[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Turku\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":396},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,14,0,[8,45,71,101,129,157,177,200,223,261,291,318,345,375],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":4,"eligibilityCriteria":14,"healthyVolunteers":11,"sex":15,"minAge":16,"maxAge":17,"enrollmentInfo":18,"targetDuration":4,"studyType":21,"phases":22,"briefSummary":24,"conditions":25,"keywords":28,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":33,"lastUpdatePostDateStruct":34,"startDateStruct":37,"completionDateStruct":39,"leadSponsor":41,"locationsCount":44},"100642741","stronger-together-antenatal-depressive-symptoms---prevalence-and-digital-treatment-100642741",false,"NCT07639164","Stronger Together: Antenatal Depressive Symptoms - Prevalence and Digital Treatment","Inclusion Criteria:\n\n* fluent in written and spoken Finnish or Swedish\n* access to computer or mobile phone with internet\n* between 12 and 22 weeks pregnant\n* screening and baseline score on the EPDS ≥10 points\n\nExclusion Criteria:\n\n* lifetime history of psychotic disorder (e.g. schizophrenia, schizoaffective disorder, bipolar disorder, psychotic depression)\n* active suicidal ideation\n* severe substance abuse or dependence\n* participates in another intervention study aiming at treating the symptoms of antenatal depression","FEMALE","18 Years","55 Years",{"count":19,"type":20},1000,"ESTIMATED","INTERVENTIONAL",[23],"NA","The main objective of the current research project is to evaluate the usability, satisfaction of the antenatal iCBT program including telephone coaching for antenatal and postnatal depressive symptoms and collect nationally representative data on population-based screening of antenatal depressive and anxiety symptoms. The overarching hypothesis is that iCBT, with easy access and affordability, is user friendly and well accepted. In addition to examining the treatment response by questionnaires, we will study the infant development comprehensively as well as potential physiological changes associated with antenatal depression or its treatment.",[26,27],"Depression \u002F Major Depressive Disorder","Antenatal Depression",[29,30,31],"Digital intervention","Cognitive Behaviour Therapy","Antenatal depression","NOT_YET_RECRUITING","2026-06-05",{"date":35,"type":36},"2026-06-10","ACTUAL",{"date":38,"type":20},"2026-08-01",{"date":40,"type":20},"2030-12-30",{"name":42,"class":43},"University of Turku","OTHER",1,{"id":46,"slug":47,"hasResults":11,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":51,"eligibilityCriteria":52,"healthyVolunteers":11,"sex":53,"minAge":16,"maxAge":54,"enrollmentInfo":55,"targetDuration":4,"studyType":21,"phases":57,"briefSummary":59,"conditions":60,"keywords":4,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":64,"lastUpdatePostDateStruct":65,"startDateStruct":66,"completionDateStruct":68,"leadSponsor":70,"locationsCount":4},"100640621","phase-4-post-operative-spinal-block-duration-and-pain-relief-after-hip-replacement-surgery-comparing-single-shot-spinal-ropivacaine-and-bupivacaine-100640621","NCT07631091","Post-Operative Spinal Block Duration and Pain Relief After Hip Replacement Surgery: Comparing Single-Shot Spinal Ropivacaine and Bupivacaine","Post-Operative Analgesia and Spinal Block Duration Following Total Hip Arthroplasties: Comparison of Single-Shot Intrathecal Ropivacaine and Bupivacaine in a Randomized Double-Blinded Controlled Study","ROBUTHA","Inclusion Criteria:\n\n* 18 - 80 years of age\n* Scheduled for a primary elective total hip arthroplasty\n* Patient must be a candidate for same day discharge\n* Informed consent understood and signed\n* Patient is 160 - 186 cm tall\n\nExclusion Criteria:\n\n* Scheduled bilateral THA\n* Contraindication to or failed spinal anesthesia\n* Allergy or contraindication to NSAIDs (e.g. chronic kidney disease)\n* Diabetes requiring insulin medication\n* Preoperative chronic use of illegal substances\n* Renal insufficiency (eGFR \\\u003C 60)\n* Unstable psychiatric conditions\n* Severe neurological disorder\n* Cognitive deficiencies preventing informed consent\n* Language barrier preventing completion of study\n* Pregnancy or breastfeeding\n* Chronic pain syndrome","ALL","80 Years",{"count":56,"type":20},176,[58],"PHASE4","This study aims to determine whether isobaric ropivacaine is more suitable than isobaric bupivacaine for spinal anesthesia in outpatient total hip arthroplasty (THA). The study will evaluate whether ropivacaine allows faster recovery of sensory and motor function while still providing adequate surgical anesthesia and postoperative pain control. Additional aims are to assess the effects of the anesthetic technique on same-day discharge rates, postoperative recovery, urinary retention, opioid consumption, and patient