[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of West Attica\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":283},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,9,0,[8,48,77,106,138,171,199,226,250],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":14,"acronym":4,"eligibilityCriteria":15,"healthyVolunteers":11,"sex":16,"minAge":17,"maxAge":18,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":23,"briefSummary":25,"conditions":26,"keywords":31,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":38,"lastUpdatePostDateStruct":39,"startDateStruct":42,"completionDateStruct":44,"leadSponsor":45,"locationsCount":4},"100639537","theratogs-effects-on-balance-and-mobility-in-cerebral-palsy-100639537",false,"NCT07618962","TheraTogs Effects on Balance and Mobility in Cerebral Palsy","The Effect of the Dynamic Orthotic Garment TheraTogs on Balance and Functional Mobility of Children and Adolescent With Cerebral Palsy: A Cross-Sectional Clinical Study","Inclusion Criteria\n\n* Diagnosis of unilateral or bilateral spastic Cerebral Palsy\n* GMFCS level I or II\n* MAS level lower than +1\n* Ability to understand and follow instructions\n* Ability to walk without assistive devices\n\nExclusion Criteria\n\n* Use of medications affecting balance\n* Hearing or visual impairments\n* Intellectual disability\n* Botulinum toxin (Botox) injection in the lower limbs within the previous 6 months\n* Severe musculoskeletal deformities\n* Surgery within the previous 6 months\n* Uncontrolled seizures during the previous 6 months","ALL","5 Years","15 Years",{"count":20,"type":21},12,"ESTIMATED","INTERVENTIONAL",[24],"NA","Cerebral Palsy (CP) is the most common cause of childhood disability, with an estimated prevalence of 17 million individuals worldwide. Children and adolescents with CP present impaired postural control and balance, negatively affecting their mobility and functional performance. The use of dynamic orthotic garments may contribute to the improvement of postural control, balance, and functional mobility in children and adolescents with CP.\n\nThe aim of the present study is to investigate the immediate effect of the dynamic orthotic garment TheraTogs on balance and functional mobility in children and adolescents with CP.\n\nIn this cross-sectional pilot study, children and adolescents with CP classified as levels I and II according to the Gross Motor Function Classification System (GMFCS), and with spasticity levels lower than +1 according to the Modified Ashworth Scale, will participate. Balance will be assessed using the Pediatric Balance Scale (PBS), while functional mobility will be evaluated with the Timed Up and Go (TUG) test and the 10 Meter Walk Test (10MWT). Each assessment will be performed twice by each participant, with and without the TheraTogs dynamic orthotic garment, in random order. Statistical analysis will be conducted using SPSS Statistics V29 software, with the level of significance set at p \\\u003C 0.05.",[27,28,29,30],"Cerebral Palsy","THERATOGS","BALANCE","FUCTIONAL MOBILITY",[27,32,33,34,35,36],"children","adolescents","balance","functional mobility","TheraTogs","NOT_YET_RECRUITING","2026-05-30",{"date":40,"type":41},"2026-06-02","ACTUAL",{"date":43,"type":21},"2026-06",{"date":43,"type":21},{"name":46,"class":47},"University of West Attica","OTHER",{"id":49,"slug":50,"hasResults":11,"nctId":51,"briefTitle":52,"officialTitle":52,"acronym":53,"eligibilityCriteria":54,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":56,"targetDuration":4,"studyType":22,"phases":58,"briefSummary":59,"conditions":60,"keywords":62,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},"100637821","effectiveness-of-inspiratory-muscle-training-in-weaning-icu-patients-100637821","NCT07613021","Effectiveness of Inspiratory Muscle Training in Weaning ICU Patients","IMT in weaning","Inclusion Criteria:\n\n* ≥ 72h invasive mechanical ventilation\n* adequate co-operativeness as assessed by 5SQ ≥ 3.