dynamometry-assessment-in-neurotypical-children-100567384","NCT06667492","Lower Extremity Dynamometry Assessment in Neurotypical Children","Reliability and Validity of Lower Extremity Dynamometry Assessment in Neurotypical Children","Inclusion Criteria:\n\n* typically developing children,\n* between the ages of 5 and 16 years,\n* have the capacity for voluntary motor control\n\nExclusion Criteria :\n\n* undergone any treatment or intervention that could impact neuromuscular performance, such as surgery or medication use,\n* experienced a recent injury\n* demonstrating low levels of compliance during assessments are not included in the study.","5 Years","16 Years",{"count":56,"type":23},"The purpose of this study is to assess the reliability (intra-rater and inter-rater) and criterion validity (using a Cybex isokinetic dynamometer as the reference) of the K-Pull (traction) dynamometer for evaluating lower limb function in children with neurotypical development.",[546,547,548,549],"Force Measurement","Children","Lower Limb","Assessment Tool",[551,552,553,554],"dynamometry","lower limb","assessment","child","2025-12-19",{"date":557,"type":36},"2025-12-29",{"date":559,"type":36},"2024-09-20",{"date":389,"type":23},{"name":42,"class":43},{"id":563,"slug":564,"hasResults":12,"nctId":565,"briefTitle":566,"officialTitle":567,"acronym":4,"eligibilityCriteria":568,"healthyVolunteers":17,"sex":52,"minAge":53,"maxAge":569,"enrollmentInfo":570,"targetDuration":4,"studyType":24,"phases":572,"briefSummary":573,"conditions":574,"keywords":577,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":579,"lastUpdatePostDateStruct":580,"startDateStruct":582,"completionDateStruct":584,"leadSponsor":585,"locationsCount":44},"100608076","redox-status-and-exercise-training-induced-adaptations-100608076","NCT07196852","Redox Status and Exercise Training-induced Adaptations","Effects of N-acetylcysteine on Biological Responses to High-intensity Interval Training in Adults With Overweight\u002FObesity","Inclusion Criteria:\n\n* BMI 25-35 kg\u002Fm2\n* Free of musculoskeletal injuries\n* Free of chronic non-communicable diseases\n* Do not receive any drug therapy\n* Do not receive dietary supplements\n* Normal menstrual cycle (for females)\n* Non smokers\n\nExclusion Criteria:\n\n* NAC intolerance\n* Bleeding disorders\n* Kidney disease\n* Asthma\n* Usage of blood thinners and\u002For angina medication","45 Years",{"count":571,"type":23},60,[26],"Excess fat accumulation is a key feature of overweight and obesity that is mainly driven by nutrient overload and insufficient physical activity. White adipose tissue displays lipid overload and hypertrophy accompanied by macrophages infiltration, hypoxia, inflammation and excess production of reactive oxygen species (ROS). An inflammatory response and ROS production are also evident in other metabolism regulating tissues and organs such as skeletal muscle, liver, pancreas and hypothalamus, contributing to a chronic inflammatory state, redox status disturbances and metabolic complications. There is overwhelming evidence showing that adults with overweight\u002Fobesity exhibit lower glutathione (GSH) levels in blood erythrocytes, skeletal muscle cells and subcutaneous and visceral adipose tissue cells. GSH, a tripeptide consisting of the amino acids glutamate, cysteine and glycine, is the most abundant thiol-containing antioxidant in the human body and has been, recently, characterized as a novel therapeutic target for the treatment of numerous chronic diseases, due to its potent intracellular redox buffering capacity. Interestingly, lower GSH levels have been associated with diet-induced weight loss resistance, while enhancement of GSH levels through N-acetylcysteine (NAC) supplementation reduces markers of oxidative stress, inflammation, insulin resistance, hypertension, endothelia dysfunction and improves vitamin D metabolism. NAC is a thiol donor that elicits antioxidant effects by (i) directly scavenging ROS and (ii) providing reduced cysteine through deacetylation, which supports the biosynthesis of endogenous GSH via the activity of γ-glutamylcysteine synthase. The aim of this study is to investigate whether NAC supplementation can enhance the exercise training-induced improvements on physical fitness and metabolic health in adult men and women with overweight\u002Fobesity.",[575,576],"Overweight (BMI > 25)","Obesity",[63,62,578,64],"N-acetylcysteine","2025-12-09",{"date":581,"type":36},"2025-12-16",{"date":583,"type":36},"2025-09-22",{"date":211,"type":23},{"name":42,"class":43},{"id":587,"slug":588,"hasResults":12,"nctId":589,"briefTitle":590,"officialTitle":591,"acronym":592,"eligibilityCriteria":593,"healthyVolunteers":17,"sex":594,"minAge":128,"maxAge":53,"enrollmentInfo":595,"targetDuration":4,"studyType":24,"phases":596,"briefSummary":597,"conditions":598,"keywords":600,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":605,"lastUpdatePostDateStruct":606,"startDateStruct":608,"completionDateStruct":610,"leadSponsor":611,"locationsCount":44},"100612205","analysis-of-bioenergetics-and-fatigue-responses-in-basketball-team-100612205","NCT07250555","Analysis of Bioenergetics and Fatigue Responses in Basketball (TEAM)","sTudy of the bioEnergetics and fAtigue Responses of a Basketball gaMe: The TEAM Trial","TEAM","Inclusion Criteria:\n\n* Health status: were free of recent musculoskeletal injuries and\u002For illnesses (≥ 8 months before the study).