satisfaction after outpatient THA.",[61,62,63],"Hip Osteoarthritis","Hip Arthroplasty Replacement","Postoperative Pain After Ambulatory Surgery","2026-06-02",{"date":33,"type":36},{"date":67,"type":20},"2026-06",{"date":69,"type":20},"2028-05",{"name":42,"class":43},{"id":72,"slug":73,"hasResults":11,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":77,"eligibilityCriteria":78,"healthyVolunteers":11,"sex":53,"minAge":4,"maxAge":4,"enrollmentInfo":79,"targetDuration":4,"studyType":21,"phases":81,"briefSummary":82,"conditions":83,"keywords":85,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":93,"lastUpdatePostDateStruct":94,"startDateStruct":96,"completionDateStruct":98,"leadSponsor":100,"locationsCount":44},"100599430","a-financial-social-work-intervention-for-families-with-complex-financial-difficulties-finsoc-100599430","NCT07084389","A Financial Social Work Intervention for Families With Complex Financial Difficulties (FinSoc)","A Financial Social Work Intervention for Families With Complex Financial Difficulties - A Randomised Controlled Trial","FinSoc","Inclusion Criteria:\n\n* Client status in child welfare services, family social work, or adult social work\n* Within the past six months, the client has brought up one or more of the following challenges in managing their finances during their contact with social services: (1) Difficulties paying bills, housing-related expenses, or repaying debts on time, (2) Difficulties meeting the basic needs of family members (e.g. food, medication, clothing) (3) A perceived lack of sufficient knowledge, skills, or competence to manage financial matters (4) Feelings of anxiety or stress related to financial situation.\n* There is at least one underage child in the family. In cases of shared custody, the child must reside in the household for an average of at least half of the time in each calendar month.\n\nExclusion Criteria:\n\n* There is an ongoing crisis or life situation in the family that, in the assessment of the social worker, prevents commitment to the intervention process.\n* There is an active criminal proceeding within the family.\n* The parents do not speak Finnish (all project materials are in Finnish, and there are no resources available to provide translations into other languages).",{"count":80,"type":20},88,[23],"As of 2022, about 12% of children in Finland lived in poverty. Many of these families face not only a lack of money but also stress, low confidence in managing finances, and limited access to financial guidance. This study aims to support these families by improving their financial skills and well-being through a practical and research-based program.\n\nThe intervention includes five sessions with a trained social service professional, focusing on budgeting, financial decision-making, emotions around money, and the role of money in relationships. The goal is to reduce financial anxiety, improve knowledge, and build confidence in managing finances. The sessions also aim to help families talk more openly about money and set realistic financial goals.\n\nTo test effectiveness, a randomized controlled trial (RCT) will be conducted. Families are randomly assigned to either the intervention group (receiving the FinSoc program) or a control group (receiving regular social work services and, after final measurements, a material package to promote financial capability).\n\nAt least 88 participants-families with at least one child under 18 and facing financial difficulties-will take part. Information will be collected at three time points: before the intervention, after it ends, and three months later. Outcomes include financial literacy, financial anxiety, economic self-efficacy, and health-related quality of life, measured with self-rating scales in questionnaires.\n\nIn addition to questionnaires, interviews will be conducted with a sample of families and social workers to explore their experiences-what worked, what could be improved, and how the sessions were received. This qualitative feedback will guide future development.\n\nFormative evaluation involves feedback from families before and after each session, covering topic clarity, session usefulness, and experiences with the techniques. For fidelity assessment, social workers will report after each session on adherence to the planned approach and tool use.\n\nThe FinSoc program is offered through public and private social service providers. It was developed and is being implemented by an interdisciplinary team with expertise in financial social work, social policy, and mental health.