\n\nExclusion Criteria:\n\n* terminal condition or palliative care\n* neuromuscular or neurological conditions prior to ICU admission","18 Years",{"count":57,"type":21},45,[24],"Patients in critical condition, due to their prolonged stay in the Intensive Care Unit (ICU), the severity of the underlying disease, and potential adverse effects of hospitalization, may develop serious complications, such as muscle atrophy and weakness, which also affect the respiratory muscles. It is characteristic that within the first 18-69 hours of mechanical ventilation (MV), proteolytic processes occur that lead to rapid atrophy of the diaphragm. Diaphragmatic dysfunction acquired during the ICU stay thus appears to have an adverse effect on weaning from mechanical ventilation, length of ICU stay, length of hospital stay, functional status, quality of life, and mortality within the ICU and the hospital. Inspiratory muscle training (IMT) has been identified as an intervention that could augment weaning, preventing the dedtrimental effects of MV. The purpose of this study is to assess the effect of an IMT protocol in weaning success of ICU patients. Specifically, an electronic device will be used that incorporates a tapered flow resistive technique.",[61],"Mechanically Ventilated ICU Patients",[63,64,65,66],"Inspiratory Muscle training","Weaning","Maximal Inspiratory pressure","Intensive Care Unit","RECRUITING","2026-05-25",{"date":70,"type":41},"2026-05-29",{"date":72,"type":21},"2026-04",{"date":74,"type":21},"2029-12",{"name":46,"class":47},2,{"id":78,"slug":79,"hasResults":11,"nctId":80,"briefTitle":81,"officialTitle":82,"acronym":83,"eligibilityCriteria":84,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":85,"targetDuration":4,"studyType":22,"phases":86,"briefSummary":87,"conditions":88,"keywords":91,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},"100617633","the-effectiveness-of-different-pulse-duration-of-nmes-in-patients-with-pyramidal-tract-related-spasticity-measured-by-neurophysiological-tools-100617633","NCT07321158","The Effectiveness of Different Pulse Duration of NMES in Patients With Pyramidal Tract-related Spasticity Measured by Neurophysiological Tools","The Effectiveness of High Versus Low Pulse Duration Neuromuscular Electrical Stimulation (NMES) in Patients With Upper Limb Pyramidal Tract-related Spasticity Measured by Neurophysiological Tools: A Randomized Controlled Trial","PD-NMES-SPAS","Inclusion Criteria:\n\n* diagnosis by neurologist with first damage of pyramidal tract with upper limb spasticity\n* absence of cognitive dysfunction\n* normal vital signs\n* absence of pharmacological treatment of spasticity (per os pharmacological treatment does not affect spasticity results and was not an exclusion criteria on patients' recruitment).\n\nExclusion Criteria:\n\n* prior neurological damage to pyramidal tract\n* cognitive decline\n* dermatological damages\n* prior musculoskeletal dysfunction on the upper limb with spasticity\n* presence of metallic residues on the spastic upper limb\n* presence of seizures or psychiatric disorders\n* severe malformation or obesity (BMI \\>30kg\u002Fm2)\n* history of coronary or other cardiovascular diseases (deep vein thrombosis, pulmonary embolism)\n* presence of systematic inflammatory disease\n* cancer on terminal stages\n* pregnancy.",{"count":57,"type":21},[24],"Spasticity is a common symptom that affects more than 50% of patients with upper motor neuron lesions due to damage on pyramidal tract. Despite the current pharmacological and physical therapy rehabilitation methods, previous studies have highlighted the beneficial role of Neuromuscular Electrical Stimulation (NMES) on managing upper limb spasticity. However, due to heterogeneity of application parameters there is a lack of a standardized protocol for spasticity management. The aim of the study will be to examine the effects of high versus low pulse duration neuromuscular electrical stimulation on upper limb spasticity on patients with pyramidal tract-related spasticity.\n\nA total of 45 patients will be randomized (1:1:1 ratio) to either high pulse duration NMES (HPD-NMES) or low pulse duration NMES (LPD-NMES) or Control group, receiving the standard of care. Randomization will be performed by an independent investigator, who will allocate participants to one of three groups, using a random number generator, prior to baseline assessment. Each group will receive a 15min-conventional-physiotherapeutic protocol. HPD-NMES and LPD-NMES will receive an additional 30min-NMES protocol of high and low pulse duration, respectively. Pre and post intervention spasticity will be evaluated using Range of Motion (ROM) of the elbow joint through electronic goniometer, Modified Ashworth Scale (MAS) and surface