\n* Not consuming ergogenic supplements\u002Fmedications (≥ 6 months before the study)\n* Not smokers\n\nExclusion Criteria:\n\n* Completion of the pre-determined participation time during the experimental game.\n* Completion of all field measurements.\n* Completion of all pre-determined sampling points for biological tissue.","MALE",{"count":56,"type":23},[26],"The aims of the study are:\n\n1. To examine skeletal muscle and blood metabolites during an official basketball game and to relate those to skeletal muscle performance during and after the game.\n2. To investigate whether skeletal muscle and blood metabolites are related to game-induced fatigue.\n3. To relate field activity during a basketball game with the responses of skeletal muscle and blood metabolites.\n4. To investigate how blood lactate reflects muscle lactate concentration during a basketball game.\n5. To determine whether temporary fatigue develops during a basketball game. game.",[599],"Metabolic Stress",[601,602,603,604],"basketball","performance","blood metabolites","skeletal muscle metabolism","2025-11-22",{"date":607,"type":36},"2025-11-26",{"date":609,"type":36},"2025-05-30",{"date":449,"type":23},{"name":42,"class":43},{"id":613,"slug":614,"hasResults":12,"nctId":615,"briefTitle":616,"officialTitle":617,"acronym":618,"eligibilityCriteria":619,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":4,"enrollmentInfo":620,"targetDuration":4,"studyType":24,"phases":621,"briefSummary":622,"conditions":623,"keywords":627,"overallStatus":205,"whyStopped":4,"lastUpdateSubmitDate":633,"lastUpdatePostDateStruct":634,"startDateStruct":636,"completionDateStruct":638,"leadSponsor":640,"locationsCount":44},"100607765","the-effect-of-attention-distraction-on-the-adherence-to-exercise-in-chronic-low-back-pain-patients-100607765","NCT07192809","The Effect of Attention Distraction on the Adherence to Exercise, in Chronic Low Back Pain Patients.","Chronic Non-Specific Low Back Pain: Investigating the Effectiveness of a Dual-Task Program as an Attention Distraction Strategy","PAINLESS","Inclusion Criteria:\n\n* Age \\> 18 years\n* Chronic non-specific low back pain (≥3 months)\n* No physical therapy or structured exercise program in the last 3 months\n* Willingness to use the attention distraction application (for the AD-APP group)\n* Completion of the International Physical Activity Questionnaire (IPAQ)\n\nExclusion Criteria:\n\n* History of spinal surgery\n* Neurological conditions affecting movement\n* Regular use of pain relief medication within the past two weeks\n* Pregnancy\n* Severe psychological disorders that may affect compliance",{"count":571,"type":23},[26],"This randomized controlled trial aims to investigate whether the use of an attention distraction application during exercise increases patient adherence to exercise programs in chronic non-specific low back pain (CNSLBP). In addition, the study will examine whether higher adherence to exercise leads to improved outcomes in pain levels, functional capacity, kinesiophobia, quality of life, central sensitization, and pain catastrophizing.",[624,625,626],"Chronic Low Back Pain (CLBP)","Distraction Methods","Adherence to Care",[628,629,630,631,632],"chronic low back pain","adherence","distraction","divided attention","chronic non specific low back pain","2025-09-17",{"date":635,"type":36},"2025-09-25",{"date":637,"type":23},"2025-09-20",{"date":639,"type":23},"2026-01-31",{"name":42,"class":43},{"id":642,"slug":643,"hasResults":12,"nctId":644,"briefTitle":645,"officialTitle":646,"acronym":4,"eligibilityCriteria":647,"healthyVolunteers":12,"sex":52,"minAge":128,"maxAge":648,"enrollmentInfo":649,"targetDuration":4,"studyType":24,"phases":651,"briefSummary":652,"conditions":653,"keywords":656,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":661,"lastUpdatePostDateStruct":662,"startDateStruct":664,"completionDateStruct":666,"leadSponsor":668,"locationsCount":44},"100586359","antecolic-versus-retrocolic-gastrojejunostomy-during-whipples-procedure-100586359","NCT06914349","Antecolic Versus Retrocolic Gastrojejunostomy During Whipple's Procedure","Antecolic Versus Retrocolic Gastrojejunostomy Following Pancreaticoduodenectomy: a Prospective Randomised Study","Inclusion Criteria:\n\n* Age over 18 years old\n* Elective pancreaticoduodenectomy\n* Signed consent form\n\nExclusion Criteria:\n\n* Age under 18 years old\n* Patients who are participants in other trials that may affect the results of this study\n* Patients who do not consent to participate in the study","80 Years",{"count":650,"type":23},76,[26],"Aim: This randomized clinical study aims to compare occurrence of DGE in patients undergoing either antecolic or retrocolic gastrojejunostomy following pancreaticoduodenectomy.