\n\nThe study aims to improve families' everyday lives, inform social work practices, and contribute to knowledge on social and economic well-being.",[84],"Financial Difficulties",[86,87,88,89,90,91],"financial difficulties","social work","poverty","financial literacy","economic self-efficacy","financial anxiety","RECRUITING","2026-05-08",{"date":95,"type":36},"2026-05-13",{"date":97,"type":36},"2025-07-01",{"date":99,"type":20},"2026-10-30",{"name":42,"class":43},{"id":102,"slug":103,"hasResults":11,"nctId":104,"briefTitle":105,"officialTitle":106,"acronym":107,"eligibilityCriteria":108,"healthyVolunteers":11,"sex":53,"minAge":16,"maxAge":4,"enrollmentInfo":109,"targetDuration":111,"studyType":112,"phases":4,"briefSummary":113,"conditions":114,"keywords":117,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":121,"lastUpdatePostDateStruct":122,"startDateStruct":123,"completionDateStruct":125,"leadSponsor":127,"locationsCount":128},"100398242","troponin-fragmentation-in-myocardial-injury-study-100398242","NCT04465591","TROPOnin FRAGMentation in Myocardial Injury Study","Troponin T Fragmentation in the Assessment of Myocardial Injury Study","Tropo-Fragm","Inclusion Criteria:\n\n* Troponin T fragmentation sample collected from a recruited patient.\n\nExclusion Criteria:\n\n* Age \\\u003C18",{"count":110,"type":20},1500,"1 Year","OBSERVATIONAL","Troponin T (TnT) is a part of the troponin protein complex that principally exists in cardiac and skeletal muscle cells and is widely used as diagnostic biomarker for myocardial injury and, thus, myocardial infarction (MI). Elevated TnT levels can, however, be observed in the presence of other clinical conditions such as heart failure, sepsis and kidney failure and the contemporary high-sensitivity TnT test may yield false positive results when performing diagnostics for suspected MI in these patients.\n\nRecent data have demonstrated that in the presence of MI, TnT gradually undergoes fragmentation into smaller fragments. It has been suggested that in the presence of e.g. chronic kidney disease or physical exercise the released TnT is predominantly in the form of smaller fragments.\n\nHowever, the clinical significance of TnT fragmentation is unknown and, thus, we sought to investigate the prevalence of fragmentation of TnT in different patient cohorts.",[115,116],"Acute Myocardial Infarction Type 1","Myocardial Injury",[118,119,120],"Troponin","myocardial injury","myocardial infarction","2026-05-04",{"date":93,"type":36},{"date":124,"type":36},"2020-04-02",{"date":126,"type":20},"2028-12-31",{"name":42,"class":43},2,{"id":130,"slug":131,"hasResults":11,"nctId":132,"briefTitle":133,"officialTitle":133,"acronym":134,"eligibilityCriteria":135,"healthyVolunteers":11,"sex":53,"minAge":16,"maxAge":4,"enrollmentInfo":136,"targetDuration":4,"studyType":21,"phases":138,"briefSummary":139,"conditions":140,"keywords":142,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":149,"lastUpdatePostDateStruct":150,"startDateStruct":152,"completionDateStruct":154,"leadSponsor":156,"locationsCount":44},"100527554","treatment-of-insomnia-in-primary-care-study-100527554","NCT06149273","Treatment of Insomnia in Primary Care Study","TIP","Inclusion Criteria:\n\n* Insomnia severity index (ISI) score at least 8\n* insomnia symptoms present at least for 3 months\n\nExclusion Criteria:\n\n* diagnosed dementia based on medical records\n* acute suicidality\n* acute psychotic symptoms",{"count":137,"type":20},250,[23],"The goal of this clinical trial is to learn about insomnia treatment among primary care patients with chronic insomnia.\n\nThe main question it aims to answer is:\n\n• Does Sleep School (a therapy for insomnia) work well to decrease harm of insomnia? Participants will attend a group therapy intervention once a week for six weeks.\n\nResearchers will compare Sleep School to treatment as usual (short counselling by an educated nurse) to see if the Sleep School works better than treatment as usual in decreasing the harm of insomnia.",[141],"Insomnia Chronic",[143,144,145,146,147,148],"Cognitive behavioral therapy for insomnia","CBT-I","Primary care","Insomnia severity index","Quality of life","Depressive symptoms","2026-04-30",{"date":151,"type":36},"2026-05-01",{"date":153,"type":36},"2023-12-02",{"date":155,"type":20},"2029-12",{"name":42,"class":43},{"id":158,"slug":159,"hasResults":11,"nctId":160,"briefTitle":161,"officialTitle":161,"acronym":4,"eligibilityCriteria":162,"healthyVolunteers":163,"sex":53,"minAge":164,"maxAge":4,"enrollmentInfo":165,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":167,"conditions":168,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":170,"lastUpdatePostDateStruct":171,"startDateStruct":173,"completionDateStruct":174,"leadSponsor":176,"locationsCount":44},"100623092","understanding-newborn-mother-synchrony-at-home-feasibility-of-remote-monitoring-100623092","NCT07392138","Understanding Newborn-Mother Synchrony at Home: Feasibility of Remote Monitoring","Inclusion Criteria, mothers:\n\n* ability to participate in Finnish\n* Android smart phone available\n\nInclusion Criteria, newborns:\n\n* received informed consent