electromyography (EMG). Furthermore, Modified Barthel Index (MBI) and 12-version of World Health Organization Disability Assessment Schedule (WHODAs) will be used for evaluating participants' quality of life. Statistical analysis will aim to highlight the effects of NMES both on the EMG-electrophysiological parameters and on clinical evaluation scales. Additionally, it will seek to determine which of the two NMES pulse durations produced more beneficial results in reducing spasticity levels.",[89,90],"Pyramidal Tract-related Spasticity","Upper Motor Neuron Lesion",[92,93,94,95,96],"spasticity","pyramidal tract","upper motor neuron lesion","electromyography","neuromuscular electrical stimulation","2026-03-19",{"date":99,"type":41},"2026-03-24",{"date":101,"type":41},"2026-01-06",{"date":103,"type":21},"2026-07-31",{"name":46,"class":47},1,{"id":107,"slug":108,"hasResults":11,"nctId":109,"briefTitle":110,"officialTitle":111,"acronym":4,"eligibilityCriteria":112,"healthyVolunteers":113,"sex":16,"minAge":55,"maxAge":114,"enrollmentInfo":115,"targetDuration":4,"studyType":22,"phases":117,"briefSummary":118,"conditions":119,"keywords":123,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":130,"lastUpdatePostDateStruct":131,"startDateStruct":133,"completionDateStruct":135,"leadSponsor":137,"locationsCount":105},"100627325","lumbar-stabilization-exercises-in-sedentary-adults-100627325","NCT07447167","Lumbar Stabilization Exercises in Sedentary Adults","The Effect of a Lumbar Stabilization Exercise Program on Quality of Life and Motor Control in Sedentary Adults","Inclusion Criteria:\n\n* Healthy adults with a sedentary lifestyle (no regular structured exercise in the past 2-3 months)\n\n  * Ability to participate in a moderate-intensity exercise program\n  * Ability to understand instructions and complete assessment questionnaires\n\nExclusion Criteria:\n\n* Regular participation in structured exercise programs within the previous 2-3 months\n\n  * Diagnosed lumbar disc herniation with neurological deficits\n  * History of spinal or lower limb surgery within the past year\n  * Acute musculoskeletal injury or exacerbation of low back pain within the past 4 weeks\n  * Neurological or neuromuscular disorders\n  * Active inflammatory rheumatic disease\n  * Cardiopulmonary contraindications to moderate-intensity exercise\n  * Pregnancy or postpartum period\n  * Use of medications significantly affecting balance or physical performance\n  * Inability to understand study instructions or comply with study procedures",true,"65 Years",{"count":116,"type":21},40,[24],"This pilot randomized controlled trial will examine the effects of a four-week lumbar spine stabilization exercise program on motor control, dynamic balance, and quality of life in healthy sedentary adults. Prolonged sedentary behavior has been associated with impaired neuromuscular function and increased risk of musculoskeletal disorders, even in asymptomatic individuals.\n\nForty sedentary adults will be randomly assigned to either an intervention group, which will follow a structured lumbar stabilization exercise program, or to a control group, which will receive ergonomic and stretching guidelines.\n\nOutcomes will be assessed before and after the intervention using the SF-12v2 quality of life questionnaire, the Functional Movement Screen (FMS) and the Y-Balance Test. Physical activity levels will be monitored using the IPAQ-SF. The study aims to determine whether lumbar stabilization exercises improve health-related quality of life, motor control and dynamic balance in sedentary adults.",[120,121,122],"Sedentary Behavior","Motor Control Impairment","Quality of Life",[124,125,126,127,128,129],"prevention","back pain","lumbar spine stabilization exercises","sedentary behavior","sedentary work","lack of physical activity","2026-03-02",{"date":132,"type":41},"2026-03-04",{"date":134,"type":21},"2026-02",{"date":136,"type":21},"2026-03",{"name":46,"class":47},{"id":139,"slug":140,"hasResults":11,"nctId":141,"briefTitle":142,"officialTitle":143,"acronym":144,"eligibilityCriteria":145,"healthyVolunteers":113,"sex":16,"minAge":55,"maxAge":146,"enrollmentInfo":147,"targetDuration":4,"studyType":22,"phases":149,"briefSummary":150,"conditions":151,"keywords":154,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":164,"lastUpdatePostDateStruct":165,"startDateStruct":167,"completionDateStruct":168,"leadSponsor":170,"locationsCount":4},"100621439","binaural-beats-stimulation-on-the-autonomic-nervous-system-ans-kinesiophobia-and-fitness-levels-in-professional-athletes-with-musculoskeletal-msk-injuries-100621439","NCT07370636","Binaural