[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Trás-os-Montes and Alto Douro\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":70},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,2,0,[8,43],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":15,"eligibilityCriteria":16,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":4,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":31,"lastUpdatePostDateStruct":32,"startDateStruct":35,"completionDateStruct":37,"leadSponsor":39,"locationsCount":42},"100620672","multimodal-physical-exercise-program-physical-exercise-for-psychosis-for-people-with-psychosis-treated-with-long-acting-injectable-antipsychotics-100620672",false,"NCT07360665","Multimodal Physical Exercise Program (Physical Exercise for Psychosis) for People With Psychosis Treated With Long-Acting Injectable Antipsychotics","PEP - Physical Exercise for Psychosis: A Study Protocol","PEP","Inclusion Criteria:\n\n* Age 18 years or older;\n* Clinical diagnosis of psychosis;\n* Currently undergoing treatment with long-acting injectable antipsychotics (LAIs);\n* Follow-up at the Antipsychotic Clinic of ULSTMAD;\n* Certificate of autonomy issued by the treating psychiatrist, confirming the participant's capacity to engage in the study procedures;\n* Ability to provide written informed consent, either personally or through a legal representative;\n* (Experimental group only) Residence within a reasonable distance from the physical exercise intervention site to allow attendance at supervised sessions.\n\nExclusion Criteria:\n\n* Attendance below 85% of the supervised exercise sessions (experimental group);\n* Failure to complete the four main assessment time points;\n* Withdrawal or lack of informed consent at any stage of the study;\n* Not prescribed long-acting injectable antipsychotics (LAIs);\n* Not affiliated with or followed at the Antipsychotic Clinic of ULSTMAD.","ALL","18 Years",{"count":20,"type":21},44,"ESTIMATED","INTERVENTIONAL",[24],"NA","People with psychotic disorders, such as schizophrenia, often experience significant difficulties in daily functioning, physical health, and quality of life. Long-acting injectable antipsychotics are an important part of treatment, but they can be associated with metabolic side effects and reduced physical fitness. Physical exercise has shown potential benefits for mental and physical health in this population; however, structured exercise programs implemented in real-world psychiatric services are still limited.\n\nThe purpose of this study is to evaluate the feasibility and clinical impact of a structured, multimodal physical exercise program for adults with psychosis who are receiving long-acting injectable antipsychotic treatment. The study aims to determine whether participation in a supervised exercise program can improve physical functioning, psychological well-being, and selected biological markers related to brain health and metabolism.\n\nThis study will be conducted in an outpatient psychiatric setting in Portugal and will include adults diagnosed with psychosis who are currently treated with long-acting injectable antipsychotics. Participants will be allocated to either an exercise group or a control group receiving usual care. The exercise program will last 24 weeks and will include aerobic, strength, mobility, and flexibility exercises, with supervised sessions conducted by qualified professionals.\n\nParticipants will be assessed at baseline, during the intervention, after completion of the program, and at follow-up. Assessments will include measures of physical function, body composition, psychological well-being, quality of life, and blood-based biomarkers such as brain-derived neurotrophic factor, dopamine, serotonin, and metabolic indicators.\n\nThe main hypothesis of this study is that individuals who participate in the physical exercise program will show improvements in physical function, mood, and overall well-being compared with those receiving usual care alone. The results of this study are expected to provide practical evidence to support the integration of structured physical exercise as an adjunct to routine psychiatric care for people with psychosis.",[27,28,29],"Psychotic Disorders","Schizophrenia Spectrum Disorders (SSD)","Severe Mental Illness","RECRUITING","2026-04-28",{"date":33,"type":34},"2026-04-29","ACTUAL",{"date":36,"type":34},"2026-01-01",{"date":38,"type":21},"2026-11-30",{"name":40,"class":41},"University of Trás-os-Montes and Alto Douro","OTHER",1,{"id":44,"slug":45,"hasResults":11,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":4,"eligibilityCriteria":49,"healthyVolunteers":11,"sex":50,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":22,"phases":53,"briefSummary":54,"conditions":55,"keywords":58,"overallStatus":30,"whyStopped":4,"lastUpdateSubmitDate":61,"lastUpdatePostDateStruct":62,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":69},"100547634","personalised-multicomponent-exercise-programme-in-peripheral-arterial-disease-100547634","NCT06410521","Personalised Multicomponent Exercise Programme in Peripheral Arterial Disease","Personalisation of Non-surgical Treatment in Peripheral Arterial Disease Using a Multicomponent Exercise Approach","Inclusion Criteria:\n\n* Diagnosed with clinically stable PAD;\n* An ankle-brachial index (ABI) between 0.41-0.90 at rest in one or both lower limbs;\n* Mild to moderate claudication, corresponding to Fontaine Stage IIa and IIb;\n* A history of ambulatory leg pain;\n* Ambulatory leg pain confirmed by treadmill test;\n* Able to provide written consent.\n\nExclusion Criteria:\n\n* Noncompressible, calcified, tibial arteries (resting ABI ≥ 1.4);\n* Use of medication that could influence claudication (e.g. Cilostazol or Pentoxifylline) 3 months prior to investigation;\n* Previous intervention (e.g. balloon angioplasty, stenting, bypass, exercise programme);\n* Inability to walk on a treadmill at a speed of 3.2 km\u002Fh (2 mph);\n* Participation in the past 3 months in a clinical trial or exercise program;\n* Asymptomatic PAD determined from the medical history;\n* Exercise limited by factors other diseases or conditions than intermittent claudication;\n* Angina pectoris, congestive heart failure, chronic obstructive pulmonary disease, severe arthritis, or limb amputation.","MALE",{"count":52,"type":21},40,[24],"Peripheral arterial disease (PAD) is characterised as an atherosclerotic disease, most common in the lower limbs (aortoiliac, femoropopliteal, and infrapopliteal arterial segments), which causes a decrease in blood flow to the areas adjacent to and posterior to the affected area. Intermittent claudication (IC) is the most common symptom in this disease that appears with exertion and relieves with rest, causing fatigue, cramps, discomfort, or pain in the lower limbs due to limited blood flow to the affected muscles. Supervised physical exercise has emerged as the first line of intervention in improving the symptoms of intermittent claudication and disease progression, and in the last decade there has been an exponential increase in the use of wearable technologies to monitor dose-response. However, the approach used is still simplistic because it is not personalised. In other words, patients with similar diagnoses and symptoms get the same treatment, without personalising the stimulus according to their exercise responses and level of adaptation. With this in mind, this study aims to monitoring the real-time response of a multicomponent exercise programme (cardiovascular and resistance training) to personalise the dose-response, and use artificial intelligence models to gather and analyse vast amounts of data towards grouping\u002Fdifferentiating based on individual responses. The main hypothesis is that a supervised multicomponent exercise programme will improve the functional capacity of patients with PAD in a cluster personalised approach.",[56,57],"Peripheral Arterial Disease","Intermittent Claudication",[59,60],"Peripheral arterial disease","Supervised multicomponent exercise programme","2025-06-24",{"date":63,"type":34},"2025-06-27",{"date":65,"type":34},"2025-06-20",{"date":67,"type":21},"2027-12",{"name":40,"class":41},3,""]