from both parents\u002Fguardians\n* the newborn's health has been stated normal during hospital stay\n* the newborn is \\\u003C 1-month of age\n\nExclusion Criteria, both (mother and newborn):\n\nNot meeting the inclusion criteria",true,"0 Years",{"count":166,"type":20},60,"Parents and newborns influence each other in a dynamic interaction that can be described as synchrony. Synchrony between a newborn and mother refers to the dynamic and reciprocal adaptation between the newborn and mother. In this synchrony, the mother is highly receptive and sensitive to the newborn's signals, feelings, and needs. The aim of this study is to investigate the physiological and behavioral synchrony between newborns and their mothers, and to investigate the connection between maternal heart rate variability and postpartum depression symptoms in the home environment and to evaluate the suitability of remote monitoring devices for use in the home environment.\n\nThe study participants consist of 30 newborns and 30 mothers. The inclusion criteria for newborns are: 1) informed consent from the newborn's parents\u002Fguardians 2) the newborn's health status has been confirmed as normal during hospital monitoring, and 3) the newborn is less than one month old. The inclusion criteria for mothers are: 1) ability to participate in Finnish, and 2) the mother has access to an Android smartphone.\n\nData collection will be carried out using the following remote monitoring methods: Emfit smart mattress, Zoundream Cry analyses technology, Polar Verity Sense sensor, and Empatica EmbracePlus sensor. In addition, data will be collected using background information forms, a maternal stress scale (PSS-4), a diary completed by the mother, a maternal depression questionnaire (EPDS), and questionnaires measuring the suitability of remote monitoring in the home environment, and a thematic interview. In addition, at the end of the data collection phase, the mothers participating in the study will try out the Companion App, which displays sample data on the well-being of newborns, and respond to a questionnaire on the usability of the app.",[169],"Synchrony","2026-04-13",{"date":172,"type":36},"2026-04-16",{"date":170,"type":36},{"date":175,"type":20},"2026-05",{"name":42,"class":43},{"id":178,"slug":179,"hasResults":11,"nctId":180,"briefTitle":181,"officialTitle":181,"acronym":4,"eligibilityCriteria":182,"healthyVolunteers":11,"sex":53,"minAge":164,"maxAge":183,"enrollmentInfo":184,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":185,"conditions":186,"keywords":189,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":193,"lastUpdatePostDateStruct":194,"startDateStruct":195,"completionDateStruct":197,"leadSponsor":199,"locationsCount":44},"100604393","validity-and-algorithm-development-for-detection-of-supraventricular-tachycardia-in-children-a-clinical-pilot-study-100604393","NCT07148934","Validity and Algorithm Development for Detection of Supraventricular Tachycardia in Children-A Clinical Pilot Study","Inclusion Criteria:\n\n* For children in Study(SVT) group:\n\n  1. received informed consent from both parents\u002Fguardians\n  2. the child is treated in the Pediatric wards of Tyks Lighthouse hospital\n  3. the child is between the age of 0-10 years\n  4. the child has diagnosed or suspected SVT.\n* For children in control group:\n\n  1. received informed consent from both parents\u002Fguardians\n  2. the child is treated in the Pediatric wards of Tyks Lighthouse hospital\n  3. the child is between the age of 0-10 years\n  4. child has not diagnosed with SVT\n\nExclusion Criteria:\n\n* All participant groups:\n\n  1. not reaching the inclusion criteria","10 Years",{"count":166,"type":20},"The aim of this study is to evaluate the reliability of smartphone seismocardiography (SCG) and bed-based ballistocardiography (BCG) for detecting supraventricular tachycardia (SVT) in children aged 0-10 years. The performance of these methods will be compared to the gold standard of continuous telemetry ECG recording.",[187,188],"Supraventricular Tachycardia","Atrial Fibrillation (AF)",[187,190,191,192],"Atrial Fibrillation","Seismocardiography","SmartPhone","2026-04-09",{"date":170,"type":36},{"date":196,"type":20},"2026-04",{"date":198,"type":20},"2027-06",{"name":42,"class":43},{"id":201,"slug":202,"hasResults":11,"nctId":203,"briefTitle":204,"officialTitle":204,"acronym":205,"eligibilityCriteria":206,"healthyVolunteers":163,"sex":53,"minAge":207,"maxAge":208,"enrollmentInfo":209,"targetDuration":4,"studyType":21,"phases":211,"briefSummary":212,"conditions":213,"keywords":4,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":215,"lastUpdatePostDateStruct":216,"startDateStruct":218,"completionDateStruct":220,"leadSponsor":222,"locationsCount":44},"100564337","nicotinamide-adenine-dinucleotide-nad-metabolism-in-human-brown-adipose-tissue-100564337","NCT06627868","Nicotinamide