Beats Stimulation on the Autonomic Nervous System (ANS), Kinesiophobia and Fitness Levels in Professional Athletes With Musculoskeletal (MSK) Injuries","The Effect of Binaural Beats Stimulation on the Autonomic Nervous System, Considering Kinesiophobia of Reinjuries and Fitness Levels in Professional Athletes With Musculoskeletal Injuries","ANS MSK HRV","Inclusion Criteria:\n\n* Professional athletes in open-skill sports\n* Age 18-25 years old\n* Participation in national and\u002For international professional championships for ≥ 5 years\n* Athletes with previous lower limb musculoskeletal injuries within the past three months or longer\n* Athletes with previous lower limb musculoskeletal injuries who have been fully rehabilitated.\n* Injuries sustained during any training period or competitive event\n* Provoke injuries during any training period or competitive event\n* Athletes with Kinesiophobia who have presented Tampa of Scale Kinesiophobia (TSK) questionnaire scores ranging from 17 to 37\n* Athletes with Anxiety who have presented Sport Competition Anxiety Test (SCAT) questionnaire scores more than 17\n* Frequency of engaging in sports 3-5 times per week (training, competitions)\n* Duration of each training session not exceeding 90 minutes\n* Athletes with adequate proficiency in the English language\n\nExclusion Criteria:\n\n* Amateur and recreational athletes in open-skill activities\n* Athletes ≤ 17 and ≥ 26 years old\n* Athletes in close-skill sports\n* Athletes with current musculoskeletal injuries (\\\u003C 3 months)\n* Athletes with poor rehabilitation of sport injuries\n* Athletes with musculoskeletal injuries of upper limbs and trunk\n* Athletes with musculoskeletal injuries during off-season periods\n* Athletes with recent surgery\n* Athletes with a concussion that occurred during training or competition\n* Athletes with psychological and neurological problems\n* Athletes with hearing impairment\n* Athletes with inadequate proficiency in the English language","25 Years",{"count":148,"type":21},66,[24],"The purpose of the current study is to investigate the effectiveness of binaural beat stimulation on the autonomic nervous system (ANS), taking into account kinesiophobia related to reinjury and fitness levels in professional athletes with musculoskeletal injuries. The study hypothesis is that binaural beats will have beneficial effects by reducing ANS activity, primarily through modulation of parasympathetic nervous system (PNS) activity, as well as by reducing kinesiophobia related to reinjury and enhancing fitness levels in this population.\n\nResearchers will compare binaural beat stimulation to a placebo condition and to a condition without binaural beats in order to evaluate and compare the effects of those three conditions on psychological and physiological parameters in professional athletes with musculoskeletal injuries.\n\nParticipants will:\n\n* Receive receive music intervention either with binaural beat stimulation or placebo or music without binaural beats before their training sessions and competitions for a period of four weeks.\n* Maintain a diary to document each session of the music-based intervention.",[152,153],"Kinesiophobia (Fear of Movement)","Musculoskeletal Injuries",[155,156,157,158,159,160,161,162,163],"Binaural beats","kinesiophobia","Autonomic nervous system","sympathetic skin response","VO2max","Heart rate variability","grip strength test","pain","anxiety","2026-02-05",{"date":166,"type":41},"2026-02-10",{"date":134,"type":21},{"date":169,"type":21},"2027-06",{"name":46,"class":47},{"id":172,"slug":173,"hasResults":11,"nctId":174,"briefTitle":175,"officialTitle":176,"acronym":4,"eligibilityCriteria":177,"healthyVolunteers":11,"sex":16,"minAge":178,"maxAge":179,"enrollmentInfo":180,"targetDuration":4,"studyType":22,"phases":182,"briefSummary":183,"conditions":184,"keywords":186,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":191,"lastUpdatePostDateStruct":192,"startDateStruct":194,"completionDateStruct":196,"leadSponsor":198,"locationsCount":105},"100604196","effect-of-inspiratory-muscle-training-in-cognition-100604196","NCT07146373","Effect