\n\nMethods: Participants of this study will be patients undergoing pylorus preserving pancreaticoduodenectomy at the Surgical Department of the University Hospital of Larissa. Patients will be randomized to undergo either an antecolic or a retrocolic gastrojejunostomy and the occurrence of DGE will then be compared between the two groups. Individuals younger than 18 or older than 75 years old, as well as patients who do not consent to participate in this trial, will be excluded.\n\nExpected results: Based on available literature, antecolic gastrojejunostomy may be related with a lower incidence of DGE, without a statistically significant difference between the two methods. We aim to show if one of the two methods of gastrointestinal reconstruction (antecolic versus retrocolic) affects DGE.",[654,655],"Pancreatic Cancer Resectable","Pancreas Neoplasms",[657,658,659,660],"Gastrojejunostomy","Whipple's","Antecolic","Retrocolic","2025-06-05",{"date":663,"type":36},"2025-06-06",{"date":665,"type":36},"2025-03-30",{"date":667,"type":23},"2029-03-31",{"name":42,"class":43},{"id":670,"slug":671,"hasResults":12,"nctId":672,"briefTitle":673,"officialTitle":674,"acronym":675,"eligibilityCriteria":676,"healthyVolunteers":17,"sex":594,"minAge":128,"maxAge":677,"enrollmentInfo":678,"targetDuration":4,"studyType":24,"phases":679,"briefSummary":680,"conditions":681,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":683,"lastUpdatePostDateStruct":684,"startDateStruct":686,"completionDateStruct":688,"leadSponsor":690,"locationsCount":44},"100544325","effects-of-protein-and-nac-co-ingestion-on-skeletal-muscle-recovery-100544325","NCT06367413","Effects of Protein and NAC Co-ingestion on Skeletal Muscle Recovery","Effects of Whey Protein and N-acetylcysteine Co-ingestion on Skeletal Muscle Recovery Following Exercise-induced Muscle Damage.","PRoNAC","Inclusion Criteria:\n\n* Free of asthma, kidney disease, bleeding disorders, peptic ulcers.\n* Free of musculoskeletal injuries and limitations.\n* Abstain from dietary energy restriction.\n* Do not use medication such as anti-inflammatory drugs, antibiotics, antihypertensive drugs or anticoagulants.\n* Do not use dietary supplements such as protein, carbohydrate, antioxidants, vitamins etc.\n* Free of N-acetylcysteine intolerance.\n* Non-smokers.\n* Abstain from alcohol throughout the study.\n\nExclusion Criteria:\n\n* Presence of asthma, kidney disease, bleeding disorders, peptic ulcers.\n* Musculoskeletal injuries and limitations.\n* Dietary energy restriction.\n* Use of anti-inflammatory drugs, antibiotics, antihypertensive drugs or anticoagulants.\n* Use of dietary supplements such as protein, carbohydrate, antioxidants, vitamins etc.\n* N-acetylcysteine intolerance.\n* Smoking.\n* Alcohol consumption during the study.","27 Years",{"count":56,"type":23},[26],"Previous evidence suggests that though N-acetylcysteine (NAC) supplementation following eccentric exercise-induced muscle damage disrupts the skeletal muscle's repair and remodelling process at 8 days of recovery, it attenuates substantially the decline of skeletal muscle performance during the first 48 hours of recovery. The enhanced performance capacity during the first phase of recovery in response to NAC supplementation might be attributed to the altered redox status in skeletal muscle as a consequence of the NAC-mediated elevation of reduced glutathione (GSH) levels. The rise in GSH results in a redox-dependent attenuation of immune cell mobilisation and reduction of oxidative stress response, leading to a blunted rise of muscle damage and inflammatory markers during the first 2-3 days of recovery. However, following exercise-induced muscle damage, protein synthesis increases in skeletal muscle over the next 24-48 hours to support its repair process, and thus protein supplementation might accelerate the recovery process by enhancing the protein synthetic response. Therefore, the present study aims at investigating for first time the combined effect of NAC and whey protein supplementation on the short-term (during the first 72 hours) recovery process of skeletal muscle following damaging exercise (eccentric exercise) and compared it with the well-documented efficacy of NAC supplementation. The results of this study might be particularly useful for athletes, such as those in soccer and basketball, that participate in 3 games or intense training sessions during the same macrocycle with only 48-72 hours of recovery in-between.",[682],"Aseptic Muscle Injury","2025-05-31",{"date":685,"type":36},"2025-06-04",{"date":687,"type":36},"2024-04-08",{"date":689,"type":23},"2025-07-30",{"name":42,"class":43},""]