Adenine Dinucleotide (NAD+) Metabolism in Human Brown Adipose Tissue","BATNAD","Inclusion Criteria:\n\n* Willingness to provide informed consent to participate in the BATNAD study\n* Must be able to read and speak English\u002FFinnish\u002FSwedish well enough to completely understand the instructions and provide informed consent\n* Age 30-55 (sedentary lifestyle)\n* BMI = 18-25 kg\u002Fm2 (normal-weight subjects)\n* BMI ≥ 28 kg\u002Fm2 and waist circumference more than 100 cm in men and more than 90 cm in women (subjects with obesity)\n\nExclusion Criteria:\n\n* Inability to have PET\u002FCT (claustrophobia, metal implants, recent tattoo including metal components, weight \\> 200 kg)\n* Pregnancy and pregnancy related conditions (postpartum\u002Flactation during the last 12 months, or planning to become pregnant soon)\n* Major alterations in the menstrual cycle (e.g., amenorrhea)\n* Use of nicotine based products\n* Hypo- or hyper- thyroidism (medical history, TSH, T3 or T4 levels out of the normal range)\n* Diabetes mellitus (fasting Hb1Ac \\>6.5% or fasting glycaemia\\> 7.0 mmol\u002F)\n* Abnormal oral glucose tolerance test (2h OGTT \\> 11.1 mmol\u002FL)\n* Hypertension (blood pressure \\> 160\u002F100 mmHg)\n* Abnormal cardiovascular status (arrhythmia and\u002For long QTc in ECG, abnormal cardiac murmur, previous history of cardiovascular disease)\n* Abnormal coagulopathy (e.g., clotting abnormality)\n* Malignancies\n* Immunological, autoimmune and primary\u002Fsecondary immunodeficiency disorders (including or not any active treatment)\n* Virus or bacterial infection (both asymptomatic and symptomatic picture) within the 45 days prior to the study start\n* Vaccination within the 45 days prior to the study start\n* Episode of fever or major surgery, burns and traumas within the month prior to the study start\n* Chronic infections requiring chronic antibiotic or anti-viral treatment\n* Whole blood donation in the last 3 months (\\>400 mL of blood) or plans for blood donation during the entire protocol period\n* Weight change (intentional or not) over the last 6-months more than 5% of body weight, or plan to lose weight during the study\n* Allergy to lidocaine or epinephrine, or other local anaesthetics\n* Previous participation to studies where PET or CT method is used\n* Use of any medication that, in the opinion of local clinician\u002Fresearcher, would negatively impact or mitigate full participation and completion, or could influence the study results. This especially applies to the use of β or α adrenergic receptors agonists\u002Fantagonists (e.g., β-blockers).\n* Any other cardiovascular, pulmonary, orthopaedic, neurologic, psychiatric or other conditions that, in the opinion of the local clinician\u002Fresearcher, would preclude participation and successful completion of the protocol, or that would negatively impact or mitigate participation in and completion of the protocol","30 Years","65 Years",{"count":210,"type":20},68,[23],"A fully functional brown fat helps maintain a healthy weight and decreases the risk of metabolic diseases such as type II diabetes (T2DM). Unfortunately, in human adults, the functionality of brown fat declines with age, and it is one of the reasons for gaining unhealthy weight, particularly around the waistline (central obesity). Currently, scientists do not clearly understand the reasons for the decline in brown fat functionality. It is possible that the decline in the availability of the molecule Nicotinamide Adenine Dinucleotide (NAD+), which is central to several metabolic processes, plays a role in the decline in brown fat metabolism. This project will clarify whether NAD+-based molecular-targeted therapies for the enhancement of whole-body insulin sensitivity and brown fat metabolism will be successful in adult humans, which will eventually be an important target for reducing the development of obesity and its comorbidities such as T2DM.",[214],"Obesity, Abdominal","2026-02-14",{"date":217,"type":36},"2026-02-18",{"date":219,"type":36},"2024-11-20",{"date":221,"type":20},"2027-08-31",{"name":42,"class":43},{"id":224,"slug":225,"hasResults":11,"nctId":226,"briefTitle":227,"officialTitle":228,"acronym":229,"eligibilityCriteria":230,"healthyVolunteers":163,"sex":53,"minAge":16,"maxAge":4,"enrollmentInfo":231,"targetDuration":4,"studyType":21,"phases":233,"briefSummary":234,"conditions":235,"keywords":242,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":253,"lastUpdatePostDateStruct":254,"startDateStruct":256,"completionDateStruct":258,"leadSponsor":260,"locationsCount":44},"100615519","comparing-mixed-reality-video-based-and-instructor-led-training-for-nasogastric-tube-insertion-in-nursing-students-100615519","NCT07293663","Comparing Mixed Reality, Video-Based, and Instructor-Led Training for Nasogastric Tube