of Inspiratory Muscle Training in Cognition","The Effect of Strengthening Respiratory Muscles on Cognitive and Physical Functioning in Patients With Neurocognitive Disorders","Inclusion Criteria:\n\n* MMSE (Mini Mental State Examination) score ≤ 28 και ≥ 18\n* stable treatment related to medication\n\nExclusion Criteria:\n\n* MMSE score \\\u003C 18 και \\> 28\n* psychological disorder\n* any contraindication to physical training","60 Years","90 Years",{"count":181,"type":21},76,[24],"The goal of this clinical trial is to examine the effect of a respiratory muscle strengthening program on the cognitive and physical functioning of patients with neurocognitive disorders (Mild Cognitive Impairment) or those predisposed to them.\n\nThe main questions that aims to answer are:\n\n1. Is Inpsiratory Muscle Training (IMT) feasible in people with mild cognitive impairement?\n2. Could Inspiratory Muscle Training (IMT) improve congitive function in people with mild cognitive impairement?\n3. Could Inspiratory Musclre training improve physical function in this population?\n\nParticipants will be:\n\n1. \\\u003C 60 age or \\> 90 age\n2. MMSE (Mini Mental State Examination) score ≤ 28 and ≥ 18 and follow a high intensity IMT program along with a physical - cognitive program. or just the physical - cognitive program.",[185],"Mild Cognitive Impairment (MCI)",[187,188,189,190],"mild cognitive impairement","dementia","respiratory physiotherapy","inspiratory muscle training","2025-08-21",{"date":193,"type":41},"2025-08-28",{"date":195,"type":41},"2025-03-01",{"date":197,"type":21},"2028-05-30",{"name":46,"class":47},{"id":200,"slug":201,"hasResults":11,"nctId":202,"briefTitle":203,"officialTitle":204,"acronym":4,"eligibilityCriteria":205,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":206,"enrollmentInfo":207,"targetDuration":4,"studyType":22,"phases":209,"briefSummary":210,"conditions":211,"keywords":213,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":218,"lastUpdatePostDateStruct":219,"startDateStruct":221,"completionDateStruct":223,"leadSponsor":225,"locationsCount":105},"100603044","the-effect-of-inspiratory-muscle-training-in-people-with-gastroesophageal-reflux-disease-100603044","NCT07131397","The Effect of Inspiratory Muscle Training in People With Gastroesophageal Reflux Disease","The Effect of Inspiratory Muscle Training on Inspiratory Strength in People With Gastroesophageal Reflux Disease.","Inclusion Criteria: people diagnosed with GERD or had a score of more than 8 on the Gastroesophageal Reflux Disease Questionnaire\n\nExclusion Criteria: systemic connective tissue diseases, mental disorders, stomach or duodenal surgery, tuberculosis, pregnancy","70 Years",{"count":208,"type":21},30,[24],"The present Randomized Control Trial will be a single centric, two arm parallel equivalence randomized controlled. Participants will be assigned to either the Inspiratory MuscleTraining (IMT) group (investigation) or to Sham IMT group (control). The assessment times were three (3) before the start of the program (baseline-T1), immediately after the 3 months of the main exercise program (end of the main program-T2) and 6 months after (end of follow up-T3).\n\nThe measurements included: A. By measuring the Maximum Inspiratory Pressure (MIP) (Micro RPM) B. By measuring the Maximum Dynamic Inspiratory Pressure s-index (Powerbrethe K5)\n\nThe following instruments were included in the secondary outcome measures:\n\n* Recurrent Gastroesophageal Reflux Disease Questionnaire (measurement of symptom frequency-RDQ Questionaire).\n* Gastroesophageal Reflux Disease-Related Quality of Life Questionnaire (Quality of Life Measure-Reflux Qual short form questionnaire).",[212],"Gastro Esophageal Reflux",[214,215,216,217],"Inspiratory Muscle Training","Gastroesophageal Reflux Disease","Antireflux valve","Maximal Inspiratory Pressure","2025-08-15",{"date":220,"type":41},"2025-08-20",{"date":222,"type":41},"2025-01-08",{"date":224,"type":21},"2027-12-30",{"name":46,"class":47},{"id":227,"slug":228,"hasResults":11,"nctId":229,"briefTitle":230,"officialTitle":231,"acronym":4,"eligibilityCriteria":232,"healthyVolunteers":11,"sex":16,"minAge":55,"maxAge":4,"enrollmentInfo":233,"targetDuration":4,"studyType":22,"phases":235,"briefSummary":236,"conditions":237,"keywords":239,"overallStatus":37,"whyStopped":4,"lastUpdateSubmitDate":243,"lastUpdatePostDateStruct":244,"startDateStruct":246,"completionDateStruct":247,"leadSponsor":249,"locationsCount":4},"100600966","the-effect-of-inspiratory-muscle-training-on-breathing-pattern-and-functionality-in-patients-with-chronic-heart-failure-100600966","NCT07104357","The