[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-studies-list:{\"overallStatus\":[\"RECRUITING\",\"AVAILABLE\",\"NOT_YET_RECRUITING\"],\"leadSponsorName\":\"University of Wisconsin, Milwaukee\",\"orderBy\":\"LastUpdateSubmitDate:desc\",\"size\":25,\"offset\":0}":3,"health-study-condition:":102},{"pageToken":4,"total":5,"offset":6,"count":5,"results":7},null,3,0,[8,44,75],{"id":9,"slug":10,"hasResults":11,"nctId":12,"briefTitle":13,"officialTitle":13,"acronym":14,"eligibilityCriteria":15,"healthyVolunteers":16,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":19,"targetDuration":4,"studyType":22,"phases":4,"briefSummary":23,"conditions":24,"keywords":27,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":32,"lastUpdatePostDateStruct":33,"startDateStruct":36,"completionDateStruct":38,"leadSponsor":40,"locationsCount":43},"100495830","validating-a-new-machine-learned-accelerometer-algorithm-using-doubly-labeled-water-100495830",false,"NCT05736302","Validating a New Machine-Learned Accelerometer Algorithm Using Doubly Labeled Water","ValiDLW","Inclusion Criteria:\n\n* must be 18+ years of age\n* be able to ambulate on own, unassisted, on a regular basis\n* speak and read English\n* must have access to a working smart phone and a computer with internet access\n\nExclusion Criteria:\n\n* wheelchair reliant\n* assistive walking device reliant (cannot walk for at least 50 feet without an assistive device)\n* diagnosed uncontrolled hypertension (above 160\u002F100 mgHg)\n* diagnosed cognitive impairment or inability to follow study procedures such as Alzheimer's disease or dementia\n* cannot take metabolic altering medications\n* cannot be pregnant\n* cannot be breastfeeding\n* cannot use supplemental oxygen\n* cannot completed required study activities for any reason\n* cannot have a resting heart rate \\> 100 bpm or a resting blood pressure \\> 160 mgHg during Visit 1\n* cannot weigh more than 450 lbs",true,"ALL","18 Years",{"count":20,"type":21},125,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to validate previously developed physical function-clustered specific machine-learned accelerometer algorithms to estimate total daily energy expenditure (TDEE) in individuals with general movement and functional limitations.",[25,26],"Movement Disorders","Energy Metabolism",[28,29,30],"Doubly labeled water (DLW)","Total Daily Energy Expenditure (TDEE)","Accelerometry","RECRUITING","2026-04-27",{"date":34,"type":35},"2026-05-04","ACTUAL",{"date":37,"type":35},"2023-03-14",{"date":39,"type":21},"2026-12-31",{"name":41,"class":42},"University of Wisconsin, Milwaukee","OTHER",1,{"id":45,"slug":46,"hasResults":11,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":4,"eligibilityCriteria":50,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":4,"enrollmentInfo":51,"targetDuration":4,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":60,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":74},"100356116","emst-in-patients-undergoing-crt-for-hnca-100356116","NCT03916809","EMST in Patients Undergoing CRT for HNCA","Impact of Expiratory Muscle Strength Training (EMST) on Swallowing Function in Persons Undergoing Radiotherapy With or Without Chemotherapy (CRT) for Cancers of the Head and Neck (HNCA)","Inclusion Criteria:\n\n* New diagnosis of cancer in the oral cavity, oropharynx, hypopharynx, or larynx;\n* Planned treatment with primary radiotherapy with or without chemotherapy;\n* Age 18 or older and able to provide consent;\n* Ability to use the EMST150 device (hold in mouth and maintain lip seal)\n\nExclusion Criteria:\n\n* Primary surgery to the head and neck (neck dissection is permitted);\n* Unknown primary tumor;\n* Primary cancers of the nasopharynx, paranasal sinuses, salivary glands and skin.