Insertion in Nursing Students","Comparing Mixed Reality, Video-Based, and Instructor-Led Training in Nasogastric Tube Insertion: A Randomized Controlled Trial Assessing Learning Outcomes, Usability, and Student Experiences in Nursing Education","NURSE-TRAIN","Inclusion Criteria:\n\n* First-year nursing student\n* Performing nasogastric tube (NGT) insertion for the first time\n* No prior theoretical education or pre-material on NGT insertion procedure\n\nExclusion Criteria:\n\n* Previous nursing education (e.g., practical nurse qualification)\n* Diagnosis of epilepsy\n* Presence of a pacemaker",{"count":232,"type":20},160,[23],"This study explores how nursing students learn to insert a nasogastric tube (NGT), a common but potentially risky clinical procedure. The goal is to compare three different teaching methods:\n\nMixed Reality (MR) glasses with virtual instructions Video-based learning Traditional instructor-led training\n\nThe study investigates which method leads to better learning outcomes, how usable the technologies are, and how students experience MR in their learning.\n\nParticipants will be first-year nursing students with no prior experience in NGT insertion. They will be randomly assigned to one of the three training methods, complete the procedure, and answer questionnaires about their performance and experience. Six months later, they will repeat the procedure to assess long-term learning.",[236,237,238,239,240,241],"Education, Nursing Students","Clinical Competence","Teaching Innovation","Nasogasrtic Tube Insertion","User Experience","Teaching Method",[243,244,245,246,247,248,249,250,251,252],"Nasogastric Tube Insertion","Nursing Education","Mixed Reality","Video-Based Learning","Instructor-Led Training","Meta Quest 3","Nursing Clinical Skills","Randomized Controlled Trial","Nursing Students","Extended Reality in Healthcare","2025-12-06",{"date":255,"type":36},"2025-12-19",{"date":257,"type":36},"2025-02-12",{"date":259,"type":20},"2027-04",{"name":42,"class":43},{"id":262,"slug":263,"hasResults":11,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":163,"sex":53,"minAge":16,"maxAge":269,"enrollmentInfo":270,"targetDuration":4,"studyType":112,"phases":4,"briefSummary":272,"conditions":273,"keywords":276,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":282,"lastUpdatePostDateStruct":283,"startDateStruct":285,"completionDateStruct":287,"leadSponsor":289,"locationsCount":290},"100460660","complex-molecular-etiology-and-cellular-landscape-of-hip-osteoarthritis-100460660","NCT05278520","Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis","Studies on the Complex Molecular Etiology and Cellular Landscape of Hip Osteoarthritis","OASEQ","Inclusion Criteria for the main (OA) study:\n\nCases: Adult patients with osteoarthritis in the hip joint and who are going through an elective total hip arthroplasty.\n\nControls: Non-arthritis adult patients who are going through a trauma-based emergency total hip arthroplasty.\n\n\\----\n\nInclusion Criteria for the Rheumatoid sub-study:\n\nAdult patients with rheumatoid arthritis in the hip joint and who are going through an elective total hip arthroplasty.\n\n\\----\n\nExclusion Criteria:\n\n* The body mass index must be below 35\n* Age \\\u003C 18 or \\> 74\n* The OA patients may not have diabetes, rheumatoid arthritis (RA), or metabolic syndrome.\n\nFor the Rheumatoid sub-study, the exclusion criteria are the same as above except for the RA.","74 Years",{"count":271,"type":20},110,"The purpose of this study is to cast light on the highly complex etiology and cellular landscape of hip osteoarthritis by utilising single-cell and spatial omics.",[274,275],"Osteoarthritis, Hip","Rheumatoid Arthritis",[277,278,279,280,281],"Single-cell RNA sequencing","Spatial transcriptomics","Osteoarthritis","Rheumatoid arthritis","Spatial proteomics","2025-08-18",{"date":284,"type":36},"2025-08-24",{"date":286,"type":36},"2023-01-11",{"date":288,"type":20},"2028-12",{"name":42,"class":43},4,{"id":292,"slug":293,"hasResults":11,"nctId":294,"briefTitle":295,"officialTitle":296,"acronym":4,"eligibilityCriteria":297,"healthyVolunteers":11,"sex":53,"minAge":16,"maxAge":54,"enrollmentInfo":298,"targetDuration":4,"studyType":21,"phases":300,"briefSummary":301,"conditions":302,"keywords":304,"overallStatus":32,"whyStopped":4,"lastUpdateSubmitDate":311,"lastUpdatePostDateStruct":312,"startDateStruct":314,"completionDateStruct":316,"leadSponsor":317,"locationsCount":4},"100601945","minimally-invasive-non--surgical-periodontal-therapy-of-intrabony-defects-healing-patterns-and-smoking-impact-100601945","NCT07117097","Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects: Healing Patterns and Smoking Impact","Minimally Invasive Non- Surgical Periodontal Therapy of Intrabony Defects: Molecular Healing Patterns and the Impact of Smoking on Outcomes","Inclusion Criteria:\n\n* patients with Periodontitis stage III or IV, grades B to C . Each patient will have to present one intrabony defect site ( site with Probing Depth (PD)\\>5mm and radiographic defect depth \\>3mm).