Effect of Inspiratory Muscle Training on Breathing Pattern and Functionality in Patients With Chronic Heart Failure.","The Effect of Inspiratory Muscle Training on Dysfunctional Breathing and Functional Ability in Patients With Chronic Heart Failure. A Study Protocol for a Randomized Controlled Trial","Inclusion Criteria:\n\n* adults aged ≥ 18 years\n* diagnosis of heart failure within the previous three to twelve months\n* current outpatients in a stable optimal medical regimen for at least 3 months\n* able to perform inspiratory muscle training\n* clinically stable, without hospital admission in the previous 3 months and without participation in any other training program in the previous 6 months\n\nExclusion Criteria\n\n* unstable angina\n* recent acute myocardial infarction\n* uncontrolled hypertension\n* valve disease\n* peripheral arterial disease\n* 6MWT assessment of less than 300 meters\n* previous pulmonary disease (forced vital capacity \\\u003C80% of predicted and\u002For forced expiratory volume in 1 s \\\u003C70% of predicted)\n* history of exercise-induced asthma\n* smokers",{"count":234,"type":21},18,[24],"The effect of inspiratory muscle training on breathing pattern and functionality in patients with chronic heart failure.",[238],"Breathing Pattern Disorder",[190,240,241,242],"dysfunctional breathing","functional ability","chronic heart failure","2025-07-28",{"date":245,"type":41},"2025-08-05",{"date":218,"type":21},{"date":248,"type":21},"2026-10-15",{"name":46,"class":47},{"id":251,"slug":252,"hasResults":11,"nctId":253,"briefTitle":254,"officialTitle":255,"acronym":256,"eligibilityCriteria":257,"healthyVolunteers":11,"sex":16,"minAge":258,"maxAge":259,"enrollmentInfo":260,"targetDuration":4,"studyType":22,"phases":262,"briefSummary":263,"conditions":264,"keywords":266,"overallStatus":67,"whyStopped":4,"lastUpdateSubmitDate":275,"lastUpdatePostDateStruct":276,"startDateStruct":278,"completionDateStruct":280,"leadSponsor":282,"locationsCount":76},"100566054","investigation-of-the-effect-of-music-on-the-stress-of-preterm-neonates-through-innovative-applications-sonata-100566054","NCT06650189","Investigation of the Effect of muSic on the Stress of Preterm neONates Through innovATive Applications (SONATA)","Investigation of the Effect of Music on the Stress of Preterm Neonates Through Innovative Applications","SONATA","Inclusion Criteria:\n\n* Born between 28 - 36+6 weeks of gestation\n* Absence of active infection including blood, urine, cerebrospinal fluid\n* Absence of congenital and genetic disorders and chromosomal abnormalities\n* Absence of nuclear jaundice\n* Absence of endocrine disorders\n* Absence of maternal use of illicit drugs prenatally\n* Non - sedated neonates\n* Positive bilateral transient evoked otoacoustic emissions\n* Stable clinical condition\n* Absence of brain injury\n\nExclusion Criteria:\n\n* Diagnosis of brain injury after the enrollment\n* Negative auditory brainstem response before discharge\n* Clinical deterioration","28 Weeks","37 Weeks",{"count":261,"type":21},70,[24],"The goal of this prospective randomized clinical trial is to investigate the effect of music intervention on the stress of live born preterm neonates requiring admission to a Neonatal Intensive Care Unit, through the measurements of salivary biomarkers (hormones and proteins).\n\nThe main question it aims to answer is:\n\nCan the daily music intervention reduce the stress levels created by the Neonatal Intensive Care Unit environment in preterm neonates?\n\nResearchers will compare preterm neonates who will not be exposed to music intervention to investigate potential discrepancies in salivary stress biomarkers.\n\nParticipants will be exposed to recorded music for 5 consecutive days.",[265],"Premature Neonates",[267,268,269,270,271,272,273,274],"preterm neonates","premature neonates","stress","salivary biomarkers","NICU","preterm infants","premature infants","music","2025-03-26",{"date":277,"type":41},"2025-04-01",{"date":279,"type":41},"2024-07-01",{"date":281,"type":21},"2026-07",{"name":46,"class":47},""]