\n* Progressive neurologic condition affecting muscle strength (e.g. amyotrophic lateral sclerosis (ALS), Parkinson's disease)\n* Dysphagia not related to HNCA (e.g. unresolved swallowing difficulty post-stroke or post--traumatic brain injury (TBI))\n* Prior history of head and neck radiotherapy",{"count":52,"type":21},30,"INTERVENTIONAL",[55],"NA","This study is a randomized trial examining the impact of expiratory muscle strength training (EMST) on maintenance of safe and efficient oropharyngeal swallow function in persons with cancer of the head and neck (HNCA) undergoing treatment with radiation therapy or chemoradiotherapy (RT\u002FCRT).",[58,59],"Head and Neck Neoplasms","Deglutition Disorders",[61,62,63,64,65],"oropharyngeal cancer","laryngeal cancer","swallow","chemoradiation","expiratory muscle strength training","2024-12-03",{"date":68,"type":35},"2024-12-04",{"date":70,"type":35},"2017-07-12",{"date":72,"type":21},"2025-08-01",{"name":41,"class":42},2,{"id":76,"slug":77,"hasResults":11,"nctId":78,"briefTitle":79,"officialTitle":80,"acronym":81,"eligibilityCriteria":82,"healthyVolunteers":11,"sex":17,"minAge":18,"maxAge":83,"enrollmentInfo":84,"targetDuration":4,"studyType":53,"phases":86,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":31,"whyStopped":4,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":97,"completionDateStruct":99,"leadSponsor":101,"locationsCount":43},"100468234","neural-mechanisms-of-response-inhibition-training-for-ocrd-100468234","NCT05377125","Neural Mechanisms of Response Inhibition Training for OCRD","Neural Mechanisms of Response Inhibition Training for Obsessive-Compulsive Disorder and Related Conditions","OCRD","Inclusion Criteria:\n\n* age between 18 and 60\n* moderate level of OCRD symptoms (Yale-Brown Obsessive Compulsive Scale total ≥ 16, Massachusetts General Hospital-Hair pulling Scale total ≥ 12, or Skin Picking Scale-Revised total ≥ 7)\n* a primary diagnosis of OCRD (i.e., OCD, TTM, or SPD)\n* estimated IQ \\> 80\n* presence of a RI deficits (SSRT ≥ 215ms).\n\nExclusion Criteria:\n\n* Current substance use disorder\n* Severe ADHD\n* Lifetime diagnosis of psychotic disorder, bipolar disorder, or schizophrenia\n* Current psychotherapy\n* Change in psychotropic medication status within 8 weeks before the study or during the study\n* Use of stimulant medication\n* Active suicidal risk\n* Contraindications for MRI procedures","60 Years",{"count":85,"type":21},118,[55],"The impaired ability to suppress an inappropriate but pre-potent response (response inhibition; RI) characterizes several debilitating clinical problems, including obsessive-compulsive and related disorders (OCRD) such as obsessive-compulsive disorder, trichotillomania, and skin picking disorder. There is a critical need to develop an effective and durable treatment for OCRDs with demonstrable evidence for improving impaired RI. The purpose of our project is to examine the impact of a novel computerized intervention, response inhibition training (RIT), on neural indices of RI, and examine the mechanistic link between engagement of the neural RI targets and change in OCRD symptoms. To this end, this project will conduct a randomized clinical trial for individuals with OCD, trichotillomania, and\u002For skin picking disorders. Participants will be randomly assigned to 8 to 16 sessions of computerized RIT or a computerized placebo training. Various clinical, behavioral, and brain-imaging data will be acquired to evaluate the training effects at baseline, post-training, and 1-month follow-up periods.",[89,90,91],"Obsessive-Compulsive Disorder","Tricholemmoma","Skin-Picking",[93],"OCD; Trichotillomania; Excoriation; Response Inhibition","2024-07-17",{"date":96,"type":35},"2024-07-19",{"date":98,"type":35},"2022-12-22",{"date":100,"type":21},"2027-08",{"name":41,"class":42},""]