\n* participants should be free of any systemic or oral conditions that could affect disease progression or treatment outcomes\n\nExclusion Criteria:\n\n* diabetes\n* hepatic or renal disease\n* history of conditions requiring prophylactic antibiotics\n* anti-inflammatory or anticoagulant therapy the preceding month\n* systemic antibiotic therapy the preceding 3 months\n* history of alcohol or drug abuse\n* self-reported pregnancy or lactation\n* other severe acute or chronic medical or psychiatric condition\n* periodontal treatment within the last 12 months\n* presence of drug-induced gingival overgrowth",{"count":299,"type":20},120,[23],"This study is consisted of two arms. At first, a randomized controlled clinical trial will be conducted. Eighty systematically healthy, non-smoker patients with Periodontitis stage III or IV, grades B to C will be included. Each patient will have to present one intrabony defect site ( site with Probing Depth (PD)\\>5mm and radiographic defect depth \\> or =3mm). The patients will be randomized in two groups, regarding the treatment intervention of the intrabony defects: Group A (conventional Non-Surgical Periodontal Treatment, cNSPT) and Group B (Minimally Invasive Non-Surgical Therapy, MINST). At 5 days and 3 months following intervention, GCF samples will be collected from the intrabony defects in order to assess the molecular healing patterns through intergroup comparisons of inflammation and healing biomarkers. Then two prospective cohort studies will be conducted. The Group B patients will be matched with forty systematically healthy, smoker patients (Group C) with Periodontitis stage III or IV, grades B to C with each one presenting one intrabony defect site ( site with Probing Depth (PD)\\>5mm and radiographic defect depth \\> or =3mm). Then MINST will be performed in the patients of Group C and the two groups will be compared regarding the clinical and radiographic data obtained by clinical and radiographic examinations performed in both groups' intrabony defects pre-treatment and 6 months following the intervention (first prospective study) and regarding the differences in regeneration biomarkers in GCF samples obtained from the intrabony defects 5 days and 3 months post-treatment (second prospective study).",[303],"Periodontitis",[303,305,306,307,308,309,310],"Intrabony defect","GCF","Minimally invasive","smoking","non surgical","bone","2025-08-13",{"date":313,"type":36},"2025-08-19",{"date":315,"type":20},"2025-09",{"date":259,"type":20},{"name":42,"class":43},{"id":319,"slug":320,"hasResults":11,"nctId":321,"briefTitle":322,"officialTitle":323,"acronym":324,"eligibilityCriteria":325,"healthyVolunteers":163,"sex":53,"minAge":16,"maxAge":4,"enrollmentInfo":326,"targetDuration":4,"studyType":21,"phases":328,"briefSummary":329,"conditions":330,"keywords":333,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":337,"lastUpdatePostDateStruct":338,"startDateStruct":340,"completionDateStruct":342,"leadSponsor":344,"locationsCount":44},"100584226","online-training-course-to-improve-evidence-based-leadership-100584226","NCT06886581","Online Training Course to Improve Evidence-based Leadership","Effectiveness of Online Training Course to Improve Evidence-based Leadership Practices: a Cluster Randomised Two-arm Controlled Trial","EVILEAD","Inclusion Criteria:\n\n* have shown their willingness to join the study,\n* unit leaders have an official managerial position at the study organisation,\n* unit have a leaders with a professional licence to work in health or social care sector,\n* unit leaders represent any gender,\n* are able to speak, read and write in Finnish, and\n* have given informed consent to join the study.\n\nExclusion Criteria:\n\n* Those staff members who are off duty during the recruitment period (family leave, long-term sick leave, study leave, or any other reason).",{"count":327,"type":20},300,[23],"The goal of this cluster clinical trial is to evaluate the effectiveness of online training course, targeted to unit leaders to improve staff's evidence-based skills (individual outcomes), EBP implementation (team-based outcomes), and the quality of care (organisational outcomes). Feasibility and fidelity of the intervention will be assessed as well. The main questions it aims to answer are:\n\n1. Does online training course improve staff's evidence-based practice?\n2. Does online training course improve staff's self-esteem and self-efficacy?\n3. Does online training course improve leadership for EBP implementation on organisational level?\n4. Does online training course improve the quality of patient care?\n5. Does online training course reduce staff's absence (sick leaves, intention to leave the ward or hospital)?\n\nParticipants will:\n\n* Participants will join in a seven-months online training course in small group or practice as usual.\n* Seven course modules, read course material, prepare assignments, join in peer discussions.\n* Self-assessment, self-reflection and give course feedback.",[331,332],"Evidence-Based Practice","Leadership",[334,335,336],"cluster randomised trial","evidence-based","leadership","2025-06-10",{"date":339,"type":36},"2025-06-13",{"date":341,"type":36},"2025-06-05",{"date":343,"type":20},"2026-12-31",{"name":42,"class":43},{"id":346,"slug":347,"hasResults":11,"nctId":348,"briefTitle":349,"officialTitle":350,"acronym":351,"eligibilityCriteria":352,"healthyVolunteers":163,"sex":53,"minAge":4,"maxAge":4,"enrollmentInfo":353,"targetDuration":4,"studyType":21,"phases":355,"briefSummary":356,"conditions":357,"keywords":362,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":367,"lastUpdatePostDateStruct":368,"startDateStruct":370,"completionDateStruct":372,"leadSponsor":374,"locationsCount":128},"100581907","power-of-growth---digitally-assisted-intervention-for-the-early-childhood-educators-self-efficacy-teamwork-and-childrens-behavioral-challenges-100581907","NCT06856408","Power of Growth - Digitally Assisted Intervention for the Early Childhood Educators' Self-efficacy Teamwork and Children's Behavioral Challenges.","Power of Growth RCT Study","FinnPoG","Inclusion Criteria:\n\nParticipant is working in a daycare centre team that is participating to the study. Sufficient knowledge in Finnish language.\n\nExclusion Criteria:\n\n\\-",{"count":354,"type":20},64,[23],"This is an RCT study investigating the efficacy of digital intervention focusing on enhancing positive directing skills for teams of early childhood education (ECE) professionals. The aims are to study 1) changes in the ECEs' self-assessed self-efficacy experience in the intervention group compared to the control group; 2) changes in the behavioral challenges of the children in the ECEs' groups assessed by the parents in the intervention group compared to the control group; and 3) changes in the ECEs' guidance methods in the intervention group compared to the control group. We will also study changes in the wellbeing of ECEs and teamwork in both treatment groups. The sample size will consist of approximately 64 teams of ECEs. Hence, altogether there will be approximately 200 study subjects.\n\nThe intervention is aimed at ECE teams and its goal is to strengthen and unify the team positive guidance practices in children's groups. The intervention includes self-learning material and teams online coaching in which the entire team participates simultaneously. The self-material includes 360 videos of everyday situations in the daycare and videos can be watched with VR glasses. The participants practice the skills systematically with their group of children. The duration of the intervention is approximately 12 weeks and team coaching are carried out approximately every two weeks.",[358,359,360,361],"ECE Teachers Self Efficacy","Team Work","Positive Pedagogy","Behavior Problems",[363,364,365,366],"ECE self efficacy","team work","positive pedagogy","behavior problems","2025-02-27",{"date":369,"type":36},"2025-03-04",{"date":371,"type":36},"2025-02-17",{"date":373,"type":20},"2026-05-30",{"name":42,"class":43},{"id":376,"slug":377,"hasResults":11,"nctId":378,"briefTitle":379,"officialTitle":379,"acronym":4,"eligibilityCriteria":380,"healthyVolunteers":11,"sex":53,"minAge":4,"maxAge":4,"enrollmentInfo":381,"targetDuration":4,"studyType":21,"phases":382,"briefSummary":383,"conditions":384,"keywords":386,"overallStatus":92,"whyStopped":4,"lastUpdateSubmitDate":388,"lastUpdatePostDateStruct":389,"startDateStruct":391,"completionDateStruct":393,"leadSponsor":395,"locationsCount":128},"100573763","digital-universal-parenting-program-for-positive-parenting-behaviors-100573763","NCT06750510","Digital Universal Parenting Program for Positive Parenting Behaviors","Inclusion Criteria:\n\n* Guardians having a child aged 3 years participating to annual health checkup in child health clinic.\n* At least one of the guardians is able to understand the languages that intervention is provided in\n\nExclusion Criteria:\n\n* Inability to read Finnish, Swedish, or English, as these are the languages that the intervention is provided in.\n* No internet access",{"count":110,"type":20},[23],"The goal of this study is to evaluate use and feasibility of digitally-delivered universal parenting program, which aims to promote positive parenting among guardians with 3 years-old children.",[385],"Parenting",[387,385],"Parent-Training","2024-12-19",{"date":390,"type":36},"2024-12-27",{"date":392,"type":36},"2022-01-01",{"date":394,"type":20},"2027-12-31",{"name":42,"class":43},""]